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antimicrobial coating

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https://www.readbyqxmd.com/read/28433807/silver-nanoparticle-induced-toxicity-to-human-sperm-by-increasing-ros-reactive-oxygen-species-production-and-dna-damage
#1
Enyin Wang, Yan Huang, Qingyun Du, Yingpu Sun
Silver nanoparticles (AgNPs) have been used in medical products and industrial coatings, due to their antimicrobial properties. Excessive use of AgNPs can have adverse effects on the human body, however, their toxicity characteristics to human sperm and the potential mechanisms are not entirely clear. In this study, we exposed human sperm to different doses of AgNPs (0, 50μgml(-1), 100μgml(-1), 200μgml(-1) or 400μgml(-1)) for various times (15min, 30min, or 60min), followed by analyses of the sperm viability, motility and the ratio of abnormal to normal sperm...
April 14, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28425918/rhein-and-pdms-functionalized-c-c-composites-as-prosthetic-implants-for-bone-repair-application
#2
Zhenzhen Jia, Cui Yang, Jiajia Jiao, Xinyu Li, Dashuai Zhu, Yongchao Yang, Jingyi Yang, Yongzhe Che, Yun Lu, Xizeng Feng
A major issue in bone tissue engineering is the selection of biocompatible materials for implants, to reduce unwanted inflammatory reactions and promote cell adhesion. Bone tissues growth on suitable biomedical implants can shorten recovery and hospitalization after surgery. Therefore, a method to improve tissue-implant integration and healing would be of scientific and clinical interest. In this work, we permeated Polydimethylsiloxane (PDMS) into Carbon/carbon (C/C) composites (PDMS-C/C) and then coated it with 4, 5-dihydroxyanthraquinone-2-carboxylic acid (Rhein) to create Rhein-PDMS-C/C to increase its biocompatibility and reduce the occurrence of inflammatory reactions...
April 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28422479/on-demand-gas-to-liquid-process-to-fabricate-thermoresponsive-antimicrobial-nanocomposites-and-coatings
#3
Bijay Kumar Poudel, Jae Hong Park, Jeong Hoon Byeon
Antimicrobial material is emerging as a major component of the mitigation strategy against microbial growth on abiotic surfaces. In this work, a newly designed process is proposed to fabricate thermoresponsive antimicrobial nanocomposites (TANs) and coatings (TACs) as an on-demand system. Thermoresponsive polymer (TRP)-incorporated silver (Ag) nanocomposites with silica nanoparticles (SNPs) or carbon nanotubes (CNTs; Ag-SNP@TRP or Ag-CNT@TRP) were produced by a single-pass gas-to-liquid process. The SNPs or CNTs were first produced by spark ablation and successively injected for dispersal in a liquid cell containing polydimethylsiloxane, poly(N-isopropylacrylamide), and silver nitrate under ultrasound irradiation...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28420834/improving-the-efficacy-of-chlorhexidine-releasing-elastomerics-using-a-layerby-layer-coating-technique
#4
Hyun-Sun Jeon, Eun-Ha Jung, Si-Mook Kang, Eun-Song Lee, Jeong-Woo Lee, Baek-Il Kim
The aims of this study were to identify the optimal concentration of coated orthodontic elastomerics using a layer-by-layer technique that can release chlorhexidine (CHX) as an antimicrobial material, and to measure the physical properties and antimicrobial effects of the coated elastomerics. Ethyl cellulose (EC) was used as the polymer, and five study groups with various combinations of solvents (i.e., ethanol and dichloromethane [DCM]) were included. The coated elastomerics were evaluated with a spectrophotometer to confirm the release of CHX, and their surfaces were observed by SEM...
April 18, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28415518/antimicrobial-property-cytocompatibility-and-corrosion-resistance-of-zn-doped-zro2-tio2-coatings-on-ti6al4v-implants
#5
Ruoyun Wang, Xiaojing He, Yuee Gao, Xiangyu Zhang, Xiaohong Yao, Bin Tang
Zn-doped ZrO2/TiO2 porous coatings (Zn-ZrO2/TiO2) were prepared on the surface of titanium alloy (Ti6Al4V) by a hybrid approach of magnetron sputtering and micro-arc oxidation (MAO). The microstructures, phase constituents and elemental states of the coating were investigated by scanning electron microscope (SEM) equipped with energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The results demonstrate that the Zn-ZrO2/TiO2 coatings are porous and its thickness is approximately 13μm...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415499/antibacterial-effect-of-peo-coating-with-silver-on-aa7075
#6
P Cerchier, L Pezzato, K Brunelli, P Dolcet, A Bartolozzi, R Bertani, M Dabalà
In this work, plasma electrolytic oxidation (PEO) coatings were produced on AA7075 using alkaline solution containing silicates compounds and silver micrometric particles in order to give to the coating an antimicrobial effect. In the optic of circular economy, silver chloride derived from the acid pre-treatment of electronic scraps was used as raw material and successively silver powders were synthesized from silver chloride solution using glucose syrup as reducing agent. The coatings were characterized by scanning electron microscope (SEM), X-ray diffraction analysis (XRD), X-ray photoelectron spectroscopy (XPS), potentiodynamic polarization test and antimicrobial tests...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414173/affinity-interactions-drive-post-implantation-drug-filling-even-in-the-presence-of-bacterial-biofilm
#7
Erika L Cyphert, Sean T Zuckerman, Horst A von Recum, Julius N Korley
Current post-operative standard of care for surgical procedures, including device implantations, dictates prophylactic antimicrobial therapy, but a percentage of patients still develop infections. Systemic antimicrobial therapy needed to treat such infections can lead to downstream tissue toxicities and generate drug-resistant bacteria. To overcome issues associated with systemic drug administration, a polymer incorporating specific drug affinity has been developed with the potential to be filled or refilled with antimicrobials, post-implantation, even in the presence of bacterial biofilm...
April 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28409633/tunable-nitric-oxide-release-from-s-nitroso-n-acetylpenicillamine-via-catalytic-copper-nanoparticles-for-biomedical-applications
#8
Jitendra Pant, Marcus James Goudie, Sean P Hopkins, Elizabeth J Brisbois, Hitesh Handa
The quest for novel therapies to prevent bacterial infections and blood clots (thrombosis) is of utmost importance in biomedical research due to exponential growth in cases of thrombosis, blood infections, and the emergence of multi-drug resistant strains of bacteria. Endogenous nitric oxide (NO) is a cellular signaling molecule that plays a pivotal role in host immunity against pathogens, prevention of clotting, and regulation of systemic blood pressure among several biological functions. The physiological effect of NO is dose dependent, that necessitates the need of tunable release kinetics which is the objective of this study...
April 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28407425/antifouling-and-antimicrobial-biomaterials-an-overview
#9
REVIEW
Iolanda Francolini, Claudia Vuotto, Antonella Piozzi, Gianfranco Donelli
The use of implantable medical devices is a common and indispensable part of medical care for both diagnostic and therapeutic purposes. However, as side effect, the implant of medical devices quite often leads to the occurrence of difficult-to-treat infections, as a consequence of the colonization of their abiotic surfaces by biofilm-growing microorganisms increasingly resistant to antimicrobial therapies. A promising strategy to combat device-related infections is based on anti-infective biomaterials that either repel microbes, so they cannot attach to the device surfaces, or kill them in the surrounding areas...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28406604/an-efficient-and-benign-antimicrobial-depot-based-on-silver-infused-mos2
#10
Fangfang Cao, Enguo Ju, Yan Zhang, Zhenzhen Wang, Chaoqun Liu, Wei Li, Yanyan Huang, Kai Dong, Jinsong Ren, Xiaogang Qu
Silver nanoparticles (AgNPs) have been used as a broad-spectrum antimicrobial agent, whose toxicity originates from the localized release of Ag(+) ions. However, the residual AgNPs core could generate potential risk to humans and waste of noble metals. Herein, we infused the cysteine-modified molybdenum disulfide with minimum Ag(+) ions and coated with a layer of cationic polyelectrolyte to construct an efficient and benign antimicrobial depot. The system exhibited much enhanced broad-spectrum antibacterial activity compared with an equivalent amount of silver nitrate, owing to its increasing accessibility of released Ag(+) to the cell walls of microorganisms...
April 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28401217/activation-of-autophagy-by-elevated-reactive-oxygen-species-rather-than-released-silver-ions-promotes-cytotoxicity-of-polyvinylpyrrolidone-coated-silver-nanoparticles-in-hematopoietic-cells
#11
Lingying Zhu, Dawei Guo, Lili Sun, Zhihai Huang, Xiuyan Zhang, Wenjuan Ma, Jie Wu, Lun Xiao, Yun Zhao, Ning Gu
Silver nanoparticles (AgNPs) are the most commonly used engineered nanomaterials in commercialized products because of their antimicrobial activity. Previously, we have shown that polyvinylpyrrolidone (PVP)-coated AgNPs have an anti-leukemia effect against human myeloid leukemia cells; however, whether AgNPs are able to trigger autophagy in normal hematopoietic cells and the role of autophagy in AgNP-induced cytotoxicity remain unclear. In the current study, we observed that AgNPs were taken up by murine pro-B cells (Ba/F3), and then promoted accumulation of autophagosomes, which resulted from the induction of autophagy rather than the blockade of autophagic flux...
April 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28390963/targeting-biofilms-of-multidrug-resistant-bacteria-with-silver-oxynitrate
#12
Lindsay R Kalan, Deanna M Pepin, Imran Ul-Haq, Steve B Miller, Michelle E Hay, Rod Precht
A topical antimicrobial, silver oxynitrate (Ag7NO11), has recently become available that exploits the antimicrobial activity of ionic silver but has enhanced activity because highly oxidised silver atoms are stabilised with oxygen in a unique chemical formulation. The objective of this study was to use a multifaceted approach to characterise the spectrum of antimicrobial and antibiofilm activity of a wound dressing coated with Ag7NO11 at a concentration of 0.4 mg Ag/cm(2). Physiochemical properties that influence efficacy were also evaluated, and Ag7NO11 was found to release a high level of Ag ions, including Ag(2+) and Ag(3+), without influencing the pH of the medium...
April 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28386851/in-vivo-osseointegration-of-dental-implants-with-an-antimicrobial-peptide-coating
#13
X Chen, X C Zhou, S Liu, R F Wu, C Aparicio, J Y Wu
This study aimed to evaluate the in vivo osseointegration of implants with hydrophobic antimicrobial GL13K-peptide coating in rabbit femoral condyles by micro-CT and histological analysis. Six male Japanese Rabbits (4 months old and weighing 2.5 kg each) were included in this study. Twelve implants (3.75 mm wide, 7 mm long) were randomly distributed in two groups, with six implants in the experimental group coated with GL13K peptide and six implants in the control group without surface coating. Each implant in the test and the control group was randomly implanted in the left or right side of femoral condyles...
May 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28386730/inhibition-of-biofilm-formation-on-iodine-supported-titanium-implants
#14
Daisuke Inoue, Tamon Kabata, Kaori Ohtani, Yoshitomo Kajino, Toshiharu Shirai, Hiroyuki Tsuchiya
PURPOSE: We have developed iodine-supported titanium implants that suppress microbial activities and conducted in vivo and in vitro studies to determine their antimicrobial properties. METHODS: The implants were Ti-6Al-4 V titanium implants either untreated (Ti), treated with oxide film on the Ti surface by anodization (Ti-O), or treated with an iodine coating on oxidation film (Ti-I). The strain of bacteria used in this study was Gram-positive Staphylococcus aureus strain ATCC 25923...
April 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28385670/spatial-profiling-of-maytansine-during-the-germination-process-of-maytenus-senegalensis-seeds
#15
Dennis Eckelmann, Souvik Kusari, Michael Spiteller
The ecological role of maytansine, an important antineoplastic and antimicrobial compound with high cytotoxicity, particularly as a chemical defense compound has remained elusive since its discovery in the 1970s in Maytenus and Putterlickia plants. In the present study, we have used MALDI-imaging-HRMS to visualize the occurrence as well as spatial and temporal distribution of maytansine in a Maytenus senegalensis plant, seeds obtained from the mother plant during seeding stage, through the germination of the seeds, and finally up to the establishment of seedlings (or daughter plants)...
April 3, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28367838/anti-biofouling-function-of-amorphous-nano-ta2o5-coating-for-vo2-based-intelligent-windows
#16
Jinhua Li, Geyong Guo, Jiaxing Wang, Huaijuan Zhou, Hao Shen, Kelvin W K Yeung
From environmental and health perspectives, the acquisition of a surface anti-biofouling property holds important significance for the usability of VO2 intelligent windows. Herein, we firstly deposited amorphous Ta2O5 nanoparticles on VO2 film by the magnetron sputtering method. It was found that the amorphous nano-Ta2O5 coating possessed a favorable anti-biofouling capability against Pseudomonas aeruginosa as an environmental microorganism model, behind which lay the mechanism that the amorphous nano-Ta2O5 could interrupt the microbial membrane electron transport chain and significantly elevate the intracellular reactive oxygen species (ROS) level...
April 28, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28362344/proactive-approach-for-safe-use-of-antimicrobial-coatings-in-healthcare-settings-opinion-of-the-cost-action-network-amici
#17
Merja Ahonen, Anne Kahru, Angela Ivask, Kaja Kasemets, Siiri Kõljalg, Paride Mantecca, Ivana Vinković Vrček, Minna M Keinänen-Toivola, Francy Crijns
Infections and infectious diseases are considered a major challenge to human health in healthcare units worldwide. This opinion paper was initiated by EU COST Action network AMiCI (AntiMicrobial Coating Innovations) and focuses on scientific information essential for weighing the risks and benefits of antimicrobial surfaces in healthcare settings. Particular attention is drawn on nanomaterial-based antimicrobial surfaces in frequently-touched areas in healthcare settings and the potential of these nano-enabled coatings to induce (eco)toxicological hazard and antimicrobial resistance...
March 31, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28350872/rna-sequence-analysis-of-gene-expression-from-honeybees-apis-mellifera-infected-with-nosema-ceranae
#18
Bouabid Badaoui, André Fougeroux, Fabien Petit, Anna Anselmo, Chiara Gorni, Marco Cucurachi, Antonella Cersini, Anna Granato, Giusy Cardeti, Giovanni Formato, Franco Mutinelli, Elisabetta Giuffra, John L Williams, Sara Botti
Honeybees (Apis mellifera) are constantly subjected to many biotic stressors including parasites. This study examined honeybees infected with Nosema ceranae (N. ceranae). N. ceranae infection increases the bees energy requirements and may contribute to their decreased survival. RNA-seq was used to investigate gene expression at days 5, 10 and 15 Post Infection (P.I) with N. ceranae. The expression levels of genes, isoforms, alternative transcription start sites (TSS) and differential promoter usage revealed a complex pattern of transcriptional and post-transcriptional gene regulation suggesting that bees use a range of tactics to cope with the stress of N...
2017: PloS One
https://www.readbyqxmd.com/read/28350437/bacteria-activated-theranostic-nanoprobes-against-methicillin-resistant-staphylococcus-aureus-infection
#19
Zhiwei Zhao, Rong Yan, Xuan Yi, Jingling Li, Jiaming Rao, Zhengqing Guo, Yanmei Yang, Weifeng Li, Yong-Qiang Li, Chunying Chen
Despite numerous advanced imaging and sterilization techniques available nowadays, the sensitive in vivo diagnosis and complete elimination of drug-resistant bacterial infections remain big challenges. Here we report a strategy to design activatable theranostic nanoprobes against methicillin-resistant Staphylococcus aureus (MRSA) infections. This probe is based on silica nanoparticles coated with vancomycin-modified polyelectrolyte-cypate complexes (SiO2-Cy-Van), which is activated by an interesting phenomenon of bacteria-responsive dissociation of the polyelectrolyte from silica nanoparticles...
March 30, 2017: ACS Nano
https://www.readbyqxmd.com/read/28349700/fast-corroding-thin-magnesium-coating-displays-antibacterial-effects-and-low-cytotoxicity
#20
Sarah Zaatreh, David Haffner, Madlen Strauß, Katharina Wegner, Mareike Warkentin, Claudia Lurtz, Christiane Zamponi, Wolfram Mittelmeier, Bernd Kreikemeyer, Regine Willumeit-Römer, Eckhard Quandt, Rainer Bader
Bacterial colonisation and biofilm formation are characteristics of implant-associated infections. In search of candidates for improved prosthetic materials, fast corroding Mg-based coatings on titanium surfaces were examined for their cytotoxic and antimicrobial properties. Human osteoblasts and Staphylococcus epidermidis were each cultured on cylindrical Ti samples coated with a thin layer of Mg/Mg45Zn5Ca, applied via magnetron sputtering. Uncoated titanium samples served as controls. S. epidermidis was quantified by counting colony forming units...
March 28, 2017: Biofouling
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