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Lauren classification

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https://www.readbyqxmd.com/read/28229187/-precursors-of-gastric-cancer-dysplasia-and-adenoma
#1
C Langner
Gastric cancer develops from preneoplastic and early neoplastic precursor lesions. In particular, the intestinal type according to the Lauren classification is driven by chronic inflammation and progresses via a chronic gastritis - atrophy/metaplasia - dysplasia - carcinoma sequence. Staging of the extent of atrophy (OLGA) or intestinal metaplasia (OLGIM) enables risk stratification and determines follow-up investigations according to the management of precancerous conditions and lesions in the stomach (MAPS) international guidelines...
February 22, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28211072/the-diagnosis-of-pancreatic-mucinous-cystic-neoplasm-and-associated-adenocarcinoma-in-males-an-eight-institution-study-of-349-patients-over-15-years
#2
Cecilia G Ethun, Lauren M Postlewait, Mia R McInnis, Nipun Merchant, Alexander Parikh, Kamran Idrees, Chelsea A Isom, William Hawkins, Ryan C Fields, Matthew Strand, Sharon M Weber, Clifford S Cho, Ahmed Salem, Robert C G Martin, Charles R Scoggins, David Bentrem, Hong J Kim, Jacquelyn Carr, Syed A Ahmad, Daniel E Abbott, Gregory Wilson, David A Kooby, Shishir K Maithel
BACKGROUND: Per WHO, 2000 classification, pancreatic mucinous cystic neoplasms (MCN) are defined by presence of ovarian stroma, and are primarily located in the pancreatic body/tail of females. The incidence of MCN and associated malignancy in males, since, standardization of MCN diagnostic-criteria is unknown. METHODS: MCN resections from 2000 to 2014 at eight institutions of the Central-Pancreas-Consortium were included, and divided into early (2000-2007) and late (2008-2014) time-periods...
February 17, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28209473/analysis-of-peripheral-t-cell-lymphoma-diagnostic-workup-in-the-united-states
#3
Eric D Hsi, Steven M Horwitz, Kenneth R Carson, Lauren C Pinter-Brown, Steven T Rosen, Barbara Pro, Massimo Federico, Christian Gisselbrecht, Marc Schwartz, Lisa A Bellm, Mark Acosta, Angela M Collie, Aaron M Gruver, Bartosz J Grzywacz, Samir Turakhia, Andrei R Shustov, Ranjana H Advani, Tatyana Feldman, Mary Jo Lechowicz, Sonali M Smith, Frederick Lansigan, Anil Tulpule, Michael D Craig, John P Greer, Brad S Kahl, Joseph W Leach, Neil Morganstein, Carla Casulo, Steven I Park, Francine M Foss
BACKGROUND: With increased understanding of the unique entities, subtype-specific approaches for peripheral T-cell lymphoma (PTCL) are emerging, and more precise diagnoses are becoming increasingly important. PATIENTS AND METHODS: We analyzed the approach to the histopathologic diagnosis of PTCL using data from the comprehensive oncology measures of peripheral T-cell lymphoma (COMPLETE) study. The COMPLETE trial is a large prospective cohort study of patients with newly diagnosed PTCL in the United States...
January 10, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28206784/adult-age-differences-in-production-and-monitoring-in-dual-list-free-recall
#4
Christopher N Wahlheim, B Hunter Ball, Lauren L Richmond
The present experiment examined adult age differences in the production and monitoring of responses in dual-list free recall. Younger and older adults studied 2 lists of unrelated words and were instructed to recall from List 1, List 2, or List 1 and List 2. An externalized free recall procedure required participants to: (a) report all responses that came to mind while recalling from specific lists, (b) classify responses as correct or incorrect, and (c) provide confidence judgments for their accuracy classifications...
February 16, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28144230/gastrin-and-gastric-cancer
#5
REVIEW
Helge L Waldum, Liv Sagatun, Patricia Mjønes
Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced prevalence of Helicobacter pylori (Hp) infection, which is the most important cause of gastric cancer. There exist many different pathological classifications of gastric carcinomas, but the most useful seems to be the one by Lauren into intestinal and diffuse types since these types seldom transform into the other and also have different epidemiology...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28141534/multivariate-time-series-classification-using-the-hidden-unit-logistic-model
#6
Wenjie Pei, Hamdi Dibekliouglu, David M J Tax, Laurens van der Maaten
We present a new model for multivariate time-series classification, called the hidden-unit logistic model (HULM), that uses binary stochastic hidden units to model latent structure in the data. The hidden units are connected in a chain structure that models temporal dependencies in the data. Compared with the prior models for time-series classification such as the hidden conditional random field, our model can model very complex decision boundaries, because the number of latent states grows exponentially with the number of hidden units...
January 27, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28130640/expansion-of-the-classification-of-ftld-tdp-distinct-pathology-associated-with-rapidly-progressive-frontotemporal-degeneration
#7
Edward B Lee, Sílvia Porta, G Michael Baer, Yan Xu, EunRan Suh, Linda K Kwong, Lauren Elman, Murray Grossman, Virginia M-Y Lee, David J Irwin, Vivianna M Van Deerlin, John Q Trojanowski
Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) can typically be categorized into one of four distinct histopathologic patterns of TDP-43 pathology, types A to D. The strength of this histopathologic classification lies in the association between FTLD-TDP subtypes and various clinical and genetic features of disease. Seven cases of FTLD-TDP were identified here which were difficult to classify based on existing pathologic criteria. Distinct features common to these cases included TDP-43 aggregates over a wide neuroanatomic distribution comprised of granulofilamentous neuronal inclusions, abundant grains, and oligodendroglial inclusions...
January 27, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28130240/locust-a-custom-sequence-locus-typer-for-classifying-microbial-isolates
#8
Lauren M Brinkac, Erin Beck, Jason Inman, Pratap Venepally, Derrick E Fouts, Granger Sutton
: LOCUST is a custom sequence locus typer tool for classifying microbial genomes. It provides a fully automated opportunity to customize the classification of genome-wide nucleotide variant data most relevant to biological research. AVAILABILITY: Source code, demo data, and detailed documentation are freely available at http://sourceforge.net/projects/locustyper CONTACT: lbrinkac@jcvi.org or gsutton@jcvi.orgSupplementary information: Supplementary data are available at Bioinformatics online...
January 27, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28105619/-establishment-of-risk-evaluation-model-of-peritoneal-metastasis-in-gastric-cancer-and-its-predictive-value
#9
Junjie Zhao, Rongjian Zhou, Qi Zhang, Ping Shu, Haojie Li, Xuefei Wang, Zhenbin Shen, Fenglin Liu, Weidong Chen, Jing Qin, Yihong Sun
OBJECTIVE: To establish an evaluation model of peritoneal metastasis in gastric cancer, and to assess its clinical significance. METHODS: Clinical and pathologic data of the consecutive cases of gastric cancer admitted between April 2015 and December 2015 in Department of General Surgery, Zhongshan Hospital of Fudan University were analyzed retrospectively. A total of 710 patients were enrolled in the study after 18 patients with other distant metastasis were excluded...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28076847/programmed-cell-death-ligand-1-expression-predicts-survival-in-patients-with-gastric-carcinoma-with-microsatellite-instability
#10
Junhun Cho, Jeeyun Lee, Heejin Bang, Seung Tae Kim, Se Hoon Park, Ji Yeong An, Min Gew Choi, Joon Ho Lee, Tae Sung Sohn, Jae Moon Bae, Won Ki Kang, Sung Kim, Kyoung-Mee Kim
Programmed death-ligand 1 (PD-L1) is expressed in a subgroup of gastric cancers that may benefit from immunotherapy. Microsatellite instability-high (MSI-H) is a potential predictive factor for response to immunotherapy targeting the PD-1 or its ligand PD-L1. The relationship between PD-L1 expression and MSI-H status remains poorly understood. In this study, we investigated PD-L1 expression in patients with MSI-H gastric cancer. We analyzed PD-L1 expression in 78 MSI-H gastric cancer tissue samples using immunohistochemistry...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28067620/characterisation-of-the-opposing-effects-of-g6pd-deficiency-on-cerebral-malaria-and-severe-malarial-anaemia
#11
Geraldine M Clarke, Kirk Rockett, Katja Kivinen, Christina Hubbart, Anna E Jeffreys, Kate Rowlands, Muminatou Jallow, David J Conway, Kalifa A Bojang, Margaret Pinder, Stanley Usen, Fatoumatta Sisay-Joof, Giorgio Sirugo, Ousmane Toure, Mahamadou A Thera, Salimata Konate, Sibiry Sissoko, Amadou Niangaly, Belco Poudiougou, Valentina D Mangano, Edith C Bougouma, Sodiomon B Sirima, David Modiano, Lucas N Amenga-Etego, Anita Ghansah, Kwadwo A Koram, Michael D Wilson, Anthony Enimil, Jennifer Evans, Olukemi K Amodu, Subulade Olaniyan, Tobias Apinjoh, Regina Mugri, Andre Ndi, Carolyne M Ndila, Sophie Uyoga, Alexander Macharia, Norbert Peshu, Thomas N Williams, Alphaxard Manjurano, Nuno Sepúlveda, Taane G Clark, Eleanor Riley, Chris Drakeley, Hugh Reyburn, Vysaul Nyirongo, David Kachala, Malcolm Molyneux, Sarah J Dunstan, Nguyen Hoan Phu, Nguyen Ngoc Quyen, Cao Quang Thai, Tran Tinh Hien, Laurens Manning, Moses Laman, Peter Siba, Harin Karunajeewa, Steve Allen, Angela Allen, Timothy Me Davis, Pascal Michon, Ivo Mueller, Síle F Molloy, Susana Campino, Angeliki Kerasidou, Victoria J Cornelius, Lee Hart, Shivang S Shah, Gavin Band, Chris Ca Spencer, Tsiri Agbenyega, Eric Achidi, Ogobara K Doumbo, Jeremy Farrar, Kevin Marsh, Terrie Taylor, Dominic P Kwiatkowski
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. Here we report an analysis of multiple allelic forms of G6PD deficiency in a large multi-centre case-control study of severe malaria, using the WHO classification of G6PD mutations to estimate each individual's level of enzyme activity from their genotype...
January 9, 2017: ELife
https://www.readbyqxmd.com/read/28040433/bioinformatics-insight-into-glycosyltransferase-gene-expression-in-gastric-cancer-pofut1-is-a-potential-biomarker
#12
Shuang Dong, Zhe Wang, Binbin Huang, Junjie Zhang, Yanli Ge, Qilin Fan, Zhirong Wang
Aberrant glycosylation plays an important role in the progression of gastric cancer. Although many enzymes are involved in glycoconjugate synthesis, little information is known about glycosyltransferase (GT)'s alteration in gastric cancer. To give an insight into the differential expression of GTs as obtained from the TCGA database, bioinformatics analysis of 415 gastric cancer samples and 35 normal samples was performed. Using a 0.6-fold change threshold to compare GT expression in normal and cancer tissues, it was noted that 36 GTs were upregulated including POFUT1 and 30 GTs were downregulated in cancer tissues (P < 0...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28030564/poorly-differentiated-medullary-phenotype-predicts-poor-survival-in-early-lymph-node-negative-gastro-esophageal-adenocarcinomas
#13
Christoph Treese, Pedro Sanchez, Patricia Grabowski, Erika Berg, Hendrik Bläker, Martin Kruschewski, Oliver Haase, Michael Hummel, Severin Daum
BACKGROUND: 5-year survival rate in patients with early adenocarcinoma of the gastro-esophageal junction or stomach (AGE/S) in Caucasian patients is reported to be 60-80%. We aimed to identify prognostic markers for patients with UICC-I without lymph-node involvement (N0). METHODS: Clinical data and tissue specimen from patients with AGE/S stage UICC-I-N0, treated by surgery only, were collected retrospectively. Tumor size, lymphatic vessel or vein invasion, grading, classification systems (WHO, Lauren, Ming), expression of BAX, BCL-2, CDX2, Cyclin E, E-cadherin, Ki-67, TP53, TP21, SHH, Survivin, HIF1A, TROP2 and mismatch repair deficiency were analyzed using tissue microarrays and correlated with overall and tumor related survival...
2016: PloS One
https://www.readbyqxmd.com/read/28029498/determination-of-voc-marker-combinations-for-the-classification-of-individuals-by-gender-and-race-ethnicity
#14
Lauren J Colón-Crespo, Danay Herrera-Hernández, Howard Holness, Kenneth G Furton
Human scent has been demonstrated to allow for the differentiation of individuals. The extent of this differentiation may allow scent to be used as a characteristic, capable of revealing information on an individual's traits. The ability to use scent as a biometric human feature has enabled the use of scent as forensic evidence. However, its reliability, value, and admissibility in courts of law have sometimes been challenged as a result of limited scientific validation. Full acceptance of human scent evidence has been hindered by the limited availability of peer reviewed information that provides greater understanding of how human scent originates and how it may be used...
October 12, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28013168/integrated-analysis-identifies-molecular-signatures-and-specific-prognostic-factors-for-different-gastric-cancer-subtypes
#15
Li Min, Yu Zhao, Shengtao Zhu, Xintao Qiu, Rui Cheng, Jie Xing, Linlin Shao, Shuilong Guo, Shutian Zhang
BACKGROUND: Gastric cancer (GC) is the fifth leading cause of cancer-related deaths worldwide. As an effective and easily performed method, microscopy-based Lauren classification has been widely accepted by gastrointestinal surgeons and pathologists for GC subtyping, but molecular characteristics of different Lauren subtypes were poorly revealed. METHODS: GSE62254 was used as a derivation cohort, and GSE15459 was used as a validation cohort. The difference between diffuse and intestinal GC on the gene expression level was measured...
December 22, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27999983/can-lymphovascular-invasion-be-predicted-by-preoperative-multiphasic-dynamic-ct-in-patients-with-advanced-gastric-cancer
#16
Zelan Ma, Changhong Liang, Yanqi Huang, Lan He, Cuishan Liang, Xin Chen, Xiaomei Huang, Yabing Xiong, Zaiyi Liu
OBJECTIVES: To determine whether multiphasic dynamic CT can preoperatively predict lymphovascular invasion (LVI) in advanced gastric cancer (AGC). METHODS: 278 patients with AGC who underwent preoperative multiphasic dynamic CT were retrospectively recruited. Tumour CT attenuation difference between non-contrast and arterial (ΔAP), portal (ΔPP) and delayed phase (ΔDP), tumour-spleen attenuation difference in the portal phase (ΔT-S), tumour contrast enhancement ratios (CERs), tumour-to-spleen ratio (TSR) and tumour volumes were obtained...
December 20, 2016: European Radiology
https://www.readbyqxmd.com/read/27994652/to-excavate-biomarkers-predictive-of-the-response-for-capecitabine-plus-rad001-through-nanostring-based-multigene-assay-in-advanced-gastric-cancer-patients
#17
Hansang Lee, Jeeyun Lee, Insuk Sohn, Se Hoon Park, Joon Oh Park, Young Suk Park, Kyoung-Mee Kim, Won Ki Kang, Seung Tae Kim
Comprehensive characterization of individual patients' tumour is important to realize personalized medicine. Here, we investigate to identify subsets that benefit from capecitabine plus RAD001 in advanced gastric cancer (GC) patients by comprehensive high-throughput genomic analysis (nCounter assay). Archival tumour tissue blocks, if possible, were collected at phase II trial of capecitabine plus RAD001 in 47 refractory GC patients (at clinicaltrials.gov NCT#01099527). A total of 42 formalin-fixed, paraffin-embedded (FFPE) tumour samples were available for nanostring based-multigene Assay...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27990300/agreement-between-gonioscopic-examination-and-swept-source-fourier-domain-anterior-segment-optical-coherence-tomography-imaging
#18
Mohammed Rigi, Nicholas P Bell, David A Lee, Laura A Baker, Alice Z Chuang, Donna Nguyen, Vandana R Minnal, Robert M Feldman, Lauren S Blieden
Purpose. To evaluate interobserver, intervisit, and interinstrument agreements for gonioscopy and Fourier domain anterior segment optical coherence tomography (FD ASOCT) for classifying open and narrow angle eyes. Methods. Eighty-six eyes with open or narrow anterior chamber angles were included. The superior angle was classified open or narrow by 2 of 5 glaucoma specialists using gonioscopy and imaged by FD ASOCT in the dark. The superior angle of each FD ASOCT image was graded as open or narrow by 2 masked readers...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27934877/overexpression-and-gene-amplification-of-pd-l1-in-cancer-cells-and-pd-l1-immune-cells-in-epstein-barr-virus-associated-gastric-cancer-the-prognostic-implications
#19
Ruri Saito, Hiroyuki Abe, Akiko Kunita, Hiroharu Yamashita, Yasuyuki Seto, Masashi Fukayama
Cancer cells use PD-L1 to evade antitumor immunity through interaction with programmed cell death protein 1 (PD-1) on T cells. Recent whole-genome sequence studies revealed frequent gene amplification of PD-L1 in Epstein-Barr virus-associated gastric cancer (EBVaGC). To investigate the significance of PD-L1 in cancer cells and their microenvironment in EBVaGC, we studied PD-L1 expression by analysis of the public database and immunohistochemistry with fluorescent in situ hybridization (FISH) of the PD-L1 gene...
December 9, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27901487/hoxb7-overexpression-promotes-cell-proliferation-and-correlates-with-poor-prognosis-in-gastric-cancer-patients-by-inducing-expression-of-both-akt-and-marks
#20
Xujun He, Zhengchuang Liu, Yingjie Xia, Ji Xu, Guocai Lv, Lu Wang, Tonghui Ma, Liping Jiang, Yiping Mou, Xiaoting Jiang, Jie Ma, Zhongkuo Zhao, Haibin Ni, Wenjuan Xu, Guoqing Ru, Dongsheng Huang, Houquan Tao
Increased expression of HOXB7 has been reported to correlate with the progression in many cancers. However, the specific mechanism by which it promotes the evolution of gastric cancer (GC) is poorly understood.In this study, we sought to investigate the role of HOXB7 in GC by assessing HOXB7 expression in patient tissue and its correlation to clinical characteristics. We found that GC tissues showed increased expression of HOXB7 and that the HOXB7 expression was significantly associated with Lauren classification, invasion depth, lymphatic metastasis and poor prognosis, and could serve as an independent prognostic factor...
January 3, 2017: Oncotarget
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