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Stem cell renal

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https://www.readbyqxmd.com/read/29035842/derivation-and-characterization-of-integration-free-ipsc-line-isrm-um51-derived-from-six2-positive-renal-cells-isolated-from-urine-of-an-african-male-expressing-the-cyp2d6-4-17-variant-which-confers-intermediate-drug-metabolizing-activity
#1
Martina Bohndorf, Audrey Ncube, Lucas-Sebastian Spitzhorn, Jürgen Enczmann, Wasco Wruck, James Adjaye
SIX2-positive renal cells isolated from urine from a 51year old male of African origin bearing the CYP2D6 *4/*17 variant were reprogrammed by nucleofection of a combination of two episomal-based plasmids omitting pathway (TGFβ, MEK and GSK3β) inhibition. The induced pluripotent stem cells (iPSCs) were characterized by immunocytochemistry, embryoid body formation, DNA-fingerprinting and karyotype analysis. Comparative transcriptome analyses with human embryonic stem cell lines H1 and H9 revealed a Pearson correlation of 0...
October 7, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29034881/generation-of-induced-pluripotent-stem-cells-derived-from-an-autosomal-dominant-polycystic-kidney-disease-patient-with-a-p-ser1457fs-mutation-in-pkd1
#2
Ching-Ying Huang, Ming-Ching Ho, Jia-Jung Lee, Daw-Yang Hwang, Hui-Wen Ko, Yu-Che Cheng, Yu-Hung Hsu, Huai-En Lu, Hung-Chun Chen, Patrick C H Hsieh
Autosomal dominant polycystic kidney disease is one of the most prevalent forms of inherited cystic kidney disease, and can be characterized by kidney cyst formation and enlargement. Here we report the generation of a Type 1 ADPKD disease iPS cell line, IBMS-iPSC-012-12, which retains the conserved deletion of PKD1, normal karyotype and exhibits the properties of pluripotent stem cells such as ES-like morphology, expression of pluripotent markers and capacity to differentiate into all three germ layers. Our results show that we have successfully generated a patient-specific iPS cell line with a mutation in PKD1 for study of renal disease pathophysiology...
October 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28992100/prenatal-exposure-to-lps-alters-the-intrarenal-ras-in-offspring-which-is-ameliorated-by-adipose-tissue-derived-mesenchymal-stem-cells
#3
Xian-Fei Ding, Mou Sun, Fang-Xia Guan, Li-Na Guo, Yan-Yan Zhang, You-Dong Wan, Xiao-Juan Zhang, Yan-Wu Yu, Shan-Shan Ma, Hai-Mu Yao, Rui Yao, Rui-Fang Zhang, Tong-Wen Sun, Quan-Cheng Kan
BACKGROUND: Prenatal lipopolysaccharide (LPS) exposure causes hypertension in rat offspring through an unknown mechanism. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) in hypertension induced by prenatal LPS exposure and also explored whether adipose tissue-derived mesenchymal stem cells (ADSCs) can ameliorate the effects of prenatal LPS exposure in rat offspring. METHODS: Sixty-four pregnant rats were randomly divided into 4 groups (n = 16 in each), namely, a control group and an LPS group, which were intraperitoneally injected with vehicle and 0...
July 15, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28991252/population-pharmacokinetics-and-pharmacodynamics-of-mycophenolic-acid-using-the-prospective-data-in-patients-undergoing-hematopoietic-stem-cell-transplantation
#4
K Yoshimura, I Yano, T Yamamoto, M Kawanishi, Y Isomoto, A Yonezawa, T Kondo, A Takaori-Kondo, K Matsubara
Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is used to suppress GvHD in patients undergoing hematopoietic stem cell transplantation (HCT). The purpose of this study was to construct a population pharmacokinetic and pharmacodynamic model in HCT patients for individualized MPA therapy. Blood samples were obtained from 49 HCT patients after starting MMF therapy. Population pharmacokinetic and pharmacodynamic parameters were obtained using the program NONMEM. MPA was described via a one-compartment model with a first-order elimination, and 30...
October 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28990105/microrna%C3%A2-24%C3%A2-2-is-associated-with-cell-proliferation-invasion-migration-and-apoptosis-in-renal-cell-carcinoma
#5
Lu Jin, Yifan Li, Liping Nie, Tao He, Jia Hu, Jiaju Liu, Mingwei Chen, Min Shi, Zhimao Jiang, Yaoting Gui, Shangqi Yang, Yongqing Lai
Micro (mi)RNAs are involved in multiple cellular processes, and alterations in miRNA expression have been demonstrated to lead to tumorigenesis. Previous microarray analysis revealed that miRNA (miR)‑24 was downregulated in renal cell carcinoma (RCC). Additionally, miR‑24 has been identified as an oncogene and tumor suppressor in various cancers. The present study assessed the expression levels of two stem‑loops of miR‑24, miR‑24‑1 and miR‑24‑2, in RCC tissues and paired healthy tissues by reverse transcription‑quantitative polymerase chain reaction...
October 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28987247/impact-of-autologous-stem-cell-transplantation-on-blood-pressure-and-renal-function-in-multiple-myeloma-patients
#6
Leah Balsam, Chadi Saad, Camelia Arsene, Joshua Fogel
BACKGROUND: Autologous stem cell transplantation (ASCT) reverses kidney failure in one-third of multiple myeloma (MM) patients, which may lead to blood pressure (BP) improvement. We evaluate the long term impact of ASCT on BP and renal function in MM patients. METHODS: We studied 192 MM patients that underwent ASCT. We compared BP readings and glomerular filtration rate (GFR) at 4 weeks before ASCT, on day of ASCT and post-ASCT at 30, 100 and 180 days. RESULTS: Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) on day of ASCT and at both 30 and 100 days post-ASCT was significantly lower as compared to pre-ASCT SBP and DBP...
2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28986189/prevention-of-cmv-reactivation-in-haploidentical-stem-cell-transplantation
#7
Aimee E Hammerstrom, Lindsey R Lombardi, Sai Ravi Pingali, Gabriela Rondon, Julianne Chen, Denái R Milton, Roy F Chemaly, Richard E Champlin, Alison Gulbis, Stefan O Ciurea
Cytomegalovirus (CMV) infection can increase the morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Due to a higher degree of immunosuppression, haploidentical transplant recipients may be at an increased risk of viral infections, particularly CMV. We retrospectively analyzed 86 haploidentical HCT recipients at our institution, to determine whether a more intensified antiviral strategy would reduce the incidence of CMV reactivation compared with a traditional antiviral prophylaxis regimen...
October 3, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28985199/renal-lineage-cells-as-a-source-for-renal-regeneration
#8
REVIEW
Oren Pleniceanu, Dorit Omer, Orit Harari-Steinberg, Benjamin Dekel
The mammalian kidney is a highly complex organ, composed of various cell types within a unique structural framework. Nonetheless, in recent years, giant leaps in our understanding of nephrogenesis and the origin of new cells in the adult kidney, have resulted in novel routes to regenerate damaged nephrons. While several strategies can be envisioned to achieve this aim, one common theme is the reliance on renal lineage cells, since extra-renal cells, such as bone-marrow derived cells, have been shown to be devoid of renal differentiation capacity...
October 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28978010/the-network-of-dab2ip-mir-138-in-regulating-drug-resistance-of-renal-cell-carcinoma-associated-with-stem-like-phenotypes
#9
Eun-Jin Yun, Jiancheng Zhou, Chun-Jung Lin, Shan Xu, John Santoyo, Elizabeth Hernandez, Chih-Ho Lai, Ho Lin, Dalin He, Jer-Tsong Hsieh
Targeted therapy is a standard of care for metastatic renal cell carcinoma (RCC) but the response rate is not overwhelmed, which only prolongs a short survival of patients due to the onset of therapeutic resistance. Although the mechanisms are not fully understood, the presence of cancer initiating cells (CIC) may underlie the drug resistance. Nevertheless, identifying CIC phenotypes with its biomarkers in RCC appear to be diverse and controversial from many reports. In this study, we took a different approach to focus on the regulatory mechanism in RCC-CIC and unveil DAB2IP-mediated miR-138 expression that plays a critical role in modulating stem-like phenotypes in RCC via targeting the ABC transporter (ABCA13) as well as oncogenic histone methyltransferase EZH2 while down regulation of miR-138 gene expression in RCC is due to epigenetic gene silencing by DNA methyltransferase 1 (DNMT1)...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976282/injectable-co-gels-of-collagen-and-decellularized-vascular-matrix-improve-msc-based-therapy-for-acute-kidney-injury
#10
Shuang Huang, Yajian Li, Xinning Wang, Xin Ma, Xu Zhang
Transplantation of mesenchymal stem cells (MSCs) is promising for treatment of acute kidney injury (AKI), but their therapeutic effects are often limited under normal conditions. In this study, we prepared the co-gels of decellularized vascular matrix and collagen, and investigated whether the co-gels increase the therapeutic potentials of MSCs on AKI. In vitro studies indicated that the co-gels enhanced the paracrine effects of MSCs, and significantly reduced the apoptosis of MSCs under oxidative environments...
October 13, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28972944/delayed-development-of-hemolytic-anemia-with-fragmented-red-blood-cells-and-cardiac-and-renal-impairments-after-high-dose-chemotherapy-and-autologous-hematopoietic-stem-cell-transplantation-for-malignant-lymphoma
#11
Futoshi Iioka, Yusuke Toda, Yuya Nagai, Takashi Akasaka, Daiki Shimomura, Katsuyo Tsuda, Fumihiko Nakamura, Hitoshi Ohno
Among 42 consecutive patients with malignant lymphoma who underwent high-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (AHSCT), 5 developed hemolytic anemia with fragmented red blood cells (HA-FrRBCs) on days 87-125 (median 107) of AHSCT. Nadir Hb levels ranged between 5.0 and 6.4 g/dL with 2.2-5.6% FrRBCs. All patients developed grade ≥3 hypoxia and heart failure, and 4 developed grade ≥3 hypertension. The ejection fraction of the left ventricle assessed by echocardiography was significantly reduced in 3 patients...
October 4, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28954928/human-pluripotent-stem-cell-derived-erythropoietin-producing-cells-ameliorate-renal-anemia-in-mice
#12
Hirofumi Hitomi, Tomoko Kasahara, Naoko Katagiri, Azusa Hoshina, Shin-Ichi Mae, Maki Kotaka, Takafumi Toyohara, Asadur Rahman, Daisuke Nakano, Akira Niwa, Megumu K Saito, Tatsutoshi Nakahata, Akira Nishiyama, Kenji Osafune
The production of erythropoietin (EPO) by the kidneys, a principal hormone for the hematopoietic system, is reduced in patients with chronic kidney disease (CKD), eventually resulting in severe anemia. Although recombinant human EPO treatment improves anemia in patients with CKD, returning to full red blood cell production without fluctuations does not always occur. We established a method to generate EPO-producing cells from human induced pluripotent stem cells (hiPSCs) by modifying previously reported hepatic differentiation protocols...
September 27, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28951984/remote-ischemic-preconditioning-protects-human-neural-stem-cells-from-oxidative-stress
#13
Ayako Motomura, Mikiko Shimizu, Akira Kato, Kazuya Motomura, Akane Yamamichi, Hiroko Koyama, Fumiharu Ohka, Tomohide Nishikawa, Yusuke Nishimura, Masahito Hara, Tetsuya Fukuda, Yasuhiko Bando, Toshihide Nishimura, Toshihiko Wakabayashi, Atsushi Natsume
In previous clinical trials, we showed that remote ischemic preconditioning (rIPC) reduced myocardial damage in children undergoing treatment for congenital heart defects and postoperative renal failure in patients undergoing abdominal aortic aneurysm surgery. In rabbit experiments, pre-treatment with plasma and plasma dialysate (obtained using 15-kDa cut-off dialysis membrane) from donor rabbits subjected to rIPC similarly protected against cardiac infarction. However, the protective substances containing in rIPC plasma have been unknown...
September 26, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28951193/impact-of-toxicity-on-survival-for-older-adult-patients-after-cd34-selected-allogeneic-hematopoietic-stem-cell-transplantation
#14
Gunjan L Shah, Michael Scordo, Satyajit Kosuri, Diego Adrianzen Herrera, Christina Cho, Molly A Maloy, Jimmy Nieves, Sean M Devlin, Taylor Borrill, Dean C Carlow, Scott T Avecilla, Richard C Meagher, Richard J O'Reilly, Ann A Jakubowski, Esperanza B Papadopoulos, Guenther Koehne, Boglarka Gyurkocza, Hugo Castro-Malaspina, Brian C Shaffer, Miguel-Angel Perales, Sergio A Giralt, Roni Tamari
Ex vivo CD 34+ selection prior to allogeneic hematopoietic stem Cell transplantation (allo-HCT) reduces GVHD without increasing relapse, but usually requires myeloablative conditioning. We aimed to identify toxicity patterns in older patients & the association with overall survival (OS) & non-relapse mortality (NRM). We conducted a retrospective analysis of 200 pts who underwent CD34+ selection allo-HCT using the ClinicMACS® system between 2006-2012. All grade 3-5 toxicities by CTCAE v4.0 were collected. Eighty patients ≥ 60yrs with a median age of 64 (range 60-73) were compared to 120 pts <60yrs...
September 22, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28947731/pharmacokinetic-interaction-between-tacrolimus-and-fentanyl-in-patients-receiving-allogeneic-hematopoietic-stem-cell-transplantation
#15
Fumiaki Kitazawa, Shin-Ichi Fuchida, Yoko Kado, Kumi Ueda, Takatoshi Kokufu, Akira Okano, Mayumi Hatsuse, Satoshi Murakami, Yuko Nakayama, Kohji Takara, Chihiro Shimazaki
BACKGROUND Tacrolimus and fentanyl are well-known cytochrome P450 (CYP) 3A4 substrates with a narrow therapeutic range. However, the pharmacokinetic interaction between tacrolimus and fentanyl is unclear. The aim of this study was to determine whether drug interaction exists between tacrolimus and fentanyl. MATERIAL AND METHODS A retrospective study was performed in 6 patients who had received allogeneic hematopoietic stem cell transplantation between April 2010 and March 2015. The patients received continuous intravenous infusion of fentanyl with concomitant use of tacrolimus, and the blood concentrations of tacrolimus were evaluated using fluorescence polarization immunoassay...
September 26, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28944081/renal-volumetry-with-magnetic-resonance-imaging
#16
Rolf H Christensen, Torbjörn Lundgren, Peter Stenvinkel, Torkel B Brismar
BACKGROUND: No gold standard exists for renal volumetry in vivo. PURPOSE: To devise and evaluate segmentation methods on magnetic resonance imaging (MRI) datasets. MATERIAL AND METHODS: Five combinations of MRI pulse sequences and measuring methods were used to measure the renal volumes of five men aged 54-72 years scanned before autologous renal stem cell transplantation and three, six, and 12 months post transplantation. RESULTS: Renal volume did not change after stem cell transplantation...
September 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28941322/stromal-cell-derived-factor-1-mediates-cardiac-allograft-tolerance-induced-by-human-endometrial-regenerative-cell-based-therapy
#17
Xu Lan, Grace Wang, Xiaoxi Xu, Shanzheng Lu, Xiang Li, Baoren Zhang, Ganggang Shi, Yiming Zhao, Caigan Du, Hao Wang
Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells, and their therapeutic potential has been tested in the prevention of renal ischemic reperfusion injury, acute liver injury, ulcerative colitis, and immunosuppression. However, their potential in the induction of transplant tolerance has not been investigated. The present study was undertaken to investigate the efficacy of ERCs in inducing cardiac allograft tolerance and the function of stromal cell-derived factor-1 (SDF-1) in the ERC-mediated immunoregulation...
September 23, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28940837/a-case-of-the-nephrotic-syndrome-in-bone-marrow-transplantation-recipient-histologically-showing-overlapped-glomerular-lesions-of-thrombotic-microangiopathy-and-membranous-nephropathy
#18
Naoko Masuzawa, Ayako Nishimura, Takashi Kitani, Keiichi Tamagaki, Mio Sugitani, Hisao Nagoshi, Junya Kuroda, Eiichi Konishi
Nephrotic syndrome (NS) rarely occurs in post-hematopoietic stem cell transplantation (HSCT) recipients but represents the renal manifestation of graft-versus-host disease (GVHD). Membranous nephropathy (MN) accounts for almost two thirds of post-HSCT NS and is caused by immune complex deposition. Renal thrombotic microangiopathy (TMA) without fulfillment of clinical criteria for TMA has been underreported because of reduced opportunity for histological examination. However, renal TMA has recently been reported in association with GVHD and humoral immunological reactions...
September 20, 2017: Pathology International
https://www.readbyqxmd.com/read/28939456/combination-of-high-dose-methylprednisolone-and-defibrotide-for-veno-occlusive-disease-in-pediatric-hematopoietic-stem-cell-transplant-recipients
#19
Nicholas J Gloude, Sonata Jodele, Ashley Teusink-Cross, Michael Grimley, Stella M Davies, Adam Lane, Kasiani C Myers
Veno-occlusive disease (VOD) is a serious complication of hematopoietic stem cell transplant (HSCT), with high mortality in severe cases, and until recently very limited therapeutic options, consisting largely of supportive care. Defibrotide was recently approved in the United States for the treatment of severe VOD in patients with renal or pulmonary dysfunction following HSCT. Our group previously published on the use of high-dose methylprednisolone (500 mg/m(2)/dose every 12 hours for 6 doses) in patients with VOD showing good success...
September 19, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28933292/endothelial-progenitor-cells-at-the-interface-of-chronic-kidney-disease-from-biology-to-therapeutic-advancement
#20
Giuseppe Coppolino, Valeria Cernaro, Giordano Placida, Giuseppe Leonardi, Giorgio Basile, Davide Bolignano
The 'epidemic' diffusion of chronic kidney disease (CKD) needs the development of new therapeutic approaches to slow down the progression to end-stage renal disease. Endothelial Progenitor Cells (EPCs) are promising tools for the treatment of many human diseases as they promote the repair of damaged tissues. They were also suggested as therapy to repair renal tissue after an injury. Strategies using EPCs to induce a reparative process with functional restoring of a diseased kidney or to delay CKD are of two types: direct stem cells infusion or stimulating endogenous release of EPCs...
September 20, 2017: Current Medicinal Chemistry
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