Partha Saha, Mangala Hegde, Kanak Chakraborty, Achinta Singha, Nobendu Mukerjee, Deepshikha Ghosh, Ajaikumar B Kunnumakkara, Mohd Shahnawaz Khan, Md Irshad Ahmad, Arabinda Ghosh, Ajoy Kumer, Samir Kumar Sil
The anti-apoptotic proteins, Bcl-2 and Survivin, are consistently overexpressed in numerous human malignancies, notably in colorectal cancer. 2,4-Di-tert-butylphenol (2,4-DTBP) is a naturally occurring phenolic compound known for its diverse biological activities, including anti-cancer properties. The mechanism behind 2,4-DTBP-induced inhibition of cell proliferation and apoptosis in human colorectal cancer cells, specifically regarding Bcl-2 and Survivin, remains to be elucidated. In this study, we employed both in silico and in vitro methodologies to underpin this interaction at the molecular level...
April 2024: Journal of Cellular and Molecular Medicine