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https://www.readbyqxmd.com/read/29169184/her2-expression-patterns-in-paired-primary-and-metastatic-endometrial-cancer-lesions
#1
Mari Kyllesø Halle, Ingvild Løberg Tangen, Hege Fredriksen Berg, Erling Andre Hoivik, Karen K Mauland, Kanthida Kusonmano, Anna Berg, Antoni Hurtado, Karl Henning Kalland, Anne M Øyan, Ingunn Stefansson, Olav K Vintermyr, Henrica M Werner, Ingfrid S Haldorsen, Jone Trovik, Helga B Salvesen, Camilla Krakstad
BACKGROUND: Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) receptor in breast and gastric cancers, the potential of HER2 as a therapeutic target in other cancers has been less studied, including endometrial cancer. We investigated expression levels of HER2 (ERBB2) in a large cohort of endometrial cancer lesions, also including complex atypical hyperplasia and metastatic lesions. METHODS: 67 precursor lesions, 790 primary endometrial cancers and 383 metastatic lesions were investigated for HER2 expression in relation to clinicopathologic features and outcome...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29168762/dual-roles-of-fer-kinase-are-required-for-proper-hematopoiesis-and-vascular-endothelium-organization-during-zebrafish-development
#2
Emily M Dunn, Elizabeth J Billquist, Amy L VanderStoep, Phillip G Bax, Laura M Westrate, Lisa K McLellan, Shelby C Peterson, Jeffrey P MacKeigan, Aaron P Putzke
Fer kinase, a protein involved in the regulation of cell-cell adhesion and proliferation, has been shown to be required during invertebrate development and has been implicated in leukemia, gastric cancer, and liver cancer. However, in vivo roles for Fer during vertebrate development have remained elusive. In this study, we bridge the gap between the invertebrate and vertebrate realms by showing that Fer kinase is required during zebrafish embryogenesis for normal hematopoiesis and vascular organization with distinct kinase dependent and independent functions...
November 23, 2017: Biology
https://www.readbyqxmd.com/read/29168576/clinical-value-of-peripheral-blood-microrna-detection-in-evaluation-of-sox-regimen-as-neoadjuvant-chemotherapy-for-gastric-cancer
#3
Bibo Tan, Yong Li, Yan Di, Liqiao Fan, Qun Zhao, Qingwei Liu, Dong Wang, Nan Jia
BACKGROUND: Neoadjuvant chemotherapy has been widely applied in treating advanced gastric cancer (GC). However, little research has been conducted on evaluating the effect of neoadjuvant chemotherapy. Purpose of this study was to evaluate the effect of SOX regimen as neoadjuvant chemotherapy by detecting some microRNAs. METHODS: Total 120 GC patients who had received neoadjuvant chemotherapy (SOX regimen) were recruited with 100 healthy participants as control contemporarily...
November 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29168471/complete-response-of-metastatic-gastric-cancer-to-chemoimmunotherapy
#4
Kenji Ina, Ryuichi Furuta
No abstract text is available yet for this article.
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168410/response-to-the-letter-to-the-editor-reliability-of-rapid-urease-test-for-screening-gastric-cancer-in-high-risk-populations
#5
Jun-Hyung Cho
No abstract text is available yet for this article.
November 23, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29168284/association-of-preoperative-serum-total-cholesterol-level-with-postoperative-pain-outcomes-after-laparoscopic-surgery-for-gastric-cancer
#6
Tak Kyu Oh, Hyung-Ho Kim, Do Joong Park, Sang-Hoon Ahn, Sang-Hwan Do, Jung-Won Hwang, Jin Hee Kim, Ah-Young Oh, Young-Tae Jeon, In-Ae Song
BACKGROUND: Opioid usage is reportedly increased in patients with advanced cancer and low total cholesterol (TC). The aim of this study was to determine the effects of preoperative serum TC levels on postoperative opioid usage in patients undergoing laparoscopic gastric cancer surgery. METHODS: We retrospectively analyzed the medical records of patients with gastric cancer who underwent laparoscopic gastrectomy at our institution between January 1, 2011 and July 31, 2017...
November 23, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29168120/the-8th-edition-of-the-american-joint-committee-on-cancer-tumor-node-metastasis-staging-system-for-gastric-cancer-is-superior-to-the-7th-edition-results-from-a-chinese-mono-institutional-study-of-1663-patients
#7
Xin Ji, Zhao-De Bu, Yan Yan, Zi-Yu Li, Ai-Wen Wu, Lian-Hai Zhang, Ji Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Shuang-Xi Li, Fei Shan, Zi-Yu Jia, Jia-Fu Ji
BACKGROUND: We investigated the superiority of the 8th edition of the tumor-node-metastasis (TNM) system for patients in China with gastric cancer. METHODS: The survival outcomes of 1663 patients with gastric cancer undergoing radical resection were analyzed. RESULTS: In the 8th edition system, homogeneous 5-year survival rates among different pathological TNM (pTNM) categories belonging to the same stage were observed. However, in the 7th edition system, the differences of 5-year survival rate among pTNM categories belonging to the same stage were observed in stages IIB (P = 0...
November 22, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29168119/clinical-and-biological-significance-of-a-%C3%A2-73a%C3%A2-%C3%A2-c-variation-in-the-cdh1-promoter-of-patients-with-sporadic-gastric-carcinoma
#8
Baozhen Zhang, Jing Zhou, Zhaojun Liu, Liankun Gu, Jiafu Ji, Woo Ho Kim, Dajun Deng
BACKGROUND: CDH1 germline mutations lead to hereditary diffuse gastric carcinomas. However, it is unclear whether genetic variations in the CDH1 promoter affect the progression of sporadic gastric carcinomas (SGCs). METHODS: SGC patients in two independent cohorts with follow-up data were enrolled. The CDH1 genotypes, including the - 73A > C polymorphism (rs28372783), were determined by PCR sequencing. The CDH1 promoter activity was determined using reporter assays...
November 22, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29168107/predictive-factors-of-trastuzumab-based-chemotherapy-in-her2-positive-advanced-gastric-cancer-a-single-center-prospective-observational-study
#9
Q Li, H Li, H Jiang, Y Feng, Y Cui, Y Wang, Y Ji, Y Yu, W Li, C Xu, S Yu, R Zhuang, T Liu
PURPOSE: Trastuzumab plus chemotherapy is an effective therapy in HER2 positive advanced gastric cancer (AGC). However, the clinicopathologic factors that predict the outcome of routine trastuzumab therapy remain unclear. METHODS: The outcome and safety profile of trastuzumab therapy in untreated HER2 positive AGC was evaluated in this prospective observational study. Clinical and pathological data including demographics, treatment profiles, expression level of HER2 were analyzed to identify predictive factors of trastuzumab-based first-line therapy for their progression-free survival (PFS)...
November 22, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29167832/assessment-of-nutritional-status-in-laparoscopic-gastrectomy-for-gastric-cancer
#10
REVIEW
Young-Gil Son, In Gyu Kwon, Seung Wan Ryu
Malnutrition is very common in gastric cancer patients and can be detected in up to 85% of patients with gastric cancer. Malnutrition is associated with increased morbidity and mortality, prolonged hospital stay, poor treatment tolerance, and lower survival rate. Malnutrition also has an impact on quality of life. The early detection of nutritional risk with appropriate nutritional care can significantly reduce patient's postoperative morbidity and mortality. Because there is no gold standard tool, appropriate tools should be selected and applied depending on one's institutional conditions...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29167831/laparoscopic-distal-gastrectomy-with-d2-lymphadenectomy-followed-by-intracorporeal-gastroduodenostomy-for-advanced-gastric-cancer-technical-guide-and-tips
#11
REVIEW
Sang-Woong Lee, Masaru Kawai, Keitaro Tashiro, George Bouras, Satoshi Kawashima, Ryo Tanaka, Eiji Nomura, Kazuhisa Uchiyama
In 1994, Kitano and colleagues first reported laparoscopy-assisted Billroth I gastrectomy. Since then, laparoscopic gastrectomy (LG) has been associated with earlier patient recovery compared with open surgery, and has gained increasing international acceptance. Japan Society of Endoscopic Surgery biennial surveys confirm the increasing use of laparoscopic procedures for treatment of gastric cancer in Japan. Its thirteenth national survey indicates that of 31,264 patients treated at Japanese institutions in 2015, approximately 9,500 (30...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29167690/synchronous-gists-associated-with-multiple-sporadic-tumors-a-case-report
#12
Danila Comandini, Azzurra Damiani, Alessandro Pastorino
Gastrointestinal stromal tumors (GISTs) are rare neoplasms, but they also represent the most common mesenchymal tumors of the gastrointestinal tract originating from the cell of Cajal. GIST incidence ranges around 1% of all gastrointestinal malignancies. Approximately 5% of all GISTs have a hereditary etiology. The remaining 95% of GISTs are considered sporadic events, with up to 75% of cases driven by a constitutional activation of the c-KIT proto-oncogene. GISTs are generally solitary lesions. Nonetheless, multiple sporadic GISTs can occur and present as synchronous or metachronous tumors, usually associated with familial GIST...
2017: Drugs in Context
https://www.readbyqxmd.com/read/29166909/multiscale-positive-feedbacks-contribute-to-unidirectional-gastric-disease-progression-induced-by-helicobacter-pylori-infection
#13
Richard Ballweg, Frederick Schozer, Kelsey Elliott, Alexander Kuhn, Logan Spotts, Eitaro Aihara, Tongli Zhang
BACKGROUND: Helicobacter Pylori (HP) is the most common risk factor for gastric cancer. Nearly half the world's population is infected with HP, but only a small percentage of those develop significant pathology. The bacteria itself does not directly cause cancer; rather it promotes an environment that is conducive to tumor formation. Upon infection, HP induces transcriptional changes in the host, leading to enhanced proliferation and host immune response. In addition, HP causes direct damage to gastric epithelial cells...
November 22, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29166882/polymorphisms-in-adh1b-and-aldh2-genes-associated-with-the-increased-risk-of-gastric-cancer-in-west-bengal-india
#14
Sudakshina Ghosh, Biswabandhu Bankura, Soumee Ghosh, Makhan Lal Saha, Arup Kumar Pattanayak, Souvik Ghatak, Manalee Guha, Senthil Kumar Nachimuthu, Chinmoy Kumar Panda, Suvendu Maji, Subrata Chakraborty, Biswanath Maity, Madhusudan Das
BACKGROUND: Gastric cancer (GC) is one of the most frequently diagnosed digestive tract cancers and carries a high risk of mortality. Acetaldehyde (AA), a carcinogenic intermediate of ethanol metabolism contributes to the risk of GC. The accumulation of AA largely depends on the activity of the major metabolic enzymes, alcohol dehydrogenase and aldehyde dehydrogenase encoded by the ADH (ADH1 gene cluster: ADH1A, ADH1B and ADH1C) and ALDH2 genes, respectively. This study aimed to evaluate the association between genetic variants in these genes and GC risk in West Bengal, India...
November 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29166433/hypoglycemia-caused-by-co-secretion-of-insulin-from-lung-tumor-and-cardia-cancer-first-case-report
#15
Yaning Chen, Yi Kang, Liu Hong, Hebin Yao
CONTEXT: Non-islet-cell-tumor-induced hypoglycemia (NICTH) is caused on rare occasions by secretion of insulin from tumor cells that are reported to have a single tissue origin. CASE REPORT: A 67-year-old male patient had cardia adenocarcinoma and concomitant lung adenocarcinoma with extensive metastases and repeated episodes of intractable hypoglycemia. Immunohistochemical staining for insulin showed that lung adenocarcinoma stained positive and gastric cardia adenocarcinoma stained weakly positive...
November 17, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29165440/dynamic-characterization-of-drug-resistance-and-heterogeneity-of-the-gastric-cancer-cell-bgc823-using-single-cell-raman-spectroscopy
#16
Yong Zhang, Ludi Jin, Jingjing Xu, Yuezhou Yu, Lin Shen, Jing Gao, Anpei Ye
Drug resistance and heterogeneous characteristics of human gastric carcinoma cells (BGC823) under the treatment of paclitaxel (PTX) were investigated using single-cell Raman spectroscopy (RS). RS of normal and drug-resistant BGC823 cells (DR-BGC823) were collected and analyzed using arithmetic, statistic and individual spectrum analysis. The dynamic effects of paclitaxel (PTX) in normal and DR-BGC823 cells were evaluated dynamically. The RS intensity changed with PTX over time and produced distinct different results for the two types of cells...
November 22, 2017: Analyst
https://www.readbyqxmd.com/read/29164575/long-non-coding-rna-xloc_010235-correlates-with-poor-prognosis-and-promotes-tumorigenesis-of-hepatocellular-carcinoma
#17
F Yang, Y Jiang, L-Z Lv
OBJECTIVE: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Long non-coding RNAs (lncRNAs) are novel proposed non-coding RNAs, and play critical roles in tumorigenesis. However, the clinical significance, biological role and molecular mechanism of ncRNAs in HCC still remain largely elusive. The aim of this study was to uncover the clinical value and biological role of XLOC_010235 (XLOC), which has been demonstrated as an oncogene in gastric cancer, in HCC...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164360/risk-of-osteoporosis-after-gastrectomy-in-long-term-gastric-cancer-survivors
#18
Seung Hyun Yoo, Jung Ah Lee, Seo Young Kang, Young Sik Kim, Sung Sunwoo, Beom Soo Kim, Jeong-Hwan Yook
INTRODUCTION: Although early detection and successful gastrectomy have improved the survival of patients with gastric cancer, long-term health problems remain troubling. We evaluated the prevalence of osteoporosis and its risk factors in long-term survivors of gastric cancer after gastrectomy. METHODS: We reviewed the medical records of a tertiary hospital between 2007 and 2014 to identify survivors of gastric cancer who had visited our center at around 5 years after gastrectomy...
November 21, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29164283/gastric-cancer-metastatic-to-neck-lipoma-a-case-report-with-imaging-consideration
#19
Shuko Nomura, Noriko Kurihara, Tomohiko Ishikawa, Masaru Tateda, Junko Sakurada
A 71-year-old man visited our hospital for examination of a soft neck mass. Computed tomography and magnetic resonance imaging scans showed a well-circumscribed large lipomatous tumor with multiple nodules inside. Atypical lipomatous tumor or lipoma involving the lymph nodes was considered. Pathological examination of the surgical specimen suggested typical lipoma including multiple metastatic foci from gastric cancer. Subsequent endoscopy revealed a gastric tumor, which was histologically proven to be signet-ring cell carcinoma...
November 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29164159/gastric-pouch-mixed-adenoneuroendocrine-carcinoma-with-a-mixed-adenocarcinoma-component-after-roux-en-y-gastric-bypass
#20
Ricardo G Pastorello, Mariana Petaccia de Macedo, Wilson Luiz da Costa Junior, Maria Dirlei F S Begnami
The Roux-en-Y gastric bypass is one of the most common procedures currently performed for surgical treatment of patients with severe obesity. Gastric cancer after bariatric surgery is not common, with most of them arising in the excluded stomach. Gastric mixed adenoneuroendocrine carcinomas are a rare type of stomach malignancy, composed of both adenocarcinoma and neuroendocrine tumor-cell components, with the latter comprising at least 30% of the whole neoplasm. In this article, we report a unique case of a mixed adenoneuroendocrine carcinoma with a mixed adenocarcinoma (tubular and poorly cohesive) component arising in the gastric pouch of a patient who underwent previous Roux-en-Y gastric bypass for glycemic control...
October 2017: Journal of Investigative Medicine High Impact Case Reports
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