keyword
MENU ▼
Read by QxMD icon Read
search

B1 cell

keyword
https://www.readbyqxmd.com/read/29225033/mutant-p53-gains-its-function-via-c-myc-activation-upon-cdk4-phosphorylation-at-serine-249-and-consequent-pin1-binding
#1
Peng Liao, Shelya X Zeng, Xiang Zhou, Tianjian Chen, Fen Zhou, Bo Cao, Ji Hoon Jung, Giannino Del Sal, Shiwen Luo, Hua Lu
TP53 missense mutations significantly influence the development and progression of various human cancers via their gain of new functions (GOF) through different mechanisms. Here we report a unique mechanism underlying the GOF of p53-R249S (p53-RS), a p53 mutant frequently detected in human hepatocellular carcinoma (HCC) that is highly related to hepatitis B infection and aflatoxin B1. A CDK inhibitor blocks p53-RS's nuclear translocation in HCC, whereas CDK4 interacts with p53-RS in the G1/S phase of the cells, phosphorylates it, and enhances its nuclear localization...
November 23, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29218861/comparative-expression-patterns-of-sox2-and-sox19-genes-in-the-forebrain-of-developing-and-adult-turbot-scophthalmus-maximus
#2
Xoana Taboada, Ana Viñas, Fátima Adrio
The turbot, Scophthalmus maximus, belongs to the flatfishes (order Pleuronectiformes), which display substantial asymmetry of the olfactory organs and forebrain. Sox genes code for SRY-related HMG domain-bearing transcription factors involved in various developmental processes. Group B1 Sox genes as Sox2 and Sox19 appear to play major roles in neural development. Here, we characterized by in situ hybridization the developmental expression of Sox2 and Sox19 genes in metamorphic and postmetamorphic specimens and young adults of both sexes...
December 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29218083/overexpression-and-biological-function-of-mef2d-in-human-pancreatic-cancer
#3
Zhiwang Song, Chan Feng, Yonglin Lu, Yong Gao, Yun Lin, Chunyan Dong
To explore the expression, clinical significance, biological function, and potential mechanism of MEF2D in pancreatic cancer, the expression of MEF2D in human pancreatic cancer tissues and corresponding adjacent normal tissues was analyzed through immunohistochemical staining. The association between MEF2D expression, clinicopathological parameters, overall survival, and disease-free survival was evaluated. Human pancreatic cancer cell lines BxPC-1 and SW1990 were selected to investigate the effect of MEF2D knockdown on cell proliferation, migration, and invasion...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217775/chemotherapy-induced-differential-cell-cycle-arrest-in-b-cell-lymphomas-affects-their-sensitivity-to-wee1-inhibition
#4
Xiaoguang Wang, Zhangguo Chen, Ameet K Mishra, Alexa Silva, Wenhua Ren, Zenggang Pan, Jing H Wang
Chemotherapeutic agents, e.g., cytarabine or doxorubicin cause DNA damages. However, it remains unknown whether such agents differentially regulate cell cycle arrest in distinct types of B cell lymphomas, and whether this phenotype can be exploited for developing new therapies. Here, we treated various types of B cells including primary and B lymphoma cells, with cytarabine or doxorubicin, and determined DNA damage responses, cell cycle regulation and sensitivity to Wee1 inhibitor. We found that cyclin A2/B1 upregulation appear to be an intrinsic programmed response to DNA damage; however, different types of B cells arrest in distinct phases of cell cycle...
December 7, 2017: Haematologica
https://www.readbyqxmd.com/read/29215297/virulence-genes-and-antimicrobial-resistance-in-escherichia-coli-from-cheese-made-from-unpasteurized-milk-in-brazil
#5
Anna C L P de Campos, Juan J Puño-Sarmiento, Leonardo P Medeiros, Luís E S Gazal, Renato Pariz Maluta, Armando Navarro, Renata K T Kobayashi, Eder P Fagan, Gerson Nakazato
Cow raw milk cheese is widely eaten in Brazil. These products may be contaminated with pathogenic bacteria. In this work, we investigated the presence of Escherichia coli in raw milk cheese from different States in Brazil. From 147 "Minas" cheese samples, 28 cheeses were positive for E. coli. Among 39 E. coli isolates of the cheeses, one was positive for eae and negative for bpfA and efa1/lifA using PCR, and so was classified as atypical Enteropathogenic E. coli (aEPEC). Two other isolates were positive for extraintestinal pathogenic E...
December 7, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29214018/transcriptional-changes-in-mesenteric-and-subcutaneous-adipose-tissue-from-holstein-cows-in-response-to-plane-of-dietary-energy
#6
S J Moisá, P Ji, J K Drackley, S L Rodriguez-Zas, J J Loor
Background: Dairy cows can readily overconsume dietary energy during most of the prepartum period, often leading to higher prepartal concentrations of insulin and glucose and excessive body fat deposition. The end result of these physiologic changes is greater adipose tissue lipolysis post-partum coupled with excessive hepatic lipid accumulation and compromised health. Although transcriptional regulation of the adipose response to energy availability is well established in non-ruminants, such regulation in cow adipose tissue depots remains poorly characterized...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29213265/lactobacillus-plantarum-mys6-ameliorates-fumonisin-b1-induced-hepatorenal-damage-in-broilers
#7
B V Deepthi, Rakesh Somashekaraiah, K Poornachandra Rao, N Deepa, N K Dharanesha, K S Girish, M Y Sreenivasa
Fumonisin B1 (FB1), a mycotoxin produced by Fusarium species is a predominant Group 2B carcinogen occurring in maize and maize-based poultry feeds. It is shown to be nephrotoxic, hepatotoxic, neurotoxic, and immunosuppressing in animals. In this study, we report the ameliorating effects of a probiotic strain, Lactobacillus plantarum MYS6 on FB1-induced toxicity and oxidative damage in broilers. A 6-week dietary experiment consisting of 48 broilers was performed in six treatment groups. Probiotic treatment (109 cells/mL) involved pre-colonization of broilers with L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29212573/knockdown-of-nf-%C3%AE%C2%BAb1-by-shrna-inhibits-the-growth-of-renal-cell-carcinoma-in-vitro-and-in-vivo
#8
Amanda Ikegami, Luiz Felipe S Teixeira, Marina S Braga, Matheus Henrique Dos S Dias, Eduardo C Lopes, Maria Helena Bellini
Renal cell carcinoma (RCC) accounts for approximately 2-3% of human malignancies and is the most aggressive among urologic tumors. Biological heterogeneity, drug resistance and chemotherapy side effects are the biggest obstacles to the effective treatment of RCC. The NF-кB transcription factor is one of several molecules identified to be responsible for the aggressive phenotype of this tumor. In the past decade, several studies have demonstrated the activation of NF-kB in RCC, and many implicated NF-κB1 (p50) as an important molecule in tumor progression and metastasis...
December 1, 2017: Oncology Research
https://www.readbyqxmd.com/read/29212221/inhibited-effects-of-cape-pno2-on-cervical-carcinoma-in-vivo-and-in-vitro-and-its-detected-metabolites
#9
Xiaofang Yao, Hao Tang, Qiao Ren, Xiaoyan Zhao, Hua Zuo, Zhubo Li
The development of advanced cervical cancer therapies is a particularly urgent need due to the strong side effects and toxicities of current treatments. Caffeic acid phenethyl ester (CAPE) exhibits broad-spectrum antitumor activities and little toxicity or side effects. In our previous study, caffeic acid para-nitro phenethyl ester (CAPE-pNO2) significantly improved the effect of anti-platelet aggregation and attenuated myocardial ischemia. Based on this finding, we aimed to further explore the antitumor activity of CAPE-pNO2 in cervical cancer cells and tumor xenografts...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211897/effect-of-yeast-cell-wall-on-the-growth-performance-and-gut-health-of-broilers-challenged-with-aflatoxin-b1-and-necrotic-enteritis
#10
N Liu, J Q Wang, S C Jia, Y K Chen, J P Wang
This study aimed to investigate the effect of yeast cell walls (YCW) on the growth performance, visceral lesions, intestinal integrity, enterotoxicity, and bacteria of broilers challenged with aflatoxin B1 (AF) and necrotic enteritis (NE) from 1 to 21 d of age. A total of 576 one-day-old broilers were assigned to a 2 × 2 × 2 design for diets containing AFB1 (0 or 40 μg/kg), NE (challenged or unchallenged), or YCW (0 or 500 mg/kg). The main effect analysis showed that AF depressed (P < 0.01) average daily feed intake (ADFI), average daily body weight gain (ADG), the mRNA profiles of polymeric Ig receptor (pIgR), claudin-1, and occludin, but increased (P < 0...
December 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/29211892/evaluation-of-the-effect-of-live-lasota-newcastle-disease-virus-vaccine-as-primary-immunization-on-immune-development-in-broilers
#11
J C S Martinez, W K Chou, L R Berghman, J B Carey
Newcastle disease remains a major concern to the poultry industry; however, it can be managed with effective vaccination programs. The main objective of this study was to evaluate the effect of 2 1× doses of live LaSota strain Newcastle disease virus (NDV) vaccine administered oculo-nasally on d one and 21 on development of humoral and cell-mediated immune response in broilers, and to compare different immunization schedules. Two experiments were conducted. In Experiment I (n = 320), Ross 308 birds were randomly assigned to an unvaccinated control group or vaccinated treatment...
December 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/29211121/evolution-of-periodontal-disease-immune-response-and-rank-rankl-opg-system
#12
Fabrício Gibertoni, Meire Ellen Ligia Sommer, Marcelo Augusto Marretto Esquisatto, Maria Esméria Corezola do Amaral, Camila Andrea de Oliveira, Thiago Antônio Moretti de Andrade, Fernanda Aparecida Sampaio Mendonça, Milton Santamaria-Jr, Maíra Felonato
The aim of this study was to evaluate markers of bone loss and immune response present in evolution of periodontal disease. One hundred and two Wistar rats were divided into three animals groups: PD0, without ligation and PD15 days and PD60 days, submitted to ligation placement with a sterile 3-0 silk cord in the cervical region of the upper first molar on both sides. Samples were obtained from the gingival tissue for histomorphometric analysis, immunohistochemical analysis of RANK, RANKL, OPG, characterization of the inflammatory infiltrate, quantification of nitric oxide, MCP-1, RANTES, IP10 chemokines, and expression of the TGF-b1, VEG, and bFGF...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29208485/lactational-exposure-of-polychlorinated-biphenyls-impairs-leydig-cellular-steroidogenesis-in-f1-progeny-rats
#13
Sathish Kumar Thangavelu, Sugantha Priya Elaiyapillai, Ilangovan Ramachandran, Ravi Sankar Bhaskaran, Arunakaran Jagadeesan
The present study was aimed to determine the effects of lactational exposure of PCBs (Aroclor 1254) on Leydig cellular steroidogenesis in F1 progeny rats. Lactating dams were orally treated by gavage with different doses of PCBs (1, 2 and 5mg/kg b.wt./day). Male progenies were sacrificed on PND60. Our results demonstrated that exposure to PCBs decreased the body weight, testis weight and anogenital distance (AGD) index in the F1 progeny rats. Importantly, PCBs exposure reduced the serum levels of LH, testosterone and estradiol...
December 2, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29204736/effect-of-bacterial-lipopolysaccharides-on-morphogenetic-activity-in-wheat-somatic-calluses
#14
Nina V Evseeva, Oksana V Tkachenko, Gennady L Burygin, Larisa Yu Matora, Yuriy V Lobachev, Sergei Yu Shchyogolev
We evaluated the effect of lipopolysaccharides from the plant-growth-promoting associative bacterium Azospirillum brasilense Sp245 and from the enteric bacterium Escherichia coli K12 on the morphogenic potential of in vitro-growing somatic calluses of soft spring wheat (Triticum aestivum L. cv. Saratovskaya 29). A genetic model was used that included two near-isogenic lines of T. aestivum L. cv. Saratovskaya 29 with different embryogenic capacities; one of these lines carries the Rht-B1 dwarfing gene, whereas the other lacks it...
December 4, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29203270/b-1-cells-upregulate-cd8-t-lymphocytes-and-increase-proinflammatory-cytokines-serum-levels-in-oral-encephalitozoonosis
#15
Denise Langanke Dos Santos, Anuska Marcelino Alvares-Saraiva, José Guilherme Xavier, Diva Denelle Spadacci-Morena, Giovani Bravin Peres, Paulo Ricardo Dell'Armelina Rocha, Elizabeth Christina Perez, Maria Anete Lallo
Microsporidia are intracellular pathogens that cause severe disease in immunocompromised humans and animals. We recently demonstrated that XID mice are more susceptible to Encephalitozoon cuniculi infection by intraperitoneal route, evidencing the role of B-1 cells in resistance against infection. The present study investigated the resistance and susceptibility against E. cuniculi oral infection, including the role of B-1 cells. BALB/c and BALB/c XID (B-1 cells deficient) mice were orally infected with E. cuniculi spores...
December 1, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29197046/evaluation-of-nutritional-status-post-laparoscopic-sleeve-gastrectomy-5-year-outcomes
#16
Salman Al-Sabah, Aliaa Al-Mutawa, Alfred Kojo Anderson, Mohammad Al-Mutawa
INTRODUCTION: Obesity is considered a public health problem and has led to advancements in bariatric surgery. Laparoscopic sleeve gastrectomy (LSG) had become the most performed procedure worldwide; however, its consequences on nutritional status in the short and long term are of concern. METHODS: A retrospective analysis of medical records and bariatric database of patients who underwent LSG from October 2008-September 2015 at Al-Amiri Hospital, Kuwait, was performed...
December 1, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29196913/ubap2l-silencing-inhibits-cell-proliferation-and-g2-m-phase-transition-in-breast-cancer
#17
Jing He, Yuanping Chen, Lu Cai, Zelei Li, Xiaoqing Guo
BACKGROUND: Ubiquitin-associated protein 2-like (UBAP2L) contains a ubiquitin-associated domain near its N-terminus, which has been demonstrated to be overexpressed in multiple tumors, including hepatocellular carcinoma and colorectal carcinoma but its role has not been well studied in breast cancer. Thus, this study was designed to evaluate whether UBAP2L can serve as a potential molecular target for breast cancer therapy. METHODS: The expression of UBAP2L was determined in breast cancer tissues and cell lines by Western blotting and Oncomine database mining...
December 1, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29196159/cholesterol-trafficking-and-raft-like-membrane-domain-composition-mediate-scavenger-receptor-class-b-type-1-dependent-lipid-sensing-in-intestinal-epithelial-cells
#18
Etienne Morel, Sara Ghezzal, Géraldine Lucchi, Caroline Truntzer, Jean-Paul Pais de Barros, Françoise Simon-Plas, Sylvie Demignot, Chieko Mineo, Philip W Shaul, Armelle Leturque, Monique Rousset, Véronique Carrière
Scavenger receptor Class B type 1 (SR-B1) is a lipid transporter and sensor. In intestinal epithelial cells, SR-B1-dependent lipid sensing is associated with SR-B1 recruitment in raft-like/ detergent-resistant membrane domains and interaction of its C-terminal transmembrane domain with plasma membrane cholesterol. To clarify the initiating events occurring during lipid sensing by SR-B1, we analyzed cholesterol trafficking and raft-like domain composition in intestinal epithelial cells expressing wild-type SR-B1 or the mutated form SR-B1-Q445A, defective in membrane cholesterol binding and signal initiation...
November 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29195484/targeted-delivery-of-garcinia-glycosides-by-reconstituted-high-density-lipoprotein-nano-complexes
#19
Chang Liu, Zijun Zhou, Ye Chen, Ju Liu, Yang Wang, Hongsheng Liu
Scavenger receptor class B type 1 (SR-B1) is over-expressed in tumor cells where it mediates the uptake of drug payload of reconstituted high density lipoprotein (rHDL) via the process of reverse cholesterol transport. In this study, rHDL was prepared to determine its function as a drug delivery carrier for targeting hepatocellular carcinoma by incorporating the anti-tumor drug garcinia glycosides into rHDL to yield rHDL/GG nano-complexes. Structural analysis indicated that the rHDL/GG nano-complex was similar to HDL in size...
December 1, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29192510/aflatoxin-b1-detoxification-by-cell-free%C3%A2-extracts-of-rhodococcus-strains
#20
Anita Risa, Dalma Maja Divinyi, Erzsébet Baka, Csilla Krifaton
Aflatoxin B1 (AFB1) produced by Aspergillus molds is a genotoxic and carcinogenic mycotoxin. For the elimination of mycotoxins from food and feed, biodetoxification can be a successful tool. The aim of this study was to reveal biodetoxification with the cell-free extracts of Rhodococcus erythropolis NI1 and Rhodococcus rhodochrous NI2, which have been already proved to detoxify AFB1. Extracellular matrices of cultures and also intracellular extracts were applied for detoxification. In both cases, media containing constitutively produced and AFB1-induced enzymes were tested, respectively...
December 1, 2017: Acta Microbiologica et Immunologica Hungarica
keyword
keyword
45986
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"