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https://www.readbyqxmd.com/read/28332574/natural-variation-in-ctb4a-enhances-rice-adaptation-to-cold-habitats
#1
Zhanying Zhang, Jinjie Li, Yinghua Pan, Jilong Li, Lei Zhou, Hongli Shi, Yawen Zeng, Haifeng Guo, Shuming Yang, Weiwei Zheng, Jianping Yu, Xingming Sun, Gangling Li, Yanglin Ding, Liang Ma, Shiquan Shen, Luyuan Dai, Hongliang Zhang, Shuhua Yang, Yan Guo, Zichao Li
Low temperature is a major factor limiting rice productivity and geographical distribution. Improved cold tolerance and expanded cultivation to high-altitude or high-latitude regions would help meet growing rice demand. Here we explored a QTL for cold tolerance and cloned the gene, CTB4a (cold tolerance at booting stage), encoding a conserved leucine-rich repeat receptor-like kinase. We show that different CTB4a alleles confer distinct levels of cold tolerance and selection for variation in the CTB4a promoter region has occurred on the basis of environmental temperature...
March 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28330464/spectral-temporal-eeg-dynamics-of-speech-discrimination-processing-in-infants-during-sleep
#2
Phillip M Gilley, Kristin Uhler, Kaylee Watson, Christine Yoshinaga-Itano
BACKGROUND: Oddball paradigms are frequently used to study auditory discrimination by comparing event-related potential (ERP) responses from a standard, high probability sound and to a deviant, low probability sound. Previous research has established that such paradigms, such as the mismatch response or mismatch negativity, are useful for examining auditory processes in young children and infants across various sleep and attention states. The extent to which oddball ERP responses may reflect subtle discrimination effects, such as speech discrimination, is largely unknown, especially in infants that have not yet acquired speech and language...
March 22, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28329670/telomere-length-cutaneous-beta-human-papillomavirus-infection-and-cutaneous-squamous-cell-carcinoma
#3
Shalaka Hampras, Michael Pawlita, Massimo Tommasino, Jong Park, Pearlie Burnette, Neil Fenske, Basil Cherpelis, Dana Rollison
BackgroundCutaneous beta-human papillomavirus (HPV) infection and telomere length have both been associated with cutaneous squamous cell carcinoma (SCC). We examined the interaction between telomere length and beta-HPV in association with SCC.MethodsA subset of SCC cases and controls, enrolled in a previously conducted case-control study (2007-2008) at the University of South Florida and Moffitt Cancer Center, for whom data was available on telomere length and a) beta-HPV serology (135 cases and 201 controls), b) beta-HPV DNA in eyebrow hairs (EB) (130 SCC cases and 195 controls) and c) beta-HPV DNA in SCC tumors (117 cases), were included in the present analyses...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28316142/evolutionary-ecology-of-beta-lactam-gene-clusters-in-animals
#4
Wouter Suring, Karen Meusemann, Alexander Blanke, Janine Mariën, Tim Schol, Valeria Agamennone, Anna Faddeeva-Vakhrusheva, Matty P Berg, Bram Brouwer, Nico M van Straalen, Dick Roelofs
Beta-lactam biosynthesis was thought to occur only in fungi and bacteria, but we recently reported the presence of isopenicillin N synthase in a soil-dwelling animal, Folsomia candida. However, it has remained unclear whether this gene is part of a larger beta-lactam biosynthesis pathway and how widespread the occurrence of penicillin biosynthesis is among animals. Here, we analyzed the distribution of beta-lactam biosynthesis genes throughout the animal kingdom and identified a beta-lactam gene cluster in the genome of F...
March 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28304350/a-multifunctional-bread-rich-in-beta-glucans-and-low-in-starch-improves-metabolic-control-in-type-2-diabetes-a-controlled-trial
#5
Paolo Tessari, Anna Lante
DESIGN: Functional foods may be useful for people with diabetes. The soluble fibers beta glucans can modify starch digestion and improve postprandial glucose response. We analyzed the metabolic effects of a specifically designed 'functional' bread, low in starch, rich in fibers (7 g/100 g), with a beta glucan/starch ratio of (7.6:100, g/g), in people with type 2 diabetes mellitus. Methods: Clinical and metabolic data from two groups of age-, sex- and glycated hemoglobin-matched diabetic subjects, taking either the functional bread or regular white bread, over a roughly six-month observation period, were retrieved...
March 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28300170/cd8-t-cells-specific-for-the-islet-autoantigen-igrp-are-restricted-in-their-t-cell-receptor-chain-usage
#6
Yannick F Fuchs, Anne Eugster, Sevina Dietz, Christian Sebelefsky, Denise Kühn, Carmen Wilhelm, Annett Lindner, Anita Gavrisan, Jan Knoop, Andreas Dahl, Anette-G Ziegler, Ezio Bonifacio
CD8(+) T cells directed against beta cell autoantigens are considered relevant for the pathogenesis of type 1 diabetes. Using single cell T cell receptor sequencing of CD8(+) T cells specific for the IGRP265-273 epitope, we examined whether there was expansion of clonotypes and sharing of T cell receptor chains in autoreactive CD8(+) T cell repertoires. HLA-A*0201 positive type 1 diabetes patients (n = 19) and controls (n = 18) were analysed. TCR α- and β-chain sequences of 418 patient-derived IGRP265-273-multimer(+) CD8(+) T cells representing 48 clonotypes were obtained...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299853/the-effect-of-a-beta-lactamase-inhibitor-peptide-on-bacterial-membrane-structure-and-integrity-a-comparative-study
#7
Begum Alaybeyoglu, Bilge Gedik Uluocak, Berna Sariyar Akbulut, Elif Ozkirimli
Co-administration of beta-lactam antibiotics and beta-lactamase inhibitors has been a favored treatment strategy against beta-lactamase-mediated bacterial antibiotic resistance, but the emergence of beta-lactamases resistant to current inhibitors necessitates the discovery of novel non-beta-lactam inhibitors. Peptides derived from the Ala46-Tyr51 region of the beta-lactamase inhibitor protein are considered as potent inhibitors of beta-lactamase; unfortunately, peptide delivery into the cell limits their potential...
March 16, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28290668/surface-assay-for-specific-detection-of-soluble-amyloid-oligomers-utilizing-pronucleon-peptides-instead-of-antibodies
#8
Evgenia G Matveeva, Jonathan R Moll, Mariam M Khan, Richard B Thompson, Richard O Cliff
Immunoassays such as enzyme-linked immunosorbent assays (ELISAs) are widely used for diagnostics; however, antibodies as detection reagents may be insufficiently selective and have other shortcomings. We present a novel non-antibody-based detection method based on binding target molecules to peptides (used as recognition molecules): a surface assay for A-β oligomers employing a peptide comprising amino acid residues of the human β-amyloid protein (Pronucleon peptide) as the capture agent. For the sake of convenience, we term this the "Pronucleon peptide-linked immunosorbent assay", or PLISA...
March 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28288328/case-control-exploratory-study-of-cerebrospinal-fluid-chemokines-cytokines-and-lymphocyte-subsets-in-childhood-tourette-syndrome-with-positive-streptococcal-markers
#9
Michael R Pranzatelli, Elizabeth D Tate, Tyler J Allison
A longstanding question is whether neuroinflammation is present in children symptomatic for Tourette syndrome (TS) with positive streptococcal serology and throat cultures. The objective was to directly test for it using modern hypothesis-driven approaches. Profiling studies for 14 immune cell types (flow cytometry), 7 chemokines/cytokines (ELISA), oligoclonal bands, and other immunoglobulins were performed in this IRB-approved study of 5 children with TS and streptococcal markers compared to data from 26 non-inflammatory pediatric neurological controls...
March 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28283012/-evaluation-of-mascia-brunelli-rapid-antigen-test-in-the-diagnosis-of-group-a-streptococcal-pharyngitis
#10
Ayşe Barış, Nur Anlıaçık, Mehmet Emin Bulut, Rıdvan Deniz, Elif Yücel, Elif Aktaş
Pharyngitis in most cases is due to viral microorganisms however drug therapy without the detection of etiological agent leads to unnecessary use of antibiotics. On the other hand, when the etiologic agent is group A beta-hemolytic streptococci (GAS) it is important to identify the etiologic agent rapidly which will guide the treatment with appropriate antibiotics. The use of highly sensitive rapid tests will contribute significantly to early diagnosis and appropriate therapy. The aim of this study is to evaluate the efficacy of Mascia Brunelli rapid antigen test for the detection of GAS in throat swab samples...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28283006/-investigation-of-biofilm-formation-properties-of-staphylococcus-isolates
#11
Duygu Nilüfer Öcal, İştar Dolapçı, Zeynep Ceren Karahan, Alper Tekeli
Biofilm production is an important virulence factor which allows staphylococci to adhere to medical devices. The principal component of biofilm is a "polysaccharide intercellular adhesin (PIA)" which is composed of a beta-1,6-N-acetylglucosamine polymer synthesized by an enzyme (N-acetylglucosamine transferase) encoded by the ica operon found on the bacterial chromosome. This operon is composed of four genes (A, B, C, and D), and a transposable element IS256. In this study, we aimed to determine the biofilm production characteristics of invasive/non-invasive staphylococcus isolates and different staphylococcus species...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28268752/design-and-optimization-of-partner-a-parallel-actuated-robotic-trainer-for-neurorehabilitation
#12
Hossein Taheri, Stephen A Goodwin, James A Tigue, Joel C Perry, Eric T Wolbrecht
Robotic devices are a promising and dynamic tool in the realm of post-stroke rehabilitation. Researchers are still investigating how the use of robots affects motor learning and what design characteristics best encourage recovery. We present a parallel-actuated, end-effector robot designed to provide spatial assistance for upper-limb therapy while exhibiting low impedance and high backdrivability. A gradient based optimization was performed to find an optimal design that accounted for force isotropy, mechanical advantage, workspace size, and counter-balancing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266826/cardiovascular-disease-update-care-of-patients-after-coronary-artery-bypass-graft
#13
Craig Barstow, Johnathan D McDivitt
Coronary artery bypass graft (CABG) is a surgical procedure in which a vessel, normally the left internal mammary artery and/or a segment of an excised vein (typically from the leg), is grafted to the coronary arteries to bypass a blockage. CABG has been shown to be superior to percutaneous coronary intervention for patients with complex three vessel disease and left main coronary artery disease. All patients undergoing CABG should receive aspirin preoperatively; they also should receive a beta blocker preoperatively to reduce the likelihood of postsurgical atrial fibrillation...
March 2017: FP Essentials
https://www.readbyqxmd.com/read/28265241/app-a-novel-player-within-the-presynaptic-active-zone-proteome
#14
REVIEW
Jens Weingarten, Melanie Weingarten, Martin Wegner, Walter Volknandt
The amyloid precursor protein (APP) was discovered in the 1980s as the precursor protein of the amyloid A4 peptide. The amyloid A4 peptide, also known as A-beta (Aβ), is the main constituent of senile plaques implicated in Alzheimer's disease (AD). In association with the amyloid deposits, increasing impairments in learning and memory as well as the degeneration of neurons especially in the hippocampus formation are hallmarks of the pathogenesis of AD. Within the last decades much effort has been expended into understanding the pathogenesis of AD...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28264993/going-outside-the-tonb-box-identification-of-novel-fepa-tonb-interactions-in-vivo
#15
Michael G Gresock, Kathleen Postle
In Gram-negative bacteria, the cytoplasmic membrane protein TonB transmits energy derived from protonmotive force to energize transport of important nutrients through TonB-dependent transporters in the outer membrane. Each transporter consists of a beta-barrel domain and a lumen-occluding cork domain containing an essential sequence called the TonB box. To date, the only identified site of transporter-TonB interaction is between the TonB box and residues ∼158-162 of TonB. While the mechanism of ligand transport is a mystery, a current model based on site-directed spin labeling and molecular dynamics simulations is that, following ligand binding, the otherwise-sequestered TonB box extends into the periplasm for recognition by TonB, which mediates transport by pulling or twisting the cork...
March 6, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28263195/toenail-bracing-complicated-with-group-a-beta-haemolytic-streptococcus-infection
#16
Anca Chiriac, Cristina Birsan, Calin Molnar, Simona Stolnicu
No abstract text is available yet for this article.
March 2, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28261264/ferrous-iron-up-regulation-in-fibroblasts-of-patients-with-beta-propeller-protein-associated-neurodegeneration-bpan
#17
Rosaria Ingrassia, Maurizio Memo, Barbara Garavaglia
Mutations in WDR45 gene, coding for a beta-propeller protein, have been found in patients affected by Neurodegeneration with Brain Iron Accumulation, NBIA5 (also known as BPAN). BPAN is a movement disorder with Non Transferrin Bound Iron (NTBI) accumulation in the basal ganglia as common hallmark between NBIA classes (Hayflick et al., 2013). WDR45 has been predicted to have a role in autophagy, while the impairment of iron metabolism in the different NBIA subclasses has not currently been clarified. We found the up-regulation of the ferrous iron transporter (-)IRE/Divalent Metal Transporter1 and down-regulation of Transferrin receptor in the fibroblasts of two BPAN affected patients with splicing mutations 235+1G>A (BPAN1) and 517_519ΔVal 173 (BPAN2)...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28260499/regulatory-role-of-g-protein-coupled-receptors-in-pancreatic-cancer-development-and-progression
#18
Hildegard M Schuller
BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer deaths with incidence rising and a high mortality rate. Smoking, psychological stress, diabetes, pancreatitis and alcohol abuse are known risk factors for pancreatic cancer. OBJECTIVE: Targeting G protein-coupled receptor signaling for the prevention and therapy of pancreatic cancer. METHOD: Review of published literature. RESULTS AND CONCLUSION: All known risk factors for pancreatic cancer cause hyperactive cyclic adenosine monophosphate (cAMP) signaling via cancer stimulating Gαs-coupled beta-adrenergic and prostaglandin E2 receptors and/or by suppressing signaling via inhibitory Gαi-coupled GABAB-receptors...
March 3, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28251655/the-vitamin-d-metabolite-ratio-vmr-as-a-predictor-of-functional-biomarkers-of-bone-health
#19
John Aloia, Melissa Fazzari, Albert Shieh, Ruban Dhaliwal, Mageda Mikhail, Andrew N Hoofnagle, Lou Ragolia
CONTEXT: The Vitamin D Metabolite Ratio (VMR) (Serum 24,25(OH)2 D3 /25(OH)D3 ) has been proposed as a biomarker of vitamin D sufficiency to replace serum 25(OH)D. OBJECTIVE: To examine the relationships of 24,25(OH)2 D3 and VMR to functional biomarkers of bone health following vitamin D supplementation. SETTING: An ambulatory research center. DESIGN: Serum from a previous research study of dose-response of PTH, calcium absorption and bone turnover to vitamin D supplementation was analyzed for vitamin D metabolites (25(OH)D, 24,25(OH)2 D3 )...
March 2, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28247565/development-and-validation-of-multivariable-models-to-predict-mortality-and-hospitalization-in-patients-with-heart-failure
#20
Adriaan A Voors, Wouter Ouwerkerk, Faiez Zannad, Dirk J van Veldhuisen, Nilesh J Samani, Piotr Ponikowski, Leong L Ng, Marco Metra, Jozine M Ter Maaten, Chim C Lang, Hans L Hillege, Pim van der Harst, Gerasimos Filippatos, Kenneth Dickstein, John G Cleland, Stefan D Anker, Aeilko H Zwinderman
INTRODUCTION: From a prospective multicentre multicountry clinical trial, we developed and validated risk models to predict prospective all-cause mortality and hospitalizations because of heart failure (HF) in patients with HF. METHODS AND RESULTS: BIOSTAT-CHF is a research programme designed to develop and externally validate risk models to predict all-cause mortality and HF hospitalizations. The index cohort consisted of 2516 patients with HF from 69 centres in 11 European countries...
March 1, 2017: European Journal of Heart Failure
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