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Allergic contact dermatitis

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https://www.readbyqxmd.com/read/28338543/clinical-study-of-124-patients-having-perianal-dermatitis
#1
Alfredo-Daniel Agulló-Pérez, Marcos Hervella-Garcés, Saioa Oscoz-Jaime, Maialen Azcona-Rodríguez, Mónica Larrea-García, Juan-Ignacio Yanguas-Bayona
BACKGROUND: Perianal complaints are often consulted in dermatology clinics, and in many cases, a conclusive diagnosis is not easily made. OBJECTIVE: The aim of this study was to study and identify the epidemiological, clinical, and contact allergy features of patients with perianal dermatitis who attended at a contact dermatitis unit in a tertiary hospital in Spain. METHODS: Adult patients with long-lasting (>4 weeks) perianal dermatitis were recruited during the past 10 years for investigation and follow-up...
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28338542/multicenter-patch-testing-with-methylisothiazolinone-and-methylchloroisothiazolinone-methylisothiazolinone-within-the-international-contact-dermatitis-research-group
#2
Marléne Isaksson, Iris Ale, Klaus E Andersen, Peter Elsner, Chee-Leok Goh, An Goossens, Hemangi Jerajani, Kayoko Matsunaga, John McFadden, Magnus Bruze
BACKGROUND: The preservatives methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI are well-known contact sensitizers. Recently, an increase in the contact allergy frequency for MI 0.2% aqueous (aq) has been seen in many European countries paralleled with an increase in MCI/MI allergy. Many of the MI-allergic patients do not react to MCI/MI 0.01% or 0.02% because the concentration of MI in these preparations is too low (25 and 50 ppm, respectively) to elicit a positive patch test reaction...
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28338541/intralesional-treatment-with-5-fluorouracil-and-steroid-improves-allergic-contact-dermatitis-without-causing-skin-atrophy-and-rebound-lesions
#3
Xiangming Chen, Guojiang Wang, Qingwen Zeng, Haiqing Zhang, Yang Hu, Aihua Yu, Ting Li
No abstract text is available yet for this article.
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28338540/occupational-contact-dermatitis-in-north-american-print-machine-operators-referred-for-patch-testing-retrospective-analysis-of-cross-sectional-data-from-the-north-american-contact-dermatitis-group-1998-to-2014
#4
Erin M Warshaw, Solveig L Hagen, Donald V Belsito, Joel G DeKoven, Howard I Maibach, C G Toby Mathias, Kathryn A Zug, Denis Sasseville, Matthew J Zirwas, Joseph F Fowler, Anthony F Fransway, Vincent A DeLeo, James G Marks, Melanie D Pratt, James S Taylor
BACKGROUND: Little is known about the epidemiology of contact dermatitis (CD) in print machine operators (PMOs). OBJECTIVE: The aims of this study were to estimate the prevalence of CD and characterize clinically relevant and occupationally related allergens among PMOs undergoing patch testing. METHODS: This was a retrospective cross-sectional analysis of the North American Contact Dermatitis Group data from 1998 to 2014. RESULTS: Of 39,332 patch-tested patients, 132 (0...
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28338538/allergenic-ingredients-in-facial-wet-wipes
#5
Kelly A Aschenbeck, Erin M Warshaw
BACKGROUND: Allergic contact dermatitis commonly occurs on the face. Facial cleansing wipes may be an underrecognized source of allergens. OBJECTIVE: The aim of this study was to determine the frequency of potentially allergenic ingredients in facial wet wipes. METHODS: Ingredient lists from name brand and generic facial wipes from 4 large retailers were analyzed. RESULTS: In the 178 facial wipes examined, a total of 485 ingredients were identified (average, 16...
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28338537/allergenic-ingredients-in-personal-hygiene-wet-wipes
#6
Kelly A Aschenbeck, Erin M Warshaw
BACKGROUND: Wet wipes are a significant allergen source for anogenital allergic contact dermatitis. OBJECTIVE: The aim of the study was to calculate the frequency of potentially allergenic ingredients in personal hygiene wet wipes. METHODS: Ingredient lists from brand name and generic personal hygiene wet wipes from 4 large retailers were compiled. RESULTS: In the 54 personal hygiene wet wipes evaluated, a total of 132 ingredients were identified (average of 11...
March 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28329482/prevention-of-poison-ivy-dermatitis-with-oral-homeopathic-rhus-toxicodendron
#7
Robert Joseph Signore
Acute allergic contact dermatitis to poison ivy is acommon and miserable dermatosis which affectsmillions of Americans each year. Preventativemeasures, such as avoidance, protective clothing,barrier creams, soaps, and solvents often fail despiteour patients' best attempts. Severe allergic reactionsto poison ivy are a significant source of decreasedemployee productivity owing to inability to work anda major health care expenditure. Patients may haveto leave their jobs and discontinue favorite outdoorrecreational activities as a result of severe urushiolsensitivity...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328819/prevalence-and-risk-factors-of-contact-dermatitis-among-clothing-manufacturing-employees-in-beijing-a-cross-sectional-study
#8
Yu-Xin Chen, Hai-Yan Cheng, Lin-Feng Li
Little is known about the epidemiology of contact dermatitis (CD) in the Chinese clothing industry. This study aimed to investigate the prevalence and some risk factors of contact dermatitis among clothing manufacturing employees in Beijing.This cross-sectional study was conducted by interview using self-administered questionnaires and skin examination between May and August in 2016. Five-hundred twenty-nine employees who had worked at sewing, ironing, and as managers at 12 clothing manufacturing factories were studied...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28326907/skin-sensitizers-in-cosmetics-and-beyond-potential-multiple-mechanisms-of-action-and-importance-of-t-cell-assays-for-in-vitro-screening
#9
Stanislav Vukmanović, Nakissa Sadrieh
Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity (DTH) reaction induced by repeated contact with sensitizers. The ability of a chemical to act as a sensitizer has most frequently been tested in animals. As the use of animals for these purposes is gradually and globally being phased out, there is a need for reliable in vitro surrogate assays. Currently proposed in vitro assays are designed to test four key events of the adverse outcome pathway (AOP) involving covalent modification of self-proteins by sensitizers (haptenation) and presentation of new antigens (hapten/carrier complexes) to the immune system...
March 22, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28320580/roles-of-alternatively-activated-m2-macrophages-in-allergic-contact-dermatitis
#10
REVIEW
Kotaro Suzuki, Kazuyuki Meguro, Daiki Nakagomi, Hiroshi Nakajima
Alternatively activated macrophages (M2 macrophages) play key roles in the suppression of Th1 cell responses and the orchestration of tissue repair. However, recent studies have shown that M2 macrophages have potentials to produce high levels of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α, suggesting that M2 macrophages may exacerbate inflammation in some settings. In this regard, we have recently shown that large numbers of M2 macrophages accumulate in the sites of hapten-induced contact hypersensitivity (CHS), an animal model of allergic contact dermatitis, and that M2 macrophages exacerbate hapten-induced CHS by producing matrix metalloproteinase 12 (MMP12)...
March 17, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28318051/atopic-dermatitis-in-israeli-adolescents-from-1998-to-2013-trends-in-time-and-association-with-migraine
#11
Rony Shreberk-Hassidim, Ayal Hassidim, Yoav Gronovich, Adam Dalal, Vered Molho-Pessach, Abraham Zlotogorski
BACKGROUND: Recent data have shown an increasing occurrence of atopic dermatitis (AD) in children and adolescents, as well as in adults. Most of the epidemiologic research on AD is limited to pediatric and youth populations and is based on self-reported questionnaires. METHODS: A nationwide, population-based, cross-sectional retrospective study of adolescents with AD was performed to estimate its prevalence, trends, and association with demographic factors and comorbidities...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28317196/severe-bullous-allergic-contact-dermatitis-caused-by-diethylthiourea-20-years-after-sensitization-to-neoprene
#12
Anne Bregnhøj, Mette Sommerlund
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28317191/allergic-contact-dermatitis-caused-by-motorcycle-heated-grips
#13
Nicola Milanesi, Massimo Gola, Stefano Francalanci
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28317187/occupational-allergic-contact-dermatitis-caused-by-1-propanol-in-a-hand-disinfectant
#14
Hilde M Bosker, Klaziena Politiek, Merel C Urgert, Peter A Flach, Pieter-Jan Coenraads, Marie Louise Schuttelaar
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28317186/intolerance-to-cosmetics-as-key-to-the-diagnosis-in-a-patient-with-allergic-contact-dermatitis-caused-by-propylene-glycol-contained-in-a-topical-medication
#15
Noelia Hernández, Zaida Hernández, Federica Liuti, Leopoldo Borrego
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28300444/methylisothiazolinone-contact-allergy-prevalence-in-western-canada
#16
Jessica E Wilford, Gillian C de Gannes
BACKGROUND: Contact allergy to methylisothiazolinone (MI) or to the combination of methylchloroisothiazolinone and MI (MCI/MI) is an important and increasing cause of allergic contact dermatitis, with prevalence rates higher than 10% in some centers. OBJECTIVES: The objective of this retrospective chart review is to provide a western Canadian perspective on whether the positive patch testing rate to MCI/MI or MI increased during the testing period of 2008 to 2015 and whether the addition of MI at 2000 ppm resulted in increased detection...
January 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28300283/immunology-and-genetics-of-tumour-necrosis-factor-in-allergic-contact-dermatitis
#17
REVIEW
Daan Dittmar, Marie Louise Schuttelaar
During the sensitization phase of allergic contact dermatitis, the proinflammatory cytokine tumour necrosis factor (TNF) plays an important role by promoting epidermal Langerhans cell migration to draining lymph nodes. It also plays a role during the elicitation phase. The TNF gene (TNF) is located within the major histocompatibility complex region. Many single-nucleotide variants exist in the promoter region of TNF, and these may either increase or decrease mRNA transcription and therefore lead to higher or lower levels of TNF...
March 16, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28296664/histomorphology-and-immunophenotype-of-eczematous-skin-lesions-revisited-skin-biopsies-are-not-reliable-in-differentiating-allergic-contact-dermatitis-irritant-contact-dermatitis-and-atopic-dermatitis
#18
Verena G Frings, Almut Böer-Auer, Kristine Breuer
Lesions of allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), and atopic dermatitis (AD) share similar clinical features and thus, their diagnosis can be challenging. The aim of this study was to reassess histopathology and immunophenotyping properties to distinguish between ACD, ICD, and AD. Charts of patients with eczema, who had undergone complete routine diagnostic workup (skin biopsies, patch tests, skin prick tests, and respectively or serum IgE levels), were reviewed. Thirty-five skin biopsy specimens of 28 patients (mean age 64 ± 15 years; ♀ = 13 ♂ = 15) with clear diagnosis of ACD (n = 15), ICD (n = 6), or AD (n = 14) were analyzed...
March 10, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28295421/effect-of-allergens-and-irritants-on-levels-of-natural-moisturizing-factor-and-corneocyte-morphology
#19
Sjors A Koppes, Suzana Ljubojević Hadžavdić, Ivone Jakasa, Nika Franceschi, Christoph Riethmüller, Ružica Jurakić Tončic, Branka Marinovic, Nidhin Raj, Anthony V Rawlings, Rainer Voegeli, Majella E Lane, Marek Haftek, Monique H W Frings-Dresen, Thomas Rustemeyer, Sanja Kezic
BACKGROUND: The irritant sodium lauryl sulfate (SLS) is known to cause a decrease in the stratum corneum level of natural moisturizing factor (NMF), which in itself is associated with changes in corneocyte surface topography. OBJECTIVE: To explore this phenomenon in allergic contact dermatitis. METHODS: Patch testing was performed on patients with previously positive patch test reactions to potassium dichromate (Cr), nickel sulfate (Ni), methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI), or p-phenylenediamine...
March 14, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28292894/receptor-mincle-promotes-skin-allergies-and-is-capable-of-recognizing-cholesterol-sulfate
#20
Alexey V Kostarnoy, Petya G Gancheva, Bernd Lepenies, Amir I Tukhvatulin, Alina S Dzharullaeva, Nikita B Polyakov, Daniil A Grumov, Daria A Egorova, Andrey Y Kulibin, Maxim A Bobrov, Ekaterina A Malolina, Pavel A Zykin, Andrey I Soloviev, Evgeniy Riabenko, Diana V Maltseva, Dmitry A Sakharov, Alexander G Tonevitsky, Lyudmila V Verkhovskaya, Denis Y Logunov, Boris S Naroditsky, Alexander L Gintsburg
Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation; however, the underlying molecular mechanisms are not yet completely understood. Here, we show that cholesterol sulfate, a molecule present in relatively high concentrations in the epithelial layer of barrier tissues, is selectively recognized by Mincle (Clec4e), a C-type lectin receptor of the innate immune system that is strongly up-regulated in response to skin damage...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
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