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inferior colliculus

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https://www.readbyqxmd.com/read/28097439/modeling-responses-in-the-superior-paraolivary-nucleus-implications-for-forward-masking-in-the-inferior-colliculus
#1
Nima Salimi, Muhammad S A Zilany, Laurel H Carney
A phenomenological model of the responses of neurons in the superior paraolivary nucleus (SPON) of the rodent is presented in this study. Pure tones at the characteristic frequency (CF) and broadband noise stimuli evoke offset-type responses in these neurons. SPON neurons also phase-lock to the envelope of sinusoidally amplitude-modulated (SAM) stimuli for a range of modulation frequencies. Model SPON neuron received inhibitory input that was relayed by the ipsilateral medial nucleus of the trapezoid body from the contralateral model ventral cochlear nucleus neuron...
January 17, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28078738/dorsal-pallidal-neurons-directly-link-the-nidopallium-and-midbrain-in-the-zebra-finch-taeniopygia-guttata
#2
J Martin Wild
The dorsal pallidum in birds is considered similar, if not homologous, to the globus pallidus (GP) of mammals. The dorsal pallidum projects to both thalamic and midbrain targets similar to the direct and indirect pathways arising from the internal and external segments of the GP. In the present study retrograde and anterograde tracing studies revealed a previously undescribed projection of the avian dorsal pallidum. This arises from a specific dorsomedial component, which terminates in the intercollicular nucleus and partly surrounds the avian equivalent of the central nucleus of the inferior colliculus...
January 12, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28077288/micro-endoscopic-system-for-functional-assessment-of-neural-circuits-in-deep-brain-regions-simultaneous-optical-and-electrical-recordings-of-auditory-responses-in-mouse-s-inferior-colliculus
#3
Hidetaka Yashiro, Ichiro Nakahara, Kazuo Funabiki, Hiroshi Riquimaroux
In vivo Ca(2+) imaging is a powerful method for the functional assessment of neural circuits. Although multi-photon excitation fluorescence microscopy has been widely used, observation of circuits in deep brain regions remains challenging. Recently, observing these deep regions has become possible via an endoscope consisting of an optical fiber bundle or gradient-index lens. We have designed a micro-endoscope system that enables simultaneous optical recording of fluorescence and electrical recording of neural activity...
January 7, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28043881/simultaneously-evoked-auditory-potentials-seap-a-new-method-for-concurrent-measurement-of-cortical-and-subcortical-auditory-evoked-activity
#4
Christopher Slugocki, Daniel Bosnyak, Laurel J Trainor
Recent electrophysiological work has evinced a capacity for plasticity in subcortical auditory nuclei in human listeners. Similar plastic effects have been measured in cortically-generated auditory potentials but it is unclear how the two interact. Here we present Simultaneously-Evoked Auditory Potentials (SEAP), a method designed to concurrently elicit electrophysiological brain potentials from inferior colliculus, thalamus, and primary and secondary auditory cortices. Twenty-six normal-hearing adult subjects (mean 19...
December 30, 2016: Hearing Research
https://www.readbyqxmd.com/read/28009231/the-superior-fovea-triangle-approach-a-novel-safe-entry-zone-to-the-brainstem
#5
Kaan Yagmurlu, M Yashar S Kalani, Mark C Preul, Robert F Spetzler
The authors describe a safe entry zone, the superior fovea triangle, on the floor of the fourth ventricle for resection of deep dorsal pontine lesions at the level of the facial colliculus. Clinical data from a patient undergoing a suboccipital telovelar transsuperior fovea triangle approach to a deep pontine cavernous malformation were reviewed and supplemented with 6 formalin-fixed adult human brainstem and 2 silicone-injected adult human cadaveric heads using the fiber dissection technique to illustrate the utility of this novel safe entry zone...
December 23, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28003409/a-circuit-for-saccadic-suppression-in-the-primate-brain
#6
Rebecca A Berman, James Cavanaugh, Kerry McAlonan, Robert H Wurtz
Saccades should cause us to see a blur as the eyes sweep across a visual scene. Specific brain mechanisms prevent this by producing suppression during saccades. Neuronal correlates of such suppression were first established in the visual superficial layers of the superior colliculus (SC) and subsequently have been observed in cortical visual areas, including the middle temporal visual area (MT). In this study, we investigated suppression in a recently identified circuit linking visual SC (SCs) to MT through the inferior pulvinar (PI)...
December 21, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27997696/the-organization-of-frequency-and-binaural-cues-in-the-gerbil-inferior-colliculus
#7
Gilberto David Graña, Kendall A Hutson, Alexandra Badea, Andrew Pappa, William Scott, Douglas C Fitzpatrick
The inferior colliculus (IC) is the common target of separate pathways that transmit different types of auditory information. Beyond tonotopy, little is known about the organization of response properties within the 3-dimensional layout of the auditory midbrain in most species. A case where the functional properties of neurons can be readily characterized and related to specific pathways is ITD processing. To characterize the representation of ITDs relative to the frequency and hodological organization of the IC, the properties of neurons were recorded and the sites recovered histologically...
December 20, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27993512/audiogenic-seizure-activity-following-hsv-1-gad65-sense-or-antisense-injection-into-inferior-colliculus-of-long-evans-rat
#8
James R Coleman, Karen C Thompson, Marlene A Wilson, Steven P Wilson
Herpes virus technology involving manipulation of GAD65 was used to study effects on audiogenic seizures (AGS). Audiogenic seizure behaviors were examined following injections of replication-defective herpes simplex virus (HSV-1) vectors incorporating sense or antisense toward GAD65 along with 10% lac-Z into the central nucleus of inferior colliculus (CNIC) of Long-Evans rats. In seizure-sensitive animals developmentally primed by intense sound exposure, injection of GAD65 in the sense orientation increased wild running latencies and reduced incidence of clonus compared with lac-Z only, unoperated, and vehicle seizure groups...
December 16, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27989950/plastic-changes-along-auditory-pathway-during-salicylate-induced-ototoxicity-hyperactivity-and-cf-shifts
#9
Chen Jiang, Bin Luo, Senthilvelan Manohar, Guang-Di Chen, Richard Salvi
High dose of salicylate, the active ingredient in aspirin, has long been known to induce transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool. These salicylate-induced perceptual disturbances are associated with a massive reduction in the neural output of the cochlea. Paradoxically, the diminished neural output of the cochlea is accompanied by a dramatic increase in sound-evoked activity in the auditory cortex (AC) and several other parts of the central nervous system. Exactly where the increase in neural activity begins and builds up along the central auditory pathway are not fully understood...
October 27, 2016: Hearing Research
https://www.readbyqxmd.com/read/27956352/correlation-between-the-frequency-difference-limen-and-an-index-based-on-principal-component-analysis-of-the-frequency-following-response-of-normal-hearing-listeners
#10
Xiaochen Zhang, Qin Gong
Subcortical phase locking tends to reflect performance differences in tasks related to pitch perception across different types of populations. Enhancement or attenuation in its strength may correspond to population excellence or deficiency in pitch perception. However, it is still unclear whether differences in perceptual capability among individuals with normal hearing can be predicted by subcortical phase locking. In this study, we examined the brain-behavior relationship between frequency-following responses (FFRs) evoked by pure/sweeping tones and frequency difference limens (FDLs)...
December 10, 2016: Hearing Research
https://www.readbyqxmd.com/read/27914298/effects-of-environmental-noise-exposure-on-dna-methylation-in-the-brain-and-metabolic-health
#11
Liqiong Guo, Peng-Hui Li, Hua Li, Elena Colicino, Silvia Colicino, Yi Wen, Ruiping Zhang, Xiaotian Feng, Timothy M Barrow, Akin Cayir, Andrea A Baccarelli, Hyang-Min Byun
Environmental noise exposure is associated with adverse effects on human health including hearing loss, heart disease, and changes in stress-related hormone levels. Alteration in DNA methylation in response to environmental exposures is a well-known phenomenon and it is implicated in many human diseases. Understanding how environmental noise exposures affect DNA methylation patterns may help to elucidate the link between noise and adverse effects on health. In this pilot study we examined the effects of environmental noise exposure on DNA methylation of genes related to brain function and investigated whether these changes are related with metabolic health...
November 30, 2016: Environmental Research
https://www.readbyqxmd.com/read/27905540/the-effects-of-repetitive-transcranial-magnetic-stimulation-in-an-animal-model-of-tinnitus
#12
Wilhelmina H A M Mulders, Vanessa Vooys, Kalina Makowiecki, Alex D Tang, Jennifer Rodger
Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinnitus in some patients, possibly via induction of cortical plasticity involving brain derived neurotrophic factor (BDNF). We examined whether low intensity rTMS (LI-rTMS) alleviates signs of tinnitus in a guinea pig model and whether this involves changes in BDNF expression and hyperactivity in inferior colliculus...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895941/midbrain-frequency-representation-following-moderately-intense-neonatal-sound-exposure-in-a-precocious-animal-model-chinchilla-laniger
#13
Lisa M D'Alessandro, Robert V Harrison
Auditory brain areas undergo reorganization resulting from abnormal sensory input during early postnatal development. This is evident from studies at the cortical level but it remains unclear whether there is reorganization in the auditory midbrain in a species similar to the human, that is, with early hearing onset. We have explored midbrain plasticity in the chinchilla, a precocious species that matches the human in terms of hearing development. Neonatal chinchillas were chronically exposed to a 2 kHz narrowband sound at 70 dB SPL for 4 weeks...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27891687/effect-of-preceding-stimulation-on-sound-localization-and-its-representation-in-the-auditory-midbrain
#14
Sandra Tolnai, Rainer Beutelmann, Georg M Klump
Prior stimulation can influence the perception of sound source location. Some psychophysical sound localization procedures differ in the amount of prior stimulation, which may affect measures of localization accuracy. If and how particularly the number of preceding stimuli affects sound localization and the neural representation of sound source position has not been investigated so far and will be the focus of the present report. We trained Mongolian gerbils in a left/right discrimination task where the target stimulus was preceded by silence or followed a number of reference stimuli...
November 27, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27891665/spectral-summation-and-facilitation-in-on-and-off-responses-for-optimized-representation-of-communication-calls-in-mouse-inferior-colliculus
#15
Alexander G Akimov, Marina A Egorova, Günter Ehret
Selectivity for processing of species-specific vocalizations and communication sounds has often been associated with the auditory cortex. The midbrain inferior colliculus, however, is the first center in the auditory pathways of mammals integrating acoustic information processed in separate nuclei and channels in the brainstem and, therefore, could significantly contribute to enhance the perception of species' communication sounds. Here, we used natural wriggling calls of mouse pups, which communicate need for maternal care to adult females, and further 15 synthesized sounds to test the hypothesis that neurons in the central nucleus of the inferior colliculus of adult females optimize their response rates for reproduction of the three main harmonics (formants) of wriggling calls...
November 27, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27891078/neural-and-response-correlations-to-complex-natural-sounds-in-the-auditory-midbrain
#16
Dominika Lyzwa, Florentin Wörgötter
How natural communication sounds are spatially represented across the inferior colliculus, the main center of convergence for auditory information in the midbrain, is not known. The neural representation of the acoustic stimuli results from the interplay of locally differing input and the organization of spectral and temporal neural preferences that change gradually across the nucleus. This raises the question of how similar the neural representation of the communication sounds is across these gradients of neural preferences, and whether it also changes gradually...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27832500/long-lasting-forward-suppression-of-spontaneous-firing-in-auditory-neurons-implication-to-the-residual-inhibition-of-tinnitus
#17
A V Galazyuk, S V Voytenko, R J Longenecker
Tinnitus is the perception of a sound that has no external source. Sound stimuli can suppress spontaneous firing in auditory neurons long after stimulus offset. It is unknown how changes in sound stimulus parameters affect this forward suppression. Using in vivo extracellular recording in awake mice, we found that about 40 % of spontaneously active inferior colliculus (IC) neurons exhibited forward suppression of spontaneous activity after sound offset. The duration of this suppression increased with sound duration and lasted about 40 s following a 30-s stimulus offset...
November 10, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27826232/variable-effects-of-acoustic-trauma-on-behavioral-and-neural-correlates-of-tinnitus-in-individual-animals
#18
Ryan J Longenecker, Alexander V Galazyuk
The etiology of tinnitus is known to be diverse in the human population. An appropriate animal model of tinnitus should incorporate this pathological diversity. Previous studies evaluating the effect of acoustic over exposure (AOE) have found that animals typically display increased spontaneous firing rates and bursting activity of auditory neurons, which often has been linked to behavioral evidence of tinnitus. However, only a subset of studies directly associated these neural correlates to individual animals...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27822756/the-time-scale-of-adaptation-in-tonal-sequence-processing-by-the-mouse-auditory-midbrain-neurons
#19
E S Malinina, M A Egorova, G D Khorunzhii, A G Akimov
The time course of poststimulatory adaptation of the inferior colliculus central nucleus (ICC) of CBB6F1 hybrid mice to sound sequences, specifically, series of four tonal stimuli presented at intervals of 0, 2, 4, 10, 20, 50, 100, 200, 500, 700, 1000, and 1500 ms were studied. Assessment of the adaptation of the entire neuronal population have shown that, at an interstimulus interval of 0-200 ms, the response to the first tone in a series is significantly stronger than those to the second to fourth tones, the strengths of the latter three responses not differing significantly from one another...
September 2016: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/27813207/ageing-affects-dual-encoding-of-periodicity-and-envelope-shape-in-rat-inferior-colliculus-neurons
#20
Björn Herrmann, Aravindakshan Parthasarathy, Edward L Bartlett
Extracting temporal periodicities and envelope shapes of sounds is important for listening within complex auditory scenes but declines behaviorally with age. Here, we recorded local field potentials (LFPs) and spikes to investigate how ageing affects the neural representations of different modulation rates and envelope shapes in the inferior colliculus of rats. We specifically aimed to explore the input-output (LFP-spike) response transformations of inferior colliculus neurons. Our results show that envelope shapes up to 256-Hz modulation rates are represented in the neural synchronisation phase lags in younger and older animals...
November 4, 2016: European Journal of Neuroscience
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