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https://www.readbyqxmd.com/read/29033762/typhoid-fever-and-acute-appendicitis-a-rare-association-not-yet-fully-formed
#1
Daniel J Sartori, Katherine Sun, Mary Ann Hopkins, Mark F Sloane
Infections caused by foodborne enteric pathogens including typhoidal and non-typhoidal Salmonella species can mimic symptoms of acute appendicitis. The association between such bacterial pathogens and pathology-proven acute appendicitis has been described, but this link is poorly understood. Here we describe a case of a young man with typhoid fever presenting with histology-proven acute appendicitis requiring urgent appendectomy, and provide a brief review of relevant literature to prompt more widespread recognition of this rare cause of a common surgical emergency...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29032983/early-versus-late-surgical-management-of-complicated-appendicitis-in-children-a-statewide-database-analysis-with-one-year-follow-up
#2
Saurabh Saluja, Tianyi Sun, Jialin Mao, Shaun A Steigman, P Stephen Oh, Heather L Yeo, Art Sedrakian, Demetri J Merianos
BACKGROUND: Complicated appendicitis is common in children, yet the timing of surgical management remains controversial. Some support initial antibiotics with delayed operation whereas others support immediate operation. While a few randomized trials have evaluated this question, they have been small, single-center trials with limited follow-up. We present a database analysis of outcomes in early versus late surgical management of complicated appendicitis with one-year follow-up. METHODS: We conducted a retrospective review of children with complicated appendicitis presenting between 2000 and 2013, utilizing a New York State database...
October 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29032691/conjugated-hyperbilirubinemia-after-surgery-a-diagnosis-of-dubin-johnson-syndrome-confirmed-by-genetic-testing
#3
Maria Luisa Baranguán Castro, Ruth García Romero, María Dolores Miramar Gallart
Dubin-Johnson syndrome is a rare benign inherited disorder, caused by mutations in ABCC2 gen, and it is characterized by predominantly conjugated hyperbilirubinemia that can be increased by intercurrent infectious illnesses or surgical procedures. We report the case of a 10 year-old patient who showed, after a surgical procedure for peritonitis due to appendicitis, jaundice and predominantly conjugated hyperbilirubinemia, and he was diagnosed with Dubin-Johnson syndrome by genetic testing.
October 16, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29031653/operative-versus-non-operative-management-in-the-care-of-patients-with-complicated-appendicitis
#4
Thomas S Helling, Douglas F Soltys, Samantha Seals
No abstract text is available yet for this article.
October 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29029533/the-immune-impact-of-mimic-endoscopic-retrograde-appendicitis-therapy-and-appendectomy-on-rabbits-of-acute-appendicitis
#5
Suqin Liu, Fenghua Pei, Xinhong Wang, Deliang Li, Lixia Zhao, Yanyan Song, Zhendong Chen, Bingrong Liu
This study was conducted to evaluate the immune impact of mimic endoscopic retrograde appendicitis therapy and appendectomy on rabbits of acute suppurative appendicitis and to determine whether TLR4/MYD88/NF-κB signaling pathway was activated in this process. 48 rabbits were assigned into 4 groups: group I, the mimic endoscopic retrograde appendicitis therapy group; group II, the appendectomy group; group III, the model group; and group IV, the blank group. White blood cells decreased, while levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, interleukin-4, and interleukin-10 increased on the 2(nd) day in group I and II...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027898/surgery-versus-antibiotics-for-uncomplicated-appendicitis-which-would-a-medical-student-want
#6
Alison R Althans, Pierre Tamer, Justin T Brady, Emily Steinhagen, Vanessa P Ho
BACKGROUND: Recent data suggest that treatment of acute, uncomplicated appendicitis (AUA) with antibiotics is as effective as surgery. A 2015 study indicated that more than 50% of patients would choose antibiotic therapy. Medical students represent a unique population of potential patients with greater medical knowledge than the general public and possibly less bias than practicing physicians. Therefore, we aimed to evaluate what the MEDICAL STUDENT'S treatment choice for AUA would be and what factors influence these decisions...
October 13, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29026959/effects-of-timing-of-appendectomy-on-the-risks-of-perforation-and-postoperative-complications-of-acute-appendicitis
#7
Jong Wan Kim, Dong Woo Shin, Doo Jin Kim, Jeong Yeon Kim, Sung Gil Park, Jun Ho Park
BACKGROUND: It is generally believed that appendectomy should be performed immediately to prevent perforation and complications. Therefore, our objectives were to investigate the effect of timing of appendectomy on the incidence of perforation and complications. METHODS: We retrospectively reviewed the medical records of patients who underwent laparoscopic appendectomy between January 2014 and June 2015. The time from symptom onset to appendectomy was categorized into three periods: time from symptom onset to hospital admission (symptomatic time), time from admission to appendectomy (hospitalization time), and time from symptom onset to appendectomy [symptomatic period + hospitalization period (overall time)]...
October 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29026644/wet-spinning-fabrication-of-shear-patterned-alginate-hydrogel-microfibers-and-the-guidance-of-cell-alignment
#8
You Yang, Jing Sun, Xiaolu Liu, Zhenzhen Guo, Yunhu He, Dan Wei, Meiling Zhong, Likun Guo, Hongsong Fan, Xingdong Zhang
Native tissue is naturally comprised of highly-ordered cell-matrix assemblies in a multi-hierarchical way, and the nano/submicron alignment of fibrous matrix is found to be significant in supporting cellular functionalization. In this study, a self-designed wet-spinning device appended with a rotary receiving pool was used to continuously produce shear-patterned hydrogel microfibers with aligned submicron topography. The process that the flow-induced shear force reshapes the surface of hydrogel fiber into aligned submicron topography was systematically analysed...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29025988/advanced-methods-for-radiolabelling-nanomedicines-for-multi-modality-nuclear-mr-imaging
#9
Jennifer R Lamb, Jason P Holland
The advent of hybrid cameras that combine magnetic resonance imaging with either single-photon emission computed tomography (SPECT/MRI) or positron-emission tomography (PET/MRI) has stimulated growing interest in developing multi-modality imaging probes. Countless options are available for fusing magnetically active species with positron- or gamma-ray emitting radionuclides. The initial problem is one of choice: which chemical systems are a suitable basis for developing hybrid imaging agents? Any attempt to answer this question must also address how the physical, chemical, and biological properties of a unified imaging agent can be tailored to ensure that optimum specificity and contrast is achieved simultaneously for both imaging modalities...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29024841/complicated-acute-appendicitis-presenting-as-an-abscess-in-the-abdominal-wall-in-an-elderly-patient-a-case-report
#10
Ibrahim Massuqueto Andrade Gomes de Souza, Diego Antonio De Almeida Nunes, Carolina Morandim Granito Massuqueto, Marcos Alberto de Mendonça Veiga, Horacio Tamada
INTRODUCTION: Appendicitis is a common cause of acute abdomen; however, the classic clinical signs are not often present, and it has unusual presentations. Thus, its diagnosis can be challenging. PRESENTATION OF CASE: We describe the case of an elderly man who presented with right abdominal wall abscess with spontaneous drainage in the emergency department. Since we suspected a subjacent abdominal pathology, we performed surgery, and intraoperatively, we observed that the Appendix tip had invaded the abdominal wall...
October 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29024242/lanthanide-based-t2ex-and-cest-complexes-provide-new-insights-into-the-design-of-ph-sensitive-mri-agents
#11
Lei Zhang, Andre F Martins, Piyu Zhao, Yunkou Wu, Gyula Tircso, Dean Sherry
A series of Eu3+ and Dy3+ DOTA-tetraamide complexes with four appended primary amine groups were prepared and their CEST and T1/T2 relaxation properties measured as a function of pH. The CEST signals in the Eu3+ complexes show a surprisingly strong CEST signal after the pH was reduced from 8 to 5. The opposite trend was observed for the Dy3+ complexes where the r2ex of bulk water protons increased dramatically from ~1.5 mM-1s-1 to ~13 mM-1s-1, while r1 remained unchanged. A fit of the CEST data (Eu3+ complexes) to Bloch theory and the T2 data (Dy3+ complexes) to Swift-Connick theory provided the proton exchange rates as a function of pH...
October 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29023495/the-hnrnp-like-nab3-termination-factor-can-employ-heterologous-prion-like-domains-in-place-of-its-own-essential-low-complexity-domain
#12
Travis J Loya, Thomas W O'Rourke, Daniel Reines
Many RNA-binding proteins possess domains with a biased amino acid content. A common property of these low complexity domains (LCDs) is that they assemble into an ordered amyloid form, juxtaposing RNA recognition motifs in a subcellular compartment in which RNA metabolism is focused. Yeast Nab3 is one such protein that contains RNA-binding domains and a low complexity, glutamine/proline-rich, prion-like domain that can self-assemble. Nab3 also contains a region of structural homology to human hnRNP-C that resembles a leucine zipper which can oligomerize...
2017: PloS One
https://www.readbyqxmd.com/read/29020470/diagnostic-value-of-plasma-pentraxin-3-in-acute-appendicitis
#13
Ali Aygun, Burak Katipoglu, Melih Ïmamoglu, Selim Demir, Metin Yadigaroglu, Ozgur Tatli, Selim Yurtsever, Arif Usta, Ahmet Mentese, Suha Turkmen
PURPOSE: To measure serum PTX3 levels in patients admitted with right lower quadrant pain to emergency department and to investigate whether this parameter will be helpful for the diagnosis of acute appendicitis. MATERIALS AND METHODS: This study was conducted with a group of 89 patients over 17 years of age who were admitted with the complaint of right lower quadrant pain to ED and had a preliminary diagnosis of acute appendicitis clinically and the control group of 31 healthy volunteers in a tertiary university hospital for 3 months...
October 11, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29019885/two-incision-laparoscopic-appendectomy-for-a-severe-hemophilia-a-child-patient-with-coagulation-factor-vii-deficiency-case-report-and-review-of-literature
#14
Jin Peng He, Jie Xiong Feng
RATIONALE: The main complication of patients with severe hemophilia is recurrent bleeding events that usually affected musculoskeletal contractures. And replacement therapy methods were continuously improved to minimize adverse impacts brought by those complications. However, only several cases reported about the appendectomy for hemophilia A. We report a case of acute appendicitis treated by two-incision laparoscopy in a boy with hemophilia A and coagulation factor VII deficiency for the first time...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29017194/non-operative-management-for-uncomplicated-appendicitis-an-option-to-consider
#15
Olivier Abbo, Carmen Trabanino, Kalitha Pinnagoda, Amir Ait Kaci, Luana Carfagna, Sofia Mouttalib, Sophie Combelles, Julie Vial, Philippe Galinier
No abstract text is available yet for this article.
October 10, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29016242/early-predictors-of-abscess-development-after-perforated-pediatric-appendicitis
#16
Catherine M Dickinson, Nathan A Coppersmith, Francois I Luks
BACKGROUND: Approximately one-third of children with appendicitis present with advanced disease or perforation. Whereas this increases the risk for post-operative complications and re-admission, it is not yet possible to predict early on who will develop an abdominal abscess. We sought to identify specific risk factors for this complication, in an attempt to streamline post-operative care. PATIENTS AND METHODS: We reviewed the records of all cases of perforated appendicitis over a 12-month period at a tertiary children's hospital...
October 10, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29016218/impact-of-resident-performed-laparoscopic-appendectomy-on-patient-outcomes-and-safety
#17
Wonkyeong Lee, Sun Jin Park, Min-Su Park, Kil Yeon Lee
BACKGROUND: Laparoscopic appendectomy is a training model for surgical residents to begin their surgical experience. However, there is concern about worse outcomes of surgery performed by inexperienced residents. We investigated surgical outcomes and patient safety in laparoscopic appendectomy performed by residents. MATERIALS AND METHODS: This is a retrospective cohort study of all consecutive patients operated on for acute appendicitis in a single tertiary hospital...
October 10, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28991466/enantioselective-recognition-of-ammonium-carbamates-in-a-chiral-metal-organic-framework
#18
Jeffrey D Martell, Leo B Porter-Zasada, Alexander C Forse, Rebecca L Siegelman, Miguel I Gonzalez, Julia Oktawiec, Tomce Runcevski, Jiawei Xu, Monika Srebro-Hooper, Phillip J Milner, Kristen A Colwell, Jochen Autschbach, Jeffrey A Reimer, Jeffrey R Long
Chiral metal-organic frameworks have attracted interest for enantioselective separations and catalysis because of their high crystallinity and pores with tunable shapes, sizes, and chemical environments. Chiral frameworks of the type M2(dobpdc) (M = Mg, Mn, Fe, Co, Ni, Zn; dobpdc4- = 4,4'-dioxidobiphenyl-3,3'-dicarboxylate) seem particularly promising for potential applications, owing to their excellent stability, high internal surface areas, and the strongly polarizing open metal coordination sites within the channels, but to date these materials have only been isolated in racemic form...
October 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28990753/novel-electrophilic-scaffold-for-imaging-of-essential-penicillin-binding-proteins-in-streptococcus-pneumoniae
#19
Shabnam Sharifzadeh, Michael J Boersma, Ozden Kocaoglu, Alireza Shokri, Clayton L Brown, Joshua D Shirley, Malcolm E Winkler, Erin E Carlson
Peptidoglycan (PG) is a mesh-like heteropolymer made up of glycan chains crosslinked by short peptides and is the major scaffold of eubacterial cell walls, determining cell shape, size and chaining. This structure, which is required for growth and survival, is located outside of the cytoplasmic membrane of bacterial cells making it highly accessible to antibiotics. Penicillin-binding proteins (PBPs) are essential for construction of PG and perform transglycosylase activities to generate the glycan strands and transpeptidation to crosslink the appended peptides...
October 9, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28988360/correction-to-challenges-in-minor-tbi-and-indications-for-head-ct-in-pediatric-tbi-an-update
#20
Navneet Singh, Ash Singhal
The published version of this article unfortunately contained an error.An error in the Abstract was introduced during corrections stage when a "Conclusion" section appended is from a different article and was not provided from authors.
October 7, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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