keyword
https://read.qxmd.com/read/38492923/hepatitis-c-elimination-in-rwanda-progress-feasibility-and-economic-evaluation
#21
JOURNAL ARTICLE
Huaiyang Zhong, Alec Aaron, Lindsey Hiebert, Janvier Serumondo, Yueran Zhuo, Madeline Adee, Gallican N Rwibasira, John W Ward, Jagpreet Chhatwal
OBJECTIVE: In 2018, Rwanda launched a national program to eliminate the hepatitis C virus (HCV). We aim to assess the impact of the program to date and identify strategies to achieve the World Health Organization's HCV elimination goals by 2030. METHODS: We developed a microsimulation model to simulate Rwanda's HCV epidemic from 2015 through 2050 and evaluated temporal trends in HCV infection, prevalence, mortality, and the total cost of care for scenarios that could achieve HCV elimination by 2030...
March 14, 2024: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/38489517/accuracy-of-blood-based-biomarkers-for-staging-liver-fibrosis-in-chronic-liver-disease-a-systematic-review-supporting-the-aasld-practice-guideline
#22
JOURNAL ARTICLE
Keyur Patel, Sumeet K Asrani, Maria Isabel Fiel, Deborah Levine, Daniel H Leung, Andres Duarte-Rojo, Jonathan A Dranoff, Tarek Nayfeh, Bashar Hasan, Tamar H Taddei, Yahya Alsawaf, Samer Saadi, Abdul Mounaem Majzoub, Apostolos Manolopoulos, Muayad Alzuabi, Jingyi Ding, Nigar Sofiyeva, M Hassan Murad, Mouaz Alsawas, Don C Rockey, Richard K Sterling
BACKGROUND AND AIMS: Blood-based biomarkers have been proposed as an alternative to liver biopsy for non-invasive liver disease assessment (NILDA) in chronic liver disease (CLD). Our aims for this systematic review were to evaluate the diagnostic utility of selected blood-based tests either alone, or in combination, for identifying significant fibrosis (F2-4), advanced fibrosis (F3-4) and cirrhosis (F4), as compared to biopsy in CLD. APPROACH AND RESULTS: We included a comprehensive search of databases including Ovid MEDLINE(R), EMBASE, Cochrane Database, and Scopus through to April 2022...
March 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38487594/hepatitis-c-virus-infection-and-hospital-related-outcomes-a-systematic-review
#23
REVIEW
Michelle Ng, Patrizia Maria Carrieri, Lindila Awendila, Maria Eugenia Socías, Rod Knight, Lianping Ti
BACKGROUND: People living with hepatitis C infection (HCV) have a significant impact on the global healthcare system, with high rates of inpatient service use. Direct-acting antivirals (DAAs) have the potential to alleviate this burden; however, the evidence on the impact of HCV infection and hospital outcomes is undetermined. This systematic review aims to assess this research gap, including how DAAs may modify the relationship between HCV infection and hospital-related outcomes. METHODS: We searched five databases up to August 2022 to identify relevant studies evaluating the impact of HCV infection on hospital-related outcomes...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38486197/acceptance-and-feasibility-of-a-low-threshold-and-substitution-services-based-periodical-monitoring-system-for-blood-borne-and-sexually%C3%A2-transmitted-infections-among-people-who-inject-drugs-in-germany-a-mixed-methods-analysis
#24
JOURNAL ARTICLE
Amrei Krings, Gyde Steffen, Ruth Zimmermann
BACKGROUND: To reach the global elimination goals of viral hepatitis B and C (HBC, HCV), human immunodeficiency virus (HIV) and other sexually transmitted infections as a public health threat by 2030, monitoring is needed. Staff members of drug services and opioid substitution treatment (OST) practices in Berlin and Bavaria recruited clients for a pilot study addressing the respective infections among people who injected drugs (PWID) in Germany, 2021/2022. Participants filled a questionnaire and were tested for HBV, HCV, HIV and syphilis using dried blood spots (DBS)...
March 14, 2024: Harm Reduction Journal
https://read.qxmd.com/read/38483035/direct-acting-antivirals-in-women-of-reproductive-age-infected-with-hepatitis-c-virus
#25
JOURNAL ARTICLE
Krystyna Dobrowolska, Małgorzata Pawłowska, Dorota Zarębska-Michaluk, Piotr Rzymski, Ewa Janczewska, Magdalena Tudrujek-Zdunek, Hanna Berak, Włodzimierz Mazur, Jakub Klapaczyński, Beata Lorenc, Justyna Janocha-Litwin, Anna Parfieniuk-Kowerda, Dorota Dybowska, Anna Piekarska, Rafał Krygier, Beata Dobracka, Jerzy Jaroszewicz, Robert Flisiak
Eliminating hepatitis C virus (HCV) infection in the population of women of reproductive age is important not only for the health of women themselves but also for the health of newborns. This study aimed to evaluate the implementation of this goal by analysing the effectiveness of contemporary therapy in a large cohort from everyday clinical practice along with identifying factors reducing therapeutic success. The analysed population consisted of 7861 patients, including 3388 women aged 15-49, treated in 2015-2022 in 26 hepatology centres...
March 14, 2024: Journal of Viral Hepatitis
https://read.qxmd.com/read/38482346/-bacillus-pumilus-cellulitis-with-bacteremia-in-a-person-who-injects-drugs-living-with-hiv-hcv-co-infection-a-case-report
#26
João Neves-Maia, Maria João Ramos, Hugo Cruz, Mariana Meireles
Bacillus pumilus ( B. pumilus ) is a ubiquitous spore-forming bacteria that has rarely been implicated in extraintestinal infections, mostly in immunocompromised hosts. The authors report a case of B. pumilus cellulitis with bacteremia in a person who injects drugs living with human immunodeficiency virus-hepatitis C virus (HIV-HCV) co-infection. Although similar cases have been reported for some species of the genus, namely Bacillus anthracis ( B. anthracis ) and Bacillus cereus (B. cereus ), this case reinforces the importance of considering other Bacillus spp...
2024: Access microbiology
https://read.qxmd.com/read/38482011/carcinogenic-mechanisms-of-virus-associated-lymphoma
#27
REVIEW
Ying Zhang, Wei Guo, Zhumei Zhan, Ou Bai
The development of lymphoma is a complex multistep process that integrates numerous experimental findings and clinical data that have not yet yielded a definitive explanation. Studies of oncogenic viruses can help to deepen insight into the pathogenesis of lymphoma, and identifying associations between lymphoma and viruses that are established and unidentified should lead to cellular and pharmacologically targeted antiviral strategies for treating malignant lymphoma. This review focuses on the pathogenesis of lymphomas associated with hepatitis B and C, Epstein-Barr, and human immunodeficiency viruses as well as Kaposi sarcoma-associated herpesvirus to clarify the current status of basic information and recent advances in the development of virus-associated lymphomas...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38479437/australian-consensus-statement-on-doxycycline-post-exposure-prophylaxis-doxy-pep-for-the-prevention-of-syphilis-chlamydia-and-gonorrhoea-among-gay-bisexual-and-other-men-who-have-sex-with-men
#28
JOURNAL ARTICLE
Vincent J Cornelisse, Benjamin Riley, Nicholas A Medland
INTRODUCTION: Doxycycline post-exposure prophylaxis (doxy-PEP) involves consuming 200 mg of doxycycline up to 72 hours after a condomless sex act to reduce the risk of bacterial sexually transmitted infections (STIs). Recent clinical trials of doxy-PEP have demonstrated significant reductions in syphilis, chlamydia and, to a lesser degree, gonorrhoea among gay, bisexual and other men who have sex with men (GBMSM). There is a high level of interest in doxy-PEP in the GBMSM community and, in response, the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM) held a national consensus conference with the aim of creating preliminary guidance for clinicians, community, researchers and policy makers...
March 13, 2024: Medical Journal of Australia
https://read.qxmd.com/read/38477724/trends-in-vasectomy-and-sexually-transmitted-diseases-in-chile-findings-from-robust-national-databases
#29
JOURNAL ARTICLE
Daniela Toledo, Cinthya Urquidi, Alejandro Sepúlveda-Peñaloza, Rodrigo Leyton
A controversy about the increase or decline of vasectomy is emerging; however, the evidence is still scarce in Latin America. This ecological study analyzed the vasectomy and sexual transmitted diseases (STD) trends over a period of 10 years in Chile and determined if there is any relationship between them. We conducted a mixed ecological study using secondary and representative data on the number of vasectomies and STD cases from 2008 to 2017. Vasectomy rates were calculated for age-specific groups of men aged 20-59 years, and specific STD (HIV, chlamydia, gonorrhea, trichomoniasis, and syphilis) for the same period...
2024: Cadernos de Saúde Pública
https://read.qxmd.com/read/38477465/impact-of-human-immunodeficiency-virus-infection-on-liver-and-cardiovascular-outcomes-in-veterans-with-metabolic-dysfunction-associated-steatotic-liver-disease
#30
JOURNAL ARTICLE
Robert J Wong, Zeyuan Yang, Aaron Yeoh, Albert Do, Aijaz Ahmed, Ramsey Cheung
OBJECTIVE: Hepatic steatosis in highly prevalent in people living with human immunodeficiency virus (HIV). It remains unclear whether HIV in patients with metabolic dysfunction associated steatotic liver disease (MASLD) is associated with greater risks of liver disease progression and cardiovascular disease (CVD). We aim to evaluate the impact of HIV infection on risks of liver and CVD outcomes among U.S. Veterans with MASLD. METHODS: Using national Veterans Administration data from 2010-2022, we created a propensity score matched cohort of MASLD patients with vs...
March 13, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38472731/patterns-of-socioeconomic-marginalization-among-people-who-use-drugs-a-gender-stratified-repeated-measures-latent-class-analysis
#31
JOURNAL ARTICLE
Sanjana Mitra, Thomas Kerr, Zishan Cui, Mark Gilbert, Mathew Fleury, Kanna Hayashi, M-J Milloy, Lindsey Richardson
Socioeconomic factors are important correlates of drug use behaviors and health-related outcomes in people who use drugs (PWUD) residing in urban areas. However, less is known about the complex overlapping nature of socioeconomic conditions and their association with a range of individual, drug use, and health-related factors in men and women who use drugs. Data were obtained from two community-recruited prospective cohorts of PWUD. Using a gender-stratified approach, we conducted repeated measures latent class analyses (RMLCA) to identify discrete latent socioeconomic subgroups...
March 12, 2024: Journal of Urban Health
https://read.qxmd.com/read/38467959/sexual-health-needs-among-men-who-engage-in-transactional-sex-with-men-in-the-uk
#32
JOURNAL ARTICLE
Francesco Avallone, Ford Hickson
Men who engage in transactional sex with men (MTSM) are a high-risk population for HIV and other sexually transmitted infections. Epidemiological data have so far included them in the broad category of men who have sex with men (MSM), while research on transactional sex typically focused on female sex workers. The internet has substantially changed sex work practices and earlier findings concerning the sexual health needs of MTSM may no longer be applicable. We analyzed quantitative data from MSM based in the UK (n = 11629) taking part in the European MSM Internet Survey (EMIS-2017)...
March 11, 2024: Archives of Sexual Behavior
https://read.qxmd.com/read/38463912/prevalence-of-hiv-hbv-hcv-hpv-and-syphilis-among-female-sex-workers-in-kurdistan-west-of-iran
#33
JOURNAL ARTICLE
Somaye Mafakheri Bashmaq, Amjad Ahmadi, Behzad Mohsenpour, Khaled Rahmani, Modabber Arasteh, Narges Shams Alizadeh, Asrin Babahajian, Shoaib Advay, Asefeh Abbaszadeh
BACKGROUND: Female sex workers (FSWs) in most societies run a high risk of health problems, including sexually transmitted infections (STIs) such as viral infections and syphilis. The present study examines the prevalence of viral infections and syphilis among FSWs. METHODS: This cross-sectional study recruited 100 female sex workers (April 2019 to April 2020) who visited the Counseling Center for Behavioral Diseases or were selected via purposeful (snowball) sampling...
2024: Caspian Journal of Internal Medicine
https://read.qxmd.com/read/38462427/thiazolidinediones-are-partially-effective-bitter-blockers
#34
JOURNAL ARTICLE
Ha Nguyen, Cailu Lin, Ivona Sasimovich, Katherine Bell, Amy Huang, Emilia Leszkowicz, Nancy E Rawson, Danielle R Reed
PURPOSE: The bad bitter taste of some medicines is a barrier to overcoming noncompliance with medication use, especially life-saving drugs given to children and the elderly. Here, we evaluated a new class of bitter blockers (thiazolidinediones, TZDs). METHODS: In this study, 2 TZDs were tested, rosiglitazone (ROSI) and a simpler form of TZD, using a high-potency sweetener as a positive control (neohesperidin dihydrochalcone, NHDC). We tested bitter-blocking effects using the bitter drugs tenofovir alafenamide fumarate (TAF), a treatment for HIV and hepatitis B infection, and praziquantel (PRAZ), a treatment for schistosomiasis, by conducting taste testing with 2 separate taste panels: a general panel (N = 97, 20-23 years, 82...
March 9, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38459735/personalized-care-approaches-to-hepatitis-c-therapy-recent-advances-and-future-directions
#35
REVIEW
Nicola Schiano Moriello, Biagio Pinchera, Ivan Gentile
INTRODUCTION: The introduction of direct-acting antivirals (DAAs) has significantly transformed the therapeutic landscape for chronic C hepatitis virus (HCV) infection. However, there is still room for further improvement in optimizing therapy efficacy and minimizing adverse effects. AREAS COVERED: This review is devoted to the rationale for adopting a personalized approach to HCV therapy. Specifically, we explore the role of host-related factors, such as sex or the presence of comorbidities...
March 8, 2024: Expert Review of Anti-infective Therapy
https://read.qxmd.com/read/38457965/unmet-need-for-medication-for-opioid-use-disorder-among-persons-who-inject-drugs-in-23%C3%A2-u-s-cities
#36
JOURNAL ARTICLE
Senad Handanagic, Dita Broz, Teresa Finlayson, Dafna Kanny, Cyprian Wejnert
BACKGROUND: Persons who inject drugs (PWID) are at increased risk of HIV and hepatitis C virus (HCV) infections and premature mortality due to drug overdose. Medication for opioid use disorder (MOUD), such as methadone or buprenorphine, reduces injecting behaviors, HIV and HCV transmission, and mortality from opioid overdose. Using data from National HIV Behavioral Surveillance, we evaluated the unmet need for MOUD among PWID in 23 U.S. cities. METHODS: PWID were recruited by respondent-driven sampling, interviewed, and tested for HIV...
February 28, 2024: Drug and Alcohol Dependence
https://read.qxmd.com/read/38456707/pharmacokinetics-of-long-acting-lenacapavir-in-participants-with-hepatic-or-renal-impairment
#37
JOURNAL ARTICLE
Vamshi Jogiraju, Elijah Weber, Jason Hindman, Steve West, John Ling, Martin Rhee, Sandhya Girish, Ramesh Palaparthy, Renu Singh
Lenacapavir is a novel, first-in-class, multistage inhibitor of HIV-1 capsid function approved for the treatment of multidrug-resistant HIV-1 infection in combination with other antiretrovirals for heavily treatment-experienced people with HIV. Two Phase 1, open-label, parallel-group, single-dose studies assessed the pharmacokinetics (PK) of lenacapavir in participants with moderate hepatic impairment [Child-Pugh-Turcotte (CPT) Class B: score 7-9] or severe renal impairment [15 ≤ creatinine clearance (CLcr) ≤29 mL/min] to inform lenacapavir dosing in HIV-1-infected individuals with organ impairment...
March 8, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38456165/temporal-trends-in-hcv-treatment-uptake-and-success-among-people-who-inject-drugs-in-baltimore-md-since-the-introduction-of-direct-acting-antivirals
#38
JOURNAL ARTICLE
Catelyn R Coyle, Rachel E Gicquelais, Becky L Genberg, Jacquie Astemborski, Oluwaseun Falade-Nwulia, Gregory D Kirk, David L Thomas, Shruti H Mehta
BACKGROUND: Although hepatitis C virus (HCV) can be cured by direct acting antivirals (DAA), uptake is not well characterized for people who inject drugs (PWID). METHODS: Among 1,130 participants of a community-based cohort of PWID with chronic HCV, we longitudinally characterized HCV treatment uptake and cure early (2014-2016) and later (2017-2020). RESULTS: Cumulative HCV treatment uptake increased from 4% in 2014 to 68% in 2020 and the percent with HCV viremia declined from nearly 100% to 33%...
December 2023: Drug and Alcohol Dependence
https://read.qxmd.com/read/38455604/evaluating-the-impact-of-triple-elimination-program-for-mother-to-child-transmission-of-hiv-syphilis-and-hepatitis-b-in-indonesia
#39
JOURNAL ARTICLE
Buti A Azhali, Djatnika Setiabudi, Anggraini Alam
Indonesian government launched a triple elimination program to eliminate mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV), syphilis, and hepatitis B in 2018, aiming to increase screening uptake among pregnant women during antenatal visits and to reduce the rates of these infections in children less than 50 per 100,000 live births. Despite this initiative, a thorough assessment of its effectiveness, particularly in Bandung, the capital city of West Java, as one of the most densely populated cities in Indonesia with a high HIV incidence, has yet to be conducted...
December 2023: Narra J
https://read.qxmd.com/read/38454356/the-burden-of-skin-and-soft-tissue-bone-and-joint-infections-in-an-australian-cohort-of-people-who-inject-drugs
#40
JOURNAL ARTICLE
B Morgan, R Lancaster, B Boyagoda, R Ananda, L O Attwood, D Jacka, I Woolley
INTRODUCTION: There are currently limited data regarding the clinical and economic significance of skin and soft tissue infections (SSTI) and bone and joint infections in Australian people who inject drugs (PWID). METHODS: Retrospective cohort study in adult PWID admitted to Monash Health, a large heath care network with six hospitals in Victoria, Australia. Inpatients were identified using administrative datasets and International Classification of Disease (ICD-10) coding for specific infection-related conditions...
March 7, 2024: BMC Infectious Diseases
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