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Soham Samanta, Senjuti Halder, Gopal Das
Two, cyanine based fluorescent probes L [(E)-2-(4-(diethylamino)-2-hydroxystyryl)-3-ethyl-1,1-dimethyl-1H-benzo[e]indol-3-ium iodide] and L1 [(E)-3-ethyl-1,1-dimethyl-2-(4-nitrostyryl)-1H-benzo[e]indol-3-ium iodide] have been designed and synthesized. Among these two probes; TICT (twisted intramolecular charge transfer) based probe L can preferentially self-assemble to form nanoaggregates. L displayed a selective TURN-ON fluorescence response towards HSA and BSA in ~100% aqueous PBS buffer medium which is noticeable through naked eye whereas L1 failed to sense these albumin proteins...
May 24, 2018: Analytical Chemistry
Qingqing Wu, Mao Mao, Wenlang Liang, Florian J Stadler
Development of thiol-specific fluorescent probes with selectivity in different thiol compounds is more practical and significant than those without that capacity. In this work, a new quinoline-derived fluorophore, hydroxyl-substituted quinoline-benzo[d]oxazole 6 with high fluorescence quantum yield is synthesized and esterified with acrylic acid to afford two fluorescent probes, BQA-1 and BQA-2 for selectively discriminating Cys from Hcys/GSH based on conjugate addition-cyclization mechanism. BQA-1 exhibits a large ratiometric fluorescence response toward Cys in aqueous pH 7...
August 15, 2018: Talanta
Xiaopeng Xu, Zuojia Li, Zhaozhao Bi, Ting Yu, Wei Ma, Kui Feng, Ying Li, Qiang Peng
A novel wide-bandgap copolymer of PBDT-ODZ based on benzo[1,2-b:4,5-b' ]dithiophene (BDT) and 1,3,4-oxadiazole (ODZ) blocks is developed for efficient nonfullerene polymer solar cells (NF-PSCs). PBDT-ODZ exhibits a wide bandgap of 2.12 eV and a low-lying highest occupied molecular orbital (HOMO) level of -5.68 eV, which could match well with the low-bandgap acceptor of 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone)-5,5,11,11-tetrakis(4-hexylthienyl)-dithieno[2,3-d:2',3'-d']-s-indaceno[1,2-b:5,6-b']-dithiophene (ITIC-Th), inducing a good complementary absorption from 300 to 800 nm and a minimal HOMO level offset (0...
May 21, 2018: Advanced Materials
Haijun Bin, Jia Yao, Yankang Yang, Indunil Angunawela, Chenkai Sun, Liang Gao, Long Ye, Beibei Qiu, Lingwei Xue, Chenhui Zhu, Chunhe Yang, Zhi-Guo Zhang, Harald Ade, Yongfang Li
Two medium-bandgap p-type organic small molecules H21 and H22 with an alkylsily-thienyl conjugated side chain on benzo[1,2-b:4,5-b']dithiophene central units are synthesized and used as donors in all-small-molecule organic solar cells (SM-OSCs) with a narrow-bandgap n-type small molecule 2,2'-((2Z,2'Z)-((4,4,9,9-tetrahexyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b']dithiophene-2,7-diyl)bis(methanylylidene))bis(3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile (IDIC) as the acceptor. In comparison to H21 with 3-ethyl rhodanine as the terminal group, H22 with cyanoacetic acid esters as the terminal group shows blueshifted absorption, higher charge-carrier mobility and better 3D charge pathway in blend films...
May 21, 2018: Advanced Materials
Wen-Cheng Chen, Yi Yuan, Ze-Lin Zhu, Zuo-Quan Jiang, Shi-Jian Su, Liang-Sheng Liao, Chun-Sing Lee
Two novel D-σ-A host materials 11,11-bis(9-phenyl-9 H -carbazol-3-yl)-11 H -benzo[4,5]imidazo[1,2- a ]indole (BII-BCz) and 4,4'-(11 H -benzo[4,5]imidazo[1,2- a ]indole-11,11-diyl)bis( N , N -diphenylaniline) (BII-TPA) are synthesized by using the sp3 carbon attached to a newly designed 11 H -benzo[4,5]imidazo[1,2- a ]indole building block to link two electron-donating groups. The resulting materials feature high triplet energy levels, good thermal properties and suitable photophysical properties as universal hosts for full-color phosphorescent organic light-emitting diodes (OLEDs)...
May 7, 2018: Chemical Science
J M Witkin, J L Smith, X Ping, S D Gleason, M M Poe, G Li, X Jin, J Hobbs, J M Schkeryantz, J S McDermott, A I Alatorre, J N Siemian, J W Cramer, D C Airey, K R Methuku, V V N P B Tiruveedhula, T M Jones, J Crawford, M J Krambis, J L Fisher, J M Cook, R Cerne
HZ-166 has previously been characterized as an α2,3-selective GABAA receptor modulator with anticonvulsant, anxiolytic, and anti-nociceptive properties but reduced motor effects. We discovered a series of ester bioisosteres with reduced metabolic liabilities, leading to improved efficacy as anxiolytic-like compounds in rats. In the present study, we evaluated the anticonvulsant effects KRM-II-81 across several rodent models. In some models we also evaluated key structural analogs. KRM-II-81 suppressed hyper-excitation in a network of cultured cortical neurons without affecting the basal neuronal activity...
May 3, 2018: Neuropharmacology
S Viswanathan, V M Berlin Grace
Molecular targeted therapy for specific genes is an emerging research. Retinoic Acid Receptor (RAR-β) is a key tumor suppressor which is found to be lost drastically during much cancer progression. We hence, analyzed the expression level of RAR-β gene during B(a)P induced lung cancer development in mice and studied the lung cancer targeted action of All Trans Retinoic Acid (ATRA) in DOTAP liposomal formulation. The effect of its treatment on lung cancer was determined by histopathological analysis. RAR-β gene expression was assessed by RT-PCR and qPCR...
May 16, 2018: Gene
Synnøve Lofthus, Inger K Almås, Peter Evans, Oliver Pelz, Odd Gunnar Brakstad
Operational planned discharges of produced water (PW) to the marine environment from offshore oil production installations, contain low concentrations of dispersed oil compounds, like polycyclic aromatic hydrocarbons (PAHs) and alkylated phenols (APs). Biotransformation in natural seawater (SW) of naphthalenes/PAHs and phenol/APs in field-collected PW from a North Sea platform was investigated in this biodegradation study. The PW was diluted in SW from a Norwegian fjord, and the biodegradation study was performed in slowly rotating carousels at 13 °C over a period of 62 days...
May 4, 2018: Chemosphere
Diana J Kelm, Jennifer L Ridgeway, Becca L Gas, Monali Mohan, David A Cook, Darlene R Nelson, Roberto P Benzo
PROBLEM: Mindfulness training includes mindfulness meditation, which has been shown to improve both attention and self-awareness. Medical providers in the intensive care unit often deal with difficult situations with strong emotions, life-and-death decisions, and both interpersonal and interprofessional conflicts. The effect of mindfulness meditation training on healthcare providers during acute care tasks such as cardiopulmonary resuscitation remains unknown. Mindfulness meditation has the potential to improve provider well-being and reduce stress in individuals involved in resuscitation teams, which could then translate into better team communication and delivery of care under stress...
May 18, 2018: Teaching and Learning in Medicine
Andrea Savoldelli, Qianli Meng, Roberto Paolesse, Frank R Fronczek, Kevin Malcolm Smith, M Graça Henriques Vicente
A novel route for the synthesis of unsymmetrical benzo-fused BODIPYs is reported using 4,5,6,7-tetrafluoroisoindole as a precursor. The reactivity of the asymmetric 3,5-dibromo benzo-fused BODIPY was investigated under nucleophilic substitution and Pd(0)-catalyzed cross-coupling reaction conditions. In addition to the 3,5-bromines, one α-fluoro group on the benzo-fused ring can also be functionalized, and an unusual homocoupling with formation of a bisBODIPY was observed. This new class of fluorinated BODIPYs could find various applications in medicine and materials...
May 18, 2018: Journal of Organic Chemistry
Ye Fu, Wubin Wang, Xuejing Li, Yanli Liu, Yingying Niu, Bin Zhang, Jisheng Nie, Baolong Pan, Ruisheng Wang, Jin Yang
Benzo [a]pyrene (BaP) have been demonstrated to induce lung cancer risk in humans and many different animal models, with aberrant gene methylation as one of the epigenetic errors; however, the molecular mechanisms remain unclear. Here, we used three types of human lung-derived cells with BaP exposure as a model and attempted to investigate the long non-coding RNA (lncRNA) H19/S-adenosylhomocysteine hydrolase (SAHH) pathway that regulates gene methylation in vitro exposure to BaP. Results showed that compared to the controls, BaP-treated cells H19 expressions were increased in a dose- and time-dependent manner, whereas SAHH protein expressions were decreased...
May 9, 2018: Chemosphere
Olga Vladimirovna Kalugina, Tatiana Alekseevna Mikhailova, Olga Vladimirovna Shergina
Anthropogenic contamination with polycyclic aromatic hydrocarbons (PAH) coming from a powerful aluminum smelter has been estimated by the accumulation of these substances (17 substances: phenanthrene, fluoranthene, pyrene, chrysene, acenaphthylene, acenaphthene, anthracene, fluorene, benz[а]anthracene, benz[b]fluoranthene, benz[k]fluoranthene, benz[а]pyrene, benz[е]pyrene, perylene, indeno[1,2,3-c,d]pyrene, benz[g,h,i]perylene, dibenz[a,h]anthracene) in needles of Scots pine (Pinus sylvestris L.) in the residential areas of Bratsk, East Siberia, Russia...
May 17, 2018: Environmental Science and Pollution Research International
Wei Xu, Gaonan Wang, Xin Xie, Yuanhong Liu
A gold-catalyzed cycloisomerization of ynamide-ynes via a formal dehydro-Diels-Alder reaction has been developed, providing an attractive route to diversely substituted benzo[ b]carbazoles. The reaction likely proceeds via regioselective attack of the pendant alkyne moiety to a keteniminium ion intermediate followed by benzannulation. The method offers several advantages such as high efficiency, mild reaction conditions, and wide functional group tolerance and serves as a highly useful complement to the thermal DDA reactions of ynamide-ynes...
May 16, 2018: Organic Letters
Qinfei Deng, Liping Tan, Yan Xu, Ping Liu, Peipei Sun
A novel visible-light-promoted cascade cyclization reaction for the synthesis of 6-fluoroalkyl 6H-benzo[c]chromenes has been successfully realized, which was initiated by intermolecular radical addition to biaryl vinyl ethers using easily available fluoroalkylated reagents BrCF2CO2Et or 2-bromo-2,2-difluoroamides as the sources of fluorinated radicals, followed by the cyclization onto aromatic ring process. This protocol tolerated a wide range of functional groups and provided the desired products in moderate to good yields...
May 16, 2018: Journal of Organic Chemistry
Chao-Hsuan Chen, Zhi-Wei Lin, Kuan-Min Huang, Hsin-Fei Meng, Ziyi Ge, Hsiao-Wen Zan, Chih-Yu Chang, Yu-Chiang Chao, Sheng-Fu Horng
Interfacial engineering plays an important role in determining the performance and stability of polymer solar cells (PSCs). In this study, we demonstrate thermally stable highly-efficient PSCs by incorporating solution-processed cathode interfacial layer (CIL), including 4,4'-(((methyl(4-sulphonatobutyl)ammonio) bis(propane-3,1-diyl)) bis(dimethyl-ammoniumdiyl)) bis-(butane-1-sulphonate) (MSAPBS) and polyethylenimine (PEI). For PSCs based on blends of poly [4,8-bis (5-(2-ethyl-hexyl) thiophen-2-yl) benzo [1,2-b;4,5-b'] dithiophene-2,6-diyl-alt-(4-(2-ethylhexyl)-3-fluorothieno[3,4-b]thiophene-2-carboxylate-2,6-diyl)] (PBDTTT-EFT) and [6,6]-phenyl C71-butyric acid methyl ester (PC71BM), the maximum power conversion efficiency (PCE) of inverted PSCs reaches 8...
May 16, 2018: ChemSusChem
Mohammad Mahdavi, Arsalan Ashtari, Mahsima Khoshneviszadeh, Sara Ranjbar, Ameneh Dehghani, Tahmineh Akbarzadeh, Bagher Larijani, Mehdi Khoshneviszadeh, Mina Saeedi
A novel series of benzimidazole-1,2,3-triazole hybrids containing substituted benzyl moieties were designed, synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. The results indicated that 2-(4-((1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole (6g) and 2-(4-((1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole (6h) exhibited effective inhibitory activity with IC50 values of 9.42 and 10.34 μM, respectively, comparable to that of kojic acid as the reference drug (IC50 = 9...
May 15, 2018: Chemistry & Biodiversity
Olga Bakulina, Dmitry Dar'in, Mikhail Krasavin
The first example of employing a mixed carboxylic-sulfonic anhydride in reaction with imines is reported. Unlike its well-studied isostere homophthalic anhydride, benzo[c][1,2]oxathiin-3(4H)-one 1,1-dioxide gave no product of a formal [4 + 2] cycloaddition and only followed an alternative reaction pathway toward β-lactams, presumably, via a formal [2 + 2] cycloaddition (a Staudinger-type reaction). Optimized reaction conditions involve the use of triethylamine as a base promoter, which also allows isolating the product β-lactam benzene sulfonic acids as respective triethylammonium salts by conventional column chromatography...
May 16, 2018: Organic & Biomolecular Chemistry
Young-Inn Kim, Seong-Jae Yun, Sung Kwon Kang
The title compound, C26 H20 N2 , was obtained during a search for new π-extended ligands with the potential to generate efficient phosphors with iridium(III) for organic light-emitting devices (OLEDs). The benzoquinoxaline ring system is almost planar (r.m.s. deviation = 0.076 Å). A pseudo-twofold rotation axis runs through the midpoints of the C2-C3 and C9-C10 bonds. The two phenyl rings are twisted relative to the benzoquinoxaline ring system, making dihedral angles of 53.91 (4) and 36.86 (6)°. In the crystal, C-H⋯π (arene) inter-actions link the mol-ecules, but no π-π inter-actions between aromatic rings are observed...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Nico Fleck, Gregor Schnakenburg, Alexander C Filippou, Olav Schiemann
The title compound, a tri-aryl-methanol, C46 H64 OS12 Si3 1 , was synthesized via li-thia-tion of tris-2,2,6,6-tetra-methyl-benzo[1,2- d ;4,5- d ']bis-[1,3]di-thiol-4-yl-methanol, 2 , and electrophilic quenching with tri-methyl-silyl chloride. The current crystal structure reveals information about the reactivity of this compound and compares well with the structure reported for the unsubstituted parent compound 2 [Driesschaert et al. (2012 ▸). Eur. J. Org. Chem. 33 , 6517-6525]. The title compound 1 forms mol-ecular propellers and crystallizes in P [Formula: see text], featuring an unusually long Si-Car bond of 1...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Hemant P Yennawar, Michaela J Buchwalter, Baylee K Colburn, Lee J Silverberg
The syntheses and crystal structures of 2,3-bis-[3-(tri-fluoro-meth-yl)phen-yl]-2,3-di-hydro-4 H -1,3-benzo-thia-zin-4-one (di- m -CF3 ; C22 H13 F6 NOS) ( 1 ) and 2,3-bis-(4-methyl-phen-yl)-2,3-di-hydro-4 H -1,3-benzo-thia-zin-4-one (di- p -CH3 ; C22 H19 NOS) ( 2 ) are reported. Each structure is racemic: the asymmetric unit of 2 consists of two mol-ecules. In both 1 and 2 , the six-membered 1,3-thia-zine ring is close to an envelope conformation with the chiral C atom forming the flap. In 1 , the 2-aryl group is pseudo-equatorial, while in 2 it is pseudo-axial...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
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