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JOURNAL ARTICLE
Laura Cattani, Dominique Van Schoubroeck, Christine De Bruyn, Sophie Ghesquière, Jan Deprest
OBJECTIVE: To determine the prevalence of pelvic floor dysfunction (PFD) among pregnant women, their clustering and their association with body image disturbance (BID) up to 1 year postpartum. DESIGN: Monocentric prospective cohort study. SETTING: University Hospitals Leuven. POPULATION: Pregnant women attending for pregnancy care, first assessed prior to 14 weeks of gestation and agreeing to follow-up until 1 year postpartum...
April 16, 2024: BJOG: An International Journal of Obstetrics and Gynaecology
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JOURNAL ARTICLE
Kanokwaroon Watananirun, Anna M L F Vargas, Simen Vergote, Liesbeth Lewi, Marcelo O L Filippo, Peter McCulloch, Roland Devlieger, Cleisson F A Peralta, Jan Deprest
OBJECTIVE: To investigate whether prenatal repair of spina bifida aperta through mini-hysterotomy results in less prematurity, as compared to standard hysterotomy, when adjusting for known prematurity risks. METHODS: We performed a bi-centric, propensity score matched, controlled study, that is, adjusting for factors earlier reported to result in premature delivery or membrane rupture, in consecutive women having prenatal repair either through stapled hysterotomy or sutured mini-hysterotomy (≤3...
March 19, 2024: Prenatal Diagnosis
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Emma Umans, Kobe Dewilde, Helena Williams, Jan Deprest, Thierry Van den Bosch
INTRODUCTION: ultrasonography in the first trimester of pregnancy offers an early screening tool to identify high risk pregnancies. Artificial intelligence (AI) algorithms have the potential to improve the accuracy of diagnosis and assist the clinician in early risk stratification. OBJECTIVE: to conduct a systematic review of the use of AI in ultrasonography in the first trimester of pregnancy. METHODS: We conducted a systematic literature review by searching in computerised databases Pubmed, Embase and Google Scholar from inception to January 2024...
March 16, 2024: Fetal Diagnosis and Therapy
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JOURNAL ARTICLE
Mattia Francesco Maria Gerli, Giuseppe Calà, Max Arran Beesley, Beatrice Sina, Lucinda Tullie, Kylin Yunyan Sun, Francesco Panariello, Federica Michielin, Joseph R Davidson, Francesca Maria Russo, Brendan C Jones, Dani Do Hyang Lee, Savvas Savvidis, Theodoros Xenakis, Ian C Simcock, Anna A Straatman-Iwanowska, Robert A Hirst, Anna L David, Christopher O'Callaghan, Alessandro Olivo, Simon Eaton, Stavros P Loukogeorgakis, Davide Cacchiarelli, Jan Deprest, Vivian S W Li, Giovanni Giuseppe Giobbe, Paolo De Coppi
Isolation of tissue-specific fetal stem cells and derivation of primary organoids is limited to samples obtained from termination of pregnancies, hampering prenatal investigation of fetal development and congenital diseases. Therefore, new patient-specific in vitro models are needed. To this aim, isolation and expansion of fetal stem cells during pregnancy, without the need for tissue samples or reprogramming, would be advantageous. Amniotic fluid (AF) is a source of cells from multiple developing organs. Using single-cell analysis, we characterized the cellular identities present in human AF...
March 4, 2024: Nature Medicine
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JOURNAL ARTICLE
Mirza A Ahmad, Kanokwaroon Watananirun, Felix De Bie, Ann-Sophie Page, Paolo DE Coppi, Simen Vergote, Tom Vercauteren, Emmanuel Vander Poorten, Luc Joyeux, Jan Deprest
BACKGROUND: Fetoscopic Spina Bifida repair (fSB-repair) is increasingly being practiced, but limited skill acquisition poses a barrier to widespread adoption. Extensive training in relevant models, including both ex- and in-vivo models may help. To address this, a synthetic training model that is affordable, realistic and allows skill analysis would be useful. OBJECTIVE: To create a high-fidelity model for training the essential neurosurgical steps of fetoscopic spina bifida repair using synthetic materials...
January 15, 2024: American journal of obstetrics & gynecology MFM
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JOURNAL ARTICLE
Lucas Fidon, Michael Aertsen, Florian Kofler, Andrea Bink, Anna L David, Thomas Deprest, Doaa Emam, Frederic Guffens, Andras Jakab, Gregor Kasprian, Patric Kienast, Andrew Melbourne, Bjoern Menze, Nada Mufti, Ivana Pogledic, Daniela Prayer, Marlene Stuempflen, Esther Van Elslander, Sebastien Ourselin, Jan Deprest, Tom Vercauteren
Deep learning models for medical image segmentation can fail unexpectedly and spectacularly for pathological cases and images acquired at different centers than training images, with labeling errors that violate expert knowledge. Such errors undermine the trustworthiness of deep learning models for medical image segmentation. Mechanisms for detecting and correcting such failures are essential for safely translating this technology into clinics and are likely to be a requirement of future regulations on artificial intelligence (AI)...
January 10, 2024: IEEE Transactions on Pattern Analysis and Machine Intelligence
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JOURNAL ARTICLE
Mirza A Ahmad, Simen Vergote, Emmanuel Vander Poorten, Roland Devlieger, Paolo De Coppi, Edoardo Mazza, Jan Deprest
OBJECTIVE: To estimate stresses and strains in the uterine wall and fetal membranes with single/multi-port fetoscopy, simulating either a percutaneous access or via exteriorized uterus. STUDY DESIGN: Finite element models based on anatomical dimensions, material properties and boundary conditions were created to simulate stresses, strains and displacements on the uterine wall and fetal membranes during simulated fetal surgery either via exteriorized uterus or percutaneous approach, and with one or three cannulas...
January 7, 2024: Prenatal Diagnosis
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JOURNAL ARTICLE
Simen Vergote, Serjosha Robmann, Johannes Van Der Merwe, Jute Richter, Jan Deprest, Eduardo Mazza
OBJECTIVE: To compare the biomechanical properties of fetal preterm membranes (20 + 0 weeks to 30 + 0 weeks) to those of the term (37 + 0 to 41 + 0 weeks). METHOD: Amnion and chorion were manually separated and samples were cut to the required geometry. Rectangular samples with (mode 1) and without (uniaxial) a notch, were tested for tearing energy, critical elongation, and tangent stiffness. Suture retention and inter-suture distance testing investigated the effect of suture placement...
January 2, 2024: Prenatal Diagnosis
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JOURNAL ARTICLE
Sophia Bano, Alessandro Casella, Francisco Vasconcelos, Abdul Qayyum, Abdesslam Benzinou, Moona Mazher, Fabrice Meriaudeau, Chiara Lena, Ilaria Anita Cintorrino, Gaia Romana De Paolis, Jessica Biagioli, Daria Grechishnikova, Jing Jiao, Bizhe Bai, Yanyan Qiao, Binod Bhattarai, Rebati Raman Gaire, Ronast Subedi, Eduard Vazquez, Szymon Płotka, Aneta Lisowska, Arkadiusz Sitek, George Attilakos, Ruwan Wimalasundera, Anna L David, Dario Paladini, Jan Deprest, Elena De Momi, Leonardo S Mattos, Sara Moccia, Danail Stoyanov
Fetoscopy laser photocoagulation is a widely adopted procedure for treating Twin-to-Twin Transfusion Syndrome (TTTS). The procedure involves photocoagulation pathological anastomoses to restore a physiological blood exchange among twins. The procedure is particularly challenging, from the surgeon's side, due to the limited field of view, poor manoeuvrability of the fetoscope, poor visibility due to amniotic fluid turbidity, and variability in illumination. These challenges may lead to increased surgery time and incomplete ablation of pathological anastomoses, resulting in persistent TTTS...
December 20, 2023: Medical Image Analysis
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EDITORIAL
Jan Deprest, Tim Van Mieghem
No abstract text is available yet for this article.
December 2023: Prenatal Diagnosis
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JOURNAL ARTICLE
Felix R De Bie, Yannick Regin, Antoine Dubois, Marianna Scuglia, Tomohiro Arai, Ewout Muylle, David Basurto, Marius Regin, Siska Croubels, Marc Cherlet, Emily A Partridge, Karel Allegaert, Francesca M Russo, Jan A Deprest
Congenital diaphragmatic hernia (CDH) is a congenital malformation characterized by pulmonary hypoplasia, pulmonary hypertension, and cardiac dysfunction. Pulmonary hypertension represents the major cause of neonatal mortality and morbidity. Prenatal diagnosis allows assessment of severity and selection of foetal surgery candidates. We have shown that treprostinil, a prostacyclin analogue with an anti-remodelling effect, attenuates the relative hypermuscularization of the pulmonary vasculature in rats with nitrofen-induced CDH...
December 11, 2023: Biomedicine & Pharmacotherapy
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JOURNAL ARTICLE
Alessandro Casella, Sophia Bano, Francisco Vasconcelos, Anna L David, Dario Paladini, Jan Deprest, Elena De Momi, Leonardo S Mattos, Sara Moccia, Danail Stoyanov
PURPOSE: In twin-to-twin transfusion syndrome (TTTS), abnormal vascular anastomoses in the monochorionic placenta can produce uneven blood flow between the two fetuses. In the current practice, TTTS is treated surgically by closing abnormal anastomoses using laser ablation. This surgery is minimally invasive and relies on fetoscopy. Limited field of view makes anastomosis identification a challenging task for the surgeon. METHODS: To tackle this challenge, we propose a learning-based framework for in vivo fetoscopy frame registration for field-of-view expansion...
December 9, 2023: International Journal of Computer Assisted Radiology and Surgery
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JOURNAL ARTICLE
A-G Cordier, D A Badr, D Basurto, F Russo, J Deprest, E Orain, E Eixarch, J Otano, E Gratacos, A Moraes De Luna Freire Vargas, C F A Peralta, J C Jani, A Benachi
OBJECTIVE: Few fetal malformations benefit from in utero surgery. One of the major drawbacks of fetal surgery is preterm premature rupture of membranes (PPROM). Morbidity associated with congenital diaphragmatic hernia (CDH) is primarily respiratory but also gastrointestinal and induced prematurity are likely to worsens those complications. To assess whether or not the cannula insertion site on the maternal abdomen during fetoscopic endoluminal tracheal occlusion (FETO) was associated with PPROM before balloon removal...
December 5, 2023: Ultrasound in Obstetrics & Gynecology
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JOURNAL ARTICLE
Ignacio Valenzuela, Yannick Regin, Andre Gie, David Basurto, Doaa Emam, Marianna Scuglia, Katerina Zapletalova, Marnel Greyling, Jan Deprest, Johannes van der Merwe
Fetal growth restriction (FGR) remains one of the main obstetrical problems worldwide, with consequences beyond perinatal life. Animal models with developmental and structural similarities to the human are essential to understand FGR long-term consequences and design novel therapeutic strategies aimed at preventing or ameliorating them. Herein, we described the long-term consequences of FGR in pulmonary function, structure, and gene expression, and characterized neurodevelopmental sequelae up to preadolescence in a rabbit model...
November 28, 2023: Scientific Reports
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JOURNAL ARTICLE
Mirza Awais Ahmad, Yolan Weiler, Luc Joyeux, Elisenda Eixarch, Tom Vercauteren, Sebastien Ourselin, Jan Deprest, Emmanuel Vander Poorten
3D imaging technology is becoming more prominent every day. However, more validation is needed to understand the actual benefit of 3D versus conventional 2D vision. This work quantitatively investigates whether experts benefit from 3D vision during minimally invasive fetoscopic spina bifida (fSB) repair. A superiority study was designed involving one expert team ([Formula: see text] procedures prior) who performed six 2D and six 3D fSB repair simulations in a high-fidelity animal training model, using 3-port access...
November 28, 2023: Scientific Reports
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REVIEW
Yair J Blumenfeld, Kunj R Sheth, Eric Johnson, James K Wall, Jan A Deprest, Francesca M Russo, Enrico Danzer
Fetal lower urinary tract obstruction (LUTO) is a severe malformation associated with an up to 80% mortality risk as well as significant renal and pulmonary morbidity in survivors. Fetal vesico-amniotic shunts (VAS) bypass the bladder obstruction, improve amniotic fluid volume and enhance in-utero pulmonary development. VAS has been shown to reduce respiratory morbidity and mortality in the neonatal period without proven benefit on long-term renal and bladder function. Clinically available shunts are associated with an up to 80% dislodgement rate, leading to repeat invasive procedures which increase fetal and maternal risks...
November 27, 2023: Prenatal Diagnosis
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JOURNAL ARTICLE
Nada Mufti, Michael Aertsen, Dominic Thomson, Phillippe De Vloo, Philippe Demaerel, Jan Deprest, Andrew Melbourne, Anna L David
INTRODUCTION: Fetal surgery for open spina bifida (OSB) requires comprehensive preoperative assessment using imaging for appropriate patient selection and to evaluate postoperative efficacy and complications. We explored patient access and conduct of fetal magnetic resonance imaging (MRI) for prenatal assessment of OSB patients eligible for fetal surgery. We compared imaging acquisition and reporting to the International Society of Ultrasound in Obstetrics and Gynecology MRI performance guidelines...
November 20, 2023: Acta Obstetricia et Gynecologica Scandinavica
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JOURNAL ARTICLE
Katerina Zapletalova, Ignacio Valenzuela, Marnel Greyling, Yannick Regin, Cristian Frigolett, Ladislav Krofta, Jan Deprest, Johannes van der Merwe
Fetal growth restriction (FGR) remains without an effective prenatal treatment. Evidence from murine FGR models suggests a beneficial effect of prenatal pravastatin. Since the rabbit hemodichorial placenta more closely resembles the human condition, we investigated the effects of prenatal maternal pravastatin administration in the rabbit FGR model. At a gestational age of 25 days (term 31d), pregnant dams underwent partial uteroplacental vessel ligation (UPVL) in one uterine horn to induce FGR, leaving the other horn as a control...
September 30, 2023: Biomedicines
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JOURNAL ARTICLE
Chloe N Cordes, Melissa M Gouge, Hannah Morgan, Carah Porter, Jamie Siders, Erica Bacab, Briana Barin, Ixel A Becerra, Jose Castillo, Jared Church, Shaunacee Condo-Hicks, Kattleya J Conroy, Isbel Curbelo-Navarro, Benjamin J DePrest, Adrienne Eady, TyMahni Edmead, Verena Farouk, Angelica Flores-Torres, Michael Girmai, Cynthia I Gutierrez Navarro, Stan Guzman, Alexis B Harris, Karin Healy, Alina Jaafar, Abraham Khadr, Melissa N Kiboi, Stephanie N Korte, Celia Lopez, Hyder Mahdi, Jennifer Mendoza Avalos, Kathy Miranda, Dipti Patel, Celia Lopez, Hyder Mahdi, Jennifer Mendoza Avalos, Kathy Miranda, Dipti Patel, Rishi Patel, Sydney Pechulis, Victoria Plachta, Kamryn Rhodes, Andrea M Sandoval, Caila Thomas, Joselyn A Valadez-Mendoza, Hannah Vora, Jonathan Yousif, Kayla L Bieser, Jacob D Kagey
An EMS-based forward genetic screen was conducted in an apoptotic null background to identify genetic aberrations that contribute to regulation of cell growth in Drosophila melanogaster . The current work maps the genomic location of one of the identified mutants, L.3.2 . Genetic crosses conducted through the Fly-CURE consortium determined that the gene locus for the L.3.2 mutation is p47 on chromosome 2R.
2023: microPublication. Biology
#20
Oluwatosin Alabi, Sophia Bano, Francisco Vasconcelos, Anna L David, Jan Deprest, Danail Stoyanov
No abstract text is available yet for this article.
October 3, 2023: International Journal of Computer Assisted Radiology and Surgery
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