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https://www.readbyqxmd.com/read/29024334/intermediate-and-nonclassical-monocytes-show-heterogeneity-in-patients-with-different-types-of-acute-coronary-syndrome
#1
Math P G Leers, Chantal Stockem, Dianne Ackermans, Rinske Loeffen, Hugo Ten Cate, Johannes A Kragten, Kon-Siong G Jie
This study was performed to gain further insight in the heterogeneity of monocytes in the different categories of acute coronary syndrome (ACS), especially between patients with unstable angina pectoris, ST-elevation myocardial infarction (STEMI), and non-ST-elevation myocardial infarction (NSTEMI). For this purpose, blood samples were collected in the acute phase from patients presenting with an ACS. These samples were examined with multiparameter flow cytometry to identify the different monocyte subsets and to analyze the expression of monocyte-associated molecules...
October 11, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29023996/effect-of-sex-difference-in-clinical-presentation-stable-coronary-artery-disease-vs-unstable-angina-pectoris-or-non-st-elevation-myocardial-infarction-vs-st-elevation-myocardial-infarction-on-2-year-outcomes-in-patients-undergoing-percutaneous-coronary-intervention
#2
Xiao-Fang Tang, Ying Song, Jing-Jing Xu, Yuan-Liang Ma, Jia-Hui Zhang, Yi Yao, Chen He, Huan-Huan Wang, Ping Jiang, Lin Jiang, Ru Liu, Zhan Gao, Xue-Yan Zhao, Shu-Bin Qiao, Bo Xu, Yue-Jin Yang, Run-Lin Gao, Jin-Qing Yuan
OBJECTIVE: To determine whether there is a difference in 2-year prognosis among patients across the spectrum of coronary artery disease undergoing percutaneous coronary intervention (PCI). METHODS: We analyzed all consecutive patients undergoing PCI at a single center from 1/1-12/31/2013. Clinical presentations were compared between sexes according to baseline clinical, angiographic, and procedural characteristics and 2-year (mean 730 ± 30-day) outcomes. RESULTS: We grouped 10 724 consecutive patients based on sex and clinical presentation...
October 11, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29019519/unusually-aggressive-immature-neo-intimal-hyperplasia-causing-in-stent-restenosis
#3
Keir McCutcheon, Andreas S Triantafyllis, Johan Bennett, Tom Adriaenssens
This image illustrates a very unusual pattern of early and aggressive immature neo-intimal hyperplasia in a 52-year-old man with unstable angina, two months after deployment of a drug-eluting stent in the proximal left anterior descending artery.
October 10, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29019280/social-inequality-and-barriers-to-cardiac-rehabilitation-in-the-rehab-north-register
#4
Christina Boesgaard Graversen, Regina Eichhorst, Lisbeth Ravn, Susanne Svane Riis Christiansen, Martin Berg Johansen, Mogens Lytken Larsen
AIM: Barriers to participation in cardiac rehabilitation (CR) may occur at three levels of the referral process (lack of information, declining to participate, and referral to appropriate CR programme). The aim is to analyse the impact of socioeconomic status on barriers to CR and investigate whether such barriers influenced the choice of referral. METHODS: The Rehab-North Register, a cross-sectional study, enrolled 5455 patients hospitalised at Aalborg University Hospital with myocardial infarction (MI) during 2011-2014...
October 11, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28992985/apoa1-and-apob-polymorphisms-and-apolipoprotein-concentrations-as-biomarkers-of-risk-in-acute-coronary-syndrome-relationship-with-lipid-lowering-therapy-effectiveness
#5
Fidel Casillas-Muñoz, Yeminia Valle, José Francisco Muñoz-Valle, Diana Emilia Martínez-Fernández, Gabriela Lizet Reynoso-Villalpando, Héctor Enrique Flores-Salinas, Mara Anaís Llamas-Covarrubias, Jorge Ramón Padilla-Gutiérrez
BACKGROUND AND OBJECTIVE: Lipid metabolism alterations contribute to acute coronary syndrome (ACS). rs670, rs5070 and rs693 polymorphisms have shown to modify the risk of cardiovascular disease. Apolipoprotein A-I (ApoA-I) plays a major role in reverse cholesterol transport; apolipoprotein B (ApoB) contributes to accumulation of cholesterol in the plaque. The aim of this study was to investigate the association of rs670 and rs5070 polymorphisms of APOA1 and rs693 polymorphism of APOB with ACS and circulating levels of its proteins and find if ApoB/ApoA-I could be implemented as an independent parameter of risk for cardiovascular disease and as a biomarker of lipid-lowering therapy effectiveness in Mexican population...
October 6, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28990946/stent-and-implantable-cardioverter-defibrillator-implantation-in-medically-resistant-vasospastic-angina-patient
#6
Nil Özyüncü, Hüseyin Göksülük, Veysel Kutay Vurgun, Onur Yıldırım, Türkan Seda Tan Kürklü
Vasospastic angina, also known as Prinzmetal's angina, is thought to occur due to vascular hyper-reactivity to various stimuli. Response to medical therapy is usually good; however, 1 out of 5 patients has resistant symptoms. Rarely, potentially lethal arrhythmias can occur due to vasospasm, and those patients are reported to have a poorer prognosis. Presently described is a case of resistant vasospastic angina with persistent symptoms under calcium channel blocker and nitrate treatment. The patient presented with hemodynamically unstable rapid-rate ventricular tachycardia, which was quite resistant to recurrent cardioversion...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28986773/feasibility-of-combined-risk-stratification-with-coronary-ct-angiography-and-stress-myocardial-spect-in-patients-with-chronic-coronary-artery-disease
#7
Tomonari Kiriyama, Yoshimitsu Fukushima, Hiromitsu Hayashi, Hitoshi Takano, Shin-Ichiro Kumita
OBJECTIVE: To examine the additional prognostic value of coronary CT angiography (CTA) over myocardial perfusion imaging (MPI) in patients with suspected or known coronary artery disease. METHODS: A series of 157 patients (mean age 69 ± 9 years; 76% male; median follow-up 49 months; range 12-82 months) underwent stress MPI with SPECT and coronary CTA within a 6-month interval. Summed stress score (SSS) and summed difference score (SDS) of stress MPI, number of vessels with stenosis, and presence of left main trunk stenosis and high-risk plaques on coronary CTA were examined...
October 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28985265/health-related-quality-of-life-in-older-patients-with-acute-coronary-syndrome-randomised-to-an-invasive-or-conservative-strategy-the-after-eighty-randomised-controlled-trial
#8
Nicolai Tegn, Michael Abdelnoor, Lars Aaberge, Anette Hylen Ranhoff, Knut Endresen, Erik Gjertsen, Rita Skårdal, Lars Gullestad, Bjørn Bendz
Objective: in the After Eighty study (ClinicalTrials.gov.number, NCT01255540), patients aged 80 years or more, with non-ST-elevation myocardial infarction (NSTEMI), and unstable angina pectoris (UAP), were randomised to either an invasive or conservative management approach. We sought to compare the effects of these management strategies on health related quality of life (HRQOL) after 1 year. Methods: the After Eighty study was a prospective randomised controlled multicenter trial...
July 13, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28974662/outcomes-of-patients-with-a-history-of-coronary-artery-bypass-grafting-who-underwent-orbital-atherectomy-for-severe-coronary-artery-calcification
#9
Michael S Lee, Evan Shlofmitz, Arash Nayeri, John Hollowed, Richard A Shlofmitz
OBJECTIVE: We assess the angiographic and clinical outcomes of patients with a history of coronary artery bypass graft (CABG) surgery who underwent orbital atherectomy for the treatment of severely calcified coronary lesions. BACKGROUND: The presence of severe coronary artery calcification (CAC) increases the complexity of percutaneous coronary intervention (PCI) and is associated with worse clinical outcomes. Patients with a history of CABG who undergo PCI often have comorbidities and are at higher risk for ischemic complications...
October 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28966444/percutaneous-coronary-intervention-and-inpatient-mortality-in-patients-with-advanced-chronic-kidney-disease-presenting-with-acute-coronary-syndrome
#10
Brijesh Patel, Mahek Shah, Raman Dusaj, Sharon Maynard, Nainesh Patel
Chronic kidney disease (CKD) is an important risk factor for coronary artery disease, yet patients with CKD are less likely to undergo coronary angiography and percutaneous coronary intervention (PCI). We retrospectively analyzed the 2006-2012 National Inpatient Sample Database to examine the temporal trends in coronary angiography and PCI among patients without CKD, with advanced CKD (CKD III-V), and with end-stage renal disease (ESRD) presenting with unstable angina/non-ST elevation myocardial infarction (NSTE-ACS) and ST-elevation myocardial infarction (STEMI)...
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28965096/effect-of-weekend-admission-on-process-of-care-and-clinical-outcomes-for-the-management-of-acute-coronary-syndromes-a-retrospective-analysis-of-three-uk-centres
#11
Glen P Martin, Tim Kinnaird, Matthew Sperrin, Richard Anderson, Amr Gamal, Avais Jabbar, Chun Shing Kwok, Diane Barker, Grant Heatlie, Azfar G Zaman, Mamas A Mamas
OBJECTIVES: The effect of weekend versus weekday admission following acute coronary syndrome (ACS) on process of care and mortality remains controversial. This study aimed to investigate the 'weekend-effect' on outcomes using a multicentre dataset of patients with ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction/unstable angina (NSTEMI/UA). DESIGN: This retrospective observational study used propensity score (PS) stratification to adjust estimates of weekend effect for observed confounding...
September 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28961259/elevated-plasma-mirna-122-140-3p-720-2861-and-3149-during-early-period-of-acute-coronary-syndrome-are-derived-from-peripheral-blood-mononuclear-cells
#12
Xiang-Dong Li, Yue-Jin Yang, Lai-Yuan Wang, Shu-Bin Qiao, Xiang-Feng Lu, Yong-Jian Wu, Bo Xu, Hong-Fan Li, Dong-Feng Gu
OBJECTIVE: Our previous study has found that circulating microRNA (miRNA, or miR) -122, -140-3p, -720, -2861, and -3149 are significantly elevated during early stage of acute coronary syndrome (ACS). This study was conducted to determine the origin of these elevated plasma miRNAs in ACS. METHODS: qRT-PCR was performed to detect the expression profiles of these 5 miRNAs in liver, spleen, lung, kidney, brain, skeletal muscles, and heart. To determine their origins, these miRNAs were detected in myocardium of acute myocardial infarction (AMI), and as well in platelets and peripheral blood mononuclear cells (PBMCs, including monocytes, circulating endothelial cells (CECs) and lymphocytes) of the AMI pigs and ACS patients...
2017: PloS One
https://www.readbyqxmd.com/read/28958142/serum-25-hydroxy-vitamin-d-concentration-in-acute-coronary-syndrome
#13
E Anastasi, M Suppa, V Viggiani, S Tartaglione, A Angeloni, T Granato
Vitamin D may have prognostic value in cardiovascular disease (CVD) patients and, in addition to conventional biomarkers, could be a valuable tool for disease management. The aim of this study was to assess the association of vitamin D status in patients with acute coronary syndrome (ACS) and to evaluate its prognostic utility. The levels of 25(OH) vitamin D were correlated with troponin T hs. Forty-eight consecutive outpatients (40 Caucasian and 8 Asian) aged between 40 and 70 years (mean 61.5, range 43-77 years) were enrolled in the study...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28950317/the-association-of-depression-at-any-time-to-the-risk-of-death-following-coronary-artery-disease-diagnosis
#14
Heidi T May, Benjamin D Horne, Stacey Knight, Kirk U Knowlton, Tami L Bair, Donald L Lappé, Viet T Le, Joseph B Muhlestein
Aims: Depression is a risk factor for cardiovascular (CV) diseases, incident CV events, and mortality. Among individuals who experience a CV diagnosis or event, whether a subsequent diagnosis of depression is associated with a greater risk of mortality is unknown. Among patients with existing coronary artery disease (CAD), this study evaluated the association of a subsequent depression diagnosis with all-cause mortality. Methods and Results: Patients (N = 24,137) who had angiographically determined CAD (stenosis ≥70%) were studied...
July 26, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28950314/prognostic-impact-of-unrecognized-myocardial-scar-in-the-non-culprit-territories-by-cardiac-magnetic-resonance-imaging-in-patients-with-acute-myocardial-infarction
#15
Taku Omori, Tairo Kurita, Kaoru Dohi, Akihiro Takasaki, Tomoyuki Nakata, Shiro Nakamori, Naoki Fujimoto, Kakuya Kitagawa, Kozo Hoshino, Takashi Tanigawa, Hajime Sakuma, Masaaki Ito
Aims: Unrecognized myocardial scar by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) is strongly associated with cardiac event in patients with stable coronary artery disease. The purpose of this study was to evaluate the prognostic impact of unrecognized non-infarct-related LGE (non-IR-LGE) in patients with acute myocardial infarction (AMI). Methods and results: We studied 269 patients with a first clinical episode of AMI underwent cardiac MRI within 6 weeks after onset (209 men; age, 66 ± 12 years)...
July 27, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28947562/magnitude-and-characteristics-of-patients-who-survived-an-acute-myocardial-infarction
#16
Mayra Tisminetzky, Tracy Y Wang, Jerry Gurwitz, Lisa A Kaltenbach, David McManus, Joel Gore, Eric Peterson, Robert J Goldberg
BACKGROUND: The purpose of this study was to describe the magnitude and characteristics of patients who did not experience any significant major adverse cardiovascular event early (within 6 weeks) and late (during the first year) after hospital discharge for an acute myocardial infarction (AMI). METHODS AND RESULTS: Data from 12 243 patients discharged after an AMI from 233 sites across the United States in the TRANSLATE-ACS (Treatment With ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) study were analyzed...
September 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28940292/different-patients-different-outcomes-a-case-control-study-of-spontaneous-coronary-artery-dissection-versus-acute-coronary-syndrome
#17
Heath Adams, Elizabeth Paratz, Jithendra Somaratne, Jamie Layland, Andrew Burns, Sonny Palmer, Andrew MacIsaac, Robert Whitbourn
INTRODUCTION: There is progressive interest worldwide in spontaneous coronary artery dissection (SCAD). To identify a SCAD cohort and compare risk factors, presentation, and management outcomes compared to acute coronary syndrome (ACS) matched controls. METHODS: Retrospective analysis was performed from 2000 to 2015. Clinical data included a neuropsychiatric history, with management and clinical outcomes assessed at 12 months. Patients were matched on a 1:3 case-control basis according to type of ACS...
September 20, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28927706/cardiovascular-safety-and-efficacy-of-the-pcsk9-inhibitor-evolocumab-in-patients-with-and-without-diabetes-and-the-effect-of-evolocumab-on-glycaemia-and-risk-of-new-onset-diabetes-a-prespecified-analysis-of-the-fourier-randomised-controlled-trial
#18
Marc S Sabatine, Lawrence A Leiter, Stephen D Wiviott, Robert P Giugliano, Prakash Deedwania, Gaetano M De Ferrari, Sabina A Murphy, Julia F Kuder, Ioanna Gouni-Berthold, Basil S Lewis, Yehuda Handelsman, Armando Lira Pineda, Narimon Honarpour, Anthony C Keech, Peter S Sever, Terje R Pedersen
BACKGROUND: The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab reduced LDL cholesterol and cardiovascular events in the FOURIER trial. In this prespecified analysis of FOURIER, we investigated the efficacy and safety of evolocumab by diabetes status and the effect of evolocumab on glycaemia and risk of developing diabetes. METHODS: FOURIER was a randomised trial of evolocumab (140 mg every 2 weeks or 420 mg once per month) versus placebo in 27 564 patients with atherosclerotic disease who were on statin therapy, followed up for a median of 2·2 years...
September 14, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28926377/sequential-and-urgent-coronary-artery-bypass-surgery-followed-by-kidney-transplantation-in-a-highly-sensitized-patient-with-unstable-angina
#19
Han Yao, Mark Smilovitch, Renzo Cerere, Shaifali Sandal, Steven Paraskevas, Dana Baran, Maria Helena Calixto Fernandes, Chee Loong Saw, Jean Tchervenkov, Marcelo Cantarovich
No abstract text is available yet for this article.
September 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28925859/effects-of-evolocumab-on-cardiovascular-events
#20
Nasser Mikhail
BACKGROUND: Evolocumab is a potent lipid-lowering drug that decreases plasma levels of low-density lipoprotein cholesterol (LDL-C) by 50-60%. FOURIER is a landmark randomized, trial involving 27,564 patients with established cardiovascular disease already on statins and plasma LDL-C levels > 70 mg/dl. OBJECTIVE: the main objective of FOURIER was to examine the effects of evolocumab on cardiovascular events. RESULTS: After a mean follow-up of 2...
September 18, 2017: Current Cardiology Reviews
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