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https://www.readbyqxmd.com/read/28644430/the-clinical-landscape-for-sma-in-a-new-therapeutic-era
#1
REVIEW
K Talbot, E F Tizzano
Despite significant advances in basic research, the treatment of degenerative diseases of the nervous system remains one of the greatest challenges for translational medicine. The childhood onset motor neuron disorder spinal muscular atrophy (SMA) has been viewed as one of the more tractable targets for molecular therapy, due to a detailed understanding of the molecular genetic basis of the disease. In SMA, inactivating mutations in the SMN1 gene can be partially compensated for by limited expression of SMN protein from a variable number of copies of the SMN2 gene, which provides both a molecular explanation for phenotypic severity and a target for therapy...
June 23, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28642676/international-society-of-sports-nutrition-position-stand-protein-and-exercise
#2
REVIEW
Ralf Jäger, Chad M Kerksick, Bill I Campbell, Paul J Cribb, Shawn D Wells, Tim M Skwiat, Martin Purpura, Tim N Ziegenfuss, Arny A Ferrando, Shawn M Arent, Abbie E Smith-Ryan, Jeffrey R Stout, Paul J Arciero, Michael J Ormsbee, Lem W Taylor, Colin D Wilborn, Doug S Kalman, Richard B Kreider, Darryn S Willoughby, Jay R Hoffman, Jamie L Krzykowski, Jose Antonio
The International Society of Sports Nutrition (ISSN) provides an objective and critical review related to the intake of protein for healthy, exercising individuals. Based on the current available literature, the position of the Society is as follows:An acute exercise stimulus, particularly resistance exercise, and protein ingestion both stimulate muscle protein synthesis (MPS) and are synergistic when protein consumption occurs before or after resistance exercise.For building muscle mass and for maintaining muscle mass through a positive muscle protein balance, an overall daily protein intake in the range of 1...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28642381/chemical-transformation-of-xenobiotics-by-the-human-gut-microbiota
#3
REVIEW
Nitzan Koppel, Vayu Maini Rekdal, Emily P Balskus
The human gut microbiota makes key contributions to the metabolism of ingested compounds (xenobiotics), transforming hundreds of dietary components, industrial chemicals, and pharmaceuticals into metabolites with altered activities, toxicities, and lifetimes within the body. The chemistry of gut microbial xenobiotic metabolism is often distinct from that of host enzymes. Despite their important consequences for human biology, the gut microbes, genes, and enzymes involved in xenobiotic metabolism are poorly understood...
June 23, 2017: Science
https://www.readbyqxmd.com/read/28640722/stroke-ineffective-tube-securement-reduces-nutrition-and-drug-treatment
#4
Sophie Brazier, Stephen J Taylor, Kaylee Allan, Rowan Clemente, Deirdre Toher
Stroke patients with dysphagia often depend on nutrition, hydration and medication via nasogastric (NG) feeding tubes. Securing tubes using tape is associated with repeated tube loss. In this study, the authors determined cause and effect by auditing tube placement methods, delays incurred, duration and costs. Of 202 NG tube placements in 75 patients, 67 placements occurred in 17 patients over a full course of enteral nutrition (EN) and 40 of these placements were tracked. Tubes were secured by tape in 100%, mittens 31% and special observation 5...
June 22, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28639040/mobile-gastrointestinal-and-endoscopic-surgery-in-rural-ecuador-20%C3%A2-years-experience-of-cinterandes
#5
H T Shalabi, M D Price, S T Shalabi, E B Rodas, A L Vicuña, B Guzhñay, R R Price, E Rodas
INTRODUCTION: Five billion people worldwide do not have timely access to surgical care. Cinterandes is one of the only mobile surgical units in low- and middle-income countries. This paper examines the methodology that Cinterandes uses to deliver mobile surgery. METHODS: Founding and core staff were interviewed, four missions were participated in, and internal documents and records were analysed between 1 May and 1 July 2014. RESULTS: Cinterandes performed 7641 operations over the last 20 years (60% gastrointestinal/laparoscopic), travelling 300,000 km to remote areas of Ecuador...
June 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28637506/improved-%C3%AE-linolenic-acid-production-in-mucor-circinelloides-by-homologous-overexpressing-of-delta-12-and-delta-6-desaturases
#6
Yao Zhang, Xiao Luan, Huaiyuan Zhang, Victoriano Garre, Yuanda Song, Colin Ratledge
BACKGROUND: γ-Linolenic acid (GLA) is important because of its nutritional value and medicinal applications. Although the biosynthetic pathways of some plant and microbial GLA have been deciphered, current understanding of the correlation between desaturases and GLA synthesis in oleaginous fungi is incomplete. In previous work, we found that a large amount of oleic acid (OA) had not been converted to linoleic acid (LA) or GLA in Mucor circinelloides CBS 277.49, which may be due to inadequate activities of the delta-12 or delta-6 desaturases, and thus leading to the accumulation of OA and LA...
June 21, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28637073/-complementary-and-alternative-medicine-in-oncology-what%C3%A2-makes-sense
#7
Axel Eustachi, Dieter Melchart
The basis of any complementary therapy should be the recommendation of a healthy lifestyle (diet, nutrition, exercise, stress-reduction), and appropriate self-help techniques (e. g. thermotherapy, herbal OTC-products) aimed at releasing the patients' most debilitating symptoms. For therapy-resistant or strong symptoms, more invasive interventions or medical treatments with an acceptable evidence base can be used (e. g. acupuncture for cancer pain, herbal prescriptions). The effects of any complementary intervention should be controlled for a period of six weeks after its administration...
June 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28633539/a-survey-on-chemical-constituents-and-indications-of-aromatic-waters-soft-drinks-hydrosols-used-in-persian-nutrition-culture-and-folk-medicine-for-neurological-disorders-and-mental-health
#8
Azadeh Hamedi, Ardalan Pasdaran, Zahra Zebarjad, Mahmoodreza Moein
In Persian nutrition culture, drinking aromatic waters (hydrosols, distillate) has a long history as functional beverages or therapeutic remedies. The co-distilled water with essential oils, which contains partial amounts of more water-soluble volatile compounds are diluted and used as beverages. Since the solubility of volatile components is different in water, the overall composition, and thus the biological activities of aromatic waters seem to be different from the essential oils they were co-distilled with...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28627843/using-the-headsss-guide-to-teach-students-diagnostic-skills-in-adolescent-health-views-from-students-participating-in-interprofessional-courses
#9
Vanessa Parisi, Léo Meyer De Stadelhofen, Benoit Péchère, Sylvain Steimer, Aude De Watteville, Dagmar M Haller, Carol Navarro, Murielle Szynalski-Morel, Anne Meynard
Over the past few years, an interprofessional team of lecturers in Geneva has developed courses entitled « adolescent health and development ». These courses are open to students in medicine, nursing and nutrition, as well as to other interested health professionals. Using vignettes, students who participated in the courses present their thoughts on the use of the HEADSSS interview guide in the diagnostic approach with adolescents. These optional courses provide an opportunity to explore infrequently taught domains of the curriculum in a creative way...
May 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28625248/-core-knowledge-and-skill-based-approach-to-subspecialty-construction-in-critical-intensive-care-medicine-with-distinct-chinese-peculiarity
#10
Lijun Wang, Fang Tian
With the rapid development of critical care medicine (CCM) in China, there are increases in the number of intensive care units (ICUs), the scale of one center ICU and the team. Subspecialty construction of CCM is of great concerns for personnel training as well as discipline development, and is currently one of the urgent problems that need to be resolved. Experience of CCM subspecialty construction from Europe and the United States is lacking and it is necessary to propose some opinions on innovation to construct CCM subspecialties with Chinese characteristics...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28618650/anti-amnesic-effects-of-ganoderma-species-a-possible-cholinergic-and-antioxidant-mechanism
#11
Ravneet Kaur, Varinder Singh, Richa Shri
Mushrooms are valued for their nutritional as well as medicinal properties. Ganoderma species are used traditionally to treat neurological disorders but scientific evidence for this is insufficient. The present study was designed to systematically evaluate the anti-amnesic effect of selected Ganoderma species i.e. G. mediosinense and G. ramosissimum. Extracts of selected mushroom species were evaluated for their antioxidant activity and acetylcholinesterase (AChE) inhibition using in-vitro assays (DPPH and Ellman tests respectively)...
June 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28616041/efficacy-of-intraorbital-electroacupuncture-for-diabetic-abducens-nerve-palsy-study-protocol-for-a-prospective-single-center-randomized-controlled-trial
#12
Ling-Yun Zhou, Xue-Mei Li, Tie-Juan Liu, Xiao-Jie Ji, Ming Zhao, Chang Su, Ji-Chao Liu, Jiang-Yun Sun
Abducens nerve palsy (ANP) is commonly seen in patients with diabetes mellitus. The validity of acupuncture as a traditional Chinese medicine method in peripheral nerve repair is well established. However, its efficacy in randomized controlled trials remains unclear. Herein, we designed a protocol for a prospective, single-center, randomized controlled trial to investigate the effect of intraorbital electroacupuncture on diabetic ANP. We plan to recruit 60 patients with diabetic ANP, and randomly divide them into treatment and control groups...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28615996/international-society-of-sports-nutrition-position-stand-safety-and-efficacy-of-creatine-supplementation-in-exercise-sport-and-medicine
#13
REVIEW
Richard B Kreider, Douglas S Kalman, Jose Antonio, Tim N Ziegenfuss, Robert Wildman, Rick Collins, Darren G Candow, Susan M Kleiner, Anthony L Almada, Hector L Lopez
Creatine is one of the most popular nutritional ergogenic aids for athletes. Studies have consistently shown that creatine supplementation increases intramuscular creatine concentrations which may help explain the observed improvements in high intensity exercise performance leading to greater training adaptations. In addition to athletic and exercise improvement, research has shown that creatine supplementation may enhance post-exercise recovery, injury prevention, thermoregulation, rehabilitation, and concussion and/or spinal cord neuroprotection...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28609121/alleviatory-effect-of-spent-pleurotus-eryngii-quel-substrate-on-replant-problem-of-rehmannia-glutinosa-libosch
#14
Bao Zhang, Xuanzhen Li, Liuji Zhang, Li Gu, Fajie Feng, Ming-Jie Li, Fengji Wang, Wenxiong Lin, Zhong-Yi Zhang
Rehmannia glutinosa Libosch. is a medicinal plant cultivated at a commercial scale in China. However, replanting problems result in a severe decline in both the biomass and quality of its roots which are of greatest medicinal value. This study attempted to remediate the replant soil using spent Pleurotus eryngii Quel substrate for alleviating this issue, and to investigate the underlying mechanisms. Results showed that R. glutinosa grew successfully in fresh soil and remedial replant soil, while no roots were harvested in the unremedied replant soil...
June 13, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28608797/bioactive-mushroom-polysaccharides-a-review-on-monosaccharide-composition-biosynthesis-and-regulation
#15
REVIEW
Qiong Wang, Feng Wang, Zhenghong Xu, Zhongyang Ding
Mushrooms are widely distributed around the world and are heavily consumed because of their nutritional value and medicinal properties. Polysaccharides (PSs) are an important component of mushrooms, a major factor in their bioactive properties, and have been intensively studied during the past two decades. Monosaccharide composition/combinations are important determinants of PS bioactivities. This review summarizes: (i) monosaccharide composition/combinations in various mushroom PSs, and their relationships with PS bioactivities; (ii) possible biosynthetic pathways of mushroom PSs and effects of key enzymes on monosaccharide composition; (iii) regulation strategies in PS biosynthesis, and prospects for controllable biosynthesis of PSs with enhanced bioactivities...
June 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28605342/compositional-differences-of-the-winter-culinary-medicinal-mushroom-flammulina-velutipes-agaricomycetes-under-three-types-of-light-conditions
#16
Shu-Yao Tsai, Erh-Wen Huang, Chun-Ping Lin
The focus of this study was to investigate the effect of light on the cultivation and the amounts of bio-active components in Flammulina velutipes. The mushrooms were cultivated under fluorescent tube (T8) grow lights, lightemitting diodes (LEDs), and cold-cathode fluorescent lamps. The biological efficiency of the T8 lights was the highest, at 92%. The crude fat content, crude fiber content, polysaccharide content, and ergosterol content were highest under the LEDs, at 2.9 g/100 g, 7.9 g/100 g, 3.9 g/100 g, and 1...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28605326/effect-of-different-proportions-of-agrowaste-on-cultivation-yield-and-nutritional-composition-of-the-culinary-medicinal-jelly-mushroom-auricularia-polytricha-higher-basidiomycetes
#17
Chiu-Yeh Wu, Chih-Hung Liang, Kuan-Jzen Wu, Hsin-Der Shih, Zeng-Chin Liang
In this study, Auricularia polytricha was cultivated on a sawdust basal substrate supplemented with different proportions (30%, 45%, and 60%, respectively) of agrowastes-sugarcane bagasse (SB), rice straw (RS), and rice husk (RH)-to evaluate the alternative substrates. The mycelial growth rate, total colonization time, time to first primordia, biological efficiency, and chemical composition of the fruiting bodies were determined. Results indicated that the 60% SB substrate was the best substrate for mycelial growth of A...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28597827/inflammatory-bowel-disease-in-childhood-and-adolescence
#18
Jan Däbritz, Patrick Gerner, Axel Enninger, Martin Claßen, Michael Radke
BACKGROUND: The incidence of inflammatory bowel disease (IBD) in childhood and adolescence is 5-11 cases per 100 000 persons per year, corresponding to a new diagnosis of IBD in 800-1470 patients in Germany each year. METHODS: This review is based on pertinent publications retrieved by a selective search in PubMed, including guidelines from Germany and abroad. RESULTS: Children and adolescents with IBD often have extensive involvement and an aggressive course of disease...
May 12, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28597822/fungi-that-infect-humans
#19
Julia R Köhler, Bernhard Hube, Rosana Puccia, Arturo Casadevall, John R Perfect
Fungi must meet four criteria to infect humans: growth at human body temperatures, circumvention or penetration of surface barriers, lysis and absorption of tissue, and resistance to immune defenses, including elevated body temperatures. Morphogenesis between small round, detachable cells and long, connected cells is the mechanism by which fungi solve problems of locomotion around or through host barriers. Secretion of lytic enzymes, and uptake systems for the released nutrients, are necessary if a fungus is to nutritionally utilize human tissue...
June 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28597400/gynecologic-oncologists-attitudes-and-practices-relating-to-integrative-medicine-results-of-a-nationwide-ago-survey
#20
Evelyn Klein, Matthias W Beckmann, Werner Bader, Cosima Brucker, Gustav Dobos, Dorothea Fischer, Volker Hanf, Annette Hasenburg, Sebastian M Jud, Matthias Kalder, Marion Kiechle, Sherko Kümmel, Andreas Müller, Myrjam-Alice T Müller, Daniela Paepke, Andre-Robert Rotmann, Florian Schütz, Anton Scharl, Petra Voiss, Markus Wallwiener, Claudia Witt, Carolin C Hack
PURPOSE: The growing popularity and acceptance of integrative medicine is evident both among patients and among the oncologists treating them. As little data are available regarding health-care professionals' knowledge, attitudes, and practices relating to the topic, a nationwide online survey was designed. METHODS: Over a period of 11 weeks (from July 15 to September 30, 2014) a self-administered, 17-item online survey was sent to all 676 members of the Research Group on Gynecological Oncology (Arbeitsgemeinschaft Gynäkologische Onkologie) in the German Cancer Society...
June 8, 2017: Archives of Gynecology and Obstetrics
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