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https://www.readbyqxmd.com/read/28812230/simulation-of-left-ventricular-dynamics-using-a-low-order-mathematical-model
#1
Michael J Moulton, Brian D Hong, Timothy W Secomb
The eventual goal of this study is to develop methods for estimating dynamic stresses in the left ventricle (LV) that could be used on-line in clinical settings, based on routinely available measurements. Toward this goal, a low-order theoretical model is presented, in which LV shape is represented using a small number of parameters, allowing rapid computational simulations of LV dynamics. The LV is represented as a thick-walled prolate spheroid containing helical muscle fibers with nonlinear passive and time-dependent active contractile properties...
August 15, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28812040/effect-of-changes-in-artificial-turf-on-sports-injuries-in-male-university-soccer-players
#2
Kohei Fujitaka, Akira Taniguchi, Tsukasa Kumai, Shingo Otuki, Mamoru Okubo, Yasuhito Tanaka
BACKGROUND: Studies comparing the types and severity of trauma and injuries caused by different types of field surfaces have been conducted. However, there have been no studies on sports injuries caused by temporal deterioration of long-pile artificial turf fields and related decreases in the rubber chip and silica sand infill. PURPOSE: To investigate the influence of an artificial turf field on sports injuries in a university soccer team. STUDY DESIGN: Descriptive epidemiological study...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28810996/rhabdomyolysis-after-crawling-military-training
#3
Danit Atias-Varon, Haggai Sherman, Ran Yanovich, Yuval Heled
INTRODUCTION: Rhabdomyolysis is a syndrome characterized by muscle necrosis followed by release of intracellular muscle contents into the circulation. Exertional rhabdomyolysis (ER) occurs in response to nonfamiliar and/or excessive, prolonged, or repetitive exercises, with eccentric characteristics. In military populations, due to the type of intense, all out physical loads, ER is a significant threat, particularly when training under heat stress. However, many other etiologies exist, and clinical presentations vary greatly...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28808631/painless-swollen-calf-muscles-of-a-75-year-old-patient-caused-by-bilateral-venous-malformations
#4
Roderick S M Piekaar, Eline W Zwitser, Paul P A Hedeman Joosten, Joris A Jansen
A 75-year-old man presented with knee pain due to medial osteoarthritis of the knee in the orthopedic outpatient clinic. Conservative treatment was started with steroid infiltration. Besides his knee complaint reported a bilateral painless swollen calf muscle without traumatic cause, and also without any pain at night, fever or medical illness. On physical examination the soleus muscle had a swollen aspect in both calfs. The skin appeared normal without deformities and the arterial pulsations were intact. An X-ray did not show abnormalities in the tibia...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28807935/function-of-the-hypobranchial-muscles-and-hyoidiomandibular-ligament-during-suction-capture-and-bite-processing-in-white-spotted-bamboo-sharks-chiloscyllium-plagiosum
#5
Jason B Ramsay, Cheryl D Wilga
Suction feeding in teleost fish is a power dependant behavior, requiring rapid and forceful expansion of the orobranchial cavity by the hypobranchial and trunk muscles. To increase power production for expansion, many species employ in-series tendons and catch mechanisms to store and release elastic strain energy. Suction feeding sharks such as Chiloscyllium plagiosum lack large in-series tendons on the hypobranchials, yet two of the hypobranchials, the coracohyoideus and coracoarcualis (CH, CA; hyoid depressors), are arranged in-series, and run deep and parallel to a third muscle, the coracomandibularis (CM, jaw depressor)...
August 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28807431/a-prospective-analysis-of-injury-rates-patterns-and-causes-in-cliff-and-splash-diving
#6
Lukas Ernstbrunner, Armin Runer, Paul Siegert, Matthäus Ernstbrunner, Johannes Becker, Thomas Freude, Herbert Resch, Philipp Moroder
INTRODUCTION: Information about injuries and its differences in Cliff Diving (CD) and Splash Diving (SD) are unknown. It was the aim to analyse (1) injury rates, patterns and causes; (2) differences (in injuries) between both disciplines; and to (3) identify targets for future injury prevention interventions. METHODS: From April to November 2013, 81 cliff and 51 splash divers were prospectively surveyed with an encrypted, monthly e-mail-based questionnaire. RESULTS: During a total of 7857h diving with an average diving height of 13 (±7)m, an overall injury rate of 7...
August 5, 2017: Injury
https://www.readbyqxmd.com/read/28806168/mapping-the-mouse-allelome-reveals-tissue-specific-regulation-of-allelic-expression
#7
Daniel Andergassen, Christoph P Dotter, Daniel Wenzel, Verena Sigl, Philipp C Bammer, Markus Muckenhuber, Daniela Mayer, Tomasz M Kulinski, Hans-Christian Theussl, Josef M Penninger, Christoph Bock, Denise P Barlow, Florian M Pauler, Quanah J Hudson
To determine the dynamics of allelic-specific expression during mouse development, we analyzed RNA-seq data from 23 F1 tissues from different developmental stages, including 19 female tissues allowing X chromosome inactivation (XCI) escapers to also be detected. We demonstrate that allelic expression arising from genetic or epigenetic differences is highly tissue-specific. We find that tissue-specific strain-biased gene expression may be regulated by tissue-specific enhancers or by post-transcriptional differences in stability between the alleles...
August 14, 2017: ELife
https://www.readbyqxmd.com/read/28803705/collagen-fibril-organization-in-chicken-and-porcine-skeletal-muscle-perimysium-under-applied-tension-and-compression
#8
Melika Mohammadkhah, Paula Murphy, Ciaran K Simms
The tension/compression asymmetry observed in the stress-stretch response of skeletal muscle is not well understood. The collagen network in the extracellular matrix (ECM) almost certainly plays a major role, but the details are unknown. This paper reports qualitatively and quantitatively on skeletal muscle ECM reorganization during applied deformation using confocal imaging of collagen through use of a fluorescently-tagged specific collagen binding protein (CNA35-EGFP) of porcine and chicken muscle samples under tensile and compressive deformation in both the fibre and cross-fibre directions...
August 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28803536/bovine-viral-diarrhea-virus-1b-fetal-infection-with-extensive-hemorrhage
#9
Robert W Fulton, Anthony W Confer, Nicholas J Sorensen, Julia F Ridpath, Lurinda J Burge
Bovine viral diarrhea virus (BVDV) 1b was isolated from tissues of a term bovine fetus with petechial hemorrhages noted throughout the body and placenta at autopsy. Fresh lung, kidney, thymus, and liver tissues were examined by direct fluorescent antibody testing and were positive for BVDV antigen and negative for bovine herpesvirus 1 antigen. An organ pool of fresh tissues was positive for noncytopathic (NCP) BVDV-1 by virus isolation. BVDV-1b was identified by sequencing of the 5'-UTR region of the genome...
August 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28800920/does-platelet-rich-plasma-lead-to-earlier-return-to-sport-when-compared-with-conservative-treatment-in-acute-muscle-injuries-a-systematic-review-and-meta-analysis
#10
Ujash Sheth, Tim Dwyer, Ira Smith, David Wasserstein, John Theodoropoulos, Sachdeep Takhar, Jaskarndip Chahal
PURPOSE: To compare the time to return to sport and reinjury rate after platelet-rich plasma (PRP) injection versus control therapy (i.e., physiotherapy or placebo injection) in patients with acute grade I or II muscle strains. METHODS: All eligible studies comparing PRP against a control in the treatment of acute (≤7 days) grade I or II muscle strains were identified. The primary outcome was time to return to play. The secondary outcome was the rate of reinjury at a minimum of 6 months of follow-up...
August 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28800593/in-vivo-functional-and-morphological-characterization-of-bone-and-striated-muscle-microcirculation-in-nsg-mice
#11
Haider Mussawy, Lennart Viezens, Gerrit Hauenherm, Malte Schroeder, Christian Schaefer
Organ-specific microcirculation plays a central role in tumor growth, tumor cell homing, tissue engineering, and wound healing. Mouse models are widely used to study these processes; however, these mouse strains often possess unique microhemodynamic parameters, making it difficult to directly compare experiments. The full functional characterization of bone and striated muscle microcirculatory parameters in non-obese diabetic-severe combined immunodeficiency/y-chain; NOD-Prkds IL2rg (NSG) mice has not yet been reported...
2017: PloS One
https://www.readbyqxmd.com/read/28797108/natural-disease-history-of-mouse-models-for-limb-girdle-muscular-dystrophy-types-2d-and-2f
#12
S Pasteuning-Vuhman, K Putker, C L Tanganyika-de Winter, J W Boertje-van der Meulen, L van Vliet, M Overzier, J J Plomp, A Aartsma-Rus, M van Putten
Limb-girdle muscular dystrophy types 2D and 2F (LGMD 2D and 2F) are autosomal recessive disorders caused by mutations in the alpha- and delta sarcoglycan genes, respectively, leading to severe muscle weakness and degeneration. The cause of the disease has been well characterized and a number of animal models are available for pre-clinical studies to test potential therapeutic interventions. To facilitate transition from drug discovery to clinical trials, standardized procedures and natural disease history data were collected for these mouse models...
2017: PloS One
https://www.readbyqxmd.com/read/28782271/comparison-of-nitrergic-signaling-in-circular-and-longitudinal-smooth-muscle-of-murine-ileum
#13
B Voussen, K Beck, N Mauro, J Keppler, A Friebe
BACKGROUND: Gastrointestinal (GI) motility originates from coordinated movements of circular (CM) and longitudinal (LM) smooth muscle. How the two muscle layers react individually to nitrergic input and how they integrate nitrergic signaling is not thoroughly understood. METHODS: We used immunohistochemistry to unveil expression of NO-sensitive guanylyl cyclase (NO-GC) in the ileum. For functional analyses, we measured tone of ileal CM and spontaneous contractions in both ileal muscle layers from mice lacking NO-GC globally (GCKO) and specifically in smooth muscle cells (SMC-GCKO)...
August 7, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28772319/imaging-of-acute-hamstring-muscle-strain-injuries
#14
Simon Dimmick, James M Linklater
No abstract text is available yet for this article.
September 2017: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28771943/overexpression-of-integrin-%C3%AE-11-induces-cardiac-fibrosis-in-mice
#15
Andreas Romaine, Ida W Sørensen, Cédric Zeltz, Ning Lu, Pugazendhi Murugan Erusappan, Arne Olav Melleby, Lili Zhang, Bård Bendiksen, Emma Louise Robinson, Jan Magnus Aronsen, Kate M Herum, Håvard Danielsen, Ivar Sjaastad, Geir Christensen, Donald Gullberg
AIM: To understand the role of the collagen-binding integrin α11 in vivo we have used a classical approach of creating a mouse strain overexpressing integrin α11. A transgenic mouse strain overexpressing α11 in muscle tissues was analysed in the current study with special reference to the heart tissue. METHODS: We generated and phenotyped integrin α11 transgenic (TG) mice by echocardiography, magnetic resonance imaging and histology. Wild-type (WT) mice were subjected to aortic banding (AB) and the expression of integrin α11 was measured in flow cytometry sorted cardiomyocytes and non-myocytes...
August 3, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28763160/crispr-cas9-mediated-targeting-of-the-rosa26-locus-produces-cre-reporter-rat-strains-for-monitoring-cre-loxp-mediated-lineage-tracing
#16
Yuanwu Ma, Lei Yu, Shuo Pan, Shan Gao, Wei Chen, Xu Zhang, Wei Dong, Jing Li, Rui Zhou, Lan Huang, Yunlin Han, Lin Bai, Li Zhang, Lianfeng Zhang
The rat is an important laboratory animal for physiological, toxicological and pharmacological studies. CRISPR/Cas9 is a simple and efficient tool to generate precise genetic modifications in rats, which will promote the accumulation of rat genetic resources and enable more precise studies of gene function. To monitor Cre/loxP-mediated excision in vivo, we generated a Cre reporter rat strain (Rosa26-imCherry) by knockin of a Cre reporter cassette at Rosa26 locus using CRISPR/Cas9. Rosa26-imCherry rats exhibited inducible expression of the mCherry cassette (imCherry) using the Cre/loxP system, whereas normal rats exhibited ubiquitous expression of eGFP but not mCherry in the whole body...
August 1, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28759901/subsequent-injuries-and-early-recurrent-diagnoses-in-elite-rugby-union-players
#17
Sean Williams, Grant Trewartha, Simon Kemp, Matthew J Cross, John H M Brooks, Colin W Fuller, Aileen E Taylor, Keith A Stokes
An eight-season (2005/06-2012/13) prospective cohort design was used to record time-loss injuries in 15 English Premiership teams. Data pertaining to a total of 1 556 players and 9 597 injuries (8 180 subsequent) were included in the analysis. Injuries subsequent to an index injury were classified as (1) New: different site; (2) Local: same site (and different type); or (3) Recurrent: same site and type. The severity of subsequent injuries (days missed) was compared with their related index injury. The proportions of early (<2 months), late (2-12 months) and delayed (>12 months) subsequent injuries were compared across injury classifications and diagnosis groupings...
July 31, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28755868/assessment-of-left-ventricular-function-in-healthy-great-danes-and-in-great-danes-with-dilated-cardiomyopathy-using-speckle-tracking-echocardiography
#18
B Pedro, H Stephenson, C Linney, P Cripps, J Dukes-McEwan
OBJECTIVES: Assess global circumferential and radial systolic and diastolic myocardial function with speckle tracking echocardiography (STE) in healthy Great Danes (GD) and in GD diagnosed with dilated cardiomyopathy (DCM). ANIMALS: Eighty-nine GD were included in the study: 39 healthy (normal group [NORMg]) and 50 diagnosed with DCM (DCMg). METHODS: This was a retrospective study. Signalment and echocardiographic diagnosis were obtained from the medical records of GD assessed between 2008 and 2012...
July 26, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28755280/magnetic-resonance-imaging-patterns-of-mononeuropathic-denervation-in-muscles-with-dual-innervation
#19
REVIEW
Darryl B Sneag, Susan C Lee, Joseph H Feinberg, Darius P Melisaratus, Ian Amber
Magnetic resonance imaging (MRI) of mononeuropathy in muscles with dual innervation depicts geographic denervation corresponding to the affected nerve. Knowledge of the normal distribution of a muscle's neural supply is clinically relevant as partial muscle denervation represents a potential imaging pitfall that can be confused with other pathology, such as muscle strain. This article reviews the normal innervation pattern of extremity muscles with dual supply, providing illustrative examples of mononeuropathy affecting such muscles...
July 28, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28753687/strain-level-dependent-non-equilibrium-anisotropic-viscoelasticity-application-to-the-abdominal-muscle
#20
Marcos Latorre, Francisco/J Montáns
Soft connective tissues sustain large strains of viscoelastic nature. The rate-independent component is frequently modelled by means of anisotropic hyperelastic models. The rate-dependent component is usually modelled through linear rheological models or quasilinear viscoelastic models. These viscoelastic models are unable, in general, to capture the strain-level dependency of the viscoelastic properties present in many viscoelastic tissues. In linear viscoelastic models, strain-level dependency is frequently accounted for by including the dependence of multipliers of Prony series on strains through additional evolution laws, but the determination of the material parameters is a difficult task and the obtained accuracy is usually not sufficient...
July 28, 2017: Journal of Biomechanical Engineering
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