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https://www.readbyqxmd.com/read/28211642/biomechanical-strain-exacerbates-inflammation-on-a-progeria-on-a-chip-model
#1
João Ribas, Yu Shrike Zhang, Patrícia R Pitrez, Jeroen Leijten, Mario Miscuglio, Jeroen Rouwkema, Mehmet Remzi Dokmeci, Xavier Nissan, Lino Ferreira, Ali Khademhosseini
Organ-on-a-chip platforms seek to recapitulate the complex microenvironment of human organs using miniaturized microfluidic devices. Besides modeling healthy organs, these devices have been used to model diseases, yielding new insights into pathophysiology. Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease showing accelerated vascular aging, leading to the death of patients due to cardiovascular diseases. HGPS targets primarily vascular cells, which reside in mechanically active tissues...
February 17, 2017: Small
https://www.readbyqxmd.com/read/28207979/a-comparison-of-injuries-in-elite-male-and-female-football-players-a-5-season-prospective-study
#2
Jon Larruskain, Jose A Lekue, Nerea Diaz, Adrian Odriozola, Susana M Gil
The aim was to compare the epidemiology of injuries between elite male and female football players from the same club. Injuries and individual exposure time in a male team and a female team, both playing in the Spanish first division, were prospectively recorded by the club's medical staff for five seasons (2010-2015) following the FIFA consensus statement. Total, training and match exposure hours per player-season were 20% higher for men compared to women (P < 0.01). Total, training and match injury incidence were 30-40% higher in men (P ≤ 0...
February 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28207292/occurrence-of-toxoplasma-gondii-in-carcasses-of-pigs-reared-in-intensive-systems-in-northern-italy
#3
Roberto Papini, Pierluigi di Ciccio, Marianna Marangi, Sergio Ghidini, Emanuela Zanardi, Alberto Vergara, Annunziata Giangaspero, Simona Nardoni, Guido Rocchigiani, Francesca Mancianti, Adriana Ianieri
To evaluate the occurrence of Toxoplasma gondii and to genetically characterize its isolates in carcasses of industrial fattening pigs, blood, diaphragm, and heart samples were collected from 375 carcasses of pigs slaughtered to be processed for Parma ham production. Pigs had been bred on approved farms (n = 75) located in the so-called Food Valley in Italy. Sera were examined for immunoglobulin G antibodies to T. gondii by modified agglutination test (MAT). Both heart and diaphragm samples from seropositive carcasses were processed for the presence of T...
February 16, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28205142/stepwise-morphological-changes-and-cytoskeletal-reorganization-of-human-mesenchymal-stem-cells-treated-by-short-time-cyclic-uniaxial-stretch
#4
Azim Parandakh, Mohammad Tafazzoli-Shadpour, Mohammad-Mehdi Khani
This study aimed to investigate stepwise remodeling of human mesenchymal stem cells (hMSCs) in response to cyclic stretch through rearrangement and alignment of cells and cytoskeleton regulation toward smooth muscle cell (SMC) fate in different time spans. Image analysis techniques were utilized to calculate morphological parameters. Cytoskeletal reorganization was observed by investigating F-actin filaments using immunofluorescence staining, and expression level of contractile SMC markers was followed by a quantitative polymerase chain reaction method...
February 15, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28203586/comparison-of-kinematics-and-tibiofemoral-contact-pressures-for-native-and-transplanted-lateral-menisci
#5
Patrick C McCulloch, Donald Dolce, Hugh L Jones, Andrea Gale, Michael G Hogen, Jason Alder, Jeremiah E Palmer, Philip C Noble
BACKGROUND: Lateral meniscus transplantation is a proven treatment option for the meniscus-deficient knee, yet little is known about meniscal kinematics, strain, and tibiofemoral contact pressure changes after transplantation or the effect of altered root position in lateral meniscus transplantation. PURPOSE: To compare the native lateral meniscal kinematics, strain, and tibiofemoral contact pressures to a best-case scenario meniscus transplant with perfectly matched size and position and to determine how sensitive these factors are to subtle changes in shape and position by using a nonanatomic meniscus transplant position...
December 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28201995/zoonotic-necrotizing-myositis-caused-by-streptococcus-equi-subsp-zooepidemicus-in-a-farmer
#6
Bård Reiakvam Kittang, Veronika Kuchařová Pettersen, Oddvar Oppegaard, Dag Harald Skutlaberg, Håvard Dale, Harald G Wiker, Steinar Skrede
BACKGROUND: Streptococcus equi subsp. zooepidemicus is a beta-hemolytic group C streptococcus mainly causing infections in domesticated animals. Here we describe the first case of zoonotic necrotizing myositis caused by this bacterium. CASE PRESENTATION: The patient was a 73-year-old, previously healthy farmer with two asymptomatic Shetland ponies in his stable. After close contact with the ponies while feeding them, he rapidly developed erythema of his left thigh and sepsis with multiple organ failure...
February 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28197393/preclinical-efficacy-and-safety-of-the-ty21a-vaccine-strain-for-intravesical-immunotherapy-of-non-muscle-invasive-bladder-cancer
#7
Sonia Domingos-Pereira, Valérie Cesson, Mathieu F Chevalier, Laurent Derré, Patrice Jichlinski, Denise Nardelli-Haefliger
Intravesical Bacillus-Calmette-Guérin (BCG) immunotherapy can reduce recurrence/progression of non-muscle-invasive bladder cancer (NMIBC), although significant adverse events and treatment failure argue for alternative options. Here, we examined whether another attenuated live vaccine, Vivotif/Ty21a, used since more than 30 y against typhoid fever, may be safely used intravesically to improve bladder-tumor treatment. Mice-bearing MB49 orthotopic bladder-tumors treated with intravesical Ty21a or BCG were compared for survival and bacteria recovery...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28195345/in-vivo-measurements-of-human-neck-skin-elasticity-using-mri-and-finite-element-modeling
#8
Yunqiang An, Changjin Ji, Yong Li, Jianxia Wang, Xinyue Zhang, Yaqi Huang
PURPOSE: The assessment of mechanical properties of the human skin is very important in investigating the mechanism of obstructive sleep apnea, a common disorder characterized by repetitive collapse and obstruction of the upper airway during sleep. In this study, a unique method, combining magnetic resonance imaging (MRI) and finite element modeling (FEM), was developed to obtain the value of the in vivo elastic modulus of the neck skin. MEHTHOD: A total of 22 subjects, 16 males and 6 females, were recruited to participate in the MRI studies...
February 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28194660/a-novel-apparatus-for-the-multifaceted-evaluation-of-arterial-function-through-transmural-pressure-manipulation
#9
Toshiyuki Yaguchi, Yalin Cong, Kenji Shimo, Takahiro Kurokawa, Shukei Sugita, Kazuaki Nagayama, Hiroshi Masuda, Takeo Matsumoto
A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure-strain elastic modulus (E p). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial artery. Endothelial function was measured via a standard flow-mediated dilation (FMD) protocol. Smooth muscle function was evaluated via a myogenic contraction of the artery following the application of negative pressure to the chamber and was named pressure-mediated contraction (PMC)...
February 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28188469/investigation-of-interaction-phenomena-between-crural-fascia-and-muscles-by-using-a-three-dimensional-numerical-model
#10
Piero G Pavan, Paola Pachera, Antonella Forestiero, Arturo N Natali
The focus of this work is the numerical modeling of the anterior compartment of the human leg with particular attention to crural fascia. Interaction phenomena between fascia and muscles are of clinical interest to explain some pathologies, as the compartment syndrome. A first step to enhance knowledge on this topic consists in the investigation of fascia biomechanical role and its interaction with muscles in physiological conditions. A three-dimensional finite element model of the anterior compartment is developed based on anatomical data, detailing the structural conformation of crural fascia, composed of three layers, and modeling the muscles as a unique structure...
February 10, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28186492/requirement-of-myomaker-mediated-stem-cell-fusion-for-skeletal-muscle-hypertrophy
#11
Qingnian Goh, Douglas P Millay
Fusion of skeletal muscle stem/progenitor cells is required for proper development and regeneration, however the significance of this process during adult muscle hypertrophy has not been explored. In response to muscle overload after synergist ablation in mice, we show that myomaker, a muscle specific membrane protein essential for myoblast fusion, is activated mainly in muscle progenitors and not myofibers. We rendered muscle progenitors fusion-incompetent through genetic deletion of myomaker in muscle stem cells and observed a complete reduction of overload-induced hypertrophy...
February 10, 2017: ELife
https://www.readbyqxmd.com/read/28185025/constipation-pathophysiology-and-current-therapeutic-approaches
#12
Amol Sharma, Satish Rao
Chronic constipation is a common, persistent condition affecting many patients worldwide, presenting significant economic burden and resulting in substantial healthcare utilization. In addition to infrequent bowel movements, the definition of constipation includes excessive straining, a sense of incomplete evacuation, failed or lengthy attempts to defecate, use of digital manoeuvres for evacuation of stool, abdominal bloating, and hard consistency of stools. After excluding secondary causes of constipation, chronic idiopathic or primary constipation can be classified as functional defecation disorder, slow-transit constipation (STC), and constipation-predominant irritable bowel syndrome (IBS-C)...
February 10, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28176355/strain-shielding-inspired-re-design-of-proximal-femoral-stems-for-total-hip-arthroplasty
#13
Myriam Cilla, Sara Checa, Georg N Duda
A large number of hip prosthesis with different designs have been developed. However, the influence of hip implant design changes on the strains induced in the bone remains unclear. The purpose of this study is to better understand the mechanics of short stem total hip arthroplasty. Specifically, it investigates whether strain shielding can be avoided by changing implant shape and/or material properties. It is hypothesized that the re-design of existing implant designs can result in further reduction of strain shielding and thus keep bone loss minimal following total hip replacement...
February 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28169093/subjective-and-objective-voice-assessments-after-recurrent-laryngeal-nerve-preserved-total-thyroidectomy
#14
Chariton E Papadakis, Panagiota Asimakopoulou, Efklidis Proimos, George Perogamvrakis, Effrosyni Papoutsaki, Theognosia Chimona
OBJECTIVES: This study aims to investigate early voice changes after total thyroidectomy, to assess the improved parameters in intermediate postoperative intervals, to evaluate the effect of age on voice after thyroidectomy, and to determine the correlation between the objective and the subjective method outcomes. STUDY DESIGN: This is a prospective, nonrandomized study. MATERIALS AND METHODS: One hundred ninety-one participants, divided into two age groups, underwent three full voice assessments (preoperatively and 1 and 8 weeks after thyroidectomy) by means of videostroboscopy, perceptual evaluation, acoustic analysis, aerodynamic evaluation, and a self-evaluation questionnaire...
February 3, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28168080/the-femoral-neck-mechanoresponse-to-hip-extensors-exercise-a-case-study
#15
Saulo Martelli, Hossein Mokhtarzadeh, Peter Pivonka, Peter R Ebeling
Physical activity is recommended to prevent age-related bone loss. However, the proximal femur mechanoresponse is variable, possibly because of a muscle-dependant mechanoresponse. We compared the proximal femur response with the femoral strain pattern generated by the hip extensor muscles. A healthy participant underwent a six-month unilateral training of the hip extensor muscles using a resistance weight regularly adjusted to the 80% of the one-repetition maximum weight. DXA-based measurements of the areal Bone Mineral Density (aBMD) in the exercise leg were adjusted for changes in the control leg...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28167917/forced-running-endurance-is-influenced-by-gene-s-on-mouse-chromosome-10
#16
Mindaugas Kvedaras, Petras Minderis, Andrej Fokin, Aivaras Ratkevicius, Tomas Venckunas, Arimantas Lionikas
Phenotypic diversity between laboratory mouse strains provides a model for studying the underlying genetic mechanisms. The A/J strain performs poorly in various endurance exercise models. The aim of the study was to test if endurance capacity and contractility of the fast- and slow-twitch muscles are affected by the genes on mouse chromosome 10. The C57BL/6J (B6) strain and C57BL/6J-Chr 10(A/J)/NaJ (B6.A10) consomic strain which carries the A/J chromosome 10 on a B6 strain background were compared. The B6.A10 mice compared to B6 were larger in body weight (p < 0...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28167182/calf-stretching-in-correct-alignment-an-important-consideration-in-plantar-fasciopathies
#17
Mark Silvester
Stretching of the calf muscles is important in the treatment of plantar fasciopathy. In order to correctly stretch the calf muscles without strain on the plantar fascia the correct alignment of the lower limb should be maintained. A clinical method of achieving this is presented along with a practical guide to assisting the patient to become familiar with correct lower limb alignment.
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28166894/the-influence-of-a-semi-reclined-seated-posture-on-head-and-neck-kinematics-and-muscle-activity-while-reading-a-tablet-computer
#18
Ethan C Douglas, Kaitlin M Gallagher
Increased tablet computer usage calls for a proper understanding of potential injury risks from these devices. The purpose of this study was to assess the influence of tablet computer reading postures on head and neck flexion and muscle activity. Nineteen participants completed read a tablet computer in four different postures (standard computer monitor, tablet on a desk, tablet in the lap, semi-reclined with tablet in the lap). Reading the tablet in a semi-reclined trunk posture with the tablet in one's lap increased (p < 0...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28161749/cohen-s-mri-scoring-system-has-limited-value-in-predicting-return-to-play
#19
Bruce Hamilton, Arnlaug Wangensteen, Rod Whiteley, Emad Almusa, Liesel Geertsema, Stephen Targett, Johannes Tol
PURPOSE: Numerous authors have hypothesised that MRI scoring systems provide a valid means of predicting return to play duration following an acute hamstring muscle strain. The purpose is to prospectively investigate the predictive value of the MRI scoring system of Cohen for return to sport (RTS), following an acute hamstring injury. METHODS: Male football (soccer) players (n = 139) with acute onset posterior thigh pain underwent standardised clinical and MRI examinations within 5 days after injury...
February 4, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28159534/chikungunya-virus-an-update-on-the-biology-and-pathogenesis-of-this-emerging-pathogen
#20
REVIEW
Felicity J Burt, Weiqiang Chen, Jonathan J Miner, Deborah J Lenschow, Andres Merits, Esther Schnettler, Alain Kohl, Penny A Rudd, Adam Taylor, Lara J Herrero, Ali Zaid, Lisa F P Ng, Suresh Mahalingam
Re-emergence of chikungunya virus, a mosquito-transmitted pathogen, is of serious public health concern. In the past 15 years, after decades of infrequent, sporadic outbreaks, the virus has caused major epidemic outbreaks in Africa, Asia, the Indian Ocean, and more recently the Caribbean and the Americas. Chikungunya virus is mainly transmitted by Aedes aegypti mosquitoes in tropical and subtropical regions, but the potential exists for further spread because of genetic adaptation of the virus to Aedes albopictus, a species that thrives in temperate regions...
January 31, 2017: Lancet Infectious Diseases
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