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Ming-Qiu Shan, Yan Qian, Sheng Yu, Shu-Chen Guo, Li Zhang, An-Wei Ding, Qi-Nan Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Schizonepeta tenuifolia Briq. (ST) herbs have been used as a Traditional Chinese Medicine (TCM) for treating colds for thousands of years. The volatile oil is considered as the main material basis responsible for the efficacy of ST and has attracted lots of attention on its anti-inflammatory effect recently. AIM OF STUDY: This paper investigated the anti-inflammatory effects of the distilled volatile oils from Schizonepeta tenuifolia (STVO) that were collected at different harvesting times on carrageenin-induced pleurisy in rats...
December 24, 2016: Journal of Ethnopharmacology
Ju-Young Kim, Jong Min Baek, Sung-Jun Ahn, Yoon-Hee Cheon, Sun-Hyang Park, Miyoung Yang, Min Kyu Choi, Jaemin Oh
BACKGROUND: Excessive osteoclast activity is a major cause of metabolic bone disorders, such as osteopenia, rheumatoid arthritis, and osteoporosis. Thus, discovery of agents targeting osteoclast differentiation and bone resorption is important for development of novel treatments for bone diseases. It has been demonstrated that ethanolic extract of schizonepeta tenuifolia (EEST) has potent anti-oxidant and anti-inflammatory activities. However, the beneficial effects of EEST on bone metabolism have not been studied...
August 22, 2016: BMC Complementary and Alternative Medicine
X W Song, G Y Li, D Q Wang, B X Han
Herba Schizonepetae was firstly recorded in the Sheng nong ben caojing (Shennong's Materia Medica) with the title Jiasu. It could be sure that the original plant of Jiasu is Ocimumbasilicum L. ofLabiatae based on the record of Jiasu's name, morphology, edible property before the Song Dynasty. Beginning from the Ben cao tu jing (Illustrated Classic of Materia Medica) in the Song Dynasty, the source of this drug evolved as SchizonepetatenuisfoliaBriq. ofLabiatae, and it has been in use until now. Hence, the sources of Jiasu should be both O...
May 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
Li-Zi Zhao, Yue Jin, Xiao-Min Han, Qing-Long Chu, Jun-Shan Yang
Two new sesquiterpenes named petafolias A-B were isolated from the aerial parts of Schizonepeta tenuifolia. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, CD, 1D, and 2D NMR).
June 7, 2016: Journal of Asian Natural Products Research
Yachun Shu, Yajun Chen, Kunming Qin, Xiao Liu, Baochang Cai
BACKGROUND: Yinqiaosan (Lonicerae and Forsythiae Powder), as a famous prescription of Dr. Wu Jutong in Qing dynasty of China, has the effects of diaphoresis cooling, fire-purging, and detoxicaton. It is mainly used in the treatment of influenza, hand-foot-mouth disease, esophagitis, pneumonia, acute tonsillitis, mumps, and other viral infections. It is one of the widely used traditional Chinese medicine prescriptions with proven curative effects in clinical use. OBJECTIVE: To research the material basis of Yinqiaosan decoction when decocting mint, herba schizonepetae in different length of later-decoction time, to find the influence on volatile components of Yinqiaosan decoction decocted later in different length of time, to lay the foundation to further clarify the after-decoction mechanism of Yinqiaosan, and the specification of Yinqiaosan decoction process...
April 2016: Pharmacognosy Magazine
Ying-Ju Lin, Tsung-Jung Ho, Ting-Hsu Lin, Wei-Yi Hsu, Shao-Mei Huang, Chiu-Chu Liao, Chih-Ho Lai, Xiang Liu, Hsinyi Tsang, Chien-Chen Lai, Fuu-Jen Tsai
BACKGROUND: Wilson's disease (WD) is a genetic disorder involving the metabolism of copper. WD patients exhibit a wide range of disease phenotypes, including Kayser-Fleischer rings in the cornea, predominant progressive hepatic disease, neurological diseases, and/or psychiatric illnesses, among others. Patients with exon12 mutations of the ATP7B gene have progressive hepatic disease. An ATP7B gene that lacks exon12 retains 80% of its copper transport activities, suggesting that alternative splicing of ATP7B gene may provide alternative therapeutic ways for patients with inherited sequence variants and mutations of this gene...
June 2015: BioMedicine
Yukari Sunohara, Yohei Baba, Shigeru Matsuyama, Kaori Fujimura, Hiroshi Matsumoto
Screening and identification of phytotoxic volatile compounds were performed using 71 medicinal plant species to find new natural compounds, and the characterization of the promising compound was investigated to understand the mode of action. The volatile compounds from Asarum sieboldii Miq. showed the strongest inhibitory effect on the hypocotyl growth of lettuce seedlings (Lactuca sativa Great Lakes 366), followed by those from Schizonepeta tenuifolia Briquet and Zanthoxylum piperitum (L.) DC.. Gas chromatography-mass spectrometry (GC/MS) identified four volatile compounds, α-pinene (2,6,6-trimethylbicyclo[3...
July 2015: Protoplasma
Li-Xia Yu, Ming-Qiu Shan, An-Wei Ding
In this experiment, the HPLC specific chromatogram was adopted, with Agilent Extend-C18 (4.6 mm x 250 mm, 5 microm) as the chromatographic column, and 0.5 per thousand trifluoroacetic acid and acetonitrile as the mobile phase for gradient elution, so as to establish specific chromatograms for drug pair of Schizonepetae Herba and Saposhnikoviae Radix from different producing area, identify 12 common characteristic peaks, and obtain the comparison specific chromatography of drug pair of Schizonepetae Herba and Saposhnikoviae Radix...
February 2014: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ming-Qiu Shan, Sheng Yu, Li-Xia Yu, An-Wei Ding
UNLABELLED: To study the main storage organ of each mineral element in Schizonepeta tenuifolia, and explain its reasonable harvesting time and medicinal parts in view of mineral elements. The mineral elements of Schizonepeta tenuifolia in different organs at different harvesting times were determined by ICP-AES technique. The mineral elements, K, Ca, Na, P, Mg, Mn, Zn, Cu, Fe, Mo, were determined in the study. The results showed that at different harvesting times, (1) the contents of K, P, Cu in fringe and the contents of Mg, Ca, Na, Fe, Mn, Zn in leaf were highest among different organs...
February 2014: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
Myung-Woo Byun
Inflammatory diseases remain the leading cause of mortality worldwide in both men and women. Schizonepeta tenuifolia (ST) exerts a wide range of physiological activities and has been found to possess beneficial efficacies against inflammation-related diseases; however, the molecular mechanisms underlying this anti-inflammatory activity remain to be elucidated. We investigated the molecular basis for the downregulation of toll-like receptor 4 (TLR4) signal transduction by ST ethanol extract in lipopolysaccharide (LPS)-stimulated macrophages...
March 2014: Journal of Medicinal Food
Yoichiro Isohama
No abstract text is available yet for this article.
March 2014: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Wen-Ling Fan, Li-Wei Guo, Ying Lin, Yun Zhu, Min Xu, Lei Yang, Rong-Rong Zhu, Yan-Fei Li
Membrane enrichment process of Chinese medicine volatile oil is green, practical and has a good application prospects. Schizonepetae Herba et al. six chinese medicine oily water were filtrated with polyvinylidene fluoride (PVDF) membrane with MWCO 70 000, at 40 degrees C, 0.1 MPa and 150 r x min(-1), common laws of physicochemical property of six oily water and fingerprint similarity between original and preserved oil were studied during membrane enrichment. Results were as follows: pH was gradually reduced to the minimum; conductivity firstly became larger, then smaller until 0; viscosity gradually increased to a maximum; surface tension gradually decreased to a minimum; turbidity firstly gradually increased, then reduced to a minimum; density gradually decreased to a minimum, but the change trend was opposite for Acori Tatarinowii Rhizoma with heavy oil; salinity was 0...
October 2013: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Wen-Ling Fan, Li-Wei Guo, Ying Lin, Jie Shen, Gui-Ping Cao, Yun Zhu, Min Xu, Lei Yang
The membrane enrichment process of traditional Chinese medicine volatile oil is environmental friendly and practical, with a good application prospect. In this article, oil-bearing solutions of eight traditional Chinese medicines, namely Caryophylli Flos, Schizonepetae Herba, Eupatorii Herb, Acori Talarinowii Rhizoma, Magnoliae Flos, Chrysanthemum indicum, Cyperi Rhizoma and Citri Reticulatae Pericarpium Viride, were taken as the experimental system. Under unified conditions (membrane: PVDF-14W, temperature: 40 degreeC, pressure: 0...
October 2013: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Do Young Kwon, Sun Ju Kim, Ju Won Lee, Young Chul Kim
The ability of 80% ethanol extracts from five medicinal plants, Aralia continentalis, Paeonia suffruticosa, Magnolia denudata, Anemarrhena asphodeloides, and Schizonepeta tenuifolia, to neutralize hydroxyl radical, peroxyl radical and peroxynitrite was examined using the total oxyradical scavenging capacity (TOSC) assay. Peroxyl radical was generated from thermal homolysis of 2,2'-azobis (2-methylpropionamidine) dihydrochloride (ABAP) ; hydroxyl radical by an iron-ascorbate Fenton reaction; peroxynitrite by spontaneous decomposition of 3-morpholinosydnonimine N-ethylcarbamide (SIN-1) ...
December 2010: Toxicological Research
Ji-Yeon Yang, Hoi-Seon Lee
The acaricidal potential of an active constituent isolated from Schizonepeta tenuifolia oil and its structurally related derivatives was evaluated using filter paper and impregnated cotton fabric disk bioassays against house dust and stored food mites. The acaricidal constituent of S. tenuifolia oil was isolated by chromatographic techniques and identified as 2-isopropyl-5-methylcyclohexanone by GC-MS, (1)H-, and (13)C NMR spectra. 2-Isopropyl-5-methylcyclohexanone was a potent acaricide against house dust and stored food mites, based on the LD50 values from the filter paper and impregnated cotton fabric disk bioassays, followed by 4-isopropylcyclohexanone, 2-isopropylidene-5-methylcyclohexanone, 2-methylcyclohexanone, 3-methylcyclohexanone, 4-methylcyclohexanone, and benzyl benzoate...
November 27, 2013: Journal of Agricultural and Food Chemistry
Ting He, Qi Tang, Nan Zeng, Ling Gou, Jin-Wei Liu, Jing Yang, Liu Yu, Zhe Wang, Xi-Ping Gong
OBJECTIVE: To observe the effect of volatile oil of Schizonepetae Herba (VOSH), and its essential components-menthone and pulegone against anti-influenza virus A/PR/8/34 (H1N1) in vivo and in vitro, as well as the signaling mechanism of its toll-like receptor/interferon (TLR/IFN). METHOD: The lung-adapted PR-8 virus model was prepared in mice. They were administered with preventive and therapeutic drugs, and the hemagglutination titer of model animals was determined to evaluate in vivo effect against H1N1...
June 2013: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
H Wu, C C Fu, D D Yu, J T Feng, X Zhang, Z Q Ma
BACKGROUND: The main ingredient of most repellents on the market is DEET, an effective compound that has the disadvantages of toxic reactions as well as damaging effects on plastic and synthetic fabric. DEET alternatives are urgently needed. METHODS: The repellent activities of 11 kinds of essential oils were tested against Aedes albopictus Skuse by a Y-tube olfactometer. Using essential oils with high repellent activity as core material and gelatin and gum arabic as wall materials, we prepared microcapsules of essential oils and optimized the preparation process...
August 2013: Transactions of the Royal Society of Tropical Medicine and Hygiene
Yan Liang, Jin Lu Li, Shuai Xu, Na Na Zhao, Ligang Zhou, Jun Cheng, Zhi Long Liu
The screening for repellency against the booklouse, Liposcelis bostrychophila (Badonnel), and the red flour beetle, Tribolium castaneum (Herbst), from 14 Chinese medicinal herbs showed that the essential oils of Curcuma longa L., Epimedium pubescens Maximouwicz, Lindera aggregate (Sims) Kostermans, Nardostachys chinensis Battandier, Schizonepeta tenuifolia Briquet, Zanthoxylum schinifolium Sieber et Zuccarini, and Z. officinale Roscoe exhibited strong repellency against L. bostrychophila and T. castaneum. A total of 35 components of the essential oil of E...
February 2013: Journal of Economic Entomology
Chang-Qin Li, Jin-Mei Wang, Wen-Yi Kang
OBJECTIVE: To study the validity of Schizonepeta tenuifalia pieces. METHOD: The change principle for the contents of essential oil and pulegone was determined by the way of classical constant temperature acceleration experiment, and the reacting speed at 20 degrees C was calculated according to Arrhenius index law and effective time was calculated. RESULT: In classical constant temperature experiment, the content change of essential oil with the regular pattern of one level...
November 2012: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
You Yeon Choi, Mi Hye Kim, Jong-Hyun Kim, Hyuk-Sang Jung, Youngjoo Sohn, Young Jin Choi, Man Ki Hwang, Sung-Hoon Kim, Jinju Kim, Woong Mo Yang
Historically, Schizonepeta tenuifolia (ST) has been used for the treatment of skin disorders, such as allergic dermatitis, eczema, and inflammatory diseases. In this study, we examined whether ST inhibited 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in BALB/c mice. In histopathological analyses of the epidermis and dermis, skin thickness was significantly increased in DNCB-induced mice as compared with normal group. Treatment with ST inhibited this inflammatory change and markedly suppressed the secretion of immunoglobulin E, tumor necrosis factor α, and interleukin 6 levels in the serum of DNCB-induced mice...
August 2013: Phytotherapy Research: PTR
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