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anthriscus sylvestris

Seul Ah Lee, Sung-Min Moon, Seul Hee Han, Eun Ju Hwang, Bo-Ram Park, Jae-Sung Kim, Do Kyung Kim, Chun Sung Kim
Osteoarthritis (OA) is a common degenerative joint disease, characterized by cartilage degradation and inflammation, in the elderly population. Anthriscus sylvestris has been used in Korean traditional medicine and contains many polyphenolic compounds such as cynaroside and chlorogenic acid, which are major active components responsible for its antioxidant effect. In this study, we aimed to evaluate the chondroprotective effect of an aqueous extract of A. sylvestris leaves (AE-ASL) on OA, both in vitro and in vivo...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Bo-Ram Park, Seul Ah Lee, Sung Min Moon, Chun Sung Kim
Anthricin (deoxypodophyllotoxin) is a major lignan in Anthriscus sylvestris and possesses many bioactivities such as antiproliferative, antitumor, anti‑platelet aggregation, antiviral and anti‑inflammatory actions. However, the anticancer effects of anthricin on A549 human non‑small cell lung cancer cells and potential molecular mechanisms remain unknown. Therefore, we investigated the anticancer effect of anthricin and the underlying mechanism in A549 cells. Anthricin (10‑200 nM) inhibited the viability of A549 cells in a dose‑ and time‑dependent manner...
June 2018: Oncology Reports
Minna L Haapalainen, Jinhui Wang, Satu Latvala, Mikko T Lehtonen, Minna Pirhonen, Anne I Nissinen
'Candidatus Liberibacter solanacearum' (CLso) haplotype C is associated with disease in carrots and transmitted by the carrot psyllid Trioza apicalis. To identify possible other sources and vectors of this pathogen in Finland, samples were taken of wild plants within and near the carrot fields, the psyllids feeding on these plants, parsnips growing next to carrots, and carrot seeds. For analyzing the genotype of the CLso positive samples, a multi-locus sequence typing (MLST) scheme was developed. CLso haplotype C was detected in 11% of the Trioza anthrisci samples, in 35% of the Anthriscus sylvestris plants with discoloration, and in parsnips showing leaf discoloration...
March 30, 2018: Phytopathology
Seul Ah Lee, Sung-Min Moon, Seul Hee Han, Eun Ju Hwang, Joon Ho Hong, Bo-Ram Park, Mi Suk Choi, Hoon Ahn, Jae-Sung Kim, Heung-Joong Kim, Hong Sung Chun, Do Kyung Kim, Chun Sung Kim
Anthriscus sylvestris (L.) Hoffm. is a common perennial herb that is widely distributed in Europe, Korea, and New Zealand. The root of A. sylvestris has been used in Korean traditional medicine as an antitussive and cough remedy. However, the physiologically active function of A. sylvestris leaves is not yet known. In this study, we evaluated the anti-inflammatory effects, as well as the underlying molecular mechanisms of an aqueous extract of A. sylvestris leaves (AE-ASL) in vitro and in vivo. Our results indicated that pretreatment with AE-ASL significantly inhibited the lipopolysaccharide (LPS)-induced secretion of nitric oxide (NO) and prostaglandin E2 in RAW264...
January 29, 2018: Journal of Medicinal Food
Sang-Hun Kim, Kwang-Youn Kim, Sul-Gi Park, Sun-Nyoung Yu, Young-Wook Kim, Hyo-Won Nam, Hyun-Hee An, Young-Woo Kim, Soon-Cheol Ahn
Deoxypodophyllotoxin (DPT) is a naturally occurring flavolignan isolated from Anthriscus sylvestris . Recently, it has been reported that DPT inhibits tubulin polymerization and induces G2/M cell cycle arrest followed by apoptosis through multiple cellular processes. Despite these findings, details regarding the cellular and molecular mechanisms underlying the DPT-mediated cell death have been poorly understood. To define a mechanism of DPT-mediated cell death response, we examined whether DPT activates signaling pathways for autophagy and apoptosis...
December 19, 2017: Oncotarget
Yurong Wang, Bin Wang, Mounia Guerram, Li Sun, Wei Shi, Chongchong Tian, Xiong Zhu, Zhenzhou Jiang, Luyong Zhang
Angiogenesis plays a critical role in the growth and metastasis of tumors, which makes it an attractive target for anti-tumor drug development. Deoxypodophyllotoxin (DPT), a natural product isolated from Anthriscus sylvestris, inhibits cell proliferation and migration in various cancer cell types. Our previous studies indicate that DPT possesses both anti-angiogenic and vascular-disrupting activities. Although the RhoA/ RhoA kinase (ROCK) signaling pathway is implicated in DPT-stimulated cytoskeleton remodeling and tumor vasculature suppressing, the detailed mechanisms by which DPT mediates these effects are poorly understood...
October 6, 2015: Oncotarget
Octavian Tudorel Olaru, George Mihai Niţulescu, Alina Orțan, Cristina Elena Dinu-Pîrvu
Anthriscus sylvestris (L.) Hoffm. is a wild herbaceous plant common in most temperate regions. It has been used traditionally to treat headaches, as a tonic, as antitussive, antipyretic, analgesic and diuretic. The plant contains deoxypodophyllotoxin, which is proven to have antitumor and anti-proliferative effects, anti-platelet aggregation, antiviral, anti-inflammatory and insecticidal activity. Deoxypodophyllotoxin is considered to be the plant's most important constituent, because of its pharmacological properties and because it can be converted into epipodophyllotoxin, the main raw material for the semisynthesis of the cytostatic agents etoposide and teniposide...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yu-Rong Wang, Yuan Xu, Zhen-Zhou Jiang, Mounia Guerram, Bin Wang, Xiong Zhu, Lu-Yong Zhang
Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer effect. However, the in vivo antitumor efficacy of DPT is currently indeterminate. In this study, we investigated the anti-gastric cancer effects of DPT both in vitro and in vivo. Our data showed that DPT inhibited cancer cell proliferation and induced G2/M cell cycle arrest accompanied by an increase in apoptotic cell death in SGC-7901 cancer cells. In addition, DPT caused cyclin B1, Cdc2 and Cdc25C to accumulate, decreased the expression of Bcl-2 and activated caspase-3 and PARP, suggesting that caspase-mediated pathways were involved in DPT-induced apoptosis...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Hui Chen, He-Zhong Jiang, Yong-Chao Li, Guo-Qing Wei, Yun Geng, Chao-Ying Ma
Bioassay-guided chemical investigation of the roots of Anthriscus sylvestris (L.) Hoffm. resulted in the isolation of nine compounds, whose structures were determined by spectroscopic methods. Compound 1 was isolated from this plant for the first time and compounds 3 and 9 were first found from this genus. Different polar fractions of A. sylvestris extract and compounds 1, 6-8 and 9 were evaluated for antitumor activities against HepG2 (human hepatocellular carcinoma), MG-63 (human osteosarcoma cells), B16 (melanoma cells) and HeLa (human cervical carcinoma cells) lines by the MTT method...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Chang Hwa Jung, Heemun Kim, Jiyun Ahn, Sung Keun Jung, Min Young Um, Kun-Ho Son, Tae Wan Kim, Tae Youl Ha
Anthricin (deoxypodophyllotoxin) is a natural product isolated from Anthriscus sylvestris (L.) Hoffm. (Apiaceae). Here, we investigated the effect of anthricin on autophagy and mammalian target of rapamycin (mTOR) signaling as anticancer actions in breast cancer cells. Many studies have supported the contention that the phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway is considerably deregulated in breast cancer and that autophagy plays important roles in the development of this type of cancer, although the exact underlying mechanisms remain unknown...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
Oktavia Hendrawati, Jacques Hille, Herman J Woerdenbag, Wim J Quax, Oliver Kayser
Anthriscus sylvestris (L.) Hoffm. (Apiaceae) is a common wild plant that accumulates the lignan deoxypodophyllotoxin. Deoxypodophyllotoxin can be hydroxylated at the C-7 position in recombinant organisms yielding podophyllotoxin, which is used as a semi-synthetic precursor for the anticancer drugs, etoposide phosphate and teniposide. As in vitro regeneration of A. sylvestris has not yet been reported, development of a regeneration protocol for A. sylvestris would be useful as a micropropagation tool and for metabolic engineering of the plant...
June 2012: In Vitro Cellular & Developmental Biology. Plant: Journal of the Tissue Culture Association
Qiu-e Wan, Han-ping Liu, He-ming Zhang, Song-hao Liu
The objective of the present study is to identify Ginseng and its false sample: Anthriscus sylvestris, Radix glehniae and balloonflower root by Laser Raman spectroscopy, second derivative Raman spectroscopy. The structural information of the samples indicated that Ginseng and its false samples contains a large amount of carbohydrates, since some characteristic vibration peaks of the carbohydrates, such 1 640, 1 432, 1 130, 1 086, 942, 483 cm(-'1) can be observed. The characteristic vibration peak of Radix glehniae which arouse at 2 206 cm(-1) in the aman spectra, totally different from the other three kinds of traditional Chinese medicines...
April 2012: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
Maike Kramer, Andrea Mühleis, Jürgen Conrad, Martin Leitenberger, Uwe Beifuss, Reinhold Carle, Dietmar R Kammerer
Polyacetylenes are known for their biofunctional properties in a wide range of organisms. In the present study, the most frequently occurring polyacetylenes, i.e. falcarinol, falcarindiol, and falcarindiol-3-acetate, were determined in six genera of the Apiaceae family. For this purpose, a straightforward and reliable method for the screening and quantification of the polyacetylenes using high-performance liquid chromatography coupled with diode array and mass spectrometric detection without tedious sample clean-up has been developed...
July 2011: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Oktavia Hendrawati, Herman J Woerdenbag, Paul J A Michiels, Herald G Aantjes, Annie van Dam, Oliver Kayser
The aryltetralin lignan deoxypodophyllotoxin is much more widespread in the plant kingdom than podophyllotoxin. The latter serves as a starting compound for the production of cytostatic drugs like etoposide. A better insight into the occurrence of deoxypodophyllotoxin combined with detailed knowledge of its biosynthestic pathway(s) may help to develop alternative sources for podophyllotoxin. Using HPLC combined with electrospray tandem mass spectrometry and NMR spectroscopy techniques, we found nine lignans and five related structures in roots of Anthriscus sylvestris (L...
December 2011: Phytochemistry
Oktavia Hendrawati, Herman J Woerdenbag, Jacques Hille, Wim J Quax, Oliver Kayser
Deoxypodophyllotoxin (DPT) is the main lignan in Anthriscus sylvestris . For this study two sets of experiments with 16 plants and seeds, collected from a wide geographical range, were carried out. The DPT content in roots was significantly lower (p < 0.05) when the plants were cultivated in a non-native environment. For field-grown plants the highest DPT content was found in March (second year): 0.15% w/w (dry weight) in roots; 0.03% w/w in aerial parts. For plants grown in the climate room, the highest concentration (0...
August 10, 2011: Journal of Agricultural and Food Chemistry
Yeonjoong Yong, Soon Young Shin, Young Han Lee, Yoongho Lim
An active compound having antitumor activity was isolated from the root of Anthriscus sylvestris. Structural studies revealed that it was deoxypodophyllotoxin (DPPT), and its biological activity was evaluated in HeLa human cervix carcinoma cells. Flow cytometric analysis showed that DPPT arrests the cell cycle in the G2/M phase prior to apoptosis. The mechanisms of action of DPPT involve inhibition of tubulin polymerization, dysregulation of cyclin A and cyclin B1 expression, and activation of caspases-3 and -7...
August 1, 2009: Bioorganic & Medicinal Chemistry Letters
Seok-Jong Suh, Jeong-Ran Kim, Un-Ho Jin, Hong-Seo Choi, Young-Chae Chang, Young-Choon Lee, Sung-Hoon Kim, In-Seon Lee, Tae Chul Moon, Hyeun-Wook Chang, Cheorl-Ho Kim
The matrix metalloproteinases (MMP-9 and MMP-2) in aortic smooth muscle cells (SMC) play key roles in the pathogenesis atherosclerosis. The SMC migration into the vascular wall via the bloodstream is directly linked with MMP-9 expression. Deoxypodophyllotoxin (DPT), a naturally occurring flavolignan with anti-inflammatory activity, was isolated from Anthriscus sylvestris Hoffm. and has been known inhibit the expression of MMP-9 in tumor necrosis factor-alpha (TNF-alpha) stimulated human aortic smooth muscle cells (HASMC)...
July 2009: Vascular Pharmacology
Meihua Jin, Tae Chul Moon, Zhejiu Quan, Eunkyung Lee, Yun Kyung Kim, Ju Hae Yang, Seok-Jong Suh, Tae Cheon Jeong, Seung Ho Lee, Cheorl-Ho Kim, Hyeun Wook Chang
Deoxypodophyllotoxin (DPT), a naturally occurring flavolignan with anti-inflammatory activity, was isolated from Anthriscus sylvestris HOFFM., and we examined its effects on the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated, murine macrophage-like RAW264.7 cells. Western blot analysis performed with specific anti-iNOS antibodies showed that a decrease in nitric oxide (NO) was accompanied by a decrease in the iNOS protein level. To clarify the mechanistic basis for DPT's ability to inhibit iNOS induction, we examined the effect of DPT on nuclear factor (NF)-kappaB transcriptional activity and DNA binding activity...
July 2008: Biological & Pharmaceutical Bulletin
Sang Kyu Lee, In Hye Jun, Hye Hyun Yoo, Ju Hyun Kim, Young Min Seo, Mi Jeong Kang, Seung Ho Lee, Tae Cheon Jeong, Dong Hyun Kim
The in vitro metabolism of deoxypodophyllotoxin (DPT), a medicinal herbal product isolated from Anthriscus sylvestris (Apiaceae), was investigated in rats and human microsomes and human recombinant cDNA-expressed CYPs. The incubation of DPT with pooled human microsomes in the presence of NADPH generated five metabolites while its incubation with dexamethasone (Dex)-induced rat liver resulted in seven metabolites (M1-M7) with major metabolic reactions including mono-hydroxylation, O-demethylation and demethylenation...
2008: Rapid Communications in Mass Spectrometry: RCM
Gil-Saeng Jeong, Ok-Kyoung Kwon, Bo-Young Park, Sei-Ryang Oh, Kyung-Seop Ahn, Min-Jung Chang, Won Keun Oh, Jin-Cheol Kim, Byung-Sun Min, Youn-Chul Kim, Hyeong-Kyu Lee
A new lignan, sylvestrin (1), was isolated from the MeOH-soluble fraction of the roots of Anthriscus sylvestris HOFFM. (Umbelliferae), along with six lignans (2-7), three coumarins (8-10), and a polyacetylene (11). The structure of sylvestrin was determined to be 2-(3',4',5'-trimethoxybenzylidene)-3-(3'',4''-methylendioxybenzyl)-gamma-butyrolactone (1) by spectroscopic means, including 2D-NMR. The eleven compounds were assessed for their abilities to activate a caspase-3 in human promyeloid leukemic HL-60 cells...
July 2007: Biological & Pharmaceutical Bulletin
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