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https://www.readbyqxmd.com/read/28922729/lithium-induced-oxidative-damage-and-inflammation-in-the-rat-s-heart-protective-effect-of-grape-seed-and-skin-extract
#1
Ali Mezni, Hanène Aoua, Olfa Khazri, Ferid Limam, Ezzeddine Aouani
Lithium (Li) is a relevant mood stabilizer metal for the treatment of bipolar disorder (BD), as it protects from both depression and mania and reduces the risk of suicide. However, Lihas some clinical concerns as a narrow therapeutic index requiring routine monitoring of the serum level. The present study was designed to analyze the cardio-toxic side effect of Li and the ability of grape seed and skin extract (GSSE) to protect the heart against such toxicity. After 30days of exposure to Li (0, 2, 5 and 100mg/kg bw) and prevention with GSSE (4000mg/kg bw), rats were killed by decapitation and their heart processed for Li-induced oxidative stress...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28918452/pro-oxidant-status-and-nrf2-levels-in-psoriasis-vulgaris-skin-tissues-and-dimethyl-fumarate-treated-hacat-cells
#2
Yoon Jin Lee, Jin Ho Bae, Sang-Gue Kang, Sung Woo Cho, Dong-Il Chun, Seung Min Nam, Chul Han Kim, Hae Seon Nam, Seon Hwa Lee, Sang Han Lee, Moon Kyun Cho
Reactive oxygen species (ROS) contribute to pathogenesis of many inflammatory skin diseases, including psoriasis. The aim of this study is to compare antioxidant protein expression in psoriasis vulgaris (PV) skin tissues with that in normal skin tissues in vivo and to evaluate the effects of dimethyl fumarate (DMF), used for the treatment of psoriasis, on ROS generation and apoptosis in a human keratinocyte cell line HaCaT. Compared with normal skin tissues, PV skin tissues showed increased protein oxidation as well as down-regulation of Nrf2 and its regulatory proteins such as HO-1 and AKR1C3...
September 16, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28912844/triptolide-inhibits-cd4-memory-t-cell-mediated-acute-rejection-and-prolongs-cardiac-allograft-survival-in-mice
#3
Shuiwei Qiu, Dingliang Lv
There have been numerous investigations into the immunosuppressive effects of triptolide; however, its inhibitory effects on memory T cells remain to be elucidated. Using a cluster of differentiation (CD)4(+) memory T-cell transfer model, the aim of the present study was to determine the inhibitory effects of triptolide on CD4(+) memory T cell-mediated acute rejection and to determine the potential underlying mechanisms. At 4 weeks after skin transplantation, mouse cervical heart transplantation was performed following the transfer of CD4(+) memory T cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912452/endogenous-%C3%AF-3-fatty-acid-production-by-fat-1-transgene-and-topically-applied-docosahexaenoic-acid-protect-against-uvb-induced-mouse-skin-carcinogenesis
#4
Hye-Won Yum, Jin Park, Hyun-Jung Park, Jun Wan Shin, Yong-Yeon Cho, Su-Jung Kim, Jing X Kang, Young-Joon Surh
The present study was intended to explore the effects of endogenously produced ω-3 polyunsaturated fatty acids (PUFAs) on ultraviolet B (UVB)-induced skin inflammation and photocarcinogenesis using hairless fat-1 transgenic mice harboring ω-3 desaturase gene capable of converting ω-6 to ω-3 PUFAs. Upon exposure to UVB irradiation, fat-1 transgenic mice exhibited a significantly reduced epidermal hyperplasia, oxidative skin damage, and photocarcinogenesis as compared to wild type mice. The transcription factor, Nrf2 is a master regulator of anti-inflammatory and antioxidant gene expression...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894510/antioxidant-and-anti-inflammatory-effects-of-shungite-against-ultraviolet-b-irradiation-induced-skin-damage-in-hairless-mice
#5
Ma Easter Joy Sajo, Cheol-Su Kim, Soo-Ki Kim, Kwang Yong Shim, Tae-Young Kang, Kyu-Jae Lee
As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand. While shungite is regarded as a natural source of fullerene, it remains poorly documented. Here, we explored the in vivo effects of shungite against ultraviolet B- (UVB-) induced skin damage by investigating the physiological skin parameters, immune-redox profiling, and oxidative stress molecular signaling. Toward this, mice were UVB-irradiated with 0.75 mW/cm(2) for two consecutive days...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28884409/chronic-exposure-to-rapamycin-and-episodic-serum-starvation-modulate-ageing-of-human-fibroblasts-in-vitro
#6
Lakshman Sodagam, Anna Lewinska, Maciej Wnuk, Suresh I S Rattan
Mild stress-induced activation of stress response (SR) pathways, such as autophagy, heat shock response, oxidative SR, DNA damage response, and inflammatory response, can be potentially health beneficial. Using the model system of cellular ageing and replicative senescence in vitro, we have studied the ageing modulatory effects of the two conditions, rapamycin and serum starvation. Chronic exposure to 0.1, 1 and 10 nM rapamycin positively modulated the survival, growth, morphology, telomere length, DNA methylation levels, 8-oxo-dG level in DNA, N(6)-methyl-adenosine level in RNA, and ethanol stress tolerance of serially passaged normal human skin fibroblasts...
September 7, 2017: Biogerontology
https://www.readbyqxmd.com/read/28869804/erosive-pustular-dermatosis-of-the-scalp-and-kindler-syndrome-a-new-association
#7
L Atzori, M Lai, A Lappi, M A Brundu, F Rongioletti
Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disease that predominantly affects elderly people, with a chronic course and long-term management.(1) Sterile pustules, superficial erosions and crusted lesions on atrophic skin, resulting in cicatricial alopecia, characterize the typical clinical presentation. (1-3) Triggering factors include several drugs, actinic damage, local trauma, surgery, and physical or chemical procedures for actinic keratosis.(4-6) To the best of our knowledge, no previous association with Kindler syndrome was found in the literature...
September 4, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28868137/case-report-nicolau-syndrome-due-to-etofenamate-injection
#8
Emin Ozlu, Aysegul Baykan, Ragıp Ertas, Yılmaz Ulas, Kemal Ozyurt, Atıl Avcı, Halit Baykan
Nicolau syndrome, also known as embolia cutis medicomentosa, is a rare complication characterized by tissue necrosis that occurs after injection of drugs. The exact pathogenesis is uncertain, but there are several hypotheses, including direct damage to the end artery and cytotoxic effects of the drug. Severe pain in the immediate postinjection period and purplish discoloration of the skin with reticulate pigmentary pattern is characteristic of this syndrome. Diagnosis is mainly clinical and there is no standard treatment for the disease...
2017: F1000Research
https://www.readbyqxmd.com/read/28865317/photoprotection-against-uv-induced-damage-by-skin-derived-precursors-in-hairless-mice
#9
Dehai Xian, Xiaoqing Gao, Xia Xiong, Jixiang Xu, Lingyu Yang, Lun Pan, Jianqiao Zhong
BACKGROUND: Skin photodamage is associated with UV-induced overproduction of reactive oxygen species (ROS) and the inactivation of NF-E2-related factor 2 (Nrf2). Skin-derived precursor cells (SKPs), a population of dermal stem cells, are considered to be involved in wound repair and skin regeneration through the activation of Nrf2. However, no reports concentrate on the treatment of skin photodamage with SKPs. OBJECTIVE: To investigate the photoprotective role of SKPs against UV-induced damage in mice...
August 23, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28859262/increased-levels-of-inflammatory-proteins-typify-the-earliest-phase-of-systemic-sclerosis
#10
Marta Cossu, Lenny van Bon, Carlo Preti, Marzia Rossato, Lorenzo Beretta, Timothy R D J Radstake
OBJECTIVE: Definite systemic sclerosis patients lacking fibrotic features stratify in an intermediate severity stage between preclinical/early (EaSSc) and fibrotic subsets (limited and diffuse cutaneous [lcSSc, dcSSc]). We aimed to molecularly characterize non-fibrotic SSc and EaSSc on the basis of a broad panel of serum markers of inflammation and tissue damage to increase the knowledge of pathophysiologic mechanisms underlying SSc progression before development of fibrosis. METHODS: An 88-plex immunoassay was performed in sera from a discovery cohort composed of 21 EaSSc (LeRoy and Medsger criteria), 15 non-fibrotic SSc (2013 ACR/EULAR criteria without skin or lung fibrosis) and 11 HC...
August 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28858391/pterocarpus-santalinus-l-regulated-ultraviolet-b-irradiation-induced-procollagen-reduction-and-matrix-metalloproteinases-expression-through-activation-of-tgf-%C3%AE-smad-and-inhibition-of-the-mapk-ap-1-pathway-in-normal-human-dermal-fibroblasts
#11
Wei Gao, Pei Lin, Eunson Hwang, Yushuai Wang, Zhengfei Yan, Hien T T Ngo, Tae-Hoo Yi
Ultraviolet light-induced reactive oxygen species (ROS) damage human skin and prematurely cause aging. A growing body of research is focusing on considering plants and plant-derived compounds as anti-photoaging therapeutic material. Pterocarpus santalinus L., as an Indian traditional medicine, possesses antidiabetic, anti-inflammatory and antioxidative effects. Here, we studied the anti-photoaging effects of ethanolic extract of P. santalinus L. heartwood (EPS) on ultraviolet radiation B (UVB)-irradiated normal human dermal fibroblasts (NHDFs)...
August 31, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28852851/il-36-cytokines-are-increased-in-acne-and-hidradenitis-suppurativa
#12
Roberta Di Caprio, Anna Balato, Giuseppina Caiazzo, Serena Lembo, Annunziata Raimondo, Gabriella Fabbrocini, Giuseppe Monfrecola
Interleukin (IL)-36 cytokines are new members of the IL-1 family, which include pro-inflammatory factors, IL-36α, IL-36β and IL-36γ, and a natural receptor antagonist IL-36Ra. Over recent years, much has been learned on their important functions in the regulation of immune response and, especially, on their role in many inflammatory skin diseases. However, to date, no data have been reported on their possible involvement in acne and hidradenitis suppurativa (HS). Here, we have shown that IL-36α, IL-36β, and IL-36γ are increased in lesional skin of acne and HS, highlighting their possible pathogenetic contribution to these two skin conditions...
August 29, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28840618/the-beneficial-effect-of-anthocyanidin-rich-vitis-vinifera-l-grape-skin-extract-on-metabolic-changes-induced-by-high-fat-diet-in-mice-involves-antiinflammatory-and-antioxidant-actions
#13
Gisele França da Costa, Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28834114/galangin-suppresses-h2-o2-induced-aging-in-human-dermal-fibroblasts
#14
Su-Ying Wen, Jia-Yi Chen, Yueh-Shan Weng, Ritu Aneja, Chih-Jung Chen, Chih-Yang Huang, Wei-Wen Kuo
Human skin aging is a progressive process that includes intrinsic aging and extrinsic photodamage, both of which can cause an accumulation of reactive oxygen species (ROS), resulting in dermal fibrosis dysfunction and wrinkle formation. Galangin is a flavonoid that exhibits anti-inflammatory and antioxidative potential. Previous studies have reported that galangin has antioxidative activity against ROS-mediated stress. The aim of the present study is to determine the antiaging effects of galangin on dermal fibroblasts exposed to H2 O2 ...
August 18, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28834104/myricetin-protects-keratinocyte-damage-induced-by-uv-through-i%C3%AE%C2%BAb-nf%C3%AE%C2%BAb-signaling-pathway
#15
Jing Xie, Yanyan Zheng
OBJECTIVE: The aim of this study was to evaluate the potential molecular mechanism of myricetin that protecting cells from photodamage. METHODS: Myricetin had broadly chemopreventive effects and anti-inflammatory properties. The effect of myricetin was assessed on HaCaT cells. Cell viability assay was carried out. Reactive oxygen species (ROS) level was measured. The expression of pro-inflammatory factor COX2 was determined by real-time PCR and Western blot. The protein levels of p-IκBa and IκBa were determined by Western blot...
August 17, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28831227/effects-of-herbal-ointment-containing-the-leaf-extracts-of-madeira-vine-anredera-cordifolia-ten-steenis-for-burn-wound-healing-process-on-albino-rats
#16
Wiwik Misaco Yuniarti, Bambang Sektiari Lukiswanto
AIM: Skin burn is a health problem that requires fast and accurate treatment. If not well-treated, the burn will cause various damaging conditions for the patient. The leaf extract of Madeira vine (Anredera cordifolia (Ten.) Steenis), or popularly known as Binahong in Indonesia, has been used to treat various diseases. The purpose of this research is to determine the effects of leaf extracts of Madeira vine (A. cordifolia (Ten.) Steenis) on skin burn healing process in rats as an animal model...
July 2017: Veterinary World
https://www.readbyqxmd.com/read/28820401/intraepidermal-nerve-fiber-density-in-vulvar-lichen-sclerosus-and-normal-vulvar-tissues
#17
K Milian-Ciesielska, L Chmura, G Dyduch, C Jagers, E Radwanska, D Adamek
Lichen sclerosus (LS) is a chronic and inflammatory disease causing sensory symptoms such as itch and pain and affecting most frequently genital skin of women. Intraepidermal nerve fiber density (IENFD) was examined immunohistologically in 20 vulvar skin biopsies of patients affected by LS and in 20 control vulvar skin biopsies, in order to determine if these sensory sensations originate in changes in the epidermal innervation. Obtained results show fewer protein gene product 9.5 (PGP 9.5) positive intraepidermal nerve fibers (IENF) in LS tissues compared to controls (P = 0...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28813557/facial-erosive-pustular-dermatosis-after-cosmetic-resurfacing
#18
Julie E Mervak, Stephanie D Gan, Emily H Smith, Frank Wang
Importance: Erosive pustular dermatosis (EPD) is a rare condition that typically affects actinically damaged skin of the scalp. Characterized by sterile pustules, erosions, and crusts, EPD is difficult to treat and heals slowly. The exact cause of EPD is unknown, although trauma is an inciting factor. Objective: To describe 3 women who presented with prolonged facial erosions after cosmetic resurfacing procedures, specifically fully ablative carbon dioxide laser or medium-depth chemical peel...
August 16, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28806055/selective-release-system-for-antioxidative-and-anti-inflammatory-activities-using-h2o2-responsive-therapeutic-nanoparticles
#19
A Young Kim, Ji Hoon Ha, Soo Nam Park
We developed nanoparticles that were degraded by H2O2, a reactive oxygen species (ROS), to study a drug delivery system that targets damaged skin cells with oxidative stress and inflammation. In this study, tyrosol-incorporated copolyoxalate (TPOX) was synthesized by using 1,4-cyclohexanedimethanol, 4-(2-hydroxyethyl)phenol (tyrosol) and oxalyl chloride (Mw ~8835 Da). In vitro drug release behavior was assessed by loading nile red, a lipophilic fluorescent material such as quercetin, into the TPOX nanoparticles...
August 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28797111/angiogenic-t-cell-expansion-correlates-with-severity-of-peripheral-vascular-damage-in-systemic-sclerosis
#20
Mirko Manetti, Sara Pratesi, Eloisa Romano, Silvia Bellando-Randone, Irene Rosa, Serena Guiducci, Bianca Saveria Fioretto, Lidia Ibba-Manneschi, Enrico Maggi, Marco Matucci-Cerinic
The mechanisms underlying endothelial cell injury and defective vascular repair in systemic sclerosis (SSc) remain unclear. Since the recently discovered angiogenic T cells (Tang) may have an important role in the repair of damaged endothelium, this study aimed to analyze the Tang population in relation to disease-related peripheral vascular features in SSc patients. Tang (CD3+CD31+CXCR4+) were quantified by flow cytometry in peripheral blood samples from 39 SSc patients and 18 healthy controls (HC). Circulating levels of the CXCR4 ligand stromal cell-derived factor (SDF)-1α and proangiogenic factors were assessed in paired serum samples by immunoassay...
2017: PloS One
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