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https://www.readbyqxmd.com/read/28812899/synthesis-and-characterization-of-a-boron-nitrogen-boron-zigzag-edged-benzo-fg-tetracene-motif
#1
Michael Fingerle, Cäcilia Maichle-Mössmer, Simon Schundelmeier, Bernd Speiser, Holger F Bettinger
The boron-nitrogen-boron (BNB) zigzag edged benzo[fg]tetracene is accessible from 4-butyl-2,6-diphenylaniline in four steps in good yields. The two mesityl groups stabilize the boron centers toward nucleophilic attack and result in two enantiomeric forms in the solid state. The title compound has a large optical gap, shows blue fluorescence, and is quite resistant toward oxidation and reduction.
August 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/28812058/environmental-pollutants-and-neurodevelopment-review-of-benefits-from-closure-of-a-coal-burning-power-plant-in-tongliang-china
#2
Vrinda Kalia, Frederica Perera, Deliang Tang
Background. Understanding preventable causes of neurodevelopmental disorders is a public health priority. Polycyclic aromatic hydrocarbons (PAH) from combustion of fossil fuel, lead, and mercury are among known neurodevelopmental toxicants. Method. For the first time, we comprehensively review the findings from a study by the Columbia Center for Children's Environmental Health and Chinese partners that followed 2 groups of mother-child pairs, one from 2002 and another from 2005, in Tongliang County, China. Pregnant mothers in the 2 cohorts experienced different exposure to PAH because a local coal-burning power plant was shut down in 2004...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28809576/n-radical-initiated-aminosulfonylation-of-unactivated-c-sp-3-h-bond-through-insertion-of-sulfur-dioxide
#3
Yuewen Li, Runyu Mao, Jie Wu
N-Radical initiated aminosulfonylation of unactivated C(sp(3))-H bond through insertion of sulfur dioxide in the presence of visible light is reported. O-Aryl oximes react with DABCO·(SO2)2 smoothly at room temperature under blue LED irradiation without any metals or photoredox catalysts, generating diverse 5,6-dihydro-4H-1,2-thiazine 1,1-dioxides in good yield. Additionally, this approach can be extended to the synthesis of 1H-benzo[d][1,2]thiazine 2,2-dioxides. During the reaction process, an N-radical is initiated by the treatment of O-aryl oximes with DABCO·(SO2)2 under visible-light irradiation...
August 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28809423/methylthionated-benzo-1-2-b-4-5-b-dithiophenes-a-model-study-to-control-packing-structures-and-molecular-orientation-in-thienoacene-based-organic-semiconductors
#4
Chengyuan Wang, Hiroshi Nakamura, Hiroyoshi Sugino, Kazuo Takimiya
Methylthionation on benzo[1,2-b:4,5-b']dithiophene (BDT) was examined as a promising molecular functionalization strategy to tune the packing structure and molecular orientation on the substrates. β-Methylthionated BDT with a rubrene-like "pitched" π-stacking showed higher mobility than its α-counterpart with a herringbone packing in single-crystal organic field-effect transistors (SC-OFETs).
August 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28808779/optimisation-of-extraction-methods-and-quantification-of-benzo-a-pyrene-and-benz-a-anthracene-in-yerba-mat%C3%A3-tea-by-isotope-dilution-mass-spectrometry
#5
Ee Mei Gui, Ting Lu, Tang Lin Teo, Pui Sze Cheow, Tong Kooi Lee
A gas chromatography-isotope dilution mass spectrometry (GC-IDMS) technique was developed for the quantification of two heavy polyaromatic hydrocarbons (PAHs), benz[a]anthracene and benzo[a]pyrene, in yerba maté tea (maté). The optimisation of two extraction methods, namely liquid-liquid extraction and accelerated solvent extraction, was carried out. Both optimised methods were validated using a certified reference material of fine dust and the results were within the expanded uncertainties at 95% confidence level...
August 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28807506/altered-vulnerability-to-asthma-at-various-levels-of-ambient-benzo-a-pyrene-by-ctla4-stat4-and-cyp2e1-polymorphisms
#6
Hyunok Choi, Nana Tabashidze, Pavel Rossner, Miroslav Dostal, Anna Pastorkova, Sek Won Kong, Hans Gmuender, Radim J Sram
BACKGROUND: Within fossil- and solid-fuel dependent geographic locations, mechanisms of air pollution-induced asthma remains unknown. In particular, sources of greater genetic susceptibility to airborne carcinogen, namely, benzo[a]pyrene (B[a]P) has never been investigated beyond that of a few well known genes. OBJECTIVES: To deepen our understanding on how the genotypic variations within the candidate genes contribute to the variability in the children's susceptibility to ambient B[a]P on doctor-diagnosed asthma...
August 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28805053/heterogeneous-photochemistry-of-agrochemicals-at-leaf-surface-a-case-study-of-plant-activator-acibenzolar-s-methyl
#7
Mohamad Sleiman, Pascal de Sainte Claire, Claire Richard
The photoreactivity of plant activator benzo-(1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH) commonly named acibenzolar-S-methyl was studied on surfaces of glass, paraffinic wax films and apple leaves. Experiments were carried out in a solar simulator using pure and formulated BTH (BION®). Surface photoproducts were identified using liquid chromatography coupled with electrospray ionization and high resolution Orbitrap mass spectrometer, while volatile photoproducts were characterized using an online thermal desorption system coupled to gas chromatography-mass spectrometry (GC-MS)...
August 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28804615/pharmacological-effects-of-a-synthetic-quinoline-a-hybrid-of-tomoxiprole-and-naproxen-against-acute-pain-and-inflammation-in-mice-a-behavioral-and-docking-study
#8
Hossein Hosseinzadeh, Fatemeh Mazaheri, Razieh Ghodsi
OBJECTIVES: In the present study, we investigated the potential anti-nociceptive activity and acute anti-inflammatory effect of a synthetic quinoline compound (2-(4-Methoxyphenyl)benzo[h]quinoline-4-carboxylic acid, QC), possessing structural elements of both naproxen and tomoxiprole drugs. MATERIALS AND METHODS: The anti-nociceptive activity of QC was evaluated using chemical- and thermal-induced nociception models and its acute anti-inflammatory effect was evaluated by xylene-induced ear edema test in mice...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28802573/cytotoxicity-and-cyp1a-inhibition-in-rainbow-trout-liver-rtl-w1-cell-lines-exposed-to-dispersant-corexit-9500-and-its-major-surfactant-components
#9
Subham Dasgupta, Anne E McElroy
As part of a large study examining the toxicity of the Corexit® family of oil spill dispersants on aquatic vertebrates, we examined effects on the liver using an in vitro study using a rainbow trout liver cell line. We exposed RTL-W1 cells to the dispersant Corexit 9500 and its major surfactant components and measured their cytotoxic effects as well as modulation of activity of CYP1A, one of the major enzymes responsible for organic contaminant metabolism. The anionic surfactant DOSS was found to be most cytotoxic with a 24h EC50 of 10mg/L, as compared to 45 to 91mg/L for the non-ionic surfactants, Tween 80 and 85 and Span 80...
August 9, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28801979/germanium-bridged-2-phenylbenzoheteroles-as%C3%A3-luminophores-exhibiting-highly-efficient-solid-state-fluorescence
#10
Masaki Shimizu, Daiki Ryuse, Takumi Kinoshita
[1]Benzogermolo[3,2-b]indoles, [1]benzogermolo[3,2-b]-benzofuran, [1]benzogermolo[3,2-b]benzothiophene, and [1]benzo-germolo[3,2-b]benzothiophene-S,S-dioxide were synthesized from the corresponding 3-bromo-2-(2-bromophenyl)benzoheteroles and characterized. A comparison of the absorption spectra of the Ph2Ge- and Ph2Si-bridged 2-phenylindoles reveals that the Ge-bridge has the effect of slightly widening the HOMO-LUMO energy gap of the bridged 2-phenylindole π-system with regard to the Si-bridged system. Replacement of the indole ring by benzofuran or benzothiophene rings induces blue-shifts in the absorption spectrum, while the absorption spectrum of the benzothiophene-S,S-dioxide derivative was red-shifted with respect to the indole derivative...
August 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28801675/targeting-p-glycoprotein-investigation-of-piperine-analogs-for-overcoming-drug-resistance-in-cancer
#11
Safiulla Basha Syed, Hemant Arya, I-Hsuan Fu, Teng-Kuang Yeh, Latha Periyasamy, Hsing-Pang Hsieh, Mohane Selvaraj Coumar
P-glycoprotein (P-gp) is a drug transporter that effluxes chemotherapeutic drugs and is implicated in the development of resistance of cancer cells to chemotherapeutic drugs. To date, no drug has been approved to inhibit P-gp and restore chemotherapy efficacy. Moreover, majority of the reported inhibitors have high molecular weight and complex structures, making it difficult to understand the basic structural requirement for P-gp inhibition. In this study, two structurally simple, low molecular weight piperine analogs Pip1 and Pip2 were designed and found to better interact with P-gp than piperine in silico...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801633/evaluation-of-novel-factor-xa-inhibitors-from-oxya-chinensis-sinuosa-with-anti-platelet-aggregation-activity
#12
Wonhwa Lee, HeeSeung Lee, Mi-Ae Kim, Joonhyeok Choi, Kyung-Min Kim, Jae Sam Hwang, MinKyun Na, Jong-Sup Bae
The edible grasshopper Oxya chinensis sinuosa is consumed worldwide for its various medicinal effects. The purpose of this study was to investigate potential bioactive antithrombotic and antiplatelet compounds from O. chinensis sinuosa. Five N-acetyldopamine dimers (1-5) were isolated from O. chinensis sinuosa and compounds 1 and 2 were identified as new chemicals with chiral centers at H-2 and H-3 of the benzo-1,4-dioxane structure. Compounds 1-4 were found to have both FXa and platelet aggregation inhibitory activities...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800488/benzo-a-pyrene-induced-a-mitochondria-independent-apoptosis-of-liver-in-juvenile-chinese-rare-minnows-gobiocypris-rarus
#13
Jinmiao Zha, Xiangsheng Hong, Haiou Rao, Lilai Yuan, Zijian Wang, Satyanarayanan Senthil Kumaran
To examine the effects of BaP on tissue apoptosis, laboratory studies were conducted using juvenile Chinese rare minnows (Gobiocypris rarus) exposed to 1, 5, 20, and 80 μg/L of BaP for 28 days. The post-treatment pathological findings in the liver were associated with hepatocyte swelling, karyopyknosis, and karyorrhexis. Moreover, an increase in the goblet cells in the intestine, epithelial hyperplasia of the gills and fusion of gill lamellae were observed. Significant increases in hepatocyte apoptosis using the TUNEL stain were observed in the liver tissue but not in the intestine and gills...
August 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28799217/divergent-ch-annulation-for-multi-fused-n-heterocycles-regio-and-stereospecific-cyclizations-of-n-alkynylindoles
#14
Khyarul Alam, Sung Won Hong, Kyung Hwan Oh, Jin Kyoon Park
N-Alkynylindoles were divergently cyclized for the synthesis of multi-fused N-heterocycles. An ortho-aryl palladium species was added to the -position of an ynamine to generate (Z)-6-alkylidene/benzylidene-6H-isoindolo[2,1-a]indoles, while Pt-catalyzed -addition via -activation gave 5-alkyl/arylindolo[2,1-a]isoquinolines. Double cyclizations using PdCl2 and oxidant afforded bright yellow benzo[7,8]indolizino[2,3,4,5-ija]quinolines, the synthesis of which was also demonstrated in a different synthetic route...
August 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28798528/dosimetry-for-lung-tumorigenesis-induced-by-urethane-4-n-methyl-n-nitrosamino-1-3-pyridyl-1-butanone-nnk-and-benzo-a-pyrene-b-a-p-in-a-jjmsslc-mice
#15
Saeko Onami, Chigusa Okubo, Asuka Iwanaga, Hiroaki Suzuki, Hajime Iida, Yurie Motohashi, Yuki Tomonari, Seiji Otake, Hiroyuki Tsuji, Hiroyuki Yoshimura
Some chemicals are known to be lung carcinogens in rodents. While many studies using two-stage models have administered medium or high doses to mice, few have tested lower doses. The dose dependence of urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P), three well-known lung carcinogens at high doses, has not been sufficiently reported in lower dose ranges. Our study evaluated the tumorigenicity of urethane, NNK, and B[a]P at 26 weeks after a single intraperitoneal administration of each compound within medium to low dose in male and/or female A/JJmsSlc (A/J) mice...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28798500/studying-the-effects-of-two-various-methods-of-composting-on-the-degradation-levels-of-polycyclic-aromatic-hydrocarbons-pahs-in-sewage-sludge
#16
Joanna Poluszyńska, Elżbieta Jarosz-Krzemińska, Edeltrauda Helios-Rybicka
The research comprised of studying the effect composting sewage sludge with sawdust and vermicomposting with earthworm Eisenia fetida has on the degradation of 16 polycyclic aromatic hydrocarbons (PAHs). Raw rural sewage sludge prior composting was more contaminated with PAHs than urban sewage sludge, in both cases exceeding EU cutoff limits of 6 mg/kg established for land application. Dibenzo[a,h]anthracene (DBahAnt), acenaphtylene (Acy) and indeno[1,2,3-c,d]pyrene (IPyr) were predominant in rural sewage sludge, whilst the urban sewage sludge contained the highest concentrations of benzo[b]fluoranthene (BbFl), benzo[k]fluoranthene (BkFl) and indeno[1,2,3-c,d]pyrene (IPyr)...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28795715/spin-dynamics-of-light-induced-charge-separation-in-composites-of-semiconducting-polymers-and-pc60bm-revealed-using-q-band-pulse-epr
#17
E A Lukina, E Suturina, E Reijerse, W Lubitz, L V Kulik
Light-induced processes in composites of semiconducting polymers and fullerene derivatives have been widely studied due to their usage as active layers of organic solar cells. However the process of charge separation under light illumination - the key process of an organic solar cell is not well understood yet. Here we report a Q-band pulse electron paramagnetic resonance study of composites of the fullerene derivative PC60BM ([6,6]-phenyl-C61-butyric acid methyl ester) with different p-type semiconducting polymers regioregular and regiorandom P3HT (poly(3-hexylthiophene-2,5-diyl), MEH-PPV (poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]), PCDTBT (poly[N-9'-heptadecanyl-2,7-carbazole-alt-5,5-(4',7'-di-2-thienyl-2',1',3'-benzothiadiazole)]), PTB7 (poly({4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl}{3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl}))), resulting in a detailed description of the in-phase laser flash-induced electron spin echo (ESE) signal...
August 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28795694/correlating-the-potentiometric-selectivity-of-cyclosporin-based-electrodes-with-binding-patterns-obtained-from-electrospray-ionization-mass-spectrometry
#18
Elsayed M Zahran, Ki-Jung Paeng, Ibrahim H A Badr, David Hume, Bert C Lynn, R Daniel Johnson, Leonidas G Bachas
Electrospray ionization mass spectrometry ESI-MS is a powerful technique for the characterization of macromolecules and their noncovalent binding with guest ions. We herein evaluate the feasibility of using ESI-MS as a screening tool for predicting potentiometric selectivities of ionophores. Ion-selective electrodes based on the cyclic peptide, cyclosporin A, were developed, and their potentiometric selectivity pattern was evaluated. Optimized electrodes demonstrated near-Nernstian slopes with micromolar detection limits toward calcium...
August 10, 2017: Analyst
https://www.readbyqxmd.com/read/28795330/acetylcholinesterase-and-heat-shock-protein-70-response-in-larval-brain-tissue-of-lymantria-dispar-l-lepidoptera-limantriidae-upon-chronic-exposure-to-benzo-a-pyrene
#19
Larisa Ilijin, Marija Mrdaković, Milena Vlahović, Dragana Matić, Anja Gavrilović, Aleksandra Mrkonja, Vesna Perić-Mataruga
The effects of different concentrations of benzo(a)pyrene (BaP) (2, 10, 20, 100, 200, and 2000 ng/g dry food weight) on the activity of acetylcholinesterase (AChE) and concentration of heat-shock protein 70 (hsp70) in fifth instar Lymantria dispar brain tissue were investigated. Inhibition of AChE is a general effect biomarker at the individual level. We observed the most efficient inhibition of this enzyme at medium and high BaP concentrations (20, 100, 200, and 2000 ng/g dry food weight). Western blot analysis revealed the presence of two hsp 70 isoforms, with changed amounts depending on the BaP concentration...
August 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28795279/human-health-risk-assessment-and-pahs-in-a-stretch-of-river-ganges-near-kanpur
#20
Pooja Srivastava, T R Sreekrishnan, A K Nema
The presence of 13 polycyclic aromatic hydrocarbons (PAHs) was measured in a small stretch of river Ganges in Kanpur, using high-performance liquid chromatography equipped with photodiode array detector (HPLC/PDA). Non-carcinogenic risk on human health was calculated in the form of hazardous index. Carcinogenic risk was calculated as chronic daily intake and incremental lifetime cancer risk (ILCR) with the help of monitored PAHs in river water. Due to non-availability of reference dose (RfD) values for all the 13 PAHs, the combined hazardous index for three PAHs was calculated...
August 10, 2017: Environmental Monitoring and Assessment
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