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https://www.readbyqxmd.com/read/29453424/genetic-control-and-evolutionary-potential-of-a-constitutive-resistance-mechanism-against-the-spruce-budworm-choristoneura-fumiferana-in-white-spruce-picea-glauca
#1
Claudia Méndez-Espinoza, Geneviève J Parent, Patrick Lenz, André Rainville, Laurence Tremblay, Greg Adams, Andrew McCartney, Éric Bauce, John MacKay
Insect herbivory may drive evolution by selecting for trees with heritable resistance against defoliation. The spruce budworm (Choristoneura fumiferana, SBW) is a highly damaging forest insect pest that can affect population structure of white spruce (Picea glauca) in North America. Resistance against SBW was recently described in white spruce and was linked to three constitutive resistance biomarkers: the phenolic compounds piceol and pungenol, and expression of a beta-glucosidase encoding gene (Pgβglu-1)...
February 17, 2018: Heredity
https://www.readbyqxmd.com/read/29433578/resistant-hypertension-on-treatment-reshypot-sequential-nephron-blockade-compared-to-dual-blockade-of-the-renin-angiotensin-aldosterone-system-plus-bisoprolol-in-the-treatment-of-resistant-arterial-hypertension-study-protocol-for-a-randomized-controlled-trial
#2
Elizabeth do Espirito Santo Cestário, Letícia Aparecida Barufi Fernandes, Luiz Tadeu Giollo-Júnior, Jéssica Rodrigues Roma Uyemura, Camila Suemi Sato Matarucco, Manoel Idelfonso Paz Landim, Luciana Neves Cosenso-Martin, Lúcia Helena Bonalume Tácito, Heitor Moreno, José Fernando Vilela-Martin, Juan Carlos Yugar-Toledo
BACKGROUND: Resistant hypertension is characterized when the blood pressure (BP) remains above the recommended goal after taking three antihypertensive drugs with synergistic actions at their maximum recommended tolerated doses, preferably including a diuretic. Identifying the contribution of intravascular volume and serum renin in maintaining BP levels could help tailor more effective hypertension treatment, whether acting on the control of intravascular volume or sodium balance, or acting on the effects of the renin-angiotensin-aldosterone system (RAAS) on the kidney...
February 12, 2018: Trials
https://www.readbyqxmd.com/read/29432452/a-conserved-eph-family-receptor-binding-motif-on-the-gh-gl-complex-of-kaposi-s-sarcoma-associated-herpesvirus-and-rhesus-monkey-rhadinovirus
#3
Anna K Großkopf, Armin Ensser, Frank Neipel, Doris Jungnickl, Sarah Schlagowski, Ronald C Desrosiers, Alexander S Hahn
Kaposi's sarcoma-associated herpesvirus (KSHV) is a human oncogenic virus associated with Kaposi's sarcoma and two B-cell malignancies. The rhesus monkey rhadinovirus (RRV) is a virus of nonhuman primates that is closely related to KSHV. Eph family receptor tyrosine kinases (Ephs) are cellular receptors for the gH/gL glycoprotein complexes of both KSHV and RRV. Through sequence analysis and mutational screens, we identified conserved residues in the N-terminal domain of KSHV and RRV glycoprotein H that are critical for Eph-binding in vitro...
February 12, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29422055/calcineurin-a-beta-deficiency-ameliorates-hfd-induced-hypothalamic-astrocytosis-in-mice
#4
Katrin Pfuhlmann, Sonja C Schriever, Beata Legutko, Peter Baumann, Luke Harrison, Dhiraj G Kabra, Emily Violette Baumgart, Matthias H Tschöp, Cristina Garcia-Caceres, Paul T Pfluger
ᅟ: Astrocytosis is a reactive process involving cellular, molecular, and functional changes to facilitate neuronal survival, myelin preservation, blood brain barrier function and protective glial scar formation upon brain insult. The overall pro- or anti-inflammatory impact of reactive astrocytes appears to be driven in a context- and disease-driven manner by modulation of astrocytic Ca2+ homeostasis and activation of Ca2+/calmodulin-activated serine/threonine phosphatase calcineurin. Here, we aimed to assess whether calcineurin is dispensable for astrocytosis in the hypothalamus driven by prolonged high fat diet (HFD) feeding...
February 8, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29415255/validation-of-the-united-registries-for-clinical-assessment-and-research-ur-care-a-european-online-registry-for-clinical-care-and-research-in-inflammatory-bowel-disease
#5
Johan Burisch, Javier P Gisbert, Britta Siegmund, Dominik Bettenworth, Sandra Bohn Thomsen, Isabelle Cleynen, Anneline Cremer, Nik John Sheng Ding, Federica Furfaro, Michail Galanopoulos, Philip Christian Grunert, Jurij Hanzel, Tamara Knezevic Ivanovski, Eduards Krustins, Nurulamin Noor, Neil O'Morain, Iago Rodríguez-Lago, Michael Scharl, Julia Tua, Mathieu Uzzan, Nuha Ali Yassin, Filip Baert, Ebbe Langholz
Background: The "United Registries for Clinical Assessment and Research" (UR-CARE) database is an initiative of the European Crohn's and Colitis Organisation (ECCO) to facilitate daily patient care and research studies in inflammatory bowel disease (IBD). Herein, we sought to validate the database by using fictional case histories of patients with IBD that were to be entered by observers of varying experience in IBD. Methods: A total of 19 observers entered 5 patient case histories into the database...
February 3, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29407091/estradiol-protection-against-toxic-effects-of-catecholamine-on-electrical-properties-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#6
Ibrahim El-Battrawy, Zhihan Zhao, Huan Lan, Jan-Dierk Schünemann, Katherine Sattler, Fanis Buljubasic, Bence Patocskai, Xin Li, Gökhan Yücel, Siegfried Lang, Daniel Nowak, Lukas Cyganek, Karen Bieback, Jochen Utikal, Wolfram-Hubertus Zimmermann, Ursula Ravens, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou, Ibrahim Akin
BACKGROUND AND PURPOSE: Previous studies revealed that Takotsubo cardiomyopathy (TTC), a transient disorder of ventricular dysfunction affecting predominantly postmenopausal women, is associated with acquired long QT syndrome and arrhythmias, but the exact pathophysiologic mechanism is unknown. Our aim is to investigate the electrophysiological mechanism for QT-prolongation in TTC-patients by using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). METHODS: hiPSC-CMs, which were generated from human skin fibroblasts of three healthy donors, were treated by estradiol (10μM for one week) and a toxic concentration of isoprenaline (Iso, 1mM for 2h)...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29383926/piperacillin-tazobactam-anaphylaxis-a-rare-cause-of-occupational-disease
#7
J Gaspar-Marques, E Finelli, P C Martins, S Prates, P Leiria-Pinto
Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure...
November 20, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29382496/-orbital-cellulitis-complicated-by-subperiosteal-abscess-due-to-streptococcus-pyogenes-infection
#8
José Daniel Ruíz Carrillo, Edwin Vázquez Guerrero, Mónica Cecilia Mercado Uribe
BACKGROUND: Orbital cellulitis is an infectious disease that is very common in pediatric patients, in which severe complications may develop. Etiological agents related to this disease are Haemophilus influenzae B, Staphylococcus aureus, Streptococcus pneumoniae and Moraxella catarrhalis, which correspond to 95% of cases. Moreover, Streptococcus beta hemolytic and anaerobic microorganisms may also be present corresponding to < 5% of the cases. We present an uncommon case of cellulitis complicated by sub-periosteal abscess caused by Streptococcus pyogenes (Group A beta hemolytic streptococcus)...
March 2017: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29374204/a-retrospective-clinical-comparison-of-daptomycin-vs-daptomycin-and-a-beta-lactam-antibiotic-for-treating-vancomycin-resistant-enterococcus-faecium-bloodstream-infections
#9
Yu-Chung Chuang, Pao-Yu Chen, Chi-Ying Lin, Yee-Chun Chen, Jann-Tay Wang, Shan-Chwen Chang
There is limited clinical evidence to support the combination of daptomycin and beta-lactam antibiotics (DAP + BLA) for treatment of vancomycin-resistant enterococci (VRE) bloodstream infections (BSI). We conducted a prospective observational cohort study of VRE-BSI during 2010-2015. The primary endpoint was mortality at the end of treatment. We included 114 patients who received DAP for VRE-BSI. Of these 87 (76.3%) received DAP + BLA. There were no significant differences in mortality between the DAP and DAP + BLA groups on univariable analysis (10/27 vs...
January 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29373090/the-beta-2-adrenergic-receptor-antagonist-timolol-improves-healing-of-combined-burn-and-radiation-wounds
#10
Huguette Albrecht, Hsin-Ya Yang, Maija Kiuru, Saipiroon Maksaereekul, Blythe Durbin-Johnson, Michael S Wong, Thomas R Stevenson, David M Rocke, R Rivkah Isseroff
In a scenario involving a nuclear detonation during war or a terrorist attack, acute radiation exposure combined with thermal and blast effects results in severe skin injury. Although the cutaneous injury in such a scenario may not be lethal, it may lead to inflammation, delayed wound healing and loss of the skin barrier, resulting in an increased risk of infection. In this study, we tested the potential use of timolol, a beta-adrenergic receptor antagonist, to improve epidermal wound closure after combined burn and radiation injury using an ex vivo human skin culture model...
January 26, 2018: Radiation Research
https://www.readbyqxmd.com/read/29369179/targeted-next-generation-sequencing-of-malignant-peripheral-nerve-sheath-tumor-of-the-pterygopalatine-fossa-with-intracranial-metastatic-recurrence
#11
Xinjie Bao, Xiangyi Kong, Chengxian Yang, Huanwen Wu, Wenbin Ma, Renzhi Wang
Malignant peripheral nerve sheath tumor (MPNST) is an uncommon neoplasm that rarely involves the head and neck region. Intracranial MPNSTs unrelated to cranial nerves are highly malignant tumors with poor overall survival, probably because of infiltrating growth into surrounding brain tissue. The pathogenesis of MPNST remains unclear. There are no conclusive explanations for the mechanisms underlying the initiation, progression, and metastasis of MPNST. In this paper, we describe a case of MPNST in the pterygopalatine fossa with intracranial metastatic recurrence and review related literatures...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29365446/elevated-systemic-heme-and-iron-levels-as-risk-factor-for-vascular-dysfunction-and-atherosclerosis-evidence-from-a-beta-thalassemia-cohort-study
#12
Francesca Vinchi, Gregory M Vercellotti, John D Belcher, Richard Sparla, Eitan Fibach, Hala Zreid, Rushdy Rasras, Hussam Ghoti, Martina U Muckenthaler, Eliezer A Rachmilewitz
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29358714/identification-of-disulfiram-as-a-secretase-modulating-compound-with-beneficial-effects-on-alzheimer-s-disease-hallmarks
#13
Sven Reinhardt, Nicolai Stoye, Mathias Luderer, Falk Kiefer, Ulrich Schmitt, Klaus Lieb, Kristina Endres
ADAM10 is a metalloproteinase acting on the amyloid precursor protein (APP) as an alpha-secretase in neurons. Its enzymatic activity results in secretion of a neuroprotective APP cleavage product (sAPP-alpha) and prevents formation of the amyloidogenic A-beta peptides, major hallmarks of Alzheimer's disease (AD). Elevated ADAM10 levels appeared to contribute to attenuation of A-beta-plaque formation and learning and memory deficits in AD mouse models. Therefore, it has been assumed that ADAM10 might represent a valuable target in AD therapy...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352427/preserved-in-vitro-immunoreactivity-in-children-receiving-long-term-immunosuppressive-therapy-due-to-inflammatory-bowel-disease-or-autoimmune-hepatitis
#14
Teresa Schleker, Eva-Maria Jacobsen, Benjamin Mayer, Gudrun Strauss, Klaus-Michael Debatin, Carsten Posovszky
BACKGROUND: Children with inflammatory bowel disease (IBD) or autoimmune hepatitis (AIH) are at risk for severe infections. This is partially a result of their chronic disease condition but, moreover, a side effect of their immunosuppressive therapy. Currently, vaccinations with live vaccines are regarded as contraindicated under immunosuppressive therapy, mainly because of concerns about side effects and a lack of data showing an adequate immune reaction. As there is no systematic study on the individual immunoreactivity under immunosuppressive therapy in this patient group, we analyzed the lymphocyte subgroups and immunoreactivity of lymphocytes in children with IBD or AIH with and without immunosuppressive therapy in vitro...
January 19, 2018: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/29351278/analysis-of-the-tonsillar-microbiome-in-young-adults-with-sore-throat-reveals-a-high-relative-abundance-of-fusobacterium-necrophorum-with-low-diversity
#15
T Prescott Atkinson, Robert M Centor, Li Xiao, Fuchenchu Wang, Xiangqin Cui, William Van Der Pol, Casey D Morrow, Amy E Ratliff, Donna M Crabb, Arthur H Totten, Carlos A Estrada, Michael B Faircloth, Ken B Waites
Fusobacterium necrophorum (Fn), a gram-negative anaerobe, is increasingly implicated as an etiologic agent in older adolescents and young adults with sore throat. Inadequately treated Fn pharyngitis may result in suppurative complications such as peritonsillar abscess and Lemierre's syndrome. Data from the literature suggest that the incidence of life-threating complications in these age groups from Fn pharyngitis (Lemierre's syndrome) in the United States exceeds those associated with group A beta-hemolytic streptococcal (GAS) pharyngitis (acute rheumatic fever)...
2018: PloS One
https://www.readbyqxmd.com/read/29350254/sacubitril-valsartan-for-heart-failure-with-reduced-left-ventricular-ejection-fraction-a%C3%A2-retrospective-cohort-study
#16
R De Vecchis, C Ariano, G Di Biase, M Noutsias
BACKGROUND: The combination drug sacubitril/valsartan was reported to be superior to enalapril in reducing all-cause death, cardiovascular mortality, and heart failure (HF) hospitalizations in patients with cardiac insufficiency and reduced left ventricular ejection fraction (HFREF) with NYHA class II-IV. METHODS: Our retrospective cohort study aimed to assess the effects of sacubitril/valsartan in addition to a beta-blocker and mineral receptor antagonist (MRA) in a group of HFREF patients with NYHA class II-III HF vs...
January 19, 2018: Herz
https://www.readbyqxmd.com/read/29345054/isoflurane-anesthesia-in-aged-mice-and-effects-of-a1-adenosine-receptors-on-cognitive-impairment
#17
Chun-Long Zuo, Chun-Man Wang, Jin Liu, Ting Shen, Jiang-Ping Zhou, Xin-Rui Hao, Yi-Zhao Pan, Hua-Cheng Liu, Qing-Quan Lian, Han Lin
AIMS: Isoflurane may not only accelerate the process of Alzheimer's disease (AD), but increase the risk of incidence of postoperative cognitive dysfunction (POCD). However, the underlying mechanisms remain unknown. This study was designed to investigate whether isoflurane contributed to the POCD occurrence through A1 adenosine receptor (A1AR) in aged mice. METHODS: We assessed cognitive function of mice with Morris water maze (MWM) and then measured expression level of two AD biomarkers (P-tau and Aβ) and a subtype of the NMDA receptor (NR2B) in aged wild-type (WT) and homozygous A1 adenosine receptor (A1AR) knockout (KO) mice at baseline and after they were exposed to isoflurane (1...
January 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29344787/a-novel-fully-covered-double-bump-stent-for-staple-line-leaks-after-bariatric-surgery-a-retrospective-analysis
#18
Thomas C C Boerlage, Gerardus P M Houben, Marcel J M Groenen, Klaas van der Linde, Arnold W J M van de Laar, Marloes Emous, Paul Fockens, Rogier P Voermans
BACKGROUND: Staple line leakage after bariatric surgery can be treated by endoscopic placement of a self-expandable stent. The success rate of stent placement is generally high, but migration is a frequent adverse event that hampers successful treatment. The Niti-S Beta stent is a fully covered double-bump stent that was specifically designed to prevent migration. This study aimed to evaluate the effectiveness and adverse event rate of the Niti-S Beta stent. METHODS: A retrospective study was performed in three high-volume bariatric centers...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29338212/catalytic-dehydrogenative-stannylation-of-c-sp-h-bonds-involving-cooperative-sn-h-bond-activation-of-hydrostannanes
#19
Francis Forster, Victoria M Rendón López, Martin Oestreich
The catalytic generation of a stannylium-ion-like tin electrophile by heterolytic cleavage of the Sn-H bond in hydrostannes at the Ru-S bond of Ohki-Tatsumi complexes is reported. Reacting these activated hydrostannanes with terminal acetylenes does not lead to hydrostannylation of the C-C triple bond but to dehydrogenative stannylation of the alkyne terminus. The scope of this rare direct C(sp)-H bond stannylation with hydrostannanes is broad, and a mechanism involving a beta-tin-stabilized vinyl cation having a bridged structure is presented...
January 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29337862/therapeutic-management-of-pseudomonas-aeruginosa-bloodstream-infection-non-susceptible-to-carbapenems-but-susceptible-to-old-cephalosporins-and-or-to-penicillins
#20
Ronit Zaidenstein, Asaf Miller, Ruthy Tal-Jasper, Hadas Ofer-Friedman, Menachem Sklarz, David E Katz, Tsillia Lazarovitch, Paul R Lephart, Bethlehem Mengesha, Oran Tzuman, Mor Dadon, Chen Daniel, Jacob Moran-Gilad, Dror Marchaim
It is unknown as to whether other beta-lactams can be used for bloodstream infections (BSI) resulting from Pseudomonas aeruginosa (PA) which are non-susceptible to one or more carbapenem. We conducted a retrospective cohort study at the Assaf Harofeh Medical Center (AHMC) from January 2010 to August 2014. Adult patients with PA-BSI non-susceptible to a group 2 carbapenem but susceptible to ceftazidime or piperacillin (with or without tazobactam), were enrolled. We compared the outcomes of patients who received an appropriate beta-lactam antibiotic ("cases") to those who received an appropriate non-beta-lactam antibiotic ("controls")...
January 16, 2018: Microorganisms
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