Jessica A Noche, Hamsanandini Radhakrishnan, Margo F Ubele, Kathy Boaz, Jennifer L Mefford, Erin D Jones, Jessica A Perpich, Katie McCarty, Beverly Meacham, Jeffrey Smiley, Stasia A Bembenek Bailey, László G Puskás, David K Powell, Lorena Sordo, Michael J Phelan, Christopher M Norris, Elizabeth Head, Craig E L Stark
Aging dogs serve as a valuable preclinical model for Alzheimer's disease (AD) due to their natural age-related development of beta-amyloid (Aβ) plaques, human-like metabolism, and large brains that are ideal for studying structural brain aging trajectories from serial neuroimaging. Here we examined the effects of chronic treatment with the calcineurin inhibitor (CNI) tacrolimus or the nuclear factor of activated T cells (NFAT)-inhibiting compound Q134R on age-related canine brain atrophy from a longitudinal study in middle-aged beagles (36 females, 7 males) undergoing behavioral enrichment...
April 1, 2024: Journal of Neuroscience