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https://www.readbyqxmd.com/read/29156671/conditional-survival-estimates-for-cancer-patients
#1
EDITORIAL
Lauren E Haydu, Richard A Scolyer, John F Thompson
No abstract text is available yet for this article.
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156136/the-discovery-of-3-4-chloro-3-methoxyphenyl-amino-1-3r-4s-4-cyanotetrahydro-2h-pyran-3-yl-1h-pyrazole-4-carboxamide-a-highly-ligand-efficient-and-efficacious-jak1-selective-inhibitor-with-favorable-pharmacokinetic-properties
#2
Tony Siu, Jason Brubaker, Peter Fuller, Luis Torres, Hongbo Zeng, Joshua Close, Dawn M Mampreian, Feng Shi, Duan Liu, Xavier Fradera, Kevin Johnson, Nathan Bays, Elma Kadic, Fang He, Peter Goldenblatt, Lynsey Shaffer, Sangita B Patel, Charles A Lesburg, Carla Alpert, Lauren Dorosh, Sujal V Deskmukh, Hongshi Yu, Joel Klappenbach, Fiona Elwood, Christopher J Dinsmore, Rafael Fernandez, Lily Moy, Jonathan R Young
The discovery of a potent selective low dose JAK1 inhibitor suitable for clinical evaluation is described. As part of an overall goal to minimize dose, we pursued a medicinal chemistry strategy focused on optimization of key parameters that influence dose size, including lowering human Clint and increasing intrinsic potency, bioavailability, and solubility. To impact these multiple parameters simultaneously, we used lipophilic ligand efficiency as a key metric to track changes in the physicochemical properties of our analogs, which led to improvements in overall compound quality...
November 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29156131/development-and-performance-characterization-of-a-polyimine-covalent-organic-framework-thin-film-composite-nanofiltration-membrane
#3
Lauren Valentino, Michio Matsumoto, William R Dichtel, Benito J Marinas
Two-dimensional covalent organic frameworks (COFs) were used to create the first asymmetric, thin-film composite (TFC) nanofiltration (NF) membrane with a COF active layer. NF membrane active layers of polyimine COF were synthesized via the interfacial polymerization (IP) of terephthalaldehyde and tris(4-aminophenyl)benzene monomers on top of a polyethersulfone (PES) ultrafiltration membrane support. Rutherford backscattering spectrometry and Fourier transform infrared spectroscopy analyses confirmed the presence of an imine-linked film with a thickness of ~10 nm that was formed reproducibly...
November 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29155845/effect-of-actigraph-s-low-frequency-extension-for-estimating-steps-and-physical-activity-intensity
#4
Yuri Feito, Lyndsey M Hornbuckle, Lauren A Reid, Scott E Crouter
This study examined the effects of the ActiGraph's (AG) low-frequency extension (LFE) filter on steps and physical activity classification in the free-living environment. Thirty-four African-American women (age, 24.5±5.2 years; BMI, 24.9±4.5 kg/m2) had daily activity measured simultaneously with an AG-GT3X+ accelerometer and a New Lifestyles NL-800 pedometer for seven days. Steps per day (steps/day) and time (minutes/day) spent in sedentary, light, and moderate-to-vigorous physical activity (MVPA) were examined with and without the LFE filter (AG-LFE and AG-N, respectively)...
2017: PloS One
https://www.readbyqxmd.com/read/29155081/population-receptive-field-prf-measurements-of-chromatic-responses-in-human-visual-cortex-using-fmri
#5
Lauren E Welbourne, Antony B Morland, Alex R Wade
The spatial sensitivity of the human visual system depends on stimulus color: achromatic gratings can be resolved at relatively high spatial frequencies while sensitivity to isoluminant color contrast tends to be more low-pass. Models of early spatial vision often assume that the receptive field size of pattern-sensitive neurons is correlated with their spatial frequency sensitivity - larger receptive fields are typically associated with lower optimal spatial frequency. A strong prediction of this model is that neurons coding isoluminant chromatic patterns should have, on average, a larger receptive field size than neurons sensitive to achromatic patterns...
November 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/29154779/letrozole-pre-treatment-prior-to-medical-termination-of-pregnancy-a-systematic-review
#6
Christopher M Nash, Lauren Philp, Prakesh Shah, Kellie E Murphy
OBJECTIVE(S): The purpose of this systematic review was to evaluate the efficacy of pretreatment with letrozole prior to either a first or second trimester medical termination of pregnancy. STUDY DESIGN: We searched letrozole, femara, aromatase inhibitors, abortifacient agents, termination of pregnancy, and labour induction in MEDLINE, EMBASE, Cochrane Database, Google Scholar, and PubMed from inception of each database until September 2015 with no language limitation...
November 14, 2017: Contraception
https://www.readbyqxmd.com/read/29154575/metamethod-study-of-qualitative-psychotherapy-research-on-clients-experiences-review-and-recommendations
#7
Heidi M Levitt, Andrew Pomerville, Francisco I Surace, Lauren M Grabowski
A metamethod study is a qualitative meta-analysis focused upon the methods and procedures used in a given research domain. These studies are rare in psychological research. They permit both the documentation of the informal standards within a field of research and recommendations for future work in that area. This paper presents a metamethod analysis of a substantial body of qualitative research that focused on clients' experiences in psychotherapy (109 studies). This review examined the ways that methodological integrity has been established across qualitative research methods...
November 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29154364/non-contingent-exposure-to-amphetamine-in-adolescence-recruits-mir-218-to-regulate-dcc-expression-in-the-vta
#8
Santiago Cuesta, José Maria Restrepo-Lozano, Steven Silvestrin, Dominique Nouel, Angélica Torres-Berrio, Lauren M Reynolds, Andreas Arvanitogiannis, Cecilia Flores
The development of the dopamine input to the medial prefrontal cortex occurs during adolescence and is a process that is vulnerable to disruption by stimulant drugs such as amphetamine. We have previously linked the amphetamine-induced disruption of dopamine connectivity and prefrontal cortex maturation during adolescence to the downregulation of the Netrin-1 receptor, DCC, in dopamine neurons. However, how DCC expression in dopamine neurons is itself regulated is completely unknown. MicroRNA (miRNA) regulation of mRNA translation and stability is a prominent mechanism linking environmental events to changes in protein expression...
November 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29154152/a-mathematical-model-to-plan-for-long-term-effects-of-water-conservation-choices-on-dry-weather-wastewater-flows-and-concentrations
#9
Lauren M Cook, Constantine Samaras, Jeanne M VanBriesen
In many cities, sewer systems are experiencing conditions that are significantly different from those for which they were designed. Factors such as water conservation efforts, changes in population, and efforts to reduce infiltration are altering the quantity and quality of sewage. These changes may affect the ability of sewers to maintain self-cleansing velocities, which are crucial to avoiding solids settling and corrosion issues. Further, such changes may alter the timeline for expected wastewater plant expansion...
November 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29154150/exposure-to-tobacco-websites-associations-with-cigarette-and-e-cigarette-use-and-susceptibility-among-adolescents
#10
Jennifer B Unger, Lauren Bartsch
INTRODUCTION: Exposure to tobacco advertising is a risk factor for tobacco use and susceptibility among adolescents. Although tobacco company websites are ostensibly targeted to adults, some youth access these websites and are exposed to tobacco-related content. METHODS: This study analyzed data from the Population Assessment of Tobacco and Health (PATH) survey to estimate the prevalence of exposure to tobacco websites and the associations between website exposure and tobacco product use and susceptibility among adolescents in the United States...
November 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29154132/dexmedetomidine-promotes-biomimetic-non-rapid-eye-movement-stage-3-sleep-in-humans-a-pilot-study
#11
Oluwaseun Akeju, Lauren E Hobbs, Lei Gao, Sara M Burns, Kara J Pavone, George S Plummer, Elisa C Walsh, Tim T Houle, Seong-Eun Kim, Matt T Bianchi, Jeffrey M Ellenbogen, Emery N Brown
OBJECTIVES: Sleep, which comprises of rapid eye movement (REM) and non-REM stages 1-3 (N1-N3), is a natural occurring state of decreased arousal that is crucial for normal cardiovascular, immune and cognitive function. The principal sedative drugs produce electroencephalogram beta oscillations, which have been associated with neurocognitive dysfunction. Pharmacological induction of altered arousal states that neurophysiologically approximate natural sleep, termed biomimetic sleep, may eliminate drug-induced neurocognitive dysfunction...
October 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29153873/comparison-of-behavioural-activation-with-guided-self-help-for-treatment-of-depression-in-adults-with-intellectual-disabilities-a-randomised-controlled-trial
#12
Andrew Jahoda, Richard Hastings, Chris Hatton, Sally-Ann Cooper, Dave Dagnan, Ruiqi Zhang, Alex McConnachie, Nicola McMeekin, Kim Appleton, Rob Jones, Katie Scott, Lauren Fulton, Rosie Knight, Dawn Knowles, Chris Williams, Andrew Briggs, Ken MacMahon, Helen Lynn, Ian Smith, Gail Thomas, Craig Melville
BACKGROUND: Psychological therapies are first-line interventions for depression, but existing provision is not accessible for many adults with intellectual disabilities. We investigated the clinical and cost-effectiveness of a behavioural activation intervention (BeatIt) for people with intellectual disabilities and depression. BeatIt was compared with a guided self-help intervention (StepUp). METHODS: We did a multicentre, single-blind, randomised, controlled trial with follow-up at 4 months and 12 months after randomisation...
November 13, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/29153864/changes-in-markers-of-thrombin-generation-and-interleukin-6-during-unicondylar-knee-and-total-knee-arthroplasty
#13
Edwin P Su, Lauren E Mount, Allina A Nocon, Thomas P Sculco, George Go, Nigel E Sharrock
BACKGROUND: Total knee arthroplasty (TKA) is associated with a risk of thromboembolism requiring routine thromboprophylaxis, but there is debate about the risk with unicondylar knee arthroplasty (UKA) as it is a more minor procedure. We sought to investigate the relative risk of thromboembolism with UKA compared to TKA and one-staged bilateral TKA (BTKA) by measuring the increase in circulating biochemical markers of thrombin generation during the procedures. Degree of surgical trauma was also assessed by measuring interleukin-6, a marker of metabolic injury...
October 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29153658/neurological-function-in-children-born-to-preeclamptic-and-hypertensive-mothers-a-systematic-review
#14
REVIEW
Ernesto A Figueiró-Filho, Lauren E Mak, James N Reynolds, Patrick W Stroman, Graeme N Smith, Nils D Forkert, Angelina Paolozza, Matthew T Rätsep, B Anne Croy
BACKGROUND: Offspring whose mothers developed preeclampsia (PE-F1s) show developmental effects that are now being identified, such as cognitive, behavioural, and mood differences compared to offspring from non-complicated pregnancies. We hypothesize that the progressive angiokine dysregulation associated with development of preeclampsia (PE) reflects gene dysregulation in pre-implantation conceptuses, and manifests in all developing fetal tissues rather than exclusively to the placenta...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153506/role-of-non-local-interactions-between-cdr-loops-in-binding-affinity-of-mr78-antibody-to-marburg-virus-glycoprotein
#15
Amandeep K Sangha, Jinhui Dong, Lauren Williamson, Takao Hashiguchi, Erica Ollmann Saphire, James E Crowe, Jens Meiler
An atomic-detail model of the Marburg virus glycoprotein in complex with a neutralizing human monoclonal antibody designated MR78 was constructed using Phenix.Rosetta starting from a 3.6Å crystallographic density map. The Asp at T6 in the HCDR3's bulged torso cannot form the canonical salt bridge as position T2 lacks an Arg or Lys residue. It instead engages in a hydrogen bond interaction with a Tyr contributed by the HCDR1 loop. This inter-CDR loop interaction stabilizes the bulged conformation needed for binding to the viral glycoprotein: a Tyr to Phe mutant displays a binding affinity reduced by a factor of at least 10...
November 14, 2017: Structure
https://www.readbyqxmd.com/read/29153473/sensitivity-of-the-early-life-stages-of-a-mayfly-to-fine-sediment-and-orthophosphate-levels
#16
Nicholas C Everall, Matthew F Johnson, Paul Wood, Lauren Mattingley
The ecological effects of interacting stressors within lotic ecosystems have been widely acknowledged. In particular, the ecological effects of elevated fine sediment inputs and phosphate have been identified as key factors influencing faunal community structure and composition. However, while knowledge regarding adult and larval life stage responses to environmental stressors has grown, there has been very limited research on their eggs. In this study, the eggs of the mayfly Serratella ignita (Ephemerellidae: Ephemeroptera) were collected and incubated in laboratory aquaria to hatching under differing concentrations of inert suspended sediment (SS) and orthophosphate (OP), individually and in combination...
November 15, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29153057/sex-dependent-influence-of-developmental-toxicant-exposure-on-group-b-streptococcus-mediated-preterm-birth-in-a-murine-model
#17
Tianbing Ding, Lauren A Lambert, David M Aronoff, Kevin G Osteen, Kaylon L Bruner-Tran
Infectious agents are a significant risk factor for preterm birth (PTB); however, the simple presence of bacteria is not sufficient to induce PTB in most women. Human and animal data suggest that environmental toxicant exposures may act in concert with other risk factors to promote PTB. Supporting this "second hit" hypothesis, we previously demonstrated exposure of fetal mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to an increased risk of spontaneous and infection-mediated PTB in adult animals...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29152566/radiocarbon-chronology-of-manot-cave-israel-and-upper-paleolithic-dispersals
#18
Bridget Alex, Omry Barzilai, Israel Hershkovitz, Ofer Marder, Francesco Berna, Valentina Caracuta, Talia Abulafia, Lauren Davis, Mae Goder-Goldberger, Ron Lavi, Eugenia Mintz, Lior Regev, Daniella Bar-Yosef Mayer, José-Miguel Tejero, Reuven Yeshurun, Avner Ayalon, Mira Bar-Matthews, Gal Yasur, Amos Frumkin, Bruce Latimer, Mark G Hans, Elisabetta Boaretto
The timing of archeological industries in the Levant is central for understanding the spread of modern humans with Upper Paleolithic traditions. We report a high-resolution radiocarbon chronology for Early Upper Paleolithic industries (Early Ahmarian and Levantine Aurignacian) from the newly excavated site of Manot Cave, Israel. The dates confirm that the Early Ahmarian industry was present by 46,000 calibrated years before the present (cal BP), and the Levantine Aurignacian occurred at least between 38,000 and 34,000 cal BP...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29152235/serum-25-hydroxyvitamin-d3-and-24r-25-dihydroxyvitamin-d3-concentrations-in-adult-dogs-are-more-substantially-increased-by-oral-supplementation-of-25-hydroxyvitamin-d3-than-by-vitamin-d3
#19
Lauren R Young, Robert C Backus
We previously found a weak response in serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations when dogs were supplemented with oral vitamin D3 (D3). In the present study, we determined the relative potency of oral 25(OH)D3 compared with D3 for increasing vitamin D status in dogs with low serum 25(OH)D concentrations. Four male and three female, 4-year-old, intact, lean, genetically related, Chinese-crested/beagle dogs were studied in a randomised, single cross-over trial. After feeding a low-vitamin D diet (<4 IU/100 g) for 30 d, four dogs received daily D3 supplementation at 2·3 µg/kg body weight(0·75), while three dogs received a molar equivalency as 25(OH)D3...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29152202/assessing-the-potential-of-translocating-vulnerable-forest-birds-by-searching-for-novel-and-enduring-climatic-ranges
#20
Lucas B Fortini, Lauren R Kaiser, Adam E Vorsino, Eben H Paxton, James D Jacobi
Hawaiian forest birds are imperiled, with fewer than half the original >40 species remaining extant. Recent studies document ongoing rapid population decline and project complete climate-based range losses for the critically endangered Kaua'i endemics 'akeke'e (Loxops caeruleirostris) and 'akikiki (Oreomystis bairdi) by end-of-century due to projected warming. Climate change facilitates the upward expansion of avian malaria into native high elevation forests where disease was historically absent. While intensified conservation efforts attempt to safeguard these species and their habitats, the magnitude of potential loss and the urgency of this situation require all conservation options to be seriously considered...
November 2017: Ecology and Evolution
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