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https://www.readbyqxmd.com/read/28107445/beta-glucans-supplementation-associates-with-reduction-in-p-cresyl-sulfate-levels-and-improved-endothelial-vascular-reactivity-in-healthy-individuals
#1
Carmela Cosola, Maria De Angelis, Maria Teresa Rocchetti, Eustacchio Montemurno, Valentina Maranzano, Giuseppe Dalfino, Carlo Manno, Annapaola Zito, Michele Gesualdo, Marco Matteo Ciccone, Marco Gobbetti, Loreto Gesualdo
BACKGROUND: Oat and barley beta-glucans are prebiotic fibers known for their cholesterol-lowering activity, but their action on the human gut microbiota metabolism is still under research. Although the induction of short-chain fatty acids (SCFA) following their ingestion has previously been reported, no study has investigated their effects on proteolytic uremic toxins p-cresyl sulfate (pCS) and indoxyl sulfate (IS) levels, while others have failed to demonstrate an effect on the endothelial function measured through flow-mediated dilation (FMD)...
2017: PloS One
https://www.readbyqxmd.com/read/28095924/sonolysis-in-prevention-of-brain-infarctions-during-internal-carotid-endarterectomy-sonobirdie-trial-study-protocol-for-a-randomized-controlled-trial
#2
Tomáš Hrbáč, David Netuka, Vladimír Beneš, Vladimír Nosáľ, Petra Kešnerová, Aleš Tomek, Táňa Fadrná, Vladimír Beneš, Jiří Fiedler, Vladimír Přibáň, Miroslav Brozman, Kateřina Langová, Roman Herzig, David Školoudík
BACKGROUND: Carotid endarterectomy (CEA) is a beneficial procedure for selected patients with an internal carotid artery (ICA) stenosis. Surgical risk of CEA varies from between 2 and 15%. The aim of the study is to demonstrate the safety and effectiveness of sonolysis (continual transcranial Doppler monitoring, TCD) using a 2-MHz diagnostic probe with maximal diagnostic energy on the reduction of the incidence of stroke, transient ischemic attack (TIA) and brain infarction detected using magnetic resonance imaging (MRI) by the activation of the endogenous fibrinolytic system during CEA...
January 17, 2017: Trials
https://www.readbyqxmd.com/read/28081323/acute-exudative-tonsillitis-in-adults-the-use-of-the-centor-scoreand-some-laboratory-tests
#3
Yavuz Furuncuoğlu, Filiz Sağlam, Ahmet Kutluhan
BACKGROUND/AIM: The aim of our study was to determine the usefulness of the Centor score and some basic laboratory tests (complete blood count and C-reactive protein) for the differential diagnosis of exudative tonsillitis due to Group A β-hemolytic streptococcus (GABHS) or due to non-GABHS agents. MATERIALS AND METHODS: The data of clinical and laboratory characteristics of the patients diagnosed with exudative tonsillitis were collected and statistically compared between those having positive GABHS throat culture result and those who were negative for any bacterial agent...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28068154/adapting-a-computer-delivered-brief-alcohol-intervention-for-veterans-with-hepatitis-c
#4
Michael A Cucciare, Andrea L Jamison, Ann S Combs, Gauri Joshi, Ramsey C Cheung, Catherine Rongey, Joe Huggins, Keith Humphreys
OBJECTIVE: This study adapted an existing computer-delivered brief alcohol intervention (cBAI) for use in Veterans with the hepatitis C virus (HCV) and examined its acceptability and feasibility in this patient population. METHODS: A four-stage model consisting of initial pilot testing, qualitative interviews with key stakeholders, development of a beta version of the cBAI, and usability testing was used to achieve the study objectives. RESULTS: In-depth interviews gathered feedback for modifying the cBAI, including adding HCV-related content such as the health effects of alcohol on liver functioning, immune system functioning, and management of HCV, a preference for concepts to be displayed through "newer looking" graphics, and limiting the use of text to convey key concepts...
January 9, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/28062388/netf-producing-clostridium-perfringens-clonality-and-plasmid-pathogenicity-loci-analysis
#5
Iman Mehdizadeh Gohari, Andrew M Kropinski, Scott J Weese, Ashley E Whitehead, Valeria R Parreira, Patrick Boerlin, John F Prescott
Clostridium perfringens is an important cause of foal necrotizing enteritis and canine acute hemorrhagic diarrhea. A major virulence determinant of the strains associated with these diseases appears to be a beta-sheet pore-forming toxin, NetF, encoded within a pathogenicity locus (NetF locus) on a large tcp-conjugative plasmid. Strains producing NetF also produce the putative toxin NetE, encoded within the same pathogenicity locus, as well as CPE enterotoxin and CPB2 on a second plasmid, and sometimes the putative toxin NetG within a pathogenicity locus (NetG locus) on another separate large conjugative plasmid...
January 3, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28058556/surgical-treatment-of-malignant-pheochromocytoma-and-paraganglioma-retrospective-case-series
#6
Veljko Strajina, Benzon M Dy, David R Farley, Melanie L Richards, Travis J McKenzie, Keith C Bible, Florencia G Que, David M Nagorney, William F Young, Geoffrey B Thompson
INTRODUCTION: Pheochromocytoma and paraganglioma (PPGL) are rare neoplasms; about 10% are malignant. Literature regarding possible benefit from resection is extremely limited. METHODS: A 20 year review of all patients undergoing surgery for malignant PPGL at the Mayo Clinic Rochester Campus between 1994 and June 2014 was performed. RESULTS: We identified 34 patients undergoing surgery for malignant PPGL. Median follow up was 6 and 5 years survival was 90% (median 11 years)...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28057444/redefining-beta-blocker-use-in-hypertension-selecting-the-right-beta-blocker-and-the-right-patient
#7
REVIEW
Samuel J Mann
Randomized controlled trials have concluded that the cardiovascular outcome of first-step treatment of hypertension with traditional vasoconstricting beta-blockers is inferior to treatment with other antihypertensive drug classes. Beta-blocker use is also associated with undesirable side effects. Consequently, some recent guidelines consider beta-blockers an inferior option for first-step treatment of hypertension. Despite this, beta-blockers are still widely prescribed, and likely overused, in the management of hypertension...
December 5, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28046169/effect-of-shade-on-animal-welfare-growth-performance-and-carcass-characteristics-in-large-pens-of-beef-cattle-fed-a-beta-agonist-in-a-commercial-feedlot
#8
J A Hagenmaier, C D Reinhardt, S J Bartle, D U Thomson
Feedlot cattle ( = 1,395; BW = 568 ± 43 kg) were used to evaluate the effects of shade on animal welfare, growth performance, and carcass quality during the summer of 2013 in a Kansas commercial feedlot. Seven lots of predominately black steers and heifers (4 and 3, respectively) visually determined to be approaching the final mo on feed were identified, randomly gate-sorted, and allocated to pens located across the feed alley from each other to receive 1 of 2 treatments: 1) Shade (mean shade area = 1.5 m/ animal) or 2) No shade...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28043664/galectin-3-is-an-independent-predictor-of-survival-in-systemic-sclerosis
#9
Réka Faludi, Gabriella Nagy, Margit Tőkés-Füzesi, Krisztina Kovács, László Czirják, András Komócsi
BACKGROUND: Galectin-3 is a beta-galactoside-binding lectin that may be related to tissue sclerosis or aberrant activation of angiogenesis in systemic sclerosis (SSc). The aim of our study was to determine the associations between galectin-3 levels and patient characteristics, as well as to investigate the long term prognostic value of galectin-3 in a large cohort of SSc patients. METHODS: 152 patients with SSc (55±11years, 138 female) were included in our follow-up study...
December 28, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28036305/role-of-the-density-density-effect-and-mean-excitation-energy-in-solid-state-detectors-for-small-photon-fields
#10
Pedro Andreo, Hamza Benmakhlouf
A number of recent publications on small photon beam dosimetry aim at contributing to the understanding of the response of solid-state detectors in small fields. Some of them assign the difference in response to the mass density, or to the electron density, of the sensitive detector material relative to that of water. This work analyses the role of the mass and electron density, density effect and mean excitation energy of some detector materials in a 6~MV photon beam of 5~mm radius, its rationale being that the response of a detector depends critically on the stopping-power ratio detector-to-water...
December 30, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28032956/efficacy-and-safety-of-propranolol-for-epistaxis-in-hereditary-hemorrhagic-telangiectasia-hht-retrospective-then-prospective-study-in-a-total-of-21-patients
#11
A Contis, N Gensous, J F Viallard, C Goizet, C Léauté-Labrèze, P Duffau
Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder of angiogenesis associated with disabling epistaxis. Propranolol, a beta-blocker, exerts anti-angiogenic properties. In the retrospective study, nine of ten HHT patients receiving propranolol significantly improved their Epistaxis Severity Score. In the prospective study, after three months of propranolol treatment, the median duration of epistaxis per month significantly decreased as did the number of epistaxis episodes per month in 11 HHT patients...
December 29, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28028645/comparison-of-a-calcium-phosphate-bone-substitute-with-recombinant-human-bone-morphogenetic-protein-2-a-prospective-study-of-fusion-rates-clinical-outcomes-and-complications-with-24-month-follow-up
#12
Rhiannon M Parker, Gregory M Malham
PURPOSE: Recombinant human bone morphogenetic protein-2 (rhBMP-2) generally provides high rates of clinical improvement and fusion. However, rhBMP-2 has been associated with adverse effects. Recently, a beta tricalcium phosphate (β-TCP) bone substitute has been developed. The aim of this study was to determine the fusion rates and clinical outcomes of patients treated with β-TCP compared to rhBMP-2. METHODS: One hundred and thirty-five consecutive patients who underwent lateral lumbar interbody fusion with β-TCP (n = 25) or rhBMP-2 (n = 110) in the interbody cage were included in the study...
December 27, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28018371/thermal-time-model-for-egyptian-broomrape-phelipanche-aegyptiaca-parasitism-dynamics-in-carrot-daucus-carota-l-field-validation
#13
Amnon Cochavi, Baruch Rubin, Guy Achdari, Hanan Eizenberg
Carrot, a highly profitable crop in Israel, is severely damaged by Phelipanche aegyptiaca parasitism. Herbicides can effectively control the parasite and prevent damage, but for optimal results, knowledge about the soil-subsurface phenological stage of the parasite is essential. Parasitism dynamics models have been successfully developed for the parasites P. aegyptiaca, Orobanche cumana, and Orobanche minor in the summer crops, tomato, sunflower, and red clover, respectively. However, these models, which are based on a linear relationship between thermal time and the parasitism dynamics, may not necessarily be directly applicable to the P...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28006098/regiochemically-controlled-synthesis-of-a-%C3%AE-4-%C3%AE-70-fullerene-bis-adduct
#14
Maira R Cerón, Edison Castro, Venkata S Pavan K Neti, Paul W Dunk, Luis A Echegoyen
A β-4-β' C70 bis-adduct regioisomer and an uncommon mono-adduct β-malonate C70 derivative were synthesized by using a Diels-Alder cycloaddition followed by an addition-elimination of bromo-ethylmalonate and a retro-Diels-Alder cycloaddition reaction. We also report the regioselective synthesis and spectroscopic characterization of Cs-symmetric tris- and C2v-symmetric tetra-adducts of C70, which are the precursors of the mono- and bis-adduct final products.
January 9, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28004885/novel-thermostable-antibiotic-resistance-enzymes-from-the-atlantis-ii-deep-red-sea-brine-pool
#15
Ali H A Elbehery, David J Leak, Rania Siam
The advent of metagenomics has greatly facilitated the discovery of enzymes with useful biochemical characteristics for industrial and biomedical applications, from environmental niches. In this study, we used sequence-based metagenomics to identify two antibiotic resistance enzymes from the secluded, lower convective layer of Atlantis II Deep Red Sea brine pool (68°C, ~2200 m depth and 250‰ salinity). We assembled > 4 000 000 metagenomic reads, producing 43 555 contigs. Open reading frames (ORFs) called from these contigs were aligned to polypeptides from the Comprehensive Antibiotic Resistance Database using BLASTX...
December 22, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27997710/the-presence-of-non-native-helical-structure-in-the-unfolding-of-a-beta-sheet-protein-mpt63
#16
Amrita Kundu, Sangeeta Kundu, Krishnananda Chattopadhyay
MPT63, a major secreted protein from Mycobacterium tuberculosis, has been shown to have immunogenic properties and has been implicated in virulence. MPT63 is a β-sandwich protein containing 11 β strands and a very short stretch of 310 helix. The detailed experimental and computational study reported here investigates the equilibrium unfolding transition of MPT63. It is shown that in spite of being a complete β-sheet protein, MPT63 has a strong propensity towards helix structures in its early intermediates...
December 20, 2016: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/27981538/diagnosis-and-treatment-of-acute-pharyngitis-tonsillitis-a-preliminary-observational-study-in-general-medicine
#17
F Di Muzio, M Barucco, F Guerriero
OBJECTIVE: According to recent observations, the insufficiently targeted use of antibiotics is creating increasingly resistant bacterial strains. In this context, it seems increasingly clear the need to resort to extreme and prudent rationalization of antibiotic therapy, especially by the physicians working in primary care units. In clinical practice, actually the general practitioner often treats multiple diseases without having the proper equipment. In particular, the use of a dedicated, easy to use diagnostic test would be one more weapon for the correct diagnosis and treatment of acute pharyngo-tonsillitis...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27951636/adjuvant-activity-enhanced-by-cross-linked-cpg-oligonucleotides-in-%C3%AE-glucan-nanogel-and-its-antitumor-effect
#18
Noriko Miyamoto, Shinichi Mochizuki, Shota Fujii, Kenta Yoshida, Kazuo Sakurai
Cancer vaccine has the ability to directly eradicate tumor cells by creating and activating cytotoxic T lymphocytes (CTLs). To achieve efficient CTL activity and to induce Th1 responses, it is essential to administer an appropriate adjuvant as well as an antigen. CpG-ODN is known as a ligand of Toll-like receptor 9 (TLR9) and strongly induces Th1 responses. In our previous study, we developed a CpG-ODN delivery system by use of the formation of complexes between ODN and a β-glucan SPG, denoted as CpG/SPG, and demonstrated that CpG/SPG induces high Th1 responses...
January 13, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27942930/phase-ii-trial-of-capecitabine-plus-modified-cisplatin-mxp-as-first-line-therapy-in-japanese-patients-with-metastatic-gastric-cancer-kscc1104
#19
Hironaga Satake, Masaaki Iwatsuki, Yoshikazu Uenosono, Takeshi Shiraishi, Hiroaki Tanioka, Hiroshi Saeki, Keishi Sugimachi, Dai Kitagawa, Mototsugu Shimokawa, Eiji Oki, Yasunori Emi, Yoshihiro Kakeji, Akihito Tsuji, Yoshito Akagi, Shoji Natsugoe, Hideo Baba, Yoshihiko Maehara
PURPOSE: Capecitabine plus cisplatin (XP) is a standard therapy for metastatic gastric cancer (mGC). However, while results from previous phase III trials suggested that the cisplatin dosage should be reduced in Japanese patients, no clinical data exist to support this. Here, we conducted a multicenter study to evaluate the efficacy and safety of modified XP (mXP) in Japanese patients with mGC. METHODS: Patients with previously untreated mGC received mXP (cisplatin 60 mg/m(2) on day 1 plus capecitabine 1000 mg/m(2) twice daily on days 1-14) every 3 weeks...
December 10, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27941847/association-between-vitamin-a-retinol-and-carotenoid-intake-and-pancreatic-cancer-risk-evidence-from-epidemiologic-studies
#20
Xiaoyi Huang, Yisha Gao, Xiaosong Zhi, Na Ta, Hui Jiang, Jianming Zheng
Pancreatic cancer is a devastating disease with poor prognosis. The association between vitamin A, retinol and carotenoid intake and the risk of pancreatic cancer occurrence remains controversial, and therefore it is necessary to make a meta-analysis to clarify the association between vitamin A, retinol and carotenoid intake and pancreatic cancer risk. In the present study, PubMed and EMBASE databases were used to identify qualified studies. The association between dietary vitamin A, retinol and carotenoids was estimated by pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs)...
December 12, 2016: Scientific Reports
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