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Lauren classification

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https://www.readbyqxmd.com/read/28333795/diagnostic-tests-for-evaluation-of-stillbirth-results-from-the-stillbirth-collaborative-research-network
#1
Jessica M Page, Lauren Christiansen-Lindquist, Vanessa Thorsten, Corette B Parker, Uma M Reddy, Donald J Dudley, George R Saade, Donald Coustan, Carol J Rowland Hogue, Deborah Conway, Radek Bukowski, Halit Pinar, Cara C Heuser, Karen J Gibbins, Robert L Goldenberg, Robert M Silver
OBJECTIVE: To estimate the usefulness of each diagnostic test in the work-up for potential causes of stillbirth. METHODS: A secondary analysis of 512 stillbirths enrolled in the Stillbirth Collaborative Research Network from 2006 to 2008 was performed. The Stillbirth Collaborative Research Network was a multisite, geographically, racially, and ethnically diverse, population-based study of stillbirth in the United States. Participants underwent standardized evaluations that included maternal interview, medical record abstraction, biospecimen collection, fetal autopsy, and placental pathology...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28327158/the-clinicopathological-parameters-and-prognostic-significance-of-her2-expression-in-gastric-cancer-patients-a-meta-analysis-of-literature
#2
REVIEW
Yu-Ying Lei, Jin-Yu Huang, Qiong-Rui Zhao, Nan Jiang, Hui-Mian Xu, Zhen-Ning Wang, Hai-Qing Li, Shi-Bo Zhang, Zhe Sun
BACKGROUND: Human epidermal growth factor receptor-2 (HER2) is regarded as an important and promising target in the treatment of HER2-positive breast cancers. However, the correlation of clinicopathological characteristics and prognostic significance of HER2 overexpression in gastric cancer patients remains unclear. Our aim was to clarify this issue. METHODS: Embase, PubMed, and the Cochrane Library were searched for relevant articles published up to May 2016. Outcomes of interest contained sex, age, tumor size, tumor site, tumor node metastasis (TNM) stage, distant metastasis, lymph node metastasis, Lauren's classification, differentiation grade, lymphovascular invasion, neural invasion, and multivariate analysis data for overall survival...
March 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28286871/semiautomated-workflow-for-clinically-streamlined-glioma-parametric-response-mapping
#3
Lauren Keith, Brian D Ross, Craig J Galbán, Gary D Luker, Stefanie Galbán, Binsheng Zhao, Xiaotao Guo, Thomas L Chenevert, Benjamin A Hoff
Management of glioblastoma multiforme remains a challenging problem despite recent advances in targeted therapies. Timely assessment of therapeutic agents is hindered by the lack of standard quantitative imaging protocols for determining targeted response. Clinical response assessment for brain tumors is determined by volumetric changes assessed at 10 weeks post-treatment initiation. Further, current clinical criteria fail to use advanced quantitative imaging approaches, such as diffusion and perfusion magnetic resonance imaging...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28282907/complications-from-surgeries-related-to-ovarian-cancer-screening
#4
Lauren A Baldwin, Edward J Pavlik, Emma Ueland, Hannah E Brown, Kelsey M Ladd, Bin Huang, Christopher P DeSimone, John R van Nagell, Frederick R Ueland, Rachel W Miller
The aim of this study was to evaluate complications of surgical intervention for participants in the Kentucky Ovarian Cancer Screening Program and compare results to those of the Prostate, Lung, Colorectal and Ovarian Cancer Screening trial. A retrospective database review included 657 patients who underwent surgery for a positive screen in the Kentucky Ovarian Cancer Screening Program from 1988-2014. Data were abstracted from operative reports, discharge summaries, and office notes for 406 patients. Another 142 patients with incomplete records were interviewed by phone...
March 8, 2017: Diagnostics
https://www.readbyqxmd.com/read/28280619/prognostic-value-of-diffuse-versus-intestinal-histotype-in-patients-with-gastric-cancer-a-systematic-review-and-meta-analysis
#5
Fausto Petrelli, Rosa Berenato, Luca Turati, Alessia Mennitto, Francesca Steccanella, Marta Caporale, Pierpaolo Dallera, Filippo de Braud, Ezio Pezzica, Maria Di Bartolomeo, Giovanni Sgroi, Vincenzo Mazzaferro, Filippo Pietrantonio, Sandro Barni
BACKGROUND: There are two distinct types of gastric carcinoma (GC), intestinal, more frequently sporadic and linked to environmental factors, and diffuse (undifferentiated) that is highly metastatic and characterized by rapid disease progression and a poor prognosis. However, there are many conflicting data in the literature concerning the association between histology and prognosis in GC. This meta-analysis was performed to provide demonstration if histology according to Lauren classification is associated with different prognosis in patients with GC...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28277368/diagnostic-tests-for-evaluation-of-stillbirth-stillbirth-collaborative-research-network
#6
Jessica M Page, Lauren Christiansen-Lindquist, Vanessa Thorsten, Corette B Parker, Uma M Reddy, Donald J Dudley, George R Saade, Donald Coustan, Carol J Rowland Hogue, Deborah Conway, Radek Bukowski, Halit Pinar, Cara C Heuser, Karen J Gibbins, Robert L Goldenberg, Robert M Silver
OBJECTIVE: To estimate the usefulness of each diagnostic test in the work-up for potential causes of stillbirth. METHODS: A secondary analysis of 512 stillbirths enrolled in the Stillbirth Collaborative Research Network from 2006 to 2008 was performed. The Stillbirth Collaborative Research Network was a multisite, geographically, racially, and ethnically diverse, population-based study of stillbirth in the United States. Participants underwent standardized evaluations that included maternal interview, medical record abstraction, biospecimen collection, fetal autopsy, and placental pathology...
March 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28276825/perioperative-chemotherapy-for-resectable-gastric-cancer-what-is-the-evidence
#7
Erling A Bringeland, Hans H Wasmuth, Jon E Grønbech
The UK MAGIC trial published in 2006 was the first RCT to identify improved long-term survival rates using preoperative chemotherapy for resectable gastric or gastroesophageal cancer. Overnight, the treatment regimen impacted European guidelines. However, the majority of patients underwent limited lymph node dissection, and analyses of the rates of curative resection, downsizing and downstaging were not by intention to treat, rightfully raising concerns about their validity. For the subset of true gastric cancers, meta-analyses may even question the claims of improved long-term survival rates by present-day regimens...
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28274641/pathways-for-neuroimaging-of-childhood-stroke
#8
REVIEW
David M Mirsky, Lauren A Beslow, Catherine Amlie-Lefond, Pradeep Krishnan, Suzanne Laughlin, Sarah Lee, Laura Lehman, Mubeen Rafay, Dennis Shaw, Michael J Rivkin, Max Wintermark
BACKGROUND: The purpose of this article is to aid practitioners in choosing appropriate neuroimaging for children who present with symptoms that could be caused by stroke. METHODS: The Writing Group members participated in one or more pediatric stroke neuroimaging symposiums hosted by the Stroke Imaging Laboratory for Children housed at the Hospital for Sick Children in Toronto, Ontario, Canada. Through collaboration, literature review, and discussion among child neurologists with expertise diagnosing and treating childhood stroke and pediatric neuroradiologists and neuroradiologists with expertise in pediatric neurovascular disease, suggested imaging protocols are presented for children with suspected stroke syndromes including arterial ischemic stroke, cerebral sinovenous thrombosis, and hemorrhagic stroke...
January 25, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28263666/balancing-for-gross-motor-ability-in-exergaming-between-youth-with-cerebral-palsy-at-gross-motor-function-classification-system-levels-ii-and-iii
#9
Alexander MacIntosh, Lauren Switzer, Hamilton Hernandez, Susan Hwang, Adrian L Jessup Schneider, Daniel Moran, T C Nicolas Graham, Darcy L Fehlings
OBJECTIVE: To test how three custom-built balancing algorithms minimize differences in game success, time above 40% heart rate reserve (HRR), and enjoyment between youth with cerebral palsy (CP) who have different gross motor function capabilities. Youth at Gross Motor Function Classification System (GMFCS) level II (unassisted walking) and level III (mobility aids needed for walking) competed in a cycling-based exercise video game that tested three balancing algorithms. MATERIALS AND METHODS: Three algorithms: a control (generic-balancing [GB]), a constant non-person specific (One-Speed-For-All [OSFA]), and a person-specific (Target-Cadence [TC]) algorithms were built...
March 6, 2017: Games for Health
https://www.readbyqxmd.com/read/28263295/prediction-of-potent-shrnas-with-a-sequential-classification-algorithm
#10
Raphael Pelossof, Lauren Fairchild, Chun-Hao Huang, Christian Widmer, Vipin T Sreedharan, Nishi Sinha, Dan-Yu Lai, Yuanzhe Guan, Prem K Premsrirut, Darjus F Tschaharganeh, Thomas Hoffmann, Vishal Thapar, Qing Xiang, Ralph J Garippa, Gunnar Rätsch, Johannes Zuber, Scott W Lowe, Christina S Leslie, Christof Fellmann
We present SplashRNA, a sequential classifier to predict potent microRNA-based short hairpin RNAs (shRNAs). Trained on published and novel data sets, SplashRNA outperforms previous algorithms and reliably predicts the most efficient shRNAs for a given gene. Combined with an optimized miR-E backbone, >90% of high-scoring SplashRNA predictions trigger >85% protein knockdown when expressed from a single genomic integration. SplashRNA can significantly improve the accuracy of loss-of-function genetics studies and facilitates the generation of compact shRNA libraries...
March 6, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28262585/the-prognostic-and-potentially-predictive-value-of-the-laur%C3%A3-n-classification-in-oesophageal-adenocarcinoma
#11
Rosa T van der Kaaij, Petur Snaebjornsson, Francine E M Voncken, Jolanda M van Dieren, Edwin P M Jansen, Karolina Sikorska, Annemieke Cats, Johanna W van Sandick
AIM: To investigate the histological subtypes of oesophageal adenocarcinoma according to the Laurén classification (intestinal/diffuse/mixed) in relation to tumour response to neoadjuvant treatment, and in relation to patients' survival after potentially curative treatment. METHODS: Data were collected from all oesophageal adenocarcinoma patients who underwent potentially curative treatment in our institute between 1998 and 2014. Treatment consisted of neoadjuvant chemoradiotherapy (36-50 Gy) followed by an oesophagectomy or definitive chemoradiotherapy (50-50...
March 2, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28259588/complication-rates-for-hip-arthroscopy-are-underestimated-a-population-based-study
#12
Jeremy N Truntzer, Daniel J Hoppe, Lauren M Shapiro, Geoffrey D Abrams, Marc Safran
PURPOSE: To identify major and minor complication rates associated with hip arthroscopy from a payer-based national database and compare with the rates reported in the existing literature. METHODS: Patients who underwent hip arthroscopy between 2007 and 2014 were identified using PearlDiver, a publicly available database. Rates of major and minor complications, as well as conversion to total hip arthroscopy (THA), were determined by using Current Procedural Terminology (CPT) and International Classification of Diseases, Ninth Revision (ICD-9), codes...
March 1, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28258421/phenomapping-for-the-identification-of-hypertensive-patients-with-the-myocardial-substrate-for-heart-failure-with-preserved-ejection-fraction
#13
Daniel H Katz, Rahul C Deo, Frank G Aguilar, Senthil Selvaraj, Eva E Martinez, Lauren Beussink-Nelson, Kwang-Youn A Kim, Jie Peng, Marguerite R Irvin, Hemant Tiwari, D C Rao, Donna K Arnett, Sanjiv J Shah
We sought to evaluate whether unbiased machine learning of dense phenotypic data ("phenomapping") could identify distinct hypertension subgroups that are associated with the myocardial substrate (i.e., abnormal cardiac mechanics) for heart failure with preserved ejection fraction (HFpEF). In the HyperGEN study, a population- and family-based study of hypertension, we studied 1273 hypertensive patients utilizing clinical, laboratory, and conventional echocardiographic phenotyping of the study participants. We used machine learning analysis of 47 continuous phenotypic variables to identify mutually exclusive groups constituting a novel classification of hypertension...
March 3, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28255247/prognostic-significance-of-tumor-budding-and-single-cell-invasion-in-gastric-adenocarcinoma
#14
Keying Che, Yang Zhao, Xiao Qu, Zhaofei Pang, Yang Ni, Tiehong Zhang, Jiajun Du, Hongchang Shen
PURPOSE: Gastric carcinoma (GC) is a highly aggressive cancer and one of the leading causes of cancer-related deaths worldwide. Histopathological evaluation pertaining to invasiveness is likely to provide additional information in relation to patient outcome. In this study, we aimed to evaluate the prognostic significance of tumor budding and single cell invasion in gastric adenocarcinoma. MATERIALS AND METHODS: Hematoxylin and eosin-stained slides generated from 296 gastric adenocarcinoma patients with full clinical and pathological and follow-up information were systematically reviewed...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28245840/prognostic-stratification-improvement-by-integrating-id1-id3-igj-gene-expression-signature-and-immunophenotypic-profile-in-adult-patients-with-b-all
#15
Nataly Cruz-Rodriguez, Alba L Combita, Leonardo J Enciso, Lauren F Raney, Paula L Pinzon, Olga C Lozano, Alba M Campos, Niyireth Peñaloza, Julio Solano, Maria V Herrera, Jovanny Zabaleta, Sandra Quijano
BACKGROUND: Survival of adults with B-Acute Lymphoblastic Leukemia requires accurate risk stratification of patients in order to provide the appropriate therapy. Contemporary techniques, using clinical and cytogenetic variables are incomplete for prognosis prediction. METHODS: To improve the classification of adult patients diagnosed with B-ALL into prognosis groups, two strategies were examined and combined: the expression of the ID1/ID3/IGJ gene signature by RT-PCR and the immunophenotypic profile of 19 markers proposed in the EuroFlow protocol by Flow Cytometry in bone marrow samples...
February 28, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28229187/-precursors-of-gastric-cancer-dysplasia-and-adenoma
#16
C Langner
Gastric cancer develops from preneoplastic and early neoplastic precursor lesions. In particular, the intestinal type according to the Lauren classification is driven by chronic inflammation and progresses via a chronic gastritis - atrophy/metaplasia - dysplasia - carcinoma sequence. Staging of the extent of atrophy (OLGA) or intestinal metaplasia (OLGIM) enables risk stratification and determines follow-up investigations according to the management of precancerous conditions and lesions in the stomach (MAPS) international guidelines...
February 22, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28211072/the-diagnosis-of-pancreatic-mucinous-cystic-neoplasm-and-associated-adenocarcinoma-in-males-an-eight-institution-study-of-349-patients-over-15-years
#17
Cecilia G Ethun, Lauren M Postlewait, Mia R McInnis, Nipun Merchant, Alexander Parikh, Kamran Idrees, Chelsea A Isom, William Hawkins, Ryan C Fields, Matthew Strand, Sharon M Weber, Clifford S Cho, Ahmed Salem, Robert C G Martin, Charles R Scoggins, David Bentrem, Hong J Kim, Jacquelyn Carr, Syed A Ahmad, Daniel E Abbott, Gregory Wilson, David A Kooby, Shishir K Maithel
BACKGROUND: Per WHO, 2000 classification, pancreatic mucinous cystic neoplasms (MCN) are defined by presence of ovarian stroma, and are primarily located in the pancreatic body/tail of females. The incidence of MCN and associated malignancy in males, since, standardization of MCN diagnostic-criteria is unknown. METHODS: MCN resections from 2000 to 2014 at eight institutions of the Central-Pancreas-Consortium were included, and divided into early (2000-2007) and late (2008-2014) time-periods...
February 17, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28209473/analysis-of-peripheral-t-cell-lymphoma-diagnostic-workup-in-the-united-states
#18
Eric D Hsi, Steven M Horwitz, Kenneth R Carson, Lauren C Pinter-Brown, Steven T Rosen, Barbara Pro, Massimo Federico, Christian Gisselbrecht, Marc Schwartz, Lisa A Bellm, Mark Acosta, Angela M Collie, Aaron M Gruver, Bartosz J Grzywacz, Samir Turakhia, Andrei R Shustov, Ranjana H Advani, Tatyana Feldman, Mary Jo Lechowicz, Sonali M Smith, Frederick Lansigan, Anil Tulpule, Michael D Craig, John P Greer, Brad S Kahl, Joseph W Leach, Neil Morganstein, Carla Casulo, Steven I Park, Francine M Foss
BACKGROUND: With increased understanding of the unique entities, subtype-specific approaches for peripheral T-cell lymphoma (PTCL) are emerging, and more precise diagnoses are becoming increasingly important. PATIENTS AND METHODS: We analyzed the approach to the histopathologic diagnosis of PTCL using data from the comprehensive oncology measures of peripheral T-cell lymphoma (COMPLETE) study. The COMPLETE trial is a large prospective cohort study of patients with newly diagnosed PTCL in the United States...
January 10, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28206784/adult-age-differences-in-production-and-monitoring-in-dual-list-free-recall
#19
Christopher N Wahlheim, B Hunter Ball, Lauren L Richmond
The present experiment examined adult age differences in the production and monitoring of responses in dual-list free recall. Younger and older adults studied 2 lists of unrelated words and were instructed to recall from List 1, List 2, or List 1 and List 2. An externalized free recall procedure required participants to: (a) report all responses that came to mind while recalling from specific lists, (b) classify responses as correct or incorrect, and (c) provide confidence judgments for their accuracy classifications...
February 16, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28144230/gastrin-and-gastric-cancer
#20
REVIEW
Helge L Waldum, Liv Sagatun, Patricia Mjønes
Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced prevalence of Helicobacter pylori (Hp) infection, which is the most important cause of gastric cancer. There exist many different pathological classifications of gastric carcinomas, but the most useful seems to be the one by Lauren into intestinal and diffuse types since these types seldom transform into the other and also have different epidemiology...
2017: Frontiers in Endocrinology
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