Georgina Gyarmati, Urvi Nikhil Shroff, Anne Riquier-Brison, Dorinne Desposito, Wenjun Ju, Sean D Stocker, Audrey Izuhara, Sachin Deepak, Alejandra Becerra Calderon, James L Burford, Hiroyuki Kadoya, Ju-Young Moon, Yibu Chen, Markus M Rinschen, Nariman Ahmadi, Lester Lau, Daniel Biemesderfer, Aaron W James, Liliana Minichiello, Berislav Zlokovic, Inderbir S Gill, Matthias Kretzler, János Peti-Peterdi
Tissue regeneration is limited in several organs including the kidney, contributing to the high prevalence of kidney disease globally. However, evolutionary and physiological adaptive responses and the presence of renal progenitor cells suggest existing remodeling capacity. This study uncovered endogenous tissue remodeling mechanisms in the kidney that were activated by the loss of body fluid and salt and regulated by a unique niche of a minority renal cell type called the macula densa (MD). Here we identified neuronal differentiation features of MD cells that sense the local and systemic environment, secrete angiogenic, growth and extracellular matrix remodeling factors, cytokines and chemokines, and control resident progenitor cells...
April 10, 2024: Journal of Clinical Investigation