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Alfonso Maresca, Daniela Vullo, Andrea Scozzafava, Claudiu T Supuran
The gastric pathogen Helicobacter pylori encodes two carbonic anhydrases (CAs, EC, an α- and a β-class one, hpαCA and hpβCA, crucial for its survival in the acidic environment from the stomach. Sulfonamides, strong inhibitors of these enzymes, block the growth of the pathogen, in vitro and in vivo. Here we report the inhibition of the two H. pylori CAs with inorganic and complex anions and other molecules interacting with zinc proteins. hpαCA was inhibited in the low micromolar range by diethyldithiocarbamate, sulfamide, sulfamic acid, phenylboronic acid, and in the submillimolar one by cyanide, cyanate, hydrogen sulfide, divanadate, tellurate, perruthenate, selenocyanide, trithiocarbonate, iminodisulfonate...
April 2013: Journal of Enzyme Inhibition and Medicinal Chemistry
C T Supuran
Zinc-containing enzymes, such as carbonic anhydrases (CAs) and metalloproteases (MPs) play critical functions in bacteria, being involved in various steps of their life cycle, which are important for survival, colonization, acquisition of nutrients for growth and proliferation, facilitation of dissemination, invasion and pathogenicity. The development of resistance to many classes of clinically used antibiotics emphasizes the need of new antibacterial drug targets to be explored. There is a wealth of data regarding bacterial CAs and zinc MPs present in many pathogenic species, such as Neisseria spp...
2012: Current Medicinal Chemistry
Bahar Dindar, Emine Karakuş, Fatih Abasıyanık
The urease enzyme of Helicobacter pylori was isolated from biopsy sample obtained from antrum big curvature cell extracts. A new urea biosensor was prepared by immobilizing urease enzyme isolated from Helicobacter pylori on poly(vinylchloride) (PVC) ammonium membrane electrode by using nonactine as an ammonium ionophore. The effect of pH, buffer concentration, and temperature for the biosensor prepared with urease from H. pylori were obtained as 6.0, 5 mM, and 25 °C, respectively. We also investigated urease concentration, stirring rate, and enzyme immobilization procedures in response to urea of the enzyme electrode...
November 2011: Applied Biochemistry and Biotechnology
V V Tsukanov, E Yu Kupershtein, V N Sharypova
Tenoten reduces anxiety in patients with ulcer disease of the duodenum, promotes pain control, and induces no side effects. Tenoten can be recommended for active use in complex therapy of patients with ulcer disease.
August 2009: Bulletin of Experimental Biology and Medicine
I Higuera-Ciapara, L Félix-Valenzuela, F M Goycoolea
Astaxanthin is a carotenoid widely used in salmonid and crustacean aquaculture to provide the pink color characteristic of that species. This application has been well documented for over two decades and is currently the major market driver for the pigment. Additionally, astaxanthin also plays a key role as an intermediary in reproductive processes. Synthetic astaxanthin dominates the world market but recent interest in natural sources of the pigment has increased substantially. Common sources of natural astaxanthin are the green algae Haematococcus pluvialis, the red yeast, Phaffia rhodozyma, as well as crustacean byproducts...
2006: Critical Reviews in Food Science and Nutrition
S S Kharnas, A V Samokhvalov, R N Lar'kov
No abstract text is available yet for this article.
2000: Khirurgiia
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