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Myocardio Infarction

Yu-Fan Yang, Ke Peng, Hong Liu, Xiao-Wen Meng, Jing-Jing Zhang, Fu-Hai Ji
Pharmacological preconditioning reduces myocardial infarct size in ischaemia-reperfusion (I-R) injury. Dexmedetomidine, a selective α2 -adrenoceptor agonist, has a proven cardioprotective effect when administered prior to I-R, although the underlying mechanisms for this effect are not fully understood. We evaluated whether dexmedetomidine preconditioning could induce a myocardio-protective effect against I-R injury by inhibiting associated inflammatory processes through downregulation of the high mobility group box 1 (HMGB1)-toll-like receptor 4 (TLR4)-nuclear factor κB (NF-κB) signalling pathway...
March 2017: Clinical and Experimental Pharmacology & Physiology
No abstract text is available yet for this article.
October 10, 1963: Minerva Medica
F D Loop, N R Carabajal, P C Taylor, M J Irarrazaval
Thirty-two consecutive patients who earlier received indirect or direct myocardial revascularization underwent reoperation with one or more internal mammary artery grafts either alone or in combination with saphenous vein grafts. The main indication for reoperation was graft closure or progression of coronary atherosclerosis in nongrafted vessels, or both. Graft construction was performed under normothermic perfusion and anoxic arrest with interrupted suture technique. No intraoperative infarctions or hospital deaths occurred...
May 1976: American Journal of Cardiology
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