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https://www.readbyqxmd.com/read/28081060/erratum-vol-65-nos-50-51
#1
(no author information available yet)
In the report "Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015" in both "TABLE 1. Number and age-adjusted rate of drug overdose deaths* involving natural and semisynthetic opioids(†) and methadone,(§,¶) by sex, age group, race/ethnicity,** U.S. Census region, and selected states(††) - United States, 2014 and 2015," and in "TABLE 2. Number and age-adjusted rate of drug overdose deaths* involving synthetic opioids other than methadone(†) and heroin,(§,¶) by sex, age group, race/ethnicity,** U...
January 13, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28076550/suicide-in-university-students-in-bogot%C3%A3-colombia-2004-2014
#2
Saúl Alonso Franco, Martha Lucia Gutiérrez, Julián Sarmiento, Decsy Cuspoca, Javier Tatis, Alejandro Castillejo, Miguel Barrios, Magnolia Del Pilar Ballesteros-Cabrera, Sara Zamora, Carlos Iván Rodríguez
We report the results of a retrospective, descriptive, qualitative study of suicide among university students in Bogotá, Colombia. The objective of this study was to document the magnitude, principal characteristics, and impact of this phenomenon in the selected population. A semi-structured survey was employed to collect information from 66 individuals linked to the universities. A total of 45 cases of suicide were documented in the study period (2004 - 2014). Of these, 69% occurred in males and 31% in females...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28076304/the-use-of-liquid-chromatography-tandem-mass-spectrometry-for-therapeutic-drug-monitoring-of-antibiotics-in-cancer-patients
#3
Nahed El-Najjar, Jonathan Jantsch, André Gessner
Cancer remains a leading cause of mortality and morbidity worldwide. In addition to organ failure, the most frequent reasons for admission of cancer patients to intensive care units (ICU) are: infections and sepsis. As critically ill, the complexity of the health situation of cancer patients renders the standard antimicrobial regimen more complex and even inadequate which results in increased mortality rates. This is due to pathophysiological changes in the volume of distribution, increased clearance, as well as to organ dysfunction...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28072812/is-kratom-the-new-legal-high-on-the-block-the-case-of-an-emerging-opioid-receptor-agonist-with-substance-abuse-potential
#4
George C Chang-Chien, Charles A Odonkor, Prin Amorapanth
Kratom is an unscheduled opioid receptor agonist that comes in the form of dietary supplements currently being abused by chronic pain patients on prescription opioids. Active alkaloids isolated from kratom such as mitragynine and 7-hydroxymitragynine are thought to act on mu- and delta-opioid receptors as well as alpha-2 adrenergic and 5-HT2A receptors. Animal studies suggest that kratom may be more potent than morphine. Consequently, kratom consumption produces analgesic and euphoric feelings among users. In particular, some chronic pain patients on opioids take kratom to counteract the effects of opioid withdrawal...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28064509/acute-salicylate-poisoning-risk-factors-for-severe-outcome
#5
Rachel M Shively, Robert S Hoffman, Alex F Manini
CONTEXT: Salicylate poisoning remains a significant public health threat with more than 20,000 exposures reported annually in the United States. OBJECTIVE: We aimed to establish early predictors of severe in-hospital outcomes in Emergency Department patients presenting with acute salicylate poisoning. METHODS: This was a secondary data analysis of adult salicylate overdoses from a prospective cohort study of acute drug overdoses at two urban university teaching hospitals from 2009 to 2013...
January 9, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28060437/trajectories-of-heroin-use-10-11-year-findings-from-the-australian-treatment-outcome-study
#6
Maree Teesson, Christina Marel, Shane Darke, Joanne Ross, Tim Slade, Lucy Burns, Michael Lynskey, Sonja Memedovic, Joanne White, Katherine L Mills
AIMS: To identify trajectories of heroin use in Australia, predictors of trajectory group membership, and subsequent outcomes, among people with heroin dependence over 10-11-years. DESIGN: Longitudinal cohort study. SETTING: Sydney, Australia. PARTICIPANTS: 615 participants were recruited between 2001-2002 as part of the Australian Treatment Outcome Study (66.2% male; mean age 29). The predominance of the cohort (87...
January 6, 2017: Addiction
https://www.readbyqxmd.com/read/28056010/quickstats-rates-of-drug-overdose-deaths-involving-heroin-by-selected-age-groups-united-states-2006-2015
#7
(no author information available yet)
The rate of drug overdose deaths involving heroin increased slightly during 2006-2010 but more than tripled during 2010-2015 for all age groups shown. During 2010-2015, the rates increased from 1.2 to 3.8 per 100,000 for persons aged 15-24 years, from 2.2 to 9.7 for persons aged 25-34 years, from 1.6 to 7.4 for persons aged 35-44 years, from 1.4 to 5.6 for persons aged 45-54 years, and from 0.7 to 3.4 for persons aged 55-64 years. In 2015, the rate of drug overdose deaths involving heroin was highest for persons aged 25-34...
January 6, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28053591/potentially-inappropriate-medications-prescribed-for-elderly-patients-through-family-physicians
#8
Abdulaziz Al Odhayani, Ayla Tourkmani, Mohammed Alshehri, Hala Alqahtani, Adel Mishriky
The elderly population is increasing throughout the globe, resulting in higher healthcare costs. Potential inappropriate medication (PIM) prescriptions are a major health problem affecting the elderly persons. Due to limited studies in PIM use in primary care and home healthcare in Saudi Arabia, we aim to examine the extent of PIM prescription for and use by elderly patients. This study was carried out with 798 elderly patients, arbitrarily selected from Prince Sultan Medical Military City through the patient register...
January 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28051839/social-context-and-perspectives-of-non-medical-prescription-opioid-use-among-young-adults-in-rhode-island-a-qualitative-study
#9
Jesse L Yedinak, Elizabeth N Kinnard, Scott E Hadland, Traci C Green, Melissa A Clark, Brandon D L Marshall
BACKGROUND AND OBJECTIVES: This pilot study examined the context of nonmedical prescription opioid (NMPO) use and related risk behaviors among young adults in Rhode Island, a New England region with markedly high prevalence of NMPO use and overdose mortality. METHODS: We conducted semi-structured interviews (n = 13) with young adults (18-29 year-olds) who reported current or recent NMPO use. We also conducted focus groups (two groups, n = 14 total) with professional service providers recruited from service organizations...
December 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/28044328/an-introduction-to-predictive-modelling-of-drug-concentration-in-anaesthesia-monitors
#10
REVIEW
J DeCou, K Johnson
A significant amount of anaesthetists' work involves the prediction of drug effects and interactions to produce a smooth general anaesthetic that minimises drug side effects and promotes rapid emergence. Successfully managing this process requires a basic understanding of drug effects, experience and inevitably some guesswork, since it is difficult (and in some cases impossible) to anticipate all relevant patient and surgical factors. Although data are generally available to allow calculation of plasma drug and effect site concentrations, this is often difficult to apply in complex clinical contexts, particularly when multiple drug types are used...
January 2017: Anaesthesia
https://www.readbyqxmd.com/read/28041610/-paediatric-pharmacobezoar-in-vitamin-overdose
#11
Nataliz Vega-Mata, Laura Fernández-García, Carolina Lara-Cardenas, Lucía Raposo-Rodríguez, María Montes-Granda
BACKGROUND: Pharmacobezoars are aggregates of undigested medications that accumulate in the gastrointestinal tract and can cause obstructive or toxic complications. In this paper, the first case is reported of a paediatric pharmacobezoar formation after a vitamin overdose. The objective of this report is to prevent the occurrence of this complication and the action to be taken. CLINIC CASE: A 6-year-old child, 6h after ingesting 40 chewable tablets of a hydrophobic vitamin E with high capacity to form a pharmacobezoar, underwent urgent oesophagogastroscopy...
December 29, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28040234/-regulation-of-hypnosis-in-propofol-anesthesia-administration-based-on-non-linear-control-strategy
#12
Muhammad Ilyas, Ali Khaqan, Jamshed Iqbal, Raja Ali Riaz
Continuous adjustment of Propofol in manual delivery of anesthesia for conducting a surgical procedure overburdens the workload of an anesthetist who is working in a multi-tasking scenario. Going beyond manual administration and Target Controlled Infusion, closed-loop control of Propofol infusion has the potential to offer several benefits in terms of handling perturbations and reducing the effect of inter-patient variability. This paper proposes a closed-loop automated drug administration approach to control Depth Of Hypnosis in anesthesia...
December 28, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28038759/-medication-errors-in-anesthesia-unacceptable-or-unavoidable
#13
Ira Dhawan, Anurag Tewari, Sankalp Sehgal, Ashish Chandra Sinha
Medication errors are the common causes of patient morbidity and mortality. It adds financial burden to the institution as well. Though the impact varies from no harm to serious adverse effects including death, it needs attention on priority basis since medication errors' are preventable. In today's world where people are aware and medical claims are on the hike, it is of utmost priority that we curb this issue. Individual effort to decrease medication error alone might not be successful until a change in the existing protocols and system is incorporated...
December 27, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28036135/circumstances-surrounding-non-fatal-opioid-overdoses-attended-by-ambulance-services
#14
Desiree Madah-Amiri, Thomas Clausen, Lars Myrmel, Guttorm Brattebø, Philipp Lobmaier
INTRODUCTION AND AIMS: Opioid overdose fatalities are a significant concern globally. Non-fatal overdoses have been described as a strong predictor for future overdoses, and are often attended by the ambulance services. This paper explores characteristics associated with non-fatal overdoses and aims to identify possible trends among these events in an urban area in Norway. DESIGN AND METHODS: This is a retrospective analysis of non-fatal overdoses from Bergen ambulance services from 2012 to 2013...
December 30, 2016: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28033313/increases-in-drug-and-opioid-involved-overdose-deaths-united-states-2010-2015
#15
Rose A Rudd, Puja Seth, Felicita David, Lawrence Scholl
The U.S. opioid epidemic is continuing, and drug overdose deaths nearly tripled during 1999-2014. Among 47,055 drug overdose deaths that occurred in 2014 in the United States, 28,647 (60.9%) involved an opioid (1). Illicit opioids are contributing to the increase in opioid overdose deaths (2,3). In an effort to target prevention strategies to address the rapidly changing epidemic, CDC examined overall drug overdose death rates during 2010-2015 and opioid overdose death rates during 2014-2015 by subcategories (natural/semisynthetic opioids, methadone, heroin, and synthetic opioids other than methadone)...
December 30, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28032224/asymmetric-c7-pedicle-subtraction-osteotomy-for-correction-of-rigid-cervical-coronal-imbalance-secondary-to-post-traumatic-heterotopic-ossification-a-case-report-description-of-a-novel-surgical-technique-and-literature-review
#16
Alexander A Theologis, Kate D Bellevue, Erion Qamirani, Christopher P Ames, Vedat Deviren
PURPOSE: Deformities of the cervical spine are uncommon in the coronal plane. In this report, a unique case of a 31-year-old male with a fixed, 30° left coronal deformity due to heterotopic ossification 3 years status post poly-trauma was treated with an asymmetric C7 pedicle subtraction osteotomy (PSO). METHODS: Case report. RESULTS: Pre-operatively, the patient had a fixed 45-degree left tilt of his neck and radiographs demonstrated a rigid 30° scoliosis, 7 cm coronal imbalance, and 4 cm negative sagittal balance, diffuse bridging bone between the spinous processes and the facet joints of C5 to T1 bilaterally...
December 28, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28031524/adenosine-5-monophosphate-blocks-acetaminophen-toxicity-by-increasing-ubiquitination-mediated-ask1-degradation
#17
Xiao Yang, Yibei Zhan, Qi Sun, Xi Xu, Yi Kong, Jianfa Zhang
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure in the world. Hepatic c-jun NH2-terminal protein kinase (JNK) activation is thought to be a consequence of oxidative stress produced during APAP metabolism. Activation of JNK signals causes hepatocellular damage with necrotic and apoptotic cell death. Here we found that APAP caused a feedback increase in plasma adenosine 5'-monophsphate (5'-AMP). We demonstrated that co-administration of APAP and 5'-AMP significantly ameliorated APAP-induced hepatotoxicity in mice, without influences on APAP metabolism and its analgesic function...
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/28031152/lycopene-pretreatment-improves-hepatotoxicity-induced-by-acetaminophen-in-c57bl-6-mice
#18
Ana Carla Balthar Bandeira, Rafaella Cecília da Silva, Joamyr Victor Rossoni, Vivian Paulino Figueiredo, André Talvani, Silvia Dantas Cangussú, Frank Silva Bezerra, Daniela Caldeira Costa
Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice...
December 18, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28030756/risk-factors-of-a-suicide-reattempt-by-seasonality-and-the-method-of-a-previous-suicide-attempt-a-cohort-study-in-a-japanese-primary-care-hospital
#19
Minoru Sawa, Hiraki Koishikawa, Yoneatsu Osaki
Suicide has a great impact on the individual whose life is lost and the bereaved family members. The risk of a suicide reattempt is particularly high during the first 12 months after a suicide attempt. In this cohort study, risk factors for a suicide reattempt were explored among 291 patients at suicide risk. Clinical and demographic data were collected from a Japanese primary care hospital. Past psychiatric history and multiple diagnoses were associated with suicide reattempts in both genders. Drug overdose, past psychiatric history, and the summer season were linked to suicide reattempts among males...
December 28, 2016: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28027483/experiences-of-peer-trainers-in-a-take-home-naloxone-program-results-from-a-qualitative-study
#20
Carley Marshall, Michel Perreault, Léonie Archambault, Diana Milton
BACKGROUND: Take-home naloxone programs (THN) are harm reduction programs with the aim of reducing the number of deaths caused by opioid overdoses. A THN program in Montreal called the PROFAN project was implemented with the goal of reducing overdoses through the use of peer-trainers. Peer-trainers are people who are currently or have previously used drugs, who are trained in overdose prevention and are then responsible for delivering a training session to other individuals who use drugs...
December 24, 2016: International Journal on Drug Policy
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