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https://www.readbyqxmd.com/read/28734469/falling-back-in-love-with-emergency-medicine
#1
EDITORIAL
Andrea L Austin
No abstract text is available yet for this article.
August 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28733470/dendritic-cell-targeted-lentiviral-vector-immunization-uses-pseudotransduction-and-dna-mediated-sting-and-cgas-activation
#2
Jocelyn T Kim, Yarong Liu, Rajan P Kulkarni, Kevin K Lee, Bingbing Dai, Geoffrey Lovely, Yong Ouyang, Pin Wang, Lili Yang, David Baltimore
Dendritic cell (DC) activation and antigen presentation are critical for efficient priming of T cell responses. Here, we study how lentiviral vectors (LVs) deliver antigen and activate DCs to generate T cell immunization in vivo. We report that antigenic proteins delivered in vector particles via pseudotransduction were sufficient to stimulate an antigen-specific immune response. The delivery of the viral genome encoding the antigen increased the magnitude of this response in vivo but was irrelevant in vitro...
July 21, 2017: Science Immunology
https://www.readbyqxmd.com/read/28733227/captivity-influences-immune-responses-stress-endocrinology-and-organ-size-in-house-sparrows-passer-domesticus
#3
Ashley C Love, Matthew B Lovern, Sarah E DuRant
Studies using wild animals in laboratory-based research require bringing wild-captured organisms into a novel setting, which can have long-lasting impacts on physiology and behavior. In several species, captivity stimulates stress hormone production and can alter immune function. Despite this, there is little consensus on how captivity influences stress hormone regulation, or if captivity-induced changes in stress hormone production and regulation mediate changes in immune function. In this study, we investigate the influence of captivity on the physiology of a wild bird commonly-used in laboratory-based research, the house sparrow (Passer domesticus)...
July 18, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28731715/tandem-oxidative-dearomatizing-spirocyclizations-of-propargyl-guanidines-and-ureas
#4
Ravi P Singh, Jayanta Das, Muhammed Yousufuddin, Delphine Gout, Carl J Lovely
Treatment of propargyl ureas or guanidines with iodosobenzene diacetate results in an oxidative tandem amination/etherification dearomatizing spirocyclization. This transformation leads directly to the complete framework of the Leucetta alkaloids, spirocalcaridine A and B.
July 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28731446/effect-of-apoe-genotype-on-synaptic-proteins-in-earlier-adult-life
#5
Lindsey I Sinclair, Seth Love
BACKGROUND: Possession of APOEɛ4 is a strong risk factor for late-onset Alzheimer's disease and is associated with loss of synaptic proteins in the elderly even in the absence of Alzheimer's disease. OBJECTIVE: We hypothesized that ɛ4 allele possession in non-demented adults aged under-75 would also be associated with alterations in the levels of synaptic proteins. METHODS: We measured synaptophysin, PSD95, drebrin, SNAP-25, and septin 7 by ELISA in hippocampus and superior temporal gyrus from 103 adults aged <75 without dementia...
July 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28727156/safety-and-effectiveness-of-a-6-french-mri-conditional-pacemaker-lead-the-ingevitytm-clinical-investigation-study-results
#6
Jens C Nielsen, Michael Giudici, Jose Maria Tolasana Viu, Engwooi Chew, Elke Sommerijns, Nicholas Wold, Linda Evert, Charles J Love, Kenneth Stein, Hedrich Olaf
BACKGROUND: The design of pacemaker leads has continued to evolve; ease of lead handling, improved electrical performance and MRI conditional aspects have become more important, while safety remains critical. The INGEVITY™ family leads was designed to provide MRI conditional aspects, decreased diameter, and improved performance of pacemaker leads. The INGEVITY study is an investigational device exemption trial evaluating the acute and chronic safety and effectiveness of these leads...
July 20, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28726272/does-maternity-care-coordination-influence-perinatal-health-care-utilization-evidence-from-north-carolina
#7
Marianne M Hillemeier, Marisa E Domino, Rebecca Wells, Ravi K Goyal, Hye-Chung Kum, Dorothy Cilenti, Anirban Basu
OBJECTIVE: To examine effects of maternity care coordination (MCC) on perinatal health care utilization among low-income women. DATA SOURCES: North Carolina Center for Health Statistics Baby Love files that include birth certificates, maternity care coordination records, WIC records, and Medicaid claims. STUDY DESIGN: Causal effects of MCC participation on health care outcomes were estimated in a sample of 7,124 singleton Medicaid-covered births using multiple linear regressions with inverse probability of treatment weighting (IPTW)...
July 20, 2017: Health Services Research
https://www.readbyqxmd.com/read/28725425/letter-to-the-editor-health-professionals-attitudes-toward-individuals-with-eating-disorders-who-do-we-think-they-are
#8
Deborah Lynn Reas, Kjersti Solhaug Gulliksen, Johanna Levallius, Rasmus Isomaa
Health professionals are not immune to stigmatizing attitudes and stereotypes found in society-at-large. Along with patients and their loved ones, treatment providers are important stakeholders - and gatekeepers - in the successful delivery of mental healthcare. Prevailing attitudes among professionals can facilitate timely recognition, enable access to care and uptake of evidence-based practices, or undermine help-seeking and therapeutic engagement. At an interactive activity at the 2016 Nordic Eating Disorders Society (NEDS) meeting, we asked health professionals to describe individuals with eating disorders...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28725320/splice-site-variants-in-the-kcnq1-and-scn5a-genes-transcript-analysis-as-a-tool-in-supporting-pathogenicity
#9
Ivone U S Leong, Philippa A Dryland, Debra O Prosser, Stella W-S Lai, Mandy Graham, Martin Stiles, Jackie Crawford, Jonathan R Skinner, Donald R Love
BACKGROUND: Approximately 75% of clinically definite long QT syndrome (LQTS) cases are caused by mutations in the KCNQ1, KCNH2 and SCN5A genes. Of these mutations, a small proportion (3.2-9.2%) are predicted to affect splicing. These mutations present a particular challenge in ascribing pathogenicity. METHODS: Here we report an analysis of the transcriptional consequences of two mutations, one in the KCNQ1 gene (c.781_782delinsTC) and one in the SCN5A gene (c.2437-5C>A), which are predicted to affect splicing...
August 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28725282/addiction-and-the-brain-development-not-disease
#10
Marc Lewis
I review the brain disease model of addiction promoted by medical, scientific, and clinical authorities in the US and elsewhere. I then show that the disease model is flawed because brain changes in addiction are similar to those generally observed when recurrent, highly motivated goal seeking results in the development of deep habits, Pavlovian learning, and prefrontal disengagement. This analysis relies on concepts of self-organization, neuroplasticity, personality development, and delay discounting. It also highlights neural and behavioral parallels between substance addictions, behavioral addictions, normative compulsive behaviors, and falling in love...
2017: Neuroethics
https://www.readbyqxmd.com/read/28724989/impact-of-interfacial-molecular-orientation-on-radiative-recombination-and-charge-generation-efficiency
#11
Niva A Ran, Steffen Roland, John A Love, Victoria Savikhin, Christopher J Takacs, Yao-Tsung Fu, Hong Li, Veaceslav Coropceanu, Xiaofeng Liu, Jean-Luc Brédas, Guillermo C Bazan, Michael F Toney, Dieter Neher, Thuc-Quyen Nguyen
A long standing question in organic electronics concerns the effects of molecular orientation at donor/acceptor heterojunctions. Given a well-controlled donor/acceptor bilayer system, we uncover the genuine effects of molecular orientation on charge generation and recombination. These effects are studied through the point of view of photovoltaics-however, the results have important implications on the operation of all optoelectronic devices with donor/acceptor interfaces, such as light emitting diodes and photodetectors...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28724296/the-influence-of-relationships-on-the-meaning-making-process-patients-perspectives
#12
Danetta Hendricks Sloan, Karlynn BrintzenhofeSzoc, Erin Mistretta, M Jennifer Cheng, Ann Berger
BACKGROUND: The diagnosis of a chronic or life limiting illness followed by treatment often requires an adjustment to life goals and expectations. With added existential concerns, patients' struggle to redefine life meaning while also finding ways to alleviate any distress that may occur. Central to the work of many scholars, meaning making is thought to be a vital component of negotiating traumatic life events while also essential to the positive adjustment in chronic illness and healing...
July 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28721765/-my-clinical-nurse-specialist-is-always-there-to-offer-advice-and-support
#13
(no author information available yet)
Joanne King is such a lovely, caring person, and it means a lot as a patient when you're cared for by someone like that.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28720729/inhibition-of-inflammasome-dependent-interleukin-1%C3%AE-production-by-streptococcal-nad-glycohydrolase-evidence-for-extracellular-activity
#14
Dóra Hancz, Elsa Westerlund, Benedicte Bastiat-Sempe, Onkar Sharma, Christine Valfridsson, Lena Meyer, John F Love, Maghnus O'Seaghdha, Michael R Wessels, Jenny J Persson
Group A Streptococcus (GAS) is a common human pathogen and the etiologic agent of a large number of diseases ranging from mild, self-limiting infections to invasive life-threatening conditions. Two prominent virulence factors of this bacterium are the genetically and functionally linked pore-forming toxin streptolysin O (SLO) and its cotoxin NAD(+)-glycohydrolase (NADase). Overexpression of these toxins has been linked to increased bacterial virulence and is correlated with invasive GAS disease. NADase can be translocated into host cells by a SLO-dependent mechanism, and cytosolic NADase has been assigned multiple properties such as protection of intracellularly located GAS bacteria and induction of host cell death through energy depletion...
July 18, 2017: MBio
https://www.readbyqxmd.com/read/28720021/ricky-and-lucy-gender-stereotyping-among-young-black-men-who-have-sex-with-men-in-the-us-deep-south-and-the-implications-for-hiv-risk-in-a-severely-affected-population
#15
Bronwen Lichtenstein, Emma Sophia Kay, Ian Klinger, Matt G Mutchler
HIV disproportionately affects young Black men who have sex with men in the USA, with especially high rates in the Deep South. In this Alabama study, we interviewed 24 pairs of young Black men who have sex with men aged 19-24 and their close friends (n = 48) about sexual scripts, dating men and condom use. Three main themes emerged from the study: the power dynamics of 'top' and 'bottom' sexual positions for condom use; gender stereotyping in the iconic style of the 'I Love Lucy' show of the 1950s; and the sexual dominance of 'trade' men...
July 19, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28720010/determinants-and-predictors-of-grief-severity-and-persistence-the-rotterdam-study
#16
Jelena Milic, Taulant Muka, M Arfan Ikram, Oscar H Franco, Henning Tiemeier
OBJECTIVE: We aimed to explore correlates and predictors of bereavement severity and persistence (triggered by "loss of a loved one"; referent group partner loss) in the Rotterdam cohort. METHOD: We used linear regression to examine factors associated with grief severity using a cross-sectional analysis and logistic regression to determine prospective associations. RESULTS: Cross-sectionaly, females, child-lost, higher depressive symptoms, lower education, and difficulties in daily activities were independently associated with a higher bereavement severity...
July 1, 2017: Journal of Aging and Health
https://www.readbyqxmd.com/read/28719248/the-efficacy-of-dignity-therapy-on-the-psychological-well-being-in-loved-ones-of-terminally-ill-patients
#17
Miguel Julião
No abstract text is available yet for this article.
July 18, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28718931/army-soldiers-and-suicidal-thoughts-the-impact-of-negative-relationship-dynamics-moderated-by-the-dissolution-of-romantic-relationships
#18
Heather A Love, Jared A Durtschi, Lauren M Ruhlmann, Briana S Nelson Goff
Suicide among United States active-duty Army soldiers rapidly increased over the past two decades. Using a sample of 322 soldiers from the Army STARRS study, the researchers examined if romantic relationship factors (i.e., hostile disagreements and relationship distress) were linked with suicidal thoughts in Army soldiers, and if these associations were moderated by a recent separation or divorce. Hostile disagreements and relational distress were both significantly associated with higher rates of suicidal ideation...
July 18, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28717768/symptom-levels-in-care-seeking-bangladeshi-and-nepalese-adults-with-advanced-cancer
#19
Richard Reed Love, Tahmina Ferdousy, Bishnu D Paudel, Shamsun Nahar, Rumana Dowla, Mohammad Adibuzzaman, Golam Mushih Tanimul Ahsan, Miftah Uddin, Reza Salim, Sheikh Iqbal Ahamed
PURPOSE: Three-fourths of patients with advanced cancer are reported to suffer from pain. A primary barrier to provision of adequate symptom treatment is failure to appreciate the intensity of the symptoms patients are experiencing. Because data on Bangladeshi and Nepalese patients' perceptions of their symptomatic status are limited, we sought such information using a cell phone questionnaire. METHODS: At tertiary care centers in Dhaka and Kathmandu, we recruited 640 and 383 adult patients, respectively, with incurable malignancy presenting for outpatient visits and instructed them for that single visit on one-time completion of a cell phone platform 15-item survey of questions about common cancer-associated symptoms and their magnitudes using Likert scales of 0 to 10...
June 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717720/first-of-all-i-feel-very-loved-humanism-and-cancer-care-in-south-india
#20
Christopher M Booth
No abstract text is available yet for this article.
December 2016: Journal of Global Oncology
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