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Shu-Hong Zhang, Fen-Yan An, Ji-Xin Xu, Ling-Jun Kong, Hai-Long He, Yi-Huan Chai, Wen-Lin Zhao
OBJECTIVE: To explore the clinical features and prognostic factors of pediatric acute lymphoblastic leukemia (ALL) in high-risk (HR) group. METHODS: A total of 421 children with ALL in the Children's Hospital of Soochow University from August 2008 to March 2013 were diagnosed and treated according to the Chinese Children Leukemia Group (CCLG)-2008 Protocol. Among different risk-groups, 148 cases were stratified into the low-risk group and 191 cases were included in the moderate-risk group...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
Hirotake Tsukamoto, Koji Fujieda, Masatoshi Hirayama, Tokunori Ikeda, Akira Yuno, Keiko Matsumura, Daiki Fukuma, Kimi Araki, Hiroshi Mizuta, Hideki Nakayama, Satoru Senju, Yasuharu Nishimura
IL6 produced by tumor cells promotes their survival, conferring a poor prognosis in patients with cancer. IL6 also contributes to immunosuppression of CD4(+) T cell-mediated antitumor effects. In this study, we focused on the impact of IL6 trans-signaling mediated by soluble IL6 receptors (sIL6R) expressed in tumor-bearing hosts. Higher levels of sIL6R circulating in blood were observed in tumor-bearing mice, whereas the systemic increase of sIL6R was not prominent in tumor-bearing mice with myeloid cell-specific conditional deletion of IL6R even when tumor cells produced sIL6R...
February 24, 2017: Cancer Research
George Markousis-Mavrogenis, Luis Eduardo Juárez-Orozco, Erick Alexanderson
BACKGROUND/INTRODUCTION/AIM: Positron Emission Tomography (PET) is the gold standard for quantification of Myocardial Blood Flow (MBF). A standard PET scan is acquired in two phases (rest and pharmacological stress). (13)N-ammonia is a perfusion radiotracer that may show residual activity which may affect MBF estimation during the second phase of the scan. An algorithm for Residual Activity Correction (RAC) is available when reconstruction is performed using Syngo MBF (by Siemens). The aim of this study was to evaluate differentes in MBF estimation with and without RAC by Syngo MBF in patients with a previous MI using (13)N-ammonia PET...
January 27, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
Dharmalingam Subramaniam, Gaurav Kaushik, Prasad Dandawate, Shrikant Anant
Pancreatic ductal adenocarcinoma is one of the deadliest cancers worldwide and the fourth leading cause of cancer-related deaths in United States. Regardless of the advances in molecular pathogenesis and consequential efforts to suppress the disease, this cancer remains a major health problem in United States. By 2030, the projection is that pancreatic cancer will be climb up to be the second leading cause of cancer-related deaths in the United States. Pancreatic cancer is a rapidly invasive and highly metastatic cancer, and does not respond to standard therapies...
January 26, 2017: Current Medicinal Chemistry
Juan-Juan Wang, Xiao-Ning Gao, Shan-Shan Chen, Pan-Pan Zhang, Tao Wang, Hao-Ying Dou
Muscle-derived stem cells (MDSC) are a population of multipotent stem cells in the muscular tissue. It provide an excellent prospect of hemopathy treatment due to their superiorities, such as rich sources, convenient material resource and a high survival rate after transplantation and so on. However, there are great differences in sampling, separation, purification, and proliferation when MDSC were cultured in vitro. In addition, the proliferation conditions of the MDSC in vitro are yet unclear. The related regulatory mechanisms, which MDSC transformed into haematopoietic cells, need to be investigated...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Michelle Maroto, Laura Aylsworth
This paper investigates wealth disparities among first-generation immigrants using data from the 2012 Survey of Financial Security. We apply logistic and linear regression models to estimate disparities in homeownership and household equivalent net worth by immigrant status, region of origin, and time since arrival. By focusing on immigrant families from different regions who entered Canada at different points in time, this research applies theories related to assimilation, human capital, and structural barriers to wealth...
November 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
Abdolmohammad Kazemipur
In much of the academic debate on the integration of Muslims into Western liberal democracies, Islam is often treated as one or the sole independent variable in the lives of Muslims. Offering to view Islam-or the understanding of Islam among Muslims-as the dependent variable, The Muslim Question in Canada discusses the influence of socioeconomic forces in shaping the Muslim immigrants' opinions, modes of thinking, and even interpretations of their faith. Drawing on this general approach, which is introduced and developed in the book using a variety of both quantitative and qualitative data, this article focuses on a school of thought within the Islamic jurisprudence known as fiqh al-aqalliyyat al-Muslema (the jurisprudence of Muslim minorities)...
November 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
Hongfei Ge, Anyong Yu, Jingyu Chen, Jichao Yuan, Yi Yin, Wangsheng Duanmu, Liang Tan, Yang Yang, Chuan Lan, Weixiang Chen, Hua Feng, Rong Hu
The recruitment of neural stem/progenitor cells (NSPCs) for brain restoration after injury is a promising regenerative therapeutic strategy. This strategy involves enhancing proliferation, migration and neuronal differentation of NSPCs. To date, the lack of biomaterials, which facilitate these processes to enhance neural regeneration, is an obstacle for the cell replacement therapies. Our previous study has shown that NSPCs grown on poly-L-ornithine (PO) could proliferate more vigorously and differentiate into more neurons than that on Poly-L-Lysine (PLL) and Fibronectin (FN)...
November 22, 2016: Scientific Reports
J Tayierjiang, N Waresijiang, H Wang
Objective: To evaluate the clinical results of the patients with severe kyphosis and paraplegia in different spine segment due to tuberculosis of thoracic and lumbar had been treated by one stage posterior surgical procedure to debriment of lesion and titian mesh bone fusion with internal fixation by pedicle screw system. Method: From May 2008 to March 2014, there were total 30 patients with severe kyphosis and paraplegia in different spine segment due to tuberculosis of thoracic and lumbar in Department of Orthopaedics, the People's Hospital of Xinjiang Uygur Autonoumy Region...
October 11, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Małgorzata Pietrusińska, Aneta Pająk, Paweł Górski, Piotr Kuna, Janusz Szemraj, Agnieszka Goździńska-Nielepkowicz, Tadeusz Pietras
INTRODUCTION: The asthma- and chronic obstructive pulmonary disease (COPD)-related morbidity has been increasing during the recent years. Both asthma and COPD are diseases of inflammatory etiology. The increasing interest in the pathomechanisms involved in the development of obstructive pulmonary diseases seems to be fully justified. Recent research has attempted to determine the associations of microRNA with the pathogenesis of pulmonary diseases. AIM: To assess the expression of microRNA in the blood sera of patients diagnosed with bronchial asthma and chronic obstructive pulmonary disease in comparison with healthy subjects...
August 2016: Postȩpy Dermatologii i Alergologii
Emily Milne
Student success is facilitated by strong bonds between families and schools, including a shared sense of purpose and mutual trust. However, for Indigenous peoples these relationships are often broken, undermined by the legacy of residential schooling and assimilative educational practices. Drawing on interviews with 50 Indigenous (mainly Haudenosaunee, Anishinaabe, and Métis) and non-Indigenous parents and educators, this paper examines the ways in which issues of class and race shape interactions between teachers and Indigenous parents...
2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
Sang-Il Ahn, Ji-Soo Kim, Gyo-Jeong Gu, Hyeon-Myeong Shin, Ah-Yeon Kim, Hyun-Jin Shim, Yeon Joo Kim, Kwang Oh Koh, Joo Yang Mang, Dae Young Kim, Hyung-Sun Youn
Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS) and triggers the activation of myeloid differention factor 88 (MyD88) and the Toll/interleukin-1 receptor domain-containing adapter, inducing interferon-β (TRIF)-dependent major downstream signaling pathways. To evaluate the therapeutic potential of 1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine (MNP), previously synthesized in our laboratory, its effect on signal transduction via the TLR signaling pathways was examined. Here, we investigated whether MNP modulates the TLR4 signaling pathways and which anti-inflammatory target in TLR4 signaling is regulated by MNP...
October 2016: Archiv der Pharmazie
J Z Tan, E M Nie, C Y Zhang, R Jiang
OBJECTIVE: To investigate the effect of zinc ion on the expression of osteoblastic proteins. METHODS: Mice osteoblasts MC3T3-E1 cells were subcultured. Inflammatory environment model was established by tumor necrosis factor α(TNF-α)at a concentration of 10 mg/L. According to different concentration of Zn(2+), the cells were divided into TNF-α group, control group, group A(TNF-α+10(-4) mol/L Zn(2+)), group B(TNF-α+10(-5) mol/L Zn(2+)), group C(TNF-α+10(-6) mol/L Zn(2+))...
August 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Marie-Claire Lévesque, Natalie Le Sage, Simon Berthelot, Valérie Boucher, Éric Mercier, Marcel Émond
UNLABELLED: Objectif Notre objectif primaire est de mesurer l'incidence d'HPI selon quatre définitions différentes retrouvées dans la littérature. Notre principal objectif secondaire est d'évaluer l'impact de la présence d'instabilité hémodynamique avant l'intubation sur l'incidence d'HPI. Le deuxième objectif secondaire consiste à déterminer l'incidence de l'HPI en fonction de l'intervalle de temps durant lequel la première hypotension survient. Méthode Une cohorte prospective a été constituée par les patients intubés en salle de réanimation à l'hôpital de l'Enfant-Jésus entre le 28/06/2011 et le 12/07/2012...
September 2016: CJEM
Aker Fügen, Sayman Elif, Gümrükçü Gülistan, Doğan Meryem, Gürleyik Günay
Myofibroblastoma (MFB) is a benign tumor of the mammary stroma with predominant myofibroblastic differention. The cytologic reports of MFB are very few in the available literature. From the cytodiagnostic point of view about 21 cases of MFB with cytological evaluation by fine-needle aspiration cytology (FNAC) have been encountered in the English-language literature: A 35-year-old woman presented with lump in the left breast. FNAC showed mild degree of pleomorphism with occasional groups with fibrous stroma and tumoral cells...
December 2016: Diagnostic Cytopathology
L Xu, L N Nwosu, J J Burston, P J Millns, D R Sagar, P I Mapp, P Meesawatsom, L Li, A J Bennett, D A Walsh, V Chapman
OBJECTIVE: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms contributing to the analgesic effects of anti-NGF antibody treatment in an established model of joint pain, which mimics key clinical features of OA. DESIGN: Effects of preventative vs therapeutic treatment with an anti-NGF antibody (monoclonal antibody 911: muMab 911 (10 mg/kg, s...
September 2016: Osteoarthritis and Cartilage
Sean Waite, Nicole Denier
This study presents novel evidence on the relationship between sexual orientation and self-employment. Using data from the 2001 and 2006 Census of Canada and the 2011 Canadian National Household Survey, we explore the propensity for self-employment among same- and opposite-sex couples. We examine the demographic, human capital, and family characteristics of coupled gay men and lesbians relative to their coupled heterosexual counterparts to offer potential mechanisms generating differences in rates of self-employment...
May 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
Masamitsu Eitoku, Narufumi Suganuma, Hidenori Kiyosawa
In vitro differentiation systems of mouse embryonic stem cells (ESCs) are widely used as tools for studies of cell differentiation, organogenesis, and regenerative medicine. We have studied the regulation of neuron-specific imprinting genes, Ube3a and its antisense transcripts (Ube3a ATS), using in vitro neuronal differentiation of F1 hybrid ESCs. Each different non-adherent plate used for embryoid body (EB) formation during differentiation is associated with different costs; notably, plates coated with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer are more expensive than untreated polystyrene plates...
December 2016: Cytotechnology
S Vienberg, J Geiger, S Madsen, L T Dalgaard
MicroRNAs (miRNAs) have within the past decade emerged as key regulators of metabolic homoeostasis. Major tissues in intermediary metabolism important during development of the metabolic syndrome, such as β-cells, liver, skeletal and heart muscle as well as adipose tissue, have all been shown to be affected by miRNAs. In the pancreatic β-cell, a number of miRNAs are important in maintaining the balance between differentiation and proliferation (miR-200 and miR-29 families) and insulin exocytosis in the differentiated state is controlled by miR-7, miR-375 and miR-335...
February 2017: Acta Physiologica
Yi Cui, Jin Han, Zhifeng Xiao, Tong Chen, Bin Wang, Bing Chen, Sumei Liu, Sufang Han, Yongxiang Fang, Jianshu Wei, Xiujie Wang, Xu Ma, Jianwu Dai
Increasing evidence suggests that three dimensional (3-D) cell cultures are an improvement over traditional two dimensional (2-D) cell cultures. Current researches have extensively focused on the study of utilizing biomaterial-based 3-D culture systems to study and direct stem-cell fate both in vitro and in vivo. Here in our study, we screened the differential expression patterns of miRNAs between 2-D cultured and 3-D cultured NPCs using microarray analysis. Among these differentially expressed miRNAs, miR-20 was found to increase during differentiation of NPCs...
March 21, 2016: Scientific Reports
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