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https://www.readbyqxmd.com/read/28076665/carbohydrate-lectin-interactions-an-unexpected-contribution-to-affinity
#1
Giulio Navarra, Pascal Zihlmann, Roman P Jakob, Katia Stangier, Roland C Preston, Said Rabbani, Martin Smiesko, Bea Wagner, Timm Maier, Beat Ernst
Uropathogenic E. coli exploit the PapG-II adhesin for infecting host cells of the kidney; moreover, the expression of PapG-II located at the tip of bacterial pili has been correlated with the onset of pyelonephritis in humans, a potentially life-threatening condition. It was envisaged that the blocking of PapG-II, and thus bacterial adhesion, embodies a viable therapeutic alternative to conventional antibiotic treatment. Within our search for potent PapG-II antagonists, we observed an increase in affinity when tetrasaccharide 1, the natural ligand of PapG-II in human kidneys, was elongated to hexasaccharide 2, although the additional Siaα(2-3)Gal extension is not in direct contact with the lectin...
January 11, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28068663/collectin-kidney-1-plays-an-important-role-in-innate-immunity-against-streptococcus-pneumoniae-infection
#2
Insu Hwang, Kenichiro Mori, Katsuki Ohtani, Yasuyuki Matsuda, Nitai Roy, YounUck Kim, Yasuhiko Suzuki, Nobutaka Wakamiya
Collectins are C-type lectins that are involved in innate immunity as pattern recognition molecules. Recently, collectin kidney 1 (CL-K1) has been discovered, and in vitro studies have shown that CL-K1 binds to microbes and activates the lectin complement pathway. However, in vivo functions of CL-K1 against microbes have not been elucidated. To investigate the biological functions of CL-K1, we generated CL-K1 knockout (CL-K1-/-) mice and then performed a Streptococcus pneumoniae infection analysis. First, we found that recombinant human CL-K1 bound to S...
January 10, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28017903/characterization-and-expression-analysis-of-an-intelectin-gene-from-megalobrama-amblycephala-with-excellent-bacterial-binding-and-agglutination-activity
#3
Zhujin Ding, Xiaoheng Zhao, Qifeng Zhan, Lei Cui, Qianhui Sun, Li Lin, Weimin Wang, Hong Liu
Intelectin is a recently discovered lectin that plays vital roles in the innate immune response, iron metabolism and early embryogenesis. The structure, expression pattern and function of intelectin in mammals and amphibians have been well studied, while not well known in fish. In this study, we cloned a intelectin (MamINTL) gene from blunt snout bream (Megalobrama amblycephala), examined its expression patterns and explored its roles in innate immune response. The MamINTL cDNA encoded 312 amino acids, with a pro-protein of 34 kDa...
December 22, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28017324/the-pattern-recognition-receptor-mincle-is-essential-for-maintaining-the-m1-macrophage-phenotype-in-acute-renal-inflammation
#4
Lin L Lv, Patrick Ming-Kuen Tang, Chun J Li, Yong K You, Jinhong Li, Xiao-Ru Huang, Jun Ni, Min Feng, Bi C Liu, Hui-Yao Lan
Mincle (macrophage-inducible C-type lectin, Clec4e) is a transmembrane pattern recognition receptor involving the innate immunity, but its role in kidney disease is still unexplored. In the obstructed kidney of the unilateral ureteral obstruction model of renal injury, Mincle was specifically detected in the infiltrating M1 macrophages (CD68(+)iNOS(+) cells) on day one but was rapidly reduced following reduction of M1 macrophages during the progression of kidney injury. Interestingly, Mincle-expressing macrophages were progressively increased in the cisplatin-induced acute kidney injury model, where iNOS expression was detected in the CD68(+) cells following Mincle induction...
December 22, 2016: Kidney International
https://www.readbyqxmd.com/read/27960039/physiological-and-pathophysiological-roles-of-interaction-between-clec-2-and-podoplanin-partners-from-in-utero-to-adulthood
#5
REVIEW
Katsue Suzuki-Inoue, Makoto Osada, Yukio Ozaki
A platelet activation receptor, C-type lectin-like receptor 2 (CLEC-2) has been identified as a receptor for a platelet activating snake venom, rhodocytin. CLEC-2 protein is highly expressed in platelets/megakaryocytes and at lower levels on liver Kupffer cells. Later, podoplanin has been revealed as an endogenous ligand for CLEC-2. Podoplanin is expressed in certain types of tumor cells, fibroblastic reticular cells (FRCs) in lymph nodes, kidney podocytes, and lymphatic endothelial cells, but not in vascular endothelial cells...
December 13, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27935765/gb3-binding-lectins-as-potential-carriers-for-transcellular-drug-delivery
#6
Stefan K Müller, Isabel Wilhelm, Thomas Schubert, Katharina Zittlau, Anne Imberty, Josef Madl, Thorsten Eierhoff, Roland Thuenauer, Winfried Römer
OBJECTIVES: Epithelial cell layers as well as endothelia forming the blood-brain barrier can drastically reduce the efficiency of drug targeting. Our goal was to investigate lectins recognizing the glycosphingolipid globotriaosylceramide (Gb3) for their potential as carriers for transcytotic drug delivery. METHODS: We utilized an in vitro model based on Madin-Darby canine kidney cells transfected with Gb3 synthase to characterize transcytosis of the Gb3-binding lectins LecA from Pseudomonas aeruginosa and the B-subunit of Shiga toxin (StxB)...
December 16, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27863511/analysis-of-complement-biomarkers-in-systemic-sclerosis-indicates-a-distinct-pattern-in-scleroderma-renal-crisis
#7
Marcin Okrój, Martin Johansson, Tore Saxne, Anna M Blom, Roger Hesselstrand
BACKGROUND: The complement system has been implicated in pathogenesis of systemic sclerosis (SSc). The goal of the present study was to evaluate improved complement biomarkers in SSc. METHODS: The presence of C4d, reflecting activation of the classical/lectin pathways, C3bBbP corresponding to activation of the alternative pathway, and soluble terminal complement complexes (all complement pathways), was measured in plasma samples by enzyme-linked immunosorbent assay and correlated to clinical parameters...
November 18, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27829066/galectin-3-blockade-reduces-renal-fibrosis-in-two-normotensive-experimental-models-of-renal-damage
#8
Ernesto Martinez-Martinez, Jaime Ibarrola, Laurent Calvier, Amaya Fernandez-Celis, Celine Leroy, Victoria Cachofeiro, Patrick Rossignol, Natalia Lopez-Andres
BACKGROUND: Galectin-3 (Gal-3), a β-galactoside-binding lectin, is increased in kidney injury and its pharmacological blockade reduces renal damage in acute kidney injury, hyperaldosteronism or hypertensive nephropathy. We herein investigated the effects of pharmacological Gal-3 inhibition by modified citrus pectin (MCP) in early renal damage associated with obesity and aortic stenosis (AS). RESULTS: Gal-3 was upregulated in kidneys from high fat diet (HFD) rats and in animals with partial occlusion of ascending aorta (AS)...
2016: PloS One
https://www.readbyqxmd.com/read/27826126/the-expression-patterns-of-tetratricopeptide-repeat-domain-36-ttc36
#9
Yuru Zhou, Qingling He, Jihui Chen, Yunhong Liu, Zhaomin Mao, Zhongshi Lyu, Dongsheng Ni, Yaoshui Long, Pan Ju, Jianing Liu, Yuping Gu, Qin Zhou
Tetratricopeptide repeat domain 36 (Ttc36), whose coding protein belongs to tetratricopeptide repeat (TPR) motif family, has not been studied extensively. We for the first time showed that Ttc36 is evolutionarily conserved across mammals by bioinformatics. Rabbit anti-mouse Ttc36 polyclonal antibody was generated by injecting synthetic full-length peptides through "antigen intersection" strategy. Subsequently, we characterized Ttc36 expression profile in mouse, showing its expression in liver and kidney both from embryonic day 15...
November 2016: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/27760523/low-level-of-map44-an-inhibitor-of-the-lectin-complement-pathway-and-long-term-graft-and-patient-survival-a-cohort-study-of-382-kidney-recipients
#10
Julia Smedbråten, Geir Mjøen, Anders Hartmann, Anders Åsberg, Halvor Rollag, Tom Eirik Mollnes, Leiv Sandvik, Morten W Fagerland, Steffen Thiel, Solbjørg Sagedal
BACKGROUND: Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient's native immune system. The complement system is an essential component of the innate immunity. The aim of the present study was to investigate the association of effector molecules of the lectin complement pathway with graft and patient survival after kidney transplantation. METHODS: Two mannan-binding lectin (MBL) associated proteases, MASP-2 and MASP-3 (activators of the lectin pathway) and two MBL-associated proteins, MAp44 and MAp19 (inhibitors of the lectin pathway) were measured at the time of transplantation in 382 patients (≥17 years old) transplanted in 2000-2001...
October 18, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27707997/mannan-binding-lectin-associated-serine-protease-1-3-cleavage-of-pro-factor-d-into-factor-d-in-vivo-and-attenuation-of-collagen-antibody-induced-arthritis-through-their-targeted-inhibition-by-rna-interference-mediated-gene-silencing
#11
Nirmal K Banda, Sumitra Acharya, Robert I Scheinman, Gaurav Mehta, Marilyne Coulombe, Minoru Takahashi, Hideharu Sekine, Steffen Thiel, Teizo Fujita, V Michael Holers
The complement system is proposed to play an important role in the pathogenesis of rheumatoid arthritis (RA). The complement system mannan-binding lectin-associated serine proteases (MASP)-1/3 cleave pro-factor D (proDf; inactive) into Df (active), but it is unknown where this cleavage occurs and whether inhibition of MASP-1/3 is a relevant therapeutic strategy for RA. In the present study, we show that the cleavage of proDf into Df by MASP-1/3 can occur in the circulation and that inhibition of MASP-1/3 by gene silencing is sufficient to ameliorate collagen Ab-induced arthritis in mice...
November 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27695439/encapsulation-into-stealth-liposomes-enhances-the-antitumor-action-of-recombinant-cratylia-mollis-lectin-expressed-in-escherichia-coli
#12
Cássia R A da Cunha, Luís C N da Silva, Fábio J F Almeida, Milena S Ferraz, Nathalia Varejão, Marina F de Souza Cartaxo, Rita de Cássia M de Miranda, Francisco C A de Aguiar, Noemia P da Silva Santos, Luana C B B Coelho, Nereide S Santos-Magalhães, Maria T Dos Santos Correia
This study evaluated the in vivo antitumor potential of the recombinant lectin from seeds of Cratylia mollis (rCramoll) expressed in Escherichia coli, free or encapsulated in stealth liposomes, using mice transplanted with sarcoma 180. rCramoll-loaded stealth liposomes (rCramoll-lipo) were formulated by hydration of the lipid film followed by cycles of freezing and thawing, and about 60% of rCramoll was encapsulated. This novel preparation showed particle size, polydispersity index, and pH suitable for the evaluation of antitumor activity in vivo...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27666815/role-of-galectin-3-in-autoimmune-and-non-autoimmune-nephropathies
#13
REVIEW
Francesca Saccon, Mariele Gatto, Anna Ghirardello, Luca Iaccarino, Leonardo Punzi, Andrea Doria
Galectins are evolutionary conserved β-galactoside binding proteins with a carbohydrate-recognition domain (CRD) of approximately 130 amino acids. In mammals, 15 members of the galectin family have been identified and classified into three subtypes according to CRD organization: prototype, tandem repeat-type and chimera-type galectins. Galectin-3 (gal-3) is the only chimera type galectin in vertebrates containing one CRD linked to an unusual long N-terminal domain which displays non-lectin dependent activities...
January 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27660287/nicotine-mediates-cd161a-renal-macrophage-infiltration-and-premature-hypertension-in-the-spontaneously-hypertensive-rat
#14
Sailesh C Harwani, Jason Ratcliff, Fayyaz S Sutterwala, Zuhair K Ballas, David K Meyerholz, Mark W Chapleau, Francois M Abboud
RATIONALE: Renal inflammation contributes to the pathophysiology of hypertension. CD161a(+) immune cells are dominant in the (SHR) spontaneously hypertensive rat and expand in response to nicotinic cholinergic activation. OBJECTIVE: We aimed to phenotype CD161a(+) immune cells in prehypertensive SHR after cholinergic activation with nicotine and determine if these cells are involved in renal inflammation and the development of hypertension. METHODS AND RESULTS: Studies used young SHR and WKY (Wistar-Kyoto) rats...
October 28, 2016: Circulation Research
https://www.readbyqxmd.com/read/27605771/effect-of-nigella-sativa-alcoholic-extract-and-oil-as-well-as-phaseolus-vulgaris-kidney-bean-lectin-on-the-ultrastructure-of-trichomonas-vaginalis-trophozoites
#15
Heba AbdelKader Aminou, Yosra Hussein Alam-Eldin, Hanan Ahmed Hashem
Trichomonas vaginalis is a parasitic protozoan that is the aetiological agent of trichomoniasis, the most common non-viral sexually transmitted disease worldwide. Currently, the compound of choice for the treatment of T. vaginalis infections is metronidazole, however, it has many side effects and an increase in metronidazole-resistant trichomoniasis has been observed. Medicinal plants could be a source of new antiprotozoal drugs with high activity, low toxicity and lower price. The present work was carried out to investigate the therapeutic potential of Nigella sativa alcoholic extract and oil, as well as Phaseolus vulgaris (kidney bean) lectin and their in vitro activity on the ultrastructure of T...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27560685/transport-of-gold-nanoparticles-by-vascular-endothelium-from-different-human-tissues
#16
Radka Gromnicova, Mehmet Kaya, Ignacio A Romero, Phil Williams, Simon Satchell, Basil Sharrack, David Male
The selective entry of nanoparticles into target tissues is the key factor which determines their tissue distribution. Entry is primarily controlled by microvascular endothelial cells, which have tissue-specific properties. This study investigated the cellular properties involved in selective transport of gold nanoparticles (<5 nm) coated with PEG-amine/galactose in two different human vascular endothelia. Kidney endothelium (ciGENC) showed higher uptake of these nanoparticles than brain endothelium (hCMEC/D3), reflecting their biodistribution in vivo...
2016: PloS One
https://www.readbyqxmd.com/read/27475991/complement-analysis-2016-clinical-indications-laboratory-diagnostics-and-quality-control
#17
REVIEW
Zoltán Prohászka, Bo Nilsson, Ashley Frazer-Abel, Michael Kirschfink
In recent years, complement analysis of body fluids and biopsies, going far beyond C3 and C4, has significantly enhanced our understanding of the disease process. Such expanded complement analysis allows for a more precise differential diagnosis and for critical monitoring of complement-targeted therapy. These changes are a result of the growing understanding of the involvement of complement in a diverse set of disorders. To appreciate the importance of proper complement analysis, it is important to understand the role it plays in disease...
November 2016: Immunobiology
https://www.readbyqxmd.com/read/27473744/successful-abo-incompatible-renal-transplantation-%C3%A2-blood-group-a1b-donor-into-a2b-recipient-with-anti-a1-isoagglutinins
#18
Emmanuel A Fadeyi, Robert J Stratta, Alan C Farney, Gregory J Pomper
OBJECTIVES: Transplantation of the blood group A2B in a recipient was successfully performed in the setting of receiving a deceased donor kidney from an "incompatible" A1B donor. METHODS: The donor and recipient were both typed for ABO blood group, including ABO genotyping. The donor and recipient were tested for ABO, non-ABO, and human leukocyte antigen (HLA) antibodies. The donor and recipient were typed for HLA antigens, including T- and B-flow cytometry crossmatch tests...
August 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27418461/molecular-cloning-and-characterization-of-a-c-type-lectin-in-yellow-catfish-tachysurus-fulvidraco
#19
F Ke, H B Zhang, Y Wang, L F Hou, H J Dong, Z F Wang, G W Pan, X Y Cao
This study represents the first report of a C-type lectin (ctl) in yellow catfish Tachysurus fulvidraco. The complete sequence of ctl complementary (c)DNA consisted of 685 nucleotides. The open reading frame potentially encoded a protein of 177 amino acids with a calculated molecular mass of c.y 20.204 kDa. The deduced amino-acid sequence contained a signal peptide and a single carbohydrate recognition domain with four cysteine residues and GlnProAsp (QPD) and TrpAsnAsp (WND) motifs. Ctl showed the highest identity (56...
September 2016: Journal of Fish Biology
https://www.readbyqxmd.com/read/27377710/the-collectins-cl-l1-cl-k1-and-cl-p1-and-their-roles-in-complement-and-innate-immunity
#20
REVIEW
Soren W K Hansen, Katsuki Ohtani, Nitai Roy, Nobutaka Wakamiya
Both the complement system and collectins play important roles in our innate immune system. The collectins, which are characterized by their inclusion of a collagen-like region and a calcium-dependent carbohydrate recognition domain, are pattern recognition molecules and include the well characterized proteins mannan-binding lectin (MBL) and the surfactant proteins SP-A/-D. Collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1) and collectin placenta 1 (CL-P1) are the most recently discovered collectins. Although their function is still under investigation, accumulating information suggests that CL-L1, CL-K1 and CL-P1 play important roles in host defense by recognizing a variety of microorganisms and interacting with effector proteins, including complement components...
October 2016: Immunobiology
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