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Lauren classification

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https://www.readbyqxmd.com/read/27901487/hoxb7-overexpression-promotes-cell-proliferation-and-correlates-with-poor-prognosis-in-gastric-cancer-patients-by-inducing-expression-of-both-akt-and-marks
#1
Xujun He, Zhengchuang Liu, Yingjie Xia, Ji Xu, Guocai Lv, Lu Wang, Tonghui Ma, Liping Jiang, Yiping Mou, Xiaoting Jiang, Jie Ma, Zhongkuo Zhao, Haibin Ni, Wenjuan Xu, Guoqing Ru, Dongsheng Huang, Houquan Tao
Increased expression of HOXB7 has been reported to correlate with the progression in many cancers. However, the specific mechanism by which it promotes the evolution of gastric cancer (GC) is poorly understood.In this study, we sought to investigate the role of HOXB7 in GC by assessing HOXB7 expression in patient tissue and its correlation to clinical characteristics. We found that GC tissues showed increased expression of HOXB7 and that the HOXB7 expression was significantly associated with Lauren classification, invasion depth, lymphatic metastasis and poor prognosis, and could serve as an independent prognostic factor...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27871584/a-comparison-of-3-ventilation-strategies-in-children-younger-than-1-year-using-a-proseal-laryngeal-mask-airway-a-randomized-controlled-trial
#2
T Wesley Templeton, Lauren K Hoke, Leah B Templeton, Douglas G Ririe, Danielle M Rose, Yvon F Bryan
STUDY OBJECTIVE: To determine quantitative differences in several routinely measured ventilation parameters using a standardized anesthetic technique and 3 different ventilation modalities in patients younger than 1 year with a ProSeal laryngeal mask airway (PLMA). DESIGN: Randomized prospective study. SETTING: Tertiary care pediatric hospital. PATIENTS: Thirty-nine American Society Anesthesiologists classifications 1 to 2, pediatric patients younger than 1 year...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27861779/change-in-pain-status-in-children-with-cerebral-palsy
#3
Rhandi Christensen, Alexander Macintosh, Lauren Switzer, Darcy Fehlings
AIM: To identify factors associated with a change in pain over time in children with cerebral palsy (CP). METHOD: Pain was assessed at two time-points by physicians and caregiver-rated Health Utilities Index 3 (HUI3) pain scores. RESULTS: One hundred and forty-eight children out of 179 approached from outpatient clinics (83% response; 104 males, 44 females mean age 8y 8mo, range 3y-16y) across all Gross Motor Function Classification System (GMFCS) levels were included...
November 15, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27858920/clinical-risk-assessment-for-gastric-cancer-in-asymptomatic-population-after-a-health-check-up-an-individualized-consideration-of-the-risk-factors
#4
Yoo Mi Park, Jie-Hyun Kim, Su Jung Baik, Jae Jun Park, Young Hoon Youn, Hyojin Park
For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia.The clinical and endoscopic findings of 60,261 adults who underwent gastroduodenoscopy as part of a health check-up were reviewed retrospectively. Subgroup analysis was conducted according to age, sex, cancer stage, and histology based on Lauren classification...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27833855/overexpression-of-klhl23-protein-from-read-through-transcription-of-phospho2-klhl23-in-gastric-cancer-increases-cell-proliferation
#5
Eun-Seok Choi, Hanna Lee, Chang-Hun Lee, Sung-Ho Goh
Gene fusion, as a prototypical pathognomonic mutation, contributes to genome complexity, and the cis-transcription-induced gene fusions generated by read-through transcription of adjacent genes have been found to be important for tumor development. We screened read-through transcription events from stomach adenocarcinoma RNA-seq data and selected three candidates PHOSPHO2-KLHL23, RPL17-C18orf32, and PRR5-ARHGAP8, to assess their biological role in gastric cancer. The expression of all three read-through fusion transcripts was confirmed in gastric cancer cell lines and paired normal/tumor gastric cancer tissues by real-time quantitative reverse transcription polymerase chain reaction and their expression was found to be significantly higher in the tumor (P < 0...
November 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27825567/prevalence-of-rheumatoid-arthritis-in-the-french-west-indies-results-of-the-epppra-study-in-martinique
#6
Lauren Brunier, Marie Bleterry, Sylvie Merle, Christian Derancourt, Katlyn Polomat, Véronique Dehlinger, Christophe Deligny, Georges Jean-Baptiste, Serge Arfi, Rishika Banydeen, Michel De Bandt
OBJECTIVES: Studies suggest that rheumatoid arthritis (RA) is less frequent in African populations. However, no recent precise data exists for Afro-Caribbeans. The EPPPRA project is a prospective epidemiological survey to describe prevalence and clinical aspects of RA in the French West Indies (Martinique, Guadeloupe, French Guiana). METHODS: EPPPRA involved all rheumatologists from the French West Indies who included all patients with a known clinical diagnosis of RA, during a one-year period...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27825359/use-of-a-modified-greenscreen-tool-to-conduct-a-screening-level-comparative-hazard-assessment-of-conventional-silver-and-two-forms-of-nanosilver
#7
Jennifer Sass, Lauren Heine, Nina Hwang
BACKGROUND: Increased concern for potential health and environmental impacts of chemicals, including nanomaterials, in consumer products is driving demand for greater transparency regarding potential risks. Chemical hazard assessment is a powerful tool to inform product design, development and procurement and has been integrated into alternative assessment frameworks. The extent to which assessment methods originally designed for conventionally-sized materials can be used for nanomaterials, which have size-dependent physical and chemical properties, have not been well established...
November 8, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27821817/is-there-a-dose-dependent-effect-of-genetic-susceptibility-loci-for-gastric-cancer-on-prognosis-of-the-patients
#8
Lei Cheng, Li-Xin Qiu, Ming Jia, Fei Zhou, Meng-Yun Wang, Ruo-Xin Zhang, Yajun Yang, Xiaofeng Wang, Jiucun Wang, Li Jin, Qing-Yi Wei
Literature suggests that genetic variants associated with increased susceptibility to gastric cancer (GCa) are mostly located in genes involved in carcinogenesis and possibly tumor progression. Therefore, we hypothesize that high genetic susceptibility is also associated with prognosis of the patients. To test this hypothesis, we selected a total of 42 common genetic variants that were reportedly associated with GCa risk with a high level of evidence obtained from either genome-wide association studies (GWASs) or meta-analyses and performed survival analysis of patients used in a case-control analysis...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27819872/high-throughput-protein-and-mrna-expression-based-classification-of-gastric-cancers-can-identify-clinically-distinct-subtypes-concordant-with-recent-molecular-classifications
#9
Sangjeong Ahn, So-Jeong Lee, Yonugkeum Kim, Ahrong Kim, Nari Shin, Kyung Un Choi, Chang-Hun Lee, Gi Yeong Huh, Kyong-Mee Kim, Namrata Setia, Gregory Y Lauwers, Do Youn Park
Gastric cancers have recently been classified into several types on the basis of molecular characterization, and the new taxonomy has shown to have clinical relevance. However, the technology required for thorough molecular classification is complicated and expensive, currently preventing widespread use. We aimed to reproduce the results of molecular classification using only simple techniques, that is, immunohistochemical analysis and in situ hybridization. We classified a cohort of 349 successive gastric adenocarcinomas into 5 subtypes, on the basis of protein or mRNA expression of MLH1, E-cadherin, p53, and Epstein-Barr virus...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27815484/the-prognostic-value-of-cd44-expression-in-epithelial-mesenchymal-transition-preliminary-data-from-patients-with-gastric-and-esophageal-cancer
#10
Dimitrios Schizas, Demetrios Moris, Prodromos Kanavidis, Adamantios Michalinos, Athanasios Sioulas, Kitty Pavlakis, Anastasios Machairas, Theodoros Liakakos
BACKGROUND: Epithelial-mesenchymal transition is one of the mechanisms that contribute to the aggressiveness of cancer. CD44 antigen is an emerging biomarker that is currently being evaluated in the literature in the frame of epithelial-mesenchymal transition. The aim of this study was to evaluate the expression of CD44 in relation to several clinicopathological parameters in gastric and esophageal carcinomas. MATERIALS AND METHODS: This historical cohort survey was performed on gastric and esophageal tumors obtained from 86 patients who underwent resection from 2003 until 2011...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27809956/the-effectiveness-cost-effectiveness-and-acceptability-of-community-versus-hospital-eye-service-follow-up-for-patients-with-neovascular-age-related-macular-degeneration-with-quiescent-disease-echoes-a-virtual-randomised-balanced-incomplete-block-trial
#11
Barnaby C Reeves, Lauren J Scott, Jodi Taylor, Ruth Hogg, Chris A Rogers, Sarah Wordsworth, Daisy Townsend, Alyson Muldrew, Tunde Peto, Mara Violato, Helen Dakin, Heike Cappel-Porter, Nicola Mills, Dermot O'Reilly, Simon P Harding, Usha Chakravarthy
BACKGROUND: Patients with neovascular age-related macular degeneration (nAMD) usually attend regular reviews, even when the disease is quiescent. Reviews are burdensome to health services, patients and carers. OBJECTIVES: To compare the proportion of correct lesion classifications made by community-based optometrists and ophthalmologists from vignettes of patients; to estimate the cost-effectiveness of community follow-up by optometrists compared with follow-up by ophthalmologists in the Hospital Eye Service (HES); to ascertain views of patients, their representatives, optometrists, ophthalmologists and clinical commissioners on the proposed shared care model...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27787648/cerebrofacial-arteriovenous-metameric-syndrome-cams-a-spectrum-disorder-of-craniofacial-vascular-malformations
#12
Lauren O'Loughlin, Mari L Groves, Neil R Miller, Monica S Pearl
Cerebrofacial arteriovenous metameric syndrome (CAMS) is a recent classification of vascular malformations that encompasses a spectrum of phenotypic expression involving arteriovenous malformations (AVMs) of the cerebral, orbital, and facial region. Recognizing the embryologic basis of CAMS is important for diagnosing other AVMs along the same metameric level. Visual loss is the most common presentation prompting ophthalmologic evaluation followed by neuroimaging. We present two pediatric patients with ipsilateral optic nerve and chiasmal AVMs without cutaneous manifestations, characteristic of CAMS 2...
October 27, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27785051/relationships-between-mgmt-promoter-methylation-and-gastric-cancer-a-meta-analysis
#13
Dan Yu, Tao Cao, Ya-Di Han, Fu-Sheng Huang
A DNA repair enzyme, O6-methylguanine-DNA methyltransferase (MGMT), plays an important role in the development of gastric cancers. However, the role of MGMT promoter methylation in the occurrence of gastric cancer and its relationships with clinicopathologic characteristics has not been fully clarified. Thus, we performed a meta-analysis to evaluate the associations between MGMT promoter methylation and gastric cancer. Electronic databases, including PubMed and Web of Science, were used to systematically search related clinical studies published in English until April 1, 2016...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27765925/receptor-tyrosine-kinase-amplified-gastric-cancer-clinicopathologic-characteristics-and-proposed-screening-algorithm
#14
Cheol Keun Park, Ji Soo Park, Hyo Song Kim, Sun Young Rha, Woo Jin Hyung, Jae-Ho Cheong, Sung Hoon Noh, Sang Kil Lee, Yong Chan Lee, Yong-Min Huh, Hyunki Kim
Although targeted therapy for receptor tyrosine kinases (RTKs) of advanced gastric cancers (AGCs) has been in the spotlight, guidelines for the identification of RTK-amplified gastric cancers (RA-GCs) have not been established. In this study, we investigate clinicopathologic characteristics of RA-GCs and propose a screening algorithm for their identification. We performed immunohistochemistry (IHC) for MLH1, MSH2, PMS2, MSH6, key RTKs (EGFR, HER2, MET), and p53, in situ hybridization for Epstein-Barr virus encoding RNA, and silver in situ hybridization (SISH) for EGFR, HER2, and MET using tissue microarrays of 993 AGCs...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27753660/assessment-of-egfr-and-erbb2-her2-in-gastric-and-gastroesophageal-carcinomas-egfr-amplification-is-associated-with-a-worse-prognosis-in-early-stage-and-well-to-moderately-differentiated-carcinoma
#15
Jia-Bin Liao, Huai-Pao Lee, Hsiao-Ting Fu, Herng-Sheng Lee
Epidermal growth factor receptor 1 (EGFR) and erb-b2 receptor tyrosine kinase 2 (ERBB2/HER2) are frequently dysregulated in human cancers. We analyzed EGFR and ERBB2 status in 105 gastric and gastroesophageal junction carcinoma and their clinicopathologic features. For EGFR, 92 (88%) tumors were scored as 0, 2 (2%) as 1+, 7 (7%) as 2+, and 4 (3%) as 3+ by immunohistochemistry (IHC) and 4 (4%) tumors showed EGFR amplification by fluorescence in situ hybridization (FISH). For ERBB2, 90 (86%) tumors were scored as 0, 4 (4%) as 1+, 6 (6%) as 2+, and 5 (5%) as 3+ by IHC and 12 (12%) showed ERBB2 amplification by FISH...
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27718386/the-burden-of-diabetes-related-foot-disorders-in-community-dwellers-living-in-rural-ecuador-results-of-the-atahualpa-project
#16
Oscar H Del Brutto, Robertino M Mera, Nathan R King, Mauricio Zambrano, Lauren J Sullivan
BACKGROUND/OBJECTIVES: Prevalence of diabetes-related foot disorders (DRFD) in rural areas of developing countries is unknown. The burden of these conditions in Atahualpa, a rural Ecuadorian village, were assessed. METHODS: Using a population-based design, Atahualpa residents aged ≥40 years with diabetes mellitus were identified. Ankle brachial index determinations were used to assess presence of peripheral arterial disease, and the Michigan Neuropathy Screening Instrument was used to estimate peripheral neuropathy...
June 2, 2016: Foot
https://www.readbyqxmd.com/read/27717920/the-effectiveness-of-lower-limb-wearable-technology-for-improving-activity-and-participation-in-adult-stroke-survivors-a-systematic-review
#17
Lauren Powell, Jack Parker, Marrissa Martyn St-James, Susan Mawson
BACKGROUND: With advances in technology, the adoption of wearable devices has become a viable adjunct in poststroke rehabilitation. Regaining ambulation is a top priority for an increasing number of stroke survivors. However, despite an increase in research exploring these devices for lower limb rehabilitation, little is known of the effectiveness. OBJECTIVE: This review aims to assess the effectiveness of lower limb wearable technology for improving activity and participation in adult stroke survivors...
October 7, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27703783/diagnostic-potential-of-structural-neuroimaging-for-depression-from-a-multi-ethnic-community-sample
#18
Anjali Sankar, Tianhao Zhang, Bilwaj Gaonkar, Jimit Doshi, Guray Erus, Sergi G Costafreda, Lauren Marangell, Christos Davatzikos, Cynthia H Y Fu
BACKGROUND: At present, we do not have any biological tests which can contribute towards a diagnosis of depression. Neuroimaging measures have shown some potential as biomarkers for diagnosis. However, participants have generally been from the same ethnic background while the applicability of a biomarker would require replication in individuals of diverse ethnicities. AIMS: We sought to examine the diagnostic potential of the structural neuroanatomy of depression in a sample of a wide ethnic diversity...
July 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703380/evaluation-of-c-met-hgf-and-her-2-expressions-in-gastric-carcinoma-and-their-association-with-other-clinicopathological-factors
#19
Yetkin Yıldız, Cenk Sokmensuer, Suayib Yalcin
BACKGROUND: Met and HER-2 are proto-oncogenes encoding receptor tyrosine kinase c-Met and HER-2, respectively. Hepatocyte growth factor (HGF) is a ligand of c-Met. The frequency of c-Met, HGF, and HER-2 expressions in gastric cancer and their association with other clinicopathological factors have not been fully understood. PATIENTS AND METHODS: Patients with stage 1-4 disease were analyzed. Expressions of c-Met, HGF, and HER-2 were examined using immunohistochemistry...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27687391/comparing-3-ventilation-modalities-by-measuring-several-respiratory-parameters-using-the-proseal-laryngeal-mask-airway-in-children
#20
T Wesley Templeton, Lauren K Hoke, Jill Yaung, Carol A Aschenbrenner, Danielle M Rose, Leah B Templeton, Yvon F Bryan
STUDY OBJECTIVE: To determine quantitative differences in several routinely measured ventilation parameters using a standardized anesthetic technique and 3 different ventilation modalities in pediatric patients with a ProSeal laryngeal mask airway (PLMA). DESIGN: Randomized prospective study. SETTING: Pediatric hospital of a tertiary care academic medical center. PATIENTS: Thirty-three, American Society of Anesthesiologists classification 1-2, pediatric patients (12 months to 5 years)...
November 2016: Journal of Clinical Anesthesia
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