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https://www.readbyqxmd.com/read/28431087/a-method-for-learning-a-sparse-classifier-in-the-presence-of-missing-data-for-high-dimensional-biological-datasets
#1
Kristen Severson, Brinda Monian, J Christopher Love, Richard D Braatz
Motivation: This work addresses two common issues in building classification models for biological or medical studies: learning a sparse model, where only a subset of a large number of possible predictors is used, and training in the presence of missing data. This work focuses on supervised generative binary classification models, specifically linear discriminant analysis (LDA). The parameters are determined using an expectation maximization algorithm to both address missing data and introduce priors to promote sparsity...
April 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28431000/left-brain-asymmetry-of-the-planum-temporale-in-a-nonhominid-primate-redefining-the-origin-of-brain-specialization-for-language
#2
Damien Marie, Muriel Roth, Romain Lacoste, Bruno Nazarian, Alice Bertello, Jean-Luc Anton, William D Hopkins, Konstantina Margiotoudi, Scott A Love, Adrien Meguerditchian
The planum temporale (PT) is a critical region of the language functional network in the human brain showing a striking size asymmetry toward the left hemisphere. Historically considered as a structural landmark of the left-brain specialization for language, a similar anatomical bias has been described in great apes but never in monkeys-indicating that this brain landmark might be unique to Hominidae evolution. In the present in vivo magnetic resonance imaging study, we show clearly for the first time in a nonhominid primate species, an Old World monkey, a left size predominance of the PT among 96 olive baboons (Papio anubis), using manual delineation of this region in each individual hemisphere...
April 19, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28430345/healing-response-of-rat-pulp-treated-with-an-injectable-keratin-hydrogel
#3
Lavanya Ajay Sharma, Robert M Love, Mohammad A Ali, Ajay Sharma, Soraia Macari, Avadhoot Avadhani, George J Dias
BACKGROUND: Keratin has shown promising outcomes as a biomaterial due to its inherent bioactivity, biocompatibility and regenerative effects. The effect of keratin on repair and regeneration of dental tissues has never been studied before. Current therapies to treat pulp tissues involve its replacement with inert, synthetic materials that do not have a proper biological function, leading to failure and tooth loss. This study aimed to develop a biocompatible keratin hydrogel (KH) suitable for pulp therapies...
April 20, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28429767/love-laughs-at-locksmiths-ubiquitylation-of-p62-sequestosome-1-unlocks-its-autophagy-receptor-potential
#4
Owen Conway, Vladimir Kirkin
The multimodular adapter p62/sequestosome-1 plays prominent roles in physiology and disease by mediating cell signaling and cargo degradation. The work by Peng et al. published recently in Cell Research provides mechanistic insights into activation of its autophagy receptor function critical for maintaining cell homeostasis during various forms of stress.
April 21, 2017: Cell Research
https://www.readbyqxmd.com/read/28427557/oxidative-stress-love-and-hate-history-in-central-nervous-system
#5
Genaro Gabriel Ortiz, Fermín P Pacheco Moisés, Mario Mireles-Ramírez, Luis J Flores-Alvarado, Héctor González-Usigli, Víctor J Sánchez-González, Angélica L Sánchez-López, Lorenzo Sánchez-Romero, Eduardo I Díaz-Barba, J Francisco Santoscoy-Gutiérrez, Paloma Rivero-Moragrega
Molecular oxygen is essential for aerobic organisms in order to synthesize large amounts of energy during the process of oxidative phosphorylation and it is harnessed in the form of adenosine triphosphate, the chemical energy of the cell. Oxygen is toxic for anaerobic organisms but it is also less obvious that oxygen is poisonous to aerobic organisms at higher concentrations of oxygen. For instance, oxygen toxicity is a condition resulting from the harmful effects of breathing molecular oxygen at increased partial pressures...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28426438/perceptions-and-attitudes-of-romanian-people-toward-autopsy-procedures-according-to-the-level-of-knowledge
#6
Daniela Marinescu, Gellért Attila Gyurka, Roxana Miclăuş, Codruţa Nemet, Liliana Rogozea
In the last decade, Romanian hospitals have been facing a decline in autopsy rates. This has had a negative impact on medical education and the training of young doctors. Quite a number of caregivers strongly oppose the carrying out of autopsies on their deceased loved ones who have died in hospital. Hence, this study was designed to evaluate how autopsies are perceived by an average person and whether improved knowledge about autopsies would help reduce people's reluctance toward them. The study involved 216 willing participants who had either never had a loved one die in hospital or had never had the power to make a decision about their dead loved ones' body...
April 20, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28426030/1-3-n-o-complexes-of-late-transition-metals-ligands-with-flexible-bonding-modes-and-reaction-profiles
#7
REVIEW
Marcus W Drover, Jennifer A Love, Laurel L Schafer
1,3-N,O-Chelating ligands are ubiquitous in nature owing to their occurrence as α-chiral amino acids in metalloproteins. These structural units also display diverse coordination modes, which lend themselves to applications in catalysis as well as novel fundamental stoichiometric reactivity, including the activation of inert bonds. This review comments on recent developments in N,O-ligated late transition metal complexes with an emphasis on preparation, characterization, and reactivity.
April 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28424246/enteropathy-associated-t-cell-lymphoma-subtypes-are-characterized-by-loss-of-function-of-setd2
#8
Andrea B Moffitt, Sarah L Ondrejka, Matthew McKinney, Rachel E Rempel, John R Goodlad, Chun Huat Teh, Sirpa Leppa, Susanna Mannisto, Panu E Kovanen, Eric Tse, Rex K H Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, Javeed Iqbal, Jiayu Yu, Kikkeri Naresh, Diego Villa, Randy D Gascoyne, Jonathan Said, Magdalena B Czader, Amy Chadburn, Kristy L Richards, Deepthi Rajagopalan, Nicholas S Davis, Eileen C Smith, Brooke C Palus, Tiffany J Tzeng, Jane A Healy, Patricia L Lugar, Jyotishka Datta, Cassandra Love, Shawn Levy, David B Dunson, Yuan Zhuang, Eric D Hsi, Sandeep S Dave
Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT pathway was the most frequently mutated pathway, with frequent mutations in STAT5B as well as JAK1, JAK3, STAT3, and SOCS1 We also identified mutations in KRAS, TP53, and TERT Type I EATL and type II EATL (monomorphic epitheliotropic intestinal T cell lymphoma) had highly overlapping genetic alterations indicating shared mechanisms underlying their pathogenesis...
April 19, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28424072/prevalence-of-intimate-partner-violence-and-its-association-with-symptoms-of-depression-a-cross-sectional-study-based-on-a-female-population-sample-in-sweden
#9
Solveig Lövestad, Jesper Löve, Marjan Vaez, Gunilla Krantz
BACKGROUND: Intimate Partner Violence (IPV) is the most common type of violence targeting women. IPV includes acts of physical aggression, sexual coercion, psychological abuse and controlling behaviors and these forms of violence often coexist in the same relationship. Living with IPV is associated with serious mental health outcomes such as depression and depressive symptoms. Few population based studies from Sweden have investigated the relationship between different forms of IPV and women's depressive symptoms and even fewer used controlling behavior as an independent variable in such studies...
April 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28422290/heroin-related-deaths-from-the-hennepin-county-medical-examiner-s-office-from-2004-through-2015
#10
Sara A Love, Jessica Lelinski, Julie Kloss, Owen Middleton, Fred S Apple
Over the past two decades, prescription and illicit opioid use has led to changes in public health policy to address the increasing number of opioid-related deaths. The purpose of this study was to review cases from Hennepin County Medical Examiner's Office between 2004 through 2015 where heroin was listed as a significant contributor or as the cause of death. We identified 322 heroin-related deaths, which were predominantly male (255; 79%). 6-Monoacetylmorphine (6-MAM) median (range) concentrations were as follows: blood (n = 7), 0...
April 19, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28420266/lessons-learned-from-the-field-testing-of-healthy-love-an-hiv-prevention-intervention-for-black-women
#11
Carla A Galindo, Tai E Few, Brandy Daniels, Carolyn P Parks, Dázon D Diallo, L Nyrobi N Moss, Aisha L Wilkes, G Chezia Carraway
BACKGROUND: Healthy Love is a brief, highly interactive, single-session, group-level HIV prevention intervention designed for African American women that is effective at reducing sex risk behaviors and increasing condom use and HIV testing among participants. The Centers for Disease Control and Prevention, through a contract, developed a user-friendly intervention package that would allow organizations to adopt and implement Healthy Love with fidelity. METHOD: Training and implementation materials were developed to support original research protocols, and piloted and revised to conduct field-testing with case study agencies (CSAs)...
May 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28414628/fried-green-tomatoes-and-the-color-purple-a-case-study-in-lesbian-friendship-and-cultural-controversy
#12
Kristen Proehl
Published in the 1980s, Fannie Flagg's Fried Green Tomatoes at the Whistle Stop Café and Alice Walker's The Color Purple are lesbian coming-of-age narratives that share a great deal in common in terms of their thematic content, publication histories, and cultural afterlives. In both novels, female friendships are shaped by patriarchal violence and develop in the context of the rural, segregated, early twentieth-century U.S. South. But the two novels also diverge in significant ways, as differences in race, gender, class, and sexuality shape their protagonists' experiences of love and friendship...
April 17, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28414304/transforming-activity-and-therapeutic-targeting-of-c-terminal-binding-protein-2-in-apc-mutated-neoplasia
#13
E T Sumner, A T Chawla, A D Cororaton, J E Koblinski, R C Kovi, I M Love, B B Szomju, S Korwar, K C Ellis, S R Grossman
Overexpression of the transcriptional coregulators C-terminal binding proteins 1 and 2 (CtBP1 and 2) occurs in many human solid tumors and is associated with poor prognosis. CtBP modulates oncogenic gene expression programs and is an emerging drug target, but its oncogenic role is unclear. Consistent with this oncogenic potential, exogenous CtBP2 transformed primary mouse and human cells to anchorage independence similarly to mutant H-Ras. To investigate CtBP's contribution to in vivo tumorigenesis, Apc(min/+) mice, which succumb to massive intestinal polyposis, were bred to Ctbp2(+/-) mice...
April 17, 2017: Oncogene
https://www.readbyqxmd.com/read/28414141/temporal-role-of-macrophages-in-cancellous-bone-healing
#14
Olof Helge Sandberg, Love Tätting, Magnus Erik Bernhardsson, Per Aspenberg
Macrophages are important phagocytosing and cytokine producing cells with effects on fracture healing. We used clodronate-containing liposomes to reduce the number of macrophages, in order to study their role in the early phases of cancellous bone healing. Holes were drilled bilaterally into the cancellous bone of the proximal metaphysis of the tibia of 60 mice. A screw was inserted in the hole in the right tibia. The day of surgery was day 0. Clodronate-containing liposomes were injected intraperitoneally as a single injection either day -4 or -1 (before surgery) or day 1 or 3 (after surgery)...
April 14, 2017: Bone
https://www.readbyqxmd.com/read/28413909/sticking-to-the-romantic-script-an-examination-of-love-life-scripts-stories-and%C3%A2-self-reports-of-normality
#15
William L Dunlop, Grace E Hanley, Tara P McCoy, Nicole Harake
Life scripts represent cultural expectations regarding the events in the prototypical life whereas life stories represent narrative constructions of the events occurring in individuals' own lives. In Study 1, we generated an outline of the love life script and a list of the self-definitional events individuals tend to associate with their own love lives. Participants were prompted to produce and rate seven important events in the prototypical love life and several significant moments from their own love lives...
April 16, 2017: Memory
https://www.readbyqxmd.com/read/28412660/gold-nanoparticle-based-low-limit-of-detection-love-wave-biosensor-for-carcinoembryonic-antigens
#16
Shuangming Li, Ying Wan, Yan Su, Chunhai Fan, Venkat R Bhethanabotla
In this work, a Love wave biosensing platform is described for detecting cancer-related biomarker carcinoembryonic antigen (CEA). An ST 90°-X quartz Love wave device with a layer of SiO2 waveguide was combined with gold nanoparticles (Au NPs) to amplify the mass loading effect of the acoustic wave sensor to achieve a limit of detection of 37pg/mL. The strategy involves modifying the Au NPs with anti-CEA antibody conjugates to form nanoprobes in a sandwich immunoassay. The unamplified detection limit of the Love wave biosensor is 9...
April 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28412477/impact-of-major-life-events-on-breast-cancer-specific-mortality-a-case-fatality-study-on-8000-breast-cancer-patients
#17
Sanna Heikkinen, Joonas Miettinen, Eero Pukkala, Markku Koskenvuo, Nea Malila, Janne Pitkäniemi
BACKGROUND: It has been suggested that long-term activation of the body's stress-response system and subsequent overexposure to stress hormones may be associated with increased morbidity. However, evidence on the impact of major life events on mortality from breast cancer (BC) remains inconclusive. The main aim of this study is to investigate whether major negatively or positively experienced life events before or after diagnosis have an effect on BC-specific mortality in women who have survived with BC for at least 2 years...
April 13, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28411666/-psychological-support-for-people-bereaved-by-suicide
#18
Thierry Fouet
For several years, the Deux-Sèvres department has been providing psychological support to people bereaved after the suicide of a loved one. The care provision is collaborative and coordinated.
April 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28411103/-endogenous-regeneration-engineering-growth-factors-for-stroke
#19
REVIEW
Su Jing Chan, Christopher Love, Myron Spector, Simon M Cool, Victor Nurcombe, Eng H Lo
Despite the efforts in developing therapeutics for stroke, recombinant tissue plasminogen activator (rtPA) remains the only FDA approved drug for ischemic stroke. Regenerative medicine targeting endogenous growth factors has drawn much interest in the clinical field as it provides potential restoration for the damaged brain tissue without being limited by a narrow therapeutic window. To date, most of the translational studies using regenerative medicines have encountered problems and failures. In this review, we discuss the effects of some trophic factors which include of erythropoietin (EPO), brain derived neurotrophic factor (BDNF), granulocyte-colony stimulating factor (G-CSF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF) and heparin binding epidermal growth factor (HB-EGF) in experimental ischemic stroke models and elaborate the lost in translation of the candidate growth factors from bench to bedside...
April 11, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28410972/fostering-resilience-among-mothers-under-stress-authentic%C3%A2-connections-groups-for-medical-professionals
#20
Suniya S Luthar, Alexandria Curlee, Susannah J Tye, Judith C Engelman, Cynthia M Stonnington
BACKGROUND: We report on effects of an intervention to foster resilience among professional women at high risk for stress and burnout: health care providers (physicians, PhD clinicians, physician assistants, and nurse practitioners) who are mothers. METHODS: Between February and November 2015, 40 mothers on staff at the Mayo Clinic, Arizona, were assigned randomly to either 1) 12 weekly 1-hour sessions of a structured, relational supportive intervention, the Authentic Connections Groups (n = 21) with protected time to attend sessions or to 2) 12 weekly hours of protected time to be used as desired (controls; n = 19)...
April 7, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
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