keyword
https://read.qxmd.com/read/38536627/fatal-intoxications-with-zopiclone-a-cause-for-concern
#21
JOURNAL ARTICLE
Lova Tralla, Sara Gustavsson, Carl Söderberg, Anna K Jönsson, Fredrik C Kugelberg
INTRODUCTION: Zopiclone, a controlled substance prescribed for insomnia, has become a common toxicological finding in forensic autopsy cases. This study investigated the role and extent of zopiclone use in fatal intoxications in Sweden. METHODS: All forensic autopsy cases positive for zopiclone in femoral blood during 2012-2020 were selected. Among these cases, fatalities caused by intoxication according to the cause of death certificates issued by the forensic pathologist were identified...
March 27, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38536619/acceptability-and-feasibility-of-the-plasma-separation-card-for-an-integrated-model-of-care-for-hbv-and-hcv-screening-among-people-attending-hiv-clinics-in-cameroon-and-uganda
#22
JOURNAL ARTICLE
Camila A Picchio, Aina Nicolàs, Ironne Valdèse Ayemfouo Fofou, Viola Kasone, Magellan Guewo-Fokeng, Claude T Tagny, Teddy Nanyonjo, Hellen Nansumba, Yves Nacel Kouongni, Rita Gaëlle Epse Sezawo Kamdjeu, Emmanuel Seremba, Charles Kouanfack, Isaac Ssewanyana, Richard Njouom, Ariadna Rando Segura, Francisco Rodríguez-Frías, Jean Claude Mbanya, Ponsiano Ocama, Jeffrey V Lazarus
BACKGROUND: Sub-Saharan African countries have a high burden of viral hepatitis and poor access to screening and care. The aim of this study was to evaluate the feasibility and acceptability of using the plasma separation card (PSC) for viral hepatitis B and C screening among people living with HIV (PLHIV) in Cameroon and Uganda. METHODS: This is a cross-sectional study carried out between 05/2021 and 03/2023 including 192 PLHIV in Cameroon (n = 104) and Uganda (n = 88)...
March 27, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38536597/exosomal-encapsulation-of-mir-3198-promotes-proliferation-and-migration-of-trophoblasts-in-preeclampsia
#23
JOURNAL ARTICLE
Yuchen Li, Yanling Yu, Dejun Li, Lei Li
PURPOSE: Preeclampsia (PE) is a vascular remodeling disorder cloesly linked to trophoblast dysfunction, involving defects in their proliferation, migration, and apoptosis. Maternal exosomal microRNAs (miRNAs) have been reported to play pivotal roles in the development of PE. However, the mechanism underlying the role of maternal exosomes in trophoblast dysfunction regarding the development of PE is poorly understood. METHODS: Plasma exosomes from maternal peripheral blood were collected from pregnant women with PE and from those with normal pregnancy...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38536557/non-contrast-mri-of-micro-vascularity-of-the-feet-and-toes
#24
JOURNAL ARTICLE
Won C Bae, Vadim Malis, Diana Vucevic, Asako Yamamoto, Katsumi Nakamura, John Lane, Mitsue Miyazaki
PURPOSE: This study aimed to develop novel non-contrast MR perfusion techniques for assessing micro-vascularity of the foot in human subjects. METHODS: All experiments were performed on a clinical 3 T scanner using arterial spin labeling (ASL). Seven healthy subjects (30-72 years old, 5 males and 2 females) were enrolled and bilateral feet were imaged with tag-on and tag-off alternating inversion recovery spin labeling for determining micro-vascularity...
March 27, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38536524/clinical-impact-and-cost-consequence-analysis-of-eplex%C3%A2-blood-culture-identification-panels-for-the-rapid-diagnosis-of-bloodstream-infections-a-single-center-randomized-controlled-trial
#25
JOURNAL ARTICLE
Yvan Caspar, A Deves, C Richarme, M Le Marechal, L Ponderand, A-L Mounayar, S Lejeune, J Arata-Bardet, M Gallouche, C Recule, D Maubon, C Garnaud, M Cornet, M Veloso, B Chabani, M Maurin, S David-Tchouda, P Pavese
To assess clinical impact and perform cost-consequence analysis of the broadest multiplex PCR panels available for the rapid diagnosis of bloodstream infections (BSI). Single-center, randomized controlled trial conducted from June 2019 to February 2021 at a French University hospital with an institutional antimicrobial stewardship program. Primary endpoint was the percentage of patients with optimized antimicrobial treatment 12 h after transmission of positivity and Gram stain results from the first positive BC...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536495/correction-to-histamine-h2%C3%A2-receptor-antagonism-improves-conduit-artery-endothelial-function-and-reduces-plasma-aldosterone-level-without-lowering-arterial-blood-pressure-in-angiotensin-ii-hypertensive-mice
#26
Kasper B Assersen, Boye L Jensen, Camilla Enggaard, Paul M Vanhoutte, Pernille B L Hansen
No abstract text is available yet for this article.
March 27, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38536494/the-role-of-na-coupled-bicarbonate-transporters-ncbt-in-health-and-disease
#27
REVIEW
Shannon R Holmberg, Yohei Sakamoto, Akira Kato, Michael F Romero
Cellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms.org/slc/ ). The SLC4 family of bicarbonate (HCO3 - ) transporters consists of ten members, sorted by their coupling to either sodium (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE), chloride (AE1, AE2, AE3), or borate (BTR1). The ionic coupling of SLC4A9 (AE4) remains controversial...
March 27, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38536440/circulating-catecholamines-endothelin-1-and-nitric-oxide-releases-do-not-explain-the-preserved-fmd-following-acute-resistance-exercise-in-strength-trained-men
#28
JOURNAL ARTICLE
Takuma Morishima, Nobukazu Kasai
PURPOSE: Acute resistance exercise decreases endothelial function in sedentary individuals but not in strength-trained (ST) individuals. However, the underlying mechanism(s) of vascular protection in ST individuals remains unclear. Herein, we compared catecholamines, endothelin-1 (ET-1), and nitric oxide (NOx) releases after acute resistance exercise between sedentary and ST individuals. METHODS: The untrained (UT) group comprised 12 male individuals with no regular training, while the ST group comprised 12 male individuals...
March 27, 2024: European Journal of Applied Physiology
https://read.qxmd.com/read/38536431/enhancing-safety-in-tumescent-liposuction-managing-sedation-related-respiratory-issues-and-serious-complications-under-deep-sedation-with-the-propofol-ketamine-protocol
#29
JOURNAL ARTICLE
Eun Ju Kim, Hyunju Kim, Younchan Park
BACKGROUND: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, it has limitations. There is no literature reported on semi-tumescent liposuction under deep sedation using the propofol-ketamine protocol, which is proposed as a potentially safe alternative. METHODS: The retrospective analysis covered 8 years and included 3094 patients performed for tumescent liposuction under deep sedation, utilizing the propofol-ketamine protocol...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38536062/finite-difference-embedded-unet-for-solving-transcranial-ultrasound-frequency-domain-wavefield
#30
JOURNAL ARTICLE
Linfeng Wang, Jian Li, Shili Chen, Zheng Fan, Zhoumo Zeng, Yang Liu
Transcranial ultrasound imaging assumes a growing significance in the detection and monitoring of intracranial lesions and cerebral blood flow. Accurate solution of partial differential equation (PDE) is one of the prerequisites for obtaining transcranial ultrasound wavefields. Grid-based numerical solvers such as finite difference (FD) and finite element methods have limitations including high computational costs and discretization errors. Purely data-driven methods have relatively high demands on training datasets...
March 1, 2024: Journal of the Acoustical Society of America
https://read.qxmd.com/read/38536038/impaired-muscle-oxygenation-despite-normal-pulmonary-function-in-uncomplicated-type-2-diabetes
#31
JOURNAL ARTICLE
Islem Jlali, Imen Touil, Hassen Ibn Hadj Amor, Mohamed Amine Bouzid, Omar Hammouda, Elsa Heyman, Pierre Fontaine, Hamdi Chtourou, Remi Rabasa-Lhoret, Georges Baquet, Semah Tagougui
Long-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation...
March 27, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38535892/reconsidering-coronary-circulation-in-the-era-of-lv-unloading-the-underlying-physiology-in-the-non-physiological-setting
#32
JOURNAL ARTICLE
Masafumi Fukumitsu, Keita Saku
No abstract text is available yet for this article.
March 27, 2024: Journal of Physiology
https://read.qxmd.com/read/38535771/intravoxel-incoherent-motion-diffusion-weighted-mri-fat-quantification-and-electromyography-correlation-in-polymyositis-and-dermatomyositis
#33
JOURNAL ARTICLE
Hyunjung Kim, Sang Yeol Yong, Chuluunbaatar Otgonbaatar, Seoung Wan Nam
(1) Background: The intravoxel incoherent motion (IVIM) model can provide information about both molecular diffusion and blood flow for the evaluation of skeletal muscle inflammation. MRI-based fat quantification is advantageous for assessing fat infiltration in skeletal muscle. (2) Purpose: We aimed to quantitatively measure various parameters associated with IVIM diffusion-weighted imaging (DWI) and fat quantification in the muscles of patients with polymyositis and dermatomyositis using magnetic resonance imaging and to investigate the relationship between these parameters and electromyography (EMG) findings...
March 1, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535518/acute-effects-of-various-doses-of-nitrate-rich-beetroot-juice-on-high-intensity-interval-exercise-responses-in-women-a-randomized-double-blinded-placebo-controlled-crossover-trial
#34
JOURNAL ARTICLE
Zhang Jiaqi, Dai Zihan, Stephen Heung-Sang Wong, Zheng Chen, Eric Tsz-Chun Poon
BACKGROUND: This study investigated the acute effects of various doses of nitrate-rich beetroot juice on the responses to high-intensity interval exercise in women. METHODS: A double-blinded, randomized, placebo-controlled, crossover trial was conducted with 13 recreationally active young women (age = 23 ± 2 years). All participants performed interval exercise (8 × 1-min bouts of cycling at 85% of peak power output [PPO] interspersed with 1-min active recovery at 20% of PPO) 2...
December 2024: Journal of the International Society of Sports Nutrition
https://read.qxmd.com/read/38535509/associations-of-valproate-doses-with-weight-gain-in-adult-psychiatric-patients-a-1-year-prospective-cohort-study
#35
JOURNAL ARTICLE
Claire Grosu, William Hatoum, Marianna Piras, Nermine Laaboub, Setareh Ranjbar, Franziska Gamma, Kerstin J Plessen, Armin von Gunten, Martin Preisig, Philippe Conus, Chin B Eap
Objective: The aim of this study was to evaluate valproate dose association with weight change, blood glucose, lipid levels, and blood pressure in a psychiatric population. Methods: Data from 215 patients taking valproate for up to 1 year were collected from 2 longitudinal studies that monitored metabolic variables between 2007 and 2022. Linear mixed-effect models and logistic regressions were used to analyze the associations between valproate doses and metabolic outcomes. Results: An increase in valproate dose of 500 mg was associated with a weight change of +0...
March 27, 2024: Journal of Clinical Psychiatry
https://read.qxmd.com/read/38535498/air-pollution-and-primary-dna-damage-among-zagreb-croatia-residents-a-cross-sectional-study
#36
JOURNAL ARTICLE
Marko Gerić, Gordana Pehnec, Katarina Matković, Jasmina Rinkovec, Ivana Jakovljević, Ranka Godec, Silva Žužul, Ivan Bešlić, Ante Cvitković, Luka Delić, Pascal Wild, Irina Guseva Canu, Nancy B Hopf, Goran Gajski
More than eight million premature deaths annually can be attributed to air pollution, with 99% of the world's population residing in areas below recommended air quality standards. Hence, the present study aimed to examine the association between primary DNA damage and air pollution data among 123 participants enrolled between 2011 and 2015 in Zagreb, Croatia. While most measured air pollutants adhered to regulatory limits, benzo[a]pyrene concentrations bound to PM10 exceeded them. Factorial analysis narrowed down air pollution data to four exposure factors (particulate matter, two metal factors, and other pollutants)...
March 13, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535432/assessment-of-the-relationship-between-periodontitis-and-cardiac-parameters-in-patients-with-early-chronic-heart-failure-a-cross-sectional-study
#37
JOURNAL ARTICLE
Antina Schulze, Stefan Kwast, Christoph Pökel, Martin Busse
Periodontal disease (PD) is considered a risk factor for cardiovascular events. However, its relationship to chronic heart failure (CHF) is unclear. The aim was to compare cardiac and inflammatory parameters in CHF patients with (PG) versus without periodontitis (NPG). The following parameters were recorded in 58 patients: periodontal screening and recording (PSR), troponin T, NT-proBNP, C-reactive protein (CRP), interleukin-6 (IL-6), blood pressure, heart rate, ejection fraction (EF), ventricular systolic and diastolic function parameters, incremental test, and three questionnaires (Mediterranean Diet Adherence Screener, MEDAS; Oral Health Impact Profile, OHIP-14; Patient Health Questionnaire, PHQ)...
March 18, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535413/effect-of-a-cross-training-and-resistance-exercise-routine-on-il-15-in-adults-with-type-b-acute-lymphoblastic-leukemia-during-the-induction-phase-randomized-pilot-study
#38
JOURNAL ARTICLE
Adán Germán Gallardo Rodríguez, Irma Olarte Carrillo, Adolfo Martínez Tovar, Rafael Cerón Maldonado, Emmanuel Martínez Moreno, Christian Omar Ramos Peñafiel
IL-15 is a proinflammatory myokine essential for activating NK cells and CD8+ T lymphocytes, and its overexpression has been related to reducing overall survivorship in patients with acute lymphoblastic leukemia (ALL). Physical exercise has been shown to be safe, feasible, and beneficial in hematological cancers. Exercise requires the activation of muscles that secrete cytokines, such as IL-15, causing immune mobilization. The objective was to compare the outcomes of two training routines on IL-15 and survival prognosis in adult patients diagnosed with ALL...
December 21, 2023: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535138/an-improved-path-finding-method-for-the-tracking-of-centerlines-of-tortuous-internal-carotid-arteries-in-mr-angiography
#39
JOURNAL ARTICLE
Se-On Kim, Yoon-Chul Kim
Centerline tracking is useful in performing segmental analysis of vessel tortuosity in angiography data. However, a highly tortuous) artery can produce multiple centerlines due to over-segmentation of the artery, resulting in inaccurate path-finding results when using the shortest path-finding algorithm. In this study, the internal carotid arteries (ICAs) from three-dimensional (3D) time-of-flight magnetic resonance angiography (TOF MRA) data were used to demonstrate the effectiveness of a new path-finding method...
February 28, 2024: Journal of Imaging
https://read.qxmd.com/read/38535131/cardiometabolic-risk-profiles-of-adolescents-living-with-perinatally-acquired-hiv-in-south-africa
#40
JOURNAL ARTICLE
Leonore Greybe, Shaun Barnabas, Mark Cotton, Penelope Rose, Helena Rabie, Lisa Frigati
BACKGROUND: We assessed the Pathological Determinants of Atherosclerosis in Youth (PDAY) score and other potential cardiovascular disease risk factors in adolescents previously enrolled in the Children with HIV Early antiRetroviral (CHER) and International Maternal Pediatric Adolescent AIDS Clinical Trials Network P1060 clinical trials. METHODS: Coronary artery and abdominal aorta (AA) PDAY scores were calculated for 56 participants over 15 years of age using a weighted combination of dyslipidemia, cigarette smoking, hypertension, obesity, and hyperglycemia...
March 26, 2024: Pediatric Infectious Disease Journal
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