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Allergic contact dermatitis

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https://www.readbyqxmd.com/read/28638049/immunomodulatory-effects-of-nanoparticles-on-skin-allergy
#1
Samreen Jatana, Brian C Palmer, Sarah J Phelan, Lisa A DeLouise
In recent years there has been considerable effort to understand the interaction of nanomaterials with the skin. In this study we use an in vivo mouse model of allergic contact dermatitis to investigate how nanoparticles (NPs) may alter allergic responses in skin. We investigate a variety of NPs that vary in size, charge and composition. Results show that small (<200 nm) negative and neutral charged NPs exhibit an immunosuppressive effect but that positively charged NPs do not. Confocal imaging suggests positively charged NPs may penetrate skin to a lesser extent and thereby are less able interact with and alter the local immune responses...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634033/nickel-sulfate-promotes-il-17a-producing-cd4-t-cells-by-an-il-23-dependent-mechanism-regulated-by-tlr4-and-jak-stat-pathways
#2
Rami Bechara, Diane Antonios, Hayat Azouri, Marc Pallardy
Allergic contact dermatitis, caused by nickel, is a delayed-type hypersensitivity reaction and 14.5% of the general population may be affected in Europe. Among a wide range of cytokines, the IL-12 family has unique structural and immunological characteristics. While IL-12p70 promotes T helper (Th) 1 cells polarization, IL-23 promotes Th17 cells development and both have been isolated from nickel-allergic patients. In this work, we were interested in understanding the mechanism behind nickel-induced Th17 cells development...
June 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28632331/the-validity-of-register-data-to-identify-children-with-atopic-dermatitis-asthma-or-allergic-rhinoconjunctivitis
#3
Lone Graff Stensballe, Lotte Klansø, Andreas Jensen, Ann Haerskjold, Simon Francis Thomsen, Jacob Simonsen
BACKGROUND: The incidence of atopic dermatitis, wheezing, asthma and allergic rhinoconjunctivitis have been increasing. Register-based studies are essential for research in subpopulations with specific diseases, and facilitate epidemiological studies to identify causes and evaluate interventions. Algorithms have been developed to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis using register information on disease-specific dispensed prescribed medication and hospital contacts, but the validity of the algorithms has not been evaluated...
June 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28632093/allergic-contact-dermatitis-from-ophthalmics
#4
Yue Zheng, Paru R Chaudhari, Howard I Maibach
In this article we summarize the recently described allergens responsible for allergic contact dermatitis due to ophthalmic drugs and contact lens solutions, and emphaage the need on how to perform diagnostic testing in this special clinical entity.
March 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28614110/contact-sensitization-due-to-allergens-in-nail-cosmetics-identification-treatment-and-prevention
#5
Margaret Chou, Nikhil Dhingra, Tamara Lazic Strugar
Ingredients found in the nail cosmetic industry, including but not limited to methacrylate and acrylate monomers, formaldehyde, and toluene sulfonamide-formaldehyde resin, can incite allergic contact dermatitis. An eczematous outbreak presents on areas surrounding the nail plate and may spread through contact transfer of the allergen, commonly to the face and neck. Even components that were originally deemed nonsensitizing, such as the ubiquitous cyanoacrylate adhesive family, have been found to be allergenic...
June 13, 2017: Dermatitis
https://www.readbyqxmd.com/read/28612445/severe-eyelid-allergic-contact-dermatitis-secondary-to-eyelash-tint-two-case-reports
#6
Lareb Ali, Jonathan S Foulds, Sharizan Abdul Ghaffar
No abstract text is available yet for this article.
July 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28612442/allergic-contact-dermatitis-caused-by-arbutin-and-dipotassium-glycyrrhizate-in-skin-lightening-products
#7
Naoki Oiso, Megumi Tatebayashi, Yasuko Hoshiyama, Akira Kawada
No abstract text is available yet for this article.
July 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28612439/allergic-contact-dermatitis-caused-by-aftershave-creams-containing-glycyrrhiza-inflata
#8
Laura Wuyts, Tom van Hoof, Julien Lambert, Olivier Aerts
No abstract text is available yet for this article.
July 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28612438/allergic-contact-dermatitis-caused-by-peg-22-dodecyl-glycol-copolymer-in-a-skin-repairing-cream
#9
Emmanuelle Amsler, Reem Al-Raddadi, Camille Frances
No abstract text is available yet for this article.
July 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28612437/allergic-contact-dermatitis-caused-by-pentaerythrityl-tetracaprylate-tetracaprate
#10
Aisha Al Ali, Julie Mireault, Catherine Tremblay, Denis Sasseville
No abstract text is available yet for this article.
July 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28608297/neomycin-polymyxin-b-and-dexamethasone-allergic-reactions-following-periocular-surgery
#11
Nicholas A Moore, Craig N Czyz, Tracy D Carter, Jill A Foster, Kenneth V Cahill
BACKGROUND: The aim of this study was to evaluate the rate of periocular allergic skin reactions to topical neomycin, polymyxin B, and dexamethasone (NPD) ophthalmic ointment. METHODS: A consecutive patient prospective study was performed. A total of 522 patients who had a procedure involving incision of the periocular skin with subsequent postoperative application of NPD ophthalmic ointment were included. Patients were evaluated for signs of allergy at 1 week postoperatively or prior if the patient had complaints...
December 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28603598/eyelid-dermatitis-caused-by-allergic-contact-to-acrylates-in-artificial-nails
#12
Jorge Moreira, Rita Gonçalves, Pedro Coelho, Tiago Maio
Over the past few years, there has been an increase in cases of allergic contact dermatitis caused by acrylates, because of the growing popularity of artificial nails. Pathological reactions to artificial nails typically occur on or around the nail area. Eyelid contact dermatitis due to artificial nails is rarely seen, especially in a nonoccupational setting. The authors report the case of a 45-year-old female accountant who developed eyelid dermatitis due to artificial nails.
March 13, 2017: Dermatology Reports
https://www.readbyqxmd.com/read/28583370/prostaglandin-e2-stimulates-adaptive-il-22-production-and-promotes-allergic-contact-dermatitis
#13
Calum T Robb, Henry J McSorley, Jinju Lee, Tomohiro Aoki, Cunjing Yu, Siobhan Crittenden, Anne Astier, Jennifer M Felton, Nicholas Parkinson, Adane Ayele, Richard M Breyer, Stephen M Anderton, Shuh Narumiya, Adriano G Rossi, Sarah E Howie, Emma Guttman-Yassky, Richard B Weller, Chengcan Yao
BACKGROUND: Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are both forms of eczema and are common inflammatory skin diseases with a central role of Th22-derived IL-22 in their pathogenesis. Although prostaglandin E2 (PGE2) is known to promote inflammation, little is known about its role in processes related to AD and ACD development, including IL-22 up-regulation. OBJECTIVES: To investigate whether PGE2 has a role in IL-22 induction and development of ACD, which has increased prevalence in patients with AD...
June 2, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28577805/management-of-atopic-hand-dermatitis
#14
REVIEW
Anne-Sofie Halling-Overgaard, Claus Zachariae, Jacob P Thyssen
This article provides an overview of clinical aspects of hand eczema in patients with atopic dermatitis. Hand eczema can be a part of atopic dermatitis itself or a comorbidity, for example, as irritant or allergic contact dermatitis. When managing hand eczema, it is important to first categorize the subtype and identify potential culprit allergens or irritants. First-line therapy should be a combination of emollients and topical corticosteroids; possible alternatives include topical calcineurin inhibitors or coal tar...
July 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28570245/a-descriptive-study-to-explore-the-effect-of-peristomal-skin-complications-on-quality-of-life-of-adults-with-a-permanent-ostomy
#15
Diane Maydick-Youngberg
Approximately 1 million people are living with an ostomy, and 100 000 to 130 000 new ostomies are created each year. The exact incidence and prevalence of complications are unknown but have been reported to be as high as 70% and to affect quality of life (QoL). Using convenience sampling methods, a descriptive study was conducted to explore QoL scores and peristomal complications reported by adults with a permanent ostomy attending the 2009 United Ostomy Associations of America conference. Attendees who had a permanent ileostomy, colostomy, or urostomy; were at least 18 years of age; and able to read and speak English were invited to participate...
May 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28568892/patch-testing-in-patients-with-suspected-cosmetic-dermatitis-a-retrospective-study
#16
Taru Garg, Soumya Agarwal, Ram Chander, Aashim Singh, Pravesh Yadav
BACKGROUND: Growing use of cosmetics has led to an increase in the incidence of allergic contact dermatitis (ACD) to cosmetics. Patch testing helps to confirm allergy to cosmetics and pinpoint the exact offending allergens. AIMS AND OBJECTIVES: The study aimed to find the frequency of positive patch test reactions in cases with suspected ACD to cosmetics, and the common allergens responsible for it. METHODS: This is a retrospective record-based study of 58 patients, with suspected ACD to cosmetics, who had undergone patch testing with Indian standard series and Indian cosmetic and fragrance series from January 2013 to December 2015...
June 1, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28561421/pharmacokinetics-of-transdermal-etofenamate-and-diclofenac-in-healthy-volunteers
#17
Sara Drago, Roger Imboden, Philipp Schlatter, Mirabel Buylaert, Stephan Krähenbühl, Juergen Drewe
Little is known about the course of the plasma concentration and the bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) contained in dermal patches. We compared an etofenamate prototype patch (patent EP 1833471) and a commercially available diclofenac epolamine patch regarding the bioavailability of the active ingredients relative to respective i.m. applications and regarding their plasma concentration-time course. Twenty-four healthy human volunteers were treated using a parallel group design (n=12 per group) with a single dermal patch (removed after 12 hr) followed (after a latency of 48 hr) by 8 consecutive dermal patches every 12 hr to reach steady-state conditions...
May 31, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28554661/using-dr52c-ni-2-mimotope-tetramers-to-detect-ni-2-reactive-cd4-t-cells-in-patients-with-joint-replacement-failure
#18
Yan Zhang, Yang Wang, Kirsten Anderson, Andrey Novikov, Zikou Liu, Karin Pacheco, Shaodong Dai
T cell mediated hypersensitivity to nickel (Ni(2+)) is one of the most common causes of allergic contact dermatitis. Ni(2+)sensitization may also contribute to the failure of Ni(2+) containing joint implants, and revision to non-Ni(2+) containing hardware can be costly and debilitating. Previously, we identified Ni(2+) mimotope peptides, which are reactive to a CD4(+) T cell clone, ANi2.3 (Vα1, Vβ17), isolated from a Ni(2+) hypersensitive patient with contact dermatitis. This T cell is restricted to major histocompatibility complex class II (MHCII) molecule, Human Leukocyte Antigen (HLA)-DR52c (DRA, DRB3*0301)...
May 26, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28548971/allergic-contact-dermatitis-in-preservatives-current-standing-and-future-options
#19
Gustavo Deza, Ana M Giménez-Arnau
PURPOSE OF REVIEW: Preservatives are well known skin sensitizers and represent one of the main causes of contact allergy. The purpose of this article is to review the current state of contact sensitization induced by preservatives and point future alternatives for products' preservation. RECENT FINDINGS: Isothiazolinones currently are the most common preservatives responsible of contact allergy in Europe and in the United States, and although some regulatory interventions have been taken place, the current contact allergy outbreak is not yet under control...
May 25, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28543809/practice-patterns-of-dermatologists-in-the-pediatric-contact-dermatitis-registry
#20
Sharon E Jacob, Michael B Lipp, Eric Suh, Alina Goldenberg
BACKGROUND/OBJECTIVES: U.S. adults and children are equally likely to have allergic contact dermatitis. Historically the narrow geographic location of data-reporting providers has quantitatively and qualitatively limited the pediatric contact dermatitis data. The Pediatric Contact Dermatitis Registry was used to evaluate self-identified pediatric patch test providers within the United States with regard to demographic characteristics, geographic location, and practice patterns. METHODS: A wide range of U...
May 23, 2017: Pediatric Dermatology
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