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Rotator cuff tendinopathy

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https://www.readbyqxmd.com/read/28634854/micrornas-associated-with-inflammation-in-shoulder-tendinopathy-and-glenohumeral-arthritis
#1
Finosh G Thankam, Chandra S Boosani, Matthew F Dilisio, Devendra K Agrawal
Inflammation is associated with glenohumeral arthritis and rotator cuff tendon tears. Epigenetically, miRNAs tightly regulate various genes involved in the inflammatory response. Alterations in the expression profile of miRNAs and the elucidation of their target genes with respect to the pathophysiology could improve the understanding of their regulatory role and therapeutic potential. Here, we screened key miRNAs that mediate inflammation and linked with JAK2/STAT3 pathway with respect to the coincidence of glenohumeral arthritis in patients suffering from rotator cuff injury (RCI)...
June 20, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28613120/rotator-cuff-calcific-tendinopathy-randomized-comparison-of-us-guided-percutaneous-treatments-by-using-one-or-two-needles
#2
Davide Orlandi, Giovanni Mauri, Francesca Lacelli, Angelo Corazza, Carmelo Messina, Enzo Silvestri, Giovanni Serafini, Luca Maria Sconfienza
Purpose To determine whether the use of one or two needles influences procedure performance and patient outcomes for ultrasonography (US)-guided percutaneous irrigation of calcific tendinopathy. Materials and Methods Institutional review board approval and written informed patient consent were obtained. From February 2012 to December 2014, 211 patients (77 men and 134 women; mean age, 41.6 years ± 11.6; range, 24-69 years) with painful calcific tendinopathy diagnosed at US were prospectively enrolled and randomized...
June 14, 2017: Radiology
https://www.readbyqxmd.com/read/28597729/effects-of-high-and-low-energy-radial-shock-waves-therapy-combined-with-physiotherapy-in-the-treatment-of-rotator-cuff-tendinopathy-a-retrospective-study
#3
Xiangzheng Su, Zhongli Li, Zhengsheng Liu, Teng Shi, Chao Xue
PURPOSE: The aim of this study was to investigate the efficacy of high- and low-energy radial shock waves combined with physiotherapy for rotator cuff tendinopathy patients. METHODS: Data from rotator cuff tendinopathy patients received high- or low-energy radial shock waves combined with physiotherapy or physiotherapy alone were collected. The Constant and Murley score and visual analog scale score were collected to assess the effectiveness of treatment in three groups at 4, 8, 12, and 24 weeks...
June 9, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28595162/rotator-cuff-tendinopathy-alters-the-muscle-activity-onset-and-kinematics-of-scapula
#4
Hio Teng Leong, Gabriel Yin-Fat Ng, Shing Chung Chan, Siu Ngor Fu
Athletes with rotator cuff (RC) tendinopathy demonstrate an aberrant pattern of scapular motion which might relate to deficits in the scapular muscles. This study aimed to determine whether alteration in scapular kinematics is associated with deficits in the activity onset of scapular muscles. Forty-three male volleyball players (17 asymptomatic and 26 with RC tendinopathy) joined the study. Three-dimensional scapular kinematics was quantified using an acromial marker cluster method. The activity onset of the upper (UT), middle (MT), and lower trapezius (LT), and serratus anterior (SA) during arm abduction was assessed with electromyography...
May 30, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28566400/arthroscopic-decompression-not-recommended-in-the-treatment-of-rotator-cuff-tendinopathy-a-final-review-of-a-randomised-controlled-trial-at-a-minimum-follow-up-of-ten-years
#5
S Ketola, J T Lehtinen, I Arnala
AIMS: Rotator cuff tendinopathy has a multifactorial origin. Rejecting the mechanistic theory has also led to abandoning operative treatment at initial presentation in the first line. Physiotherapy exercise programmes are the accepted first line treatment. The aim of this study was to assess the long-term additional benefits of subacromial decompression in the treatment of rotator cuff tendinopathy. PATIENTS AND METHODS: This randomised controlled trial of 140 patients (52 men, 88 women, mean age 47...
June 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28560466/real-life-effectiveness-of-spa-therapy-in-rheumatic-and-musculoskeletal-diseases-a-retrospective-study-of-819-patients
#6
Mine Karagülle, Sinan Kardeş, Müfit Zeki Karagülle
The objective of this study is to determine the use and efficacy of spa therapy in patients with a wide spectrum of rheumatic and musculoskeletal diseases under real-life clinical practice circumstances. In this retrospective observational study at the Medical Ecology and Hydroclimatology Department of Istanbul Faculty of Medicine, the records of all adult patients with rheumatic and musculoskeletal diseases who were prescribed a spa therapy in various health resorts in Turkey between 2002 and 2012 were analyzed...
May 30, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28560137/management-of-rotator-cuff-defects-after-calcific-tendinopathy-debridement-using-a-bioinductive-collagen-implant
#7
Sean McMillan, Elizabeth Ford
The management of rotator cuff defects after arthroscopic debridement for calcific tendinitis can be a challenge for physicians. To date, treatment options have included debridement alone, in situ repairs of the tendon, or full-thickness takedown and repair. Each option, however, has been fraught with its own pitfalls and limitations. We propose a technique for the management of rotator cuff defects through the application of a bioinductive collagen implant that may allow for rapid tissue incorporation and regeneration...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28542244/a-quantitative-label-free-analysis-of-the-extracellular-proteome-of-human-supraspinatus-tendon-reveals-damage-to-the-pericellular-and-elastic-fibre-niches-in-torn-and-aged-tissue
#8
Osnat Hakimi, Nicola Ternette, Richard Murphy, Benedikt M Kessler, Andrew Carr
Tears of the human supraspinatus tendon are common and often cause painful and debilitating loss of function. Progressive failure of the tendon leading to structural abnormality and tearing is accompanied by numerous cellular and extra-cellular matrix (ECM) changes in the tendon tissue. This proteomics study aimed to compare torn and aged rotator cuff tissue to young and healthy tissue, and provide the first ECM inventory of human supraspinatus tendon generated using label-free quantitative LC-MS/MS. Employing two digestion protocols (trypsin and elastase), we analysed grain-sized tendon supraspinatus biopsies from older patients with torn tendons and from healthy, young controls...
2017: PloS One
https://www.readbyqxmd.com/read/28435563/ultrasound-guided-percutaneous-lavage-in-the-treatment-of-calcific-tendinopathy-of-elbow-extensor-tendons-a-case-report
#9
M Abate, V Salini, C Schiavone
We report the efficacy of the ultrasound-guided percutaneous treatment in the management of elbow extensor tendons calcific tendinopathy. The ultrasound-guided percutaneous treatment is broadly used with positive results in patients suffering from rotator cuff calcific tendinopathy. However, this interventional method has been reported only in one patient in the medical literature. A 34 years-old female who complained pain, swelling and severe functional limitation of the right elbow was referred to our unit...
July 2016: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28369181/apoptosis-and-rotator-cuff-tears-scientific-evidence-from-basic-science-to-clinical-findings
#10
Leonardo Osti, Matteo Buda, Angelo Del Buono, Raffaella Osti, Leo Massari, Nicola Maffulli
Introduction: Excessive apoptosis has been hypothesized as possible cause of tendinopathy and tear in the tendons of the rotator cuff (RC). Different mechanisms and molecules play a key role in cell regulation. Biological interventions can affect the process of apoptosis to control the tendinopathy process, and may be useful to design new treatments. Source of data: We identified basic science, in vitro and in vivo preclinical and clinical studies listed in the Pubmed Google Scholar, CINAHL, Cochrane Central and Embase Biomedical databases in English, Spanish, Italian and French concerning the effects of apoptosis on RC tendons...
June 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28266691/resorbable-electrospun-polydioxanone-fibres-modify-the-behaviour-of-cells-from-both-healthy-and-diseased-human-tendons
#11
A Kendal, S Snelling, S Dakin, E Stace, P-A Mouthuy, A Carr
Chronic tendinopathy in an active and ageing population represents an increasing burden to healthcare systems. Rotator cuff tendinopathy alone accounts for approximately 70 % of all shoulder pain. Tendinopathic tissue has a disorganised extracellular matrix, altered vasculature, and infiltration of fibroblasts and inflammatory cells. This altered biology may contribute to the limited success of surgical repair strategies. Electrospun resorbable scaffolds can potentially enhance endogenous repair mechanisms by influencing the tissue microenvironment...
February 20, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28197744/efficiency-of-quantitative-echogenicity-for-investigating-supraspinatus-tendinopathy-by-the-gray-level-histogram-of-two-ultrasound-devices
#12
Jiun-Cheng Hsu, Po-Han Chen, Kuo-Chin Huang, Yao-Hung Tsai, Wei-Hsiu Hsu
PURPOSE: The gray-level histogram of ultrasound is a promising tool for scanning the hypoechogenic appearance of supraspinatus tendinopathy, and the aim of this study was to test the hypothesis that the gray-level value of the supraspinatus tendon in the painful shoulder has a lower value on B-mode images even though in different ultrasound devices. METHODS: Sixty-seven patients who had unilateral shoulder pain with rotator cuff tendinopathy underwent bilateral shoulder ultrasonography, and we compared the mean gray-level values of painful shoulders and contralateral shoulders without any pain in each patient using two ultrasound devices...
February 14, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28185130/frequency-of-shoulder-corticosteroid-injections-for-pain-and-stiffness-after-shoulder-surgery-and-their-potential-to-enhance-outcomes-with-physiotherapy-a-retrospective-study
#13
John G Skedros, Micheal G Adondakis, Alex N Knight, Michael B Pilkington
INTRODUCTION: What is the rate of injecting patients with shoulder corticosteroid injections to alleviate excessive stiffness and pain within 6 months after shoulder surgery? METHODS: Retrospective 10-year review of a shoulder surgeon's practice. Participants included 754 patients who had 945 non-arthroplasty shoulder surgeries. Outcome measures included the rate of injections, diagnoses, patient characteristics, and efficacy via questionnaire. RESULTS: Approximately one in five patients received a subacromial and/or glenohumeral corticosteroid injection...
June 2017: Pain and Therapy
https://www.readbyqxmd.com/read/28105983/effect-of-bone-marrow-aspirate-concentrate-platelet-rich-plasma-on-tendon-derived-stem-cells-and-rotator-cuff-tendon-tear
#14
Sun Jeong Kim, Da Hyun Song, Jong Wook Park, Silvia Park, Sang Jun Kim
Bone marrow aspirate concentrates (BMACs) and platelet-rich plasma (PRP) are good sources to control the differentiation of tendon-derived stem cells (TDSCs), but there has been no study about the effect of the BMAC-PRP complex on TDSCs and tendinopathy. The aim of this study was to investigate the effect of BMAC-PRP on the TDSCs and to find the therapeutic effect of BMAC-PRP on the rotator cuff tendon tear. The chondrogenic and osteogenic potential of TDSCs decreased, but the adipogenic potential of TDSCs revealed no significant difference when they were cocultured with BMAC-PRP...
May 9, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28077355/no-evidence-for-the-use-of-stem-cell-therapy-for-tendon-disorders-a-systematic-review
#15
Haiko I M F L Pas, Maarten H Moen, Hidde J Haisma, Marinus Winters
INTRODUCTION: Stem cells have emerged as a new treatment option for tendon disorders. We systematically reviewed the current evidence for stem cell therapy in tendon disorders. METHODS: Randomised and non-randomised controlled trials, cohort studies and case series with a minimum of 5 cases were searched in MEDLINE, CENTRAL, EMBASE, CINAHL, PEDro and SPORTDiscus. In addition, we searched grey literature databases and trial registers. Only human studies were included and no time or language restrictions were applied to our search...
January 11, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28061032/effects-of-platelet-rich-plasma-with-concomitant-use-of-a-corticosteroid-on-tenocytes-from-degenerative-rotator-cuff-tears-in-interleukin-1%C3%AE-induced-tendinopathic-conditions
#16
Chris Hyunchul Jo, Seung Yeon Lee, Kang Sup Yoon, Sue Shin
BACKGROUND: A corticosteroid injection is commonly used to treat tendinopathy, but it has been associated with negative effects on tendon homeostasis. Platelet-rich plasma (PRP) is known to have proliferative and anabolic effects as well as cytoprotective effects against corticosteroids on tenocytes. However, the combined effects of a corticosteroid and PRP on the anti-inflammatory, matrix synthesis, and cytoprotective potential of tenocytes in conditions simulating tendinopathy have not been investigated...
April 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28002923/tendinopathic-supraspinatus-tenocytes-may-have-a-neuroendocrine-like-function-secreting-cgrp-sp-and-vegf-a-pilot-immunohistochemistry-study
#17
R Sahemey, P Malliaras, J S Lewis, G J Michael, P Shortland, D Morrissey, N Maffulli
We wanted to observe and compare the appearance of neurovascular tissue from tendon ex vivo, in patients with and without painful rotator cuff tendinopathy. Supraspinatus tendons were biopsied from 5 participants with painful tendinopathy and normal tendon from a young male. Slides were stained with haematoxylin and eosin and toluidine blue for histological assessment. Immunohistochemical markers for general nerves (protein gene-product 9.5 and synaptophysin), sensory nerves (calcitonin gene-related peptide; substance-P) and vascularisation (vascular endothelial growth factor) were used...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28002862/ultrasound-guided-percutaneous-irrigation-of-calcific-tendinopathy
#18
Carmelo Messina, Luca Maria Sconfienza
Rotator cuff calcific tendinopathy (RCCT) is a common disease that may cause highly disabling shoulder pain. No treatment is required for asymptomatic calcifications; mild symptoms may be treated conservatively. Among several therapeutic options, ultrasound-guided percutaneous irrigation of calcific tendinopathy (US-PICT) is currently accepted as the first-line safe and effective treatment for RCCT, with significant pain improvement and a very low rate of minor complications. Different approaches have been reported to dissolve calcified deposits, all including the use of a fluid (local anesthetic or saline solution) and the use of one or two needles to inject and retrieve the fluid/dissolved calcium...
November 2016: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28002354/association-between-cardiovascular-disease-risk-factors-and-rotator-cuff-tendinopathy-a-cross-sectional-study
#19
Kara Arnold Applegate, Matthew S Thiese, Andrew S Merryweather, Jay Kapellusch, David L Drury, Eric Wood, Richard Kendall, James Foster, Arun Garg, Kurt T Hegmann
OBJECTIVE: Recent evidence has found potential associations between cardiovascular disease (CVD) risk factors and common musculoskeletal disorders. We evaluated possible associations between risk factors and both glenohumeral joint pain and rotator cuff tendinopathy. METHODS: Data from WISTAH hand study participants (n = 1226) were assessed for associations between Framingham Heart Study CVD risk factors and both health outcomes. RESULTS: A strong association was observed between CVD risk scores and both glenohumeral joint pain and rotator cuff tendinopathy...
February 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27914921/polydeoxyribonucleotide-injection-in-the-treatment-of-chronic-supraspinatus-tendinopathy-a-case-controlled-retrospective-comparative-study-with-6-month-follow-up
#20
Young Chun Yoon, Doo-Hyung Lee, Michael Young Lee, Seung-Hyun Yoon
OBJECTIVE: To determine the efficacy of polydeoxyribonucleotide (PDRN) injection for rotator cuff disease (RCD). DESIGN: Case-controlled, retrospective, comparative study. SETTING: Outpatient clinic at a university-affiliated tertiary care hospital. PARTICIPANTS: Patients (N=106) with chronic nontraumatic refractory RCD who were unresponsive to at least 1 month of conservative treatment: 55 patients received PDRN injection (PDRN group) and 51 continued conservative treatment (control group)...
May 2017: Archives of Physical Medicine and Rehabilitation
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