keyword
https://read.qxmd.com/read/38536655/18f-fdg-pet-ct-metabolism-multi-parameter-prediction-of-chemotherapy-efficacy-in-locally-progressive-gastric-cancer
#1
JOURNAL ARTICLE
Luqiang Jin, Linghe Zhang, Liping Fu, Fahuan Song, Aiping Cheng
PURPOSE: This study aimed to use an 18 F-FDG PET/CT multiparametric quantitative analysis to determine the efficacy of neoadjuvant chemotherapy in patients with locally progressive gastric cancer. MATERIALS AND METHODS: We conducted a retrospective analysis of 34 patients with pathologically identified gastric cancer who received neoadjuvant chemotherapy and surgery. Chemotherapy regimens were followed and 18 F-FDG PET/CT was conducted. We ascertained multiparamaters of the target lesions pre- and post-treatment and determined the ideal cutoff values for the percentage change in biomarkers...
March 27, 2024: Annals of Nuclear Medicine
https://read.qxmd.com/read/38506267/comparison-of-clinical-outcomes-of-several-risk-stratification-tools-in-newly-diagnosed-aml-patients-a-real-world-evidence-in-our-current-therapeutic-era
#2
JOURNAL ARTICLE
Alexandre Iat, Michael Loschi, Sami Benachour, Anne Calleja, Edmond Chiche, Isabelle Sudaka, Danièle Aquaronne, Corinne Ferrero, Laurène Fenwarth, Alice Marceau, Elise Fournier, Berengere Dadone-Montaudie, Thomas Cluzeau
BACKGROUND OF THE STUDY: AML classification tools have been developed to stratify the risk at AML diagnosis. There is a need to evaluate these tools in the current therapeutic era. COHORT CHARACTERISTICS: In this retrospective study, we compared five classifiers: ELN 2017, ELN 2022, ALFA classifier, Papaemmanuil et al. classifier, and Lindsley et al. classifier, in a real-life cohort of 281 patients newly diagnosed for AML in Nice University Hospital. In our cohort median age was 68 years old, sex ratio was M/F 56%/44%, performance status was lower than 2 in 73...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38502241/associations-between-daily-step-count-classifications-and-continuous-glucose-monitoring-metrics-in-adults-with-type-1-diabetes-analysis-of-the-type-1-diabetes-exercise-initiative-t1dexi-cohort
#3
JOURNAL ARTICLE
Lauren V Turner, Martin Chase Marak, Robin L Gal, Peter Calhoun, Zoey Li, Peter G Jacobs, Mark A Clements, Corby K Martin, Francis J Doyle, Susana R Patton, Jessica R Castle, Melanie B Gillingham, Roy W Beck, Michael R Rickels, Michael C Riddell
AIMS/HYPOTHESIS: Adults with type 1 diabetes should perform daily physical activity to help maintain health and fitness, but the influence of daily step counts on continuous glucose monitoring (CGM) metrics are unclear. This analysis used the Type 1 Diabetes Exercise Initiative (T1DEXI) dataset to investigate the effect of daily step count on CGM-based metrics. METHODS: In a 4 week free-living observational study of adults with type 1 diabetes, with available CGM and step count data, we categorised participants into three groups-below (<7000), meeting (7000-10,000) or exceeding (>10,000) the daily step count goal-to determine if step count category influenced CGM metrics, including per cent time in range (TIR: 3...
March 19, 2024: Diabetologia
https://read.qxmd.com/read/38500887/case-report-a-case-of-advanced-gastric-cancer-with-multiple-skin-metastases-with-significant-relief-from-immunotherapy
#4
Wen Hao, Ruimin Chang, Jingxin Liu, Yibing Wang, Meijin Ren, Kai Xin, Baorui Liu, Jiaqi Xie, Yang Yang
Gastric cancer is the fifth leading cause of cancer-related mortality worldwide, with a low 5-year survival rate in advanced stages. Cutaneous metastasis is rare in gastric cancer, with only 0.8-1% incidence. We reported a rare case of female gastric cancer. The patient had undergone subtotal gastrectomy and chemotherapy 13 years ago, followed by a subsequent surgery of residual stomach, partial jejunum, and partial colon resection 11 years later. The pathological examination revealed poorly differentiated stomach adenocarcinoma, Lauren classification: diffuse type...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38482420/comparable-prognosis-of-early-gastric-cancer-between-intestinal-type-and-diffuse-type-in-patients-of-age-75-and-older-a-seer-based-cohort-study
#5
JOURNAL ARTICLE
Ping Yin, Rencheng Cai, Xiaohua Zhou, Xuemin Yao, Qiufen Yang, Yuehong Jin, Xuehua Jiao, Chengjie Lu, Zhenguo Qiao
BACKGROUND: The prognostic significance of Lauren's classification in elderly early gastric cancer (EGC) patients remains largely unknown. We aim to investigate the characteristics and clinical implications of Lauren's classification in elderly EGC patients. METHODS: Patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database based on the inclusion and exclusion criteria. Univariate and multivariate Cox regression, propensity score matching, inverse-probability-weighted analysis, and propensity-score adjustment were utilized to evaluate the association between Lauren's classification and cancer-specific survival (CSS) in elderly EGC patients...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38476439/management-of-suicidal-risk-in-the-emergency-department-a-clinical-pathway-using-the-computerized-adaptive-screen-for-suicidal-youth
#6
JOURNAL ARTICLE
Jacqueline Grupp-Phelan, Adam Horwitz, David Brent, Lauren Chernick, Rohit Shenoi, Charlie Casper, Michael Webb, Cheryl King
OBJECTIVE: Given the critical need for efficient and tailored suicide screening for youth presenting in the emergency department (ED), this study establishes validated screening score thresholds for the Computerized Adaptive Screen for Suicidal Youth (CASSY) and presents an example of a suicide risk classification pathway. METHODS: Participants were primarily from the Study One derivation cohort of the Emergency Department Screen for Teens at Risk for Suicide (ED-STARS) enrolled in collaboration with Pediatric Emergency Care Applied Research Networks (PECARN)...
April 2024: Journal of the American College of Emergency Physicians open
https://read.qxmd.com/read/38472645/rethinking-the-consultation-paradigm-validity-evidence-for-a-new-framework-a-multimethods-study
#7
JOURNAL ARTICLE
Rushad Patell, Joséphine A Cool, Elise Merchant, Laura E Dodge, Daniel N Ricotta, Brian Persaud, Larissa K Gomez, Lauren Yang, Alison Trainor, Brian Carney, Jeffrey William, Stewart Lecker, Miranda Theodore, Camille Petri, Douglas Horst, Daniel Stein, Natalia Forbath, Abdul Azim, Andrew J Hale, Jason A Freed
BACKGROUND: In-hospital consultation is essential for patient care. We previously proposed a framework of seven specific consultation types to classify consult requests to improve communication, workflow, and provider satisfaction. METHODS: This multimethods study's aim was to evaluate the applicability of the consult classification framework to real internal medicine (IM) consults. We sought validity evidence using Kane's validity model with focus groups and classifying consult requests from five IM specialties...
March 12, 2024: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://read.qxmd.com/read/38466820/early-versus-delayed-definitive-fixation-relative-to-fasciotomy-closure-in-high-energy-tibial-plateau-fractures-with-compartment-syndrome
#8
JOURNAL ARTICLE
Ilexa Flagstad, Patrick Albright, Tony Pedri, Rebekah M Kleinsmith, Andrew Schmidt, Maxwell Alley, Jerald R Westberg, Andres Fidel Moreno, Greer Henry, Lauren M Tatman, William T Obremskey, Paul Tornetta, Brian P Cunningham
OBJECTIVES: To evaluate the timing of definitive fixation of tibial plateau fractures relative to fasciotomy closure with regards to alignment and articular reduction. METHODS: Design: Retrospective Case Series. SETTING: Four Level I trauma centers. PATIENT SELECTION CRITERIA: Patients with tibial plateau fractures with ipsilateral compartment syndrome treated with fasciotomy between 2006-2018 met inclusion criteria...
March 8, 2024: Journal of Orthopaedic Trauma
https://read.qxmd.com/read/38439568/pathologic-classification-of-a-late-onset-peripheral-neuropathy-in-a-spontaneous-labrador-retriever-dog-model
#9
JOURNAL ARTICLE
Ryan S Anderson, Alexander K Chu, Helena Rylander, Emily E Binversie, Ian D Duncan, Lauren Baker, Shahriar Salamat, Margaret M Patterson, Jordan Gruel, Nyah L Kohler, Hannah K Kearney, Shelby M Ale, Mehdi M Momen, Peter Muir, John P Svaren, Rebecca Johnson, Susannah J Sample
Late-onset peripheral neuropathy (LPN) is a heritable canine neuropathy commonly found in Labrador retrievers and is characterized by laryngeal paralysis and pelvic limb paresis. Our objective was to establish canine LPN as a model for human hereditary peripheral neuropathy by classifying it as either an axonopathy or myelinopathy and evaluating length-dependent degeneration. We conducted a motor nerve conduction study of the sciatic and ulnar nerves, electromyography (EMG) of appendicular and epaxial musculature, and histologic analysis of sciatic and recurrent laryngeal nerves in LPN-affected and control dogs...
March 2024: Journal of Comparative Neurology
https://read.qxmd.com/read/38437945/timing-is-everything-towards-classification-criteria-for-early-stage-symptomatic-knee-osteoarthritis
#10
JOURNAL ARTICLE
Armaghan Mahmoudian, Lauren K King, Jean W Liew, Qiuke Wang, C Thomas Appleton, Martin Englund, Ida K Haugen, L Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, Tuhina Neogi, Gillian A Hawker
No abstract text is available yet for this article.
March 2, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38433351/comparison-of-migraine-with-left-versus-right-sided-headache-a-cross-sectional-study
#11
JOURNAL ARTICLE
Adam S Sprouse Blum, Lauren A DaSilva, Michael D Greenberg, Alexander J Nissenbaum, Robert E Shapiro, Benjamin Littenberg
OBJECTIVE: The goal of this study was to clarify whether clinical differences exist between patients with migraine who experience headache that is typically left-sided ("left-migraine") versus right-sided ("right-migraine") during attacks. BACKGROUND: Migraine has been associated with unilateral headache for millennia and remains a supportive trait for the clinical diagnosis of migraine of the International Classification of Headache Disorders. It is currently unknown why headache in migraine is commonly unilateral, and whether headache-sidedness is associated with other clinical features...
March 3, 2024: Headache
https://read.qxmd.com/read/38432196/neonatal-extracorporeal-membrane-oxygenation-associations-between-continuous-renal-replacement-therapy-thrombocytopenia-and-outcomes
#12
JOURNAL ARTICLE
Lauren R Walker, Laura E Hollinger, W Michael Southgate, David T Selewski, Jeffrey E Korte, Mathew Gregoski, Heidi J Steflik
INTRODUCTION: The incidence of thrombocytopenia in neonates receiving extracorporeal membrane oxygenation (ECMO) with and without concurrent continuous renal replacement therapy (CRRT) and associated complications have not been well described. The primary aims of the current study were to (1) characterize thrombocytopenia in neonates receiving ECMO (including treated concurrently with CRRT) and (2) evaluate risk factors (including CRRT utilization) associated with severe thrombocytopenia...
March 1, 2024: Blood Purification
https://read.qxmd.com/read/38430053/clinical-characteristics-of-treatment-seeking-youth-with-misophonia
#13
JOURNAL ARTICLE
Adam B Lewin, Lauren Milgram, Sandra L Cepeda, Sarah Dickinson, Morgan Bolen, Kelly Kudryk, Cassidy Bolton, Ashley R Karlovich, Hannah L Grassie, Aileen Kangavary, Sherelle L Harmon, Andrew Guzick, Jill Ehrenreich-May
OBJECTIVE: Misophonia is a psychiatric condition characterized by strong emotional and/or behavioral responses to auditory stimuli, leading to distress and functional impairment. Despite previous attempts to define and categorize this condition, misophonia is not currently included in the Diagnostic and Statistical Manual of Mental Disorders or International Classification of Diseases. The lack of formal diagnostic consensus presents challenges for research aimed at assessing and treating this clinical presentation...
March 2, 2024: Journal of Clinical Psychology
https://read.qxmd.com/read/38423763/single-cell-analysis-of-rohon-beard-neurons-implicates-fgf-signaling-in-axon-maintenance-and-cell-survival
#14
JOURNAL ARTICLE
Adam M Tuttle, Lauren N Miller, Lindsey J Royer, Hua Wen, Jimmy J Kelly, Nicholas L Calistri, Laura M Heiser, Alex V Nechiporuk
Peripheral sensory neurons are a critical part of the nervous system that transmit a multitude of sensory stimuli to the central nervous system. During larval and juvenile stages in zebrafish, this function is mediated by Rohon-Beard somatosensory neurons (RBs). RBs are optically accessible and amenable to experimental manipulation, making them a powerful system for mechanistic investigation of sensory neurons. Previous studies provided evidence that RBs fall into multiple subclasses; however, the number and molecular make up of these potential RB subtypes have not been well defined...
February 29, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38414452/surgical-and-oncological-outcome-after-extended-lymph-node-dissection-for-carcinoma-of-the-stomach-and-the-esophagogastric-junction-a-retrospective-analysis-from-an-experienced-single-center
#15
JOURNAL ARTICLE
Dimitrios Raptis, Matthias Maak, Christian Krautz, Susanne Merkel, Maximilian Brunner, Abbas Agaimy, Arndt Hartmann, Sabine Semrau, Oliver Ott, Fietkau Rainer, Jürgen Siebler, Robert Grützmann, Werner Hohenberger, Claus-Wilhelm Schildberg
INTRODUCTION: Gastric cancer remains the fourth leading cause of cancer-related death in Europe, while the proportion of adenocarcinomas of the esophagogastric junction has risen by more than one third over recent years. In 2018, 14,700 new cases of gastric cancer were estimated in Germany, while the 5-year relative survival rate is reported to be 33% for women and 30% for men; in the USA almost the same rate was reported, with 31% 5-year survival. MATERIAL AND METHODS: Between 2001 and 2014, 590 patients with a diagnosis of gastric cancer underwent surgery in our institution, including 120 Siewert type II/III carcinomas of the esophagogastric junction...
2024: Archives of Medical Science: AMS
https://read.qxmd.com/read/38392195/clinical-and-genetic-characteristics-of-early-and-advanced-gastric-cancer
#16
JOURNAL ARTICLE
Gi Won Ha, Hong Pil Hwang, Yong Gon Cho, Joonhong Park
Gastric cancer (GC) persists as the fourth most prevalent cause of global cancer-related mortality, presenting a challenge due to the scarcity of available therapeutic strategies. Precision medicine is crucial not only in the treatment but also in the management of GC. We performed gene panel sequencing with Oncomine focus assay comprising 52 cancer-associated genes and MSI analysis in 100 case-matched gastric cancer cases. A comprehensive analysis of clinical and genetic characteristics was conducted on these genetic results and clinicopathological findings...
February 1, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38386322/impact-of-the-communities-that-heal-intervention-on-buprenorphine-waivered-practitioners-and-buprenorphine-prescribing-a-prespecified-secondary-analysis-of-the-hcs-randomized-clinical-trial
#17
JOURNAL ARTICLE
Thomas J Stopka, Denise C Babineau, Erin B Gibson, Charles E Knott, Debbie M Cheng, Jennifer Villani, Jonathan M Wai, Derek Blevins, James L David, Dawn A Goddard-Eckrich, Michelle R Lofwall, Richard Massatti, Jolene DeFiore-Hyrmer, Michael S Lyons, Laura C Fanucchi, Daniel R Harris, Jeffery Talbert, Lindsey Hammerslag, Devin Oller, Raymond R Balise, Daniel J Feaster, William Soares, Gary A Zarkin, LaShawn Glasgow, Emmanuel Oga, John McCarthy, Lauren D'Costa, Rouba Chahine, Steve Gomori, Netrali Dalvi, Shikhar Shrestha, Chad Garner, Aimee Shadwick, Pamela Salsberry, Michael W Konstan, Bridget Freisthler, John Winhusen, Nabila El-Bassel, Jeffrey H Samet, Sharon L Walsh
IMPORTANCE: Buprenorphine significantly reduces opioid-related overdose mortality. From 2002 to 2022, the Drug Addiction Treatment Act of 2000 (DATA 2000) required qualified practitioners to receive a waiver from the Drug Enforcement Agency to prescribe buprenorphine for treatment of opioid use disorder. During this period, waiver uptake among practitioners was modest; subsequent changes need to be examined. OBJECTIVE: To determine whether the Communities That HEAL (CTH) intervention increased the rate of practitioners with DATA 2000 waivers and buprenorphine prescribing...
February 5, 2024: JAMA Network Open
https://read.qxmd.com/read/38372405/prevalence-of-cyp2d6-structural-variation-in-large-retrospective-study
#18
JOURNAL ARTICLE
Samantha Frear, Ashley Sherman, Don Rule, Lauren Ann Marcath
CYP2D6 is a highly polymorphic gene with clinically important structural variations. Commonly, only exon 9 is assayed on clinical pharmacogenomics panels, as it allows for accurate functional characterization even in the presence of a CYP2D6::CYP2D7 conversion. However, this method does not capture CYP2D7::CYP2D6 (CYP2D6*13) conversions, possibly leading to inaccurate phenotype assignment. The study's purpose was to determine the frequency of structural variations in CYP2D6 utilizing multiple copy number variation (CNV) assay locations to quantify the potential impact on clinical phenotype classification...
February 19, 2024: Pharmacogenetics and Genomics
https://read.qxmd.com/read/38358743/traumatic-brain-injury-and-subsequent-risk-of-brain-cancer-in-us-veterans-of-the-iraq-and-afghanistan-wars
#19
JOURNAL ARTICLE
Ian J Stewart, Jeffrey T Howard, Eduard Poltavskiy, Michael Dore, Megan E Amuan, Krista Ocier, Lauren E Walker, Karl C Alcover, Mary Jo Pugh
IMPORTANCE: While brain cancer is rare, it has a very poor prognosis and few established risk factors. To date, epidemiologic work examining the potential association of traumatic brain injury (TBI) with the subsequent risk of brain cancer is conflicting. Further data may be useful. OBJECTIVE: To examine whether a history of TBI exposure is associated with the subsequent development of brain cancer. DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort study was conducted from October 1, 2004, to September 20, 2019, and data analysis was performed between January 1 and June 26, 2023...
February 5, 2024: JAMA Network Open
https://read.qxmd.com/read/38355019/disease-behaviour-classification-a-pragmatic-model-for-predicting-outcomes-in-interstitial-lung-disease
#20
JOURNAL ARTICLE
Megan Harrison, Helen E Jo, Lauren K Troy, Benjamin Nguyen, Susanne E Webster, Monika Geis, Simon Lai, Ellie Mulyadi, Wendy A Cooper, Annabelle Mahar, Alan Teoh, Adelle Jee, Tamera J Corte
BACKGROUND AND OBJECTIVE: The interstitial lung diseases (ILD) are a heterogenous group of disorders with similar clinical presentation, but widely varying prognoses. The use of a pragmatic disease behaviour classification (DBC), first proposed in international guidelines in 2013, categorises diseases into five behavioural classes based on their predicted clinical course. This study aimed to determine the prognostic utility of the DBC in an ILD cohort. METHODS: Consecutive patients presented at the weekly multidisciplinary meeting (MDM) of a specialist ILD centre were included...
February 12, 2024: Respiratory Medicine
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