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https://www.readbyqxmd.com/read/29156629/reconstruction-of-craniomaxillofacial-bone-defects-using-tissue-engineering-strategies-with-injectable-and-non-injectable-scaffolds
#1
REVIEW
Bipin Gaihre, Suren Uswatta, Ambalangodage C Jayasuriya
Engineering craniofacial bone tissues is challenging due to their complex structures. Current standard autografts and allografts have many drawbacks for craniofacial bone tissue reconstruction; including donor site morbidity and the ability to reinstate the aesthetic characteristics of the host tissue. To overcome these problems; tissue engineering and regenerative medicine strategies have been developed as a potential way to reconstruct damaged bone tissue. Different types of new biomaterials; including natural polymers; synthetic polymers and bioceramics; have emerged to treat these damaged craniofacial bone tissues in the form of injectable and non-injectable scaffolds; which are examined in this review...
November 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29156586/in-depth-glyco-peptidomics-approach-reveals-unexpected-diversity-of-glycosylated-peptides-and-atypical-post-translational-modifications-in-dendroaspis-angusticeps-snake-venom
#2
Michel Degueldre, Julien Echterbille, Nicolas Smargiasso, Christian Damblon, Charlotte Gouin, Gilles Mourier, Nicolas Gilles, Edwin De Pauw, Loïc Quinton
Animal venoms represent a valuable source of bioactive peptides that can be derived into useful pharmacological tools, or even innovative drugs. In this way, the venom of Dendroaspis angusticeps (DA), the Eastern Green Mamba, has been intensively studied during recent years. It mainly contains hundreds of large toxins from 6 to 9 kDa, each displaying several disulfide bridges. These toxins are the main target of venom-based studies due to their valuable activities obtained by selectively targeting membrane receptors, such as ion channels or G-protein coupled receptors...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156401/nine-reasons-why-ecstasy-is-not-quite-what-it-used-to-be
#3
Jane Mounteney, Paul Griffiths, Alessandra Bo, Andrew Cunningham, Joao Matias, Alessandro Pirona
This paper explores the recent resurgence in use of ecstasy/MDMA in Europe and highlights keys areas of continuity and divergence between the ecstasy market of the 1990s and the current MDMA market. Based on a scoping study involving a targeted multi-source data collection exercise on MDMA, it highlights nine areas that have undergone some level of change, linked with both supply and demand for the drug. Factors discussed include: innovation in production techniques; changes in precursor chemical availability; the role of online markets; competition with other stimulants and new psychoactive substances; the increased availability of high-strength MDMA; and the shift from subcultural towards more mainstream use of the drug...
November 17, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29156391/optimal-allocation-of-physical-water-resources-integrated-with-virtual-water-trade-in-water-scarce-regions-a-case-study-for-beijing-china
#4
Quanliang Ye, Yi Li, La Zhuo, Wenlong Zhang, Wei Xiong, Chao Wang, Peifang Wang
This study provides an innovative application of virtual water trade in the traditional allocation of physical water resources in water scarce regions. A multi-objective optimization model was developed to optimize the allocation of physical water and virtual water resources to different water users in Beijing, China, considering the trade-offs between economic benefit and environmental impacts of water consumption. Surface water, groundwater, transferred water and reclaimed water constituted the physical resource of water supply side, while virtual water flow associated with the trade of five major crops (barley, corn, rice, soy and wheat) and three livestock products (beef, pork and poultry) in agricultural sector (calculated by the trade quantities of products and their virtual water contents)...
November 14, 2017: Water Research
https://www.readbyqxmd.com/read/29156386/an-innovative-method-for-the-solidification-stabilization-of-pahs-contaminated-soil-using-sulfonated-oil
#5
Fujun Ma, Bin Wu, Qian Zhang, Deshan Cui, Qingbing Liu, Changsheng Peng, Fasheng Li, Qingbao Gu
Stabilization/solidification (S/S) has been successfully employed in many superfund sites contaminated with organic materials. However, this method's long-term effectiveness has not been fully evaluated and the increase in soil volume following treatment is unfavorable to follow-up disposal. The present study developed a novel method for the S/S of PAHs-contaminated soil with the facilitation of sulfonated oil (SO). Adding SO significantly improved the unconfined compressive strength (UCS) values of Portland cement and activated carbon (PC-AC) treated soil samples, and the UCS values of the soil sample treated with 0...
November 7, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29156369/mixed-bacterial-culture-mediated-direct-conversion-of-bio-glycerol-to-diols
#6
Roopa Parate, Rasika Mane, Mahesh Dharne, Chandrashekhar Rode
Direct and economic transformation of biodiesel derived crude glycerol is gaining more significance. During screening of bacterial cultures Klebsiella pneumoniae and Enterobacter aerogenes were able to convert crude bio-glycerol to 2,3-butanediol (2,3-BDO) and 1,3-propanediol (1,3-PDO), as major compounds, ethanol and acetoin as minor compounds, with a conversion of 69% and 79% respectively. Process optimization could achieve maximum conversion at pH 7.0, 37 °C, 30-40 g/L glycerol and 1.5 g of inoculum until 120 h...
November 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29156353/in-situ-formation-of-textured-tin-coatings-on-biomedical-titanium-alloy-by-laser-irradiation
#7
Xueyang Zhao, Peng Zhang, Xiaojian Wang, Yun Chen, Hui Liu, Lianxi Chen, Yinying Sheng, Wei Li
The Ti-35Nb-7Zr-5Ta (TNZT) alloy has received much research attention among the biomedical titanium alloys for its low Young's modulus and outstanding biocompatibility. This paper provided an innovative technique for improving the wear and corrosion resistance of the TNZT alloy, by developing in-situ formed TiN coatings on the surface of the TNZT alloy through laser irradiation. The new technique combines the advantages of laser surface texturing and laser gas alloying. The experimental results showed that the phase compositions of the textured TNZT samples were β-Ti, martensitic α'' phase and TiN after laser texturing in N2...
November 14, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29156348/development-of-photoprotective-antiphototoxic-and-antiphotogenotoxic-formulations-of-ocular-drugs-with-fluoroquinolones
#8
Anna Zgadzaj, Joanna Kornacka, Anita Jastrzębska, Andrzej Parzonko, Sylwester Sommer, Grzegorz Nałęcz-Jawecki
The development of innovative solutions in photosafety of photolabile pharmaceutical products may help to reduce the adverse effects of these products, caused by light exposure. Providing new data in this area of study is particularly important in case of drugs applied topically on sensitive organs such as eyes. The main goal of this research is to investigate whether two potential excipients, namely: p-coumaric acid and benzophenone-4, affect the photodegradation, phototoxicity and photogenotoxicity of water solutions of four fluoroquinolones: ciprofloxacin, lomefloxacin, fleroxacin and clinafloxacin...
November 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29156177/proceedings-of-the-american-association-of-oral-and-maxillofacial-surgeon-s-2017-clinical-and-scientific-innovations-in-oral-and-maxillofacial-surgery-csioms
#9
Joseph E Cillo, Tara Aghaloo, David Basi, Gary F Bouloux, Joshua A Campbell, Joli Chou, Thomas Dodson, Sean P Edwards, Deepak Kademani, Zachary Peacock
The sixth biennial Clinical and Scientific Innovations in Oral and Maxillofacial Surgery, formerly the Research Summit, of the American Association of Oral and Maxillofacial Surgeons and its Committee on Research Planning and Technology Assessment was held in Rosemont, Illinois from April 28 to 30, 2017. The goal of the symposium is to provide a forum for the latest clinical and scientific advances to be brought to the specialty. It also nurtures collaboration and the development of relationships between oral and maxillofacial surgeons and researchers to bridge the gap between clinical and basic science...
October 26, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29156118/strategies-in-assessment-of-leadership-competencies
#10
David M Rosch, Kerry L Priest
This chapter focuses on common pitfalls in assessing leadership competencies, simple strategies to avoid them, and innovative theoretical approaches and strategies in assessment.
December 2017: New Directions for Student Leadership
https://www.readbyqxmd.com/read/29156027/why-has-nhs-england-introduced-an-innovation-and-technology-tariff-to-improve-safer-arterial-systems-in-england
#11
S Thillainathan, M Z Mariyaselvam
No abstract text is available yet for this article.
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29156009/discovering-cancer-vulnerabilities-using-high-throughput-micro-rna-screening
#12
Iva Nikolic, Benjamin Elsworth, Eoin Dodson, Sunny Z Wu, Cathryn M Gould, Pieter Mestdagh, Glenn M Marshall, Lisa G Horvath, Kaylene J Simpson, Alexander Swarbrick
Micro-RNAs (miRNAs) are potent regulators of gene expression and cellular phenotype. Each miRNA has the potential to target hundreds of transcripts within the cell thus controlling fundamental cellular processes such as survival and proliferation. Here, we exploit this important feature of miRNA networks to discover vulnerabilities in cancer phenotype, and map miRNA-target relationships across different cancer types. More specifically, we report the results of a functional genomics screen of 1280 miRNA mimics and inhibitors in eight cancer cell lines, and its presentation in a sophisticated interactive data portal...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155720/m%C3%A3-ller-glia-cell-activation-in-a-laser-induced-retinal-degeneration-and-regeneration-model-in-zebrafish
#13
Federica M Conedera, Petra Arendt, Carolyn Trepp, Markus Tschopp, Volker Enzmann
A fascinating difference between teleost and mammals is the lifelong potential of the teleost retina for retinal neurogenesis and regeneration after severe damage. Investigating the regeneration pathways in zebrafish might bring new insights to develop innovative strategies for the treatment of retinal degenerative diseases in mammals. Herein, we focused on the induction of a focal lesion to the outer retina in adult zebrafish by means of a 532 nm diode laser. A localized injury allows investigating biological processes that take place during retinal degeneration and regeneration directly at the area of damage...
October 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155559/crafting-of-neuroprotective-octapeptide-from-taxol-binding-pocket-of-%C3%AE-tubulin
#14
Prasenjit Mondal, Gaurav Das, Juhee Khan, Krishnangsu Pradhan, Surajit Ghosh
Microtubules play crucial role in maintaining the shape and function of neurons. During progression of Alzheimer's disease (AD), severe destabilization of microtubule occurs, which leads to the permanent disruption of signal transduction process and memory loss. Thus, microtubule stabilization is one of the key requirements for the treatment of AD. Taxol, a microtubule stabilizing anti-cancer drug has been considered as potential anti-AD drug but never tested in AD patients, likely because of its' toxic nature and poor brain exposure...
November 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29155366/applications-of-stimuli-responsive-nanoscale-drug-delivery-systems-in-translational-research
#15
REVIEW
Mengjie Gu, Xin Wang, Tan Boon Toh, Edward Kai-Hua Chow
Nanoscale drug delivery systems or nanocarriers have shown tremendous promise in the target-specific delivery of therapeutics as well as diagnostic agents. Additional properties can be introduced into nanocarriers to enhance the bioavailability and targeting efficiency of the transported drugs at diseased sites. Such nanocarriers are usually incorporated with stimuli-responsive components that can be triggered by specific stimuli (e.g., temperature, pH, or enzymes) and further induced by certain biological responses, such as enzyme hydrolysis and molecular conformational changes, leading to the controlled release of the transported molecules at targeted sites...
November 16, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29155256/role-of-toll-like-receptors-in-inflammatory-bowel-disease
#16
REVIEW
Nastaran Kordjazy, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Mohammad Mojtaba Rohani, Erwin W Gelfand, Nima Rezaei, Amir Hossein Abdolghaffari
Inflammatory bowel disease (IBD) is the chronic inflammation of the gastrointestinal tract. Recently, studies of the interplay between the adaptive and innate immune responses have provided a better understanding of the immunopathogenesis of inflammatory disorders such as IBD, as well as identification of novel targets for more potent interventions. Toll-like receptors (TLRs) are a class of proteins that play a significant role in the innate immune system and are involved in inflammatory processes. Activation of TLR signal transduction pathways lead to the induction of numerous genes that function in host defense, including those for inflammatory cytokines, chemokines, and antigen presenting molecules...
November 16, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29155219/complement-anaphylatoxins-c3a-and-c5a-emerging-roles-in-cancer-progression-and-treatment
#17
REVIEW
Daniel Ajona, Sergio Ortiz-Espinosa, Ruben Pio
Recent insights into the role of complement anaphylatoxins C3a and C5a in cancer provide new opportunities for the development of innovative biomarkers and therapeutic strategies. These two complement activation products can maintain chronic inflammation, promote an immunosuppressive microenvironment, induce angiogenesis, and increase the motility and metastatic potential of cancer cells. Still, the diverse heterogeneity of responses mediated by these peptides poses a challenge both to our understanding of the role played by these molecules in cancer progression and to the development of effective treatments...
November 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29155187/when-chemotherapy-is-not-enough-management-of-prostatic-embryonal-rhabdomyosarcoma-in-an-infant
#18
Christina Carpenter, Joseph M Gleason
A baby boy was diagnosed with embryonal rhabdomyosarcoma causing left hydroureteronephrosis. A loop ureterostomy was performed, and he was treated per the RMS13 protocol. After three months of chemotherapy, his tumor burden increased, and he underwent radical cystoprostatectomy and right-to-left transureteroureterostomy (end-to-end fashion utilizing the distal limb of his ureterostomy). This innovative method was utilized because the child's tumor burden was too large to be treated effectively and safely with radiation...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29155144/bay-60-2770-activates-two-isoforms-of-nitric-oxide-sensitive-guanylyl-cyclase-evidence-for-stable-insertion-of-activator-drugs
#19
Anne Sömmer, Peter Sandner, Sönke Behrends
Nitric oxide sensitive guanylyl cyclase (NOsGC), a hemoprotein and the major physiological receptor for nitric oxide (NO), is a heterodimer with the α1/β1 and α2/β1 isoforms known to be important for NO-signaling and conversion of GTP to cGMP in humans. Two innovative classes of compounds modulating the NO/cGMP signaling pathway have been discovered: the heme-dependent sGC stimulators, that stimulate NOsGC directly and also increase the affinity towards NO, and the heme-independent sGC activators, that are thought to bind to oxidized and heme-free NOsGC in tissues exposed to oxidative stress...
November 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29154677/express-an-innovative-approach-to-exploit-reflection-spectroscopy-of-liquid-characteristics
#20
Ran Pelta, Amihai Granot, Eyal Ben-Dor
No abstract text is available yet for this article.
January 1, 2017: Applied Spectroscopy
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