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https://www.readbyqxmd.com/read/29156225/differences-between-auditory-frequency-following-responses-and-onset-responses-intracranial-evidence-from-rat-inferior-colliculus
#1
Qian Wang, Liang Li
A periodic sound, such as a pure tone, evokes both transient onset field-potential responses and sustained frequency-following responses (FFRs) in the auditory midbrain, the inferior colliculus (IC). It is not clear whether the two types of responses are based on the same or different neural substrates. Although it has been assumed that FFRs are based on phase locking to the periodic sound, the evidence showing the direct relationship between the FFR amplitude and the phase-locking strength is still lacking...
November 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/29155767/a-wireless-bidirectional-interface-for-in-vivo-recording-and-stimulation-of-neural-activity-in-freely-behaving-rats
#2
Liana Melo-Thomas, K-Alexander Engelhardt, Uwe Thomas, Dirk Hoehl, Sascha Thomas, Markus Wöhr, Bjoern Werner, Frank Bremmer, Rainer K W Schwarting
In vivo electrophysiology is a powerful technique to investigate the relationship between brain activity and behavior at a millisecond and micrometer scale. However, current methods mostly rely on tethered cable recordings or only use unidirectional systems, allowing either recording or stimulation of neural activity, but not at the same time or same target. Here, a new wireless, bidirectional device for simultaneous multichannel recording and stimulation of neural activity in freely behaving rats is described...
November 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29143124/the-effect-of-inhibition-on-stimulus-specific-adaptation-in-the-inferior-colliculus
#3
Yaneri A Ayala, Manuel S Malmierca
The inferior colliculus is a center of convergence for inhibitory and excitatory synaptic inputs that may be activated simultaneously by sound stimulation. Stimulus repetition may generate response habituation by changing the efficacy of neuron's synaptic inputs. Specialized IC neurons reduce their response to repetitive tones, but restore their firing when a different and infrequent tone occurs, a phenomenon known as stimulus specific adaptation. Here, using the microiontophoresis technique, we determined the role of GABAA-, GABAB-, and glycinergic receptors in stimulus-specific adaptation (SSA)...
November 15, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29130968/immunohistochemical-localization-of-calbindin-d28k-parvalbumin-and-calretinin-in-the-superior-olivary-complex-of-circling-mice
#4
Jin-Koo Lee, Dhiraj Maskey, Myeung Ju Kim
The circling mouse serves as a hearing loss model. It has spontaneous tmie gene mutations that cause hair cell and cochlear degeneration. However, little is known about the role of the tmie gene in superior olivary complex (SOC) regions, in which sound information from the two ears is integrated and primarily relayed to the nuclei of the lateral lemniscus and inferior colliculus. Several studies have reported that abnormal calcium (Ca2+) homeostasis is associated with the pathology of hearing loss. This study investigated the distribution of Ca2+-binding proteins (CaBPs), such as calbindin D28k, parvalbumin, and calretinin, in the SOC of the circling mouse on postnatal day 16...
November 4, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29116453/the-role-of-the-pulvinar-in-spatial-visual-attention
#5
Ricardo Gattass, Juliana G M Soares, Bruss Lima
This chapter deals with the role of the pulvinar in spatial visual attention. There are at least two aspects in which the pulvinar seems to be instrumental for selective visual processes. The first aspect concerns pulvinar connectivity pattern. The pulvinar is connected with brain regions known to be playing a role in attentional mechanisms, such as area V4, the superior colliculus (SC), and the inferior parietal cortex (IP). Additionally, the pulvinar is richly interconnected with multiple cortical areas. This enables the pulvinar to serve as a hub for brain communication, potentially gating the flow of information across different regions...
2018: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/29112481/diffusion-tensor-imaging-of-central-auditory-pathways-in-patients-with-sensorineural-hearing-loss-a-systematic-review
#6
Osama Tarabichi, Elliott D Kozin, Vivek V Kanumuri, Samuel Barber, Satra Ghosh, Kevin R Sitek, Katherine Reinshagen, Barbara Herrmann, Aaron K Remenschneider, Daniel J Lee
Objective The radiologic evaluation of patients with hearing loss includes computed tomography and magnetic resonance imaging (MRI) to highlight temporal bone and cochlear nerve anatomy. The central auditory pathways are often not studied for routine clinical evaluation. Diffusion tensor imaging (DTI) is an emerging MRI-based modality that can reveal microstructural changes in white matter. In this systematic review, we summarize the value of DTI in the detection of structural changes of the central auditory pathways in patients with sensorineural hearing loss...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29101749/analysis-of-erk1-2-kinases-in-the-inferior-colliculus-of-rats-genetically-prone-to-audiogenic-seizures-during-postnatal-development
#7
E V Chernigovskaya, O O Lebedenko, A V Nidenfyur, L S Nikitina, M V Glazova
The activity of ERK1/2 kinases in the quadrigemina inferior colliculus of Krushinsky-Molodkina rats of different age, which are characterized by an increased seizure readiness compared to Wistar rats, was analyzed. An increased (probably genetically determined) activity of these enzymes during the development of epileptiform activity in ontogeny was found, which may be the cause of abnormalities in the neurotransmitter system functioning.
September 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29071963/-effect-of-electroacupuncture-on-expression-of-catechol-o-methyltransferase-in-the-inferior-colliculus-and-auditory-cortex-in-age-related-hearing-loss-guinea-pigs
#8
Shu-Yun Liu, Li-Qiang Deng, Ye Yang, Ze-Deng Yin
OBJECTIVE: To observe the expression of catechol-O-methyltransferase (COMT) in inferior colliculus and auditory cortex of guinea pigs with age-related hearing loss(AHL) induced by D-galactose, so as to explore the possible mechanism of electroacupuncture(EA) underlying preventing AHL. METHODS: Thirty 3-month-old guinea pigs were randomly divided into control group, model group and EA group(n=10 in each group), and ten 18-month-old guinea pigs were allocated as elderly group...
April 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29069619/breakdown-of-excitability-by-attenuated-prv-152-infection-in-auditory-brainstem-neurons-of-mongolian-gerbils
#9
Christian P Porres, Benedikt Grothe, Felix Felmy
Pseudorabies virus (PRV), a neurovirulent α-herpesvirus, spreads between neurons at synaptic connections. PRV-infected neurons have been shown to exhibit functional deficits with the attenuated PRV152 Bartha strain negatively influencing neuronal functioning in in vitro model systems. However, the impact of this attenuated PRV152 Bartha strain on the native central nervous system has not been fully explored. Using a combination of in vivo stereotactic injections and post-hoc in vitro whole-cell recordings, we investigated the functional impact of PRV152 Bartha in the auditory system of juvenile Mongolian gerbils...
October 22, 2017: Neuroscience
https://www.readbyqxmd.com/read/29061702/presynaptic-neuronal-nicotinic-receptors-differentially-shape-select-inputs-to-auditory-thalamus-and-are-negatively-impacted-by-aging
#10
Sarah Y Sottile, Troy A Hackett, Rui Cai, Lynne Ling, Daniel A Llano, Donald M Caspary
Acetylcholine is a potent neuromodulator capable of modifying patterns of acoustic information flow. In auditory cortex, cholinergic systems have been shown to increase salience/gain while suppressing extraneous information. However, the mechanism by which cholinergic circuits shape signal processing in the auditory thalamus (medial geniculate body, MGB) is poorly understood. The present study, in male Fischer Brown Norway rats, seeks to determine the location and function of presynaptic neuronal nicotinic acetylcholine receptors (nAChRs) at the major inputs to MGB and characterize how nAChRs change during aging...
October 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29060273/auditory-responses-to-short-wavelength-infrared-neural-stimulation-of-the-rat-cochlear-nucleus
#11
Bin Jiang, Nan Xia, Xing Wang, Ning Hu, Xiao Y Wu, Yi Zhou, Wen S Hou
Pulsed Infrared laser is well-known for its high spatial resolution and contact-free stimulation mode. In order to improve the current auditory brainstem implants (ABI), 980 nm-short-wavelength infrared light was applied to stimulate the cochlear nucleus of rats. Single neural activity from contralateral inferior colliculus was recorded during laser stimulation. Animal experimental results showed that 980 nm laser could not directly activate neurons in cochlear nucleus and a photo-acoustic response was observed during stimulation, however, 980 nm laser produces an inhibitory effect on neural responses to sounds; After we added carbon nanoparticles onto the surface of animal cochlear nucleus, 980 nm laser could directly stimulate neurons and no interference between adjacent recording channels was observed...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29050909/bold-fmri-in-the-mouse-auditory-pathway
#12
Guilherme Blazquez Freches, Cristina Chavarrias, Noam Shemesh
The auditory pathway is widely distributed throughout the brain, and is perhaps one of the most interesting networks in the context of neuroplasticity. Accurate mapping of neural activity in the entire pathway, preferably noninvasively, and with high resolution, could be instrumental for understanding such longitudinal processes. Functional magnetic resonance imaging (fMRI) has clear advantages for such characterizations, as it is noninvasive, provides relatively high spatial resolution and lends itself for repetitive studies, albeit relying on an indirect neurovascular coupling to deliver its information...
October 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/29043102/the-distribution-of-calbindin-d28k-parvalbumin-and-calretinin-immunoreactivity-in-the-inferior-colliculus-of-circling-mouse
#13
Jin-Koo Lee, Myeung Ju Kim
The circling mice with tmie gene mutation are known as an animal deafness model, which showed hyperactive circling movement. Recently, the reinvestigation of circling mouse was performed to check the inner ear pathology as a main lesion of early hearing loss. In this trial, the inner ear organs were not so damaged to cause the hearing deficit of circling (cir/cir) mouse at 18 postnatal day (P18) though auditory brainstem response data indicated hearing loss of cir/cir mice at P18. Thus, another mechanism may be correlated with the early hearing loss of cir/cir mice at P18...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042580/distorting-temporal-fine-structure-by-phase-shifting-and-its-effects-on-speech-intelligibility-and-neural-phase-locking
#14
Yingyue Xu, Maxin Chen, Petrina LaFaire, Xiaodong Tan, Claus-Peter Richter
Envelope (E) and temporal fine structure (TFS) are important features of acoustic signals and their corresponding perceptual function has been investigated with various listening tasks. To further understand the underlying neural processing of TFS, experiments in humans and animals were conducted to demonstrate the effects of modifying the TFS in natural speech sentences on both speech recognition and neural coding. The TFS of natural speech sentences was modified by distorting the phase and maintaining the magnitude...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29031607/hearing-without-neuroglobin
#15
Manuela Nowotny, Lenneke Kiefer, Daniel Andre, Andrej Fabrizius, Thomas Hankeln, Stefan Reuss
Neuroglobin (Ngb) is a member of the globin family of respiratory proteins, which was recently observed in many neurons of the auditory pathways. Up to now, however, nothing was known about the role of Ngb in hearing processes. We therefore studied auditory function by recording distortion-product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABRs) in wild-type (C57BL/6N) and Ngb-knockout mice. In KO mice, DPOAE thresholds were moderately augmented in the range of 5-18 kHz, reaching statistical significance at 8 and 10 kHz, while the ABR thresholds were not different between groups...
October 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/29018625/hearing-assessment-during-deep-brain-stimulation-of-the-central-nucleus-of-the-inferior-colliculus-and-dentate-cerebellar-nucleus-in-rat
#16
Jasper V Smit, Ali Jahanshahi, Marcus L F Janssen, Robert J Stokroos, Yasin Temel
BACKGROUND: Recently it has been shown in animal studies that deep brain stimulation (DBS) of auditory structures was able to reduce tinnitus-like behavior. However, the question arises whether hearing might be impaired when interfering in auditory-related network loops with DBS. METHODS: The auditory brainstem response (ABR) was measured in rats during high frequency stimulation (HFS) and low frequency stimulation (LFS) in the central nucleus of the inferior colliculus (CIC, n = 5) or dentate cerebellar nucleus (DCBN, n = 5)...
2017: PeerJ
https://www.readbyqxmd.com/read/28985384/putting-it-in-context-linking-auditory-processing-with-social-behavior-circuits-in-the-vertebrate-brain
#17
Christopher L Petersen, Laura M Hurley
Context is critical to the adaptive value of communication. Sensory systems such as the auditory system represent an important juncture at which information on physiological state or social valence can be added to communicative information. However, the neural pathways that convey context to the auditory system are not well understood. The serotonergic system offers an excellent model to address these types of questions. Serotonin fluctuates in the mouse inferior colliculus (IC), an auditory midbrain region important for species-specific vocalizations, during specific social and non-social contexts...
July 27, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28943120/diversity-of-bilateral-synaptic-assemblies-for-binaural-computation-in-midbrain-single-neurons
#18
Na He, Lingzhi Kong, Tao Lin, Shaohui Wang, Xiuping Liu, Jiyao Qi, Jun Yan
Binaural hearing confers many beneficial functions but our understanding of its underlying neural substrates is limited. This study examines the bilateral synaptic assemblies and binaural computation (or integration) in the central nucleus of the inferior colliculus (ICc) of the auditory midbrain, a key convergent center. Using in-vivo whole-cell patch-clamp, the excitatory and inhibitory postsynaptic potentials (EPSPs/IPSPs) of single ICc neurons to contralateral, ipsilateral and bilateral stimulation were recorded...
September 18, 2017: Hearing Research
https://www.readbyqxmd.com/read/28918463/apoptotic-mechanisms-after-repeated-noise-trauma-in-the-mouse-medial-geniculate-body-and-primary-auditory-cortex
#19
Felix Fröhlich, Arne Ernst, Ira Strübing, Dietmar Basta, Moritz Gröschel
A correlation between noise-induced apoptosis and cell loss has previously been shown after a single noise exposure in the cochlear nucleus, inferior colliculus, medial geniculate body (MGB) and primary auditory cortex (AI). However, repeated noise exposure is the most common situation in humans and a major risk factor for the induction of noise-induced hearing loss (NIHL). The present investigation measured cell death pathways using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) in the dorsal, medial and ventral MGB (dMGB, mMGB and vMGB) and six layers of the AI (AI-1 to AI-6) in mice (NMRI strain) after a second noise exposure (double-exposure group)...
December 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28878630/temporal-expression-of-wnt1-defines-the-competency-state-and-terminal-identity-of-progenitors-in-the-developing-cochlear-nucleus-and-inferior-colliculus
#20
Stephen Brown, Mark Zervas
The auditory system contains a diverse array of interconnected anatomical structures that mediate the perception of sound. The cochlear nucleus of the hindbrain serves as the initial site of convergence for auditory stimuli, while the inferior colliculus of the midbrain serves as an integration and relay station for all ascending auditory information. We used Genetic Inducible Fate Mapping (GIFM) to determine how the timing of Wnt1 expression is related to the competency states of auditory neuron progenitors...
2017: Frontiers in Neuroanatomy
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