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https://www.readbyqxmd.com/read/28101963/extreme-biophysics-enzymes-under-pressure
#1
Qi Huang, Jocelyn M Rodgers, Russell J Hemley, Toshiko Ichiye
A critical question about piezophilic (pressure-loving) microbes is how their constituent molecules maintain function under high pressure. Here, factors are examined that may lead to the increased activity under pressure in dihydrofolate reductase from the piezophilic Moritella profunda compared to the homologous enzyme from the mesophilic Escherichia coli. Molecular dynamics simulations are performed at various temperatures and pressures to examine how pressure affects the flexibility of the enzymes from these two microbes, since both stability and flexibility are necessary for enzyme activity...
January 19, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28101914/prenatal-stress-exposure-generates-higher-early-survival-and-smaller-size-without-impacting-developmental-rate-in-a-pacific-salmon
#2
Pauline M Capelle, Christina A D Semeniuk, Natalie M Sopinka, John W Heath, Oliver P Love
Prenatal exposure to elevated glucocorticoids can act as a signal of environmental stress, resulting in modifications to offspring phenotype. While "negative" phenotypic effects (i.e., smaller size, slower growth) are often reported, recent research coupling phenotype with other fitness-related traits has suggested positive impacts of prenatal stress. Using captive Chinook salmon (Oncorhynchus tshawytscha), we treated eggs with biologically relevant cortisol levels-low (300 ng mL(-1) ), high (1,000 ng mL(-1) ), or control (0 ng mL(-1) )-to examine the early-life impacts of maternally transferred stress hormones on offspring...
January 18, 2017: Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
https://www.readbyqxmd.com/read/28100576/perioperative-management-of-a-large-late-presenting-phaeochromocytoma
#3
Duncan Macrosson, Andrew Love
A 77-year-old man presenting to the emergency department with an acute coronary syndrome was later found to have a phaeochromocytoma. The lateness of this presentation was likely due to the protective α blocking effects of long-term terazosin therapy for his prostatism. α blockers such as terazosin are a well-recognised medical therapy in the perioperative optimisation of phaeochromocytoma because they treat the adrenergic effects of catecholamine release from the tumour such as hypertension. This patient was diagnosed with an ST elevation myocardial infarction (STEMI)...
January 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28093419/the-risk-of-fracture-among-patients-with-psoriatic-arthritis-and-psoriasis-a-population-based-study
#4
Alexis Ogdie, Lauren Harter, Daniel Shin, Joshua Baker, Junko Takeshita, Hyon K Choi, Thorvardur Jon Love, Joel M Gelfand
OBJECTIVE: To determine the risk of fracture and osteoporosis among patients with psoriatic arthritis (PsA) and psoriasis, compared with the general population and patients with rheumatoid arthritis (RA). METHODS: A population-based cohort study was performed in The Health Improvement Network in the UK using data from 1994 to 2014. Patients aged 18-89 years with PsA or psoriasis and up to five unexposed controls matched by practice and start date within that practice were included...
January 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28092715/-family-a-challenge-for-the-future-of-our-earth
#5
Gilberto A Gamboa-Bernal
The Universal Declaration of Human Rights recognizes the family as the basic cell of society, highlighting its importance, the need to protect it, to promote it as a natural and fundamental group unit of society. To reflect on the effects that the actual culture is in the family is important from the situation as it is now presented, then move to raise the changes seen necessary to ensure their own future and that of their habitat that is Earth. To accomplish this first task some study results World Family Map 2015 is glossed...
September 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28090533/professor-julie-mcmullen-love-what-you-do-do-what-you-love
#6
Crystal M Yan
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28087727/bioethics-and-imagination-towards-a-narrative-bioethics-committed-to-social-action-and-justice
#7
Camilo Hernán Manchola Castillo, Jan Helge Solbakk
Recently, the involvement of various authors coming from the social sciences and the arts has reinforced the humanistic component of bioethics. Their contributions vary from very theoretical perspectives to rather practical ones. In this paper, Martha Nussbaum's books, The Fragility of Goodness (1986), Love's Knowledge (1990), Cultivating Humanity (1997) and Creating Capabilities (2011) are analysed from the vantage point of narrative bioethics. It is argued that Nussbaum's notions of 'Narrative', 'Imagination' and 'Cultivation' open up the possibility of developing an action-oriented form of narrative bioethics, that is, a bioethics committed to social action and justice...
January 13, 2017: Medical Humanities
https://www.readbyqxmd.com/read/28087303/activity-levels-and-exercise-motivation-in-copd-patients-and-their-resident-loved-ones
#8
Rafael Mesquita, Nienke Nakken, Daisy J A Janssen, Esther H A van den Bogaart, Jeannet M L Delbressine, Johannes M N Essers, Kenneth Meijer, Monique van Vliet, Geeuwke J de Vries, Jean W M Muris, Fabio Pitta, Emiel F M Wouters, Martijn A Spruit
BACKGROUND: Resident loved ones of patients with COPD can play an important role in helping patients to engage in physical activity. We aimed to compare activity levels and exercise motivation between COPD patients and their resident loved ones; to compare the same outcome measures in patients after stratification for the physical activity level of the loved ones; and to predict the likelihood of being physically active in patients with a physically active resident loved one. METHODS: 125 patient-loved one dyads were cross-sectionally and simultaneously assessed...
January 10, 2017: Chest
https://www.readbyqxmd.com/read/28085637/co-occurrence-of-and-recovery-from-substance-abuse-and-lifespan-victimization-a-qualitative-study-of-female-residents-in-trauma-informed-sober-living-homes
#9
Katie M Edwards, Sharon Murphy, Kelly M Palmer, Ellen E Haynes, Sara Chapo, Britta A Ekdahl, Sara Buel
Despite the co-occurrence of substance use disorders (SUDs) and domestic and/or sexual violence (DSV) in the lives of women, there remains a dearth of research on how and why these phenomena intersect as well as the role that trauma-informed sober living homes (SLHs) may play in promoting recovery. Following a detailed description of a unique trauma-informed SLH (Support, Education, Empowerment, and Directions [SEEDs]), we present findings from a qualitative study that documented the perceptions and lived experiences of 28 female current or former residents of a trauma-informed SLH; all women had histories of SUDs and DSV...
January 13, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28085576/contact-isolation-precautions-in-trauma-patients-an-analysis-of-infectious-complications
#10
Mark E Hamill, Christopher R Reed, Sandy L Fogel, Eric H Bradburn, Kinga A Powers, Katie M Love, Christopher C Baker, Bryan R Collier
BACKGROUND: Victims of traumatic injuries represent a population at risk for a wide variety of complications. Contact isolation (CI) is a set of restrictions designed to help prevent the transmission of medically significant organisms in the healthcare setting. A growing body of literature demonstrates that CI can have significant implications for the individual isolated patient. Our goal was to characterize the use of contact isolation at our Level I trauma center and investigate the association of CI with infectious complications...
January 13, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28084382/a-paediatric-dct-s-life-i-love-the-challenge-of-dealing-with-worried-children
#11
(no author information available yet)
No abstract text is available yet for this article.
January 13, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28082280/serum-metabolomic-profiles-identify-er-positive-early-breast-cancer-patients-at-increased-risk-of-disease-recurrence-in-a-multicenter-population
#12
Christopher D Hart, Alessia Vignoli, Leonardo Tenori, Gemma Leonora Uy, Ta Van To, Clement Adebamowo, Syed Mozammel Hossain, Laura Biganzoli, Emanuela Risi, Richard R Love, Claudio Luchinat, Angelo Di Leo
PURPOSE: Detecting signals of micrometastatic disease in patients with early breast cancer (EBC) could improve risk stratification and allow better tailoring of adjuvant therapies. We previously showed that postoperative serum metabolomic profiles were predictive of relapse in a single-center cohort of estrogen receptor (ER)-negative EBC patients. Here, we investigated this further using preoperative serum samples from ER-positive, premenopausal women with EBC who were enrolled in an international phase III trial...
January 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28082188/molecular-epidemiology-of-hiv-1-in-iceland-early-introductions-transmission-dynamics-and-recent-outbreaks-among-injection-drug-users
#13
Malik Sallam, Joakim Esbjörnsson, Guðrún Baldvinsdóttir, Hlynur Indriðason, Thora Björg Björnsdóttir, Anders Widell, Magnús Gottfreðsson, Arthur Löve, Patrik Medstrand
The molecular epidemiology of HIV-1 in Iceland has not been described so far. Detailed analyses of the dynamics of HIV-1 can give insights for prevention of virus spread. The objective of the current study was to characterize the genetic diversity and transmission dynamics of HIV-1 in Iceland. Partial HIV-1 pol (1020bp) sequences were generated from 230 Icelandic samples, representing 77% of all HIV-1 infected individuals reported in the country 1985-2012. Maximum likelihood phylogenies were reconstructed for subtype/CRF assignment and determination of transmission clusters...
January 7, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28076532/-trajectories-of-women-living-with-hiv-aids-in-brazil-progress-and-permanence-of-the-response-to-the-epidemic
#14
Wilza Vieira Villela, Regina Maria Barbosa
This article analyzes the trajectories of 85 women living with HIV/AIDS in six Brazilian cities: Belém, São Paulo, Ribeirão Preto, Goiânia, Recife and Pelotas, to understand some specific aspects of their experiences before and after diagnosis. It is based on in-depth interviews conducted in 2009 addressing women diagnosed with HIV between 1 and 20 years previously. The results show a profile characterized by limited access to school, health services and labor and a marked presence of violence. The reasons for applying HIV tests vary over time and there is an increase in prenatal testing, although no modifications in the context of the infection are apparent...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28074585/a-good-death
#15
Tia Powell, Adira Hulkower
A good death is hard to find. Family members tell us that loved ones die in the wrong place-the hospital-and do not receive high-quality care at the end of life. This issue of the Hastings Center Report offers two articles from authors who strive to provide good end-of-life care and to prevent needless suffering. We agree with their goals, but we have substantial reservations about the approaches they recommend. Respect for the decisions of patients and their surrogates is a relatively new and still vulnerable aspect of medical care...
January 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28073737/using-real-time-social-media-technologies-to-monitor-levels-of-perceived-stress-and-emotional-state-in-college-students-a-web-based-questionnaire-study
#16
Sam Liu, Miaoqi Zhu, Dong Jin Yu, Alexander Rasin, Sean D Young
BACKGROUND: College can be stressful for many freshmen as they cope with a variety of stressors. Excess stress can negatively affect both psychological and physical health. Thus, there is a need to find innovative and cost-effective strategies to help identify students experiencing high levels of stress to receive appropriate treatment. Social media use has been rapidly growing, and recent studies have reported that data from these technologies can be used for public health surveillance...
January 10, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28072893/a-pediatric-application-of-the-strac-regional-hospital-trauma-registry-database-pediatric-trauma-deaths-in-south-central-texas-during-2004-2013
#17
Michelle Buehner, Jay Aden, Mathew Borgman, Preston Love, Brandi Wright, Mary Edwards
The purpose of this study was to define the demographics of pediatric traumatic injuries and to understand the predictive value of injury type, prehospital, and emergency department (ED) data regarding the mortality of pediatric trauma patients (<14 years of age) in South Central Texas. We report a retrospective review of pediatric trauma patients presenting to Trauma Service Area P in South Central Texas during 2004-2013. The primary outcome was mortality; secondary outcomes were ventilator days, hospital days, and intensive care unit stay...
January 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28071836/violated-and-vulnerable-women-s-experiences-of-contracting-a-sexually-transmitted-infection-from-a-male-partner
#18
Leah East, Debra Jackson, Kath Peters
AIMS AND OBJECTIVES: The aim of this paper is to explore women's stories of contracting a sexually transmitted infection from a male partner and elucidate the gendered constructs and violence experienced that made the women vulnerable to these infections. BACKGROUND: Violence against women can result in both physical and psychological consequences and expose women to multiple health risks including sexual health adversity. DESIGN: Feminist storytelling approach...
January 10, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28070172/summary-of-the-2016-partners-against-mortality-in-epilepsy-pame-conference
#19
(no author information available yet)
Authors: Kevin D Graber, MD, Jeffrey Buchhalter, MD, PhD, Elson So, MD, Rainer Surges, MD, Detlev Boison, PhD, Franck Kalume, PhD, Cyndi Wright, Brian Gehlbach, MD, Jeff Noebels, MD, PhD, Vicky Whittemore, PhD, Elizabeth J. Donner, MD, MSc, Tom Stanton, MPP, Henry Smithson, MD, Jane Hanna, Masud Seyal, MD, PhD, Philippe Ryvlin, MD, PhD The third biannual Partners Against Mortality in Epilepsy (PAME) conference was held in Alexandria, VA from June 23-26, 2016. This was an intimate meeting of clinical and basic scientists, clinicians, people affected by Sudden Unexpected Death in Epilepsy Patients (SUDEP) in a loved one, people living with epilepsy and patient advocate organizations...
November 2016: Epilepsy Currents
https://www.readbyqxmd.com/read/28070052/-survey-on-changes-in-the-proportion-for-facial-aesthetics
#20
Shize Lei, Qizhen Wu, Qingmei Shi, Shaorong Lei
To explore the proportion for facial aesthetics that may be recognized by the potential group who will do plastic surgery in the future. 
 Methods: We measured the celebrity photos, who were born before 1980 recognizable by the people over 40 years old or by high school students. The proportions for facial aesthetics recognizable by these two generations were obtained and compared. 
 Results: Compared the new generation of male celebrities with the older generation of male celebrities, the difference was statistically significant by the independent samples t test (t=-2...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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