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https://www.readbyqxmd.com/read/29786738/design-and-mechanistic-study-of-a-novel-gold-nanocluster-based-drug-delivery-system
#1
Qinzhen Li, Yiting Pan, Tiankai Chen, Yuanxin Du, Honghua Ge, Buchang Zhang, Jianping Xie, Haizhu Yu, Manzhou Zhu
Chemically-triggered drug delivery systems (DDSs) have been extensively studied as they do not require specialized equipment to deliver the drug and can deeply penetrate human tissue. However, their syntheses are complicated and they tend to be cytotoxic, which restricts their clinical utility. In this work, the self-regulated drug loading and release capabilities of peptide-protected gold nanoclusters (Pep-Au NCs) are investigated using vancomycin (Van) as the model drug. Gold nanoclusters (Au NCs) coated with a custom-designed pentapeptide are synthesized as drug delivery nanocarriers and loaded with Van - a spontaneous process reliant on the specific binding between Van and the custom-designed peptide...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29778961/uva-induced-antimicrobial-activity-of-zno-ag-nanocomposite-covered-surfaces
#2
Meeri Visnapuu, Merilin Rosenberg, Egle Truska, Ergo Nõmmiste, Andris Šutka, Anne Kahru, Mihkel Rähn, Heiki Vija, Kaja Orupõld, Vambola Kisand, Angela Ivask
Application of efficient antimicrobial surfaces has been estimated to decrease both, the healthcare-associated infections and the spread of antibiotic-resistant bacteria. In this paper, we prepared ZnO and ZnO/Ag nanoparticle covered surfaces and evaluated their antimicrobial efficacy towards a Gram-negative bacterial model (Escherichia coli), a Gram-positive bacterial model (Staphylococcus aureus) and a fungal model (Candida albicans) in the dark and under UVA illumination. The surfaces were prepared by spin coating aliquots of ZnO and ZnO/Ag nanoparticle suspensions onto glass substrates...
May 4, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29778319/anti-infective-biomaterials-with-surface-decorated-tachyplesin-i
#3
Qiong Xue, Xiao-Bin Liu, Yeh-Hsing Lao, Lin-Ping Wu, Dong Wang, Zhen-Qiang Zuo, Jun-Yu Chen, Jing Hou, Yuan-Yuan Bei, Xue-Fei Wu, Kam W Leong, Hua Xiang, Jing Han
Implants decorated with antimicrobial peptides (AMPs) can prevent infection and reduce the risk of creating antibiotic resistance. Yet the restricted mobility of surficial AMP often compromises its activity. Here, we report a simple but effective strategy to allow a more flexible display of AMP on the biomaterial surface and demonstrate its efficacy for wound healing. The AMP, tachyplesin I (Tac), is tagged with the polyhydroxyalkanoate-granule-associated protein (PhaP) and immobilized on haloarchaea-produced poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) via hydrophobic interaction...
May 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/29771856/vitamin-e-phosphate-coating-stimulates-bone-deposition-in-implant-related-infections-in-a-rat-model
#4
Arianna B Lovati, Marta Bottagisio, Susanna Maraldi, Martina B Violatto, Monica Bortolin, Elena De Vecchi, Paolo Bigini, Lorenzo Drago, Carlo L Romanò
BACKGROUND: Implant-related infections are associated with impaired bone healing and osseointegration. In vitro antiadhesive and antibacterial properties and in vivo antiinflammatory effects protecting against bone loss of various formulations of vitamin E have been demonstrated in animal models. However, to the best of our knowledge, no in vivo studies have demonstrated the synergistic activity of vitamin E in preventing bacterial adhesion to orthopaedic implants, thus supporting the bone-implant integration...
June 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29768230/screening-the-uv-blocking-and-antimicrobial-properties-of-herbal-nanoparticles-prepared-from-aloe-vera-leaves-for-textile-applications
#5
Karthik Subramani, Balu Kolathupalayam Shanmugam, Suriyaprabha Rangaraj, Manivasakan Palanisamy, Prabu Periasamy, Rajendran Venkatachalam
Nanomaterials play a vital role in textile industries due to their unique properties and applications. There is an increase in the use of nanoscale phyto products in textiles to control the bacterial infection in fabrics. Here, natural herbal nanoparticles of different sizes were prepared from shade-dried Aloe vera plant leaves using ball milling technique without any additives. The amorphous herbal A. vera nanoparticles possess an average particle size of 40 ± 2 nm and UV-absorption maximum at 269 nm...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29767296/evaluating-the-antimicrobial-apoptotic-and-cancer-cell-gene-delivery-properties-of-protein-capped-gold-nanoparticles-synthesized-from-the-edible-mycorrhizal-fungus-tricholoma-crassum
#6
Arpita Basu, Sarmishtha Ray, Supriyo Chowdhury, Arnab Sarkar, Deba Prasad Mandal, Shamee Bhattacharjee, Surekha Kundu
Biosynthesis of gold nanoparticles of distinct geometric shapes with highly functional protein coats without additional capping steps is rarely reported. This study describes green synthesis of protein-coated gold nanoparticles for the first time from the edible, mycorrhizal fungus Tricholoma crassum (Berk.) Sacc. The nanoparticles were of the size range 5-25 nm and of different shapes. Spectroscopic analysis showed red shift of the absorption maxima with longer reaction period during production and blue shift with increase in pH...
May 16, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29765680/the-relationship-between-substrate-morphology-and-biological-performances-of-nano-silver-loaded-dopamine-coatings-on-titanium-surfaces
#7
Weibo Zhang, Shuang Wang, Shaohua Ge, Jialong Chen, Ping Ji
Biomedical device-associated infection (BAI) and lack of osseointegration are the main causes of implant failure. Therefore, it is imperative for implants not only to depress microbial activity and biofilm colonization but also to prompt osteoblast functions and osseointegration. As part of the coating development for implants, the interest of in vitro studies on the interaction between implant substrate morphology and the coating's biological performances is growing. In this study, by harnessing the adhesion and reactivity of bioinspired polydopamine, nano-silver was successfully anchored onto micro/nanoporous as well as smooth titanium surfaces to analyse the effect of substrate morphology on biological performances of the coatings...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29760549/nanostructured-ag-substituted-fluorhydroxyapatite-tio-2-coatings-for-enhanced-bactericidal-effects-and-osteoinductivity-of-ti-for-biomedical-applications
#8
Yong Huang, Guiqin Song, Xiaotong Chang, Zhenhui Wang, Xuejiao Zhang, Shuguang Han, Zhuobin Su, Hejie Yang, Dongdong Yang, Xiaojun Zhang
Background: Poor mechanical properties, undesirable fast dissolution rate, and lack of antibacterial activity limit the application of hydroxyapatite (HA) as an implant coating material. To overcome these limitations, a hybrid coating of Ag+ -substituted fluorhydroxyapatite and titania nanotube (TNT) was prepared. Methods: The incorporation of silver into the HA-TiO2 hybrid coating improves its antimicrobial properties. The addition of F as a second binary element increases the structural stability of the coating...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29758538/preparation-and-characterization-of-iron-oxide-magnetic-nanoparticles-functionalized-by-nisin
#9
Ruta Gruskiene, Tatjana Krivorotova, Ramune Staneviciene, Dalius Ratautas, Elena Serviene, Jolanta Sereikaite
Nisin is a known bacteriocin approved as a food additive for food preservation. It exhibits a wide spectrum antimicrobial activity against Gram-positive bacteria. Iron oxide magnetic nanoparticles were synthesized and characterized by X-ray diffraction method. A main part of iron oxide nanoparticles was found to be maghemite though a small quantity of magnetite could also be present. Magnetic nanoparticles were stabilized by citric, ascorbic, gallic or glucuronic acid coating. Stable iron oxide magnetic nanoparticles were functionalized by nisin using a simple and low cost adsorption method...
May 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29750327/do-nano-crystalline-silver-coated-hernia-grafts-reduce-infection
#10
Elif Nergiz Adıgüzel, Ebru Esen, Gökçe Aylaz, Betül Keskinkılıç Yağız, Mehmet Kıyan, Aydın Doğan, Ali Ekrem Ünal
PURPOSE: Inguinal hernia repairs are the most common interventions in adults in general surgery clinics. Depending on the type of mesh and repair, the incidence of mesh-related infection ranges from 0.6 to 8%. Methicillin-resistant Staphylococcus aureus is the most common microorganism causing graft infection. The aim of this study was to investigate the efficacy of nano-crystalline silver-coated polypropylene grafts against graft infection created with MRSA in rats. METHODS: A total of 60 female, Wistar albino rats were used in the study...
May 10, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29744444/recyclable-magnetite-silver-heterodimer-nanocomposites-with-durable-antibacterial-performance
#11
Chunyan Yong, Xiaoqin Chen, Qian Xiang, Qiang Li, Xiaodong Xing
There is a significant need for magnetite-silver nanocomposites that exhibit durable and recyclable antimicrobial activity. In this study, magnetic iron oxide nanoparticles (Fe3 O4 NPs) coated with ethylenediamine-modified chitosan/polyacrylic acid copolymeric layer (Fe3 O4 @ECS/PAA) were fabricated. Subsequently, directly deposited silver (Ag) NPs procedure was carried out to form the antibacterial heterodimers of Fe3 O4 @ECS/PAA-Ag NPs. The composition and morphology of the resultant nanostructures were confirmed by FT-IR, XRD, TEM and TGA...
March 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29736777/silver-and-copper-addition-enhances-the-antimicrobial-activity-of-calcium-hydroxide-coatings-on-titanium
#12
M Meininger, S Meininger, J Groll, U Gbureck, C Moseke
Electrochemically assisted deposition of Ca(OH)2 (Portlandite) coatings on titanium surfaces has been proven as a promising method to provide the substrate with a most desirable combination of significant bacterial growth reduction on one hand and good biocompatibility on the other. Due to the rapid in vivo transformation of Ca(OH)2 to hydroxyapatite, the antimicrobial activity will be an ephemeral property of the coating when implanted into the human body. In this study, the ability to reduce bacterial growth of such portlandite coatings was significantly enhanced by an ionic modification with copper and silver ions...
May 7, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29736299/ultrasensitive-electrochemical-determination-of-metronidazole-based-on-polydopamine-carboxylic-multi-walled-carbon-nanotubes-nanocomposites-modified-gce
#13
Satar Tursynbolat, Yrysgul Bakytkarim, Jianzhi Huang, Lishi Wang
An ultrasensitive electrochemical sensor based on polydopamine/carboxylic multi-walled carbon nanotubes (MWCNTs-COOH) nanocomposites modified glassy carbon electrode (GCE) was presented in this work, which has been developed for highly selective and highly sensitive determination of an antimicrobial drug, metronidazole. The preparation of polydopamine/MWCNTs-COOH nanocomposites/GCE sensor is simple and possesses high reproducible, where polydopamine can be coated on the surface of MWCNTs-COOH via a simple electropolymerization process...
April 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29733574/quaternized-pei-pnipaam-based-antimicrobial-reverse-thermal-gel-a-potential-for-surgical-incision-drapes
#14
Maria Bortot, Melissa Ronni Laughter, Madia Stein, Adam Rocker, Vikas Patel, Daewon Park
OBJECTIVES: A quaternized reverse thermal gel aimed at replacing current surgical incision drapes (SID) was designed and characterized. The antimicrobial efficacy of the quaternized reverse thermal gel was analyzed using both in vitro and in vivo models and was compared to standard SIDs. METHODS: Polymer characterization was completed using both nuclear magnetic resonance (1H NMR) and lower critical solution temperature (LCST) analysis. Biocompatibility was assessed using a standard cell viability assay...
May 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29727575/antimicrobial-and-antifouling-polymeric-agents-for-surface-functionalization-of-medical-implants
#15
Qiang Zeng, Yiwen Zhu, Bingran Yu, Yujie Sun, Xiaokang Ding, Chen Xu, Yu-Wei Wu, Zhihui Tang, Fu-Jian Xu
Combating implant-associated infections is an urgent demand due to the increasing numbers in surgical operations such as joint replacements and dental implantations. Surface functionalization of implantable medical devices with polymeric antimicrobial and antifouling agents is an efficient strategy to prevent bacterial fouling and associated infections. In this work, antimicrobial and antifouling branched polymeric agents (GPEG and GEG) were synthesized via ring-opening reaction involving gentamicin and ethylene glycol species...
May 4, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29720319/ag-nanoencapsulation-for-antimicrobial-applications
#16
Sarah-Luise Abram, Jacinthe Gagnon, Magdalena Priebe, Nelly Hérault, Katharina M Fromm
Biomaterial-related infections remain a significant challenge in medicine. Antimicrobial materials on the basis of Ag nanoparticles represent a promising solution for this issue. Therefore several Ag-containing nanocontainers and nanorattles have been synthesized and characterized that exhibit remarkable control over the release of Ag+ as antimicrobial active species. Their biological evaluation against prokaryotic as well as eukaryotic cells reveals that they fulfill the prerequisites for applications as antimicrobial implant coatings...
April 25, 2018: Chimia
https://www.readbyqxmd.com/read/29719667/effects-of-chitosan-edible-coating-containing-grape-seed-extract-on-the-shelf-life-of-refrigerated-rainbow-trout-fillet
#17
Parviz Hassanzadeh, Mehran Moradi, Nasim Vaezi, Mir-Hassan Moosavy, Razzagh Mahmoudi
In recent years, use of edible coatings as carriers of food additives and antimicrobial compounds has been considered in fishery products. This study was carried out to evaluate the effects of 2.00% chitosan coating singly and combined with 0.10% grape seed extract (GSE) on microbial (mesophils and psychrophils counts), chemical (thiobarbituric acid; TBA), pH and peroxide value (PV) and sensorial properties of rainbow trout fillet stored at 4 ° C over a period of 15 days. The coating had a significant effect in reducing aerobic mesophilic and psychrophilic bacteria counts...
2018: Veterinary Research Forum
https://www.readbyqxmd.com/read/29718664/recent-progress-in-polymer-research-to-tackle-infections-and-antimicrobial-resistance
#18
Mohini Mohan Konai, Brinta Bhattacharjee, Sreyan Ghosh, Jayanta Haldar
Global health is increasingly threatened by the rapid emergence of drug-resistant microbes. The ability of these microbes to form biofilm has further exacerbated the scenario leading to notorious infections which are almost impossible to treat. To address this clinical threat, various antimicrobial polymers, polymer-based antimicrobial hydrogels and polymer-coated antimicrobial surfaces have been developed in the recent past. This review aims to discuss such polymer-based antimicrobial strategies, with a focus on their current advancement in the field...
May 2, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29710862/antimicrobial-activity-of-new-materials-based-on-lavender-and-basil-essential-oils-and-hydroxyapatite
#19
Daniela Predoi, Simona Liliana Iconaru, Nicolas Buton, Monica Luminita Badea, Luminita Marutescu
This study presents, for the first-time, the results of a study on the hydrodynamic diameter of essential oils (EOs) of basil and lavender in water, and solutions of EOs of basil (B) and lavender (L) and hydroxyapatite (HAp). The possible influence of basil and lavender EOs on the size of hydroxyapatite nanoparticles was analyzed by Scanning Electron Microscopy (SEM). We also investigated the in vitro antimicrobial activity of plant EOs and plant EOs hydroxyapatite respectively, against Gram-positive bacteria (methicillin-resistant Staphylococcus aureus 1144 (MRSA 1144) and S...
April 30, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29704519/hemocyanin-derived-phenoloxidase-reaction-products-display-anti-infective-properties
#20
Christopher J Coates, James Talbot
Hemocyanin is a multi-functional protein located in the hemolymph (blood) of certain arthropods and molluscs. In addition to its well-defined role in oxygen transport, hemocyanin can be converted into a phenoloxidase-like enzyme. Herein, we tested the antimicrobial properties of horseshoe crab (Limulus polyphemus) hemocyanin-derived phenoloxidase reaction products using broad ranges of phenolic substrates (e.g. l -DOPA) and microbial targets (Gram-positive/negative bacteria, yeast). The enzyme-catalysed turnover of several substrates generated (by)products that reduced significantly the number of colony forming units...
April 25, 2018: Developmental and Comparative Immunology
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