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https://www.readbyqxmd.com/read/29146462/individual-serum-bile-acid-profiling-in-rats-aids-in-human-risk-assessment-of-drug-induced-liver-injury-due-to-bsep-inhibition
#1
Steven Cepa, David Potter, Lisa Wong, Leah Schutt, Jacqueline Tarrant, Jodie Pang, Xiaolin Zhang, Roxanne Andaya, Laurent Salphati, Yingqing Ran, Le An, Ryan Morgan, Jonathan Maher
Drug-induced liver injury (DILI) has been the most frequent cause of post-marketing drug withdrawals in the last 50years. The multifactorial nature of events that precede severe liver injury in human patients is difficult to model in rodents due to a variety of confounding or contributing factors that include disease state, concurrent medications, and translational species differences. In retrospective analyses, a consistent risk factor for DILI has been the inhibition of the Bile Salt Export Pump (BSEP). One compound known for potent BSEP inhibition and severe DILI is troglitazone...
November 13, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29145996/-comparative-profile-of-the-use-of-filter-needles-in-quebec-and-france-in-healthcare-facility
#2
L Painchart, P Odou, J-F Bussières
OBJECTIVES: The manipulation of drugs from glass ampules can generate particles when the ampule is broken. Several authors recommend the use of filter needle to withdraw the drug content. The main objective is to establish an inventory of the use of filter needles and the perception of pharmacists in Quebec and in France. METHODS: This is a cross-sectional descriptive study. A questionnaire was sent to all health facilities in Quebec (n=30) and a selection of hospitals in France (n=100)...
November 13, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29142795/comorbid-post-traumatic-stress-disorder-and-opioid-dependence
#3
Rikinkumar S Patel, Ahmed Elmaadawi, Suhayl Nasr, John Haskin
Post-traumatic stress disorder (PTSD) is predominant amongst individuals addicted to opioids and obscures the course of illness and the treatment outcome. We report the case of a patient with major depressive disorder and opioid dependence, who experienced post-traumatic stress disorder symptoms during a recent visit to the inpatient unit. The similarity of symptoms between post-traumatic stress disorder and opioid dependence is so high that, sometimes, it is a challenge to differentiate between these conditions...
September 3, 2017: Curēus
https://www.readbyqxmd.com/read/29141948/a-phase-i-study-of-romidepsin-and-pralatrexate-reveals-marked-activity-in-relapsed-and-refractory-t-cell-lymphoma
#4
Jennifer E Amengual, Renee Lichtenstein, Jennifer Lue, Ahmed Sawas, Changchun Deng, Emily Lichtenstein, Karen Khan, Laine Atkins, Aishling Rada, Hye A Kim, Codruta Chiuzan, Matko Kalac, Enrica Marchi, Lorenzo Falchi, Mark A Francescone, Lawrence Schwartz, Serge Cremers, Owen A O'Connor
The peripheral T-cell lymphomas (PTCL) are a group of rare malignancies characterized by chemotherapy insensitivity and poor prognosis. Romidepsin and pralatrexate were approved by the U.S. FDA for patients with relapsed/refractory PTCL, exhibiting response rates of 25% and 29% respectively. Based on synergy of the combination in preclinical models of PTCL, we initiated a phase I study of pralatrexate plus romidepsin in patients with relapsed/refractory lymphoma (ClinicalTrials.gov (NCT01947140)). This was a single institution dose-escalation phase I study of pralatrexate plus romidepsin designed to determine the dose limiting toxicities (DLT), maximum tolerated dose (MTD), pharmacokinetic profile and response rates...
November 15, 2017: Blood
https://www.readbyqxmd.com/read/29125226/loperamide-cardiotoxicity-a-brief-review
#5
REVIEW
Tamer Akel, Soad Bekheit
Loperamide is a popular antidiarrheal medication that has been used for many years. It is currently gaining more attention among healthcare professionals due to its increasing potential for side effects. At present, it is considered safe enough to be sold over the counter. In contrast with other opioid agonists, loperamide is a peripherally acting μ-receptor agonist exerting its effects mainly on the myenteric plexus of the gastrointestinal longitudinal muscle layer. It decreases peristalsis and fluid secretion resulting in longer gastrointestinal transit time...
November 10, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29123362/lessons-from-practice-designing-tools-to-facilitate-individualized-support-for-quitting-smoking
#6
Arpita Bhattacharya, Roger Vilardaga, Julie A Kientz, Sean A Munson
Many health care providers, with a variety of trainings, counsel clients on quitting smoking on a day-to-day basis. In their clinical practice, they draw from and adapt guidelines and research-based strategies to fit individual client situations and challenges. Designers of technologies to support quitting smoking can learn from these real world practices to create tools that better adapt to individual differences. We present findings from interviews with 28 providers with diverse experiences in smoking cessation counselling...
2017: ACM Transactions on Computer-human Interaction: a Publication of the Association for Computing Machinery
https://www.readbyqxmd.com/read/29119806/ethical-dilemmas-associated-with-clinicians-decisions-about-treatment-in-critically-ill-infants-born-in-c%C3%A3-rdoba-argentina
#7
Agustín Alfredo Silberberg, Juan Eduardo Gallo
The objective of this article is to examine end of life decisions made by neonatologists of Córdoba, Argentina. An anonymous questionnaire was designed to investigate neonatologists' decisions on when to initiate or withdraw treatment in critical neonates. All neonatologists who take care of critically ill neonates in Córdoba participated in the survey. More than 75% of them would initiate treatment in preterm infants with uncertain prognosis based on the viability of the newborn. Because it is common to find that critically ill neonates lack sufficient diagnostic information at birth, this attitude seems to manifest a certain therapeutic activism...
March 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29113937/characterization-of-gastrointestinal-adverse-effects-reporting-in-clinical-studies-of-corticosteroid-therapy
#8
Tone Westergren, Sigrid Narum, Marianne Klemp
OBJECTIVE: To examine whether 159 studies included in a previous meta-analysis reported on gastrointestinal bleeding or perforation in accordance with the the CONSORT extension for reporting harms outcomes (CONSORT Harms recommendations checklist), whether differences were associated with funding source, journal or publication year, and whether the CONSORT Harms checklist is a suitable tool for evaluation of adverse effects reporting. STUDY DESIGN AND SETTING: Articles were assessed for fulfilment of the CONSORT Harms recommendations, funding source, publication type and year...
November 4, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29105267/caution-needed-in-introduction-of-provisional-approvals-for-medicines
#9
Jessica Pace, Narcyz Ghinea, Ian Kerridge, Wendy Lipworth
The Australian government recently released its response to the Review of Medicines and Medical Devices Regulation, accepting most recommendations. One recommendation involves the introduction of provisional approvals for perceived life-saving and innovative new treatments, allowing these to be approved on the basis of more limited data on the condition that further safety and efficacy data (including real-world evidence) are collected to determine whether full approval should be granted. However, experience with similar schemes overseas raises significant questions about the safety and efficacy of products made available through these pathways...
November 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29103663/takotsubo-cardiomyopathy-precipitated-by-opiate-withdrawal
#10
Peter C Olson, Vratika Agarwal, James C Lafferty, Soad Bekheit
INTRODUCTION: Takotsubo Cardiomyopathy is a transient non-ischemic cardiomyopathy usually characterized by apical ballooning of the left ventricle, with electrocardiographic changes and enzyme release, without evidence of obstructive coronary artery disease. Typically seen in stress induced situations, in post-menopausal females, this condition may have a predilection for patients with dependency disorders. CASE: The following is a case in which Takotsubo Cardiomyopathy was induced by withdrawal from opiate medications...
November 2, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/29098669/similarities-and-differences-in-neuroimaging
#11
Yan-Kun Sun, Yan Sun, Xiao Lin, Lin Lu, Jie Shi
Addiction is a chronically relapsing disease characterized by drug intoxication, craving, bingeing, and withdrawal with loss of control. An increasing number of studies have indicated that non-substance addiction, like internet addiction and pathological gambling, share clinical, phenomenological, and biological features with substance addiction. With the development of imaging technology in the past three decades, neuroimaging studies have provided information on the neurobiological effects, and revealed neurochemical and functional changes in the brains of both drug-addicted and non-substance addicted subjects...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29095320/transient-sick-sinus-syndrome-with-complete-atrioventricular-block-associated-with-ergonovine-intake-a-case-report
#12
Hui-Ting Wang, Wen-Hao Liu, Yung-Lung Chen
RATIONALE: More mature or older women are more likely to undergo in vitro fertilization and embryo implant. These women have a greater chance of receiving ergonovine therapy because of a suspected abortion. We present this case report to call attention to a latent lethal adverse effect in everyday obstetric practice using ergonovine. It requires more attention and close monitoring PATIENT CONCERNS:: We presented the case of a 38-year-old female patient with general weakness and mild chest tightness after ergonovine use...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29095288/severe-enteropathy-with-villous-atrophy-in-prolonged-mefenamic-acid-users-a-currently-under-recognized-in-previously-well-recognized-complication-case-report-and-review-of-literature
#13
REVIEW
Uayporn Kaosombatwattana, Julajak Limsrivilai, Ananya Pongpaibul, Monthira Maneerattanaporn, Phunchai Charatcharoenwitthaya
RATIONALE: Mefenamic acid-induced enteropathy may be an under-recognized condition because few reported cases and no review of literature to comprehensively describe all reported cases exist. From inception until February 2017, a systematic literature search identified twenty original reports of cases of mefenamic acid-induced enteropathy. Additional five cases were identified at our hospital. All cases were included in the analyses. PATIENT CONCERNS: Most patients had been regularly taking therapeutic dosages of mefenamic acid for at least three months before symptoms developed...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29095112/assessment-of-elimination-profile-of-albendazole-residues-in-fish
#14
Zenaís Busatto, Welliton Gonçalves de França, José Eurico Possebon Cyrino, Jonas Augusto Rizzato Paschoal
Few drugs are specifically regulated for aquaculture. Thus this study considered albendazole (ABZ) as a potential drug for use in fish, which, however, is not yet regulated for this application. ABZ is a broad-spectrum anthelmintic approved for farmed ruminants and recently considered for treatment of fish parasites. It is the subject of careful monitoring because of potential residues in animal products. This study evaluated the depletion of ABZ and its main known metabolites: albendazole sulfoxide - ABZSO, albendazole sulfone - ABZSO2 and albendazole amino sulfone - ABZ-2-NH2SO2, in the fillets of the Neotropical Characin pacu, Piaractus mesopotamicus, which were fed diets containing 10 mg ABZ kg(-1) body weight in a single dose...
November 14, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29090362/case-report-domperidone-use-as-a-galactagogue-resulting-in-withdrawal-symptoms-upon-discontinuation
#15
Marley Doyle, Mila Grossman
We present a case of domperidone withdrawal in a woman using the medication as a galactagogue. Our primary goal is to increase the literature available to providers who work with women who are breastfeeding. We evaluated a woman presenting to our reproductive psychiatry clinic for consultation regarding anxiety and agitation in the context of domperidone discontinuation. We evaluated the available literature regarding domperidone as a galactagogue, as well as the literature regarding adverse effects. The patient presented with withdrawal symptoms after gradual taper and discontinuation of domperidone...
October 31, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29089238/-clinical-and-pathological-definition-of-temporal-medium-epilepsy-subtypes-with-hypocampic-sclerosis
#16
Gonzalo Olivares-Granados, Rosa María Ríos-Pelegrina, Jesús Ruiz-Giménez, Alberto Galdón-Castillo, Teresa Escobar-Delgado, Raimundo García Del Moral
BACKGROUND AND OBJECTIVE: Mesial temporal lobe epilepsy with hippocampal sclerosis is the most common cause of refractory epilepsy, and the most common indication for surgery. Although effective, surgery fails in up to 40% of patients. The objective of our study was to establish a correlation between the different histological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis and the prognosis, seizures control, side effects and anticonvulsivant drug withdrawal in patients with refractory epilepsy...
October 28, 2017: Neurocirugía
https://www.readbyqxmd.com/read/29084313/safety-and-efficacy-of-focused-ultrasound-thalamotomy-for-patients-with-medication-refractory-tremor-dominant-parkinson-disease-a-randomized-clinical-trial
#17
Aaron E Bond, Binit B Shah, Diane S Huss, Robert F Dallapiazza, Amy Warren, Madaline B Harrison, Scott A Sperling, Xin-Qun Wang, Ryder Gwinn, Jennie Witt, Susie Ro, W Jeffrey Elias
Importance: Clinical trials have confirmed the efficacy of focused ultrasound (FUS) thalamotomy in essential tremor, but its effectiveness and safety for managing tremor-dominant Parkinson disease (TDPD) is unknown. Objective: To assess safety and efficacy at 12-month follow-up, accounting for placebo response, of unilateral FUS thalamotomy for patients with TDPD. Design, Setting, and Participants: Of the 326 patients identified from an in-house database, 53 patients consented to be screened...
October 30, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29084292/efficacy-and-safety-of-dapsone-as-second-line-therapy-for-adult-immune-thrombocytopenia-a-retrospective-study-of-42-patients
#18
Clémentine Estève, Maxime Samson, Alexandre Guilhem, Barbara Nicolas, Vanessa Leguy-Seguin, Sabine Berthier, Bernard Bonnotte, Sylvain Audia
Dapsone is recommended as a second line therapy in immune thrombocytopenia (ITP), but is underused because of its potential side effects. The medical charts of 42 ITP patients treated with dapsone (100 mg/day) were retrospectively reviewed in order to assess its efficacy and safety in daily clinical practice. The overall response rate was 54.8% (n = 22, with a complete response in 38.1%) with a median time to response of 29 days (24-41 days). Patients with complete response had shorter disease duration whereas no difference was observed between responders and non-responders regarding age, sex or previous treatments received...
2017: PloS One
https://www.readbyqxmd.com/read/29080523/fatal-poisonings-involving-propoxyphene-before-and-after-voluntary-withdrawal-from-the-united-states-market-an-analysis-from-the-state-of-florida
#19
Chris Delcher, Guanming Chen, Yanning Wang, Svetla Slavova, Bruce A Goldberger
The synthetic opioid propoxyphene was a schedule IV controlled substance with multiple reported health risks before the US Food and Drug Administration issued a request for voluntary market withdrawal in November 2010. The purpose of this study is to investigate the characteristics and occurrences of propoxyphene-related deaths in Florida before and after voluntary market removal. Decedent-level toxicology data from Florida's Medical Examiners Commission was used to compare the temporal, polysubstance use, sociodemographic, and geographic profiles associated with propoxyphene-involved deaths for a pre-withdrawal (November 2008-November 2010) and post-withdrawal (December 2010-December 2012) period...
October 14, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29078100/prenatal-substance-exposure-diagnosed-at-birth-and-infant-involvement-with-child-protective-services
#20
John J Prindle, Ivy Hammond, Emily Putnam-Hornstein
Infants have the highest rates of maltreatment reporting and entries to foster care. Prenatal substance exposure is thought to contribute to early involvement with child protective services (CPS), yet there have been limited data with which to examine this relationship or variations by substance type. Using linked birth, hospital discharge, and CPS records from California, we estimated the population prevalence of medically diagnosed substance exposure and neonatal withdrawal disorders at birth. We then explored the corresponding rates of CPS involvement during the first year of life by substance type after adjusting for sociodemographic and health factors...
October 24, 2017: Child Abuse & Neglect
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