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Ying Zhang, Hao Liu, Xinwei Shi, Fuyuan Qiao, Wanjiang Zeng, Ling Feng, Dongrui Deng, Haiyi Liu, Yuanyuan Wu
BACKGROUD: Widespread endothelial injury contributes to the occurrence of preeclampsia. Maspin, first identified as a tumor suppressor, plays a critical role in cell invasion and angiogenesis. Our previous studies found that the expression of maspin was increased in preeclampsic placenta. In this research, we studied the function of human umbilical vein endothelial cells (HUVECs) to explore the role and possible mechanism of maspin gene in the pathogenesis of preeclampsia. METHODS: HUVECs were treated with different concentration of recombinant human maspin protein (r-maspin) during normoxia and hypoxia, we detected the proliferation, apoptosis, migration and tube formation of HUVECs...
September 29, 2017: BMC Pregnancy and Childbirth
I Tagiyeva, S Aliyeva, S Bagirova, N Shamsadinskaya, K Agaeva
The pathophysiology of preeclampsia remains largely unknown. It has been hypothesized that placental ischemia is an early event, leading to placental production of a soluble factor or factors that cause maternal endothelial dysfunction, resulting in the clinical findings of hypertension, proteinuria, and edema. Here, we confirm that placental soluble fms-like tyrosine kinase 1 (sFlt1), an antagonist of vascular growth factor (VEGF) and placental growth factor (PIGF), is upregulated in preeclampsia, leading to increased systemic levels of sFlt1...
July 2017: Georgian Medical News
A H Aamir
Weight gain in pregnancy is physiological but if a woman is overweight prior to pregnancy, this will put both women and foetus at risk of adverse complications. Obesity can affect women at all the stages of pregnancy. Obese women can be a cause of reduced fertility as compared to a normal weight woman, and a typical example is of the Polycystic ovarian syndrome (PCOS). The incidence of Gestational Diabetes Mellitus ,hypertension and preeclamsia is 2-3 folds higher in obesity particularly with a BMI of> 30kg/m2...
September 2016: JPMA. the Journal of the Pakistan Medical Association
A H Aamir
Weight gain in pregnancy is physiological but if a woman is overweight prior to pregnancy, this will put both women and foetus at risk of adverse complications. Obesity can affect women at all the stages of pregnancy. Obese women can be a cause of reduced fertility as compared to a normal weight woman, and a typical example is of the Polycystic ovarian syndrome (PCOS). The incidence of Gestational Diabetes Mellitus ,hypertension and preeclamsia is 2-3 folds higher in obesity particularly with a BMI of> 30kg/m2...
September 2016: JPMA. the Journal of the Pakistan Medical Association
N Todorov
UNLABELLED: The preeclampsia is one of the most serious complications in the second half of the pregnancy with a high risk of perinatal maternal and neonatal mortality. The study is aiming to determine which pregnant women have a higher risk of developing preeclampsia with a view to the subsequent antenatal care, on the base of the individual factors. MATERIAL AND METODS: From prospectively followed pacients is collected information by a questionnaire and sonographic examination at 11-13 weeks of gestation/w...
2016: Akusherstvo i Ginekologii︠a︡
Vesna Livrinova, Marija Hadzi Lega, Anita Hristova Dimcheva, Igor Samardziski, Rozalinda Isjanovska
BACKGROUND: Factor V Leiden, Prothrombin and MTHFR gene mutation, could have an influence in pregnancy with adverse outcome Preeclamsia, IUGR and Placental abruption. AIM: The aim of this study is to investigate the presence of above mentioned inherited thrombophilias and its statistical significance, distribution among the complicated and normal pregnancy, and relative risk for carrier of mutation to develop preeclampsia, IUGR and placental abruption. MATERIAL AND METHODS: Prospective cohort study is implemented at University Clinic for Obstetric and Gynecology in Skopje, Republic of Macedonia...
December 15, 2015: Open Access Macedonian Journal of Medical Sciences
Hanzhi Wang, Linxiang Jiang, Bo Gao, Minyue Dong
BACKGROUND: Placental Semaphorin 3B (SEMA 3B) expression has been reported changed in preeclampsia and its possible involvement of in the disease proposed. We clarified the alterations of maternal SEMA 3B level in women suffering preeclampsia and pregnant women at gestational weeks of 16-20 before the onset of preeclampsia. METHODS: Serum SEMA 3B concentration was measured with ELISA in preeclamptic women (preeclampsia) and normotensive women (control) in 3rd trimester, and also in pregnant women at gestational weeks of 16-20 who developed preeclampsia or had favorable pregnant outcome...
April 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Alon Ben-David, Saralee Glasser, Eyal Schiff, Aliza Segev Zahav, Valentina Boyko, Liat Lerner-Geva
OBJECTIVES: In light of the potential physical and emotional costs to both woman and child, this study was conducted to assess pregnancy complications and birth outcomes in primiparae at very advanced maternal age (VAMA, aged ≥45) compared to younger primiparae. METHODS: Retrospective cohort study comparing 222 VAMA primiparae and a reference group of 222 primiparae aged 30-35, delivering at Sheba Medical Center from 2008 through 2013. RESULTS: VAMA primiparae were more likely than younger primiparae to be single, to have chronic health conditions, and higher rates of gestational diabetes mellitus (GDM), gestational-hypertension (GHTN) and preeclampsia-eclampsia...
April 2016: Maternal and Child Health Journal
Polona Žigon, Katja Perdan Pirkmajer, Matija Tomšič, Tanja Kveder, Borut Božič, Snežna Sodin Šemrl, Saša Čučnik, Aleš Ambrožič
Objective. To determine the prevalence and clinical association of anti-phosphatidylserine/prothrombin antibodies (aPS/PT) in patients with a history of pregnancy complications relevant to antiphospholipid syndrome (APS). Materials and Methods. Two hundred and eleven patients with a history of (a) three or more consecutive miscarriages before 10th week of gestation (WG) (n = 64), (b) death of a morphologically normal fetus beyond 10th WG (n = 72), (c) premature birth of a morphologically normal neonate before 34th WG due to eclampsia, preeclamsia and placental insufficiency (n = 33), and (d) less than three unexplained consecutive miscarriages before 10th WG (n = 42)...
2015: Journal of Immunology Research
S Iu Timokhova, V V Golubtsov, I B Zabolotskikh
OBJECTIVE: To improve treatment results of women with massive obstetrical blood loss. Subjects and methods: 96 female patients with average and heavy degree preeclampsia worsened massive blood developing were involved into the investigation. The women were divided into two groups: main (n=55) (basic) - it's patients were treated with complex of offered wiays control (n=41) - it's patients were evaluated retrospectively. During the investigation the parameters of hemostasis system and periphery blood values were performed as dynamic evaluations, acidity-basic state and water-electrolyte balance parameters, medical history were monitored...
November 2014: Anesteziologiia i Reanimatologiia
Qian Huang, Huishu Liu, Junjie Bao, Guozheng Zhang, Bihui Hu, Shaun Patrick Brennecke
OBJECTIVES: Eclampsia is an acute and life threatening multisystem disorder, which may predisposes the brain to edema formation and increase the electric activity of neurons. Aquaporin 4 (AQP4) can function as water-channels and aquaporin 9 (AQP9) as neutral channel. We hypothesized that these AQPs in brain are associated with the pathogenesis of preeclampsia and eclampsia. METHODS: To test this hypothesis, we used our previous eclampsia-like model and compared localization (immunohistochemistry, IHC), mRNA (QRT-PCR), and protein levels (Western analysis) of AQP4 and AQP9 in hippocampus from Sprague Dawley rats that were non-pregnant (NP), normal pregnant rats (P); preeclampsia rats (PE) and eclampsia-like rats (E)...
January 2015: Pregnancy Hypertension
L Seidmann, T Suhan, R Unger, V Gerein, C J Kirkpatrick
OBJECTIVE: Placental growth and villous maturation are critical parameters of placental function at the end of pregnancy. A failure in these processes leads to the development of placental dysfunction, as well as fetal and neonatal mortality and morbidity. The aim of the study was to determine the relevant diagnostic markers associated with pathological placental development. STUDY DESIGN: Forty tissue samples from normal placentas of different gestational age and 68 pathological term placentas with defective villous maturation (GDM, idiopathic IUFD, preeclamsia, HELLP syndrome) comprised the comparative immunohistochemical study (CD15, CD45 and CD34)...
September 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Kristy Red-Horse, Penelope M Drake, Susan Fisher
Susan Fisher has spent her career studying human development, proteomics, and the intersection between the two. When she began studying human placentation, there had been extensive descriptive studies of this fascinating organ that intertwines with the mother's vasculature during pregnancy. Susan can be credited with numerous major findings on the mechanisms that regulate placental cytotrophoblast invasion. These include the discovery that cytotrophoblasts undergo vascular mimicry to insert themselves into uterine arteries, the finding that oxygen tension greatly effects placentation, and identifying how these responses go awry in pregnancy complications such as preeclamsia...
2014: International Journal of Developmental Biology
Mehrangiz Ebrahimi-Mameghani, Esmat Mehrabi, Mahin Kamalifard, Parisa Yavarikia
BACKGROUND: The prevalence of obesity is increasing throughout the world.Obesity assessed by body mass index (BMI) has shown to be associated with gestational complications while the relationship using waist circumference (WC) is not clear yet. The present study was aimed to determine the relationship between WC and adverse pregnancy complications. METHODS: In this prospective cohort study, 1140 nulliparous pregnant women at 1st trimester of pregnancy referred to health care centers in Tabriz, Iran were enrolled in 2009-2010...
2013: Health Promotion Perspectives
A Khosrowbeygi, H Ahmadvand
The aim of the present study was to assess leptin/adiponectin ratio in preeclamptic patients compared with normal pregnant women. A cross-sectional study was designed. The study population consisted of 30 preeclamptic patients and 30 healthy pregnant women. Serum levels of total leptin and adiponectin were assessed using commercially available enzyme-linked immunosorbent assay methods. The one-way ANOVA and Student's t tests and Pearson's correlation analysis were used for statistical calculations. Levels of leptin and adiponectin were also adjusted for BMI...
April 2013: Bangladesh Medical Research Council Bulletin
Elena Fridman, Nehama Linder
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that occurs in premature infants who have needed mechanical ventilation and oxygen therapy. BPD is defined as the presence of persistent respiratory symptoms, the need for supplemental oxygen to treat hypoxemia, and an abnormal chest radiograph at 36 weeks gestational age. Proinflammatory cytokines and altered angiogenic gene signaling impair prenatal and postnatal lung growth, resulting in BPD. Postnatal hyperoxia exposure further increases the production of cytotoxic free radicals, which cause lung injury and increase the levels of proinflammatory cytokines...
March 2013: Harefuah
Shohreh Malek-Khosravi, Zohreh Rahimi, Ziba Rahimi, Faranak Jalilvand, Abbas Parsian
The aim of the present study was to investigate the frequency and the possible association between thrombophilic mutations of factor V Leiden (FVL) and prothrombin G20210A with preeclampsia among Kurdish population of Western Iran. We studied 198 women with preeclampsia including 128 women with mild and 70 women with severe forms and 101 healthy pregnant women with uncomplicated pregnancy. Among cases there were 23 women with early onset preeclampsia and 175 cases with late-onset preeclampsia. The sample was genotyped by polymerase chain reaction-restriction fragment-length polymorphism using Mnl I and Hind III for FVL and prothrombin G20210A, respectively...
January 2012: Journal of Thrombosis and Thrombolysis
Narges Moslemizade, Alireza Rafiei, Fereshteh Yazdani, Zahra Hosseini-khah, Keyvan Yusefnezhad
UNLABELLED: Preeclampsia is a disease regarding with altered vascular reactivity leading to hypertension of the mother and metabolic alterations in the fetus. This study aimed to assess nitric oxide and bleeding time following administration of magnesium sulfate to preeclamtic patients compared to normotensive pregnant women. A total of 112 subjects (56 preeclamtic patients and 56 normotensive pregnant controls) were enrolled in this case-control study. Cases and controls were matched for age, BMI, gestational age, parity and gravidity...
January 15, 2011: Pakistan Journal of Biological Sciences: PJBS
A A Zhurova, A V Ekstrem, A S Popov
The method of long-term continuous low-volume infusion of hydroxyethyl starch (low-flow low volume correction HES) is administrated for correction of fluid balance disorders. The method is aimed to improve the outcomes in preeclamsia patients with multiple organ dysfunction and failure, as the most severe manifestation of system inflammatory response syndrome. After 4 days of the intensive care with application of the developed method in patients with preeclamsia the total body water level is decreased to the normal physiological level, the oedemas are significantly reduced or ceased, the haemodynamics stabilizes, which leads to the reduce of neurologic symptoms...
November 2010: Anesteziologiia i Reanimatologiia
Naira Roland Matevosyan
PURPOSE: To elucidate plausible associations between periodontal disease (PD) and pregnancy events through meta-analysis of original research published between 1998 and 2010. METHODS: One hundred and twenty-five randomized, case-control, matched-cohort studies on pregnancy and postpartum specifics in women with PD are identified through PubMed, LILACS, and Cochrane Register. Meta-study is performed on a sample of 992 births allocated from studies of level I-II-1 evidence...
April 2011: Archives of Gynecology and Obstetrics
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