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https://www.readbyqxmd.com/read/28611987/complement-in-kidney-transplantation
#1
REVIEW
Marek Cernoch, Ondrej Viklicky
The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins C3a and C5a, possessing a vast spectrum of immune functions, and the assembly of terminal complement cascade, capable of direct cell lysis. The activation processes are tightly regulated; inappropriate activation of the complement cascade plays a significant role in many renal diseases including organ transplantation...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28602737/identification-and-characterization-of-a-mannose-binding-lectin-from-nile-tilapia-oreochromis-niloticus
#2
Liangliang Mu, Xiaoxue Yin, Jing Liu, Liting Wu, Xia Bian, Yuhong Wang, Jianmin Ye
Mannose-binding lectin (MBL) is a pattern recognition protein that plays an important role in innate immunity capable of activating the lectin pathway of the complement system. In this study, a MBL homologue (OnMBL) was identified from Nile tilapia (Oreochromis niloticus) and characterized at expression and agglutination functional levels. The open reading frame of OnMBL is 687 bp of nucleotide sequence encoding polypeptides of 228 amino acids. The deduced amino acid sequence is highly homology to teleost and similar to mammalian MBL, containing a canonical collagen-like region, a carbohydrate recognition domain and a neck region...
June 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28602683/a-c-type-lectin-nattectin-like-protein-cantc-in-qihe-crucian-carp-carassius-auratus-binding-ability-with-lps-pgn-and-various-bacteria-and-agglutinating-activity-against-bacteria
#3
Li Wang, Jie Zhang, Xianghui Kong, Xianliang Zhao, Chao Pei, Li Li
C-type lectins (CTLs), as the members of pattern-recognition receptors (PRRs), play the significant roles in innate immunity through binding with pathogen-associated molecular patterns (PAMPs) on the surface of microbe. In the present study, a novel CTL, Nattectin-like protein (named as CaNTC), was investigated in Qihe crucian carp Carassius auratus. The full-length cDNA of CaNTC was composed of 776 bp, with a 152 bp 5'-untranslated region (UTR), a 492 bp ORF encoding a 163-aa protein, and a 132 bp 3'-UTR with a polyadenylation signal sequence AATAAA and a poly(A) tail...
June 6, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28536887/ficolin-2-gene-rs7851696-polymorphism-is-associated-with-delayed-graft-function-and-acute-rejection-in-kidney-allograft-recipients
#4
Ewa Dabrowska-Zamojcin, Michal Czerewaty, Damian Malinowski, Maciej Tarnowski, Sylwia Słuczanowska-Głabowska, Leszek Domanski, Krzysztof Safranow, Andrzej Pawlik
Ficolin-2 is an activator of the complement system that acts via the lectin pathway. Complement activation plays a substantial role in the renal injury inherent to kidney transplantation. In this study, we examined the associations between ficolin-2 gene polymorphisms in exon 8 and kidney allograft function. This study comprised 270 Caucasian deceased-donor renal transplant recipients. The following parameters were recorded in each case: delayed graft function (DGF), acute rejection (AR), and chronic allograft dysfunction...
May 23, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28495395/study-of-the-variables-associated-with-local-complement-activation-in-iga-nephropathy
#5
Alfons Segarra-Medrano, Clara Carnicer-Caceres, Naiara Valtierra-Carmeno, Irene Agraz-Pamplona, Natalia Ramos-Terrades, Elías Jatem Escalante, Elena Ostos-Roldan
OBJECTIVES: 1. To identify the variables that are associated with urinary levels of properdin, MBL, C4d, and C5b-9 in patients with idiopathic IgA nephropathy. 2. To analyse whether urinary levels of MBL and/or C4d are useful for identifying the presence of mesangial deposits of C4d/MBL. PATIENTS AND METHOD: A total of 96 patients with IgA nephropathy were studied. Demographic, clinical and biochemical variables were recorded at the time of diagnosis. Renal lesions were quantified using the Oxford classification...
May 8, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28469279/spindle-pole-cohesion-requires-glycosylation-mediated-localization-of-numa
#6
Jérémy Magescas, Lucie Sengmanivong, Amandine Viau, Adeline Mayeux, Tien Dang, Martine Burtin, Ulf J Nilsson, Hakon Leffler, Françoise Poirier, Fabiola Terzi, Delphine Delacour
Glycosylation is critical for the regulation of several cellular processes. One glycosylation pathway, the unusual O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) has been shown to be required for proper mitosis, likely through a subset of proteins that are O-GlcNAcylated during metaphase. As lectins bind glycosylated proteins, we asked if specific lectins interact with mitotic O-GlcNAcylated proteins during metaphase to ensure correct cell division. Galectin-3, a small soluble lectin of the Galectin family, is an excellent candidate, as it has been previously described as a transient centrosomal component in interphase and mitotic epithelial cells...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28407128/the-bittersweet-taste-of-tubulo-interstitial-glycans
#7
REVIEW
Ditmer T Talsma, Mohamed R Daha, Jacob van den Born
Recently, interesting work was published by Farrar et al. [1] showing the interaction of fucosylated glycoproteins on stressed tubular epithelial cells with collectin-11 leading to complement activation via the lectin route of complement. This elegant work stimulated us to evaluate the dark side (bittersweet taste) of tubulo-interstitial glycans in kidney tissue damage. As will be discussed, glycans not only initiate tubular complement activation but also orchestrate tubulo-interstitial leucocyte recruitment and growth factor responses...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28401167/glycopatterns-of-urinary-protein-as-new-potential-diagnosis-indicators-for-diabetic-nephropathy
#8
Hanyu Zhu, Moyan Liu, Hanjie Yu, Xiawei Liu, Yaogang Zhong, Jian Shu, Xinle Fu, Guangyan Cai, Xiangmei Chen, Wenjia Geng, Xiaoli Yang, Minghui Wu, Zheng Li, Dong Zhang
Diabetic nephropathy is a major cause of chronic kidney disease and end-stage kidney disease. However, so little is known about alterations of the glycopatterns in urine with the development of diabetic nephropathy. Presently, we interrogated glycopatterns in urine specimens using a lectin microarray. The results showed that expression levels of Siaα2-6Gal/GalNAc recognized by SNA exhibited significantly increased tendency with the development of diabetic nephropathy; moreover, SNA blotting indicated glycoproteins (90 kDa, 70 kDa, and 40 kDa) in urine may contribute to this alteration...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28394001/pharmacokinetics-biodistribution-and-antitumour-effects-of-sclerotium-rolfsii-lectin-in-mice
#9
S Anupama, Preeti Laha, Mamta Sharma, Kamal Pathak, Sanjay Bane, Arvind D Ingle, Vikram Gota, Rajiv D Kalraiya, Lu-Gang Yu, Jonathan M Rhodes, Bale M Swamy, Shashikala R Inamdar
Sclerotium rolfsii lectin (SRL) is a lectin isolated from the fungus Sclerotium rolfsii and has exquisite binding specificity towards the oncofetal Thomsen-Friedenreich antigen (TF-Ag; Galβ1-3GalNAcα-O-Ser/Thr) and its derivatives. Previous studies have shown that SRL inhibits the proliferation of human colon, breast and ovarian cancer cells in vitro and suppresses tumour growth in mice when introduced intratumourally. The present study assessed the effect of SRL on tumour growth when introduced intraperitoneally in BALB/c nude mice and investigated the pharmacokinetics and biodistribution of SRL in Swiss albino mice...
April 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28387612/development-of-mpmab-1-a-mouse-rat-chimeric-antibody-against-mouse-podoplanin
#10
Shinji Yamada, Mika K Kaneko, Takuro Nakamura, Osamu Ichii, Satoru Konnai, Yukinari Kato
Podoplanin (PDPN), the ligand of C-type lectin-like receptor-2, is used as a lymphatic endothelial marker. We previously established clone PMab-1 of rat IgG2a as a specific monoclonal antibody (mAb) against mouse PDPN. PMab-1 is also very sensitive in immunohistochemical analysis; however, rat mAbs seem to be unfavorable for pathologists because anti-mouse IgG and anti-rabbit IgG are usually used as secondary antibodies in commercially available kits for immunohistochemical analysis. In this study, we develop a mouse-rat chimeric antibody, mPMab-1 of mouse IgG2a, which was derived from rat PMab-1 mAb...
April 7, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28349070/diabetes-is-associated-with-increased-autoreactivity-of-mannan-binding-lectin
#11
Esben Axelgaard, Jakob Appel Østergaard, Steffen Thiel, Troels Krarup Hansen
Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of evolutionary conserved pathogen-associated molecular patterns or to altered self-tissue. Our group have previously shown direct effects of MBL on diabetes-induced kidney damage, and we hypothesized that MBL may cause autoactivation of the complement system via binding to neoepitopes induced by hyperglycemia...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28303635/incident-microalbuminuria-and-complement-factor-mannan-binding-lectin-associated-protein-19-in-people-with-newly-diagnosed-type-1-diabetes
#12
J A Østergaard, S Thiel, I T Hoffmann-Petersen, P Hovind, H-H Parving, L Tarnow, P Rossing, T K Hansen
BACKGROUND: Evidence links the lectin pathway of complement activation to diabetic kidney disease. Upon carbohydrate-recognition by pattern-recognition molecules, eg, mannan-binding lectin (MBL), the MBL-associated serine protease (MASP-2) is activated and initiates the complement cascade. The MASP2 gene encodes MASP-2 and the alternative splice product MBL-associated protein 19 (MAp19). Both MAp19 and MASP-2 circulate in complex with MBL. We tested the hypothesis that MAp19 and MASP-2 concentrations predict the risk of incident microalbuminuria...
March 16, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28278252/complement-inhibition-by-sarcoptes-scabiei-protects-streptococcus-pyogenes-an-in-vitro-study-to-unravel-the-molecular-mechanisms-behind-the-poorly-understood-predilection-of-s-pyogenes-to-infect-mite-induced-skin-lesions
#13
Pearl M Swe, Lindsay D Christian, Hieng C Lu, Kadaba S Sriprakash, Katja Fischer
BACKGROUND: On a global scale scabies is one of the most common dermatological conditions, imposing a considerable economic burden on individuals, communities and health systems. There is substantial epidemiological evidence that in tropical regions scabies is often causing pyoderma and subsequently serious illness due to invasion by opportunistic bacteria. The health burden due to complicated scabies causing cellulitis, bacteraemia and sepsis, heart and kidney diseases in resource-poor communities is extreme...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28262709/a-standardized-method-for-lectin-microarray-based-tissue-glycome-mapping
#14
Xia Zou, Maki Yoshida, Chiaki Nagai-Okatani, Jun Iwaki, Atsushi Matsuda, Binbin Tan, Kozue Hagiwara, Takashi Sato, Yoko Itakura, Erika Noro, Hiroyuki Kaji, Masashi Toyoda, Yan Zhang, Hisashi Narimatsu, Atsushi Kuno
The significance of glycomic profiling has been highlighted by recent findings that structural changes of glycans are observed in many diseases, including cancer. Therefore, glycomic profiling of the whole body (glycome mapping) under different physiopathological states may contribute to the discovery of reliable biomarkers with disease-specific alterations. To achieve this, standardization of high-throughput and in-depth analysis of tissue glycome mapping is needed. However, this is a great challenge due to the lack of analytical methodology for glycans on small amounts of endogenous glycoproteins...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28202166/m1-macrophage-triggered-by-mincle-leads-to-a-deterioration-of-acute-kidney-injury
#15
Tsuyoshi Inoue
In the early stage of acute kidney injury, M1 macrophages are proinflammatory and destructive. In this study, Lv et al. reveal that Mincle (macrophage-inducible C-type lectin, Clec4e) is expressed on M1 macrophages in acute kidney injury, and the kidney is protected in a murine model of cisplatin-induced renal injury by inhibiting Mincle expression on macrophages. Mincle expression is regulated by Toll-like receptor 4/nuclear factor κB signaling, and Mincle maintains the inflammatory phenotype through spleen tyrosine kinase signaling, leading to acute kidney injury...
March 2017: Kidney International
https://www.readbyqxmd.com/read/28168856/biophysical-characterization-and-structural-determination-of-the-potent-cytotoxic-psathyrella-asperospora-lectin
#16
João P Ribeiro, Mohamed Ali Abol Hassan, Razina Rouf, Evelin Tiralongo, Tom W May, Christopher J Day, Anne Imberty, Joe Tiralongo, Annabelle Varrot
A lectin with strong cytotoxic effect on human colon cancer HT29 and monkey kidney VERO cells was recently identified from the Australian indigenous mushroom Psathyrella asperospora and named PAL. We herein present its biochemical and structural analysis using a multidisciplinary approach. Glycan arrays revealed binding preference towards N-acetylglucosamine (GlcNAc) and, to a lesser extent, towards sialic acid (Neu5Ac). Submicromolar and millimolar affinity was measured by surface plasmon resonance for GlcNAc and NeuAc, respectively...
February 7, 2017: Proteins
https://www.readbyqxmd.com/read/28076665/carbohydrate-lectin-interactions-an-unexpected-contribution-to-affinity
#17
Giulio Navarra, Pascal Zihlmann, Roman P Jakob, Katja Stangier, Roland C Preston, Said Rabbani, Martin Smiesko, Bea Wagner, Timm Maier, Beat Ernst
Uropathogenic E. coli exploit PapG-II adhesin for infecting host cells of the kidney; the expression of PapG-II at the tip of bacterial pili correlates with the onset of pyelonephritis in humans, a potentially life-threatening condition. It was envisaged that blocking PapG-II (and thus bacterial adhesion) would provide a viable therapeutic alternative to conventional antibiotic treatment. In our search for potent PapG-II antagonists, we observed an increase in affinity when tetrasaccharide 1, the natural ligand of PapG-II in human kidneys, was elongated to hexasaccharide 2, even though the additional Siaα(2-3)Gal extension is not in direct contact with the lectin...
January 11, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28068663/collectin-kidney-1-plays-an-important-role-in-innate-immunity-against-streptococcus-pneumoniae-infection
#18
Insu Hwang, Kenichiro Mori, Katsuki Ohtani, Yasuyuki Matsuda, Nitai Roy, YounUck Kim, Yasuhiko Suzuki, Nobutaka Wakamiya
Collectins are C-type lectins that are involved in innate immunity as pattern recognition molecules. Recently, collectin kidney 1 (CL-K1) has been discovered, and in vitro studies have shown that CL-K1 binds to microbes and activates the lectin complement pathway. However, in vivo functions of CL-K1 against microbes have not been elucidated. To investigate the biological functions of CL-K1, we generated CL-K1 knockout (CL-K1-/-) mice and then performed a Streptococcus pneumoniae infection analysis. First, we found that recombinant human CL-K1 bound to S...
2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28017903/characterization-and-expression-analysis-of-an-intelectin-gene-from-megalobrama-amblycephala-with-excellent-bacterial-binding-and-agglutination-activity
#19
Zhujin Ding, Xiaoheng Zhao, Qifeng Zhan, Lei Cui, Qianhui Sun, Li Lin, Weimin Wang, Hong Liu
Intelectin is a recently discovered lectin that plays vital roles in the innate immune response, iron metabolism and early embryogenesis. The structure, expression pattern and function of intelectin in mammals and amphibians have been well studied, while not well known in fish. In this study, we cloned a intelectin (MamINTL) gene from blunt snout bream (Megalobrama amblycephala), examined its expression patterns and explored its roles in innate immune response. The MamINTL cDNA encoded 312 amino acids, with a pro-protein of 34 kDa...
February 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28017324/the-pattern-recognition-receptor-mincle-is-essential-for-maintaining-the-m1-macrophage-phenotype-in-acute-renal-inflammation
#20
Lin L Lv, Patrick Ming-Kuen Tang, Chun J Li, Yong K You, Jinhong Li, Xiao-Ru Huang, Jun Ni, Min Feng, Bi C Liu, Hui-Yao Lan
Mincle (macrophage-inducible C-type lectin, Clec4e) is a transmembrane pattern recognition receptor involving the innate immunity, but its role in kidney disease is still unexplored. In the obstructed kidney of the unilateral ureteral obstruction model of renal injury, Mincle was specifically detected in the infiltrating M1 macrophages (CD68(+)iNOS(+) cells) on day one but was rapidly reduced following reduction of M1 macrophages during the progression of kidney injury. Interestingly, Mincle-expressing macrophages were progressively increased in the cisplatin-induced acute kidney injury model, where iNOS expression was detected in the CD68(+) cells following Mincle induction...
December 22, 2016: Kidney International
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