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https://www.readbyqxmd.com/read/28449533/can-mathematics-replace-anatomy-to-establish-recommendations-in-lung-cancer-surgery
#1
EDITORIAL
Marc Riquet, Ciprian Pricopi, Antoine Legras, Alex Arame, Alain Badia, Françoise Le Pimpec Barthes
The greater the number of lymph node (LN) sampled (NLNsS) during lung cancer surgery, the lower the risk of underestimating the pN-status and the better the outcome of the pN0-patients due to stage-migration. Thus, regarding LN sampling "to be or not to be", number is the question. Recent studies advocate removing 10 LNs. The most suitable NLNsS is unfortunately impossible to establish by mathematics. A too high NLNsS variability exists, based on anatomy, surgery and pathology. The methodology may vary according to Inter-institutional differences in the surgical approach regarding LN inspection and number sampling...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449507/primary-mediastinal-myelolipoma-a-case-report-and-literature-review
#2
Qingtong Shi, Shu Pan, Yang Bao, Huangxin Fan, Yali Diao
Myelolipoma is a kind of rare benign tumour composed of mature adipocytes and hemopoietic elements, and is most often found in the adrenal glands. Primary mediastinal myelolipoma (PMM) more rarely happens and has no definite symptoms, and mediastinal masses are usually found in chest examination. The patients normally receive a surgical resection and have a favorable prognosis after postoperative pathological diagnosis. Here, we present the case of PMM, which was resected via video-assisted thoracic surgery (VATS), and investigate recent correlative literatures to summarize its etiology, histopathology, differential diagnosis and therapeutic method...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449504/malignant-pheochromocytoma-in-the-anterior-mediastinum-with-sternal-invasion-a-case-report
#3
Mingzhi Song, Kebin Sun, Tian Xia, Lei Zhou, Yangyang Li, Zhe Sun, Yuchi Zhang, Xianbin Zhang, Ran Sun, Bo Chen, Qingwei Tan
Pheochromocytomas are catecholamine-producing neuroendocrine tumors that usually occur in the adrenal medulla or sympathetic paraganglia. Anterior mediastinum involvement with pheochromocytoma is rare and may not present with typical symptoms. Its clinical manifestation may be unclear and a high index of suspicion is required for accurate diagnosis. We report a rare case of pheochromocytoma of the anterior mediastinum in a 51-year-old female. A painful hard mass on the sternum was the only clinical manifestation...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448898/kinematic-gait-pattern-in-children-with-cerebral-palsy-and-leg-length-discrepancy-effects-of-an-extra-sole
#4
Meta N Eek, Roland Zügner, Ingibjörg Stefansdottir, Roy Tranberg
The gait pattern in children with cerebral palsy (CP) often differs from normal, with slow velocity, problem with foot clearance and increased stress on joints. Several factors, such as muscle tone, impaired motor control, muscle contractures, skeletal deformities and leg length discrepancy affect gait. Leg length discrepancy can be treated surgically or with elevation of the shoe on the short leg. The purpose of this study was to examine whether compensating for leg length discrepancy, with elevation of the sole, leads to a change in movement pattern during walking in children with spastic CP...
April 17, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28448861/congenital-unilateral-diaphragmatic-eventration-in-an-adult-a-rare-case-presentation
#5
Johann Paulo S Guzman, Nilo C Delos Santos, Edgar A Baltazar, Allan Troy D Baquir
We present a rare case of 32year old female with congenital diaphragmatic eventeration female presenting in an adult. She had symptoms of intermittent dyspnea and occasional epigastric discomfort. Patient had no previous history of trauma. Physical examination showed bowel sound involving the left hemithorax. Imaging modalities confirmed the diagnosis of a congenital left diaphragmatic eventeration. Patient underwent plication of the diaphragm using the abdominal approach. Intra-operatively, the left diaphragm was attenuated...
April 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28448682/validation-of-the-behavioural-observation-scale-3-for-the-evaluation-of-pain-in-adults
#6
M Frasca, B Burucoa, S Domecq, N Robinson, V Dousset, M Cadenne, F Sztark, M Floccia
BACKGROUND: Many behavioural scales are available to assess pain but none are suitable for a quick evaluation of non-sedated and non-geriatric adults. The Behavioural Observation Scale 3 (BOS-3) is short, composed of five items. This study examined its feasibility and diagnostic performances. METHODS: Adult patients were included from medical and surgical departments of the University Hospital of Bordeaux. In a cross-sectional study, BOS-3 was compared to Numerical Rate Scale (NRS) with communicating patients (CP) and Behavioural Scale for the Elderly Person (ECPA2) with non-communicating patients (NCP)...
April 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28448303/predictability-of-interruptions-during-medication-administration-with-related-behavioral-management-strategies
#7
Maree Johnson, Gabrielle Weidemann, Rebecca Adams, Elizabeth Manias, Tracy Levett-Jones, Vicki Aguilar, Bronwyn Everett
The aim of this qualitative study was to examine the nature of interruptions during medication administration. Focus groups were conducted with medical/surgical nurses (n = 15), critical care nurses (n = 13), and nurse managers/educators/specialists (n = 6). Most interruptions (78%) were predictable. Nurse-adopted strategies included blocking, engaging, mediating, multitasking, and preventing. Educational content was developed that relates behavioral strategies to respond to predictable and unpredictable interruptions...
April 26, 2017: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/28448039/surgical-ablation-assay-for-studying-eye-regeneration-in-planarians
#8
Jacob M Morton, Marwa A Saad, Wendy S Beane
In the study of adult stem cells and regenerative mechanisms, planarian flatworms are a staple in vivo model system. This is due in large part to their abundant pluripotent stem cell population and ability to regenerate all cell and tissue types after injuries that would be catastrophic for most animals. Recently, planarians have gained popularity as a model for eye regeneration. Their ability to regenerate the entire eye (comprised of two tissue types: pigment cells and photoreceptors) allows for the dissection of the mechanisms regulating visual system regeneration...
April 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447965/perspectives-of-using-of-aseptic-drains-for-abdominal-drainage
#9
Merab Kiladze, Paata Tutberidze, Maka Gogoladze, David Tugushi, Ramaz Katsarava, Tsismari Gatenadze
AIM: Aim of the study was to evaluate the effectiveness of using different types of drain tubes to prevent and reduce the drain-associated infection rate of abdominal drainage procedures. MATERIALS AND METHODS: 80 cases of used so called "standard", "coladerm" and "chlorhexidine" drain tubes for abdominal drainage were analysed. "Standard" drain tubes were used 35 times and "coladerm" and "chlorhexidine" tubes - 20 and 25 times respectively. There were adopted in different elective and emergency so called "clean", "potentially contaminated" and "contaminated" abdominal surgical procedures...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28447742/bone-morphogenetic-protein-9-stimulates-callus-formation-in-osteoporotic-rats-during-fracture-healing
#10
Xing Wang, Jun Huang, Fan Huang, Jian-Chun Zong, Xi Tang, Yang Liu, Qiong-Fang Zhang, Yang Wang, Liang Chen, Liang-Jun Yin, Bai-Cheng He, Zhong-Liang Deng
Fracture healing involves the coordinated actions of multiple cytokines. Bone morphogenetic protein 9 (BMP9) is an important factor in bone formation. The present study aimed to investigate the osteogenic potential of bone marrow stem cells (BMSCs) in response to adenoviral (Ad)BMP9, and the early fracture repair properties of AdBMP9 in surgically‑created fractures in osteoporotic rats. Alkaline phosphatase (ALP) activity was assayed and matrix mineralization was examined by Alizarin Red S staining. mRNA and protein expression levels of BMP9, runt‑related transcription factor 2 (RUNX2) and type 1 collagen (COL‑1) were detected in vitro and in vivo...
March 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447605/traumatic-spinal-cord-injury
#11
REVIEW
Christopher S Ahuja, Jefferson R Wilson, Satoshi Nori, Mark R N Kotter, Claudia Druschel, Armin Curt, Michael G Fehlings
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and vocational well-being of patients. The demographic of SCIs is shifting such that an increasing proportion of older individuals are being affected. Pathophysiologically, the initial mechanical trauma (the primary injury) permeabilizes neurons and glia and initiates a secondary injury cascade that leads to progressive cell death and spinal cord damage over the subsequent weeks. Over time, the lesion remodels and is composed of cystic cavitations and a glial scar, both of which potently inhibit regeneration...
April 27, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28447167/success-rate-of-natural-orifice-specimen-extraction-after-laparoscopic-colorectal-resections
#12
S Karagul, C Kayaalp, F Sumer, I Ertugrul, S Kirmizi, A Tardu, M A Yagci
PURPOSE: To date, no data have been available to inform which cases are appropriate for natural orifice specimen extraction (NOSE) after laparoscopic colorectal resections (LCRRs). Our aim was to evaluate the success rate and the factors affecting the failure in patients who were scheduled for NOSE after LCRRs. METHODS: Seventy-two consecutive cases that were intended for NOSE after LCRR were enrolled. The transanal route was always chosen as the first option, and when it failed, the transvaginal route was tried in female patients...
April 26, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28447141/the-iliotibial-band-and-anterolateral-capsule-have-a-combined-attachment-to-the-segond-fracture
#13
Marcio Albers, Humza Shaikh, Elmar Herbst, Kentaro Onishi, Kanto Nagai, Volker Musahl, Freddie H Fu
The purpose of this report was to describe the injury mechanism, surgical findings, and outcomes in a 21-year-old professional female football player who presented with a complete anterior cruciate ligament (ACL) rupture and Segond fracture. Interview and video analysis were performed to elicit the injury mechanism. Clinical examination and imaging revealed a complete ACL tear, Segond fracture, lateral meniscus tear, MCL sprain, and posterolateral corner sprain. Examination under anaesthesia revealed Grade 2 pivot shift and varus/valgus instability...
April 26, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28446938/minimally-invasive-surgery-for-resection-of-ossification-of-the-ligamentum-flavum-in-the-thoracic-spine
#14
Wei Zhao, Chaoxiong Shen, Ranze Cai, Jianfeng Wu, Yuandong Zhuang, Zhaowen Cai, Rui Wang, Chunmei Chen
INTRODUCTION: Thoracic ossification of the ligamentum flavum (TOLF) is a common cause of progressive thoracic myelopathy. Surgical decompression is commonly used to treat TOLF. AIM: To evaluate the clinical outcomes of microsurgical decompression of TOLF via a paraspinal approach, using a percutaneous tubular retractor system. MATERIAL AND METHODS: First, three-dimensional (3D) image reconstruction and printed models were made from thin computed tomography scans for each patient...
2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28446722/urine-mir-21-5p-as-a-potential-non-invasive-biomarker-for-gastric-cancer
#15
Hsiao-Wei Kao, Chao-Yu Pan, Chun-Hung Lai, Chew-Wun Wu, Wen-Liang Fang, Kuo-Hung Huang, Wen-Chang Lin
Many reports have implicated that microRNAs involve in cancer development and progression, such as miR-155 in breast cancers and miR-196 in gastric cancers. Furthermore, microRNAs are more stable than typical protein-coding gene mRNAs in varieties of clinical samples including body fluids. This suggests that they are potentially valuable biomarkers for cancer monitoring. In this study, we have used urine samples of gastric cancer patients to demonstrate the feasibility of urine microRNAs for gastric cancer detection...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28446556/bacteria-driven-peribronchial-lymphoid-neogenesis-in-bronchiectasis-and-cystic-fibrosis
#16
Justine Frija-Masson, Clémence Martin, Lucile Regard, Marie-Noëlle Lothe, Lhousseine Touqui, Aurélie Durand, Bruno Lucas, Diane Damotte, Marco Alifano, Isabelle Fajac, Pierre-Régis Burgel
We aimed to characterise lymphoid neogenesis in bronchiectasis and cystic fibrosis (CF) lungs and to examine the role of bacterial infection.Lymphoid aggregates were examined using immunohistochemical staining and morphometric analysis in surgical lung sections obtained from nonsmokers and patients with bronchiectasis or CF. Sterile, Pseudomonas aeruginosa- or Staphylococcus aureus-coated agarose beads were instilled intratracheally in mice. Kinetics of lymphoid neogenesis and chemokine expression were examined over 14 days...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28446483/spontaneous-ruptured-iliac-artery-aneurysm-causing-acute-secondary-av-fistula
#17
Katherine-Helen Hurndall, Holly Carpenter, Jack Sandeman, Roland Fernandes
A 73-year-old woman presented with a 6-hour history of sudden onset lower abdominal pain. Her comorbidities included chronic obstructive pulmonary disease and hypertension. She was under surveillance for a known thoracoabdominal aneurysm. On presentation, she was hypotensive with a systolic blood pressure of 50 mm Hg and a pulse of 60 beats per minute. On examination, she had a pulsatile mass with bruit in her right lower abdomen. Pedal pulses were palpable in both feet. Blood gas analysis revealed a metabolic acidosis with a pH of 7...
April 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28446133/prevention-and-reversal-of-selenite-induced-cataracts-by-n-acetylcysteine-amide-in-wistar-rats
#18
Yasaswi Maddirala, Shakila Tobwala, Humeyra Karacal, Nuran Ercal
BACKGROUND: The present study sought to evaluate the efficacy of N-acetylcysteine amide (NACA) eye drops in reversing the cataract formation induced by sodium selenite in male Wistar rat pups. METHODS: Forty male Wistar rat pups were randomly divided into a control group, an N-acetylcysteine amide-only group, a sodium selenite-induced cataract group, and a NACA-treated sodium selenite-induced cataract group. Sodium selenite was injected intraperitoneally on postpartum day 10, whereas N-acetylcysteine amide was injected intraperitoneally on postpartum days 9, 11, and 13 in the respective groups...
April 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28446057/comparison-of-survival-outcomes-following-post-surgical-radioactive-iodine-versus-external-beam-radiation-in-stage-iv-differentiated-thyroid-carcinoma
#19
Zao Yang, Jose Flores, Sanford Katz, Cherie-Ann Nathan, Vikas Mehta
<b>Background</b>: There is a lack of well-powered data regarding outcomes in stage IV differentiated thyroid carcinoma (DTC) treated with post-surgical radiation. The objective of this study is to examine survival in patients with stage IV papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) who receive radioactive iodine (RAI), external beam radiation therapy (EBRT), or neither following surgery. <b>Methods</b>: In this retrospective cohort study, data collected from the National Cancer Data Base (NCDB) yielded 11,832 patients with stage IV DTC who underwent primary surgical treatment from 2002 to 2012...
April 27, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28445921/assessment-of-the-synergic-effect-of-immunomodulation-on-nerve-repair-using-multi-parametric-mr-imaging
#20
Chu-Shan Zheng, Xiang Zhang, Yue-Yao Chen, Fang Zhang, Xiao-Hui Duan, Mei-Wei Chen, Lie-Jing Lu, Jun Shen
Introduction:The immune system plays a pivotal role in nerve injury. The aim of this study was to investigate the role of multi-parametric magnetic resonance (MR) imaging in the evaluation of the synergic effect of immunomodulation on nerve regeneration in neurotmesis. METHODS: Rats with sciatic nerve neurotmesis and surgical repair underwent serial multi-parametric MR examinations over an 8 week period after subepineurial microinjection of lipopolysaccharide (LPS) and subsequent subcutaneous injection of FK506 or subepineurial microinjection of LPS or phosphate buffered saline (PBS) alone...
April 26, 2017: Muscle & Nerve
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