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Allergic contact dermatitis

Charlotte Rodrigues Neves, Susan Gibbs
Contact with the skin is inevitable or desirable for daily life products such as cosmetics, hair dyes, perfumes, drugs, household products, and industrial and agricultural products. Whereas the majority of these products are harmless, a number can become metabolized and/or activate the immunological defense via innate and adaptive mechanisms resulting in sensitization and allergic contact dermatitis upon following exposures to the same substance. Therefore, strict safety (hazard) assessment of actives and ingredients in products and drugs applied to the skin is essential to determine I) whether the chemical is a potential sensitizer and if so II) what is the safe concentration for human exposure to prevent sensitization from occurring...
June 23, 2018: Current Topics in Microbiology and Immunology
Ryan Ladd, Mirna Becevic, Hope Misterovich, Karen Edison
Allergic contact dermatitis (ACD) is a common dermatologic disorder that is estimated to affect 15-20% of the general population. Because of its prevalence, it may be expected that ACD should be easily recognized. However, it can present with many clinical variations that may complicate diagnosis. Although ACD is a treatable condition, patients from rural and underserved areas suffer if timely access to specialty care is limited. Dermatology Extension for Community Healthcare Outcomes (Dermatology ECHO) telemedicine sessions were created to mentor rural primary care providers (PCPs)...
January 1, 2018: Journal of Telemedicine and Telecare
JiaDe Yu, Amber Reck Atwater, Bruce Brod, Jennifer K Chen, Sarah S Chisolm, David E Cohen, Salma de la Feld, Anthony A Gaspari, Kari Lyn Martin, Marjorie Montanez-Wiscovich, Michael Sheehan, Nanette Silverberg, Aida Lugo-Somolinos, Binod K Thakur, Kalman Watsky, Sharon E Jacob
BACKGROUND: Allergic contact dermatitis is a challenging diagnostic problem in children. Although epicutaneous patch testing is the diagnostic standard for confirmation of contact sensitization, it is less used in children by dermatologists treating children, pediatric dermatologists, and pediatricians, when compared with adult practitioners. OBJECTIVE: The aim of the study was to create and evaluate standardization of a pediatric patch test series for children older than 6 years...
June 21, 2018: Dermatitis
Alix Danoy, Howard I Maibach
Frequent allergens are known, but not whether allergens are enantiomer specific. Chemicals were tested on guinea pigs and humans to answer this question. Frullanoides showed evident allergic enantiospecificity, whereas the conclusion was shaded for α-methylene-γ-butyrolactone. A link between this chemical and chronic actinic dermatitis was proposed. No clear tendency to enantio-stereospecificity in inducing allergic contact dermatitis was ascertained. Future studies using contemporary analytical chemistry and new immunologic knowledge have to be undertaken to provide clearer mechanistic insights...
June 21, 2018: Dermatitis
Erin Foster, Christina Nguyen, Patricia Norris
No abstract text is available yet for this article.
June 21, 2018: Dermatitis
Rosana Lazzarini, Mariana de Figueiredo Silva Hafner, Mayara Gomes Rangel
Children's products are considered safe by the general population and doctors. Labels with terms such as "hypoallergenic" or "dermatologically recommended and tested" denote trust and credibility with the idea that they can be used by any individual. Patients with allergic contact dermatitis may be sensitive to allergens present in any product, including children's. There is insufficient knowledge about allergens in these products in our country. We evaluated 254 children's products, and at least one allergen was present in 236 (93%) of them...
June 2018: Anais Brasileiros de Dermatologia
Soogan C Lalla, Henry Nguyen, Hafsa Chaudhry, Jill M Killian, Lisa A Drage, Mark D P Davis, James A Yiannias, Matthew R Hall
BACKGROUND: Propylene glycol (PG) is a solvent, vehicle, and humectant being used increasingly in a wide array of personal care products, cosmetics, and topical medicaments. Propylene glycol is a recognized source of both allergic and irritant contact dermatitis. OBJECTIVE: The aim of the study was to report incidence of positive patch tests to PG at Mayo Clinic. METHODS: We retrospectively reviewed records of all patients patch tested to PG from January 1997 to December 2016...
June 19, 2018: Dermatitis
Nicola Milanesi, Massimo Gola, Stefano Francalanci
No abstract text is available yet for this article.
June 20, 2018: Contact Dermatitis
A I Lorente, M T Miranda, C V Rojas, C Almeida, P Mozo, R Lorente
The face is a body area exposed to many foreign substances and it is a frequent location for allergic contact dermatitis (ACD). The diagnosis of facial dermatitis (FD) is complex because other dermatological and systemic diseases must be considered. This article is protected by copyright. All rights reserved.
June 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Nils Hamnerius, Cecilia Svedman, Ola Bergendorff, Jonas Björk, Magnus Bruze, Malin Engfeldt, Ann Pontén
BACKGROUND: Hand eczema (HE) in healthcare workers (HCWs) is common. Besides wet work, healthcare work also implies exposure to contact allergens. OBJECTIVES: To assess HE and contact allergy related to occupational exposures in HCWs. METHODS: In a cross-sectional study, 311 HCWs with HE within the preceding 12 months and a control group of 114 HCWs without HE were investigated with the baseline series and a special patch test series based on substances found in the gloves, soaps, alcoholic hand disinfectants and hand creams provided at the hospitals...
June 20, 2018: Contact Dermatitis
A S Darrigade, C Léauté-Labrèze, F Boralevi, A Taïeb, B Milpied
BACKGROUND: Contact dermatitis from topical antiseptic use has been reported mostly in adults but rare cases of chlorhexidine contact dermatitis have also been described in young children. OBJECTIVE: To evaluate contact allergic dermatitis to antiseptics in young children. METHODS: The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an antiseptics series and the personal topical products used...
June 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Francesca Larese Filon, Francesca Rui
OBJECTIVES: Occupational contact dermatitis are the second occupational diseases in industrialized countries and the preventive action and/or early diagnosis done by occupational physician (OP) is of paramount importance. METHODS: OP in the process of risk evaluation must suggest products, detergents and personal protective equipment with low irritant or sensitization potential. During work, the use of skin creams has to be promoted to prevent irritation that is the first step towards impairment of the skin barrier and sensitization...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Mariana Cruz-Manzano, Cristina N Brau-Javier, Sheila Valentín-Nogueras, Luz D Figueroa-Guzmán
OBJECTIVE: To characterize and analyze the inpatient and emergency pediatric dermatology consults in our academic hospital center. METHODS: We reviewed 485 consultations that were done by the University of Puerto Rico Department of Dermatology from July 2007 to June 2012. The date, patient age and gender, consulting service, presumptive diagnosis, final diagnosis, and diagnostic procedures performed were documented for each consult. RESULTS: The patients' ages ranged from newborn to 18 years; the 13 to 18 years age group was the most common (29%)...
June 2018: Puerto Rico Health Sciences Journal
Xiaoyun Xu, Wei Xiao, Zhe Zhang, Jianhao Pan, Yixi Yan, Tao Zhu, Dan Tang, Kaihe Ye, Manish Paranjpe, Lintao Qu, Hong Nie
BACKGROUND: Allergic contact dermatitis (ACD) is a highly prevalent inflammatory disease of the skin. As a result of the complex etiology in ACD, therapeutic compounds targeting refractory pruritus in ACD lack efficacy and lead to numerous side effects. OBJECTIVE: In this study, we investigated the anti-pruritic effects of oxymatrine (OMT) and explored its mechanism of action in a mouse model of ACD. METHOD: 72 male SPF C57BL/6 mice were randomly divided into control group, ACD model group, dexamethasone positive control group (0...
May 31, 2018: Journal of Dermatological Science
Anna E Kersh, Stephen Helms, Salma de la Feld
Hand dermatitis is a common condition with a lifetime prevalence of 20%. Glove allergic contact dermatitis (ACD) is a very important dermatitis affecting health care workers, hairdressers, cleaning personnel, kitchen workers, craftsmen, construction workers, laboratory workers, and homemakers. Occupationally related cases may be severe and can result in significant disability. Glove ACD is most commonly due to exposure to rubber accelerators, which are compounds that are added to rubber during production to increase strength and durability...
January 2018: Dermatitis
Elena Garcia-Hidalgo, Dovilé Schneider, Natalie von Goetz, Christiaan Delmaar, Michael Siegrist, Konrad Hungerbühler
Consumers regularly use household care and personal care products (HC&PCPs). Isothiazolinones are included in HC&PCPs as preservatives and are being held responsible for an epidemic rise in allergic contact dermatitis (ACD). The objective of this study was to assess the origin and extent of dermal exposure in order to evaluate the risk of ACD from isothiazolinones in HC&PCP. Individual-based aggregate dermal exposure to four isothiazolinones was estimated using the newly proposed Probabilistic Aggregated Consumer Exposure Model-Kinetic, Dermal (PACEM-KD) by combining the reported individual use patterns for HC&PCP in Switzerland (N = 669 (558 adults), ages 0-91) with isothiazolinone concentrations measured in products used by the individual person...
June 9, 2018: Environment International
Ivone Jakasa, Jacob P Thyssen, Sanja Kezic
Skin diseases represent one of the most common work-related diseases and may have a detrimental effect on social, personal and occupational aspects of life. Contact dermatitis, which comprises predominately irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) accounts for vast majority of occupational skin diseases, especially in occupations associated with frequent skin contact with irritants and contact allergens. Although ICD and ACD have similar clinical manifestation, their pathophysiology and the role of the skin barrier is different...
June 12, 2018: Experimental Dermatology
Takashi Hashimoto, Jordan D Rosen, Kristen M Sanders, Gil Yosipovitch
Basophils are blood granulocytes and normally constitute less than 1% of blood peripheral leukocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Basophils may be involved in itch through the mediation of a Th2 immune response, interaction with other cells in the skin, and secretion of a wide variety of itch-related mediators, e...
June 12, 2018: Experimental Dermatology
Lien Mestach, Sara Huygens, An Goossens, Liesbeth Gilissen
BACKGROUND: Acrylates and methacrylates are acrylic resin monomers that are known to induce skin sensitization as a result of their presence in different materials, such as nail cosmetics, dental materials, printing inks, and adhesives. Allergic contact dermatitis resulting from the use of modern wound dressings containing them has only rarely been reported. OBJECTIVES: To describe 2 patients who developed allergic contact dermatitis caused by acrylic-based modern medical dressings and/or adhesives...
June 11, 2018: Contact Dermatitis
Haudrey Assier, Florence Tetart, Martine Avenel-Audran, Annick Barbaud, Marie-Christine Ferrier-le Bouëdec, Françoise Giordano-Labadie, Brigitte Milpied, Emmanuelle Amsler, Evelyne Collet, Pascal Girardin, Angèle Soria, Julie Waton, François Truchetet, Jean-Luc Bourrain, Gwendeline Gener, Claire Bernier, Nadia Raison-Peyron
BACKGROUND: Eyelids are frequent sites of contact dermatitis. No prospective study focused on eyelid allergic contact dermatitis (EACD) has yet been published, and this topic has never been studied in French patients. OBJECTIVES: To prospectively evaluate the usefulness of an eyelid series in French patients patch tested because of EACD, and to describe these patients. METHODS: We prospectively analysed standardized data for all patients referred to our departments between September 2014 and August 2016 for patch testing for suspected EACD as the main reason...
June 8, 2018: Contact Dermatitis
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