Read by QxMD icon Read

special ops

Da Shi, Dmitri Svetlov, Ruben Abagyan, Irina Artsimovitch
Transcription factors from the NusG family bind to the elongating RNA polymerase to enable synthesis of long RNAs in all domains of life. In bacteria, NusG frequently co-exists with specialized paralogs that regulate expression of a small set of targets, many of which encode virulence factors. Escherichia coli RfaH is the exemplar of this regulatory mechanism. In contrast to NusG, which freely binds to RNA polymerase, RfaH exists in a structurally distinct autoinhibitory state in which the RNA polymerase-binding site is buried at the interface between two RfaH domains...
September 6, 2017: Nucleic Acids Research
Patrick Masson, Florian Nachon
Organophosphorus agents (OPs) irreversibly inhibit acetylcholinesterase (AChE) causing a major cholinergic syndrome. The medical counter-measures of OP poisoning have not evolved for the last 30 years with carbamates for pretreatment, pyridinium oximes-based AChE reactivators, antimuscarinic drugs and neuroprotective benzodiazepines for post-exposure treatment. These drugs ensure protection of peripheral nervous system and mitigate acute effects of OP lethal doses. However, they have significant limitations...
August 2017: Journal of Neurochemistry
Johanna Anneser, Tamara Thurn, Gian Domenico Borasio
Introduction Palliative care hospital support teams (HPCTs) provide inpatients from all departments palliative medical support. Seriously ill as well as dying patients, who are being treated in facilities that do not have their own palliative care unit, can benefit from these multi-professional teams just as much as patients who do not (yet) need to be admitted to a palliative care unit. At the end of 2015, 53 HPCTs, which were in accordance with the requirements established in the "Program for HPCTs" by the Bavarian Ministry of Health in 2009, had been approved in Bavaria...
May 15, 2017: Das Gesundheitswesen
Lei Peng, Sheying Dong, Wenbo Wei, Xiaojing Yuan, Tinglin Huang
Electrode materials play a key role in the development of electrochemical sensors, particularly enzyme-based biosensors. Here, a novel NiCo2S4 with reticulated hollow spheres assembled from rod-like structures was prepared by a one-pot solvothermal method and its formation mechanism was discussed. Moreover, comparison of NiCo2S4 materials from different experiment conditions as biosensors was investigated by electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV), and the best one that was reticulated hollow spheres assembled from rod-like structures NiCo2S4 has been successfully employed as a matrix of AChE immobilization for the special structure, superior conductivity and rich reaction active sites...
June 15, 2017: Biosensors & Bioelectronics
Mariusz Cycoń, Zofia Piotrowska-Seget
Pyrethroid insecticides have been used to control pests in agriculture, forestry, horticulture, public health and for indoor home use for more than 20 years. Because pyrethroids were considered to be a safer alternative to organophosphate pesticides (OPs), their applications significantly increased when the use of OPs was banned or limited. Although, pyrethroids have agricultural benefits, their widespread and continuous use is a major problem as they pollute the terrestrial and aquatic environments and affect non-target organisms...
2016: Frontiers in Microbiology
Pauline Jacquet, David Daudé, Janek Bzdrenga, Patrick Masson, Mikael Elias, Eric Chabrière
Organophosphorus chemicals are highly toxic molecules mainly used as pesticides. Some of them are banned warfare nerve agents. These compounds are covalent inhibitors of acetylcholinesterase, a key enzyme in central and peripheral nervous systems. Numerous approaches, including chemical, physical, and biological decontamination, have been considered for developing decontamination methods against organophosphates (OPs). This work is an overview of both validated and emerging strategies for the protection against OP pollution with special attention to the use of decontaminating enzymes...
May 2016: Environmental Science and Pollution Research International
Xiaofei Shi, Rui Chen, Lingling Huo, Lin Zhao, Ru Bai, Dingxin Long, David Y H Pui, Weiqing Rang, Chunying Chen
Indoor air quality has great impact on the human health. An increasing number of studies have shown that printers could release particulate matters and pose adverse effects on indoor air quality. In this study, a thorough investigation was designed to assess the aerosol printer particle total number concentration (TNC) and size distribution in normal office environment, one copy center, and a clean chamber. Particle analyzers, SMPS, OPS, and CPC3007 were used to monitor the total printing process. In normal office environment, 37 laser printers out of all surveyed 55 printers were classified as high particle emitters...
December 2015: Journal of Nanoscience and Nanotechnology
S Lautenschläger
PURPOSE: What is therapeutic nursing? This question is gaining relevance in the context of the billing of services in the DRG system (DRG=Diagnosis-Related Groups), because in paragraph 8-552 of the operations and procedures coding system (OPS), it is explicitly stated that therapeutic care must be carried out by specially trained personnel. To date, empirical results on therapeutic nursing in neurological early rehabilitation are sparse. The objective of the study is to develop a theory of therapeutic care in neurological early rehabilitation...
August 2015: Die Rehabilitation
Antia Rodriguez-Villalon, Bojan Gujas, Ringo van Wijk, Teun Munnik, Christian S Hardtke
Protophloem is a specialized vascular tissue in growing plant organs, such as root meristems. In Arabidopsis mutants with impaired primary root protophloem differentiation, brevis radix (brx) and octopus (ops), meristematic activity and consequently overall root growth are strongly reduced. Second site mutation in the protophloem-specific presumed phosphoinositide 5-phosphatase cotyledon vascular pattern 2 (CVP2), but not in its homolog CVP2-like 1 (CVL1), partially rescues brx defects. Consistent with this finding, CVP2 hyperactivity in a wild-type background recreates a brx phenotype...
April 15, 2015: Development
A Hashemi, F Baghbani-Arani
AIMS: Discrimination of Salmonella strains below the species level is very important to trace the source of outbreaks. To this end molecular typing methods can be successfully applied to routine analysis in nonspecialized laboratories due to their simplicity and speed. Here, the discriminatory ability of four molecular typing methods was investigated in 74 Salmonella enterica isolates. METHODS AND RESULTS: Salmonella strains isolated from human stool, blood, bone marrow, synovial fluid, ascites and urine sources in Iran during the years 2012 and 2013 were differentiated by random amplification of polymorphic DNA (RAPD), enterobacterial repetitive intergenic consensus (ERIC), repetitive extragenic palindromic (REP) and BOX repeat-based (BOXAIR) PCR methods...
June 2015: Journal of Applied Microbiology
Krishna B Clough, Victor Acosta-Marín, Claude Nos, Séverine Alran, Philippe Rouanet, Jean-Rémi Garbay, Sylvia Giard, Jean-Luc Verhaeghe, Gilles Houvenaeghel, Bernard Flipo, Jacques Dauplat, Pierre Hervé Dorangeon, Jean-Marc Classe, Roman Rouzier, Pascal Bonnier
BACKGROUND: The current retrospective study was intended to obtain up-to-date and comprehensive data on surgical practice for breast cancer throughout France, including neoadjuvant chemotherapy (NAC) and the more recent surgical techniques of oncoplastic surgery (OPS). METHODS: In June 2011, e-mail surveys were sent to 33 nationally renowned breast cancer surgeons from French public or private hospitals. The questionnaire focused on all the new cases of breast cancer treated in 2010...
October 2015: Annals of Surgical Oncology
B Sudha Kalyani, Radhika Kunamneni, Megha Wal, Amitabh Ranjan, Ranjan Sen
NusG, a well-conserved protein in all the three forms of life, is involved in transcription elongation and termination, as well as in the process of transcription-translation coupling. The existence of species-specific functional, as well as conformational, divergences in NusG makes it an attractive transcription factor to study, especially if it originates from a pathogen. Here, we report functional and conformational characterizations of the Mycobacterium tuberculosis (Mtb) protein Rv0639 that has been annotated as a homologue of Escherichia coli NusG...
January 2015: Microbiology
Phillip S Hudson, Justin K White, Fiona L Kearns, Milan Hodoscek, Stefan Boresch, H Lee Woodcock
BACKGROUND: Accurately modeling condensed phase processes is one of computation's most difficult challenges. Include the possibility that conformational dynamics may be coupled to chemical reactions, where multiscale (i.e., QM/MM) methods are needed, and this task becomes even more daunting. METHODS: Free energy simulations (i.e., molecular dynamics), multiscale modeling, and reweighting schemes. RESULTS: Herein, we present two new approaches for mitigating the aforementioned challenges...
May 2015: Biochimica et Biophysica Acta
C T B Vivian
BACKGROUND: Assessing incapacity (lack of fitness for work) is a core activity for occupational physicians (OPs). However, it is increasingly thought that biomedical approaches to this assessment are not ideal and there is a need to move to a biopsychosocial paradigm. AIMS: To seek the opinion of practising OPs about long-term fitness to work and assess the degree of consensus within the group surveyed. METHODS: A group of OPs attending a conference considered five case scenarios concerning possible unfitness to work and gave opinions using electronic keypads...
July 2014: Occupational Medicine
M Löhr, R Nitschke, M Schulz, A Wolter, A Hennings, C Wolff-Menzler, J Behrens
BACKGROUND: Against the background of the continuously growing incidence rates of gerontopsychiatric disorders, their economic dimen-sions, and the effects on persons affected as well as their social environments, the present study focuses on an analysis of the services provided in acute psychiatric care settings for patients with dementia. RESULTS are based on secondary data. AIM OF THE STUDY: We aim to compare therapeutic service units of different clusters of occupational groups (physicians/psychologists, nurses/special therapists) for the ICD-10 diagnostic groups F00-F03 and G30 in the years 2010 (starting with July) and 2011...
September 2014: Das Gesundheitswesen
G Kolb, K Breuninger, S Gronemeyer, D van den Heuvel, N Lübke, D Lüttje, A Wittrich, J Wolff
BACKGROUND: Geriatric medicine, as a specialized form of treatment for the elderly, is gaining in importance due to demographic changes. Especially important for geriatric medicine is combining acute care with the need to maintain functionality and participation. This includes prevention of dependency on structured care or chronic disability and handicap by means of rehabilitation. METHODS AND MATERIALS: Ten years ago, the German DRG system tried to incorporate procedures (e...
January 2014: Zeitschrift Für Gerontologie und Geriatrie
S Lautenschläger, C Müller, U Immenschuh, J Muser, J Behrens
BACKGROUND: For some years therapeutic service catalogues have been established in medical rehabilitation which have broadened our previous understanding of nursing actions. Currently, therapeutic nursing plays a prominent role in neurological early rehabilitation because the operations and procedures coding system (OPS) 8-552 within the DRG-System (Diagnosis Related Groups) states that therapeutic nursing must be carried out by specially trained nursing personnel. This requirement leads to inconsistencies in nursing practice and the medical service of the health insurance (MDK) since a definition of therapeutic nursing is lacking...
August 2014: Die Rehabilitation
Sara Mostafalou, Mohammad Abdollahi, Mohammad Ali Eghbal, Nazli Saeedi Kouzehkonani
PURPOSE: Induction of oxidative stress by Organophosphate compounds (OPs) has been previously reported. In the present work, the mechanism of protective effects of N-acetylcysteine as a glutathion (GSH) prodrug against malathion-induced cell toxicity was investigated. In this work, freshly isolated rat hepatocytes were used to determine the effect of NAC on malathion-induced cytotoxicity, formation of reactive oxygen species (ROS) and mitochondrial dysfunction. METHODS: Rat hepatocytes were isolated using collagenase perfusion and then cell viability, mitchondrial membrane potential (MMP) and ROS formation were determined using trypan blue exclusion, Rhodamine 123 fluorescence and fluorogenic probe, 2', 7' -dichlorofluorescin diacetate (DCFH-DA), respectively...
2012: Advanced Pharmaceutical Bulletin
M Psczolla
In Germany there is a clear deficit in the non-operative treatment of chronic and complex diseases and pain disorders in acute care hospitals. Only about 20 % of the treatments are carried out in orthopedic hospitals. Hospitals specialized in manual medicine have therefore formed a working group on non-operative orthopedic manual medicine acute care clinics (ANOA). The ANOA has developed a multimodal assessment procedure called the OPS 8-977 which describes the structure and process quality of multimodal and interdisciplinary diagnosis and treatment of the musculoskeletal system...
October 2013: Der Orthopäde
Luciana Dalcin, Renata C Silva, Fernanda Paulini, Bianca D M Silva, Jairo P Neves, Carolina M Lucci
Even though sheep embryo cryopreservation is a commonly used procedure the survival and pregnancy outcomes can vary greatly. This study investigated whether cryopreservation was causing subtle changes in ultrastructure, mitochondrial activity or cytoskeletal integrity. Sheep embryos were either slow cooled in 1.5 M EG (n = 22), or vitrified in 20% EG + 20% DMSO with 0.5 M sucrose in Open Pulled Straws (OPS) (n = 24). One hour after warming the cryopreserved embryos differed from control embryos in that they had no mitochondrial activity combined with cytoskeletal disorganization and large vesicles...
October 2013: Cryobiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"