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palliative radiotherapy

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https://www.readbyqxmd.com/read/28102486/atypical-teratoid-rhabdoid-tumor-in-the-first-year-of-life-the-canadian-atrt-registry-experience-and-review-of-the-literature
#1
Mary Fossey, Haocheng Li, Samina Afzal, Anne-Sophie Carret, David D Eisenstat, Adam Fleming, Juliette Hukin, Cynthia Hawkins, Nada Jabado, Donna Johnston, Tania Brown, Valerie Larouche, Katrin Scheinemann, Douglas Strother, Beverly Wilson, Shayna Zelcer, Annie Huang, Eric Bouffet, Lucie Lafay-Cousin
While 2/3 of patients with ATRT are less than 3 years at diagnosis, the literature suggests younger children present with more aggressive disease and poorer outcome. However, little data exist on characteristics and outcome of patients diagnosed with ATRT in the first year of life. In particular, it is unclear whether they access similar treatments as do older children. We compared the cohort of patients ≤12 months from the Canadian ATRT registry to all cases extracted from the literature reported between 1996 and 2014 to describe their clinical and treatment characteristics, and potential prognostic factors...
January 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28100948/malignant-proliferating-trichilemmal-tumour-of-the-scalp-with-intra-cranial-extension-and-lung-metastasis-a-case-report
#2
Lancelot Lobo, Amol Dilip Amonkar, V V S M Kumar Dontamsetty
Malignant proliferating trichilemmal tumour (MPTT) is a rare cutaneous tumour predominantly affecting the scalp, eyelids, neck and face of elderly women. It is a large, solitary, multilobulated lesion that may arise within a pilar cyst. These tumours are largely benign, often cystic and are characterized by trichilemmal keratinisation. However at times, the tumour has an aggressive clinical course and a propensity for distant metastasis. We report a case of a 29-year-old male who presented with a scalp swelling...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28088975/-palliative-radiotherapy-for-aids-related-diffuse-large-b-cell-lymphoma-a-report-of-six-cases-with-literature-review
#3
K H Yuan, M Zhang, Y J Luo
No abstract text is available yet for this article.
December 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28086959/e-learning-programs-in-oncology-a-nationwide-experience-from-2005-to-2014
#4
Jan Degerfält, Staffan Sjöstedt, Per Fransson, Elisabeth Kjellén, Mads U Werner
BACKGROUND: E-learning is an established concept in oncological education and training. However, there seems to be a scarcity of long-term assessments of E-learning programs in oncology vis-á-vis their structural management and didactic value. This study presents descriptive, nationwide data from 2005 to 2014. E-learning oncology programs in chemotherapy, general oncology, pain management, palliative care, psycho-social-oncology, and radiotherapy, were reviewed from our databases. Questionnaires of self-perceived didactic value of the programs were examined 2008-2014...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28078078/radiotherapy-in-the-management-of-gist-state-of-the-art-and-new-potential-scenarios
#5
L Gatto, M Nannini, M Saponara, V Di Scioscio, G Beltramo, G P Frezza, G Ercolani, A D Pinna, A Astolfi, M Urbini, G Brandi, G Biasco, M A Pantaleo
BACKGROUND: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable or advanced GIST are poorly responsive to conventional cytotoxic chemotherapy but the introduction of tyrosine kinase inhibitors (TKIs) marked a revolutionary step in the treatment of these patients, radically improving prognosis and clinical benefit. Historically GIST has been considered radiation-resistant, and the role of radiotherapy in the management of patients with GIST is currently restricted to symptomatic palliation in current treatment guidelines...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28061538/palliative-radiotherapy-for-skin-malignancies
#6
Winston Vuong, Jessica Lin, Randy L Wei
Palliative radiotherapy (PRT) improves patient quality of life (QoL) through alleviating cancer-associated symptoms such as pain, bleeding, and ulceration. Palliative management of patients with skin malignancies requires consideration of cosmetic and psychosocial outcomes as QoL measures. In this review, we highlight the current literature and advances in the use of PRT for patients with the three most commonly encountered forms of skin malignancies: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma...
December 19, 2016: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28061532/palliative-interventions-for-hepatocellular-carcinoma-patients-analysis-of-the-national-cancer-database
#7
Abdulrahman Y Hammad, Jared R Robbins, Kiran K Turaga, Kathleen K Christians, T Clark Gamblin, Fabian M Johnston
BACKGROUND: Palliative therapies are provided to a subset of hepatocellular carcinoma (HCC) patients with the aim of providing symptomatic relief, better quality of life and improved survival. The present study sought to assess and compare the efficacy of different palliative therapies for HCC. METHODS: The National Cancer Database (NCDB), a retrospective national database that captures approximately 70% of all patients treated for cancer in the US, was queried for patients with HCC who were deemed unresectable from 1998-2011...
November 22, 2016: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28055970/genomic-analysis-of-exceptional-responders-to-radiotherapy-reveals-somatic-mutations-in-atm
#8
Jennifer Ma, Jeremy Setton, Luc Morris, Pedro Blecua Carrillo Albornoz, Christopher Barker, Benjamin H Lok, Eric Sherman, Nora Katabi, Kathryn Beal, Ian Ganly, Simon N Powell, Nancy Lee, Timothy A Chan, Nadeem Riaz
Radiation therapy is a mainstay of cancer treatment, yet the molecular determinants of clinical response are poorly understood. We identified exceptional responders to radiotherapy based on clinical response, and investigated the associated tumor sequencing data in order to identify additional patients with similar mutations. Among head and neck squamous cell cancer patients receiving palliative radiotherapy at our institution, we identified one patient with documented complete metabolic response. Targeted sequencing analysis of the tumor identified a somatic frame-shift mutation in ATM, a gene known to be associated with radio-sensitivity in the germline...
December 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/28053701/primary-thyroid-lymphoma-a-case-report-and-review-of-the-literature
#9
Rita Peixoto, João Correia Pinto, Virgínia Soares, Pedro Koch, António Taveira Gomes
INTRODUCTION: A rapidly enlarging mass of the anterior compartment of the neck with compressive symptoms may represent, among other diagnosis, a neoplasm of the thyroid gland. PRESENTATION OF CASE: We describe the case of a 59-year-old woman referred to the endocrine surgical unit because of compressive cervical symptoms for 3 months. The cervical ultrasound revealed a sub-sternal goiter with heterogeneous echo structure and the fine-needle aspirating cytology was inconclusive...
January 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28052685/occurrence-of-malignancies-after-kidney-transplantation-in-adults-slovak-multicenter-experience
#10
Z Zilinska, M Sersenova, M Chrastina, J Breza Sr, L Bena, T Baltesova, A Jurcina, R Roland, E Lackova, M Cellar, L Laca, I Dedinska
Malignancies are one of the three major causes of renal recipient´s death with a functioning graft after cardiovascular diseases and infections. Among the variety of risk factors, including conventional and specific to transplant recipients, the duration of immunosuppressive therapy, the intensity of therapy, and the type of immunosuppressive agent all have an impact on development of post-transplant malignancy. The aim of our retrospective study was to document the incidence, the type of malignancies, the patient/graft survival in the group of kidney transplant recipients in Slovak Republic, and to identify the factors which influenced the outcome...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28044054/pituitary-metastasis-from-renal-cell-carcinoma-description-of-a-case-report
#11
Chloé Wendel, Marco Campitiello, Francesca Plastino, Nada Eid, Laurent Hennequin, Philippe Quétin, Raffaele Longo
BACKGROUND Pituitary metastasis is uncommon, breast and lung cancers being the most frequent primary tumors. Renal cell carcinoma (RCC) is a rare cause of pituitary metastases, with only a few cases described to date. CASE REPORT We report a case of a 61-year-old man who presented with a progressive deterioration of visual acuity and field associated with a bitemporal hemianopsia. Two years ago, he underwent radical right nephrectomy for a clear cell RCC (ccRCC). The biological tests showed pan-hypopituitarism and diabetes insipidus...
January 3, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28040092/global-access-to-radiotherapy-in-low-and-middle-income-countries
#12
M Abdel-Wahab, E Fidarova, A Polo
Over the last 60 years, the International Atomic Energy Agency (IAEA) has been working to introduce, expand and improve radiotherapy services, working with partners such as the World Health Organization (WHO) to improve cancer diagnosis, treatment, care and control through collective action in low- and middle-income countries (LMICs). The Lancet Oncology Commission on radiotherapy published a report that defined five calls for action to expand global access to radiotherapy, drawing on the previous work of the Global Taskforce on Radiotherapy for Cancer Control...
February 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28034465/locally-advanced-vulva-cancer-a-single-centre-review-of-anovulvectomy-and-a-systematic-review-of-surgical-chemotherapy-and-radiotherapy-alternatives-is-an-international-collaborative-rct-destined-for-the-too-difficult-to-do-box
#13
REVIEW
Rachel Louise O'Donnell, Leen Verleye, Nithya Ratnavelu, Khadra Galaal, Ann Fisher, Raj Naik
INTRODUCTION: Treatment of locally advanced vulva cancer (LAVC) remains challenging. Due to the lack of randomised trials many questions regarding the indications for different treatment options and their efficacy remain unanswered. METHODS: In this retrospective study we provide the largest published series of LAVC patients treated with anovulvectomy, reporting oncological outcomes and morbidity. Additionally, a systematic literature review was performed for all treatment options 1946-2015...
December 26, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/28030806/a-phase-1-dose-escalation-study-of-the-oral-histone-deacetylase-inhibitor-abexinostat-in-combination-with-standard-hypofractionated-radiotherapy-in-advanced-solid-tumors
#14
Eric Deutsch, Elizabeth Cohen-Jonathan Moyal, Vanesa Gregorc, Paolo Andrea Zucali, Jean Menard, Jean-Charles Soria, Ioana Kloos, Jeff Hsu, Ying Luan, Emily Liu, Remus Vezan, Thorsten Graef, Sofia Rivera
Current treatments for advanced solid tumors tend to be only palliative. Although radiotherapy is administered with a curative intent, radioresistance and dose-limiting toxicities pose limitations to treatment. Abexinostat, an oral pan-histone deacetylase inhibitor, demonstrated enhanced sensitivity to radiation in various solid tumor cell lines. We conducted an exploratory, phase 1, dose-escalation study of abexinostat in combination with standard hypofractionated radiotherapy in patients with advanced solid tumors treated in a palliative setting...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28024985/adverse-events-of-self-expandable-esophageal-metallic-stents-in-patients-with-long-term-survival-from-advanced-malignant-disease
#15
Vitor Sousa Medeiros, Bruno Costa Martins, Luciano Lenz, Maria Sylvia Ierardi Ribeiro, Gustavo Andrade de Paulo, Marcelo Simas Lima, Adriana Vaz Safatle-Ribeiro, Fabio Shighuehissa Kawaguti, Caterina Pennacchi, Sebastian N Geiger, Victor R Bastos, Ulysses Ribeiro-Junior, Rubens A Sallum, Fauze Maluf-Filho
BACKGROUND AND AIMS: Self-expandable metallic stents (SEMSs) are considered the best palliative treatment of dysphagia for patients with advanced esophageal cancer. Adverse events (AEs) are a major concern, especially in patients with better prognosis and longer survival. The present study aimed to evaluate the AEs of patients who survived longer than 6 months with esophageal stents in place. METHODS: This is a retrospective analysis of a prospectively collected database including all patients submitted to esophageal stent placement for the palliation of malignant diseases during the period from February 2009 to February 2014 at a tertiary-care academic center, who remained with the stent longer than 6 months...
December 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28018457/relapsed-wilms-tumor-with-multiple-brain-metastasis
#16
Akın Akakın, Baran Yılmaz, Murat Şakir Ekşi, Özlem Yapıcıer, Türker Kılıç
Wilms' tumor is the most common malignant renal tumor in childhood. The brain metastasis of a Wilms' tumor with anaplastic histopathology is rare. We present the case of an 8-year-old girl with Wilms' tumor, who presented with multiple brain metastases 5 years after her primary diagnosis. The brain masses were diagnosed after a generalized tonic-clonic seizure attack. The big solid mass in the cerebellum was resected, and whole-brain radiotherapy was performed, after which, she succumbed to her disease. In the case of clinical suspicion, cranial surveillance should be included in the routine clinical work-up for Wilms' tumor...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28011492/survival-following-palliative-external-beam-radiotherapy-of-locally-advanced-and-metastatic-liver-cancer
#17
Dirk Rades, Louisa Bolm, Steven E Schild, Tobias Bartscht
AIM: The goal of this study was to identify prognostic factors of survival in patients receiving palliative external-beam radiotherapy (EBRT) for advanced liver cancer. PATIENTS AND METHODS: Seventeen patients irradiated for advanced liver cancer were retrospectively evaluated. Fourteen patients had metastatic disease, three had locally advanced disease. Six variables were investigated for survival: age at EBRT, time from liver cancer diagnosis to EBRT, number of involved metastatic sites, gender, Eastern Cooperative Oncology Group (ECOG) performance score, radiation dose...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/28007410/clinical-impact-of-frequent-surveillance-imaging-in-the-first-year-following-chemoradiation-for-locally-advanced-non-small-cell-lung-cancer
#18
Quoc-Anh Ho, Nima K Harandi, Megan E Daly
OBJECTIVE: Uncertainty exists regarding the optimal surveillance imaging schedule following definitive chemoradiation (CRT) for locally advanced non-small-cell lung cancer (LA-NSCLC) with regards to both frequency and modality. We sought to document the clinical impact of frequent (at least every 4 months) surveillance imaging. MATERIALS AND METHODS: The records of all patients treated with CRT for stage IIIA/IIIB NSCLC between August 1999 and April 2014 were reviewed...
November 21, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27992502/what-is-the-value-of-surgical-intervention-for-sacral-metastases
#19
Zhiye Du, Wei Guo, Rongli Yang, Xiaodong Tang, Tao Ji, Dasen Li
OBJECTIVE: To investigate the impact of surgery on local control and quality of life for patients with sacral metastases and to determine whether the complications of surgery were acceptable. METHODS: Curettage for metastatic lesions of the sacrum was performed in 154 patients with obvious sacral nerve compression symptoms between July 1997 and July 2014. Potential risk factors were evaluated in univariate analysis for associations with local control; multivariate conditional logistic regression was used to identify the combined effects...
2016: PloS One
https://www.readbyqxmd.com/read/27991731/novel-treatment-concepts-in-hodgkin-lymphoma
#20
REVIEW
I Glimelius, A Diepstra
Treatment of classical Hodgkin's lymphoma (HL) has been a success story, with cure of localized disease with radiotherapy in the 1930s, cure of advanced stages with combination chemotherapy with/without radiotherapy in the mid-1960s and continuous improvements since then. Nonetheless, at present approximately 2% of patients with classical HL are primarily refractory to conventional therapy with only 50% becoming long-term survivors. Another 13% of patients relapse, with only 60% being alive 10 years postrecurrence (as exemplified in this review in a Swedish cohort of 18- to 65-year-old patients diagnosed during the period 1992-2009)...
December 19, 2016: Journal of Internal Medicine
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