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Lauren classification

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https://www.readbyqxmd.com/read/28926963/broad-and-inconsistent-muscle-food-classification-is-problematic-for-dietary-guidance-in-the-u-s
#1
REVIEW
Cody L Gifford, Lauren E O'Connor, Wayne W Campbell, Dale R Woerner, Keith E Belk
Dietary recommendations regarding consumption of muscle foods, such as red meat, processed meat, poultry or fish, largely rely on current dietary intake assessment methods. This narrative review summarizes how U.S. intake values for various types of muscle foods are grouped and estimated via methods that include: (1) food frequency questionnaires; (2) food disappearance data from the U.S. Department of Agriculture Economic Research Service; and (3) dietary recall information from the National Health and Nutrition Examination Survey data...
September 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28922362/early-relapses-after-adjuvant-chemotherapy-suggests-primary-chemoresistance-in-diffuse-gastric-cancer
#2
Sharon Pattison, Catherine Mitchell, Stephen Lade, Trevor Leong, Rita A Busuttil, Alex Boussioutas
BACKGROUND: Survival from gastric cancer remains poor, particularly in Western populations. Previous pre-clinical and subgroup analyses of clinical trials have suggested differing benefits from fluoropyrimidine-based chemotherapeutics for diffuse and intestinal gastric cancer. This analysis examines patterns of relapse with and without adjuvant chemotherapy after curative resection for gastric cancer in these subtypes to explore the Lauren classification as a predictive marker of benefit for fluoropyrimidine-based adjuvant chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28903154/incidence-and-trends-of-sepsis-in-us-hospitals-using-clinical-vs-claims-data-2009-2014
#3
Chanu Rhee, Raymund Dantes, Lauren Epstein, David J Murphy, Christopher W Seymour, Theodore J Iwashyna, Sameer S Kadri, Derek C Angus, Robert L Danner, Anthony E Fiore, John A Jernigan, Greg S Martin, Edward Septimus, David K Warren, Anita Karcz, Christina Chan, John T Menchaca, Rui Wang, Susan Gruber, Michael Klompas
Importance: Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time. Objective: To estimate the US national incidence of sepsis and trends using detailed clinical data from the electronic health record (EHR) systems of diverse hospitals. Design, Setting, and Population: Retrospective cohort study of adult patients admitted to 409 academic, community, and federal hospitals from 2009-2014...
September 13, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28900323/detection-and-significance-of-human-epidermal-growth-factor-receptor-2-expression-in-gastric-adenocarcinoma
#4
Sutapa Halder, Debjani Mallick, Priyanka Mondal, Debajyoti Singha Roy, Aniket Halder, Sudipta Chakrabarti
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is involved in the pathogenesis of several types of cancer, including gastric cancer. Overexpression of HER2 is noted in 10%-22.8% of gastric adenocarcinoma and its identification is of immense importance for management by targeted drugs. Detection of HER2 expression in gastric malignancies has not been undertaken previously in the local population. OBJECTIVE: To ascertain HER2 immunohistochemical expression in gastric adenocarcinoma and its relationship with the anatomic location and histomorphology...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28891405/projecting-survival-in-papillary-thyroid-cancer-a-comparison-of-the-7th-and-8th-editions-of-the-ajcc-uicc-staging-systems-in-two-contemporary-national-patient-cohorts
#5
Lauren N Pontius, Taofik O Oyekunle, Samantha Thomas, Michael Stang, Randall P Scheri, Sanziana Roman, Julie Ann Sosa
BACKGROUND: This study aims to compare the 7th and 8th editions of the AJCC/UICC TNM staging system for patients with papillary thyroid cancer (PTC) in two national patient cohorts. METHODS: Adult PTC patients undergoing surgery were selected from SEER (2004-2012) and NCDB (2004-2012). Staging criteria for the 7th and 8th AJCC/UICC editions were applied separately to both cohorts; survival probabilities were estimated using the Kaplan-Meier method. Multivariable Cox proportional hazards models were used to estimate the association of stage with survival in both settings...
September 11, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28857517/cisd2-enhances-the-chemosensitivity-of-gastric-cancer-through-the-enhancement-of-5-fu-induced-apoptosis-and-the-inhibition-of-autophagy-by-akt-mtor-pathway
#6
Yi Sun, Yingming Jiang, Jintuan Huang, Hao Chen, Yi Liao, Zuli Yang
Gastric cancer (GC) is a prevalent upper gastrointestinal tumor characterized by high morbidity and mortality due to imperfect screening systems and the rapid development of resistance to 5-fluorouracil (5-FU). CDGSH iron sulfur domain 2 (CISD2) has been recently regarded as a candidate oncogene in several types of tumors. It is, therefore, necessary to investigate its biological function and clinical significance in gastric cancer. In this study, the down-regulated expression level of CISD2 in GC compared with adjacent normal tissues was evaluated by quantitative RT-PCR and Western blotting...
August 31, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28844436/psychosis-subgroups-differ-in-intrinsic-neural-activity-but-not-task-specific-processing
#7
Matthew E Hudgens-Haney, Lauren E Ethridge, Jennifer E McDowell, Sarah K Keedy, Godfrey D Pearlson, Carol A Tamminga, Matcheri S Keshavan, John A Sweeney, Brett A Clementz
Individuals with psychosis often show high levels of intrinsic, or nonspecific, neural activity, but attenuated stimulus-specific activity. Clementz et al. (2016) proposed that one subgroup of psychosis cases has accentuated intrinsic activity (Biotype-2's) and a different subgroup (Biotype-1's) has diminished intrinsic activity, with both groups exhibiting varying degrees of cognitive deficits. This model was studied by assessing neural activity in psychosis probands (N=105) during baseline and a 5second period in preparation for a pro-/anti-saccade task...
August 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28800570/clinical-evaluation-of-the-spinal-instability-neoplastic-score-in-patients-treated-with-radiotherapy-for-symptomatic-spinal-bone-metastases
#8
Laurens Bollen, Karlijn Groenen, Willem Pondaag, Carla S P van Rijswijk, Marta Fiocco, Yvette M Van der Linden, Sander P D Dijkstra
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To determine the predictive value of the Spinal Instability Neoplastic Score (SINS) in a cohort of patients treated with radiotherapy for spinal bone metastases. SUMMARY OF BACKGROUND DATA: Assessment of spinal stability in metastatic disease is challenging and is mostly done by relying on clinical experience, in the absence of validated guidelines or an established predetermined set of risk factors...
August 15, 2017: Spine
https://www.readbyqxmd.com/read/28765618/lauren-subtypes-of-advanced-gastric-cancer-influence-survival-and-response-to-chemotherapy-real-world-data-from-the-agamenon-national-cancer-registry
#9
MULTICENTER STUDY
Paula Jiménez Fonseca, Alberto Carmona-Bayonas, Raquel Hernández, Ana Custodio, Juana Maria Cano, Alejandra Lacalle, Isabel Echavarria, Ismael Macias, Monserrat Mangas, Laura Visa, Elvira Buxo, Felipe Álvarez Manceñido, Antonio Viudez, Carles Pericay, Aitor Azkarate, Avinash Ramchandani, Carlos López, Eva Martinez de Castro, Ana Fernández Montes, Federico Longo, Rodrigo Sánchez Bayona, Maria Luisa Limón, Asun Diaz-Serrano, Alfonso Martin Carnicero, David Arias, Paula Cerdà, Fernando Rivera, Jose Maria Vieitez, Manuel Sánchez Cánovas, M Garrido, J Gallego
BACKGROUND: The choice of chemotherapy in HER2-negative gastric cancer is based on centre's preferences and adverse effects profile. No schedule is currently accepted as standard, nor are there any factors to predict response, other than HER2 status. We seek to evaluate whether Lauren type influences the efficacy of various chemotherapies and on patient overall survival (OS). METHODS: We have conducted a multicenter study in 31 hospitals. The eligibility criteria include diagnosis of stomach or gastroesophageal junction adenocarcinoma, HER2 negativity, and chemotherapy containing 2-3 drugs...
September 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28751629/ceacam6-is-a-prognostic-biomarker-and-potential-therapeutic-target-for-gastric-carcinoma
#10
Guo-Qing Ru, Yong Han, Wei Wang, Yuan Chen, Hui-Ju Wang, Wen-Juan Xu, Jie Ma, Meihua Ye, Xi Chen, Xiang-Lei He, Balázs Győrffy, Zhong-Sheng Zhao, Dongsheng Huang
This study aims to investigate the prognostic power of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) in gastric cancer (GC) and its potential role in cancer development and progression. Data mining results show that CEACAM6 is overexpressed in gastric cancer and is correlated with lymph node metastasis. Subsequently, immunohistochemical staining was performed to determine CEACAM6 protein levels in paraffin gastric tumor specimens. Real-time reverse-transcription-polymerase chain reaction (RT-PCR) was conducted to detect CEACAM6 mRNA levels in fresh GC samples...
July 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28738684/drivers-of-excess-costs-of-opioid-abuse-among-a-commercially-insured-population
#11
Lauren M Scarpati, Noam Y Kirson, Miriam L Zichlin, Zitong B Jia, Howard G Birnbaum, Jaren C Howard
OBJECTIVES: To replicate and extend a recently published analysis of the drivers of excess costs of opioid abuse. STUDY DESIGN: Retrospective data analysis using de-identified claims data from the Truven MarketScan Commercial Claims and Encounter database. METHODS: Medical and prescription drug claims from beneficiaries covered by large self-insured US companies were used to select patients with incident diagnoses of opioid abuse between 2012 and 2015...
May 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28736645/effect-of-helicobacter-pylori-infection-on-outcomes-in-resected-gastric-and-gastroesophageal-junction-cancer
#12
Jennifer M Kolb, Umut Ozbek, Noam Harpaz, Randall F Holcombe, Celina Ang
BACKGROUND: Helicobacter pylori (H pylori) infection is a known risk factor for gastric cancer (GC) and has been linked with gastroesophageal junction (GEJ) cancer. Studies examining the relationship between H. pylori infection, GC characteristics and prognosis are limited and have yielded conflicting results. We report on the clinicopathologic characteristics and oncologic outcomes of gastric and GEJ cancer patients with and without a history of H. pylori treated at our institution. METHODS: We retrospectively reviewed the medical records of patients over the age of 18 years who underwent curative resection for GEJ and GC at Mount Sinai Hospital between 2007 and 2012 who had histopathologic documentation of the presence or absence of H pylori infection...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28733654/direct-observation-of-topological-surface-state-arcs-in-photonic-metamaterials
#13
Biao Yang, Qinghua Guo, Ben Tremain, Lauren E Barr, Wenlong Gao, Hongchao Liu, Benjamin Béri, Yuanjiang Xiang, Dianyuan Fan, Alastair P Hibbins, Shuang Zhang
The discovery of topological phases has introduced new perspectives and platforms for various interesting physics originally investigated in quantum contexts and then, on an equal footing, in classic wave systems. As a characteristic feature, nontrivial Fermi arcs, connecting between topologically distinct Fermi surfaces, play vital roles in the classification of Dirac and Weyl semimetals, and have been observed in quantum materials very recently. However, in classical systems, no direct experimental observation of Fermi arcs in momentum space has been reported so far...
July 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28693253/telomere-length-is-correlated-with-mitochondrial-dna-copy-number-in-intestinal-but-not-diffuse-gastric-cancer
#14
Soo-Jung Jung, Ji-Hyoung Cho, Won-Jin Park, Yu-Ran Heo, Jae-Ho Lee
A positive correlation between telomere length and mitochondrial DNA (mtDNA) copy number has previously been observed in healthy individuals, and in patients with psychiatric disorders. In the present study, telomere length and mtDNA copy number were evaluated in gastric cancer (GC) tissue samples. DNA was extracted from 109 GC samples (including 82 intestinal, and 27 diffuse cases), and the telomere length and mtDNA copy number were analyzed using a quantitative-polymerase chain reaction assay. The relative telomere length and mtDNA copy number in tumor tissue, as compared with in normal tissue, (mean ± standard deviation) in all GC samples were 11...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28685258/migraine-and-the-risk-of-post-traumatic-stress-disorder-among-a-cohort-of-pregnant-women
#15
Lauren E Friedman, Christina Aponte, Rigoberto Perez Hernandez, Juan Carlos Velez, Bizu Gelaye, Sixto E Sánchez, Michelle A Williams, B Lee Peterlin
BACKGROUND: Individually both migraine and post-traumatic stress disorder (PTSD) prevalence estimates are higher among women. However, there is limited data on the association of migraine and PTSD in women during pregnancy. METHODS: We examined the association between migraine and PTSD among women attending prenatal clinics in Peru. Migraine was characterized using the International Classification of Headache Disorders (ICHD)-III beta criteria. PTSD was assessed using the PTSD Checklist-Civilian Version (PCL-C)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28683070/physical-activity-domains-and-risk-of-gastric-adenocarcinoma-in-the-mcc-spain-case-control-study
#16
José M Huerta, María Dolores Chirlaque, Antonio J Molina, Pilar Amiano, Vicente Martín, Tania Fernández-Villa, Beatriz Pérez-Gómez, Víctor Moreno, Rosana Burgui, Inés Gómez-Acebo, Manuel Ramos-Lora, Guillermo Fernández-Tardón, Rosana Peiró, Rocío Olmedo-Requena, Marina Pollán, Manolis Kogevinas, Gemma Castaño-Vinyals, Nuria Aragonés
BACKGROUND: Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study. METHODS: 428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas...
2017: PloS One
https://www.readbyqxmd.com/read/28679451/the-significance-of-a-nineteenth-century-definition-in-the-era-of-genomics-linitis-plastica
#17
REVIEW
Annamaria Agnes, Jeannelyn S Estrella, Brian Badgwell
BACKGROUND: Linitis plastica due to gastric adenocarcinoma is a condition with a long history, but still lacks a standardized definition and is commonly confused with Borrmann type IV, Lauren diffuse, and signet-cell type gastric cancer. The absence of a clear definition is a problem when investigating its biological characteristics and role as a possible independent factor for prognosis. Nevertheless, the biological behavior for linitis plastica, which is unique, may be valuable in risk stratification and have implications for treatment...
July 5, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28643092/application-of-ct-texture-analysis-in-predicting-histopathological-characteristics-of-gastric-cancers
#18
Shunli Liu, Song Liu, Changfeng Ji, Huanhuan Zheng, Xia Pan, Yujuan Zhang, Wenxian Guan, Ling Chen, Yue Guan, Weifeng Li, Jian He, Yun Ge, Zhengyang Zhou
OBJECTIVES: To explore the application of computed tomography (CT) texture analysis in predicting histopathological features of gastric cancers. METHODS: Preoperative contrast-enhanced CT images and postoperative histopathological features of 107 patients (82 men, 25 women) with gastric cancers were retrospectively reviewed. CT texture analysis generated: (1) mean attenuation, (2) standard deviation, (3) max frequency, (4) mode, (5) minimum attenuation, (6) maximum attenuation, (7) the fifth, 10th, 25th, 50th, 75th and 90th percentiles, and (8) entropy...
June 22, 2017: European Radiology
https://www.readbyqxmd.com/read/28631563/prognostic-significance-of-glutathione-peroxidase-2-in-gastric-carcinoma
#19
Dongzhe Liu, Liang Sun, Jinxue Tong, Xiuhui Chen, Hui Li, Qifan Zhang
Increasing evidence suggests that the glutathione peroxidase 2 may actually play important roles in tumorigenesis and progression in various human cancers such as colorectal carcinomas and lung adenocarcinomas. However, the role of glutathione peroxidase 2 in gastric carcinoma remains to be determined. In this study, the expression and prognostic significance of glutathione peroxidase 2 in gastric carcinoma were investigated and the well-known prognostic factor Ki-67 labeling index was also assessed as positive control...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28598723/use-of-the-columbia-suicide-severity-rating-scale-c-ssrs-to-classify-suicidal-behaviors
#20
Alejandro Interian, Megan Chesin, Anna Kline, Rachael Miller, Lauren St Hill, Miriam Latorre, Anton Shcherbakov, Arlene King, Barbara Stanley
Efforts to better understand and prevent suicide have increasingly pointed to the prospective assessment of suicidal behaviors in clinical trials. These assessments are aided by instruments such as the Columbia-Suicide Severity Rating Scale (C-SSRS), which have sought to improve the conceptual uniformity and ease by which suicidal behaviors are classified. At the same time, assessment and classification of suicidal behaviors has been a longtime challenge in the field. To aid users of the C-SSRS, this article illustrates the use of the C-SSRS in instances where classification complexities arise...
June 9, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
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