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https://www.readbyqxmd.com/read/27921196/danshen-injection-as-adjuvant-treatment-for-unstable-angina-pectoris-a-systematic-review-and-meta-analysis
#1
Jia-Rui Wu, Shi Liu, Xiao-Meng Zhang, Bing Zhang
OBJECTIVE: To systematically evaluate the clinical effectiveness and safety of Danshen Injection (, DS) as one adjuvant treatment for conventional therapy with Western medicine (WM) for unstable angina pectoris (UAP). METHODS: Using literature databases, a thorough and systematic retrieval of randomized controlled trials (RCTs) comparing DS plus WM with WM was conducted from inception to April 2015. The extracted data from included studies was analyzed by Review Manager 5...
December 5, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27914504/on-treatment-analysis-of-the-improved-reduction-of-outcomes-vytorin-efficacy-international-trial-improve-it
#2
Michael A Blazing, Robert P Giugliano, James A de Lemos, Christopher P Cannon, Andrew Tonkin, Christie M Ballantyne, Basil S Lewis, Thomas A Musliner, Andrew M Tershakovec, Yuliya Lokhnygina, Jennifer A White, Craig Reist, Amy McCagg, Eugene Braunwald
BACKGROUND: We aimed to determine the efficacy and safety of adding ezetimibe (Ez) to simvastatin (S) in a post-acute coronary syndrome (ACS) population in a prespecified on-treatment analysis. METHODS: We evaluated 17,706 post-ACS patients from the IMPROVE-IT trial who had low-density lipoprotein cholesterol values between 50 and 125 mg/dL and who received Ez 10 mg/d with S 40 mg/d (Ez/S) or placebo with simvastatin 40 mg/d (P/S). The primary composite end point was cardiovascular death, myocardial infarction, unstable angina, coronary revascularization ≥30 days postrandomization, or stroke...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27914502/rationale-and-design-of-the-progression-of-atherosclerotic-plaque-determined-by-computed-tomographic-angiography-imaging-paradigm-registry-a-comprehensive-exploration-of-plaque-progression-and-its-impact-on-clinical-outcomes-from-a-multicenter-serial-coronary
#3
Sang-Eun Lee, Hyuk-Jae Chang, Asim Rizvi, Martin Hadamitzky, Yong-Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Valentina Volpato, Matthew J Budoff, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Jonathon A Leipsic, Sanghoon Shin, Jung Hyun Choi, Namsik Chung, James K Min
BACKGROUND: The natural history of coronary artery disease (CAD) in patients with low-to-intermediate risk is not well characterized. Although earlier invasive serial studies have documented the progression of atherosclerotic burden, most were focused on high-risk patients only. The PARADIGM registry is a large, prospective, multinational dynamic observational registry of patients undergoing serial coronary computed tomographic angiography (CCTA). The primary aim of PARADIGM is to characterize the natural history of CAD in relation to clinical and laboratory data...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27912210/relative-contributions-of-arterial-stiffness-and-hypertension-to-cardiovascular-disease-the-framingham-heart-study
#4
Teemu J Niiranen, Bindu Kalesan, Naomi M Hamburg, Emelia J Benjamin, Gary F Mitchell, Ramachandran S Vasan
BACKGROUND: The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of blood pressure. METHODS AND RESULTS: We measured carotid-femoral pulse wave velocity (PWV) and classical CVD risk factors in 2127 community-dwelling participants (mean age 60 years, 57% women) of The Framingham Offspring Cohort...
October 26, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27904510/correlation-between-plasma-angiopoietin-1-angiopoietin-2-and-matrix-metalloproteinase-2-in-coronary-heart-disease
#5
Haoyu Wu, Xiling Shou, Lei Liang, Congxia Wang, Xiaowei Yao, Gong Cheng
INTRODUCTION: Angiopoietin-2 (Ang-2) plays a critical role in inducing tumor cell infiltration, and this invasive phenotype is caused by up-regulation of matrix metalloproteinase (MMP)-2. The relationship between Ang-2 and MMP-2 in atherosclerosis has not been reported yet. The aim is to measure the plasma concentrations of Ang-1, Ang-2 and MMP-2 and assess the correlation between the concentrations of these factors in coronary heart disease (CHD) patients. MATERIAL AND METHODS: The testing was done in a cross-sectional study...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27900349/symptomatic-bilateral-coronary-artery-fistula-to-pulmonary-artery-in-elderly-patient
#6
Francisco Pereira da Silva, Paulo Donato, Henrique Donato, Elisabete Jorge, Maria Joao Ferreira, Filipe Caseiro-Alves
We report the imaging findings of an uncommon coronary vascular termination anomaly, with fistula to the pulmonary artery. This 70 year old female patient presented unstable angina, showing a coronary artery fistula depicted in coronary angiogram from the left coronary to the pulmonary artery, with no significant atherosclerotic pathology. Due to development of ventricular tachycardia in stress echocardiogram examination, she was proposed for coronary fistula closure. Coronary CT was performed for procedure planning and allowed the identification of a second unsuspected fistula from the right coronary to the right pulmonary artery...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27896897/expanded-clinical-use-of-everolimus-eluting-bioresorbable-vascular-scaffolds-for-treatment-of-coronary-artery-disease
#7
Roberto Diletti, Yuki Ishibashi, Cordula Felix, Yoshinobu Onuma, Shimpei Nakatani, Nicolas M van Mieghem, Eveliyn Regar, Marco Valgimigli, Peter P de Jaegere, Nienke van Ditzhuijzen, Jiang Ming Fam, Jurgen M R Ligthart, Mattie J Lenzen, Patrick W Serruys, Felix Zijlstra, Robert Jan van Geuns
BACKGROUND: Limited data are currently available on the performance of everolimus eluting bioresorbable vascular scaffold (BVS) for treatment of complex coronary lesions representative of daily practice. METHODS: This is a prospective, mono-center, single-arm study, reporting data after BVS implantation in patients presenting with stable, unstable angina, or non-ST segment elevation myocardial infarction caused by de novo stenotic lesions in native coronary arteries...
November 29, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27892881/comparison-of-visual-assessment-of-coronary-stenosis-with-independent-quantitative-coronary-angiography-findings-from-the-prospective-multicenter-imaging-study-for-evaluation-of-chest-pain-promise-trial
#8
Rohan Shah, Eric Yow, William Schuyler Jones, Louis P Kohl, Andrzej S Kosinski, Udo Hoffmann, Kerry L Lee, Christopher B Fordyce, Daniel B Mark, Alicia Lowe, Pamela S Douglas, Manesh R Patel
: The outcomes in patients by visual assessment and quantitative coronary angiography (QCA) for obstructive coronary artery disease (CAD) are not known. Our objectives were to compare visual and QCA estimates of obstructive CAD and to assess their relationship to outcomes in stable patients with symptoms of CAD. METHODS: The PROMISE trial randomized 10,003 patients with CAD symptoms to anatomical or functional testing. Site reports of invasive angiography detailing visual stenosis and independent, blinded QCA were performed for obstructive CAD (≥50% stenosis)...
October 26, 2016: American Heart Journal
https://www.readbyqxmd.com/read/27888764/clinical-characteristics-and-prognosis-of-acute-coronary-syndrome-in-young-women-and-men-a-systematic-review-and-meta-analysis-of-prospective-studies
#9
Qinghua Ma, Jinwen Wang, Jing Jin, Ming Gao, Fang Liu, Shanshan Zhou, Feng Tian, Jie Liu, Yuqi Liu, Yundai Chen
OBJECTIVES: The clinical characteristics and prognosis of young women (≤50years) with acute coronary syndrome (ACS) are still unclear. METHODS: A total of 5196 patients with ACS were enrolled from the cardiac center of Chinese PLA General Hospital and Anzhen Hospital. The clinical characteristics of these patients were analyzed. Then the PubMed, EMBASE, and Cochrane Central Register of Controlled Trials electronic databases were searched from January 2001 to July 2016...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27888478/examining-the-quality-of-medicines-at-kenyan-healthcare-facilities-a-validation-of-an-alternative-post-market-surveillance-model-that-uses-standardized-patients
#10
Francis Wafula, Amy Dolinger, Benjamin Daniels, Njeri Mwaura, Guadalupe Bedoya, Khama Rogo, Ana Goicoechea, Jishnu Das, Bernard Olayo
BACKGROUND: Promoting access to medicines requires concurrent efforts to strengthen quality assurance for sustained impact. Although problems of substandard and falsified medicines have been documented in low- and middle-income countries, reliable information on quality is rarely available. OBJECTIVE: The aim of this study was to validate an alternative post-market surveillance model to complement existing models. METHODS: The study used standardized patients or mystery clients (people recruited from the local community and trained to pose as real patients) to collect medicine samples after presenting a pre-specified condition...
November 25, 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27881850/relationship-between-asymptomatic-intra-cranial-lesions-and-brachial-ankle-pulse-wave-velocity-in-coronary-artery-disease-patients-without-stroke
#11
Noriaki Tabata, Daisuke Sueta, Takayoshi Yamashita, Daisuke Utsunomiya, Yuichiro Arima, Eiichiro Yamamoto, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Seiji Hokimoto
Little is known about the significance of asymptomatic intra-cranial lesions (ICL) identified by brain MRI in coronary artery disease (CAD) patients. Silent cerebral lesions are suggested to be associated with arterial stiffness in healthy subjects. We investigated whether subclinical ICL are associated with arterial stiffness and the prognosis in CAD patients without medical history of cerebrovascular diseases. We recruited CAD patients who required percutaneous coronary intervention (PCI), did not meet exclusion criteria, and agreed with MRI before PCI...
November 24, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27881527/clinical-factors-associated-with-initiation-of-and-persistence-with-adp-receptor-inhibiting-oral-antiplatelet-treatment-after-acute-coronary-syndrome-a-nationwide-cohort-study-from-finland
#12
Tuire Prami, Houssem Khanfir, Anna Deleskog, Pål Hasvold, Ville Kytö, Eeva Reissell, Juhani Airaksinen
OBJECTIVES: To study patient selection for and persistence with ADP receptor-inhibiting oral antiplatelet (OAP) treatment after acute coronary syndrome (ACS). DESIGN: Observational, retrospective, cohort study linking real-life patient-level register data. SETTING: Nationwide drug usage study using data of patients with ACS discharged from hospitals in Finland. PARTICIPANTS: The study population consisted of 54 416 patients (aged ≥18 years) following hospital admission for unstable angina pectoris or myocardial infarction during 2009-2013...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27879192/n-terminal-probrain-natriuretic-peptide-in-patients-with-acute-coronary-syndrome%C3%A2
#13
Qi Kang, Zheng Wan, Zhenwen Huang
OBJECTIVE: To observe the changes and evaluate the significance of serum N-terminal probrain natriuretic peptide (NT-proBNP) levels in patients with acute coronary syndrome and to discuss its clinical significance and relationship with the severity of disease. METHODS: Serum NT-proBNP levels were determined rapidly by using the triage BNP test for 98 consecutive patients with coronary heart disease (CAD) admitted to the hospital from March 2013 to December 2013; the correlation between the concentration of NT-proBNP and the degree of severity of the disease was analyzed...
November 23, 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27866136/biodegradable-polymer-based-argatroban-eluting-cobalt-chromium-stent-jf-04-for-treatment-of-native-coronary-lesions-final-results-of-the-first-in-man-study-and-lessons-learned
#14
Yoshihiro Morino, Tetsuya Tobaru, Satoshi Yasuda, Kazuaki Kataoka, Kengo Tanabe, Atsushi Hirohata, Ken Kozuma, Takeshi Kimura
AIMS: The aim of the study was to investigate the six-month angiographic and nine-month clinical follow-up outcomes in a first-in-man study using the biodegradable polymer-based cobalt-chromium argatroban-eluting stent (JF-04) for treatment of native coronary atherosclerotic lesions. METHODS AND RESULTS: A total of 31 patients with either stable or unstable angina, or silent myocardial ischaemia, exhibiting de novo coronary lesions were enrolled at seven Japanese sites...
November 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27865674/does-anemia-affect-the-predictive-ability-of-bleeding-risk-scores-in-patients-with-acute-coronary-syndromes
#15
Alberto Garay, Albert Ariza-Solé, Francesc Formiga, Victoria Lorente, José C Sánchez-Salado, Joel Salazar-Mendiguchía, Gerard Roura, Guillem Muntané, Oriol Alegre, Lara Fuentes, Joan A Gómez-Hospital, Angel Cequier
INTRODUCTION AND OBJECTIVE: Anemia is a common comorbidity in patients with acute coronary syndromes (ACS), and is associated with higher risk for both bleeding and ischemic complications. We aimed to assess the predictive ability of bleeding risk scores (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines [CRUSADE], Mehran and Acute Coronary Treatment and Intervention Outcomes Network [ACTION]) in ACS patients with anemia...
December 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27864249/positive-predictive-value-of-cardiovascular-diagnoses-in-the-danish-national-patient-registry-a-validation-study
#16
Jens Sundbøll, Kasper Adelborg, Troels Munch, Trine Frøslev, Henrik Toft Sørensen, Hans Erik Bøtker, Morten Schmidt
OBJECTIVE: The majority of cardiovascular diagnoses in the Danish National Patient Registry (DNPR) remain to be validated despite extensive use in epidemiological research. We therefore examined the positive predictive value (PPV) of cardiovascular diagnoses in the DNPR. DESIGN: Population-based validation study. SETTING: 1 university hospital and 2 regional hospitals in the Central Denmark Region, 2010-2012. PARTICIPANTS: For each cardiovascular diagnosis, up to 100 patients from participating hospitals were randomly sampled during the study period using the DNPR...
November 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27842619/congenital-coronary-artery-anomalies-in-adults-review-of-111-cases-from-a-single-centre-experience
#17
Yiğit Çanga, Tolga S Güvenç, Mehmet B Karataş, Ali N Çalık, Tolga Onuk, Veysel O Tanık, Barış Güngör, Osman Bolca
BACKGROUND: Coronary artery anomalies are a heterogeneous group of congenital disorders presenting with a wide spectrum of symptoms, ranging from vague chest pain to sudden cardiac death. Despite available data, there is no consensus about the classification, nomenclature, and outcomes of coronary anomalies in the normally connected heart. In this study, we aimed to investigate clinical and angiographic characteristics of coronary arterial anomalies, as well as the frequency of atherosclerotic involvement in anomalous coronaries, diagnosed at a tertiary referral centre...
November 15, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27831644/study-on-the-levels-of-uric-acid-and-high-sensitivity-c-reactive-protein-in-acs-patients-and-their-relationships-with-the-extent-of-the-coronary-artery-lesion
#18
Q-Q Ma, X-J Yang, N-Q Yang, L Liu, X-D Li, K Zhu, Q Fu, P Wei
OBJECTIVE: We evaluated uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) levels in different clinical types of acute coronary syndromes (ACS) and in relationship with the severity of coronary artery lesions. Furthermore, we explored its clinical significance. PATIENTS AND METHODS: From June 2013 to January 2015, we studied patients in their first onset of symptoms and hospitalization for coronary angiography. According to coronary angiography results, we divided patients into two groups: 93 patients with ACS and 30 patients with normal coronary arteries as the control group...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27829644/intra-plaque-hematoma-and-minor-intimal-disruption-detected-by-optical-frequency-domain-imaging-in-a-case-of-acute-coronary-syndrome
#19
Motoki Fukutomi, Nobuhiko Ogata, Masataka Nakano, Kazuomi Kario
A 39-year-old man exhibiting unstable angina was admitted to our hospital, and urgent coronary angiography revealed stenosis of the proximal left anterior descending coronary artery (LAD). A drug eluting stent was implanted at this site, and the patient was discharged uneventfully on the 3rd hospital day. Optical frequency-domain imaging (OFDI) was successful in detecting an intra-plaque hematoma, minor intimal disruption, and thrombus at the culprit lesion in this patient. These observations suggest that this hematoma might be the result of subsequent blood filling into the ruptured plaque through this minor intimal disruption...
November 9, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27821850/a-comparative-metabolomics-approach-reveals-early-biomarkers-for-metabolic-response-to-acute-myocardial-infarction
#20
Sara E Ali, Mohamed A Farag, Paul Holvoet, Rasha S Hanafi, Mohamed Z Gad
Discovery of novel biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Serum metabolite profiling of ST-elevation myocardial infarction (STEMI), unstable angina (UA) and healthy controls was performed using gas chromatography mass spectrometry (GC/MS), solid-phase microextraction coupled to gas chromatography mass spectrometry (SPME-GC/MS) and nuclear magnetic resonance ((1)H-NMR). Multivariate data analysis revealed a metabolic signature that could robustly discriminate STEMI patients from both healthy controls and UA patients...
November 8, 2016: Scientific Reports
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