Yue An, Changyong Xu, Wenmin Liu, Ji Jiang, Pengfei Ye, Mei Yang, Weihua Zhu, Jingjing Yu, Manman Yu, Wuyi Sun, Jian Hong, Huan Qiu, Wei Wei, Shihao Zhang
The renin-angiotensin system (RAS) has been recognized as a crucial contributor to the development of liver fibrosis, and AT2R, an essential component of RAS, is involved in the progression of liver fibrosis. However, the underlying mechanisms by which AT2R modulates liver fibrosis remain elusive. Here, we report that AT2R was induced to be highly expressed during the progression of liver fibrosis, and the elevated AT2R attenuates liver fibrosis by suppressing IRE1α-XBP1 pathway. In this study, we found that AT2R is not expressed in the no cirrhotic adult liver, but is induced expression during liver fibrosis in both cirrhotic patients and fibrotic mice models...
October 20, 2023: Cellular Signalling