keyword
https://read.qxmd.com/read/38514192/the-mouse-inferior-colliculus-responds-preferentially-to-non-ultrasonic-vocalizations
#1
JOURNAL ARTICLE
Mahtab Tehrani, Sharad Shanbhag, Julia J Huyck, Rahi Patel, Diana Kazimiersky, Jeffrey J Wenstrup
The inferior colliculus (IC), the midbrain auditory integration center, analyzes information about social vocalizations and provides substrates for higher level processing of vocal signals. We used multi-channel recordings to characterize and localize responses to social vocalizations and synthetic stimuli within the IC of female and male mice, both urethane-anesthetized and unanesthetized. We compared responses to ultrasonic vocalizations (USVs) with other vocalizations in the mouse repertoire and related vocal responses to frequency tuning, IC subdivisions, and sex...
March 21, 2024: ENeuro
https://read.qxmd.com/read/38505907/population-coding-of-time-varying-sounds-in-the-non-lemniscal-inferior-colliculus
#2
JOURNAL ARTICLE
Kaiwen Shi, Gunnar L Quass, Meike M Rogalla, Alexander N Ford, Jordyn E Czarny, Pierre F Apostolides
The inferior colliculus (IC) of the midbrain is important for complex sound processing, such as discriminating conspecific vocalizations and human speech. The IC's non-lemniscal, dorsal "shell" region is likely important for this process, as neurons in these layers project to higher-order thalamic nuclei that subsequently funnel acoustic signals to the amygdala and non-primary auditory cortices; forebrain circuits important for vocalization coding in a variety of mammals, including humans. However, the extent to which shell IC neurons transmit acoustic features necessary to discern vocalizations is less clear, owing to the technical difficulty of recording from neurons in the IC's superficial layers via traditional approaches...
March 20, 2024: Journal of Neurophysiology
https://read.qxmd.com/read/38496510/the-auditory-midbrain-mediates-tactile-vibration-sensing
#3
Erica L Huey, Josef Turecek, Michelle M Delisle, Ofer Mazor, Gabriel E Romero, Malvika Dua, Zoe K Sarafis, Alexis Hobble, Kevin T Booth, Lisa V Goodrich, David P Corey, David D Ginty
Vibrations are ubiquitous in nature, shaping behavior across the animal kingdom. For mammals, sound waves traveling through air are captured by the cochlea and the neural signals they generate are encoded in the auditory system 1 . Mechanical vibrations acting on the body are detected by mechanoreceptors of the skin and deep tissue and processed by the somatosensory system 2 . As such, the neural pathways that underlie perception and reaction to sound waves and mechanical vibrations are believed to be anatomically distinct and functionally independent...
March 8, 2024: bioRxiv
https://read.qxmd.com/read/38492568/sound-elicits-stereotyped-facial-movements-that-provide-a-sensitive-index-of-hearing-abilities-in-mice
#4
JOURNAL ARTICLE
Kameron K Clayton, Kamryn S Stecyk, Anna A Guo, Anna R Chambers, Ke Chen, Kenneth E Hancock, Daniel B Polley
Sound elicits rapid movements of muscles in the face, ears, and eyes that protect the body from injury and trigger brain-wide internal state changes. Here, we performed quantitative facial videography from mice resting atop a piezoelectric force plate and observed that broadband sounds elicited rapid and stereotyped facial twitches. Facial motion energy (FME) adjacent to the whisker array was 30 dB more sensitive than the acoustic startle reflex and offered greater inter-trial and inter-animal reliability than sound-evoked pupil dilations or movement of other facial and body regions...
March 6, 2024: Current Biology: CB
https://read.qxmd.com/read/38392310/can-extensive-training-transform-a-mouse-into-a-guinea-pig-an-evaluation-based-on-the-discriminative-abilities-of-inferior-colliculus-neurons
#5
JOURNAL ARTICLE
Alexandra Martin, Samira Souffi, Chloé Huetz, Jean-Marc Edeline
Humans and animals maintain accurate discrimination between communication sounds in the presence of loud sources of background noise. In previous studies performed in anesthetized guinea pigs, we showed that, in the auditory pathway, the highest discriminative abilities between conspecific vocalizations were found in the inferior colliculus. Here, we trained CBA/J mice in a Go/No-Go task to discriminate between two similar guinea pig whistles, first in quiet conditions, then in two types of noise, a stationary noise and a chorus noise at three SNRs...
February 2, 2024: Biology
https://read.qxmd.com/read/38370776/the-mouse-inferior-colliculus-responds-preferentially-to-non-ultrasonic-vocalizations
#6
Mahtab Tehrani, Sharad Shanbhag, Julia J Huyck, Rahi Patel, Diana Kazimiersky, Jeffrey J Wenstrup
UNLABELLED: The inferior colliculus (IC), the midbrain auditory integration center, analyzes information about social vocalizations and provides substrates for higher level processing of vocal signals. We used multi-channel recordings to characterize and localize responses to social vocalizations and synthetic stimuli within the IC of female and male mice, both urethane-anesthetized and unanesthetized. We compared responses to ultrasonic vocalizations (USVs) with other vocalizations in the mouse repertoire and related vocal responses to frequency tuning, IC subdivisions, and sex...
February 11, 2024: bioRxiv
https://read.qxmd.com/read/38361295/microstructural-changes-in-the-brainstem-auditory-pathway-in-children-with-hearing-loss
#7
JOURNAL ARTICLE
Peter K Moon, Kristina M Ward, Taseer F Din, Sara Saki, Alan G Cheng, Kristen W Yeom, Iram N Ahmad
OBJECTIVE: To assess the utility of diffusion tensor imaging of the auditory pathway in children with sensorineural hearing loss (SNHL). STUDY DESIGN: Retrospective cohort study. SETTING: A single academic tertiary children's hospital. PATIENTS: Sixteen pediatric patients with bilateral SNHL of at least moderate severity in the poorer ear (eight male; mean age, 5.3 ± 4.9 yrs). Controls consisted of age- and sex-matched children with normal hearing who were imaged for nonotologic, non-neurologic medical concerns and found to have normal magnetic resonance imaging (MRI)...
March 1, 2024: Otology & Neurotology
https://read.qxmd.com/read/38360566/harmony-in-the-molecular-orchestra-of-hearing-developmental-mechanisms-from-the-ear-to-the-brain
#8
REVIEW
Sonja J Pyott, Gabriela Pavlinkova, Ebenezer N Yamoah, Bernd Fritzsch
Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing...
February 15, 2024: Annual Review of Neuroscience
https://read.qxmd.com/read/38344749/-dbx1-is-a-dorsal-midbrain-specific-determinant-of-gabaergic-neuron-fate-and-regulates-differentiation-of-the-dorsal-midbrain-into-the-inferior-and-superior-colliculi
#9
JOURNAL ARTICLE
Hong-Nhung Tran, Quy-Hoai Nguyen, Yongsu Jeong
The mechanism underlying the differentiation of the dorsal midbrain into two morphologically and functionally distinct compartments, the inferior colliculus (IC) and superior colliculus (SC), which process auditory and visual information, respectively, remains largely unexplored. By using null and conditional alleles, we uncover the roles of a homeodomain transcription factor Dbx1 in the regulation of IC and SC differentiation. We show that Dbx1 regulates GABAergic neuron development in the dorsal midbrain...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38326037/parvalbumin-and-somatostatin-biomarkers-for-two-parallel-tectothalamic-pathways-in-the-auditory-midbrain
#10
JOURNAL ARTICLE
Mengting Liu, Yixiao Gao, Fengyuan Xin, Ying Hu, Tao Wang, Fenghua Xie, Chengjun Shao, Tianyu Li, Ningyu Wang, Kexin Yuan
The inferior colliculus (IC) represents a crucial relay station in the auditory pathway, located in the midbrain's tectum and primarily projecting to the thalamus. Despite the identification of distinct cell classes based on various biomarkers in the IC, their specific contributions to the organization of auditory tectothalamic pathways have remained poorly understood. In this study, we demonstrate that IC neurons expressing parvalbumin (ICPV+ ) or somatostatin (ICSOM+ ) represent two minimally overlapping cell classes throughout the three IC subdivisions in mice of both sexes...
February 7, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38308936/how-hidden-hearing-loss-noise-exposure-affects-neural-coding-in-the-inferior-colliculus-of-rats
#11
JOURNAL ARTICLE
Warren M H Bakay, Blanca Cervantes, Ana B Lao-Rodríguez, Peter T Johannesen, Enrique A Lopez-Poveda, David N Furness, Manuel S Malmierca
Exposure to brief, intense sound can produce profound changes in the auditory system, from the internal structure of inner hair cells to reduced synaptic connections between the auditory nerves and the inner hair cells. Moreover, noisy environments can also lead to alterations in the auditory nerve or to processing changes in the auditory midbrain, all without affecting hearing thresholds. This so-called hidden hearing loss (HHL) has been shown in tinnitus patients and has been posited to account for hearing difficulties in noisy environments...
January 21, 2024: Hearing Research
https://read.qxmd.com/read/38267259/dissociable-roles-of-the-auditory-midbrain-and-cortex-in-processing-the-statistical-features-of-natural-sound-textures
#12
JOURNAL ARTICLE
Fei Peng, Nicol S Harper, Ambika Prasad Mishra, Ryszard Auksztulewicz, Jan W H Schnupp
Sound texture perception takes advantage of a hierarchy of time-averaged statistical features of acoustic stimuli, but much remains unclear about how these statistical features are processed along the auditory pathway. Here, we compared the neural representation of sound textures in the inferior colliculus (IC) and auditory cortex (AC) of anesthetized female rats. We recorded responses to texture morph stimuli which gradually add statistical features of increasingly higher complexity. For each texture, several different exemplars were synthesized using different random seeds...
January 24, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38244755/research-progress-of-the-inferior-colliculus-from-neuron-neural-circuit-to-auditory-disease
#13
JOURNAL ARTICLE
Mengting Liu, Yuyao Wang, Li Jiang, Xiaopeng Zhang, Chunrui Wang, Tianhong Zhang
The auditory midbrain, also known as the inferior colliculus (IC), serves as a crucial hub in the auditory pathway. Comprising diverse cell types, the IC plays a pivotal role in various auditory functions, including sound localization, auditory plasticity, sound detection, and sound-induced behaviors. Notably, the IC is implicated in several auditory central disorders, such as tinnitus, age-related hearing loss, autism and Fragile X syndrome. Accurate classification of IC neurons is vital for comprehending both normal and dysfunctional aspects of IC function...
January 18, 2024: Brain Research
https://read.qxmd.com/read/38242692/disynaptic-inhibitory-cerebellar-control-over-caudal-medial-accessory-olive
#14
JOURNAL ARTICLE
Willem S van Hoogstraten, Marit C C Lute, Zhiqiang Liu, Robin Broersen, Luca Mangili, Lieke Kros, Zhenyu Gao, Xiaolu Wang, Arn M J M van den Maagdenberg, Chris I De Zeeuw
The olivocerebellar system, which is critical for sensorimotor performance and learning, functions through modules with feedback loops. The main feedback to the inferior olive comes from the cerebellar nuclei (CN), which are predominantly GABAergic and contralateral. However, for the d subnucleus of the caudomedial accessory olive (cdMAO), a crucial region for oculomotor and upper-body movements, the source of GABAergic input has yet to be identified. Here, we demonstrate the existence of a disynaptic inhibitory projection from the medial CN (MCN) to the cdMAO via the superior colliculus (SC) by exploiting retrograde, anterograde and transsynaptic viral tracing at the light microscopic level as well as anterograde classical and viral tracing combined with immunocytochemistry at the electron microscopic level...
January 19, 2024: ENeuro
https://read.qxmd.com/read/38240754/the-superior-colliculus-projection-upon-the-macaque-inferior-olive
#15
JOURNAL ARTICLE
Paul J May, Susan Warren, Yoshiko Kojima
Saccade accommodation is a productive model for exploring the role of the cerebellum in behavioral plasticity. In this model, the target is moved during the saccade, gradually inducing a change in the saccade vector as the animal adapts. The climbing fiber pathway from the inferior olive provides a visual error signal generated by the superior colliculus that is believed to be crucial for cerebellar adaptation. However, the primate tecto-olivary pathway has only been explored using large injections of the central portion of the superior colliculus...
January 19, 2024: Brain Structure & Function
https://read.qxmd.com/read/38219615/time-dependent-effects-of-acoustic-trauma-and-tinnitus-on-extracellular-levels-of-amino-acids-in-the-inferior-colliculus-of-rats
#16
JOURNAL ARTICLE
Huey Tieng Tan, Paul F Smith, Yiwen Zheng
Chronic tinnitus is a debilitating condition with very few management options. Acoustic trauma that causes tinnitus has been shown to induce neuronal hyperactivity in multiple brain areas in the auditory pathway, including the inferior colliculus. This neuronal hyperactivity could be attributed to an imbalance between excitatory and inhibitory neurotransmission. However, it is not clear how the levels of neurotransmitters, especially neurotransmitters in the extracellular space, change over time following acoustic trauma and the development of tinnitus...
January 3, 2024: Hearing Research
https://read.qxmd.com/read/38184639/an-rna-seq-atlas-of-mouse-brain-areas-during-fasting-and-diet-induced-obesity
#17
JOURNAL ARTICLE
Petar V Todorov, Anders Bue Klein, Kristoffer L Egerod, Christoffer Clemmensen, Tune H Pers
Mammalian energy homeostasis is primarilly regulated by the hypothalamus and hindbrain, with the hippocampus, midbrain nuclei, and other regions implicated by evidence from human genetics studies. To understand how these non-canonical brain regions respond to imbalances in energy homeostasis, we performed two experiments examining the effects of different diets in male C57BL6 mice. In our first study, groups of six pair-housed mice were given access to chow, high-fat diet or fasted for 16 hours...
January 6, 2024: Scientific Data
https://read.qxmd.com/read/38170771/sequential-maturation-of-stimulus-specific-adaptation-in-the-mouse-lemniscal-auditory-system
#18
JOURNAL ARTICLE
Patricia Valerio, Julien Rechenmann, Suyash Joshi, Gioia De Franceschi, Tania Rinaldi Barkat
Stimulus-specific adaptation (SSA), the reduction of neural activity to a common stimulus that does not generalize to other, rare stimuli, is an essential property of our brain. Although well characterized in adults, it is still unknown how it develops during adolescence and what neuronal circuits are involved. Using in vivo electrophysiology and optogenetics in the lemniscal pathway of the mouse auditory system, we observed SSA to be stable from postnatal day 20 (P20) in the inferior colliculus, to develop until P30 in the auditory thalamus and even later in the primary auditory cortex (A1)...
January 5, 2024: Science Advances
https://read.qxmd.com/read/38166599/degraded-inferior-colliculus-responses-to-complex-sounds-in-prenatally-exposed-vpa-rats
#19
JOURNAL ARTICLE
Yuko Tamaoki, Varun Pasapula, Collin Chandler, Michael S Borland, Olayinka I Olajubutu, Liza S Tharakan, Crystal T Engineer
BACKGROUND: Individuals with autism spectrum disorders (ASD) often exhibit altered sensory processing and deficits in language development. Prenatal exposure to valproic acid (VPA) increases the risk for ASD and impairs both receptive and expressive language. Like individuals with ASD, rodents prenatally exposed to VPA exhibit degraded auditory cortical processing and abnormal neural activity to sounds. Disrupted neuronal morphology has been documented in earlier processing areas of the auditory pathway in VPA-exposed rodents, but there are no studies documenting early auditory pathway physiology...
January 2, 2024: Journal of Neurodevelopmental Disorders
https://read.qxmd.com/read/38157437/comprehensive-analysis-of-the-spatial-distribution-of-gadolinium-iron-manganese-and-phosphorus-in-the-brain-of-healthy-rats-after-high-dose-administrations-of-gadodiamide-and-gadobutrol
#20
JOURNAL ARTICLE
Luis Hummel, Thomas Frenzel, Janina Boyken, Hubertus Pietsch, Erdmann Seeliger
OBJECTIVES: After the administration of gadolinium-based contrast agents (GBCAs), residual gadolinium (Gd) has been detected in a few distinct morphological structures of the central nervous system (CNS). However, a systematic, comprehensive, and quantitative analysis of the spatial Gd distribution in the entire brain is not yet available. The first aim of this study is to provide this analysis in healthy rats after administration of high GBCA doses. The second aim is to assess the spatial distributions and possible Gd colocalizations of endogenous iron (Fe), manganese (Mn), and phosphorus (P)...
December 28, 2023: Investigative Radiology
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