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https://www.readbyqxmd.com/read/29468706/comparative-cardiovascular-safety-of-non-steroidal-anti-inflammatory-drugs-in-patients-with-hypertension-a-population-based-cohort-study
#1
Yaa-Hui Dong, Chia-Hsuin Chang, Li-Chiu Wu, Jing-Shiang Hwang, Sengwee Toh
AIMS: Prior studies have suggested that non-steroidal anti-inflammatory drugs (NSAIDs) may be associated with higher cardiovascular risks. Few were active-comparison studies that directly assessed potential differential cardiovascular risk between NSAID classes or across individual NSAIDs. We compared the risk of major cardiovascular events between cyclooxygenase-2 enzyme (COX-2) selective NSAIDs and nonselective NSAIDs in patients with hypertension. METHODS: We conducted a cohort study of patients with hypertension who initiated COX-2 selective NSAIDs or nonselective NSAIDs in a population-based Taiwanese database...
February 22, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29462281/linking-hospital-patient-records-for-suspected-or-established-acute-coronary-syndrome-in-a-complex-secondary-care-system-a-proof-of-concept-e-registry-in-nhs-scotland
#2
Iain Findlay, Tamsin Morris, Ruiqi Zhang, Colin McCowan, Sarah Shield, Brian Forbes, Alex McConnachie, Kenneth Mangion, Colin Berry
Aims: To implement secondary care electronic record linkage for patients hospitalised with suspected or known acute coronary syndrome (ACS) in a complex regional healthcare system and evaluate this e-Registry in terms of patterns of service delivery and 1-year outcomes. Methods and Results: Existing electronic hospital records were linked to create episodes of care using (1) a patient administration system, (2) invasive cardiovascular procedure referrals and (3) a catheter laboratory record...
February 16, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29456049/six-month-outcomes-after-high-risk-coronary-artery-bypass-graft-surgery-and-preoperative-intra-aortic-balloon-counterpulsation-use-an-inception-cohort-study
#3
Edward Litton, Frances Bass, Anthony Delaney, Graham Hillis, Silvana Marasco, Shay McGuinness, Paul S Myles, Christopher M Reid, Julian A Smith
OBJECTIVE: To inform the design of a pivotal randomized controlled trial of prophylactic intra-aortic balloon counterpulsation (IABC) in patients undergoing coronary artery bypass graft (CABG) at high risk of postoperative low cardiac output syndrome (LCOS). DESIGN: Inception cohort study. SETTING: A total of 13 established cardiac centers in Australia, Canada, New Zealand, and the United Kingdom. PARTICIPANTS: Adult patients were eligible for inclusion if they were listed for CABG surgery and had 2 or more LCOS risk factors (low ejection fraction, severe left main coronary artery disease, redo sternotomy, unstable angina)...
January 5, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29455771/angiographic-predictors-of-success-in-antegrade-approach-of-chronic-total-occlusion-interventions-in-a-south-indian-population-in-the-contemporary-era
#4
Gopakumar Ks, Mathew Iype, Sunitha Viswanathan, A George Koshy, Prabha Nini Gupta, K Sivaprasad, V V Radhakrishnan
Chronic Total Occlusion (CTO) intervention is a challenging area in interventional cardiology. Presently about 70% of CTO interventions are successful. MATERIALS AND METHODS: This was a single center prospective study of a cohort of all patients undergoing percutaneous coronary intervention (PCI) as elective or adhoc procedure for CTO from August 2014 to June 2015. Only antegrade CTO interventions were included. In all patients the following data were recorded. RESULTS: A total of 210 (8...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29453329/management-characteristics-and-outcomes-of-patients-with-acute-coronary-syndrome-in-sri-lanka
#5
Priyadarshani Galappatthy, Vipula R Bataduwaarachchi, Priyanga Ranasinghe, Gamini K S Galappatthy, Maheshi Wijayabandara, Dinuka S Warapitiya, Mythily Sivapathasundaram, Thilini Wickramarathna, Upul Senarath, Sathasivam Sridharan, Chandrika N Wijeyaratne, Ruvan Ekanayaka
BACKGROUND: Ischaemic heart disease is the leading cause of in-hospital mortality in Sri Lanka. Acute Coronary Syndrome Sri Lanka Audit Project (ACSSLAP) is the first national clinical-audit project that evaluated patient characteristics, clinical outcomes and care provided by state-sector hospitals. METHODS: ACSSLAP prospectively evaluated acute care, in-hospital care and discharge plans provided by all state-sector hospitals managing patients with ACS. Data were collected from 30 consecutive patients from each hospital during 2-4 weeks window...
February 16, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29452348/non-invasive-screening-for-coronary-artery-disease-in-asymptomatic-diabetic-patients-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#6
Olivier F Clerc, Tobias A Fuchs, Julia Stehli, Dominik C Benz, Christoph Gräni, Michael Messerli, Andreas A Giannopoulos, Ronny R Buechel, Thomas F Lüscher, Aju P Pazhenkottil, Philipp A Kaufmann, Oliver Gaemperli
It is unclear whether non-invasive screening of asymptomatic diabetic patients for coronary artery disease (CAD) may improve cardiac outcomes. Thus, we performed a systematic literature review and meta-analysis of randomised controlled trials (RCT's) on this topic. We searched appropriate RCT's in five online databases (PubMed/MEDLINE, Cochrane Library, Embase, Scopus, and Web of Science) from January 2000 to November 2017 and in 41 recent reviews. Two investigators independently extracted and assessed study data using standardised forms...
February 14, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29446829/injection-testosterone-and-adverse-cardiovascular-events-a-case-crossover-analysis
#7
J Bradley Layton, Dongmei Li, Christoph R Meier, Julie L Sharpless, Til Stürmer, M Alan Brookhart
CONTEXT: Exogenous testosterone administration may affect blood clotting, polycythemia, and may increase atherosclerosis, though any association with cardiovascular events is unclear. While the literature is inconclusive, some studies have suggested testosterone use may increase short-term risk of cardiovascular events and stroke, and injection testosterone may convey higher risks than other dosage forms. OBJECTIVE: We sought to evaluate the short-term cardiovascular risk of receiving injection testosterone...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29445056/decreased-serum-relaxin-2-is-correlated-with-impaired-islet-%C3%AE-cell-function-in-patients-with-unstable-angina-and-abnormal-glucose-metabolism
#8
Xiangyu Gao, Hongwei Li, Ping Wang, Hui Chen
Circulating relaxin (RLX) is altered in patients with diabetes mellitus (DM) or cardiovascular diseases. This study was designed to evaluate the changes of RLX in patients with unstable angina (UA) complicated with various categories of abnormal glucose metabolism.Patients who confirmed UA by angiographic and clinical standard were grouped according to the glucose metabolism status with oral glucose tolerance test (OGTT) and medical history categorized as normal, prediabetes, newly diagnosed type 2 DM (T2DM), and previously diagnosed T2DM...
February 14, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29442524/exacerbations-of-chronic-obstructive-pulmonary-disease-and-cardiac-events-a-cohort-analysis
#9
Ken M Kunisaki, Mark T Dransfield, Julie A Anderson, Robert D Brook, Peter M A Calverley, Bartolome R Celli, Courtney Crim, Benjamin F Hartley, Fernando J Martinez, David E Newby, Alexa A Pragman, Jørgen Vestbo, Julie C Yates, Dennis E Niewoehner
RATIONALE: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are common, associated with acute inflammation, and may increase subsequent cardiovascular disease (CVD) risk. OBJECTIVE: Determine if AECOPD events are associated with increased risk of subsequent CVD. METHODS: A secondary cohort analysis of the Study to Understand Mortality and MorbidITy (SUMMIT) trial, a convenience sample of current/former smokers with moderate COPD from 1,368 centers in 43 countries...
February 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29434722/analysis-of-long-non-coding-rna-expression-profiles-identifies-functional-lncrnas-associated-with-the-progression-of-acute-coronary-syndromes
#10
Yingjie Lu, Xiangwei Meng, Lifeng Wang, Xiaoyun Wang
It has been demonstrated that long non-coding RNAs (lncRNAs) are important in the gene regulatory network and their dysregulated expression has been implicated in cardiovascular disease. However, little is known regarding lncRNA expression patterns and their function in the progression of acute coronary syndromes (ACSs). In the present study, the expression profiles of lncRNAs from 52 patients with ACS were analyzed by re-annotating existing microarray data. The lncRNA expression profiles in the two distinct clinical entities of ACS, myocardial infarction (MI) and unstable angina (UA), were examined...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434124/the-usefulness-and-limitations-of-point-of-care-cardiac-troponin-measurement-in-the-emergency-department
#11
Kenichiro Suzuki, Kimiaki Komukai, Kotaro Nakata, Renshi Kan, Yuhei Oi, Eri Muto, Yusuke Kashiwagi, Mitsutoshi Tominaga, Satoru Miyanaga, Tetsuya Ishikawa, Kenji Okuno, Masahiko Uzura, Michihiro Yoshimura
Objective This study was carried out to examine the usefulness of point-of-care (POC) cardiac troponin in diagnosing acute coronary syndrome (ACS) and to understand the limitations of a POC cardiac troponin I/T-based diagnoses. Methods Patients whose cardiac troponin levels were measured in the emergency department using a POC system (AQT System; Radiometer, Tokyo, Japan) between January and December 2016 were retrospectively examined (N=1449). Patients who were < 20 years of age or who were admitted with cardiopulmonary arrest were excluded...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432377/two-year-follow-up-of-patients-with-unstable-angina-non-st-segment-elevation-myocardial-infarction-undergoing-early-invasive-strategy-predictors-of-normal-or-near-normal-coronary-angiography-and-mortality
#12
Yaser Jenab, Ebrahim Kassaian, Hamid Reza Pourhosseini, Mojtaba Salarifar, Arash Jalali, Azita Hajhossein Talasaz
BACKGROUND: Predictors of normal or near-normal coronary angiography (NONCAG) in patients with unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI) and their importance regarding the prognosis are not understood. Accordingly, we determined these predictors as well as mortality risk factors at 2-year follow-up of UA/NSTEMI patients managed by the early invasive strategy. METHODS: We prospectively studied consecutive patients with UA/NSTEMI managed with the early invasive strategy at Tehran Heart Center, in 1-year period...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29428559/elevated-il-27-in-patients-with-acute-coronary-syndrome-is-associated-with-adverse-ventricular-remodeling-and-increased-risk-of-recurrent-myocardial-infarction-and-cardiovascular-death
#13
Helena Grufman, Troels Yndigegn, Isabel Gonçalves, Jan Nilsson, Alexandru Schiopu
BACKGROUND AND AIMS: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. METHODS: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA). A subgroup of 107 patients donated blood samples 6 weeks after the index event, and underwent a follow-up echocardiographical examination at 1 year...
February 7, 2018: Cytokine
https://www.readbyqxmd.com/read/29426672/clinical-scales-tools-for-the-diagnosis-of-unstable-angina
#14
EDITORIAL
A Alquézar-Arbé, B Lopez Barbeito
No abstract text is available yet for this article.
February 6, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29415754/guanxinning-tablet-for-patients-who-switch-from-dual-antiplatelet-therapy-to-aspirin-alone-after-percutaneous-coronary-intervention-study-protocol-for%C3%A2-a-cluster-randomized-controlled-trial
#15
Jingen Li, Jianqing Ju, Zhuo Chen, Jing Liu, Fang Lu, Rui Gao, Hao Xu
BACKGROUND: One-year dual antiplatelet therapy (DAPT), generally aspirin in combination with a P2Y12 receptor inhibitor, has been a standard treatment for patients undergoing percutaneous coronary intervention (PCI). Prolonged DAPT has proven itself effective in further reducing cardiovascular events, yet with increased risk of bleeding. Thus, it is of great necessity to find an alternative drug that is as effective but safer and more economic than the P2Y12 inhibitors after termination of one-year DAPT...
February 7, 2018: Trials
https://www.readbyqxmd.com/read/29411245/single-coronary-artery-anomaly-a-case-report-and-review-of-literature
#16
Ayman Elbadawi, Basarat Baig, Islam Y Elgendy, Erfan Alotaki, Ahmed H Mohamed, Kirolos Barssoum, David Fries, Muhammad Khan, Rami N Khouzam
INTRODUCTION: Single coronary artery is a rare anomaly, which is usually associated with other cardiac congenital abnormalities. CASE REPORT: A 56-year-old female presented with unstable angina. The patient reported complaints of typical chest pain on exertion few months prior to presentation, which progressed to become at rest. The pain was associated palpitations and dizziness. Past medical history was significant for hypertension and hyperlipidemia. Vital signs were stable...
February 6, 2018: Cardiology and Therapy
https://www.readbyqxmd.com/read/29406944/coronary-artery-disease-diagnosis-and-management
#17
REVIEW
Stephen D Cagle, Noah Cooperstein
This review focuses on the outpatient assessment and management of coronary artery disease based on current guidelines and recommendations. The management of acute coronary syndrome and unstable angina is not included. Pharmacologic and nonpharmacotherapy options, including lifestyle modifications, are discussed with evidence to support recommendations and suggested management.
March 2018: Primary Care
https://www.readbyqxmd.com/read/29400582/prognostic-value-of-tissue-doppler-e-e-ratio-in-hypertension-patients-with-preserved-left-ventricular-ejection-fraction
#18
Dan Zhou, Yuqing Huang, Ming Fu, Anping Cai, Songtao Tang, Yingqing Feng
OBJECTIVES: This study aims to investigate the association of tissue Doppler E/e' with cardiac events in hypertension patients, independent of and incremental to clinical and left ventricular geometric patterns. METHODS: We retrospectively enrolled 222 asymptomatic nonischemic patients with hypertension who had echocardiogram in 2012 to evaluate tissue Doppler E/e'. Patients were followed up for cardiac events (cardiac events were defined as myocardial infarction, coronary revascularization procedures, new-onset angina (stable or unstable), heart failure)...
February 5, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29399084/blood-rheology-of-angina-pectoris-patients-with-myocardial-injury-after-ischemia-reperfusion-and-its-effect-on-thromboxane-b2-levels
#19
Wenlong Wang, Xiaohui Huang, Yiyong Sun, Jinying Zhang
This study investigated the changes in the blood rheology of patients with angina pectoris and ischemia reperfusion injury and their effect on thromboxane B2 (TXB2) levels to examine their relationship. Forty patients with unstable angina pectoris who underwent elective percutaneous coronary intervention (PCI) were selected for the unstable angina group (UA group) and forty patients deemed free of coronary heart disease by coronary angiography were selected for the control group. Venous blood samples were drawn from all participants; patients in the UA group had blood drawn 1 day before and 1 day after the PCI procedure...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29398161/analgesic-use-and-risk-for-acute-coronary-events-in-patients-with-osteoarthritis-a-population-based-nested-case-control-study
#20
Caridad Pontes, Josep Ramon Marsal, Josep Maria Elorza, Maria Aragón, Daniel Prieto-Alhambra, Rosa Morros
PURPOSE: Recent controversies on the safety profiles of opioids and paracetamol (acetaminophen) have led to changes in clinical guidance on osteoarthritis (OA) management. We studied the existing association between the use of different OA drug therapies and the risk for acute coronary events. METHODS: A cohort of patients with clinically diagnosed OA (according to ICD-10 codes) was identified in the SIDIAP database. Within the cohort, cases with incident acute coronary events (acute myocardial infarction or unstable angina) between 2008 and 2012 were identified using ICD-10 codes and data from hospital admission...
February 2, 2018: Clinical Therapeutics
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