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anthriscus sylvestris

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https://www.readbyqxmd.com/read/26470595/deoxypodophyllotoxin-suppresses-tumor-vasculature-in-huvecs-by-promoting-cytoskeleton-remodeling-through-lkb1-ampk-dependent-rho-a-activatio
#1
Yurong Wang, Bin Wang, Mounia Guerram, Li Sun, Wei Shi, Chongchong Tian, Xiong Zhu, Zhenzhou Jiang, Luyong Zhang
Angiogenesis plays a critical role in the growth and metastasis of tumors, which makes it an attractive target for anti-tumor drug development. Deoxypodophyllotoxin (DPT), a natural product isolated from Anthriscus sylvestris, inhibits cell proliferation and migration in various cancer cell types. Our previous studies indicate that DPT possesses both anti-angiogenic and vascular-disrupting activities. Although the RhoA/ RhoA kinase (ROCK) signaling pathway is implicated in DPT-stimulated cytoskeleton remodeling and tumor vasculature suppressing, the detailed mechanisms by which DPT mediates these effects are poorly understood...
October 6, 2015: Oncotarget
https://www.readbyqxmd.com/read/26287153/ethnomedicinal-phytochemical-and-pharmacological-profile-of-anthriscus-sylvestris-as-an-alternative-source-for-anticancer-lignans
#2
REVIEW
Octavian Tudorel Olaru, George Mihai Niţulescu, Alina Orțan, Cristina Elena Dinu-Pîrvu
Anthriscus sylvestris (L.) Hoffm. is a wild herbaceous plant common in most temperate regions. It has been used traditionally to treat headaches, as a tonic, as antitussive, antipyretic, analgesic and diuretic. The plant contains deoxypodophyllotoxin, which is proven to have antitumor and anti-proliferative effects, anti-platelet aggregation, antiviral, anti-inflammatory and insecticidal activity. Deoxypodophyllotoxin is considered to be the plant's most important constituent, because of its pharmacological properties and because it can be converted into epipodophyllotoxin, the main raw material for the semisynthesis of the cytostatic agents etoposide and teniposide...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/25608854/deoxypodophyllotoxin-induces-g2-m-cell-cycle-arrest-and-apoptosis-in-sgc-7901-cells-and-inhibits-tumor-growth-in-vivo
#3
Yu-Rong Wang, Yuan Xu, Zhen-Zhou Jiang, Mounia Guerram, Bin Wang, Xiong Zhu, Lu-Yong Zhang
Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer effect. However, the in vivo antitumor efficacy of DPT is currently indeterminate. In this study, we investigated the anti-gastric cancer effects of DPT both in vitro and in vivo. Our data showed that DPT inhibited cancer cell proliferation and induced G2/M cell cycle arrest accompanied by an increase in apoptotic cell death in SGC-7901 cancer cells. In addition, DPT caused cyclin B1, Cdc2 and Cdc25C to accumulate, decreased the expression of Bcl-2 and activated caspase-3 and PARP, suggesting that caspase-mediated pathways were involved in DPT-induced apoptosis...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/24761904/antitumor-constituents-from-anthriscus-sylvestris-l-hoffm
#4
Hui Chen, He-Zhong Jiang, Yong-Chao Li, Guo-Qing Wei, Yun Geng, Chao-Ying Ma
Bioassay-guided chemical investigation of the roots of Anthriscus sylvestris (L.) Hoffm. resulted in the isolation of nine compounds, whose structures were determined by spectroscopic methods. Compound 1 was isolated from this plant for the first time and compounds 3 and 9 were first found from this genus. Different polar fractions of A. sylvestris extract and compounds 1, 6-8 and 9 were evaluated for antitumor activities against HepG2 (human hepatocellular carcinoma), MG-63 (human osteosarcoma cells), B16 (melanoma cells) and HeLa (human cervical carcinoma cells) lines by the MTT method...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/23818925/anthricin-isolated-from-anthriscus-sylvestris-l-hoffm-inhibits-the-growth-of-breast-cancer-cells-by-inhibiting-akt-mtor-signaling-and-its-apoptotic-effects-are-enhanced-by-autophagy-inhibition
#5
Chang Hwa Jung, Heemun Kim, Jiyun Ahn, Sung Keun Jung, Min Young Um, Kun-Ho Son, Tae Wan Kim, Tae Youl Ha
Anthricin (deoxypodophyllotoxin) is a natural product isolated from Anthriscus sylvestris (L.) Hoffm. (Apiaceae). Here, we investigated the effect of anthricin on autophagy and mammalian target of rapamycin (mTOR) signaling as anticancer actions in breast cancer cells. Many studies have supported the contention that the phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway is considerably deregulated in breast cancer and that autophagy plays important roles in the development of this type of cancer, although the exact underlying mechanisms remain unknown...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/22719203/in-vitro-regeneration-of-wild-chervil-anthriscus-sylvestris-l
#6
Oktavia Hendrawati, Jacques Hille, Herman J Woerdenbag, Wim J Quax, Oliver Kayser
Anthriscus sylvestris (L.) Hoffm. (Apiaceae) is a common wild plant that accumulates the lignan deoxypodophyllotoxin. Deoxypodophyllotoxin can be hydroxylated at the C-7 position in recombinant organisms yielding podophyllotoxin, which is used as a semi-synthetic precursor for the anticancer drugs, etoposide phosphate and teniposide. As in vitro regeneration of A. sylvestris has not yet been reported, development of a regeneration protocol for A. sylvestris would be useful as a micropropagation tool and for metabolic engineering of the plant...
June 2012: In Vitro Cellular & Developmental Biology. Plant: Journal of the Tissue Culture Association
https://www.readbyqxmd.com/read/22715769/-identification-of-ginseng-and-its-counterfeit-by-laser-raman-spectroscopy
#7
Qiu-e Wan, Han-ping Liu, He-ming Zhang, Song-hao Liu
The objective of the present study is to identify Ginseng and its false sample: Anthriscus sylvestris, Radix glehniae and balloonflower root by Laser Raman spectroscopy, second derivative Raman spectroscopy. The structural information of the samples indicated that Ginseng and its false samples contains a large amount of carbohydrates, since some characteristic vibration peaks of the carbohydrates, such 1 640, 1 432, 1 130, 1 086, 942, 483 cm(-'1) can be observed. The characteristic vibration peak of Radix glehniae which arouse at 2 206 cm(-1) in the aman spectra, totally different from the other three kinds of traditional Chinese medicines...
April 2012: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
https://www.readbyqxmd.com/read/21950154/quantification-of-polyacetylenes-in-apiaceous-plants-by-high-performance-liquid-chromatography-coupled-with-diode-array-detection
#8
Maike Kramer, Andrea Mühleis, Jürgen Conrad, Martin Leitenberger, Uwe Beifuss, Reinhold Carle, Dietmar R Kammerer
Polyacetylenes are known for their biofunctional properties in a wide range of organisms. In the present study, the most frequently occurring polyacetylenes, i.e. falcarinol, falcarindiol, and falcarindiol-3-acetate, were determined in six genera of the Apiaceae family. For this purpose, a straightforward and reliable method for the screening and quantification of the polyacetylenes using high-performance liquid chromatography coupled with diode array and mass spectrometric detection without tedious sample clean-up has been developed...
July 2011: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/21889175/identification-of-lignans-and-related-compounds-in-anthriscus-sylvestris-by-lc-esi-ms-ms-and-lc-spe-nmr
#9
Oktavia Hendrawati, Herman J Woerdenbag, Paul J A Michiels, Herald G Aantjes, Annie van Dam, Oliver Kayser
The aryltetralin lignan deoxypodophyllotoxin is much more widespread in the plant kingdom than podophyllotoxin. The latter serves as a starting compound for the production of cytostatic drugs like etoposide. A better insight into the occurrence of deoxypodophyllotoxin combined with detailed knowledge of its biosynthestic pathway(s) may help to develop alternative sources for podophyllotoxin. Using HPLC combined with electrospray tandem mass spectrometry and NMR spectroscopy techniques, we found nine lignans and five related structures in roots of Anthriscus sylvestris (L...
December 2011: Phytochemistry
https://www.readbyqxmd.com/read/21604818/seasonal-variations-in-the-deoxypodophyllotoxin-content-and-yield-of-anthriscus-sylvestris-l-hoffm-grown-in-the-field-and-under-controlled-conditions
#10
Oktavia Hendrawati, Herman J Woerdenbag, Jacques Hille, Wim J Quax, Oliver Kayser
Deoxypodophyllotoxin (DPT) is the main lignan in Anthriscus sylvestris . For this study two sets of experiments with 16 plants and seeds, collected from a wide geographical range, were carried out. The DPT content in roots was significantly lower (p < 0.05) when the plants were cultivated in a non-native environment. For field-grown plants the highest DPT content was found in March (second year): 0.15% w/w (dry weight) in roots; 0.03% w/w in aerial parts. For plants grown in the climate room, the highest concentration (0...
August 10, 2011: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/19501508/antitumor-activity-of-deoxypodophyllotoxin-isolated-from-anthriscus-sylvestris-induction-of-g2-m-cell-cycle-arrest-and-caspase-dependent-apoptosis
#11
Yeonjoong Yong, Soon Young Shin, Young Han Lee, Yoongho Lim
An active compound having antitumor activity was isolated from the root of Anthriscus sylvestris. Structural studies revealed that it was deoxypodophyllotoxin (DPPT), and its biological activity was evaluated in HeLa human cervix carcinoma cells. Flow cytometric analysis showed that DPPT arrests the cell cycle in the G2/M phase prior to apoptosis. The mechanisms of action of DPPT involve inhibition of tubulin polymerization, dysregulation of cyclin A and cyclin B1 expression, and activation of caspases-3 and -7...
August 1, 2009: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/19013539/deoxypodophyllotoxin-flavolignan-from-anthriscus-sylvestris-hoffm-inhibits-migration-and-mmp-9-via-mapk-pathways-in-tnf-alpha-induced-hasmc
#12
COMPARATIVE STUDY
Seok-Jong Suh, Jeong-Ran Kim, Un-Ho Jin, Hong-Seo Choi, Young-Chae Chang, Young-Choon Lee, Sung-Hoon Kim, In-Seon Lee, Tae Chul Moon, Hyeun-Wook Chang, Cheorl-Ho Kim
The matrix metalloproteinases (MMP-9 and MMP-2) in aortic smooth muscle cells (SMC) play key roles in the pathogenesis atherosclerosis. The SMC migration into the vascular wall via the bloodstream is directly linked with MMP-9 expression. Deoxypodophyllotoxin (DPT), a naturally occurring flavolignan with anti-inflammatory activity, was isolated from Anthriscus sylvestris Hoffm. and has been known inhibit the expression of MMP-9 in tumor necrosis factor-alpha (TNF-alpha) stimulated human aortic smooth muscle cells (HASMC)...
July 2009: Vascular Pharmacology
https://www.readbyqxmd.com/read/18591766/the-naturally-occurring-flavolignan-deoxypodophyllotoxin-inhibits-lipopolysaccharide-induced-inos-expression-through-the-nf-kappab-activation-in-raw264-7-macrophage-cells
#13
Meihua Jin, Tae Chul Moon, Zhejiu Quan, Eunkyung Lee, Yun Kyung Kim, Ju Hae Yang, Seok-Jong Suh, Tae Cheon Jeong, Seung Ho Lee, Cheorl-Ho Kim, Hyeun Wook Chang
Deoxypodophyllotoxin (DPT), a naturally occurring flavolignan with anti-inflammatory activity, was isolated from Anthriscus sylvestris HOFFM., and we examined its effects on the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated, murine macrophage-like RAW264.7 cells. Western blot analysis performed with specific anti-iNOS antibodies showed that a decrease in nitric oxide (NO) was accompanied by a decrease in the iNOS protein level. To clarify the mechanistic basis for DPT's ability to inhibit iNOS induction, we examined the effect of DPT on nuclear factor (NF)-kappaB transcriptional activity and DNA binding activity...
July 2008: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/18050240/characterization-of-in-vitro-metabolites-of-deoxypodophyllotoxin-in-human-and-rat-liver-microsomes-using-liquid-chromatography-tandem-mass-spectrometry
#14
Sang Kyu Lee, In Hye Jun, Hye Hyun Yoo, Ju Hyun Kim, Young Min Seo, Mi Jeong Kang, Seung Ho Lee, Tae Cheon Jeong, Dong Hyun Kim
The in vitro metabolism of deoxypodophyllotoxin (DPT), a medicinal herbal product isolated from Anthriscus sylvestris (Apiaceae), was investigated in rats and human microsomes and human recombinant cDNA-expressed CYPs. The incubation of DPT with pooled human microsomes in the presence of NADPH generated five metabolites while its incubation with dexamethasone (Dex)-induced rat liver resulted in seven metabolites (M1-M7) with major metabolic reactions including mono-hydroxylation, O-demethylation and demethylenation...
2008: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/17603178/lignans-and-coumarins-from-the-roots-of-anthriscus-sylvestris-and-their-increase-of-caspase-3-activity-in-hl-60-cells
#15
Gil-Saeng Jeong, Ok-Kyoung Kwon, Bo-Young Park, Sei-Ryang Oh, Kyung-Seop Ahn, Min-Jung Chang, Won Keun Oh, Jin-Cheol Kim, Byung-Sun Min, Youn-Chul Kim, Hyeong-Kyu Lee
A new lignan, sylvestrin (1), was isolated from the MeOH-soluble fraction of the roots of Anthriscus sylvestris HOFFM. (Umbelliferae), along with six lignans (2-7), three coumarins (8-10), and a polyacetylene (11). The structure of sylvestrin was determined to be 2-(3',4',5'-trimethoxybenzylidene)-3-(3'',4''-methylendioxybenzyl)-gamma-butyrolactone (1) by spectroscopic means, including 2D-NMR. The eleven compounds were assessed for their abilities to activate a caspase-3 in human promyeloid leukemic HL-60 cells...
July 2007: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/17137110/deoxypodophyllotoxin-content-and-antioxidant-activity-of-aerial-parts-of-anthriscus-sylvestris-hoffm
#16
Stefano Dall'Acqua, Michela Giorgetti, Rinaldo Cervellati, Gabbriella Innocenti
Deoxypodophyllotoxin content of the aerial parts of Anthriscus sylvestris Hoffm. growing at different altitudes was evaluated in comparison to the roots. The lignan accumulation in ground parts was at least double compared to aerial ones. In addition antioxidant-guided fractionation of the crude methanol extract of aerial parts was performed with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. Active fractions contained mainly luteolin-7-O-glucoside and chlorogenic acid. Antioxidant properties of both crude extract and isolated compounds were also investigated with the Briggs-Rauscher (BR) oscillating reaction...
September 2006: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/16732515/deoxypodophyllotoxin-dpt-inhibits-eosinophil-recruitment-into-the-airway-and-th2-cytokine-expression-in-an-ova-induced-lung-inflammation
#17
Chang Xin Lin, Eunkyung Lee, Mei Hua Jin, Jumin Yook, Zhejiu Quan, Kyungmi Ha, Tae Chul Moon, Mi Jin Kim, Keuk Jun Kim, Seung Ho Lee, Hyeun Wook Chang
The effect of deoxypodophyllotoxin (DPT) isolated from Anthriscus sylvestris Hoffm. was evaluated in an IN VIVO animal model for antiasthmatic activity. DPT (1.0 to 5 mg/kg) was given orally to ovalbumin (OVA)/alum-induced asthmatic mice. DPT reduced the number of infiltrated eosinophils in bronchoalveolar lavage (BAL) fluid in a dose-dependent manner. Dexamethasone (5 mg/kg), which was used as a positive control, also strongly inhibited the number of infiltrated eosinophils. The effect of DPT on a transcript profile in a murine asthma model was determined by RT-PCR, which showed that DPT decreased the mRNA levels of the Th2 cytokines...
July 2006: Planta Medica
https://www.readbyqxmd.com/read/15187418/dual-inhibition-of-cyclooxygenases-2-and-5-lipoxygenase-by-deoxypodophyllotoxin-in-mouse-bone-marrow-derived-mast-cells
#18
Seung Ho Lee, Min Jung Son, Hye Kyung Ju, Chang Xiu Lin, Tae Chul Moon, Han-Gon Choi, Jong Keun Son, Hyeun Wook Chang
Deoxypodophyllotoxin (Anthricin) is a medicinal herbal product isolated from Anthriscus sylvestris HOFFM. that inhibits cyclooxygenase-2 (COX-2) and COX-1-dependent phases of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC(50) values of 1.89 microM and 65.3 microM, respectively. This study also found that this compound inhibited COX-1 and 2-dependent conversion of the exogenous arachidonic acid to PGD(2) in a dose-dependent manner with an IC(50) values of 0...
June 2004: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/15124098/deoxypodophyllotoxin-a-naturally-occurring-lignan-inhibits-the-passive-cutaneous-anaphylaxis-reaction
#19
Chang Xiu Lin, Min Jung Son, Hye Kyung Ju, Tae Chul Moon, Eunkyung Lee, So Hee Kim, Mi-Jeong Kim, Jong Keun Son, Seung Ho Lee, Hyeun Wook Chang
This study examined the effect of a podophyllotoxin derivative, deoxypodophyllotoxin (anthricin), which is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. Deoxypodophyllotoxin was tested in a rat PCA (passive cutaneous anaphylaxis) assay by administering deoxypodophyllotoxin intraperitoneally (1.0 to 10 mg/kg, i.p.) and intravenously (0.25 to 1.0 mg/kg, i.v.). Deoxypodophyllotoxin dose-dependently inhibited the PCA reaction activated by anti-dinitrophenyl (DNP) IgE. The PCA inhibitory activity of deoxypodophyllotoxin was stronger than those of prednisolone and indomethacin, which were used as positive controls...
May 2004: Planta Medica
https://www.readbyqxmd.com/read/15101098/comparative-studies-on-phenotypic-plasticity-of-two-herbs-changium-smyrnioides-and-anthriscus-sylvestris
#20
COMPARATIVE STUDY
Jie Chang, Bao-hua Guan, Ying Ge, Yuk-sing Gilbert Chan
The endangered medicinal herb, Changium smyrnioides can only be found in deciduous forest gaps within the middle to northern subtropical broad-leaved evergreen forest zone of China. The considerable plasticity of its shoot and root structure helps it to capture light more effectively in winter and early spring, and to adapt to the soil moisture conditions in its narrow habitat. Another medicinal plant, Anthriscus sylvestris, is of similar economic importance but commonly dis-tributed widely. In contrast to C...
June 2004: Journal of Zhejiang University. Science
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