Lizhuang Shu, Xingyong Li, Zengli Liu, Kangshuai Li, Anda Shi, Yongchang Tang, Liming Zhao, Lingling Huang, Zhiyue Zhang, Dong Zhang, Shaohui Huang, Shuo Lian, Guoli Sheng, Zhangdi Yan, Zongli Zhang, Yunfei Xu
BACKGROUND AIMS: Cholangiocarcinoma(CCA) is a highly lethal malignancy originating from the biliary ducts. Current CCA diagnostic and prognostic assessments cannot satisfy the clinical requirement. Bile detection is rarely performed and herein we aim to estimate the clinical significance of bile liquid biopsy by assessing bile exosomal concentrations and components. APPROACH RESULTS: Exosomes in bile and sera from CCA, pancreatic cancer and common bile duct stone(CBDS) were identified and quantified by TEM, NTA and nanoFCM...
May 5, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases