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inferior colliculus

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https://www.readbyqxmd.com/read/28795331/cells-expressing-prominin-1-in-neonatal-murine-inferior-colliculus-differentiate-into-neurons-and-glia
#1
Haruka Okazaki, Akira Kanda, Seiji Kanda, Takaki Shimono, Yasutaka Yun, Yoshiki Kobayashi, Zeyun Wang, Hisashi Ooka, Kensuke Suzuki, Dan Bui Van, Koichi Tomoda, Hiroshi Iwai, Toshimasa Nishiyama
Inferior colliculus (IC) is a major center for the integration and processing of acoustic information from ascending auditory pathways. Damage to the IC as well as normal aging can impair auditory function. Novel strategies such as stem cell (SC)-based regenerative therapy are required for functional recovery because mature neural cells have a minimal regenerative capacity after an injury. However, it is not known if there are neural stem cells (NSCs) in the IC. Herein, we screened for NSCs by surface marker analysis using flow cytometry...
August 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28774646/subcortical-and-cortical-correlates-of-pitch-discrimination-evidence-for-two-levels-of-neuroplasticity-in-musicians
#2
Federica Bianchi, Jens Hjortkjær, Sébastien Santurette, Robert J Zatorre, Hartwig R Siebner, Torsten Dau
Musicians are highly trained to discriminate fine pitch changes but the neural bases of this ability are poorly understood. It is unclear whether such training-dependent differences in pitch processing arise already in the subcortical auditory system or are linked to more central stages. To address this question, we combined psychoacoustic testing with functional MRI to measure cortical and subcortical responses in musicians and non-musicians during a pitch-discrimination task. First, we estimated behavioral pitch-discrimination thresholds for complex tones with harmonic components that were either resolved or unresolved in the auditory system...
July 31, 2017: NeuroImage
https://www.readbyqxmd.com/read/28765608/endocannabinoid-modulation-of-stimulus-specific-adaptation-in-inferior-colliculus-neurons-of-the-rat
#3
C Valdés-Baizabal, G G Parras, Y A Ayala, M S Malmierca
Cannabinoid receptors (CBRs) are widely distributed in the brain, including the inferior colliculus (IC). Here, we aim to study whether endocannabinoids influence a specific type of neuronal adaptation, namely, stimulus-specific adaptation (SSA) found in some IC neurons. SSA is important because it has been found as early as the level of the midbrain and therefore it may be a neuronal correlate of early indices of deviance detection. Furthermore, recent studies have demonstrated a direct link between SSA and MMN, that is widely used as an outcome measure in a variety of human neurodegenerative disorders...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28748486/nonlinear-processing-of-a-multicomponent-communication-signal-by-combination-sensitive-neurons-in-the-anuran-inferior-colliculus
#4
Norman Lee, Katrina M Schrode, Mark A Bee
Diverse animals communicate using multicomponent signals. How a receiver's central nervous system integrates multiple signal components remains largely unknown. We investigated how female green treefrogs (Hyla cinerea) integrate the multiple spectral components present in male advertisement calls. Typical calls have a bimodal spectrum consisting of formant-like low-frequency (~0.9 kHz) and high-frequency (~2.7 kHz) components that are transduced by different sensory organs in the inner ear. In behavioral experiments, only bimodal calls reliably elicited phonotaxis in no-choice tests, and they were selectively chosen over unimodal calls in two-alternative choice tests...
July 26, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28747592/investigation-of-spinal-nerve-ligation-mediated-functional-activation-of-the-rat-brain-using-manganese-enhanced-mri
#5
Keun-Yeong Jeong, Ji-Hyuk Kang
To provide clear information on the cerebral regions according to peripheral neuropathy, the functional activation was investigated using manganese-enhanced magnetic resonance imaging (MEMRI). L5-spinal nerve ligation (SNL) was applied to the rats to induce neuropathic pain. Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment. The cerebral regions were investigated using a 4.7T MRI system in the sham, SNL, and GBP-treated SNL rats...
July 26, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28736332/5-hydroxytryptamine-2a-receptors-of-the-dorsal-raphe-nucleus-mediate-panic-like-behaviours-and-fear-induced-antinociception-elicited-by-neuronal-activation-in-the-central-nucleus-of-the-inferior-colliculus
#6
Raimundo da Silva Soares, Luiz Luciano Falconi-Sobrinho, Tayllon Dos Anjos-Garcia, Norberto Cysne Coimbra
It has been established that chemical stimulation of the inferior colliculus (IC) of laboratory animals evokes fear-related defensive responses, which are considered panic attack-like behaviours. In addition, there is evidence that defensive reactions provoked by chemical stimulation of midbrain tectum neurons may induce an antinociceptive response. Morphologically, the IC receives projections from other mesencephalic structures, such as the dorsal raphe nucleus (DRN), a region rich in serotonergic neurons that play a critical role in the control of defensive behaviours...
July 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28720776/dissonance-encoding-in-human-inferior-colliculus-covaries-with-individual-differences-in-dislike-of-dissonant-music
#7
Seung-Goo Kim, Jöran Lepsien, Thomas Hans Fritz, Toralf Mildner, Karsten Mueller
Harmony is one of the most fundamental elements of music that evokes emotional response. The inferior colliculus (IC) has been known to detect poor agreement of harmonics of sound, that is, dissonance. Electrophysiological evidence has implicated a relationship between a sustained auditory response mainly from the brainstem and unpleasant emotion induced by dissonant harmony. Interestingly, an individual's dislike of dissonant harmony of an individual correlated with a reduced sustained auditory response. In the current paper, we report novel evidence based on functional magnetic resonance imaging (fMRI) for such a relationship between individual variability in dislike of dissonance and the IC activation...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717877/temporal-envelope-coding-by-inferior-colliculus-neurons-with-cochlear-implant-stimulation
#8
Kenneth E Hancock, Yoojin Chung, Martin F McKinney, Bertrand Delgutte
Modulations in temporal envelopes are a ubiquitous property of natural sounds and are especially important for hearing with cochlear implants (CIs) because these devices typically discard temporal fine structure information. With few exceptions, neural temporal envelope processing has been studied in both normal hearing (NH) and CI animals using only pure sinusoidal amplitude modulation (SAM) which poorly represents the diversity of envelope shapes contained in natural sounds because it confounds repetition rate and the width of each modulation cycle...
July 17, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28711622/prolonged-low-level-noise-induced-plasticity-in-the-peripheral-and-central-auditory-system-of-rats
#9
Adam M Sheppard, Guang-Di Chen, Senthilvelan Manohar, Dalian Ding, Bo-Hua Hu, Wei Sun, Jiwei Zhao, Richard Salvi
Prolonged low-level noise exposure alters loudness perception in humans, presumably by decreasing the gain of the central auditory system. Here we test the central gain hypothesis by measuring the acute and chronic physiologic changes at the level of the cochlea and inferior colliculus (IC) after a 75-dB SPL, 10-20-kHz noise exposure for 5weeks. The compound action potential (CAP) and summating potential (SP) were used to assess the functional status of the cochlea and 16 channel electrodes were used to measure the local field potentials (LFP) and multi-unit spike discharge rates (SDR) from the IC immediately after and one-week post-exposure...
July 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28660235/a-co-culture-model-for-determining-the-target-specificity-of-the-de-novo-generated-retinal-ganglion-cells
#10
Pooja Teotia, Matthew J Van Hook, Iqbal Ahmad
In glaucoma, the output neurons of the retina, the retinal ganglion cells (RGCs), progressively degenerate, leading to irreversible blindness (Ahram et al., 2015). The ex vivo stem cell method to replace degenerated RGCs remains a potentially viable approach (Levin et al., 2004). However, the success of the approach depends upon the ability of the de novo generated RGCs to connect over the long distance with specific targets in the central visual pathway. Here, we describe a protocol to examine the target specificity of the de novo generated RGCs using a co-culture approach where the RGCs neurites are allowed to choose between specific (superior colliculus; SC) and non-specific (inferior colliculus; IC) tectal targets...
April 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28655419/neural-representations-of-concurrent-sounds-with-overlapping-spectra-in-rat-inferior-colliculus-comparisons-between-temporal-fine-structure-and-envelope
#11
Lu Luo, Qian Wang, Liang Li
Perceptual segregation of multiple sounds, which overlap in both time and spectra, into individual auditory streams is critical for hearing in natural environments. Some cues such as interaural time disparities (ITDs) play an important role in the segregation, especially when sounds are separated in space. In this study, we investigated the neural representation of two uncorrelated narrowband noises that shared the identical spectrum in the rat inferior colliculus (IC) using frequency-following-response (FFR) recordings, when the ITD for each noise stimulus was manipulated...
June 17, 2017: Hearing Research
https://www.readbyqxmd.com/read/28615543/time-course-of-cell-death-due-to-acoustic-overstimulation-in-the-mouse-medial-geniculate-body-and-primary-auditory-cortex
#12
Felix Frohlich, Dietmar Basta, Ira Strübing, Arne Ernst, Moritz Gröschel
It has previously been shown that acoustic overstimulation induces cell death and extensive cell loss in key structures of the central auditory pathway. A correlation between noise-induced apoptosis and cell loss was hypothesized for the cochlear nucleus and colliculus inferior. To determine the role of cell death in noise-induced cell loss in thalamic and cortical structures, the present mouse study (NMRI strain) describes the time course following noise exposure of cell death mechanisms for the ventral medial geniculate body (vMGB), medial MGB (mMGB), and dorsal MGB (dMGB) and the six histological layers of the primary auditory cortex (AI 1-6)...
May 2017: Noise & Health
https://www.readbyqxmd.com/read/28583912/noise-trauma-induced-behavioral-gap-detection-deficits-correlate-with-reorganization-of-excitatory-and-inhibitory-local-circuits-in-the-inferior-colliculus-and-are-prevented-by-acoustic-enrichment
#13
Joshua J Sturm, Ying-Xin Zhang-Hooks, Hannah Roos, Tuan Nguyen, Karl Kandler
Hearing loss leads to a host of cellular and synaptic changes in auditory brain areas that are thought to give rise to auditory perception deficits such as temporal processing impairments, hyperacusis, and tinnitus. However, little is known about possible changes in synaptic circuit connectivity that may underlie these hearing deficits. Here, we show that mild hearing loss as a result of brief noise exposure leads to a pronounced reorganization of local excitatory and inhibitory circuits in the mouse inferior colliculus...
June 28, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28559383/spatial-processing-is-frequency-specific-in-auditory-cortex-but-not-in-the-midbrain
#14
Joseph Sollini, Robert Mill, Christian J Sumner
The cochlea behaves like a bank of band-pass filters, segregating information into different frequency channels. Some aspects of perception reflect processing within individual channels, but others involve the integration of information across them. One instance of this is sound localization, which improves with increasing bandwidth. The processing of binaural cues for sound location has been studied extensively. However, although the advantage conferred by bandwidth is clear, we currently know little about how this additional information is combined to form our percept of space...
July 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28528846/the-multi-level-impact-of-chronic-intermittent-hypoxia-on-central-auditory-processing
#15
Eddie Wong, Bin Yang, Lida Du, Wai Hong Ho, Condon Lau, Ya Ke, Ying Shing Chan, Wing Ho Yung, Ed X Wu
During hypoxia, the tissues do not obtain adequate oxygen. Chronic hypoxia can lead to many health problems. A relatively common cause of chronic hypoxia is sleep apnea. Sleep apnea is a sleep breathing disorder that affects 3-7% of the population. During sleep, the patient's breathing starts and stops. This can lead to hypertension, attention deficits, and hearing disorders. In this study, we apply an established chronic intermittent hypoxemia (CIH) model of sleep apnea to study its impact on auditory processing...
May 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28446582/auditory-fear-conditioning-modifies-steady-state-evoked-potentials-in-the-rat-inferior-colliculus
#16
André Luiz Vieira Lockmann, Flávio Afonso Gonçalves Mourão, Marcio Flávio Dutra Moraes
The rat inferior colliculus (IC) is a major midbrain relay for ascending inputs from the auditory brain stem and has been suggested to play a key role in the processing of aversive sounds. Previous studies have demonstrated that auditory fear conditioning (AFC) potentiates transient responses to brief tones in the IC, but it remains unexplored whether AFC modifies responses to sustained periodic acoustic stimulation-a type of response called the steady-state evoked potential (SSEP). Here we used an amplitude-modulated tone-a 10-kHz tone with a sinusoidal amplitude modulation of 53...
August 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28431308/hyperexcitability-of-inferior-colliculus-and-acoustic-startle-reflex-with-age-related-hearing-loss
#17
Binbin Xiong, Ana'am Alkharabsheh, Senthilvelan Manohar, Guang-Di Chen, Ning Yu, Xiaoming Zhao, Richard Salvi, Wei Sun
Chronic tinnitus and hyperacusis often develop with age-related hearing loss presumably due to aberrant neural activity in the central auditory system (CAS) induced by cochlear pathologies. However, the full spectrum of physiological changes that occur in the CAS as a result age-related hearing loss are still poorly understood. To address this issue, neurophysiological measures were obtained from the cochlea and the inferior colliculus (IC) of 2, 6 and 12 month old C57BL/6J mice, a mouse model for early age-related hearing loss...
March 27, 2017: Hearing Research
https://www.readbyqxmd.com/read/28392756/brain-metabolic-changes-in-rats-following-acoustic-trauma
#18
Jun He, Yejin Zhu, Jiye Aa, Paul F Smith, Dirk De Ridder, Guangji Wang, Yiwen Zheng
Acoustic trauma is the most common cause of hearing loss and tinnitus in humans. However, the impact of acoustic trauma on system biology is not fully understood. It has been increasingly recognized that tinnitus caused by acoustic trauma is unlikely to be generated by a single pathological source, but rather a complex network of changes involving not only the auditory system but also systems related to memory, emotion and stress. One obvious and significant gap in tinnitus research is a lack of biomarkers that reflect the consequences of this interactive "tinnitus-causing" network...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28392470/pituitary-adenylate-cyclase-activating-polypeptide-pacap-and-its-receptor-1-pac1-in-the-human-infant-brain-and-changes-in-the-sudden-infant-death-syndrome-sids
#19
J Huang, K A Waters, R Machaalani
Pituitary adenylate cyclase activating polypeptide (PACAP) and its complementary receptor, PAC1, are crucial in central respiratory control. PACAP Knockout (KO) mice exhibit a SIDS-like phenotype, with an inability to overcome noxious insults, compression of baseline ventilation, and death in the early post-neonatal period. PAC1 KO demonstrate similar attributes to PACAP-null mice, but with the addition of increased pulmonary artery pressure, consequently leading to heart failure and death. This study establishes a detailed interpretation of the neuroanatomical distribution and localization of both PACAP and PAC1 in the human infant brainstem and hippocampus, to determine whether any changes in expression are evident in infants who died of Sudden Infant Death Syndrome (SIDS) and any relationships to risk factors of SIDS including smoke exposure and sleep related parameters...
April 6, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28381487/neural-coding-of-time-varying-interaural-time-differences-and-time-varying-amplitude-in-the-inferior-colliculus
#20
Nathaniel Zuk, Bertrand Delgutte
Binaural cues occurring in natural environments are frequently time varying, either from the motion of a sound source or through interactions between the cues produced by multiple sources. Yet, a broad understanding of how the auditory system processes dynamic binaural cues is still lacking. In the current study, we directly compared neural responses in the inferior colliculus (IC) of unanesthetized rabbits to broadband noise with time-varying interaural time differences (ITD) with responses to noise with sinusoidal amplitude modulation (SAM) over a wide range of modulation frequencies...
July 1, 2017: Journal of Neurophysiology
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