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Karl Lorenzen
Each work in this collection explores, from patients' or their loved ones' points of view, balance between patients' experiences and one or more of 4 well-known principles of ethics in health care.
July 1, 2018: AMA Journal of Ethics
Betsy Rolland, Jordan Eschler
Background: Cancer survivorship presents unique medical, psychosocial, and logistical challenges for survivors, their caregivers, and clinicians. NCI-designated Comprehensive Cancer Centers (CCCs) serve a unique role in the delivery of cancer care because they not only provide care but also serve as a model for community oncologists and clinics through the development and dissemination of standards of care. Survivors, their caregivers, and clinicians look to CCCs to provide information about how to navigate the transition from active to posttreatment care...
July 2018: Journal of the National Comprehensive Cancer Network: JNCCN
James Love-Koh, Alison Peel, Juan Carlos Rejon-Parilla, Kate Ennis, Rosemary Lovett, Andrea Manca, Anastasia Chalkidou, Hannah Wood, Matthew Taylor
OBJECTIVE: Precision medicine allows healthcare interventions to be tailored to groups of patients based on their disease susceptibility, diagnostic or prognostic information, or treatment response. We analysed what developments are expected in precision medicine over the next decade and considered the implications for health technology assessment (HTA) agencies. METHODS: We performed a pragmatic literature search to account for the large size and wide scope of the precision medicine literature...
July 13, 2018: PharmacoEconomics
Love Ahlström, Michal Odermarsky, Torsten Malm, Jens Johansson Ramgren, Petru Liuba
In transposition of the great arteries (TGA), certain coronary patterns have been associated with major adverse events early after the arterial switch operation (ASO). We sought to determine the impact of preoperative echocardiographic (ECHO) diagnosis on the intra- and postoperative morbidity. All patients with TGA born between June 2001 and June 2017 and who underwent ASO were reviewed. Data on presumed coronary anatomy (CA) preoperatively were obtained from the preoperative ECHO report. Intraoperative CA was categorized according to Yacoub classification...
July 12, 2018: Pediatric Cardiology
Kris Niño G Valdehuesa, Kristine Rose M Ramos, Grace M Nisola, Angelo B Bañares, Rhudith B Cabulong, Won-Keun Lee, Huaiwei Liu, Wook-Jin Chung
The D-xylose oxidative pathway (XOP) has recently been employed in several recombinant microorganisms for growth or for the production of several valuable compounds. The XOP is initiated by D-xylose oxidation to D-xylonolactone, which is then hydrolyzed into D-xylonic acid. D-Xylonic acid is then dehydrated to form 2-keto-3-deoxy-D-xylonic acid, which may be further dehydrated then oxidized into α-ketoglutarate or undergo aldol cleavage to form pyruvate and glycolaldehyde. This review introduces a brief discussion about XOP and its discovery in bacteria and archaea, such as Caulobacter crescentus and Haloferax volcanii...
July 12, 2018: Applied Microbiology and Biotechnology
Polly L Arnold, Jennifer C Green, Malcolm L H Green, Alexander F R Kilpatrick, Richard A Layfield, Jason B Love, Dermot O'Hare, John F C Turner
Professor Geoff Cloke FRS celebrates his 65th birthday in 2018. In a career spanning four decades, his research endeavours have accounted for some of the most innovative synthetic chemistry of the modern era, with his many publications describing truly exceptional compounds and experimental methods that portray a unique chemical imagination. In addition to his scientific accomplishments, Cloke can be particularly proud of his successful mentoring, a level of dedication that propelled many students and post-docs on to become research leaders in their own right...
July 13, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Valarie Blue Bird Jernigan, Mary Williams, Marianna Wetherill, Tori Taniguchi, Tvli Jacob, Tamela Cannady, Mandy Grammar, Joy Standridge, Jill Fox, AnDina Wiley, JoAnna Tingle, Mary Riley, Jennifer Spiegel, Charlotte Love, Carolyn Noonan, Ashley Weedn, Alicia L Salvatore
In rural Native American communities, access to healthy foods is limited and diet-related disparities are significant. Tribally owned and operated convenience stores, small food stores that sell ready-to-eat foods and snacks primarily high in fat and sugar, serve as the primary and, in some areas, the only food stores. The Tribal Health and Resilience in Vulnerable Environments or "THRIVE" study, implemented between 2013 and 2018, is the first healthy retail intervention study implemented in tribally owned and operated convenience stores...
September 2018: Preventive Medicine Reports
James A Cotton, Matthew Berriman, Love Dalén, Ian Barnes
No abstract text is available yet for this article.
July 13, 2018: Science
Rachel E Carter, Corey T Love
Li-ion battery safety is often threatened by undesirable lithium metal electrodeposition, or dendrite growth, during charging. The unpredictable and complex onset of widely ranging lithium morphologies limits reproducibility, making prevention and detection strategies difficult to assess. This work blends the fundamentals of classical metallurgical dendrite growth with traditional Li-ion battery charging, to prove the ability to modulate lithium metal deposition behavior through an applied interelectrode thermal gradient...
July 12, 2018: ACS Applied Materials & Interfaces
Eydis E Runarsdottir, Anna I Gunnarsdottir, Thorvardur J Love, Petur S Gunnarsson, Bjorn Gudbjornsson
OBJECTIVES: To identify the proportion of patients with psoriatic arthritis (PsA) who would meet inclusion criteria of the randomised clinical trials that were performed leading up to registration of the tumour necrosis factor inhibitors (TNFi). METHODS: Data from 329 patients with PsA were obtained from an Icelandic database, ICEBIO, medical records at the University Hospital of Iceland, and the private out-patient clinic Laeknasetrid Ltd. The patients were classified according to whether they met the inclusion criteria of the clinical trials that were performed ahead of the registration of each respective TNFi...
June 14, 2018: Clinical and Experimental Rheumatology
Martin D Venturas, John S Sperry, David M Love, Ethan H Frehner, Michael G Allred, Yujie Wang, William R L Anderegg
Empirical models of plant drought responses rely on parameters that are difficult to specify a priori. We test a trait- and process-based model to predict environmental responses from an optimization of carbon gain vs hydraulic risk. We applied four drought treatments to aspen (Populus tremuloides) saplings in a research garden. First we tested the optimization algorithm by using predawn xylem pressure as an input. We then tested the full model which calculates root-zone water budget and xylem pressure hourly throughout the growing season...
July 12, 2018: New Phytologist
William Affleck, Umaharan Thamotharampillai, Judy Jeyakumar, Rob Whitley
Refugee men face unique mental health stressors in the pre- and post-migratory periods. However, there has been little in-depth research on the mental health of refugee men in Canada. Given this situation, the overall aim of this study is to explore the psycho-social experience of Sri Lankan Tamil refugee men in Canada. Particular objectives include better understanding any inter-relationship between war-trauma, migration, concepts of masculinity and mental health. The study employed a two-phase participatory action research design based on the grounded theory approach...
July 12, 2018: Culture, Medicine and Psychiatry
Lianne Gonsalves, Michelle J Hindin, Angela Bayer, Cesar P Carcamo, Peter Gichangi, Ndema Habib, Jefferson Mwaisaka, Lale Say
BACKGROUND: Young people face special challenges to accessing needed sexual and reproductive health (SRH) information and support. With high penetration and access, mobile phones provide a new channel for reaching young people, but there is little evidence around the impact of digital interventions on improving health outcomes. The Adolescent/Youth Reproductive Mobile Access and Delivery Initiative for Love and Life Outcomes (ARMADILLO) study will assess the effect of an intervention providing SRH information to young people via text message on their mobile phones in Kenya and Peru...
July 11, 2018: Reproductive Health
Alison Berent-Spillson, Angela S Kelley, Carol C Persad, Tiffany Love, Kirk A Frey, Nancy E Reame, Robert Koeppe, Jon-Kar Zubieta, Yolanda R Smith
OBJECTIVE: Cognitive outcomes in trials of postmenopausal hormone treatment have been inconsistent. Differing outcomes may be attributed to hormone formulation, treatment duration and timing, and differential cognitive domain effects. We previously demonstrated treatment benefits on visual cognitive function. In the present study, we describe the effects of hormone treatment on verbal outcomes in the same women, seeking to understand the effects of prior versus current hormone treatment on verbal function...
July 9, 2018: Menopause: the Journal of the North American Menopause Society
Aziza Ahmed
This Article emerges from Fordham Law Reviews Symposium on the fiftieth anniversary of Loving v. Virginia, the case that found antimiscegenation laws unconstitutional. Inspired by the need to interrogate the regulation of race in the context of family, this Article examines the diffuse regulatory environment around assisted reproductive technology (ART) that shapes procreative decisions and the inequalities that these decisions may engender. ART both centers biology and raises questions about how we imagine our racial futures in the context of family, community, and nation...
May 2018: Fordham Law Review
A P Kiely, S Miners, R Courtney, C Strand, S Love, J L Holton
AIMS: There is evidence that accumulation of α-synuclein (α-syn) in Parkinson's disease (PD) and dementia with Lewy bodies (DLB) results from impaired removal of α-syn rather than its overproduction. Kallikrein-6 (KLK6), calpain-1 (CAPN1) and cathepsin-D (CTSD) are among a small number of proteases that cleave α-syn and are dysregulated in PD and DLB. Our aim in this study was to determine whether protease activity is altered in another α-synucleinopathy, multiple system atrophy (MSA), and might thereby modulate the regional distribution of α-syn accumulation...
July 11, 2018: Neuropathology and Applied Neurobiology
Aldis H Petriceks
No abstract text is available yet for this article.
July 11, 2018: Palliative & Supportive Care
Dennis Adu-Gyasi, Kwaku Poku Asante, Margaret T Frempong, Dennis Konadu Gyasi, Louisa Fatahiya Iddrisu, Love Ankrah, David Dosoo, Elisha Adeniji, Oscar Agyei, Stephaney Gyaase, Seeba Amenga-Etego, Ben Gyan, Seth Owusu-Agyei
Background: Helminths are among the most widespread infectious agents prevalent in tropical and sub-tropical regions of the developing world defined by inadequate sanitation, poverty and unsafe water sources. This study was carried out to describe the distribution of helminth and malaria parasite infections in the middle-belt of Ghana in sub-Saharan Africa where disease burden, including anaemia is rife and helminths are perceived to be significant contributors of the burden. Methods: A cross-sectional survey involving 1826 residents located in the middle belt of Ghana where no or very little previous community-based helminth work had been carried out...
August 2018: Parasite Epidemiology and Control
May-May Meijer, Femke Meijer
No abstract text is available yet for this article.
July 9, 2018: Schizophrenia Bulletin
Abraham D Flaxman, Lisa Harman, Jonathan Joseph, Jonathan Brown, Christopher J L Murray
As part of the Gates Grand Challenge 13, the Population Health Metrics Research Consortium (PHMRC) collected data to enable the development and validation of methods that measure cause-specific mortality in populations with incomplete or inadequate cause of death coding. This work yielded 11,979 verbal autopsy interviews (VAIs). In each, a field interviewer spoke with an individual familiar with the deceased and their final illness, and used a semi-structured questionnaire to collect information about the symptoms of the deceased in their final illness...
April 17, 2018: Gates open research
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