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antimicrobial coating

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https://www.readbyqxmd.com/read/29138562/dual-uv-irradiation-based-metal-oxide-nanoparticles-for-enhanced-antimicrobial-activity-in-escherichia-coli-and-m13-bacteriophage
#1
Su-Eon Jin, Woochul Hwang, Hyo Jung Lee, Hyo-Eon Jin
Metal oxide (MO) nanoparticles have been studied as nano-antibiotics due to their antimicrobial activities even in antibiotic-resistant microorganisms. We hypothesized that a hybrid system of dual UV irradiation and MO nanoparticles would have enhanced antimicrobial activities compared with UV or MO nanoparticles alone. In this study, nanoparticles of ZnO, ZnTiO3, MgO, and CuO were selected as model nanoparticles. A dual UV collimated beam device of UV-A and UV-C was developed depending upon the lamp divided by coating...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29123398/triclosan-resistance-reversion-by-encapsulation-in-chitosan-coated-nanocapsule-containing-%C3%AE-bisabolol-as-core-development-of-wound-dressing
#2
João Guilherme B De Marchi, Denise S Jornada, Fernanda K Silva, Ana L Freitas, Alexandre M Fuentefria, Adriana R Pohlmann, Silvia S Guterres
The use of nanoparticles may be particularly advantageous in treating bacterial infections due to their multiple simultaneous mechanisms of action. Nanoencapsulation is particularly useful for lipophilic drugs. In this scenario, triclosan is considered a good candidate due to its lipophilicity, broad-spectrum activity, and safety. In the present study, we have developed and characterized an antimicrobial suspension of triclosan and α-bisabolol against pathogenic strains that are resistant (Pseudomonas aeruginosa) and susceptible (Escherichia coli, Staphylococcus aureus, and Candida albicans) to triclosan...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29123396/use-of-magnetic-nanoparticles-as-a-drug-delivery-system-to-improve-chlorhexidine-antimicrobial-activity
#3
Grażyna Tokajuk, Katarzyna Niemirowicz, Piotr Deptuła, Ewelina Piktel, Mateusz Cieśluk, Agnieszka Z Wilczewska, Jan R Dąbrowski, Robert Bucki
Nanotechnology offers new tools for developing therapies to prevent and treat oral infections, particularly biofilm-dependent disorders, such as dental plaques and endodontic and periodontal diseases. Chlorhexidine (CHX) is a well-characterized antiseptic agent used in dentistry with broad spectrum activity. However, its application is limited due to inactivation in body fluid and cytotoxicity toward human cells, particularly at high concentrations. To overcome these limitations, we synthesized nanosystems composed of aminosilane-coated magnetic nanoparticles functionalized with chlorhexidine (MNP@CHX)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29115828/zirconium-based-nanoscale-metal-organic-frameworks-poly-%C3%AE%C2%B5-caprolactone-mixed-matrix-membranes-as-effective-antimicrobials
#4
Ming Liu, Lei Wang, Xiaohua Zheng, Zhigang Xie
Metal-organic frameworks (MOF)-polymer mixed-matrix membranes (MMMs) have shown their superior performance in gas separation. However, their biological application has not been well explored yet. Herein, a series of Zirconium-based MOFs MMMs with high MOF loading and homogenous composition have been prepared through a facile drawdown coating process. Poly (ε-caprolactone) (PCL) has been selected as binder for its good biocompatibility and biodegradability. Zr-MOFs nanoparticles, UiO-66 and MOF-525, have been utilized as "filler" due to their superior chemical stability, well biological safety, and versatile functions...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29112913/multifunctional-nanocomplex-for-surface-enhanced-raman-scattering-imaging-and-near-infrared-photodynamic-antimicrobial-therapy-of-vancomycin-resistant-bacteria
#5
Zilong Zhou, Shanshan Peng, Minghao Sui, Shiguang Chen, Lishi Huang, Hui Xu, Tingting Jiang
Since vancomycin (Van)-resistant enterococci (VRE) strains first emerged as a serious threat to public health, extensive studies focused on optical imaging and antimicrobial therapy have been performed for monitoring and microbiological control. In this study, we developed silicon 2,3-naphthalocyanine dihydroxide (Nc) and Van functionalized silica-encapsulated, silver-coated gold nanoparticles (Au@AgNP@SiO2@Nc-Van) as a novel theranostic system for surface-enhanced Raman scattering (SERS) detection and antimicrobial photodynamic therapy (aPDT) of VRE strains...
November 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29111850/chitosan-based-coatings-in-the-prevention-of-intravascular-catheter-associated-infections
#6
Gracia Mendoza, Anna Regiel-Futyra, Alejandra Tamayo, Marta Monzon, Silvia Irusta, Miguel Angel de Gregorio, Agnieszka Kyzioł, Manuel Arruebo
Central venous access devices play an important role in patients with prolonged intravenous administration requirements. In the last years, the coating of these devices with bactericidal compounds has emerged as a potential tool to prevent bacterial colonization. Our study describes the modification of 3D-printed reservoirs and silicone-based catheters, mimicking central venous access devices, through different approaches including their coating with the well known biocompatible and bactericidal polymer chitosan, with the anionic polysaccharide alginate; also, plasma treated surfaces were included in the study to promote polymer adhesion...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29111051/antimicrobial-activity-of-catechol-functionalized-chitosan-versus-staphylococcus-epidermidis
#7
Andrea Amato, Luisa Maria Migneco, Andrea Martinelli, Loris Pietrelli, Antonella Piozzi, Iolanda Francolini
Protein mussel-inspired adhesive polymers, characterized by the presence of catechol groups, possess superior muco-adhesive properties and have great potentiality in wound healing. Suitable materials for wound dressing should properly combine muco-adhesiveness and antimicrobial activity. In this work, catechol-functionalized chitosan was obtained by reaction with hydrocaffeic acid (HCAF), in order to investigate how catechol introduction at different content could affect the intrinsic antimicrobial activity of the polymer itself...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29102795/enhanced-antimicrobial-activity-of-naturally-derived-bioactive-molecule-chitosan-conjugated-silver-nanoparticle-against-dental-implant-pathogens
#8
Darshan Devang Divakar, Nahla Talal Jastaniyah, Hazem Ganem Altamimi, Yasser Obaidallah Alnakhli, Muzaheed, Abdulaziz Abdullah Alkheraif, Shaista Haleem
Various metal coated implants have been tested against dental pathogens which causes increased biofilm formation and lead to failure of dental implants. The possibility of using nanoparticle together with native biomolecules to enhance the activity of such bioactive compound is also in progress. In this study we tested the efficacy of Ag conjugated chitosan nanoparticles as a prospective coating material of titanium dental implants. Known bioactive molecule chitosan was extracted from A. flavus Af09 and conjugated with Ag nanoparticle...
November 1, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29102240/emerging-biomedical-applications-of-enzyme-like-catalytic-nanomaterials
#9
REVIEW
David P Cormode, Lizeng Gao, Hyun Koo
Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recently, these catalytic nanomaterials with enzyme-mimetic properties have found new biomedical applications, from biofilm disruption to protection against neurodegeneration and tumor prevention. In this review we focus on recent in vivo studies demonstrating potential therapeutic uses of catalytic nanomaterials...
October 26, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29083929/covalent-grafting-of-antifouling-phosphorylcholine-based-copolymers-with-antimicrobial-nitric-oxide-releasing-polymers-to-enhance-infection-resistant-properties-of-medical-device-coatings
#10
Qiaohong Liu, Priyadarshini Singha, Hitesh Handa, Jason Locklin
Medical device coatings that resist protein adhesion and bacterial contamination are highly desirable in the healthcare industry. In this work, an antifouling zwitterionic terpolymer, 2-methacryloyloxyethyl phosphorylcholine-co-butyl methacrylate-co-benzophenone (BPMPC), is covalently grafted to a nitric oxide (NO) releasing antimicrobial biomedical grade copolymer of silicone-polycarbonate-urethane, CarboSil, to significantly enhance the biocompatibility, nonspecific protein repulsion and infection-resistant properties...
October 30, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29065670/gentamicin-released-from-porous-scaffolds-fabricated-by-stereolithography
#11
Somruethai Channasanon, Pareeya Udomkusonsri, Surapol Chantaweroad, Passakorn Tesavibul, Siriporn Tanodekaew
Porous oligolactide-hydroxyapatite composite scaffolds were obtained by stereolithographic fabrication. Gentamicin was then coated on the scaffolds afterwards, to achieve antimicrobial delivery ability to treat bone infection. The scaffolds examined by stereomicroscope, SEM, and μCT-scan showed a well-ordered pore structure with uniform pore distribution and pore interconnectivity. The physical and mechanical properties of the scaffolds were investigated. It was shown that not only porosity but also scaffold structure played a critical role in governing the strength of scaffolds...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29053255/fabrication-of-nontoxic-reduced-graphene-oxide-protein-nanoframework-as-sustained-antimicrobial-coating-for-biomedical-application
#12
Priyadarshani Choudhary, Thanusu Parandhaman, Baskaran Ramalingam, Natarajan Duraipandy, Manikantan Syamala Kiran, Sujoy K Das
Bacterial colonization on medical devices is a major concern in the healthcare industry. In the present study, we report synthesis of environmental sustainable reduced graphene oxide (rGO) on the large scale through biosynthetic route and its potential application for antibacterial coating on medical devices. HRTEM image depicts formation of graphene nanosheet, while DLS and ζ potential studies reveal that in aqueous medium the average hydrodynamic size and surface charge of rGO are 4410 ± 116 nm and -25...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29050607/physical-and-functional-properties-of-pectin-fish-gelatin-films-containing-the-olive-phenols-hydroxytyrosol-and-3-4-dihydroxyphenylglycol
#13
Alejandra Bermúdez-Oria, Guillermo Rodríguez-Gutiérrez, Blanca Vioque, Fátima Rubio-Senent, Juan Fernández-Bolaños
This study describes the development of a composite edible film based on pectin and fish skin protein capable of protecting food from microbial attack and oxidative degradation. The film was prepared with glycerol as plasticizer and the antioxidant and antimicrobial phenolic compounds hydroxytyrosol (HT) and 3,4-dihydroxyphenylglycol (DHPG), extracted from olive fruit, as active agents. The influence of the concentration of plasticizer and active HT/DHPG on the mechanical and functional properties of the films was investigated, with values of water vapor permeability (WVP) between 0...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29047302/a-self-assembled-clavanin-a-coated-amniotic-membrane-scaffold-for-the-prevention-of-biofilm-formation-by-ocular-surface-fungal-pathogens
#14
Santi M Mandal, Jahangir Khan, Denial Mahata, Suman Saha, Jayangshu Sengupta, Osmar N Silva, Subhayan Das, Mahitosh Mandal, Octavio L Franco
Amniotic membrane (AM) is frequently used in ophthalmologic surgery for rapid ocular surface reconstruction. Sometimes it may create a major problem with associated infections after biofilm formation over the membrane. To overcome this problem, AM was coated with the antimicrobial peptide clavanin A. The antifungal activity of clavanin A in the native and self-assembled form was determined against the common ocular surface pathogens Candida albicans, Aspergillus fumigatus, Alternaria sp. and Fusarium sp. Biofilm formation over the coated surface was significantly reduced in comparison with the uncoated membrane...
October 19, 2017: Biofouling
https://www.readbyqxmd.com/read/29046668/characterization-of-anti-bacterial-compounds-from-the-seed-coat-of-chinese-windmill-palm-tree-trachycarpus-fortunei
#15
Shakeel Ahmed, Huimin Liu, Aqeel Ahmad, Waheed Akram, Eman K N Abdelrahman, Fengming Ran, Wuling Ou, Shuang Dong, Qian Cai, Qiyun Zhang, Xiaohua Li, Sheng Hu, Xuebo Hu
The increasing of multidrug resistance in bacterial associated infections has impaired the current antimicrobial therapy and it forces the search for other alternatives. In this study, we aimed to find the in vitro antibacterial activity of seed coat of Trachycarpus fortunei against a panel of clinically important bacterial species. Ethanolic extracts of target tissues were fractionated through macro porous resin by column chromatography, using ethanol as an organic solvent with a concentration gradient of 0-100%, each along with 20% concentration increment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29039782/antibacterial-and-tribological-performance-of-carbonitride-coatings-doped-with-w-ti-zr-or-cr-deposited-on-aisi-316l-stainless-steel
#16
Sun-Hui Yao, Yen-Liang Su, Yu-Cheng Lai
Carbonitride (CNx) coatings have existed for several decades but are not well understood. Related studies have indicated that CNx coatings exhibit behaviors comparable to diamond-like carbon (DLC) coatings. Metal-doped CNx coatings are expected to show superior performance to single CNx coatings. In this study, a CNx coating and a group of CNx coatings with 6 at. % metal doping (W, Ti, Zr, or Cr) were prepared on biograde AISI 316L stainless steel (SS316L) substrates, and they were then characterized and studied for antibacterial and wear performance...
October 17, 2017: Materials
https://www.readbyqxmd.com/read/29034601/contact-active-antimicrobial-coatings-prepared-by-polymer-blending
#17
Rocío Cuervo-Rodríguez, Fátima López-Fabal, José L Gómez-Garcés, Alexandra Muñoz-Bonilla, Marta Fernández-García
Herein, contact active antimicrobial films are prepared by simply blending cationic amphiphilic block copolymers with commercial polystyrene (PS). The copolymers are prepared by combining atom transfer radical polymerization and "click chemistry." A variety of copolymers are synthesized, and composed of a PS segment and an antimicrobial block bearing flexible side chain with thiazole and triazole groups, 4-(1-(2-(4-methylthiazol-5-yl)ethyl)-1H-1,2,3-triazol-4-yl) butyl methacrylate (TTBM). The length of the TTBM block is varied as well as the alkylating agent...
November 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29034380/the-immobilization-of-antibiotic-loaded-polymeric-coatings-on-osteoarticular-ti-implants-for-the-prevention-of-bone-infections
#18
Dan Li, Pengfei Lv, Linfeng Fan, Yaoyi Huang, Fei Yang, Xifan Mei, Decheng Wu
Implant-associated infections in orthopaedic surgeries are very critical as they may hinder bone healing, cause implant failure and even progress to osteomyelitis. Drug-eluting implants for local delivery of antibiotics at surgical sites are thought to be promising in preventing infections. Herein, the antibiotic vancomycin was encapsulated in a poly(ethylene glycol) (PEG)-based hydrogel film that was covalently bound to Ti implants and subsequently covered by a PEG-poly(lactic-co-caprolactone) (PEG-PLC) membrane...
October 24, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29032456/silver-loaded-chitosan-coating-as-an-integrated-approach-to-face-titanium-implant-associated-infections-analytical-characterization-and-biological-activity
#19
Stefania Cometa, Maria A Bonifacio, Federico Baruzzi, Silvia de Candia, Maria M Giangregorio, Lorena C Giannossa, Manuela Dicarlo, Monica Mattioli-Belmonte, Luigia Sabbatini, Elvira De Giglio
The present work focuses on the idea to prevent and/or inhibit the colonization of implant surfaces by microbial pathogens responsible for post-operative infections, adjusting antimicrobial properties of the implant surface prior to its insertion. An antibacterial coating based on chitosan and silver was developed by electrodeposition techniques on poly(acrylic acid)-coated titanium substrates. When a silver salt was added during the chitosan deposition step, a stable and scalable silver incorporation was achieved...
October 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29029265/preclinical-testing-of-a-broad-spectrum-antimicrobial-endotracheal-tube-coated-with-an-innate-immune-synthetic-mimic
#20
Marjan M Hashemi, John Rovig, Jordan Bateman, Brett S Holden, Tomasz Modelzelewski, Iliana Gueorguieva, Martin von Dyck, Ronald Bracken, Carl Genberg, Shenglou Deng, Paul B Savage
Background: Endotracheal tubes provide an abiotic surface on which bacteria and fungi form biofilms, and the release of endotoxins and planktonic organisms can cause damaging inflammation and infections. Objectives: Ceragenins are small molecule mimics of antimicrobial peptides with broad-spectrum antibacterial and antifungal activity, and a ceragenin may be used to provide antimicrobial protection to the abiotic surface of an endotracheal tube. Methods: A hydrogel film, containing CSA-131, was generated on endotracheal tubes...
October 4, 2017: Journal of Antimicrobial Chemotherapy
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