keyword
MENU ▼
Read by QxMD icon Read
search

two photon

keyword
https://www.readbyqxmd.com/read/29166603/caveolin1-is-required-for-th1-cell-infiltration-but-not-tight-junction-remodeling-at-the-blood-brain-barrier-in-autoimmune-neuroinflammation
#1
Sarah E Lutz, Julian R Smith, Dae Hwan Kim, Carl V L Olson, Kyle Ellefsen, Jennifer M Bates, Sunil P Gandhi, Dritan Agalliu
Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly understood. We have used intravital two-photon imaging of the spinal cord in wild-type and caveolae-deficient mice with fluorescently labeled endothelial tight junctions to determine how tight junction remodeling and caveolae regulate CNS entry of lymphocytes during the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166599/maturation-of-cerebellar-purkinje-cell-population-activity-during-postnatal-refinement-of-climbing-fiber-network
#2
Jean-Marc Good, Michael Mahoney, Taisuke Miyazaki, Kenji F Tanaka, Kenji Sakimura, Masahiko Watanabe, Kazuo Kitamura, Masanobu Kano
Neural circuits undergo massive refinements during postnatal development. In the developing cerebellum, the climbing fiber (CF) to Purkinje cell (PC) network is drastically reshaped by eliminating early-formed redundant CF to PC synapses. To investigate the impact of CF network refinement on PC population activity during postnatal development, we monitored spontaneous CF responses in neighboring PCs and the activity of populations of nearby CF terminals using in vivo two-photon calcium imaging. Population activity is highly synchronized in newborn mice, and the degree of synchrony gradually declines during the first postnatal week in PCs and, to a lesser extent, in CF terminals...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166077/low-energy-photoelectron-transmission-through-aerosol-overlayers
#3
Stavros Amanatidis, Bruce L Yoder, Ruth Signorell
The transmission of low-energy (<1.8 eV) photoelectrons through the shell of core-shell aerosol particles is studied for liquid squalane, squalene, and di-ethyl-hexyl-sebacate shells. The photoelectrons are exclusively formed in the core of the particles by two-photon ionization. The total photoelectron yield recorded as a function of shell thicknesses (1-80 nm) shows a bi-exponential attenuation. For all substances, the damping parameter for shell thicknesses below 15 nm lies around 8 to 9 nm and is tentatively assigned to the electron attenuation length at electron kinetic energies of ≲1 eV...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166070/effect-of-the-diradical-character-on-static-polarizabilities-and-two-photon-absorption-cross-sections-a-closer-look-with-spin-flip-equation-of-motion-coupled-cluster-singles-and-doubles-method
#4
Kaushik D Nanda, Anna I Krylov
We present static polarizabilities and two-photon absorption (2PA) cross sections for the low-lying electronic states of prototypical diradicals such as benzynes and analogues of m-xylylene and p-quinodimethane computed with the spin-flip equation-of-motion coupled-cluster singles and doubles (EOM-SF-CCSD) method. The static polarizabilities were calculated as analytic second derivatives of the EOM energies, and the 2PA cross sections were calculated using the expectation-value approach. We explain the trends in the nonlinear responses of the SF target states by constructing few-states models based on truncated sum-over-states expressions for these nonlinear properties...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166019/femtosecond-raman-microscopy-reveals-structural-dynamics-leading-to-triplet-separation-in-rubrene-singlet-fission
#5
Kajari Bera, Christopher J Douglas, Renee R Frontiera
Singlet fission generates multiple excitons from a single photon, which in theory can result in solar cell efficiencies with values above the Shockley-Queisser limit. Understanding the molecular structural dynamics during singlet fission will help to fabricate efficient organic photovoltaic devices. Here we use femtosecond stimulated Raman spectroscopy to reveal the structural evolution during the triplet separation in rubrene. We observe vibrational signatures of the correlated triplet pair, as well as shifting of the vibrational frequencies of the 1430 and 1542 cm(-1) excited state modes, which increase by more than 25 cm(-1) in 5 ps...
November 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29166017/bond-dissociation-energies-of-tungsten-molecules-wc-wsi-ws-wse-and-wcl
#6
Andrew Sevy, Robert F Huffaker, Michael D Morse
Resonant two-photon ionization spectroscopy has been used to locate predissociation thresholds in WC, WSi, WS, WSe, and WCl, allowing bond dissociation energies to be measured for these species. Because of the high degree of vibronic congestion in the observed spectra, it is thought that the molecules dissociate as soon as the lowest separated atom limit is exceeded. From the observed predissociation thresholds, dissociation energies are assigned as D0(WC) = 5.289(8) eV, D0(WSi) = 3.103(10) eV, D0(WS) = 4.935(3) eV, D0(WSe) = 4...
November 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29165980/controlled-insertion-of-planar-defect-in-inverse-opals-for-anti-counterfeiting-applications
#7
Yongjoon Heo, Su Yeon Lee, Ji-Won Kim, Tae Yoon Jeon, Shin-Hyun Kim
Inverse opals have been used for structural coloration and photonic applications owing to their photonic bandgap properties. When the photonic structures contain planar defects, they provide defect modes, which are useful for lasing, sensing, and waveguiding. However, it remains a challenge to insert a planar defect into inverse opals in a reproducible manner. Here, we report a new method for producing planar-defect-inserted inverse opals using sequential capillary wetting of colloidal crystals and creating micropatterns through photolithography...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29165917/a-novel-multisite-confocal-system-for-rapid-ca-2-imaging-from-submicron-structures-in-brain-slices
#8
Luiza Filipis, Karima Ait Ouares, Philippe Moreau, Dimitrii Tanese, Valeria Zampini, Andrea Latini, Chun Bleau, Charlie Bleau, Jeremy Graham, Marco Canepari
In brain slices, resolving fast Ca(2+) fluorescence signals from submicron structures is typically achieved using two-photon or confocal scanning microscopy, an approach that limits the number of scanned points. The novel multiplexing confocal system presented here overcomes this limitation. This system is based on a fast spinning disk, a multimode diode laser and a novel high-resolution CMOS camera. The spinning disk, running at 20,000 rpm, has custom-designed spiral pattern that maximises light collection while rejecting out-of-focus fluorescence to resolve signals from small neuronal compartments...
November 22, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29165568/second-harmonic-generation-reveals-subtle-fibrosis-differences-in-adult-and-pediatric-nonalcoholic-fatty-liver-disease
#9
Feng Liu, Jing-Min Zhao, Hui-Ying Rao, Wei-Miao Yu, Wei Zhang, Neil D Theise, Aileen Wee, Lai Wei
Objectives: Investigate subtle fibrosis similarities and differences in adult and pediatric nonalcoholic fatty liver disease (NAFLD) using second harmonic generation (SHG). Methods: SHG/two-photon excitation fluorescence imaging quantified 100 collagen parameters and determined qFibrosis values by using the nonalcoholic steatohepatitis (NASH) Clinical Research Network (CRN) scoring system in 62 adult and 36 pediatric NAFLD liver specimens. Results: Six distinct parameters identified differences among the NASH CRN stages with high accuracy (area under the curve, 0835-0...
November 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29164879/efficient-singlet-fission-and-triplet-pair-emission-in-a-family-of-zethrene-diradicaloids
#10
Steven Lukman, Johannes M Richter, Le Yang, Pan Hu, Jishan Wu, Neil C Greenham, Andrew J Musser
Singlet fission offers the potential to overcome thermodynamic limits in solar cells by converting the energy of a single absorbed photon into two distinct triplet excitons. However, progress is limited by the small family of suitable materials, and new chromophore design principles are needed. Here, we experimentally vindicate the design concept of diradical stabilisation, in a tuneable family of functionalised zethrenes. All molecules in the series exhibit rapid formation of a bound, spin-entangled triplet-pair state TT...
November 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29162279/clinical-decision-support-of-radiotherapy-treatment-planning-a-data-driven-machine-learning-strategy-for-patient-specific-dosimetric-decision-making
#11
Gilmer Valdes, Charles B Simone, Josephine Chen, Alexander Lin, Sue S Yom, Adam J Pattison, Colin M Carpenter, Timothy D Solberg
BACKGROUND AND PURPOSE: Clinical decision support systems are a growing class of tools with the potential to impact healthcare. This study investigates the construction of a decision support system through which clinicians can efficiently identify which previously approved historical treatment plans are achievable for a new patient to aid in selection of therapy. MATERIAL AND METHODS: Treatment data were collected for early-stage lung and postoperative oropharyngeal cancers treated using photon (lung and head and neck) and proton (head and neck) radiotherapy...
November 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29160321/uv-photodissociation-dynamics-of-chi2cl-and-its-role-as-a-photolytic-precursor-for-a-chlorinated-criegee-intermediate
#12
Kara M Kapnas, Benjamin W Toulson, Elizabeth S Foreman, Sarah A Block, J Grant Hill, Craig Murray
Photolysis of geminal diiodoalkanes in the presence of molecular oxygen has become an established route to the laboratory production of several Criegee intermediates, and such compounds also have marine sources. Here, we explore the role that the trihaloalkane, chlorodiiodomethane (CHI2Cl), may play as a photolytic precursor for the chlorinated Criegee intermediate ClCHOO. CHI2Cl has been synthesized and its UV absorption spectrum measured; relative to that of CH2I2 the spectrum is shifted to longer wavelength and the photolysis lifetime is calculated to be less than two minutes...
November 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29159881/characterization-of-photon-counting-multi-slit-breast-tomosynthesis
#13
Karl Berggren, Björn Cederström, Mats Lundqvist, Erik Fredenberg
PURPOSE: It has been shown that breast tomosynthesis may improve sensitivity and specificity compared to 2D mammography, resulting in increased detection-rate of cancers or lowered call-back rates. The purpose of this study is to characterize a spectral photon-counting multi-slit breast tomosynthesis system that is able to do single-scan spectral imaging with multiple collimated x-ray beams. The system differs in many aspects compared to conventional tomosynthesis using energy-integrating flat-panel detectors...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159356/influence-of-the-anatase-rutile-ratio-on-the-charge-transport-properties-of-tio2-nts-arrays-studied-by-dual-wavelength-opto-electrochemical-impedance-spectroscopy
#14
T Cottineau, H Cachet, V Keller, E M M Sutter
The modification of photo-generated charge transport properties in aligned titanium dioxide nanotubes (TiO2-NTs) regarding the anatase/rutile ratio was studied by photo-electrochemical methods. TiO2-NTs obtained by anodization were thermally treated under air flux at different temperatures to significantly modify the proportion of TiO2 anatase and rutile phases in the tubular structure. Material characterisation methods (XRD, SEM, UV-visible spectroscopy) were used to determine the characteristics of the different TiO2-NT electrodes in terms of dimensions, proportion of each phase and optical properties...
November 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29159011/proton-therapy-for-malignant-pleural-mesothelioma-a-three-case-series-describing-the-clinical-and-dosimetric-advantages-of-proton-based-therapy
#15
Howard Lee, Jing Zeng, Stephen R Bowen, Ramesh Rengan
Malignant pleural mesothelioma (MPM) is a malignancy of the pleural cavity that typically presents at an advanced stage. Due to its large, circumferential clinical target volume (CTV) and proximity to major structures, including the heart and contralateral lung, delivering hemithoracic intensity-modulated radiotherapy (IMRT) with photon therapy to achieve loco-regional control following macroscopic complete resection is challenging. Intensity-modulated proton therapy (IMPT) has been shown to be a method for achieving higher therapeutic doses while limiting exposure to organs at risk (OARs), but patient outcomes after treatment have yet to be reported...
September 20, 2017: Curēus
https://www.readbyqxmd.com/read/29159005/field-specific-intensity-modulated-proton-therapy-optimization-technique-for-breast-cancer-patients-with-tissue-expanders-containing-metal-ports
#16
Maura Kirk, Gary Freedman, Thorsten Ostrander, Lei Dong
This report aims to propose and present an evaluation of a robust pencil beam scanning proton multi-field optimized treatment planning technique for postmastectomy radiation of breast cancer patients with implanted tissue expanders containing an internal metal port. Field-specific split targets were created for optimization to prevent spots from traveling through the metal port, while providing uniform coverage of the target with the use of a multi-field intensity modulated optimization approach. Two beam angles were strategically selected to provide complementary target coverage and plan robustness...
September 18, 2017: Curēus
https://www.readbyqxmd.com/read/29158596/efficient-cross-talk-reduction-of-nanophotonic-circuits-enabled-by-fabrication-friendly-periodic-silicon-strip-arrays
#17
Yusheng Bian, Qiang Ren, Lei Kang, Yifeng Qin, Pingjuan L Werner, Douglas H Werner
Reduction of the crosstalk between adjacent photonic components has been regarded as one of the most effective, yet most challenging approaches for increasing the packing density of photonic integrated circuits. Recently, extensive efforts have been devoted to this field, leading to a number of elaborate designs, such as waveguide supperlattice and nanophotonic cloaking, among others. Here we develop a simple and efficient crosstalk reduction approach for silicon-based nanophotonic circuits by introducing a periodic array of silicon strips between adjacent waveguides...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29157265/the-impact-of-dual-energy-ct-imaging-on-dose-calculations-for-pre-clinical-studies
#18
Ana Vaniqui, Lotte E J R Schyns, Isabel P Almeida, Brent van der Heyden, Stefan J van Hoof, Frank Verhaegen
BACKGROUND: To investigate the feasibility of using dual-energy CT (DECT) for tissue segmentation and kilovolt (kV) dose calculations in pre-clinical studies and assess potential dose calculation accuracy gain. METHODS: Two phantoms and an ex-vivo mouse were scanned in a small animal irradiator with two distinct energies. Tissue segmentation was performed with the single-energy CT (SECT) and DECT methods. A number of different material maps was used. Dose calculations were performed to verify the impact of segmentations on the dose accuracy...
November 21, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29155277/neurotrophin-and-fgf-signaling-adapter-proteins-frs2-and-frs3-regulate-dentate-granule-cell-maturation-and-excitatory-synaptogenesis
#19
Sayan Nandi, Karina Alviña, Pablo J Lituma, Pablo E Castillo, Jean M Hébert
Dentate granule cells (DGCs) play important roles in cognitive processes. Knowledge about how growth factors such as FGFs and neurotrophins contribute to the maturation and synaptogenesis of DGCs is limited. Here, using brain-specific and germline mouse mutants we show that a module of neurotrophin and FGF signaling, the FGF Receptor Substrate (FRS) family of intracellular adapters, FRS2 and FRS3, are together required for postnatal brain development. In the hippocampus, FRS promotes dentate gyrus morphogenesis and DGC maturation during developmental neurogenesis, similar to previously published functions for both neurotrophins and FGFs...
November 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/29152568/moir%C3%A3-excitons-from-programmable-quantum-emitter-arrays-to-spin-orbit-coupled-artificial-lattices
#20
Hongyi Yu, Gui-Bin Liu, Jianju Tang, Xiaodong Xu, Wang Yao
Highly uniform and ordered nanodot arrays are crucial for high-performance quantum optoelectronics, including new semiconductor lasers and single-photon emitters, and for synthesizing artificial lattices of interacting quasiparticles toward quantum information processing and simulation of many-body physics. Van der Waals heterostructures of two-dimensional semiconductors are naturally endowed with an ordered nanoscale landscape, that is, the moiré pattern that laterally modulates electronic and topographic structures...
November 2017: Science Advances
keyword
keyword
4602
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"