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https://www.readbyqxmd.com/read/27862078/current-controversies-in-prenatal-diagnosis-1-in-utero-therapy-for-spina-bifida-is-ready-for-endoscopic-repair
#1
Michael Belfort, Jan Deprest, Kurt Hecher
No abstract text is available yet for this article.
November 18, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27783043/progressive-vascular-functional-and-structural-damage-in-a-bronchopulmonary-dysplasia-model-in-preterm-rabbits-exposed-to-hyperoxia
#2
Julio Jiménez, Jute Richter, Taro Nagatomo, Thomas Salaets, Rozenn Quarck, Allard Wagennar, Hongmei Wang, Jeroen Vanoirbeek, Jan Deprest, Jaan Toelen
Bronchopulmonary dysplasia (BPD) is caused by preterm neonatal lung injury and results in oxygen dependency and pulmonary hypertension. Current clinical management fails to reduce the incidence of BPD, which calls for novel therapies. Fetal rabbits have a lung development that mimics humans and can be used as a translational model to test novel treatment options. In preterm rabbits, exposure to hyperoxia leads to parenchymal changes, yet vascular damage has not been studied in this model. In this study we document the early functional and structural changes of the lung vasculature in preterm rabbits that are induced by hyperoxia after birth...
October 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27644443/abstracts-of-the-26th-world-congress-on-ultrasound-in-obstetrics-and-gynecology-rome-italy-24-28-september-2016
#3
M Yamamoto, V Dezerega, J Jimenez, J Astudillo, J Deprest
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27568096/connexin-43-is-overexpressed-in-human-fetal-membrane-defects-after-fetoscopic-surgery
#4
David W Barrett, Anna L David, Christopher Thrasivoulou, Alvaro Mata, David L Becker, Alex C Engels, Jan A Deprest, Tina T Chowdhury
OBJECTIVE: We examined whether surgically induced membrane defects elevate connexin 43 (Cx43) expression in the wound edge of the amniotic membrane (AM) and drives structural changes in collagen that affects healing after fetoscopic surgery. METHOD: Cell morphology and collagen microstructure was investigated by scanning electron microscopy and second harmonic generation in fetal membranes taken from women who underwent fetal surgery. Immunofluoresence and real-time quantitative polymerase chain reaction was used to examine Cx43 expression in control and wound edge AM...
October 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27567969/a-novel-translational-model-for-fetoscopic-intratracheal-delivery-of-nanoparticles-in-piglets
#5
Marianne S Carlon, Alexander C Engels, Barbara Bosch, Luc Joyeux, Marina G M C Mori da Cunha, Dragana Vidović, Zeger Debyser, Kris De Boeck, Arne Neyrinck, Jan A Deprest
OBJECTIVES: The aim of this study was to assess the feasibility of fetal tracheal injection in the late-gestational pig to target the airways. METHODS: Following laparotomy and hysterotomy, fetoscopy was performed in pregnant sows to access the fetal trachea. Two volumes of fluospheres were injected (1 and 3 mL). Fluosphere distribution to the different lung lobes was investigated by microscopy. Possible fetal airway injury, caused by the surgical procedure or intratracheal injection, was investigated...
October 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27567616/proton-pump-inhibitor-omeprazole-attenuates-hyperoxia-induced-lung-injury
#6
Jute Richter, Julio Jimenez, Taro Nagatomo, Jaan Toelen, Paul Brady, Thomas Salaets, Flore Lesage, Jeroen Vanoirbeek, Jan Deprest
BACKGROUND: The administration of supplemental oxygen to treat ventilatory insufficiency may lead to the formation of reactive oxygen species and subsequent tissue damage. Cytochrome P4501A1 (CYP1A1) can modulate hyperoxic lung injury by a currently unknown mechanism. Our objective was to evaluate the effect of administration of omeprazole on the induction of CYP1A1 and its influence on hyperoxic lung injury in an established preterm rabbit model. METHODS: Omeprazole was administered either (1) directly to the fetus, (2) to the mother or (3) after birth to the pups in different doses (2-10 or 20 mg/kg)...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27548820/vascular-endothelial-growth-factor-up-regulation-in-human-amniotic-fluid-stem-cell-enhances-nephroprotection-after-ischemia-reperfusion-injury-in-the-rat
#7
Marina Gabriela Monteiro Carvalho Mori da Cunha, Silvia Zia, Diego Vilibaldo Beckmann, Marianne Sylvia Carlon, Fanny Oliveira Arcolino, Maarten Albersen, Ney Luis Pippi, Dominguita Lühers Graça, Conny Gysemans, Peter Carmeliet, Elena Levtchenko, Jan Deprest, Jaan Toelen
OBJECTIVE: To evaluate if the up-regulation of vascular endothelial growth factor strengthens the protective effect of amniotic fluid stem cells in a renal ischemia-reperfusion injury model. DESIGN: Randomized animal study. SETTINGS: University research laboratory. SUBJECTS: A total of 40 males 12-week-old Wistar rats were subjected to ischemia-reperfusion and assigned to four groups: amniotic fluid stem cells, vascular endothelial growth factor-amniotic fluid stem cells in two different doses, and vehicle...
August 19, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27533315/esophageal-atresia-future-directions-for-research-on-the-digestive-tract
#8
Maissa Rayyan, Nathalie Rommel, Jan Tack, Jan Deprest, Karel Allegaert
Esophageal atresia (EA) is a congenital malformation defined by the discontinuity of the esophagus occurring in 2.4 in 10,000 births. As survival rates are high, the significant medical morbidity became more relevant. Short-term and long-term morbidities involve the respiratory and gastrointestinal system in the majority of the patients. The impact of this morbidity seems large enough to inspire researchers to develop experimental animal models that may help understanding the pathogenesis and pathophysiology...
August 17, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27478427/gynaecological-endoscopic-surgical-education-and-assessment-a-diploma-programme-in-gynaecological-endoscopic-surgery
#9
Rudi Campo, Arnaud Wattiez, Vasilis Tanos, Attilio Di Spiezio Sardo, Grigoris Grimbizis, Diethelm Wallwiener, Sara Brucker, Marco Puga, Roger Molinas, Peter O'Donovan, Jan Deprest, Yves Van Belle, Ann Lissens, Anja Herrmann, Mahmood Tahir, Chiara Benedetto, Igno Siebert, Benoit Rabischong, Rudy Leon De Wilde
In recent years, training and education in endoscopic surgery has been critically reviewed. Clinicians, both surgeons as gynaecologist who perform endoscopic surgery without proper training of the specific psychomotor skills, are at higher risk to increased patient morbidity and mortality. Although the apprentice-tutor model has long been a successful approach for training of surgeons, recently, clinicians have recognised that endoscopic surgery requires an important training phase outside the operating theatre...
2016: Gynecological Surgery
https://www.readbyqxmd.com/read/27381265/the-2015-malcolm-ferguson-smith-young-investigator-award
#10
EDITORIAL
Alessandro Ghidini, Diana W Bianchi, Brynn Levy, Jan Deprest, Tim van Mieghem, Lyn S Chitty, Amanda McLean-Inglis
No abstract text is available yet for this article.
July 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27378767/fertility-pregnancy-and-gynecological-outcomes-after-fetoscopic-surgery-for-congenital-diaphragmatic-hernia
#11
C Gregoir, A C Engels, O Gomez, P DeKoninck, L Lewi, E Gratacos, J A Deprest
STUDY QUESTION: What is the impact of fetoscopic surgery for isolated Congenital Diaphragmatic Hernia (CDH) on future reproductive and gynecological outcomes? SUMMARY ANSWER: We did not observe an increase of obstetric or gynecological problems after fetoscopic surgery nor was there an increased risk for subsequent infertility. WHAT IS KNOWN ALREADY: The reproductive and gynecological outcomes of patients undergoing open maternal-fetal surgery are known...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27312047/lung-size-and-liver-herniation-predict-the-need-for-extra-corporeal-membrane-oxygenation-but-not-pulmonary-hypertension-in-isolated-congenital-diaphragmatic-hernia-a-systematic-review-and-meta-analysis
#12
Francesca Maria Russo, Mary Patrice Eastwood, Richard Keijzer, Jamila Al-Maary, Jaan Toelen, Tim Van Mieghem, Jan A Deprest
OBJECTIVES: To identify antenatal predictors of persistent pulmonary hypertension (PPH) and need for extracorporeal membrane oxygenation (ECMO) in fetuses with congenital diaphragmatic hernia (CDH). MATERIAL AND METHODS: We performed a systematic literature review of antenatal diagnostic tests in fetuses with isolated CDH. The target conditions were PPH within 28 days of life and the need for ECMO. Quality of studies was assessed with the QUADAS-2 tool. Meta-analysis was performed when at least three studies reported on the same test...
June 17, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27301606/airway-tissue-engineering-for-congenital-laryngotracheal-disease
#13
Elizabeth Maughan, Flore Lesage, Colin R Butler, Robert E Hynds, Richard Hewitt, Sam M Janes, Jan A Deprest, Paolo De Coppi
Regenerative medicine offers hope of a sustainable solution for severe airway disease by the creation of functional, immunocompatible organ replacements. When considering fetuses and newborns, there is a specific spectrum of airway pathologies that could benefit from cell therapy and tissue engineering applications. While hypoplastic lungs associated with congenital diaphragmatic hernia (CDH) could benefit from cellular based treatments aimed at ameliorating lung function, patients with upper airway obstruction could take advantage from a de novo tissue engineering approach...
June 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27226787/laparoscopic-versus-robotic-assisted-sacrocolpopexy-for-pelvic-organ-prolapse-a-systematic-review
#14
Geertje Callewaert, Jan Bosteels, Susanne Housmans, Jasper Verguts, Ben Van Cleynenbreugel, Frank Van der Aa, Dirk De Ridder, Ignace Vergote, Jan Deprest
The use of robot-assisted surgery (RAS) has gained popularity in the field of gynaecology, including pelvic floor surgery. To assess the benefits of RAS, we conducted a systematic review of randomized controlled trials comparing laparoscopic and robotic-assisted sacrocolpopexy. The Cochrane Library (1970-January 2015), MEDLINE (1966 to January 2015), and EMBASE (1974 to January 2015) were searched, as well as ClinicalTrials.gov and the International Clinical Trials Registry Platform. We identified two randomized trials (n = 78) comparing laparoscopic with robotic sacrocolpopexy...
2016: Gynecological Surgery
https://www.readbyqxmd.com/read/27219097/evaluating-fetal-head-dimension-changes-during-labor-using-open-magnetic-resonance-imaging
#15
Christian Bamberg, Jan Deprest, Nikhil Sindhwani, Ulf Teichgräberg, Felix Güttler, Joachim W Dudenhausen, Karim D Kalache, Wolfgang Henrich
AIM: Fetal skull molding is important for the adaptation of the head to the birth canal during vaginal delivery. Importantly, the fetal head must rotate around the maternal symphysis pubis. The goals of this analysis were to observe a human birth in real-time using an open magnetic resonance imaging (MRI) scanner and describe the fetal head configuration during expulsion. METHODS: Real-time cinematic MRI series (TSE single-shot sequence, TR 1600 ms, TE 150 ms) were acquired from the midsagittal plane of the maternal pelvis during the active second stage of labor at 37 weeks of gestation...
May 24, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27179367/slic-seg-a-minimally-interactive-segmentation-of-the-placenta-from-sparse-and-motion-corrupted-fetal-mri-in-multiple-views
#16
Guotai Wang, Maria A Zuluaga, Rosalind Pratt, Michael Aertsen, Tom Doel, Maria Klusmann, Anna L David, Jan Deprest, Tom Vercauteren, Sébastien Ourselin
Segmentation of the placenta from fetal MRI is challenging due to sparse acquisition, inter-slice motion, and the widely varying position and shape of the placenta between pregnant women. We propose a minimally interactive framework that combines multiple volumes acquired in different views to obtain accurate segmentation of the placenta. In the first phase, a minimally interactive slice-by-slice propagation method called Slic-Seg is used to obtain an initial segmentation from a single motion-corrupted sparse volume image...
December 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27163402/tissue-response-to-collagen-containing-polypropylene-meshes-in-an-ovine-vaginal-repair-model
#17
Saeedeh Darzi, Iva Urbankova, Kai Su, Jacinta White, Camden Lo, David Alexander, Jerome A Werkmeister, Caroline E Gargett, Jan Deprest
UNLABELLED: Pelvic Organ Prolapse (POP) is the herniation of pelvic organs into the vagina. Despite broad acceptance of mesh use in POP surgical repair, the complication rate is unacceptable. We hypothesized that collagen-containing polypropylene (PP) mesh types could modulate mesh-tissue integration and reduce long-term inflammation, thereby reducing mesh-associated complications. This study compared the long-term tissue response to an unmodified PP mesh and two collagen containing meshes in an ovine model which has similar pelvic anatomy and vaginal size to human...
July 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27148678/a-minimum-of-1-year-follow-up-for-miniarc-single-incision-slings-compared-to-monarc-transobturator-slings-an-analysis-to-evaluate-durability-of-continence-and-medium-term-outcomes
#18
Manuela Tutolo, Dirk J M K De Ridder, Francesco Montorsi, Giulia Castagna, Jan Deprest, Renè P Schellart, Enrico Ammirati, Frank Van Der Aa
AIMS: To compare efficacy and safety of two commercially available single incision slings (SIS) and trans-obturator vaginal tapes (TOT), namely MiniArc™ and Monarc™ slings, and report the results at 5-year follow-up. METHODS: A retrospective-observational study of prospectively collected data was conducted on 381 women with primary stress urinary incontinence (SUI) in a single tertiary referral center. Patients treated with MiniArc™ and Monarc™ were compared...
May 5, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27077664/standardized-postnatal-management-of-infants-with-congenital-diaphragmatic-hernia-in-europe-the-cdh-euro-consortium-consensus-2015-update
#19
Kitty G Snoek, Irwin K M Reiss, Anne Greenough, Irma Capolupo, Berndt Urlesberger, Lucas Wessel, Laurent Storme, Jan Deprest, Thomas Schaible, Arno van Heijst, Dick Tibboel
In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after a gestational age of 39 weeks in a high-volume tertiary center; (2) neuromuscular blocking agents to be avoided during initial treatment in the delivery room; (3) adapt treatment to reach a preductal saturation of between 80 and 95% and postductal saturation >70%; (4) target PaCO2 to be between 50 and 70 mm Hg; (5) conventional mechanical ventilation to be the optimal initial ventilation strategy, and (6) intravenous sildenafil to be considered in CDH patients with severe pulmonary hypertension...
2016: Neonatology
https://www.readbyqxmd.com/read/27073886/the-impact-of-entry-technique-and-access-diameter-on-prelabour-rupture-of-membranes-following-primary-fetoscopic-laser-treatment-for-twin-twin-transfusion-syndrome
#20
Scott G Petersen, Kristen S Gibbons, Francois I Luks, Liesbeth Lewi, Anke Diemert, Kurt Hecher, Jan E Dickinson, Julien J Stirnemann, Yves Ville, Roland Devlieger, Glenn Gardener, Jan A Deprest
OBJECTIVE: To evaluate the impact of entry method and access diameter at fetoscopic surgery for twin-twin transfusion syndrome in twin pregnancies with at least one survivor. The outcomes evaluated were prelabour rupture of membranes (PROM) and birth <4 weeks, preterm birth (PTB) <28 weeks, and latency to birth. METHODS: A retrospective analysis of prospectively collected data of consecutive laser procedures from 6 centers was performed. Three entry methods (sheath + trocar; cannula + trocar; cannula + Seldinger) and 6 access diameters (2...
2016: Fetal Diagnosis and Therapy
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