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https://www.readbyqxmd.com/read/28430453/ag-initiated-gem-difluoromethylenation-of-the-nitrogen-center-of-arenediazonium-salts-to-gem-difluoromethylene-azo-compounds
#1
Haizhen Jiang, Yunrong Chen, Bo Chen, Hui Xu, Wen Wan, Hongmei Deng, Kesen Ma, Shaoxiong Wu, Jian Hao
An efficient method for the synthesis of the thermally stable and pharmaceutically important gem-difluoromethylene azo compounds is developed. This protocol achieved gem-difluoromethylenation of the nitrogen center of arenediazonium salts through in situ generated benzo-1,3-diazolic difluoromethylene radical addition to arenediazonium salts under mild Ag-initiated conditions.
April 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28429945/copper-catalyzed-oxidative-cyclization-of-2-amino-azaarenes-with-lignin-models-synthesis-of-3-phenoxy-imidazo-heterocycles
#2
Jian Zhang, Xiunan Lu, Tingyan Li, Shanlu Wang, Guofu Zhong
A catalytic oxidative cyclization of 2-aminopyridines or 2-aminobenzothiazole with 2-phenoxyacetophenones (a kind of lignin platform compounds) was developed, efficiently providing valuable 3-phenoxy imidazo[1,2-a]pyridines or 3-phenoxy benzo[d]imidazo[2,1-b]thiazoles. The reaction was realized under oxygen by simply using inexpensive CuI as the catalyst.
April 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28429811/synthesis-and-structural-characterisation-of-the-aggregates-of-benzo-1-2-chalcogenazole-2-oxides
#3
Peter C Ho, Jamal Rafique, Jiwon Lee, Lucia M Lee, Hilary A Jenkins, James F Britten, Antonio L Braga, Ignacio Vargas-Baca
Iodine oxidation of bis[2-(hydroxyiminomethyl)phenyl] dichalcogenides yields benzo-1,2-chalcogenazole 2-oxides. Annulated derivatives of iso-tellurazole N-oxides spontaneously aggregate into cyclic tetra- and hexamers through TeO chalcogen bonding; the structures of the co-crystals with benzene and CH2Cl2 illustrate the ability of these macrocycles to interact with small guest molecules. The selenium congener crystallizes forming a supramolecular polymer. VT NMR indicates that both compounds aggregate in solution but only at low temperature in the selenium case...
April 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28428138/pregnane-x-receptor-regulates-the-ahr-cyp1a1-pathway-and-protects-liver-cells-from-benzo-%C3%AE-pyrene-induced-dna-damage
#4
Hongmei Cui, Xinsheng Gu, Jingshu Chen, Ying Xie, Sui Ke, Jing Wu, Andrei Golovko, Benjamin Morpurgo, Chunhong Yan, Timothy D Phillips, Wen Xie, Jianyuan Luo, Zhijun Zhou, Yanan Tian
Pregnane X receptor (PXR) plays an important role in protecting cells from mutagenic DNA damages induced by endogenous and exogenous toxicants. This protective function is often attributed to the PXR-regulated metabolic detoxification. Here we report a novel potential mechanism that PXR reduces benzo-[α]-pyrene(BaP)-induced DNA damage through inhibiting the transcriptional activity of aryl hydrocarbon receptor (AhR) which plays a pivotal role in the bioactivation of BaP. We have utilized three well-characterized cell lines, i...
April 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28424000/heavy-metals-and-pahs-in-canned-fish-supplies-on-the-serbian-market
#5
Nikolina J Novakov, Željko A Mihaljev, Brankica D Kartalović, Bojan J Blagojević, Jelana M Petrović, Miroslav A Ćirković, Dragan R Rogan
The aim of this study was to determine the level of heavy metals and PAHs in 57 samples of canned tuna, 25 samples of canned sardines and 16 samples of canned smoked sprouts, collected from supermarkets in Serbia. Heavy metal levels (lead, cadmium, mercury, arsenic, iron, copper and zinc) were determined using an ICP-MS method. Sixteen analyzed PAHs were determined using a GC-MS method. The trace elements in canned fish were in the range (mg kg(-1)) of 0.01-0.28 for lead, 0.003-0.08 for cadmium, 0.007-0.64 for mercury, 0...
April 20, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28422433/rigid-non-fullerene-acceptors-based-on-triptycene-perylene-dye-for-organic-solar-cells
#6
Dong Meng, Huiting Fu, Bingbing Fan, Jianqi Zhang, Yan Li, Yanming Sun, Zhaohui Wang
Three kinds of non-conjugated rigid perylene bisimide (PBI) derivatives based on a triptycene core were designed, synthesized and characterized. The unique three-dimensional (3D) conformation of triptycene could enable formation of polymer with the favorable morphology for organic polymer solar cells (PSCs) by relieving the self-aggregation of rigid PBI units. The low-lying LUMO energy levels of these compounds demonstrated that they are very suitable for using as acceptors in organic solar cells. A higher power conversion efficiency (PCE) of 6...
April 19, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28422328/synthesis-of-benzo-c-silole-derivatives-bearing-a-tetrasubstituted-exocyclic-c-c-double-bond-by-palladium-catalyzed-domino-reactions
#7
Patrick Wagner, Mihaela Gulea, Jean Suffert, Morgan Donnard
We are reporting the synthesis of diversely substituted 2,3-dihydro-benzo[c]siloles via an unprecedented palladium catalyzed domino sequence involving a cyclocarbopalladation of an internal silylalkyne. This reaction proceeds with a complete stereoselectivity to lead to a fully substituted exocyclic C=C double bond. Notably the overall domino sequence appears to be crucial to obtain the desired cyclic vinylsilanes.
April 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28420563/compassion-mindfulness-and-the-happiness-of-healthcare-workers
#8
Roberto P Benzo, Janae L Kirsch, Carlie Nelson
CONTEXT: Decreased well-being of healthcare workers expressed as stress and decreased job satisfaction influences patient safety, patient satisfaction, and cost containment. Self-compassion has garnered recent attention due to its positive association with well-being and happiness. Discovering novel pathways to increase the well-being of healthcare workers is essential. OBJECTIVE: This study sought to explore the influence of self-compassion on employee happiness in healthcare professionals...
February 24, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28418229/assembly-of-a-benzo-fused-bridged-ketone-scaffold-from-1-5-10-enediynes-through-one-pot-ruthenium-catalyzed-cyclization-iodine-mediated-oxidative-ring-expansion
#9
Yoshihiko Yamamoto, Kei-Ichiro Nishimura, Shota Mori, Masatoshi Shibuya
In the presence of a cationic Ru catalyst, 1,6-diynes bearing a terminal styryl moiety underwent [2+2+2] cyclization to produce dehydrobiphenylenes fused with a five-membered ring. Although the cycloadducts were unstable toward purification, their one-pot iodine-mediated ring expansion successfully afforded unprecedented bridged ketone products containing a benzo-fused bicyclo[3.2.1] framework.
April 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28417947/pro-angiogenic-effects-of-low-dose-ethoxidine-in-a-murine-model-of-ischemic-hindlimb-correlation-between-ethoxidine-levels-and-increased-activation-of-the-nitric-oxide-pathway
#10
Nicolas Clere, Kim Hung Thien To, Samuel Legeay, Samuel Bertrand, Jean Jacques Helesbeux, Olivier Duval, Sébastien Faure
Ethoxidine, a benzo[c]phenanthridine derivative, has been identified as a potent inhibitor of topoisomerase I in cancer cell lines. Our group has reported paradoxical properties of ethoxidine in cellular processes leading to angiogenesis on endothelial cells. Because low concentration ethoxidine is able to favor angiogenesis, the present study aimed to investigate the ability of 10(-9) M ethoxidine to modulate neovascularization in a model of mouse hindlimb ischemia. After inducing unilateral hindlimb ischemia, mice were treated for 21 days with glucose 5% or with ethoxidine, to reach plasma concentrations equivalent to 10(-9) M...
April 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28416887/a-preliminary-study-of-pcbs-pahs-pesticides-and-trace-metals-contamination-in-cold-pressed-rapeseed-oils-from-conventional-and-ecological-cultivations
#11
Małgorzata Wroniak, Agnieszka Rękas
The purpose of this study was to investigate the levels of polycyclic aromatic hydrocarbons [benzo(a)anthracene, chrysene, benzo(b)fluoranthene, and benzo(a)pyrene], polychlorinated biphenyls (6 marker and 12 dioxin-like), pesticides (74 compounds) and heavy metals (Pb, Cd, As, Hg, Fe, Cu), in the cold-pressed rapeseed oils from conventional (RC) and ecological cultivations (RE). Similar level of PAHs, PCBs and heavy metals was found in the investigated cold-pressed oils; moreover, no effect of rapeseeds cultivation practice on the level of pesticide residues was found...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28415390/synthesis-spectroscopic-and-dna-binding-ability-of-co-ii-ni-ii-cu-ii-and-zn-ii-complexes-of-schiff-base-ligand-e-1-1h-benzo-d-imidazol-2-yl-methylimino-methyl-naphthalen-2-ol-x-ray-crystal-structure-determination-of-cobalt-ii-complex
#12
Naeema H Yarkandi, Hoda A El-Ghamry, Mohamed Gaber
A novel Schiff base ligand, (E)-1-(((1H-benzo[d]imidazol-2-yl)methylimino)methyl)naphthalen-2-ol (HL), has been designed and synthesized in addition to its metal chelates [Co(L)2]·l2H2O, [Ni(L)Cl·(H2O)2].5H2O, [Cu(L)Cl] and [Zn(L)(CH3COO)]. The structures of the isolated compounds have been confirmed and identified by means of different spectral and physicochemical techniques including CHN analysis, (1)H &(13)C NMR, mass spectral analysis, molar conductivity measurement, UV-Vis, infrared, magnetic moment in addition to TGA technique...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415017/accelerated-solvent-extraction-method-for-the-quantification-of-polycyclic-aromatic-hydrocarbons-in-cocoa-beans-by-gas-chromatography-mass-spectrometry
#13
Renata França Cassimiro Belo, Júlia Pereira Figueiredo, Carolina Mariana Nunes, Rafael Pissinatti, Scheilla Vitorino Carvalho de Souza, Roberto Gonçalves Junqueira
An accelerated solvent extraction (ASE) procedure for use with gas chromatography-mass spectrometry (GC-MS) was optimized for the determination of eight polycyclic aromatic hydrocarbons (PAHs) in cocoa beans. Plackett-Burman and rotatable central composite design (RCCD) indicated that three variables affected the recoveries of PAHs during the extraction and purification steps: agitation time in the second liquid-liquid partition, weight of silica gel in the column, and volume of hexane for PAH elution from the column...
March 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28414378/interference-filter-tilting-to-detect-a-polycyclic-aromatic-hydrocarbon-at-the-second-harmonic-of-wavelength-modulation-frequency
#14
Dmitri Lanevski, Koit Mauring, Eric Tkaczyk
We present a practical implementation of the wavelength-modulation spectroscopy technique with second-harmonic detection for selective detection and concentration measurements of polycyclic aromatic hydrocarbons (PAHs)-common fossil fuel pollutants. The method is based on excitation light wavelength modulation around the maximum of a narrow peak in the absorption spectrum of a PAH and lock-in detection of fluorescence at the second harmonic of the excitation wavelength modulation frequency. A violet LED is used as the excitation source and wavelength modulation is performed via narrowband interference filter tilting...
April 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28413263/intensified-microwave-assisted-n-acylation-procedure-synthesis-and-activity-evaluation-of-trpc3-channel-agonists-with-a-1-3-dihydro-2h-benzo-d-imidazol-2-one-core
#15
Gema Guedes de la Cruz, Barbora Svobodova, Michaela Lichtenegger, Oleksandra Tiapko, Klaus Groschner, Toma Glasnov
Upon controlled microwave heating and using cyanuric chloride as a coupling reagent, an efficient amidation procedure for the synthesis of 1,3-dihydro-2H-benzo[d]imidazol-2-one-based agonists of TRPC3/6 ion channels has been developed. Compared to the few conventional protocols, a drastic reduction in processing time from ca. 2 days down to 10 minutes was achieved accompanied by significantly improved product yields. The robustness of the method was confirmed by 18 additional examples including aromatic, aliphatic, and heterocyclic amines and acids...
April 2017: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry
https://www.readbyqxmd.com/read/28412278/disruption-of-glutamate-neurotransmitter-transmission-is-modulated-by-snap-25-in-benzo-a-pyrene-induced-neurotoxic-effects
#16
Kai Yang, Xuejun Jiang, Qiuping Su, Jing Wang, Chunlin Li, Yinyin Xia, Shuqun Cheng, Qizhong Qin, Xianqing Cao, Chengzhi Chen, Baijie Tu
Benzo[a]pyrene (B[a]P), a ubiquitous chemical contaminant in the environment, is a well-established neurotoxicant to human. However, the molecular mechanisms for B[a]P neurotoxicity are still unclear. In the present study, after treating Sprague-Dawley rats with 0.02, 0.2 and 2.0mg/kg/day B[a]P for 7 weeks [from postnatal day (PND) 5 to PND54], our results showed that B[a]P exposure caused a significant deficits in learning and memory function. By using U87 cells as in vitro model, the significant cytotoxicity and the induction of apoptosis caused by B[a]P were further verified...
April 12, 2017: Toxicology
https://www.readbyqxmd.com/read/28411468/nine-co-localized-cytochrome-p450-genes-of-the-cyp2n-cyp2ad-and-cyp2p-gene-families-in-the-mangrove-killifish-kryptolebias-marmoratus-genome-identification-and-expression-in-response-to-b-%C3%AE-p-bpa-op-and-np
#17
Jayesh Puthumana, Bo-Mi Kim, Chang-Bum Jeong, Duck-Hyun Kim, Hye-Min Kang, Jee-Hyun Jung, Il-Chan Kim, Un-Ki Hwang, Jae-Seong Lee
The CYP2 genes are the largest and most diverse cytochrome P450 (CYP) subfamily in vertebrates. We have identified nine co-localized CYP2 genes (∼55kb) in a new cluster in the genome of the highly resilient ecotoxicological fish model Kryptolebias marmoratus. Molecular characterization, temporal and tissue-specific expression pattern, and response to xenobiotics of these genes were examined. The CYP2 gene clusters were characterized and designated CYP2N22-23, CYP2AD12, and CYP2P16-20. Gene synteny analysis confirmed that the cluster in K...
March 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28407590/exposure-to-lethal-levels-of-benzo-a-pyrene-or-cadmium-trigger-distinct-protein-expression-patterns-in-earthworms-eisenia-fetida
#18
Lihao Zhang, Xiaochen Duan, Nannan He, Xu Chen, Jinli Shi, Weiming Li, Li Xu, Huixin Li
Different pollutants induce distinct toxic responses in earthworms (Eisenia fetida). Here, we used proteomics techniques to compare the responses of E. fetida to exposure to the 10% lethal concentration (14d-LC10) of benzo[a]pyrene (BaP) or cadmium (Cd) in natural red soil (China). BaP exposure markedly induced the expression of oxidation-reduction proteins, whereas Cd exposure mainly induced the expression of proteins involved in transcription- and translation-related processes. Furthermore, calmodulin-binding proteins were differentially expressed upon exposure to different pollutants...
April 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28406647/stereopure-functionalized-benzosultams-via-ruthenium-ii-catalyzed-dynamic-kinetic-resolution-asymmetric-transfer-hydrogenation
#19
Marko Jeran, Andrej Emanuel Cotman, Michel Stephan, Barbara Mohar
A highly diastereo- and enantioselective Ru(II)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation (DKR-ATH) of α-(N-sulfonylimino) and α-(N-sulfonylamino) aryl ketones to 4-hydroxy-benzo-δ- and 3-(α-hydroxy-arylmethyl)-benzo-γ-sultams is presented. By employing enantiopure ansa-Ru[PipSO2DPEN(CH2)4Ph] cat. II with S/C = 10 000 in a HCO2H/Et3N binary mix, up to >99.9% ee and dr >99:1 are obtained with 100% conversion under mild conditions. Application to access the stereopure "structurally simplified TsDPEN" N,N-ligand syn-3-(α-aminobenzyl)-benzo-γ-sultam ("syn-ULTAM") and its structural isomer trans-4-amino-3-phenyl-benzo-δ-sultam (trans-4) is demonstrated...
April 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/28406243/stepwise-cycloaddition-reaction-of-n-phenacylbenzothiazolium-bromides-and-nitroalkenes-for-tetrahydro-dihydro-and-benzo-d-pyrrolo-2-1-b-thiazoles
#20
Gong Jin, Jing Sun, Ren-Yin Yang, Chao-Guo Yan
The triethylamine promoted stepwise 1,3-dipolar cycloaddition reaction of N-phenacylbenzothiazolium bromides with nitroalkenes in ethanol resulted in a mixture of two isomeric tetrahydrobenzo[d]pyrrolo[2,1-b]thiazoles with cis/trans/cis- and all-trans-configurations. More importantly, the corresponding dihydrobenzo[d]pyrrolo[2,1-b]thiazoles can be selectively prepared in refluxing ethanol and the benzo[d]pyrrolo[2,1-b]thiazoles can be obtained in satisfactory yields by sequential dehydrogenation with DDQ as oxidizer...
April 13, 2017: Scientific Reports
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