keyword
MENU ▼
Read by QxMD icon Read
search

appenditis

keyword
https://www.readbyqxmd.com/read/29450416/a-g-quadruplex-motif-at-the-3-end-of-sgrnas-improves-crispr-cas9-based-genome-editing-efficiency
#1
Smita Nahar, Paras Sehgal, Mohd Azhar, Manish Rai, Amrita Singh, Sridhar Sivasubbu, Debojyoti Chakraborty, Souvik Maiti
Originating as a component of prokaryotic adaptive immunity, the type II CRISPR/Cas9 system has been repurposed for targeted genome editing in various organisms. Although Cas9 can bind and cleave DNA efficiently under in vitro conditions, its activity inside a cell can vary dramatically between targets owing to the differences between genomic loci and the availability of enough Cas9/sgRNA (single guide RNA) complex molecules for cleavage. Most methods have so far relied on Cas9 protein engineering or base modifications in the sgRNA sequence to improve CRISPR/Cas9 activity...
February 16, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29441616/augmenting-photoinduced-transport-in-a-single-component-gel-system-through-room-temperature-controlled-in-situ-gel-crystal-transformation
#2
Sitakant Satapathy, Palani Prabakaran, Edamana Prasad
Smart single component materials with versatile functions requires pre-programming of a higher order molecular assembly. The contribution here introduces an electroactive supergelator (c = 0.07 wt%), i.e., triphenyl amine core appended poly(aryl ether) dendron (TPAPAE), where the substantial dendritic effect improves the order and crystallinity by switching the local minimum from self-assembled molecular wires to thermodynamically favourable global minimum of ordered crystals, ripened within the fibers. Controlled in situ phase change at room temperature ultimately stabilized the mixed valence states in the single component supramolecular assembly with an amplified photoluminescence and photoinduced charge transport by two orders of magnitude...
February 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29439578/guest-back-folding-a-molecular-design-strategy-that-produces-a-deep-red-fluorescent-host-guest-pair-with-picomolar-affinity-in-water
#3
Wenqi Liu, Andrew Johnson, Bradley D Smith
One of the major goals of modern supramolecular chemistry, with important practical relevance in many technical fields, is the development of synthetic host/guest partners with ultrahigh affinity and selectivity in water. Currently, most association pairs exhibit micromolar affinity or weaker, and there are very few host/guest systems with Ka > 109 M-1, apparently due to a barrier imposed by enthalpy/entropy compensation. This present study investigated the threading of a water-soluble tetralactam cyclophane by a deep-red fluorescent squaraine guest with flanking polyethyleneglycol chains, an association process that is dominated by a highly favorable enthalpic driving force...
February 13, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29438133/accuracy-of-ultrasound-exam-performed-by-emergency-medicine-versus-radiology-residents-in-the-diagnosis-of-acute-appendicitis
#4
Marzieh Shahbazipar, Javad Seyedhosseini, Elnaz Vahidi, Hojat Sheikh Motahar Vahedi, Amirhossein Jahanshir
BACKGROUND: Although the traditional approach to the diagnosis of acute appendicitis (AA) is using clinical methods, experience has shown that strict reliance on clinical data can lead to mismanagement or unnecessary surgery. OBJECTIVE: The objective of this study was to determine the total agreement of ultrasound (US) results in AA performed by emergency medicine (EM) versus radiology residents in emergency department. PATIENTS AND METHODS: In this cross-sectional study, 121 patients with AA suspicion underwent an US exam by both trained EM and radiology residents in emergency department...
February 12, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29435552/mild-and-selective-pd-ar-protonolysis-and-c-h-activation-promoted-by-a-ligand-aryloxide-group
#5
Ava Behnia, Mahmood A Fard, Johanna M Blacquiere, Richard J Puddephatt
A bidentate nitrogen-donor ligand with an appended phenol group, C5H4NCH[double bond, length as m-dash]N-2-C6H4OH, H(L1) was treated with a palladium cycloneophyl complex [Pd(CH2CMe2C6H4)(COD)], with both Pd-aryl and Pd-alkyl bonds, to give a Pd-alkyl complex, [Pd(CH2CMe2C6H5)(κ3-N,N',O-OC6H4N[double bond, length as m-dash]CH(2-C5H4N))], 1. The cleavage of the Pd-aryl bond and the deprotonation of the ligand phenol to afford a bound aryloxide, indicates facile Pd-aryl bond protonolysis. Deuterium labelling experiments confirmed that the ligand phenol promotes protonolysis and that the reverse, aryl C-H activation, occurs under very mild reaction conditions (within 10 min at room temperature)...
February 13, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29433399/death-caused-by-appendicular-knotting-and-small-bowel-strangulation-in-a-child-a-case-report-and-review
#6
Andres Rodriguez Zorro, Jairo Hernando Vivas Diaz
Acute appendicitis is one of the most common surgical emergencies in paediatrics. However, acute appendicitis in early infancy is an uncommon condition. Furthermore, strangulation of the small intestine through appendicular knotting is described as very unusual in the literature and is generally not well-diagnosed in the clinical context. This article reports the case of a 23-month-old girl who entered the emergency department with a three-day history of abdominal symptoms and who died in less than 24 hours without receiving surgical intervention...
January 1, 2018: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/29431586/drain-failure-in-intra-abdominal-abscesses-associated-with-appendicitis
#7
Christopher B Horn, Adrian A Coleoglou Centeno, Jarot J Guerra, John E Mazuski, Grant V Bochicchio, Isaiah R Turnbull
BACKGROUND: Previous studies have suggested that percutaneous drainage and interval appendectomy is an effective treatment for appendicitis with associated abscess. Few studies to date have analyzed risk factors for failed drain management. We hypothesized that older patients with more co-morbidities would be at higher risk for failing conservative treatment. METHODS: The 2010-2014 editions of the National Inpatient Sample (NIS) were queried for patients with diagnoses of peri-appendiceal abscesses...
February 12, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29428963/efficacy-of-strain-elastography-in-diagnosis-and-staging-of-acute-appendicitis-in-pediatric-patients
#8
Harun Arslan, Zülküf Akdemir, Alpaslan Yavuz, Fahri Gökçal, Cemal Parlakgümüş, Necat İslamoglu, Hüseyin Akdeniz
BACKGROUND In the present study, the role and efficiency of strain elastography (SE) were evaluated in diagnosis and staging of acute appendicitis in pediatric patients. MATERIAL AND METHODS We enrolled 225 pediatric patients with suspected clinical and laboratory findings of acute appendicitis. Gray-scale sonographic findings were recorded and staging was made by the colorization method of SE imaging. Appendectomy was performed in all patients and the results of the surgical pathology were compared with the imaging findings...
February 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29427374/economic-analysis-of-diagnostic-imaging-in-pediatric-patients-with-suspected-appendicitis
#9
Anupam B Kharbanda, Eric W Christensen, Nanette C Dudley, Lalit Bajaj, Michelle D Stevenson, Charles G Macias, Manoj K Mittal, Richard G Bachur, Jonathan E Bennett, Kelly Sinclair, Brianna McMichael, Peter S Dayan
OBJECTIVE: The use of computed tomography (CT) and ultrasound (US) in patients with acute abdominal pain has substantial variation across pediatric emergency departments (ED). This study compares the cost of diagnosing and treating suspected appendicitis across a multi-center network of children's hospitals. METHODS: This study is a secondary analysis using de-identified data of a prospective, observational study of patients with suspected appendicitis at nine pediatric EDs...
February 10, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29426650/the-ripasa-score-for-the-diagnosis-of-acute-appendicitis-a-comparison-with-the-modified-alvarado-score
#10
C Z Díaz-Barrientos, A Aquino-González, M Heredia-Montaño, F Navarro-Tovar, M A Pineda-Espinosa, I A Espinosa de Santillana
INTRODUCTION AND OBJECTIVES: Acute appendicitis is the first cause of surgical emergencies. It is still a difficult diagnosis to make, especially in young persons, the elderly, and in reproductive-age women, in whom a series of inflammatory conditions can have signs and symptoms similar to those of acute appendicitis. Different scoring systems have been created to increase diagnostic accuracy, and they are inexpensive, noninvasive, and easy to use and reproduce. The modified Alvarado score is probably the most widely used and accepted in emergency services worldwide...
February 6, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29423825/non-operative-treatment-of-appendicitis-public-perception-and-decision-making
#11
Emer P O'Connell, Annmarie White, Paul Cromwell, Emma Carroll, Waqar Khan, Ronan Waldron, Iqbal Z Khan, Kevin Barry
BACKGROUND: Appendectomy has for many years been the accepted treatment of appendicitis. In recent years, non-operative management of appendicitis (NOTA) has been reported as an effective treatment option. AIMS: We aimed to assess the perspectives of public hospital attendees regarding the diagnosis and treatment options for appendicitis. METHODS: We conducted a cross-sectional survey of outpatients over a 10-week period (December 2016-March 2017)...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29423422/acute-appendicitis-as-the-initial-clinical-presentation-of-primary-hiv-1-infection
#12
Mariane H Schleimann, Steffen Leth, Astrid R Krarup, Jesper Mortensen, Bente Barstad, Matthias Zaccarin, Paul W Denton, Rajesh Mohey
We report a case of an adolescent who presented at our emergency department with acute abdominal pain. While the initial diagnosis was acute appendicitis, a secondary and coincidental diagnosis of primary HIV-1 infection was made. Concurrent and subsequent clinical and molecular biology findings form the basis of our argument that primary HIV-1 infection was the cause of acute appendicitis in this individual.
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29423152/suppurative-appendicitis-presenting-acute-scrotal-pain-a-rare-condition-may-confuse-surgeons
#13
Shahriar Najafizadeh-Sari, Hamidreza Mehdizadeh, Mohammad Sadegh Bagheri-Baghdasht, Shahram Manoochehry
Scrotal pain presentation has many differential diagnoses such as testicular torsion is surgical emergency. For this reason, it is necessary for surgeons to differentiate between diseases for choosing the best treatment approach. We have reported a rare condition of 19-year-old male case had an atypical scrotal pain presentation of appendicitis. He was admitted to emergency service with 4 days history of pain in abdomen and testis. In physical examination, there is tenderness in right lower quadrant, right inguinal region and scrotum...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29422027/ovas-an-open-source-variant-analysis-suite-with-inheritance-modelling
#14
Monika Mozere, Mehmet Tekman, Jameela Kari, Detlef Bockenhauer, Robert Kleta, Horia Stanescu
BACKGROUND: The advent of modern high-throughput genetics continually broadens the gap between the rising volume of sequencing data, and the tools required to process them. The need to pinpoint a small subset of functionally important variants has now shifted towards identifying the critical differences between normal variants and disease-causing ones. The ever-increasing reliance on cloud-based services for sequence analysis and the non-transparent methods they utilize has prompted the need for more in-situ services that can provide a safer and more accessible environment to process patient data, especially in circumstances where continuous internet usage is limited...
February 8, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29421705/discovery-of-thiazolin-4-one-based-aromatic-sulfamates-as-a-new-class-of-carbonic-anhydrase-isoforms-i-ii-iv-and-ix-inhibitors
#15
Alessio Nocentini, Davide Moi, Gianfranco Balboni, Valentina Onnis, Claudiu T Supuran
Herein we report the synthesis of a new series of aromatic sulfamates investigated for the inhibition of four human (h) isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I, II, IV, and IX. The reported derivatives, obtained by a sulfamoylation reaction of the corresponding phenolic precursors, bear arylthiazolin-4-one moieties as spacers between the benzenesulfamate fragment which binds the zinc ion from the active site, and the tail of the inhibitor. Thiazolin-4-ones are biologically privileged scaffolds, endowed with versatile biological activity, such as an anti-proliferative action...
January 27, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29420399/appendiceal-endometriosis-and-ectopic-pregnancy-occurring-simultaneously
#16
Anat Chemerinski, Daniel Lubin, Sevelle Holder, Divya Shah
BACKGROUND: In the setting of a known ectopic pregnancy, severe abdominal pain with clinical concern for rupture is an indication for emergency surgery. In rare cases, appendiceal pathology may occur simultaneously. CASE: A woman with a known ectopic pregnancy presented to the emergency department with a clinical picture consistent with its rupture. At the time of surgery, an appendectomy also was performed owing to concern for concurrent appendicitis; histopathologic examination revealed appendiceal endometriosis...
February 5, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29419956/-evaluation-of-redundancy-of-tests-in-acute-appendicitis
#17
L Rodríguez Caraballo, M E Carazo Palacios, M Couselo Jerez, V Ibáñez Pradas
AIM: Evaluation of the redundancy of abdominal ultrasound tests in the diagnosis of acute appendicitis in a third level hospital. MATERIAL AND METHODS: Retrospective study of patients treated for suspected acute appendicitis in 2011 at our center. The variables of the study were: age, origin of the patient, blood count, number of ultrasounds performed, surgery and final diagnosis based on surgical findings. We defined as redundant ultrasound the request for a new ultrasound in patients with a final diagnosis of appendicitis and previous positive ultrasound...
February 1, 2018: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29419955/-predictive-factors-of-gangrenous-post-appendectomy-intra-abdominal-abscess-a-case-control-study
#18
J Serradilla, A Bueno, C De la Torre, E Domínguez, A Sánchez, B Nava, M Álvarez, M López Santamaría, L Martínez
BACKGROUND: Acute appendicitis is the most frequent surgical urgency in children. Frequently, it can be complicated with an intraabdominal abscess that will require a longer and expensive treatment. Our aim is to know if it is possible to predict this complication before its beginning. MATERIAL AND METHODS: Retrospective case-control study with patients treated between 2011 and 2016, paired according to their own characteristics (age, sex and weight), clinical aspects (symptoms, time of their onset, physical examination) and type of appendicitis (gangrenous)...
February 1, 2018: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29414522/don-t-be-short-sighted-cervical-incompetence-in-a-pregnant-patient-with-acute-appendicitis
#19
Lindsey M Negrete, Lucy B Spalluto
Delay in diagnosis of cervical incompetence can be detrimental to the fetus. Up to 20-25% of miscarriages in the second trimester can be attributed to the incompetent cervix. Given the profound impact of cervical incompetence on obstetric outcomes, careful attention should be given to evaluation of the cervix on MRI studies in pregnant patients. We present a case of incompetent cervix diagnosed incidentally at the time of MRI performed to evaluate for acute appendicitis.
January 31, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29413211/gastrointestinal-traumatic-injuries-gastrointestinal-perforation
#20
REVIEW
Maria A Revell, Marcia A Pugh, Melanie McGhee
The abdomen is a big place even in a small person. Gastrointestinal trauma can result in injury to the stomach, small bowel, colon, or rectum. Traumatic causes include blunt or penetrating trauma, such as gunshot wounds, stabbings, motor vehicle collisions, and crush injuries. Nontraumatic causes include appendicitis, Crohn disease, cancer, diverticulitis, ulcerative colitis, blockage of the bowel, and chemotherapy. The mechanism of injury will affect both the nature and severity of any resulting injuries. Treatment must address the critical and emergent nature of these injuries as well as issues that affect all trauma situations, which include management of hemodynamic instability...
March 2018: Critical Care Nursing Clinics of North America
keyword
keyword
45958
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"