Max Gabutti, Kristine Heidemeyer, S Morteza Seyed Jafari, Simon Bossart, Robert E Hunger, Laurence Feldmeyer, Nikhil Yawalkar
This investigation demonstrates the use of dimethyl fumarate (DMF) for the treatment of disseminated granuloma annulare (GAD), a rare and chronic inflammatory skin disease. In this case, progressive GAD was treated with DMF, resulting in significant improvement of skin lesions within 5 weeks and complete healing within 7 months. Clinical response was associated with a reduction in inflammatory cells, including both T cell subsets (CD4+ > CD8+), CD183+ /CXCR3+ cells, Langerhans cells (CD1a+), myeloid DCs, M1- and M2-like macrophages and the activation marker HLA-DR in immunohistochemical analysis...
August 28, 2023: International Journal of Molecular Sciences