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Allergic contact dermatitis

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https://www.readbyqxmd.com/read/29457485/atopy-associated-with-positive-patch-test-and-possible-allergic-contact-dermatitis
#1
Mark G Kirchhof, Gillian C de Gannes
BACKGROUND: Atopy is a genetic predisposition to the development of allergic reactions and the increased production of immunoglobulin E (IgE) upon exposure to environmental antigens. Clinical manifestations of atopy include asthma, atopic dermatitis (AD), and allergic rhinoconjunctivitis (ARC). OBJECTIVE: To determine if cutaneous delayed hypersensitivity reactions (CDHRs) as assessed by patch testing are higher among patients with a history of atopy and with a familial predisposition to atopy...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29453524/a-nonsteroidal-novel-formulation-targeting-inflammatory-and-pruritus-related-mediators-modulates-experimental-allergic-contact-dermatitis
#2
William C Gordon, Virginia García López, Surjyadipta Bhattacharjee, David Rodríguez Gil, Javier Alcover Díaz, Fernando Pineda de la Losa, Ricardo Palacios Peláez, Concha Tiana Ferrer, Gabriela Silvina Bacchini, Bokkyoo Jun, Hélène Varoqui, Nicolas G Bazan
INTRODUCTION: A major clinical challenge in treating allergic contact dermatitis (ACD) is that the first line of treatment is based on the use of corticosteroids. In this study, we aimed to develop a formulation that is devoid of steroids. METHODS: We used mouse ears treated with dinitrofluorobenzene (DNFB) to induce ACD. The efficacy of the test formulation to ameliorate and to prevent induced ACD was determined. RESULTS: To treat this experimentally induced ACD, we developed a formulation containing BIPxine (a mixture of Rosa moschata and Croton lechleri (antioxidants) and Aloe vera and D-panthenol (moisturizers), and hydroglycolic solutions of disodium cromoglycate...
February 16, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29446120/a-novel-case-of-a-brush-with-discomfort-allergic-contact-dermatitis-caused-by-mercaptobenzothiazole-in-rubber-components-of-a-toothbrush
#3
Emily Forward, Victoria Harris, Saxon D Smith
No abstract text is available yet for this article.
February 15, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29440874/clinical-potential-of-mechlorethamine-gel-for-the-topical-treatment-of-mycosis-fungoides-type-cutaneous-t-cell-lymphoma-a-review-on-current-efficacy-and-safety-data
#4
REVIEW
Kendall Liner, Celeste Brown, Laura Y McGirt
Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. The authors in this review found that while the gel formulation may result in a decrease of allergic contact dermatitis, this advantage has been replaced by a higher number of irritant contact reactions and a decrease in complete response rate...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29430710/possible-role-of-regional-variation-in-allergic-contact-dermatitis-case-report
#5
Austin Jiang, Joel C Harrison, Paul D Siegel, Howard Maibach
No abstract text is available yet for this article.
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29430708/allergic-contact-dermatitis-caused-by-topical-ketoconazole-a-relevant-issue-review-of-ketoconazole-positive-patch-tests
#6
Rosana Lazzarini, Mariana F S Hafner, Barbara A F Miguel, Nathalia T Kawakami, Beatriz H Y Nakagome
No abstract text is available yet for this article.
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29430705/allergic-contact-dermatitis-resulting-from-cetyl-peg-ppg-10-1-dimethicone-in-a-deodorant-cream
#7
María-Antonia Pastor-Nieto, María-Elena Gatica-Ortega, Francisco-De-Asís Alcántara-Nicolás, Raquel Pérez-Mesonero, Rocío Gil-Redondo, Eva Martín-Alcalde, Esther De Eusebio
No abstract text is available yet for this article.
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29423962/systemic-allergic-contact-dermatitis-associated-with-topical-diltiazem-and-or-cinchocaine
#8
Luis Santiago, Ana Luísa Moura, Inês Coutinho, Margarida Gonçalo
Topical anesthetics for the treatment of anal fissures or hemorrhoids are a frequent cause of allergic contact dermatitis (ACD) in the perianal region1 . Since 2009, a few cases have been reported also to the calcium channel blocker diltiazem2,3,4 used as a first-line agent in the treatment of anal fissures. We present a case of ACD from diltiazem and/or cinchocaine followed by systemic contact dermatitis (SCD). This article is protected by copyright. All rights reserved.
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29416104/signs-of-atopic-dermatitis-and-contact-dermatitis-affected-by-distinct-h2-haplotype-in-the-nc-nga-genetic-background
#9
Kozo Ohkusu-Tsukada, Daiki Ito, Yuki Okuno, Teruyo Tsukada, Kimimasa Takahashi
We recently advocated in favour of naming a novel H2-haplotype consisting of Kd , D/Ldm7 , I-Ak and I-Ek in the atopic dermatitis (AD) mouse model NC/Nga as "H-2nc ." The role of the H2-haplotype in AD development was investigated in H2b -congenic NC/Nga mice (NC.h2b/b and NC.h2b/nc ) established by backcrossing. A severe 2,4-dinitrofluorobenzene (DNFB)-induced dermatitis in NC/Nga was alleviated partially in NC.h2b/nc and significantly in NC.h2b/b . The AD phenotype was correlated with thymic stromal lymphopoietin (TSLP)-epidermal expression levels and serum levels of total IgE and IL-18/IL-33...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29404871/involvement-of-the-negative-feedback-of-il-33-signaling-in-the-anti-inflammatory-effect-of-electro-acupuncture-on-allergic-contact-dermatitis-via-targeting-microrna-155-in-mast-cells
#10
Zhigang Wang, Tao Yi, Man Long, Fengmin Ding, Lichen Ouyang, Zebin Chen
In this study, we aimed to investigate the effect of electro-acupuncture (EA) at the Zusanli acupoint (ST36) on interleukin (IL)-33-mediated mast cell activation. Firstly, 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) in rats was developed with or without EA treatment. Then, rat peritoneal mast cells (RPMCs) were obtained and cultured in the presence of IL-33. EA treatment relieved ear swelling and reduced mast cell infiltration in the local inflammation area with DNFB challenge, accompanying the decrement of IL-33 production...
February 5, 2018: Inflammation
https://www.readbyqxmd.com/read/29399806/occupational-allergic-contact-dermatitis-caused-by-antibiotics-in-healthcare-workers%C3%A2-%C3%A2-relationship-with-non-immediate-drug-eruptions
#11
Vítor Pinheiro, Catarina Pestana, André Pinho, Isabel Antunes, Margarida Gonçalo
BACKGROUND: Occupational allergic contact dermatitis (ACD) in healthcare workers (HCWs) is common, but systemic antibiotics are rarely reported as the cause. OBJECTIVES: Characterize occupational ACD by handling systemic antibiotics. METHOD: A retrospective analysis was performed of ACD caused by systemic antibiotics among HCWs patch tested between 2010 and 2016 with a series of systemic antibiotics. RESULTS: We studied 4 female nurses aged 28-47 years who developed ACD while working in surgical departments...
February 5, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29397373/the-journal-of-allergy-and-clinical-immunology-in%C3%A2-practice-2017-year-in-review
#12
REVIEW
Michael Schatz, Scott H Sicherer, Robert S Zeiger
An impressive number of clinically impactful studies and reviews were published in The Journal of Allergy and Clinical Immunology: In Practice in 2017. As a service to our readers, the editors provide this Year in Review article to highlight and contextualize the advances published over the past year. We include information from articles on asthma, allergic rhinitis, rhinosinusitis, immunotherapy, atopic dermatitis, contact dermatitis, food allergy, anaphylaxis, drug hypersensitivity, urticarial/angioedema, eosinophilic disorders, and immunodeficiency...
January 31, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29393081/kumkum-induced-allergic-contact-dermatitis-are-we-missing-the-actual-culprit
#13
Ashwini Annabathula, S Priya, C R Srinivas
BACKGROUND: Kumkum, made with turmeric and slaked lime along with colour enhancing dyes is known to cause allergic contact dermatitis. The possible contact allergens in kumkum include turmeric, Sudan-1, 4-aminoazobenzene, brilliant lake red R and cananga oil. We report patch test results among patients with suspected contact hypersensitivity to kumkum. OBJECTIVE: To identify the allergen causing kumkum induced allergic contact dermatitis by patch testing and to advise patients about organic kumkum which doesnot contain colour enhancing dyes...
February 2, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29392782/allergic-contact-dermatitis-caused-by-triethylenetetramine-the-glue-is-the-clue
#14
Martina Lambertini, Colombina Vincenzi, Sandra Lorenzi, Bianca M Piraccini, Michelangelo La Placa
No abstract text is available yet for this article.
February 2, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29380012/lymphocyte-surface-markers-and-cytokines-are-suitable-for-detection-and-potency-assessment-of-skin-sensitizing-chemicals-in-an-in-vitro-model-of-allergic-contact-dermatitis-the-lcsa-ly
#15
Janna Frombach, Anna Sonnenburg, Björn-Dirk Krapohl, Torsten Zuberbier, Matthias Peiser, Ralf Stahlmann, Maximilian Schreiner
Allergic contact dermatitis is a widespread health disorder and occupational skin disease. Hence, screening for contact-sensitizing chemicals is highly relevant to toxicology, dermatology, and occupational medicine. The use of animal tests for this purpose is constrained by ethical considerations, need for high-throughput screening, and legislation (e.g., for cosmetics in the European Union). T cell activation is the final and most specific key event of the "adverse outcome pathway" for skin sensitization and therefore a promising target for the development of in vitro sensitization assays...
January 30, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29341989/a-private-case-of-allergic-contact-dermatitis
#16
Heidi Nyhoff
No abstract text is available yet for this article.
February 16, 2018: Nurse Practitioner
https://www.readbyqxmd.com/read/29341188/allergic-contact-dermatitis-caused-by-hydroxyacetophenone-in-a-face-cream
#17
Tatiana Sanz-Sánchez, Ricardo Valverde Garrido, Paola Maldonado Cid, Rosa M Díaz-Díaz
No abstract text is available yet for this article.
February 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29341184/first-report-of-allergic-contact-dermatitis-caused-by-sorbitan-caprylate
#18
Joke Vandeweghe, Eveline Decoster, Hilde Lapeere
No abstract text is available yet for this article.
February 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29341182/allergic-contact-dermatitis-caused-by-olanedine%C3%A2-olanexidine-gluconate-a-new-antiseptic
#19
Hiroshi Nagai, Hitoshi Fukuda
No abstract text is available yet for this article.
February 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29334799/potential-of-epr-spin-trapping-to-investigate-in-situ-free-radicals-generation-from-skin-allergens-in-reconstructed-human-epidermis-cumene-hydroperoxide-as-proof-of-concept
#20
Salen Kuresepi, Bertrand Vileno, Philippe Turek, Jean-Pierre Lepoittevin, Elena Giménez-Arnau
The first step in the development of skin sensitisation to a chemical, and in the elicitation of further allergic contact dermatitis (ACD), is the binding of the allergen to skin proteins after penetrating into the epidermis. The so-formed antigenic adduct is then recognised by the immune system as foreign to the body. Sensitising organic hydroperoxides derived from autoxidation of natural terpenes are believed to form antigens through radical-mediated mechanisms, although this has not yet been established...
January 15, 2018: Free Radical Research
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