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inferior colliculus

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https://www.readbyqxmd.com/read/29315537/vitamin-transporters-in-mice-brain-with-aging
#1
P Marcos, J González-Fuentes, L Castro-Vázquez, M V Lozano, M J Santander-Ortega, V Rodríguez-Robledo, N Villaseca-González, M M Arroyo-Jiménez
Its high metabolic rate and high polyunsaturated fatty acid content make the brain very sensitive to oxidative damage. In the brain, neuronal metabolism occurs at a very high rate and generates considerable amounts of reactive oxygen species and free radicals, which accumulate inside neurons, leading to altered cellular homeostasis and integrity and eventually irreversible damage and cell death. A misbalance in redox metabolism and the subsequent neurodegeneration increase throughout the course of normal aging, leading to several age-related changes in learning and memory as well as motor functions...
January 8, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29302743/gabaergic-and-non-gabaergic-projections-to-the-superior-colliculus-from-the-auditory-brainstem
#2
Jeffrey G Mellott, Nichole L Beebe, Brett R Schofield
The superior colliculus (SC) contains an auditory space map that is shaped by projections from several subcortical auditory nuclei. Both GABAergic (inhibitory) and excitatory cells contribute to these inputs, but there are contradictory reports regarding the sources of these inputs. We used retrograde tracing techniques in guinea pigs to identify cells in the auditory brainstem that project to the SC. We combined retrograde tracing with immunohistochemistry for glutamic acid decarboxylase (GAD) to identify putative GABAergic cells that participate in this pathway...
January 4, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29277284/alcohol-withdrawal-upregulates-mrna-encoding-for-cav2-1-%C3%AE-1-subunit-in-the-rat-inferior-colliculus
#3
Jamila Newton, Shubhankar Suman, Luli R Akinfiresoye, Kamal Datta, David M Lovinger, Prosper N'Gouemo
We previously reported increased current density through P-type voltage-gated Ca2+ channels in inferior colliculus (IC) neurons during alcohol withdrawal. However, the molecular correlate of this increased P-type channel current is currently unknown. Here, we probe changes in mRNA and protein expression of the pore-forming CaV2.1-α1 (P/Q-type) subunits in IC neurons during the course of alcohol withdrawal-induced seizures (AWSs). Rats received three daily doses of ethanol or the vehicle every 8 h for 4 consecutive days...
February 2018: Alcohol
https://www.readbyqxmd.com/read/29274430/divergent-brain-changes-in-two-audiogenic-rat-strains-a-voxel-based-morphometry-and-diffusion-tensor-imaging-comparison-of-the-genetically-epilepsy-prone-rat-gepr-3-and-the-wistar-audiogenic-rat-war
#4
Yichien Lee, Olga C Rodriguez, Chris Albanese, Victor Rodrigues Santos, José Antônio Cortes de Oliveira, Ana Luiza Ferreira Donatti, Artur Fernandes, Norberto Garcia-Cairasco, Prosper N'Gouemo, Patrick A Forcelli
Acoustically evoked seizures (e.g., audiogenic seizures or AGS) are common in models of inherited epilepsy and occur in a variety of species including rat, mouse, and hamster. Two models that have been particularly well studied are the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR) strains. Acute and repeated AGS, as well as comorbid conditions, displays a close phenotypic overlap in these models. Whether these similarities arise from convergent or divergent structural changes in the brain remains unknown...
December 20, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29247467/release-from-informational-masking-by-auditory-stream-segregation-perception-and-its-neural-correlate
#5
Lena-Vanessa Dolležal, Sandra Tolnai, Rainer Beutelmann, Georg M Klump
In the analysis of acoustic scenes we easily miss sounds or are insensitive to sound features that are salient if presented in isolation. This insensitivity that is not due to interference in the inner ear is termed informational masking (IM). So far, the cellular mechanisms underlying IM remained elusive. Here, we apply a sequential IM paradigm to humans and gerbils using a sound-level-increment-detection task determining the sensitivity to target tones in a background of standard (same frequency) and distracting tones (varying in level and frequency)...
December 15, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29242823/processing-of-natural-echolocation-sequences-in-the-inferior-colliculus-of-seba-s-fruit-eating-bat-carollia-perspicillata
#6
M Jerome Beetz, Sebastian Kordes, Francisco García-Rosales, Manfred Kössl, Julio C Hechavarría
For the purpose of orientation, echolocating bats emit highly repetitive and spatially directed sonar calls. Echoes arising from call reflections are used to create an acoustic image of the environment. The inferior colliculus (IC) represents an important auditory stage for initial processing of echolocation signals. The present study addresses the following questions: (1) how does the temporal context of an echolocation sequence mimicking an approach flight of an animal affect neuronal processing of distance information to echo delays? (2) how does the IC process complex echolocation sequences containing echo information from multiple objects (multiobject sequence)? Here, we conducted neurophysiological recordings from the IC of ketamine-anaesthetized bats of the species Carollia perspicillata and compared the results from the IC with the ones from the auditory cortex (AC)...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29238582/inferior-colliculus-syndrome-clinical-magnetic-resonance-microscopy-anatomic-analysis-on-a-7-t-system
#7
Ingrid L Kwee, Hitoshi Matsuzawa, Kazunori Nakada, Yukihiko Fujii, Tsutomu Nakada
We performed detailed structural analysis of a case of a unilateral lesion of the inferior colliculus using magnetic resonance microscopy on a 7 T system. A 36-year-old right-handed man had an intracerebral hemorrhage circumscribed to the right inferior colliculus. Following recovery from the acute phase, he had only residual left ear tinnitus and left trochlear palsy and no hearing loss. Microscopic imaging analysis on a 7 T magnetic resonance imaging system demonstrated a chronic lesion confined primarily to the right central nucleus of the inferior colliculus...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29235497/pharmacological-modulation-of-kv3-1-mitigates-auditory-midbrain-temporal-processing-deficits-following-auditory-nerve-damage
#8
Anna R Chambers, Nadia Pilati, Pooja Balaram, Charles H Large, Leonard K Kaczmarek, Daniel B Polley
Higher stages of central auditory processing compensate for a loss of cochlear nerve synapses by increasing the gain on remaining afferent inputs, thereby restoring firing rate codes for rudimentary sound features. The benefits of this compensatory plasticity are limited, as the recovery of precise temporal coding is comparatively modest. We reasoned that persistent temporal coding deficits could be ameliorated through modulation of voltage-gated potassium (Kv) channels that regulate temporal firing patterns...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229554/the-effect-of-complex-acoustic-environment-during-early-development-on-the-responses-of-auditory-cortex-neurons-in-rats
#9
Kateryna Pysanenko, Zbyněk Bureš, Jiří Lindovský, Josef Syka
Acoustical environment plays an important role during the maturation of the auditory system. It has been shown that the sensory inputs to the developing centres influence the development of the structure of projections, neuronal responsiveness, excitatory-inhibitory balance, or tonotopical arrangement, throughout the auditory pathway. Our previous study (Bures et al., 2014) showed that rats reared in a complex acoustic environment (spectrally and temporally modulated sound reinforced by an active behavioural paradigm with a positive feedback) exhibit permanently improved response characteristics of the inferior colliculus (IC) neurons...
December 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/29156225/differences-between-auditory-frequency-following-responses-and-onset-responses-intracranial-evidence-from-rat-inferior-colliculus
#10
Qian Wang, Liang Li
A periodic sound, such as a pure tone, evokes both transient onset field-potential responses and sustained frequency-following responses (FFRs) in the auditory midbrain, the inferior colliculus (IC). It is not clear whether the two types of responses are based on the same or different neural substrates. Although it has been assumed that FFRs are based on phase locking to the periodic sound, the evidence showing the direct relationship between the FFR amplitude and the phase-locking strength is still lacking...
November 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/29155767/a-wireless-bidirectional-interface-for-in-vivo-recording-and-stimulation-of-neural-activity-in-freely-behaving-rats
#11
Liana Melo-Thomas, K-Alexander Engelhardt, Uwe Thomas, Dirk Hoehl, Sascha Thomas, Markus Wöhr, Bjoern Werner, Frank Bremmer, Rainer K W Schwarting
In vivo electrophysiology is a powerful technique to investigate the relationship between brain activity and behavior at a millisecond and micrometer scale. However, current methods mostly rely on tethered cable recordings or only use unidirectional systems, allowing either recording or stimulation of neural activity, but not at the same time or same target. Here, a new wireless, bidirectional device for simultaneous multichannel recording and stimulation of neural activity in freely behaving rats is described...
November 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29143124/the-effect-of-inhibition-on-stimulus-specific-adaptation-in-the-inferior-colliculus
#12
Yaneri A Ayala, Manuel S Malmierca
The inferior colliculus is a center of convergence for inhibitory and excitatory synaptic inputs that may be activated simultaneously by sound stimulation. Stimulus repetition may generate response habituation by changing the efficacy of neuron's synaptic inputs. Specialized IC neurons reduce their response to repetitive tones, but restore their firing when a different and infrequent tone occurs, a phenomenon known as stimulus specific adaptation. Here, using the microiontophoresis technique, we determined the role of GABAA-, GABAB-, and glycinergic receptors in stimulus-specific adaptation (SSA)...
November 15, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29130968/immunohistochemical-localization-of-calbindin-d28k-parvalbumin-and-calretinin-in-the-superior-olivary-complex-of-circling-mice
#13
Jin-Koo Lee, Dhiraj Maskey, Myeung Ju Kim
The circling mouse serves as a hearing loss model. It has spontaneous tmie gene mutations that cause hair cell and cochlear degeneration. However, little is known about the role of the tmie gene in superior olivary complex (SOC) regions, in which sound information from the two ears is integrated and primarily relayed to the nuclei of the lateral lemniscus and inferior colliculus. Several studies have reported that abnormal calcium (Ca2+) homeostasis is associated with the pathology of hearing loss. This study investigated the distribution of Ca2+-binding proteins (CaBPs), such as calbindin D28k, parvalbumin, and calretinin, in the SOC of the circling mouse on postnatal day 16...
November 4, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29116453/the-role-of-the-pulvinar-in-spatial-visual-attention
#14
Ricardo Gattass, Juliana G M Soares, Bruss Lima
This chapter deals with the role of the pulvinar in spatial visual attention. There are at least two aspects in which the pulvinar seems to be instrumental for selective visual processes. The first aspect concerns pulvinar connectivity pattern. The pulvinar is connected with brain regions known to be playing a role in attentional mechanisms, such as area V4, the superior colliculus (SC), and the inferior parietal cortex (IP). Additionally, the pulvinar is richly interconnected with multiple cortical areas. This enables the pulvinar to serve as a hub for brain communication, potentially gating the flow of information across different regions...
2018: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/29112481/diffusion-tensor-imaging-of-central-auditory-pathways-in-patients-with-sensorineural-hearing-loss-a-systematic-review
#15
Osama Tarabichi, Elliott D Kozin, Vivek V Kanumuri, Samuel Barber, Satra Ghosh, Kevin R Sitek, Katherine Reinshagen, Barbara Herrmann, Aaron K Remenschneider, Daniel J Lee
Objective The radiologic evaluation of patients with hearing loss includes computed tomography and magnetic resonance imaging (MRI) to highlight temporal bone and cochlear nerve anatomy. The central auditory pathways are often not studied for routine clinical evaluation. Diffusion tensor imaging (DTI) is an emerging MRI-based modality that can reveal microstructural changes in white matter. In this systematic review, we summarize the value of DTI in the detection of structural changes of the central auditory pathways in patients with sensorineural hearing loss...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29101749/analysis-of-erk1-2-kinases-in-the-inferior-colliculus-of-rats-genetically-prone-to-audiogenic-seizures-during-postnatal-development
#16
E V Chernigovskaya, O O Lebedenko, A V Nidenfyur, L S Nikitina, M V Glazova
The activity of ERK1/2 kinases in the quadrigemina inferior colliculus of Krushinsky-Molodkina rats of different age, which are characterized by an increased seizure readiness compared to Wistar rats, was analyzed. An increased (probably genetically determined) activity of these enzymes during the development of epileptiform activity in ontogeny was found, which may be the cause of abnormalities in the neurotransmitter system functioning.
September 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29071963/-effect-of-electroacupuncture-on-expression-of-catechol-o-methyltransferase-in-the-inferior-colliculus-and-auditory-cortex-in-age-related-hearing-loss-guinea-pigs
#17
Shu-Yun Liu, Li-Qiang Deng, Ye Yang, Ze-Deng Yin
OBJECTIVE: To observe the expression of catechol-O-methyltransferase (COMT) in inferior colliculus and auditory cortex of guinea pigs with age-related hearing loss(AHL) induced by D-galactose, so as to explore the possible mechanism of electroacupuncture(EA) underlying preventing AHL. METHODS: Thirty 3-month-old guinea pigs were randomly divided into control group, model group and EA group(n=10 in each group), and ten 18-month-old guinea pigs were allocated as elderly group...
April 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29069619/breakdown-of-excitability-by-attenuated-prv-152-infection-in-auditory-brainstem-neurons-of-mongolian-gerbils
#18
Christian P Porres, Benedikt Grothe, Felix Felmy
Pseudorabies virus (PRV), a neurovirulent α-herpesvirus, spreads between neurons at synaptic connections. PRV-infected neurons have been shown to exhibit functional deficits with the attenuated PRV152 Bartha strain negatively influencing neuronal functioning in in vitro model systems. However, the impact of this attenuated PRV152 Bartha strain on the native central nervous system has not been fully explored. Using a combination of in vivo stereotactic injections and post-hoc in vitro whole-cell recordings, we investigated the functional impact of PRV152 Bartha in the auditory system of juvenile Mongolian gerbils...
October 22, 2017: Neuroscience
https://www.readbyqxmd.com/read/29061702/presynaptic-neuronal-nicotinic-receptors-differentially-shape-select-inputs-to-auditory-thalamus-and-are-negatively-impacted-by-aging
#19
Sarah Y Sottile, Troy A Hackett, Rui Cai, Lynne Ling, Daniel A Llano, Donald M Caspary
Acetylcholine is a potent neuromodulator capable of modifying patterns of acoustic information flow. In auditory cortex, cholinergic systems have been shown to increase salience/gain while suppressing extraneous information. However, the mechanism by which cholinergic circuits shape signal processing in the auditory thalamus (medial geniculate body, MGB) is poorly understood. The present study, in male Fischer Brown Norway rats, seeks to determine the location and function of presynaptic neuronal nicotinic acetylcholine receptors (nAChRs) at the major inputs to MGB and characterize how nAChRs change during aging...
October 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29060273/auditory-responses-to-short-wavelength-infrared-neural-stimulation-of-the-rat-cochlear-nucleus
#20
Bin Jiang, Nan Xia, Xing Wang, Ning Hu, Xiao Y Wu, Yi Zhou, Wen S Hou
Pulsed Infrared laser is well-known for its high spatial resolution and contact-free stimulation mode. In order to improve the current auditory brainstem implants (ABI), 980 nm-short-wavelength infrared light was applied to stimulate the cochlear nucleus of rats. Single neural activity from contralateral inferior colliculus was recorded during laser stimulation. Animal experimental results showed that 980 nm laser could not directly activate neurons in cochlear nucleus and a photo-acoustic response was observed during stimulation, however, 980 nm laser produces an inhibitory effect on neural responses to sounds; After we added carbon nanoparticles onto the surface of animal cochlear nucleus, 980 nm laser could directly stimulate neurons and no interference between adjacent recording channels was observed...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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