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https://www.readbyqxmd.com/read/28342715/prediction-of-neonatal-respiratory-morbidity-by-quantitative-ultrasound-lung-texture-analysis-a-multicenter-study
#1
Montse Palacio, Elisenda Bonet-Carne, Teresa Cobo, Alvaro Perez-Moreno, Joan Sabrià, Jute Richter, Marian Kacerovsky, Bo Jacobsson, Raúl A García-Posada, Fernando Bugatto, Ramon Santisteve, Àngels Vives, Mauro Parra-Cordero, Edgar Hernandez-Andrade, José Luis Bartha, Pilar Carretero-Lucena, Kai Lit Tan, Rogelio Cruz-Martínez, Minke Burke, Suseela Vavilala, Igor Iruretagoyena, Juan Luis Delgado, Mauro Schenone, Josep Vilanova, Francesc Botet, George Sh Yeo, Jon Hyett, Jan Deprest, Roberto Romero, Eduard Gratacos
BACKGROUND: Prediction of neonatal respiratory morbidity may be useful to plan delivery in complicated pregnancies. The limited predictive performance of the current diagnostic tests together with the risks of an invasive procedure, limit the use of fetal lung maturity assessment. OBJECTIVE: To evaluate the performance of quantitative ultrasound texture analysis (quantusFLM®) to predict neonatal respiratory morbidity in preterm and early-term (<39.0 weeks) deliveries ...
March 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28287588/medical-grade-sterilizable-target-for-fluid-immersed-fetoscope-optical-distortion-calibration
#2
Daniil I Nikitichev, Dzhoshkun I Shakir, François Chadebecq, Marcel Tella, Jan Deprest, Danail Stoyanov, Sébastien Ourselin, Tom Vercauteren
We have developed a calibration target for use with fluid-immersed endoscopes within the context of the GIFT-Surg (Guided Instrumentation for Fetal Therapy and Surgery) project. One of the aims of this project is to engineer novel, real-time image processing methods for intra-operative use in the treatment of congenital birth defects, such as spina bifida and the twin-to-twin transfusion syndrome. The developed target allows for the sterility-preserving optical distortion calibration of endoscopes within a few minutes...
February 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28277906/preclinical-evaluation-of-cell-based-strategies-to-prevent-or-treat-bronchopulmonary-dysplasia-in-animal-models-a-systematic-review
#3
Flore Lesage, Julio Jimenez, Jaan Toelen, Jan Deprest
Bronchopulmonary dysplasia (BPD) remains the most common complication of extreme prematurity as no effective treatment is available to date. This calls for the exploration of new therapeutic options like cell therapy, which is already effective for various human (lung) disorders. We systematically searched the MEDLINE, Embase and Web of Science databases from the earliest date till January 2017 and included original studies on the perinatal use of cell-based therapies (i.e. cells and/or cell-derivatives) to treat BDP in animal models...
March 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28267443/balloon-removal-after-fetoscopic-endoluminal-tracheal-occlusion-for-congenital-diaphragmatic-hernia
#4
Julio A Jiménez, Elisenda Eixarch, Philip Dekoninck, João R Bennini, Roland Devlieger, Cleisson F Peralta, Eduard Gratacos, Jan Deprest
BACKGROUND: Isolated congenital diaphragmatic hernia (CDH) defect allows viscera to herniate into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients. Antenatal measurement of lung size and liver herniation can predict survival after birth. Prenatal intervention aims at stimulating lung development, clinically achieved by percutaneous fetal endoscopic tracheal occlusion (FETO) under local anesthesia...
March 3, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28205301/in-case-you-missed-it-the-prenatal-diagnosis-editors-bring-you-the-most-significant-advances-of-2016
#5
EDITORIAL
Tim Van Mieghem, Diana W Bianchi, Brynn Levy, Jan Deprest, Lyn S Chitty, Alessandro Ghidini
No abstract text is available yet for this article.
February 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28196368/pericardio-amniotic-shunting-for-incomplete-pentalogy-of-cantrell
#6
Alexander C Engels, Anne Debeer, Francesca M Russo, Michael Aertsen, Katleen Aerts, Marc Miserez, Jan Deprest, Liesbeth Lewi, Roland Devlieger
A 27-year-old woman, gravida 2, para 0, presented with an incomplete Pentalogy of Cantrell with an omphalocele, diaphragmatic hernia, and a pericardial defect at 32 weeks' gestation. A large pericardial effusion compressed the lungs and had led to a reduced lung growth with an observed-to-expected total lung volume of 28% as measured by MRI. The effusion disappeared completely after the insertion of a pericardio-amniotic shunt at 33 weeks. After birth, the newborn showed no signs of pulmonary hypoplasia and underwent a surgical correction of the defect...
2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28187889/gift-cloud-a-data-sharing-and-collaboration-platform-for-medical-imaging-research
#7
Tom Doel, Dzhoshkun I Shakir, Rosalind Pratt, Michael Aertsen, James Moggridge, Erwin Bellon, Anna L David, Jan Deprest, Tom Vercauteren, Sébastien Ourselin
OBJECTIVES: Clinical imaging data are essential for developing research software for computer-aided diagnosis, treatment planning and image-guided surgery, yet existing systems are poorly suited for data sharing between healthcare and academia: research systems rarely provide an integrated approach for data exchange with clinicians; hospital systems are focused towards clinical patient care with limited access for external researchers; and safe haven environments are not well suited to algorithm development...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28125816/comparative-anatomy-of-the-ovine-and-female-pelvis
#8
Iva Urbankova, Katarina Vdoviakova, Rita Rynkevic, Nikhil Sindhwani, Dries Deprest, Andrew Feola, Paul Herijgers, Ladislav Krofta, Jan Deprest
BACKGROUND: Pelvic organ prolapse affects half of vaginally parous women. Several animal models are used to study its pathophysiology and treatment. Sheep are interesting because they develop spontaneously prolapse with similar risk factors as women and can be used for vaginal surgery. This study describes ovine pelvis anatomy and compares it to women's pelvis to provide anatomical tools for translational researchers. METHODS: MRI, pelvic dissections, and histology were used for detailed macro- and microscopic analysis of relevant anatomical structures in 6 nulliparous ewes...
January 27, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27968707/enantiomer-specific-ketorolac-pharmacokinetics-in-young-women-including-pregnancy-and-postpartum-period
#9
Aida Kulo, Anne Smits, Sanita Maleškić, Marc Van de Velde, Kristel Van Calsteren, Jan De Hoon, Rene Verbesselt, Jan Deprest, Karel Allegaert
Racemic ketorolac clearance (CL) is significantly higher at delivery, but S-ketorolac disposition determines the analgesic effects. The aim of this study was to investigate the effect of pregnancy and postpartum period on enantiomer-specific (S and R) intravenous (IV) ketorolac pharmacokinetics (PKs). Data in women shortly following cesarean delivery (n=39) were pooled with data in a subgroup of these women that was reevaluated in the later postpartum period (postpartum group, n=8/39) and with eight healthy female volunteers...
February 21, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27862078/current-controversies-in-prenatal-diagnosis-1-in-utero-therapy-for-spina-bifida-is-ready-for-endoscopic-repair
#10
Michael Belfort, Jan Deprest, Kurt Hecher
No abstract text is available yet for this article.
December 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27783043/progressive-vascular-functional-and-structural-damage-in-a-bronchopulmonary-dysplasia-model-in-preterm-rabbits-exposed-to-hyperoxia
#11
Julio Jiménez, Jute Richter, Taro Nagatomo, Thomas Salaets, Rozenn Quarck, Allard Wagennar, Hongmei Wang, Jeroen Vanoirbeek, Jan Deprest, Jaan Toelen
Bronchopulmonary dysplasia (BPD) is caused by preterm neonatal lung injury and results in oxygen dependency and pulmonary hypertension. Current clinical management fails to reduce the incidence of BPD, which calls for novel therapies. Fetal rabbits have a lung development that mimics humans and can be used as a translational model to test novel treatment options. In preterm rabbits, exposure to hyperoxia leads to parenchymal changes, yet vascular damage has not been studied in this model. In this study we document the early functional and structural changes of the lung vasculature in preterm rabbits that are induced by hyperoxia after birth...
October 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27644443/abstracts-of-the-26th-world-congress-on-ultrasound-in-obstetrics-and-gynecology-rome-italy-24-28-september-2016
#12
M Yamamoto, V Dezerega, J Jimenez, J Astudillo, J Deprest
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27568096/connexin-43-is-overexpressed-in-human-fetal-membrane-defects-after-fetoscopic-surgery
#13
David W Barrett, Anna L David, Christopher Thrasivoulou, Alvaro Mata, David L Becker, Alex C Engels, Jan A Deprest, Tina T Chowdhury
OBJECTIVE: We examined whether surgically induced membrane defects elevate connexin 43 (Cx43) expression in the wound edge of the amniotic membrane (AM) and drives structural changes in collagen that affects healing after fetoscopic surgery. METHOD: Cell morphology and collagen microstructure was investigated by scanning electron microscopy and second harmonic generation in fetal membranes taken from women who underwent fetal surgery. Immunofluoresence and real-time quantitative polymerase chain reaction was used to examine Cx43 expression in control and wound edge AM...
October 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27567969/a-novel-translational-model-for-fetoscopic-intratracheal-delivery-of-nanoparticles-in-piglets
#14
Marianne S Carlon, Alexander C Engels, Barbara Bosch, Luc Joyeux, Marina G M C Mori da Cunha, Dragana Vidović, Zeger Debyser, Kris De Boeck, Arne Neyrinck, Jan A Deprest
OBJECTIVES: The aim of this study was to assess the feasibility of fetal tracheal injection in the late-gestational pig to target the airways. METHODS: Following laparotomy and hysterotomy, fetoscopy was performed in pregnant sows to access the fetal trachea. Two volumes of fluospheres were injected (1 and 3 mL). Fluosphere distribution to the different lung lobes was investigated by microscopy. Possible fetal airway injury, caused by the surgical procedure or intratracheal injection, was investigated...
October 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27567616/proton-pump-inhibitor-omeprazole-attenuates-hyperoxia-induced-lung-injury
#15
Jute Richter, Julio Jimenez, Taro Nagatomo, Jaan Toelen, Paul Brady, Thomas Salaets, Flore Lesage, Jeroen Vanoirbeek, Jan Deprest
BACKGROUND: The administration of supplemental oxygen to treat ventilatory insufficiency may lead to the formation of reactive oxygen species and subsequent tissue damage. Cytochrome P4501A1 (CYP1A1) can modulate hyperoxic lung injury by a currently unknown mechanism. Our objective was to evaluate the effect of administration of omeprazole on the induction of CYP1A1 and its influence on hyperoxic lung injury in an established preterm rabbit model. METHODS: Omeprazole was administered either (1) directly to the fetus, (2) to the mother or (3) after birth to the pups in different doses (2-10 or 20 mg/kg)...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27548820/vascular-endothelial-growth-factor-up-regulation-in-human-amniotic-fluid-stem-cell-enhances-nephroprotection-after-ischemia-reperfusion-injury-in-the-rat
#16
Marina Gabriela Monteiro Carvalho Mori da Cunha, Silvia Zia, Diego Vilibaldo Beckmann, Marianne Sylvia Carlon, Fanny Oliveira Arcolino, Maarten Albersen, Ney Luis Pippi, Dominguita Lühers Graça, Conny Gysemans, Peter Carmeliet, Elena Levtchenko, Jan Deprest, Jaan Toelen
OBJECTIVE: To evaluate if the up-regulation of vascular endothelial growth factor strengthens the protective effect of amniotic fluid stem cells in a renal ischemia-reperfusion injury model. DESIGN: Randomized animal study. SETTINGS: University research laboratory. SUBJECTS: A total of 40 males 12-week-old Wistar rats were subjected to ischemia-reperfusion and assigned to four groups: amniotic fluid stem cells, vascular endothelial growth factor-amniotic fluid stem cells in two different doses, and vehicle...
January 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/27533315/esophageal-atresia-future-directions-for-research-on-the-digestive-tract
#17
Maissa Rayyan, Nathalie Rommel, Jan Tack, Jan Deprest, Karel Allegaert
Esophageal atresia (EA) is a congenital malformation defined by the discontinuity of the esophagus occurring in 2.4 in 10,000 births. As survival rates are high, the significant medical morbidity became more relevant. Short-term and long-term morbidities involve the respiratory and gastrointestinal system in the majority of the patients. The impact of this morbidity seems large enough to inspire researchers to develop experimental animal models that may help understanding the pathogenesis and pathophysiology...
August 17, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27478427/gynaecological-endoscopic-surgical-education-and-assessment-a-diploma-programme-in-gynaecological-endoscopic-surgery
#18
Rudi Campo, Arnaud Wattiez, Vasilis Tanos, Attilio Di Spiezio Sardo, Grigoris Grimbizis, Diethelm Wallwiener, Sara Brucker, Marco Puga, Roger Molinas, Peter O'Donovan, Jan Deprest, Yves Van Belle, Ann Lissens, Anja Herrmann, Mahmood Tahir, Chiara Benedetto, Igno Siebert, Benoit Rabischong, Rudy Leon De Wilde
In recent years, training and education in endoscopic surgery has been critically reviewed. Clinicians, both surgeons as gynaecologist who perform endoscopic surgery without proper training of the specific psychomotor skills, are at higher risk to increased patient morbidity and mortality. Although the apprentice-tutor model has long been a successful approach for training of surgeons, recently, clinicians have recognised that endoscopic surgery requires an important training phase outside the operating theatre...
2016: Gynecological Surgery
https://www.readbyqxmd.com/read/27381265/the-2015-malcolm-ferguson-smith-young-investigator-award
#19
EDITORIAL
Alessandro Ghidini, Diana W Bianchi, Brynn Levy, Jan Deprest, Tim van Mieghem, Lyn S Chitty, Amanda McLean-Inglis
No abstract text is available yet for this article.
July 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27378767/fertility-pregnancy-and-gynecological-outcomes-after-fetoscopic-surgery-for-congenital-diaphragmatic-hernia
#20
C Gregoir, A C Engels, O Gomez, P DeKoninck, L Lewi, E Gratacos, J A Deprest
STUDY QUESTION: What is the impact of fetoscopic surgery for isolated Congenital Diaphragmatic Hernia (CDH) on future reproductive and gynecological outcomes? SUMMARY ANSWER: We did not observe an increase of obstetric or gynecological problems after fetoscopic surgery nor was there an increased risk for subsequent infertility. WHAT IS KNOWN ALREADY: The reproductive and gynecological outcomes of patients undergoing open maternal-fetal surgery are known...
September 2016: Human Reproduction
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