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https://www.readbyqxmd.com/read/28334187/individual-differences-in-human-auditory-processing-insights-from-single-trial-auditory-midbrain-activity-in-an-animal-model
#1
Travis White-Schwoch, Trent Nicol, Catherine M Warrier, Daniel A Abrams, Nina Kraus
Auditory-evoked potentials are classically defined as the summations of synchronous firing along the auditory neuraxis. Converging evidence supports a model whereby timing jitter in neural coding compromises listening and causes variable scalp-recorded potentials. Yet the intrinsic noise of human scalp recordings precludes a full understanding of the biological origins of individual differences in listening skills. To delineate the mechanisms contributing to these phenomena, in vivo extracellular activity was recorded from inferior colliculus in guinea pigs to speech in quiet and noise...
October 5, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/28283747/magnetic-resonance-diffusion-tensor-imaging-for-the-pedunculopontine-nucleus-proof-of-concept-and-histological-correlation
#2
A T D L Alho, C Hamani, E J L Alho, R E da Silva, G A B Santos, R C Neves, L L Carreira, C M M Araújo, G Magalhães, D B Coelho, M C Alegro, M G M Martin, L T Grinberg, C A Pasqualucci, H Heinsen, E T Fonoff, E Amaro
The pedunculopontine nucleus (PPN) has been proposed as target for deep brain stimulation (DBS) in patients with postural instability and gait disorders due to its involvement in muscle tonus adjustments and control of locomotion. However, it is a deep-seated brainstem nucleus without clear imaging or electrophysiological markers. Some studies suggested that diffusion tensor imaging (DTI) may help guiding electrode placement in the PPN by showing the surrounding fiber bundles, but none have provided a direct histological correlation...
March 10, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28275059/differences-in-post-injury-auditory-system-pathophysiology-after-mild-blast-and-non-blast-acute-acoustic-trauma
#3
Nicholas Race, Jesyin Lai, Riyi Shi, Edward L Bartlett
Hearing difficulties are the most commonly reported disabilities among veterans. Blast exposures during explosive events likely play a role, given their propensity to directly damage both peripheral (PAS) and central (CAS) auditory system components. Post-blast PAS pathophysiology has been well-documented in both clinical case reports and laboratory investigations. In contrast, blast-induced CAS dysfunction remains under-studied, but has been hypothesized to contribute to an array of common veteran behavioral complaints including learning, memory, communication, and emotional regulation...
March 8, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28270764/does-chronic-tinnitus-alter-the-emotional-response-function-of-the-amygdala-a-sound-evoked-fmri-study
#4
Jeff E Davies, Phillip E Gander, Deborah A Hall
Tinnitus is often associated with strong negative thoughts and emotions which can contribute to a distressing and chronic long-term condition. The amygdala, the "feeling and reacting" part of the brain, may play a key role in this process. Although implicated in several theoretical models of tinnitus, quantification of activity in the human amygdala has only been made possible more recently through neuroimaging methods such as functional magnetic resonance imaging (fMRI) but benefits from modified scanning parameters using a double-echo acquisition for improved BOLD sensitivity...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28268636/neural-representation-of-different-mandarin-tones-in-the-inferior-colliculus-of-the-guinea-pig
#5
Fei Peng, Nan Xia, Xing Wang, Xiao L Zheng, Yi Zhou, Xing Y Fan, Wen S Hou
Mandarin speech has four different tones and the coding mechanism underlying tone identification still remain unclear. Here in the inferior colliculus (IC) of anesthetized guinea pigs, we recorded single neuron activities to one word with four tones using tungsten electrode. Peri-stimulus time histograms (PSTHs) and inter-spike-interval (ISI) were used to evaluate the neural response. The results showed that PSTHs grouped into frequency band reflected the spectrotemporal patterns of different tones; average population PSTHs matched envelops of different tones; and the peaks of histogram of ISIs in three time segments exhibited a displacement which reflected the profile of fundamental frequency (F0)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258282/evaluation-of-auditory-pathways-using-dti-in-patients-treated-with-gamma-knife-radiosurgery-for-acoustic-neuroma-a%C3%A2-preliminary-report
#6
Serpil Kurtcan, Mustafa Aziz Hatiboglu, Alpay Alkan, Huseyin Toprak, Mehmet Hakan Seyithanoglu, Ayse Aralasmak, Bahar Atasoy, Omer Uysal
PURPOSE: We aimed to evaluate the change in bilateral auditory pathways using diffusion tensor imaging (DTI) after gamma knife radiosurgery (GKR) and to determine the relationship between the radiosurgical treatment variables and DTI findings. METHODS: In this study 13 patients with unilateral acoustic neuroma and 11 controls underwent routine magnetic resonance imaging (MRI) and DTI. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured from the bilateral auditory pathways in all individuals before and after GKR...
March 3, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28226816/neural-representation-of-different-mandarin-tones-in-the-inferior-colliculus-of-the-guinea-pig
#7
Fei Peng, Nan Xia, Xing Wang, Xiao L Zheng, Yi Zhou, Xing Y Fan, Wen S Hou, Fei Peng, Nan Xia, Xing Wang, Xiao L Zheng, Yi Zhou, Xing Y Fan, Wen S Hou, Xing Y Fan, Nan Xia, Wen S Hou, Xing Wang, Yi Zhou, Fei Peng, Xiao L Zheng
Mandarin speech has four different tones and the coding mechanism underlying tone identification still remain unclear. Here in the inferior colliculus (IC) of anesthetized guinea pigs, we recorded single neuron activities to one word with four tones using tungsten electrode. Peri-stimulus time histograms (PSTHs) and inter-spike-interval (ISI) were used to evaluate the neural response. The results showed that PSTHs grouped into frequency band reflected the spectrotemporal patterns of different tones; average population PSTHs matched envelops of different tones; and the peaks of histogram of ISIs in three time segments exhibited a displacement which reflected the profile of fundamental frequency (F0)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221990/an-integrated-circuit-for-simultaneous-extracellular-electrophysiology-recording-and-optogenetic-neural-manipulation
#8
Chang Hao Chen, Elizabeth A McCullagh, Sio Hang Pun, Peng Un Mak, Mang I Vai, Pui In Mak, Achim Klug, Tim C Lei
OBJECTIVE: The ability to record and to control action potential firing in neuronal circuits is critical to understand how the brain functions. The objective of this study is to develop a monolithic integrated circuit (IC) to record action potentials and simultaneously control action potential firing using optogenetics. METHODS: A low-noise and high input impedance (or low input capacitance) neural recording amplifier is combined with a high current laser/light-emitting diode (LED) driver in a single IC...
March 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28202410/atypical-antipsychotic-clozapine-reversed-deficit-on-prepulse-inhibition-of-the-acoustic-startle-reflex-produced-by-microinjection-of-doi-into-the-inferior-colliculus-in-rats
#9
Rodolpho Pereira de Oliveira, Karen Yuriko Nagaishi, Regina Cláudia Barbosa Silva
Dysfunctions of the serotonergic system have been suggested to be important in the neurobiology of schizophrenia. Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. PPI is the normal reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus (pulse). The hallucinogen 2,5-dimethoxy-4-iodoamphetamine (DOI), a 5-hydroxytryptamine(HT)2 receptor agonist disrupted PPI in rats...
February 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28195225/a-novel-bk-channel-targeted-peptide-suppresses-sound-evoked-activity-in-the-mouse-inferior-colliculus
#10
L L Scott, E J Brecht, A Philpo, S Iyer, N S Wu, S J Mihic, R W Aldrich, J Pierce, J P Walton
Large conductance calcium-activated (BK) channels are broadly expressed in neurons and muscle where they modulate cellular activity. Decades of research support an interest in pharmaceutical applications for modulating BK channel function. Here we report a novel BK channel-targeted peptide with functional activity in vitro and in vivo. This 9-amino acid peptide, LS3, has a unique action, suppressing channel gating rather than blocking the pore of heterologously expressed human BK channels. With an IC50 in the high picomolar range, the apparent affinity is higher than known high affinity BK channel toxins...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28188855/auditory-processing-assessment-suggests-that-wistar-audiogenic-rat-neural-networks-are-prone-to-entrainment
#11
Hyorrana Priscila Pereira Pinto, Vinícius Rezende Carvalho, Daniel de Castro Medeiros, Ana Flávia Santos Almeida, Eduardo Mazoni Andrade Marçal Mendes, Márcio Flávio Dutra Moraes
Epilepsy is a neurological disease related to the occurrence of pathological oscillatory activity, but the basic physiological mechanisms of seizure remain to be understood. Our working hypothesis is that specific sensory processing circuits may present abnormally enhanced predisposition for coordinated firing in the dysfunctional brain. Such facilitated entrainment could share a similar mechanistic process as those expediting the propagation of epileptiform activity throughout the brain. To test this hypothesis, we employed the Wistar audiogenic rat (WAR) reflex animal model, which is characterized by having seizures triggered reliably by sound...
April 7, 2017: Neuroscience
https://www.readbyqxmd.com/read/28137699/frequency-dependent-fine-structure-in-the-frequency-following-response-the-byproduct-of-multiple-generators
#12
Parker Tichko, Erika Skoe
The frequency-following response (FFR) is an auditory-evoked response recorded at the scalp that captures the spectrotemporal properties of tonal stimuli. Previous investigations report that the amplitude of the FFR fluctuates as a function of stimulus frequency, a phenomenon thought to reflect multiple neural generators phase-locking to the stimulus with different response latencies. When phase-locked responses are offset by different latencies, constructive and destructive phase interferences emerge in the volume-conducted signals, culminating in an attenuation or amplification of the scalp-recorded response in a frequency-specific manner...
January 27, 2017: Hearing Research
https://www.readbyqxmd.com/read/28121979/protective-effects-of-acupuncture-against-gentamicin-induced-ototoxicity-in-rats-possible-role-of-neurotrophin-3
#13
Ping Zhou, Weijun Ma, Ying Sheng, Maoli Duan, Xiaotong Zhang
BACKGROUND The aim of this study was to investigate the protective effects of acupuncture against gentamicin-induced ototoxicity and explore the possible protective role of neurotrophin-3 (NT-3). MATERIAL AND METHODS Twenty-four rats were divided randomly into 4 groups: control group, gentamicin group, neitinggong group, and tinggong group. Rats in the gentamicin, neitinggong, and tinggong groups received intraperitoneal injection of gentamicin (100 mg/kg) for 14 consecutive days. Rats in the neitinggong and tinggong groups further received acupuncture at neitinggong or tinggong acupoints once every 2 days for 20 days...
January 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28102362/evaluation-of-region-selective-bilirubin-induced-brain-damage-as-a-basis-for-a-pharmacological-treatment
#14
Matteo Dal Ben, Cristina Bottin, Fabrizio Zanconati, Claudio Tiribelli, Silvia Gazzin
The neurologic manifestations of neonatal hyperbilirubinemia in the central nervous system (CNS) exhibit high variations in the severity and appearance of motor, auditory and cognitive symptoms, which is suggestive of a still unexplained selective topography of bilirubin-induced damage. By applying the organotypic brain culture (OBC: preserving in vitro the cellular complexity, connection and architecture of the in vivo brain) technique to study hyperbilirubinemia, we mapped the regional target of bilirubin-induced damage, demonstrated a multifactorial toxic action of bilirubin, and used this information to evaluate the efficacy of drugs applicable to newborns to protect the brain...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28100657/frequency-tuning-of-synaptic-inhibition-underlying-duration-tuned-neurons-in-the-mammalian-inferior-colliculus
#15
Roberto Valdizón-Rodríguez, Paul A Faure
Inhibition plays an important role in creating the temporal response properties of duration-tuned neurons (DTNs) in the mammalian inferior colliculus (IC). Neurophysiological and computational studies indicate that duration selectivity in the IC is created through the convergence of excitatory and inhibitory synaptic inputs offset in time. We used paired tone stimulation and extracellular recording to measure the frequency tuning of the inhibition acting on DTNs in the IC of the big brown bat (Eptesicus fuscus)...
January 18, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28097439/modeling-responses-in-the-superior-paraolivary-nucleus-implications-for-forward-masking-in-the-inferior-colliculus
#16
Nima Salimi, Muhammad S A Zilany, Laurel H Carney
A phenomenological model of the responses of neurons in the superior paraolivary nucleus (SPON) of the rodent is presented in this study. Pure tones at the characteristic frequency (CF) and broadband noise stimuli evoke offset-type responses in these neurons. SPON neurons also phase-lock to the envelope of sinusoidally amplitude-modulated (SAM) stimuli for a range of modulation frequencies. Model SPON neuron received inhibitory input that was relayed by the ipsilateral medial nucleus of the trapezoid body from the contralateral model ventral cochlear nucleus neuron...
January 17, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28078738/dorsal-pallidal-neurons-directly-link-the-nidopallium-and-midbrain-in-the-zebra-finch-taeniopygia-guttata
#17
J Martin Wild
The dorsal pallidum in birds is considered similar, if not homologous, to the globus pallidus (GP) of mammals. The dorsal pallidum projects to both thalamic and midbrain targets similar to the direct and indirect pathways arising from the internal and external segments of the GP. In the present study retrograde and anterograde tracing studies revealed a previously undescribed projection of the avian dorsal pallidum. This arises from a specific dorsomedial component, which terminates in the intercollicular nucleus and partly surrounds the avian equivalent of the central nucleus of the inferior colliculus...
January 12, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28077288/micro-endoscopic-system-for-functional-assessment-of-neural-circuits-in-deep-brain-regions-simultaneous-optical-and-electrical-recordings-of-auditory-responses-in-mouse-s-inferior-colliculus
#18
Hidetaka Yashiro, Ichiro Nakahara, Kazuo Funabiki, Hiroshi Riquimaroux
In vivo Ca(2+) imaging is a powerful method for the functional assessment of neural circuits. Although multi-photon excitation fluorescence microscopy has been widely used, observation of circuits in deep brain regions remains challenging. Recently, observing these deep regions has become possible via an endoscope consisting of an optical fiber bundle or gradient-index lens. We have designed a micro-endoscope system that enables simultaneous optical recording of fluorescence and electrical recording of neural activity...
January 7, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28043881/simultaneously-evoked-auditory-potentials-seap-a-new-method-for-concurrent-measurement-of-cortical-and-subcortical-auditory-evoked-activity
#19
Christopher Slugocki, Daniel Bosnyak, Laurel J Trainor
Recent electrophysiological work has evinced a capacity for plasticity in subcortical auditory nuclei in human listeners. Similar plastic effects have been measured in cortically-generated auditory potentials but it is unclear how the two interact. Here we present Simultaneously-Evoked Auditory Potentials (SEAP), a method designed to concurrently elicit electrophysiological brain potentials from inferior colliculus, thalamus, and primary and secondary auditory cortices. Twenty-six normal-hearing adult subjects (mean 19...
December 31, 2016: Hearing Research
https://www.readbyqxmd.com/read/28009231/the-superior-fovea-triangle-approach-a-novel-safe-entry-zone-to-the-brainstem
#20
Kaan Yagmurlu, M Yashar S Kalani, Mark C Preul, Robert F Spetzler
The authors describe a safe entry zone, the superior fovea triangle, on the floor of the fourth ventricle for resection of deep dorsal pontine lesions at the level of the facial colliculus. Clinical data from a patient undergoing a suboccipital telovelar transsuperior fovea triangle approach to a deep pontine cavernous malformation were reviewed and supplemented with 6 formalin-fixed adult human brainstem and 2 silicone-injected adult human cadaveric heads using the fiber dissection technique to illustrate the utility of this novel safe entry zone...
December 23, 2016: Journal of Neurosurgery
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