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Granuloma annulare

Pratik Mukesh Thacker, Kashinath Nayak, Flora Dorothy Lobo, Pavithra Govindasamy
Actinic granuloma is a self-limiting chronic disorder with elastolytic granulomas, mainly of the sun exposed skin and unknown pathogenesis. We report a case of a middle aged woman with multiple annular erythematous lesions. Histopathology revealed degenerated elastic fibres with histiocyte aggregates surrounded by multiple giant cells suggestive of elastolytic granulomas. She also had associated dyslipidemia and hypothyroidism. Actinic granuloma is relatively rare in the Indian population and needs to be differentiated from conditions like sarcoidosis and granuloma annulare...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
Miho Kabuto, Noriki Fujimoto, Toshihiro Tanaka
No abstract text is available yet for this article.
November 21, 2016: European Journal of Dermatology: EJD
Kevin Shen, Stacy V Smith, Andrew G Lee
No abstract text is available yet for this article.
October 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Shahira Ramadan, Dalia Hossam, Marwah A Saleh
BACKGROUND: Diagnosing cutaneous sarcoidosis and necrobiotic granulomas is challenging. OBJECTIVE: Assessing the value of dermoscopy in differentiating cutaneous sarcoidosis from necrobiotic granulomas and evaluating whether their dermoscopic features will be altered after treatment. METHODS: Nineteen cutaneous sarcoidosis and 11 necrobiotic granuloma patients (2 necrobiosis lipoidica, 4 granuloma annulare and 5 rheumatoid nodule) were included in this study...
July 2016: Dermatology Practical & Conceptual
Anh Khoa Pham, James G Dinulos, Timothy R Quinn
No abstract text is available yet for this article.
July 2016: JAAD Case Reports
Jesse James Johnston, Lynda Spelman
BACKGROUND: Granuloma annulare is a benign, inflammatory skin disorder with no distinct aetiology or widely accepted pathogenic process. CASE DESCRIPTION AND METHODS: We report a case of a 71-year old female with a 4-year history of an erythematous annulopapular lesion to the lateral aspect of her right forearm from a pressure pleat ridge in a high-density polyethylene plastic elbow orthosis to immobilise a prior radial head fracture. Morphological and histopathological assessment was consistent for granuloma annulare...
September 9, 2016: Prosthetics and Orthotics International
Menglong Ran, Yang Wang
A 64-year-old man presented with a 2-year history of asymptomatic, widespread, erythematous-to-violaceous papules that were distributed symmetrically on his trunk, arms, and legs (Panel A). The papules coalesced to form annular plaques, especially on the forearms and dorsal surfaces of the hands..
September 8, 2016: New England Journal of Medicine
Belén Lozano-Masdemont, Celia Horcajada-Reales, Laura Gómez-Recuero Muñoz, Verónica Parra-Blanco
No abstract text is available yet for this article.
August 26, 2016: Reumatología Clinica
Evan W Piette, Misha Rosenbach
Granuloma annulare (GA) represents a cutaneous reaction pattern of unknown cause with a variety of previously described potential disease associations and triggers. This review attempts to synthesize the available data regarding potential etiopathogenesis, reviews the available data on potential GA disease associations and work-up indicated for patients with GA, and discusses potential inciting triggers. In the final part, this article describes the available treatments options and supporting data, and provides a framework for approaching management of patients with GA...
September 2016: Journal of the American Academy of Dermatology
Evan W Piette, Misha Rosenbach
Granuloma annulare (GA) is a poorly understood condition characterized by a set of clinical morphologic variants with 2 predominant histopathologic patterns of inflammation. This review provides a comprehensive overview of the available information about the clinical variants and histopathologic features, current epidemiologic data, and potential genetic underpinnings of GA. Much of the current understanding of GA is based on retrospective studies, case series, and case reports; this review aims to synthesize the available information and present it clearly for practicing dermatologists...
September 2016: Journal of the American Academy of Dermatology
Emilia Javorsky, Alexis Perkins, Mark J Scharf
No abstract text is available yet for this article.
July 2016: Cutis; Cutaneous Medicine for the Practitioner
Liam Mercieca, Philip Carabot, Michael J Boffa
A 50-year-old man presented to the genitourinary medicine clinic with a 3-year history of skin-colored circular papules over the shaft and glans of the penis. There were multiple lesions that were initially small, around 0.3 cm in diameter, and gradually enlarged. Physical examination revealed five nodules over the glans and shaft of the penis, with the largest lesion measuring 3×1 cm over the lateral aspect of the shaft (Figure 1). There were no similar lesions elsewhere. There was no lymphadenopathy and the rest of the examination was unremarkable...
2016: Skinmed
Éric Toussirot, François Aubin
Paradoxical adverse events (PAEs) have been reported during biological treatment for chronic immune-mediated diseases. PAEs are defined as the occurrence during biological agent therapy of a pathological condition that usually responds to this class of drug. A wide range of PAEs have been reported including dermatological, intestinal and ophthalmic conditions, mainly with antitumour necrosis factor α (TNF-α) agents. True PAEs include psoriasis, Crohn's disease and hidradenitis suppurativa. Other PAEs may be qualified as borderline and include uveitis, scleritis, sarcoidosis and other granulomatous diseases (granuloma annulare, interstitial granulomatous dermatitis), vasculitis, vitiligo and alopecia areata...
2016: RMD Open
N Kanazawa, G Tchernev, A A Chokoeva, G K Maximov, U Wollina, T Lotti, J W Patterson, C Guarneri, C Tana, F Furukawa
We report the case of a 67-year-old female with a rare variant of interstitial granulomatous dermatitis showing multiple skin-colored papules. Clinically, numerous skin-colored or reddish papules were distributed on her back and posterior thighs with itchy scaly erythema on the upper back. After topical steroid application, skin-colored papules still remained after the disappearance of itchy scaly erythema. Histopathologically, perivascular and interstitial infiltration of lymphocytes and histiocytes with occasional multinucleated giant cells were observed in the superficial and mid reticular dermis, accompanied by mild mucin deposition...
April 2016: Journal of Biological Regulators and Homeostatic Agents
E Cozzani, D Basso, M A Cimmino, M Larosa, M Burlando, F Rongioletti, F Drago, A Parodi
Granuloma annulare (GA) is a chronic, benign, and usually self-limiting cutaneous inflammatory disease, typically characterized by small, localized, skin-coloured papules that are usually asymptomatic or mildly pruriginous. Its aetiopathogenesis is still unknown and treatments are rarely effective. Generally, 50-70% of localized GA cases are self-limiting and show spontaneous resolution after 1-2 years, whereas disseminated GA is less likely to disappear without treatment. Treatment of generalized GA is usually based on single case reports, and only a few studies involving large case series have been published...
August 2016: Clinical and Experimental Dermatology
Premanshu Bhushan, Sarvesh S Thatte, Avninder Singh
Sarcoidosis, a multisystem disease of obscure etiology, is characterized by the formation of noncaseating epithelioid cell granulomas in several organs or tissues. The diagnosis of sarcoidosis requires a compatible clinical picture, histologic demonstration of noncaseating granulomas, and exclusion of other diseases capable of producing similar histology or clinical features. The lung is the most commonly affected organ, but the skin is frequently involved. Sarcoidosis occurs worldwide and affects all ages and races with female predominance...
May 2016: Indian Dermatology Online Journal
Ruedee Phasukthaworn, Kumutnart Chanprapaph, Vasanop Vachiramon
Actinic granuloma is an uncommon granulomatous disease, characterized by annular erythematous plaque with central clearing predominately located on sun-damaged skin. The pathogenesis is not well understood, ultraviolet radiation is recognized as precipitating factor. We report a case of a 52-year-old woman who presented with asymptomatic annular erythematous plaques on the forehead and both cheeks persisting for 2 years. The clinical presentation and histopathologic findings support the diagnosis of actinic granuloma...
January 2016: Case Reports in Dermatology
Camilla Reggiani, Cesare Massone, Regina Fink-Puches, Carlo Cota, Lorenzo Cerroni
Interstitial mycosis fungoides (IMF) is a rare histopathologic variant of mycosis fungoides (MF) that may mimic other inflammatory dermatoses, mainly interstitial granuloma annulare, inflammatory morphea, and interstitial granulomatous dermatitis. Only small series and sporadic case reports of IMF have been described in the literature. We reviewed 27 specimens from 21 patients with IMF (M:F=11:10, median age 60) to better characterize clinical, histopathologic, and immunohistochemical features of this disease...
October 2016: American Journal of Surgical Pathology
Sasi Kiran Attili, Robert S Dawe, Sally H Ibbotson
BACKGROUND: Ultraviolet A1(UVA1) phototherapy is increasingly being used in the treatment of morphea, atopic dermatitis, lupus and some other recalcitrant dermatoses. We present a retrospective review of our experience with this modality. AIM: To evaluate the treatment response rates for various dermatoses and adverse effects of UVA1 phototherapy. METHODS: We reviewed phototherapy notes along with electronic and/or paper case records for all patients treated with UVA1 phototherapy from October 1996 to December 2008...
May 23, 2016: Indian Journal of Dermatology, Venereology and Leprology
Eriko Maehara, Naoko Wada, Hiroko Takamatsu, Kayo Harada, Shuhei Imayama, Seiichi Okamura, Kazunori Urabe
No abstract text is available yet for this article.
August 1, 2016: European Journal of Dermatology: EJD
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