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Animesh Mondal, Barnali Naskar, Sanchita Goswami, Chandraday Prodhan, Keya Chaudhuri, Chhanda Mukhopadhyay
An easy access to an amine-appended spiro[indoline-3,4'-pyridine] ON-OFF chemosensor by a one-pot four-component reaction using commercially available and an environmentally benign catalytic amount of molecular I2 (10 mol%) in aqueous ethanol at ambient temperature is described. The generated system could be utilized for the selective detection of Cu2+ as it demonstrated a colorimetric naked eye change along with an ON-OFF fluorescence response towards Cu2+ at physiological pH. The sensors exhibited high selectivity for Cu2+ over other common cations with detection limit in the range of 10-7 (M)...
December 15, 2017: Organic & Biomolecular Chemistry
Katherine T Baum, Christian von Thomsen, Megan Elam, Christel Murphy, Melissa Gerstle, Cynthia A Austin, Dean W Beebe
OBJECTIVE: The neuropsychological report is a critical tool for communicating evaluation results to multiple audiences who have varying knowledge about neuropsychology and often have limited ability to review long, complex reports. Considerable time is spent writing these reports and challenges persist related to readability, length/complexity, and billable clinical time (which may be capped by third-party payors or families' ability to pay). METHODS: This quality improvement effort systematically evaluated the redesign of pediatric neuropsychological reports in an outpatient clinic serving primarily medical populations...
December 15, 2017: Clinical Neuropsychologist
Ryo Sekiya, Alejandro Díaz-Moscoso, Pablo Ballester
We describe the syntheses of the lipophilic aryl-extended α,α,α,α-tetraurea-phenyl-calix[4]pyrrole 1, featuring four appended azo-phenyl groups with two tert-butoxy carbonyl meta-substituents and its photo-inactive counterpart 2. In CD₂Cl₂ solutions, both tetraurea-calix[4]pyrroles self-assemble into dimeric capsules by encapsulating one molecule of a suitable bis-N-oxides or two molecules of a mono-N-oxide. The dimeric capsules are mainly stabilized by a cyclic array of sixteen hydrogen bonds stablished between the eight unidirectionally oriented urea groups...
December 15, 2017: Chemistry: a European Journal
E W Dahl, H T Dong, N K Szymczak
A series of copper complexes bearing new 6-substituted tris(2-pyridylmethyl)amine ligands (LR) appended with NH(p-R-C6H4) groups (R = H, CF3, OMe) were prepared. These ligands are electronically tunable (ΔE1/2 = 160 mV) and CuI(LR)+ complexes react with oxygen to form hydrogen bonded (trans-1,2-peroxo)dicopper species.
December 15, 2017: Chemical Communications: Chem Comm
Thejasvi Subramanian, Ellen Jerome, Ian Jones, Ingo Jester
AIM OF STUDY: Streptococcus anginosus group (SA) (formerly Streptococcus milleri) are pathogens recognised to have a high risk of postoperative collection in appendicitis, although little data exist specifically in children. We performed a retrospective review of all microbiological data from appendicectomies to assess whether there was an association in children. METHODS: A retrospective case note review of patients admitted to a paediatric tertiary centre coded for appendicitis from January 2015 to October 2016 was completed...
November 12, 2017: Journal of Pediatric Surgery
Heather L Short, Samir Sarda, Curtis Travers, Jason M Hockenberry, Ian McCarthy, Mehul V Raval
PURPOSE: Though growth in children's surgical expenditures has been documented, procedure-specific differences in volume and costs at children's hospitals (CH) and non-hildren's hospitals (NCH) have not been explored. Our purpose was to compare trends in volume and costs of common pediatric surgical procedures between CH and NCH. METHODS: We performed a review of the 2000-2009 Kids' Inpatient Database identifying all cases of appendectomy for uncomplicated appendicitis (AP), tonsillectomy and adenoidectomy (TA), fundoplication (FP), humeral fracture repair (HFR), pyloromyotomy (PYL), and cholecystectomy (CHOLE)...
November 23, 2017: Journal of Pediatric Surgery
Danielle B Cameron, Regan Williams, Yimin Geng, Ankush Gosain, Meghan A Arnold, Yigit S Guner, Martin L Blakely, Cynthia D Downard, Adam B Goldin, Julia Grabowski, Dave R Lal, Roshni Dasgupta, Robert Baird, Robert L Gates, Julia Shelton, Tim Jancelewicz, Shawn J Rangel, Mary T Austin
OBJECTIVE: The goal of this systematic review by the American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee was to develop recommendations regarding time to appendectomy for acute appendicitis in children within the context of preventing adverse events, reducing cost, and optimizing patient/parent satisfaction. METHODS: The committee selected three questions that were addressed by searching MEDLINE, Embase, and the Cochrane Library databases for English language articles published between January 1, 1970 and November 3, 2016...
November 20, 2017: Journal of Pediatric Surgery
Josef Maertz, Jan Philip Kolb, Thomas Klein, Kathrin J Mohler, Matthias Eibl, Wolfgang Wieser, Robert Huber, Siegfried Priglinger, Armin Wolf
PURPOSE: To demonstrate papillary imaging of eyes with optic disc pits (ODP) or optic disc pit associated maculopathy (ODP-M) with ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s. To generate 3D-renderings of the papillary area with 3D volume-reconstructions of the ODP and highly resolved en face images from a single densely-sampled megahertz-OCT (MHz-OCT) dataset for investigation of ODP-characteristics. METHODS: A 1...
December 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
Holm Petzold, Paul Djomgoue, Gerald Hörner, Charles Lochenie, Birgit Weber, Tobias Rüffer
A series of Fe2+ SCO complexes of substituted 2-(pyridin-2-yl)-1,10-phenanthrolines 2 was prepared and the SCO (spincrossover) properties were characterized in the solid state (X-ray crystallography, SQUID magnetometry) and in solution (VT-1H NMR spectroscopy), augmented by theoretical modelling. Bis-meridional coordination of the tridendate 2a-c and tetradentate 2d ligands gives octahedral and distorted trigonal-dodecahedral complexes [Fe(2)2]2+, respectively, which were identified as SCO complexes with the transition temperature T1/2 below room temperature...
December 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Kilingaru I Shivakumar, Goudappagouda, Rajesh G Gonnade, Sukumaran Santhosh Babu, Gangadhar J Sanjayan
We report a novel set of easily tailorable C3 symmetric molecules with a π-extended core and adorned with different thioalkyl groups, exhibiting solvatofluorochromic and amphoteric redox behaviour. The nearly planar core exhibits intermolecular face-to-face π-stacking, SS and intramolecular SO interactions. Current-sensing atomic force microscopy studies revealed a high conductivity of ∼0.15 mS cm-1 in the undoped J-aggregate nanofibres of the thiopropyl appended gelator.
December 12, 2017: Chemical Communications: Chem Comm
Michelle J Hong, Lauren M Porter, Debra D Esernio-Jenssen, Andrew C Miller, Marna Rayl Greenberg
Pediatric pancreatic injuries are rare. We present an atypical case that occurred in a 4-year-old male. The child presented with a twenty-four-hour history of vomiting that had progressed to right lower quadrant abdominal pain on examination in the emergency department. The initial differential was gastroenteritis versus appendicitis. An abnormality on the ultrasonography and an elevated lipase level eventually led to an MRI showing a complete transection through the posterior margin of the pancreas. The patient was admitted to pediatric surgery and underwent a successful distal pancreatectomy with preservation of the spleen...
2017: Case Reports in Pediatrics
Emmanuel Katsogridakis, Goran Pokusevski, Peter Byrne
Amyand's hernia (AH) is characterized by the presence of the vermiform appendix in an inguinal hernia sac. Typically presenting on the right side and with manifestations similar to those seen in complicated hernias, it presents a diagnostic challenge and is frequently only diagnosed intraoperatively. We present the case of a left-sided AH on a 75-year-old man treated with appendicectomy, orchidectomy and hernioplasty without mesh.
November 2017: Journal of Surgical Case Reports
Muhammad Sohaib Khan, Mustafa Belal Hafeez Chaudhry, Noman Shahzad, Marvi Tariq, Wasim Ahmed Memon, Abdul Rehman Alvi
BACKGROUND: An appendicolith-related appendiceal obstruction leading to appendicitis is a commonly encountered surgical emergency that has clear evidence-based management plans. However, there is no consensus on management of asymptomatic patients when appendicoliths are found incidentally. The objective of this study was to determine the risk of appendicitis in patients with an incidental finding of the appendicolith. METHODS: A retrospective matched cohort study of patients with appendicolith discovered incidentally on computed tomographic scan from January 2008 to December 2014 at our institution was completed...
January 2018: Journal of Surgical Research
Andrew B Nordin, Stephen Sales, Jason W Nielsen, Brent Adler, David Gregory Bates, Brian Kenney
BACKGROUND: Ultrasound is preferred over computed tomography (CT) for diagnosing appendicitis in children to avoid undue radiation exposure. We previously reported our experience in instituting a standardized appendicitis ultrasound template, which decreased CT rates by 67.3%. In this analysis, we demonstrate the ongoing cost savings associated with using this template. METHODS: Retrospective chart review for the time period preceding template implementation (June 2012-September 2012) was combined with prospective review through December 2015 for all patients in the emergency department receiving diagnostic imaging for appendicitis...
January 2018: Journal of Surgical Research
Clive L Baveghems, Murali Anuganti, Ajith Pattammattel, Yao Lin, Challa V Kumar
Using glucose oxidase (GOx) and α-Zr(IV)phosphate nanoplates (α-ZrP) as a model system, a generally applicable approach to control enzyme-solid interactions via chemical modification of amino acid side chains of the enzyme is demonstrated. Net charge on GOx was systematically tuned by appending different amounts of polyamine to the protein surface to produce chemically modified GOx(n), where n is the net charge on the enzyme after the modification and ranged from -62 to +95 electrostatic units in the system...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Anne Hoffmann, Jörg Fallmann, Mario Mörl, Peter F Stadler, Fabian Amman
Motivation: Many repetitive DNA elements are transcribed at appreciable expression levels. Mapping the corresponding RNA sequencing reads back to a reference genome is notoriously difficult and error-prone task, however. This is in particular true if chemical modifications introduce systematic mismatches, while at the same time the genomic loci are only approximately identical, as in the case of tRNAs. Results: We therefore developed a dedicated mapping strategy to handle RNA-seq reads that map to tRNAs relying on a modified target genome in which known tRNA loci are masked and instead intronless tRNA precursor sequences are appended as artificial "chromosomes"...
December 8, 2017: Bioinformatics
John J Kiernicki, Matthias Zeller, Nathaniel K Szymczak
Incorporation of two 9-borabicyclo[3.3.1]nonyl substituents within the secondary coordination sphere of a pincer-based Fe(II) complex provides Lewis acidic sites capable of binding 1 or 2 equiv of N2H4. Reduction of the 1:1 Fe:N2H4 species affords a rare Fe(NH2)2 complex in which the amido ligands are stabilized through interactions with the appended boranes. The NH2 units can be released as NH3 upon protonation and exchanged with exogenous N2H4.
December 11, 2017: Journal of the American Chemical Society
Daiki Kashiwagi, Seunghyun Sim, Tatsuya Niwa, Hideki Taguchi, Takuzo Aida
Here we report molecular chaperone GroELs that carry, at their apical domains, multiple DNA strands (ideally 28 DNA strands in total) with defined oligonucleotide (nt) sequences. This design strategy allows for the preparation of GroEL10a and GroEL10b carrying 10-nt DNA strands of 10a and 10b with complementary sequences, respectively, at their apical domains (Table 1). One-dimensional coassembly of these GroELs is possible to form protein nanotube NT10a/10b with an anomalous thermodynamic stability due to the exceptionally large multivalency for the coassembly...
December 11, 2017: Journal of the American Chemical Society
Josef A Gramespacher, Adam J Stevens, Robert E Thompson, Tom W Muir
Naturally split inteins mediate a traceless protein ligation process known as protein trans-splicing (PTS). Although frequently used in protein engineering applications, the efficiency of PTS can be reduced by the tendency of some split intein fusion constructs to aggregate; a consequence of the fragmented nature of the split intein itself or the polypeptide to which it is fused (the extein). Here, we report a strategy to help address this liability. This involves embedding the split intein within a protein sequence designed to stabilize either the intein fragment itself or the appended extein...
December 11, 2017: Protein Science: a Publication of the Protein Society
Thomas E Pennington, Jade F Enoch, Davendra Segara
No abstract text is available yet for this article.
December 10, 2017: ANZ Journal of Surgery
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