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https://www.readbyqxmd.com/read/28231581/prognostic-markers-and-histologic-subtypes-in-patients-with-meningeal-carcinomatosis-in-breast-cancer
#1
Hussein Alnajar, Lauren Rosen, Sara Javidiparsijani, Yahya Al-Ghamdi, Paolo Gattuso
OBJECTIVE: Meningeal carcinomatosis (MC) is a rare complication in breast cancer patients. It is defined as a diffuse or multifocal leptomeningeal metastasis. STUDY DESIGN: From our institution database, we retrospectively studied 19 patients diagnosed with MC in the cerebrospinal fluid (CSF) in 1997-2015, in order to evaluate tumor prognostic markers, histologic subtypes, and clinical outcome. RESULTS: All patients were female, with a mean age of 53 years (range 36-75 years)...
February 24, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28231418/exploring-human-papillomavirus-vaccination-refusal-among-ethnic-minorities-in-england-a-comparative-qualitative-study
#2
Alice S Forster, Lauren Rockliffe, Laura A V Marlow, Helen Bedford, Emily McBride, Jo Waller
OBJECTIVES: In England, uptake of human papillomavirus (HPV) vaccination to prevent HPV-related cancer is lower among girls from ethnic minority backgrounds. We aimed to explore the factors that prevented ethnic minority parents from vaccinating, compared to White British non-vaccinating parents and vaccinating ethnic minority parents. METHODS: Interviews with 33 parents (n = 14 ethnic minority non-vaccinating, n = 10 White British non-vaccinating, n = 9 ethnic minority vaccinating) explored parents' reasons for giving or withholding consent for HPV vaccination...
February 23, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28230615/the-effect-of-intravenous-acetaminophen-on-postoperative-pain-and-narcotic-consumption-after-vaginal-reconstructive-surgery-a-double-blind-randomized-placebo-controlled-trial
#3
Catrina C Crisp, Madiha Khan, Donna L Lambers, Lauren B Westermann, Donna M Mazloomdoost, Jennifer J Yeung, Steven D Kleeman, Rachel N Pauls
OBJECTIVE: This study aimed to determine the effect of intravenous acetaminophen versus placebo on postoperative pain, satisfaction with pain control, and narcotic use after vaginal reconstructive surgery. METHODS: This was an institutional review board-approved, double-blind placebo-controlled randomized trial. Women scheduled for reconstructive surgery including vaginal hysterectomy and vaginal vault suspension were enrolled. Subjects received 1000 mg of intravenous acetaminophen or 100 mL placebo every 6 hours for 24 hours...
March 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28230420/age-related-effects-on-memory-for-social-stimuli-the-role-of-valence-arousal-and-emotional-responses
#4
Thomas M Hess, Lauren E Popham, Claire M Growney
: Background/Study Context: Previous research (Hess et al., 2013, Psychology and Aging, 28, 853-863) suggested that age-based positivity effects in memory were attenuated with social stimuli. This research examined the degree to which this generalized across arousal levels associated with social images. Variations in approach and avoidance responses to individual images were also examined, along with age differences in their relationship to memory performance. METHODS: In Experiment 1, young (22-43 years) and older (65-85 years) adults recalled positive and negative social scenes that were high or low in arousal...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28230299/azido-and-tetrazolo-1-2-4-5-tetrazine-n-oxides
#5
David E Chavez, Damon A Parrish, Lauren Mitchell, Greg H Imler
This study presents the synthesis and characterization of the oxidation products of 3,6-diazido-1,2,4,5-tetrazine (1) and 6-amino-[1,5-b]tetrazolo-1,2,4,5-tetrazine (2). 3,6-Diazido-1,2,4,5-tetrazine-1,4-dioxide was produced from oxidation with peroxytrifluoroacetic acid, and more effectively using hypofluorous acid, and 2 can be oxidized to two different products, 6-amino-[1,5-b]tetrazolo-1,2,4,5-tetrazine mono-N-oxide and di-N-oxide. These N-oxide compounds display promising performance properties as energetic materials...
February 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28230242/routine-port-site-excision-in-incidentally-discovered-gallbladder-cancer-is-not-associated-with-improved-survival-a-multi-institution-analysis-from-the-us-extrahepatic-biliary-malignancy-consortium
#6
Cecilia G Ethun, Lauren M Postlewait, Nina Le, Timothy M Pawlik, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Kenneth Cardona, Shishir K Maithel
BACKGROUND: Current data on the utility of port-site excision (PSE) during re-resection for incidentally discovered gallbladder cancer (IGBC) in the US are conflicting and limited to single-institution series. METHODS: All patients with IGBC who underwent curative re-resection at 10 institutions from 2000 to 2015 were included. Patients with and without PSE were compared. Primary outcome was overall survival (OS). RESULTS: Of 449 pts with GBC, 266 were incidentally discovered, of which 193(73%) underwent curative re-resection and had port-site data; 47 pts(24%) underwent PSE, 146(76%) did not...
February 23, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28229518/transition-to-success-on-the-model-room-task-the-importance-of-improvements-in-working-memory
#7
Lauren E Hartstein, Neil E Berthier
Previous work has shown that children under age 3 often perform very poorly on the model room task, in which they are asked to find a hidden toy based on its location in a scale model. One prominent theory for their failure is that they lack the ability to understand the model as both a physical object and as a symbolic representation of the larger room. A hypothesized additional component is that they need to overcome weak, competing representations of where the object was on a previous trial, and where it is in the present trial, in order to succeed in their search...
February 22, 2017: Developmental Science
https://www.readbyqxmd.com/read/28229469/what-is-the-impact-of-shift-work-on-the-psychological-functioning-and-resilience-of-nurses-an-integrative-review
#8
REVIEW
Mozhdeh Tahghighi, Clare S Rees, Janie A Brown, Lauren J Breen, Desley Hegney
AIM: To synthesise existing research to determine if nurses who work shifts have poorer psychological functioning and resilience than nurses who do not work shifts. BACKGROUND: Research exploring the impact of shift work on the psychological functioning and resilience of nurses is limited compared with research investigating the impact of shifts on physical outcomes. DESIGN: Integrative literature review. DATA SOURCES: Relevant databases were searched from January 1995- August 2016 using the combination of keywords: nurse, shift work; rotating roster; night shift; resilient; hardiness; coping; well-being; burnout; mental health; occupational stress; compassion fatigue; compassion satisfaction; stress; anxiety; depression...
February 22, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28229187/-precursors-of-gastric-cancer-dysplasia-and-adenoma
#9
C Langner
Gastric cancer develops from preneoplastic and early neoplastic precursor lesions. In particular, the intestinal type according to the Lauren classification is driven by chronic inflammation and progresses via a chronic gastritis - atrophy/metaplasia - dysplasia - carcinoma sequence. Staging of the extent of atrophy (OLGA) or intestinal metaplasia (OLGIM) enables risk stratification and determines follow-up investigations according to the management of precancerous conditions and lesions in the stomach (MAPS) international guidelines...
February 22, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28229123/treatment-with-ledipasvir-sofosbuvir-for-hepatitis-c-resulting-in-improvement-of-lichen-planus
#10
Umer Ansari, Lauren I Henderson, Geraldine Stott, Karina Parr
No abstract text is available yet for this article.
January 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28229118/petechial-purpuric-and-ecchymotic-presentation-of-cutaneous-cryptococcus-in-mantle-cell-lymphoma
#11
Christie D Kimball, Allison Cruse, Lauren Craig, Joy King, Stephen Helms, Julie Wyatt, Jeremy Jackson, Robert Brodell
No abstract text is available yet for this article.
January 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28229066/a-case-of-influenza-a-h3n2-complicated-by-community-acquired-pneumonia-and-death-in-a-young-healthy-adult-during-the-2013-2014-season
#12
Lauren F Collins, Benjamin D Anderson, Gregory C Gray
With multiple available vaccines and antivirals, seasonal influenza A is typically a self-limited acutely debilitating illness in young healthy adults. Here, we illustrate unexpected morbidity and mortality in a relatively young and healthy patient seen at a large tertiary care academic medical center for seasonal influenza A (H3N2) complicated by community-acquired pneumonia, hypoxic respiratory failure, septic shock, and death.
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28228946/reward-and-punishment-sensitivity-and-disordered-eating-behaviors-in-men-and-women
#13
Kalina T Eneva, Susan Murray, Jared O'Garro-Moore, Angelina Yiu, Lauren B Alloy, Nicole M Avena, Eunice Y Chen
BACKGROUND: Reward and punishment sensitivities have been identified as potential contributors to binge eating and compensatory behaviors, though few studies have examined gender differences in these behaviors. METHOD: A college-aged sample (N = 1,022) completed both the Eating Disorders Diagnostic Scale (EDDS) and Sensitivity to Punishment/Sensitivity to Reward Questionnaire (SPSRQ). RESULTS: Rates of binge eating were similar in males and females...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28228502/the-sudden-death-in-the-young-case-registry-collaborating-to-understand-and-reduce-mortality
#14
Kristin M Burns, Lauren Bienemann, Lena Camperlengo, Carri Cottengim, Theresa M Covington, Heather Dykstra, Meghan Faulkner, Rosemarie Kobau, Alexa B Erck Lambert, Heather MacLeod, Sharyn E Parks, Ellen Rosenberg, Mark W Russell, Carrie K Shapiro-Mendoza, Esther Shaw, Niu Tian, Vicky Whittemore, Jonathan R Kaltman
Knowledge gaps persist about the incidence of and risk factors for sudden death in the young (SDY). The SDY Case Registry is a collaborative effort between the National Institutes of Health, the Centers for Disease Control and Prevention, and the Michigan Public Health Institute. Its goals are to: (1) describe the incidence of SDY in the United States by using population-based surveillance; (2) compile data from SDY cases to create a resource of information and DNA samples for research; (3) encourage standardized approaches to investigation, autopsy, and categorization of SDY cases; (4) develop partnerships between local, state, and federal stakeholders toward a common goal of understanding and preventing SDY; and (5) support families who have lost loved ones to SDY by providing resources on bereavement and medical evaluation of surviving family members...
February 22, 2017: Pediatrics
https://www.readbyqxmd.com/read/28228406/renal-inflammation-and-injury-is-associated-with-lymphangiogenesis-in-hypertension
#15
Sterling C Kneedler, Lauren E Phillips, Kayla R Hudson, Katharine M Beckman, Catalina A Lopez Gelston, Joseph M Rutkowski, Alan R Parrish, Peter A Doris, Brett M Mitchell
Lymphatic vessels are vital for the trafficking of immune cells from the interstitium to draining lymph nodes during inflammation. Hypertension is associated with renal infiltration of activated immune cells and inflammation, however it is unknown how renal lymphatic vessels change in hypertension. We hypothesized that renal macrophage infiltration and inflammation would cause increased lymphatic vessel density in hypertensive rats. Spontaneously hypertensive rats (SHR) that exhibit hypertension and renal injury (SHR-A3 strain) had significantly increased renal lymphatic vessel density and macrophages at 40 weeks of age compared to Wistar-Kyoto (WKY) controls...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28227974/heart-rate-variability-as-a-biomarker-for-sedation-depth-estimation-in-icu-patients
#16
Sunil B Nagaraj, Sowmya M Ramaswamy, Siddharth Biswal, Emily J Boyle, David W Zhou, Lauren M Mcclain, Eric S Rosenthal, Patrick L Purdon, M Brandon Westover, Sunil B Nagaraj, Sowmya M Ramaswamy, Siddharth Biswal, Emily J Boyle, David W Zhou, Lauren M Mcclain, Eric S Rosenthal, Patrick L Purdon, M Brandon Westover, M Brandon Westover, Sunil B Nagaraj, Siddharth Biswal, Sowmya M Ramaswamy, Lauren M Mcclain, David W Zhou, Emily J Boyle, Patrick L Purdon, Eric S Rosenthal
An automated patient-specific system to classify the level of sedation in ICU patients using heart rate variability signal is presented in this paper. ECG from 70 mechanically ventilated adult patients with administered sedatives in an ICU setting were used to develop a support vector machine based system for sedation depth monitoring using several heart rate variability measures. A leave-one-subject-out cross validation was used for classifier training and performance evaluations. The proposed patient-specific system provided a sensitivity, specificity and an AUC of 64%, 84...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226995/a-daytime-obstructive-sleep-apnea-severity-assessment-framework
#17
Lauren Samy, Paul M Macey, Majid Sarrafzadeh, Lauren Samy, Paul M Macey, Majid Sarrafzadeh, Majid Sarrafzadeh, Lauren Samy
Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by repeated episodes of complete or partial blockage of the upper airway. These episodes can interfere with sound sleep and have fatal health consequences. They can also reduce the flow of oxygen to vital organs, like the brain, and lead to brain damage. In this paper, we leverage the correlation between brain damage and OSA to design a prediction framework that can assess the severity level of the OSA condition, as well as estimate the Apnea-Hypopnea Index (AHI) using only features obtained during wakefulness...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225733/supporting-the-call-to-action-a-review-of-nutrition-educational-interventions-in-the-health-professions-literature-and-mededportal
#18
Timothy M Dang, Lauren A Maggio
PURPOSE: Despite calls to improve nutrition education, training for medical students is inadequate. This systematic review provides an overview of published educational interventions for undergraduate-level health professionals and makes recommendations for improving nutrition training. METHOD: The authors conducted a systematic review of articles (through July 16, 2015) and examined resources in MedEdPORTAL (through September 28, 2015) focused on materials published since January 2004 that describe nutrition educational interventions for undergraduate-level health professionals...
March 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28225601/rational-optimization-of-diphenyl-ether-binding-kinetics-to-the-enoyl-acp-reductase-fabi1-from-burkholderia-pseudomallei
#19
Carla Maya Neckles, Sandra Eltschkner, Jason Ellsworth Cummings, Maria Hirschbeck, Fereidoon Daryaee, Gopal R Bommineni, Zhuo Zhang, Lauren A Spagnuolo, Weixuan Yu, Shabnam Davoodi, Richard A Slayden, Caroline Kisker, Peter J Tonge
There is growing awareness of the link between drug-target residence time and in vivo drug activity, and there are increasing efforts to determine the molecular factors that control the lifetime of a drug-target complex. Rational alterations in drug-target residence time require knowledge of both the ground and transition states on the inhibition reaction coordinate, and we have determined the structure-kinetic relationship for 22 ethyl or hexyl substituted diphenyl ethers that are slow-binding inhibitors of bpFabI1, the enoyl-ACP reductase FabI1 from Burkholderia pseudomallei...
February 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28225587/compms2miner-an-automatable-metabolite-identification-visualization-and-data-sharing-r-package-for-high-resolution-lc-ms-datasets
#20
William Matthew Bell Edmands, Lauren M Petrick, Dinesh Kumar Barupal, Augustin Scalbert, Mark Wilson, Jeffrey Wickliffe, Stephen M Rappaport
A long-standing challenge of untargeted metabolomic profiling by ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) is efficient transition from unknown mass spectral features to confident metabolite annotations. The compMS2Miner (Comprehensive MS2 Miner) package was developed in the R language to facilitate rapid, comprehensive feature annotation using a peak-picker-output and MS2 data files as inputs. The number of MS2 spectra that can be collected during a metabolomic profiling experiment far outweigh the amount of time required for pain-staking manual interpretation, therefore a degree of software workflow autonomy is required for broad-scale metabolite annotation...
February 22, 2017: Analytical Chemistry
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