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https://www.readbyqxmd.com/read/29775985/sensorimotor-exercises-and-enhanced-trunk-function-a-randomized-controlled-trial
#1
Steffen Mueller, Tilman Engel, Juliane Mueller, Josefine Stoll, Heiner Baur, Frank Mayer
The aim of this study was to investigate the effect of a 6-week sensorimotor or resistance training on maximum trunk strength and response to sudden, high-intensity loading in athletes.Forty-three healthy, well-trained participants were randomized into sensorimotor (SMT; n=11), resistance training (RT; n=16) and control groups (CG; n=16). Treatment groups received either sensorimotor training (SMT) or resistance training (RT) for 6 weeks, 3 times a week. At baseline and after 6 weeks of intervention, participants' maximum isokinetic strength in trunk rotation and extension was tested (concentric/eccentric 30°/s)...
May 18, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29773650/the-exercise-inducible-bile-acid-receptor-tgr5-improves-skeletal-muscle-function-in-mice
#2
Takashi Sasaki, Ayane Kuboyama, Moeko Mita, Shotaro Murata, Makoto Shimizu, Jun Inoue, Kazutoshi Mori, Ryuichiro Sato
TGR5 (also known as G protein-coupled bile acid receptor 1, GPBAR1) is a G protein-coupled bile acid receptor that is expressed in many diverse tissues. TGR5 is involved in various metabolic processes, including glucose metabolism and energy expenditure; however, TGR5's function in skeletal muscle is not fully understood. Using both gain- and loss-of-function mouse models, we demonstrate here that Tgr5 activation promotes muscle cell differentiation and muscle hypertrophy. Both young and old transgenic mice with muscle-specific Tgr5 expression exhibited increased muscle strength...
May 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29769816/the-effect-of-two-different-concurrent-training-programs-on-strength-and-power-gains-in-highly-trained-individuals
#3
Henrik Petré, Pontus Löfving, Niklas Psilander
The effects of concurrent strength and endurance training have been well studied in untrained and moderately-trained individuals. However, studies examining these effects in individuals with a long history of resistance training (RT) are lacking. Additionally, few studies have examined how strength and power are affected when different types of endurance training are added to an RT protocol. The purpose of the present study was to compare the effects of concurrent training incorporating either low-volume, high-intensity interval training (HIIT, 8-24 Tabata intervals at ~150% of VO2max ) or high-volume, medium-intensity continuous endurance training (CT, 40-80 min at 70% of VO2max ), on the strength and power of highly-trained individuals...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29767153/effect-of-phytase-superdosing-myo-inositol-and-available-phosphorus-concentrations-on-performance-and-bone-mineralisation-in-broilers
#4
Sophie A Lee, Devanaboyina Nagalakshmi, Mantina V L N Raju, Savaram V Rama Rao, Michael R Bedford
A total of 2,376 one-day-old Ross broiler chickens were used to investigate the effect of myo-inositol (MYO) and phytase supplementation on performance and bone mineralization variables in broilers fed diets formulated to have varying concentrations of available phosphorus (P). The trial was designed as a 2 × 2 × 3 factorial; with and without phytase superdosing (0 or 1,500 FTU/kg), MYO (0 or 3 g/kg), and dietary P (low, moderate or high). At 21 d, dietary phytase and MYO had no consistent benefit on bone mineralization variables...
September 2017: Animal nutrition
https://www.readbyqxmd.com/read/29766536/using-accelerated-drug-stability-results-to-inform-long-term-studies-in-shelf-life-determination
#5
Paul Faya, John W Seaman, James D Stamey
In the pharmaceutical industry, the shelf life of a drug product is determined by data gathered from stability studies and is intended to provide consumers with a high degree of confidence that the drug retains its strength, quality, and purity under appropriate storage conditions. In this paper, we focus on liquid drug formulations and propose a Bayesian approach to estimate a drug product's shelf life, where prior knowledge gained from the accelerated study conducted during the drug development stage is used to inform the long-term study...
May 15, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29761817/fermi-resonance-in-solvated-h-3-o-a-counter-intuitive-trend-confirmed-via-a-joint-experimental-and-theoretical-investigation
#6
Qian-Rui Huang, Tomoki Nishigori, Marusu Katada, Asuka Fujii, Jer-Lai Kuo
The spectral features of H3O+ between 3000 and 3800 cm-1 are known to be dominated by coupling between the fundamentals of stretching modes and the overtones of bending modes. A strong Fermi resonance (FR) pattern has been observed in Ar-tagged H3O+, and the sensitive dependence of the FR pattern on the number of Ar tags has been analyzed by Li et al. [J. Phys. Chem. A, 2015, 119(44), 10887]. Based on ab initio anharmonic calculations with MP2/aug-cc-pvDZ, Tan et al. investigated the influence of different types of rare gas and found a counter-intuitive trend that the strength of the coupling between the overtones of bending modes and the fundamentals of stretching modes decreases as the strength of solvation increases [Phys...
May 15, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29761054/is-high-intensity-interval-cycling-feasible-and-more-beneficial-than-continuous-cycling-for-knee-osteoarthritic-patients-results-of-a-randomised-control-feasibility-trial
#7
Justin W Keogh, Josephine Grigg, Christopher J Vertullo
Background: Knee osteoarthritis (OA) patients often suffer joint pain and stiffness, which contributes to negative changes in body composition, strength, physical performance (function), physical activity and health-related quality of life. To reduce these symptoms and side effects of knee OA, moderate-intensity continuous training (MICT) cycling is often recommended. While resistance training is considered the optimal form of training to improve sarcopenic outcomes, it imposes higher joint loads and requires supervision, either initially or continuously by trained exercise professionals...
2018: PeerJ
https://www.readbyqxmd.com/read/29760254/learning-narrative-based-medicine-skills-narrative-based-medicine-3
#8
REVIEW
George Zaharias
OBJECTIVE: To raise awareness of narrative-based medicine (NBM) as a valuable approach to the consultation, which, if practised more widely by GPs, would convey considerable benefits to both patient and doctor. SOURCES OF INFORMATION: While this article draws on the perspectives of 2 of NBM's key proponents, Rita Charon and John Launer, it also presents the author's perspective on the usefulness of the arts. MAIN MESSAGE: This article presents some practical ways in which GPs can start using the skills of NBM and methods for developing those skills further...
May 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29759951/immediate-and-long-term-results-of-unsintered-hydroxyapatite-and-poly-l-lactide-composite-sheets-for-orbital-wall-fracture-reconstruction
#9
Keishi Kohyama, Yoko Morishima, Koki Arisawa, Yuko Arisawa, Hisakazu Kato
INTRODUCTION: Bone defect reconstruction in orbital wall fractures with absorbable alloplastic such as the unsintered hydroxyapatite and poly L-lactide composite (u-HA/PLLA) system is gaining popularity. The u-HA/PLLA material has osteoconductive and osteosynthetic properties. However, quantitative, long-term outcome data after the use of u-HA/PLLA for orbital wall fractures are lacking. PATIENTS AND METHODS: We retrospectively analyzed 115 patients who underwent surgical repair of orbital wall fractures with a u-HA/PLLA sheet from 2011 to 2016...
March 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29758361/bone-accrual-in-oligo-amenorrheic-athletes-eumenorrheic-athletes-and-non-athletes
#10
Vibha Singhal, Karen Campoverde Reyes, Brooke Pfister, Kathryn Ackerman, Meghan Slattery, Katherine Cooper, Alexander Toth, Nupur Gupta, Mark Goldstein, Kamryn Eddy, Madhusmita Misra
BACKGROUND: Mechanical loading improves bone mineral density (BMD) and strength while decreasing fracture risk. Cross-sectional studies show that exercise advantage is lost in oligo-amenorrheic athletes (OA). Longitudinal studies examining the opposing effects of exercise and hypogonadism on bone are lacking in adolescents/young adults. OBJECTIVE: Evaluate differences in bone accrual over 12 months in OA, eumenorrheic athletes (EA) and non-athletes (NA). We hypothesized that bone accrual would be lower in OA than EA and NA, with differences most pronounced at non-weight bearing trabecular sites...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29758234/a-validation-of-dynamic-causal-modelling-for-7t-fmri
#11
S Tak, J Noh, C Cheong, P Zeidman, A Razi, W D Penny, K J Friston
BACKGROUND: There is growing interest in ultra-high field magnetic resonance imaging (MRI) in cognitive and clinical neuroscience studies. However, the benefits offered by higher field strength have not been evaluated in terms of effective connectivity and dynamic causal modelling (DCM). NEW METHOD: In this study, we address the validity of DCM for 7T functional MRI data at two levels. First, we evaluate the predictive validity of DCM estimates based upon 3T and 7T in terms of reproducibility...
May 11, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29751804/changes-in-physiotherapy-students-knowledge-and-perceptions-of-ebp-from-first-year-to-graduation-a-mixed-methods-study
#12
Maureen P McEvoy, Lucy K Lewis, Julie Luker
BACKGROUND: Dedicated Evidence-Based Practice (EBP) courses are often included in health professional education programs. It is important to understand the effectiveness of this training. This study investigated EBP outcomes in entry-level physiotherapy students from baseline to completion of all EBP training (graduation). METHODS: Mixed methods with an explanatory sequential design. Physiotherapy students completed two psychometrically-tested health professional EBP instruments at baseline and graduation...
May 11, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29745346/orodispersible-films-a-systematic-patent-review
#13
Ashwini Deshpande, Chaitrali Gijare
BACKGROUND: In Recent years, oral film technology is aimed by the research groups. Oral film technology (OFT) has gained much attention among all the oral drug delivery systems. Fast dissolving film, fast disintegrating film and orodispersible film are some alternative words for this dosage form. Without a need of liquid for administration this dosage form dissolves in the mouth. Typically, fast dissolving film dissolves from 1 to 30 seconds. OBJECTIVE: At the root of this originality, many researchers patented their work on the aspect of orodispersible films using different drugs, polymers, excipients and employing methods of preparation...
May 8, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29745292/unraveling-the-molecular-mechanism-of-benzothiophene-and-benzofuran-scaffold-merged-compounds-binding-to-anti-apoptotic-myeloid-cell-leukemia-1
#14
Parthiban Marimuthu, Kalaimathy Singaravelu
Myeloid cell leukemia 1 (Mcl1), is an anti-apoptotic member of the Bcl-2 family proteins, has gained considerable importance due to its overexpression activity prevents the oncogenic cells to undergo apoptosis. This overexpression activity of Mcl1 eventually develops strong resistance to a wide variety of anticancer agents. Therefore, designing novel inhibitors with potentials to elicit higher binding affinity and specificity to inhibit Mcl1 activity is of greater importance. Thus, Mcl1 acts as an attractive cancer target...
May 10, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29745275/animal-models-of-social-stress-the-dark-side-of-social-interactions
#15
Marianela Masis-Calvo, Anna K Schmidtner, Vinícius E de Moura Oliveira, Cindy P Grossmann, Trynke R de Jong, Inga D Neumann
Social stress occurs in all social species, including humans, and shape both mental health and future interactions with conspecifics. Animal models of social stress are used to unravel the precise role of the main stress system - the HPA axis - on the one hand, and the social behavior network on the other, as these are intricately interwoven. The present review aims to summarize the insights gained from three highly useful and clinically relevant animal models of psychosocial stress: the resident-intruder (RI) test, the chronic subordinate colony housing (CSC), and the social fear conditioning (SFC)...
May 10, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29740334/autonomic-differentiation-map-a-novel-statistical-tool-for-interpretation-of-heart-rate-variability
#16
Daniela Lucini, Nadia Solaro, Massimo Pagani
In spite of the large body of evidence suggesting Heart Rate Variability (HRV) alone or combined with blood pressure variability (providing an estimate of baroreflex gain) as a useful technique to assess the autonomic regulation of the cardiovascular system, there is still an ongoing debate about methodology, interpretation, and clinical applications. In the present investigation, we hypothesize that non-parametric and multivariate exploratory statistical manipulation of HRV data could provide a novel informational tool useful to differentiate normal controls from clinical groups, such as athletes, or subjects affected by obesity, hypertension, or stress...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29732497/uniform-polysaccharide-composite-microspheres-with-controllable-network-by-microporous-membrane-emulsification-technique
#17
Hongwu Zhang, Lan Zhao, Yongdong Huang, Kai Zhu, Qibao Wang, Rui Yang, Zhiguo Su, Guanghui Ma
High resolution has been constantly pursued in both preparative and analytical chromatography. Chromatographic media are a key factor during the entire separation process. Tailor-made chromatographic media have gained more attention because of their adjustable structure appropriate for application. Uniform polysaccharide composite microspheres were prepared with a mixture of agarose and dextran solution by membrane emulsification technique for the first time. Their pore structure was deliberately regulated by adjusting both the polysaccharide composition and the molecular weight of dextran...
May 7, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29732014/comparison-of-the-shear-bond-strength-of-silorane-based-composite-resin-and-methacrylate-based-composite-resin-to-mta
#18
Buse Ayse Serin, Muharrem Cem Dogan, Hamdi Oguz Yoldas
Background. Mineral trioxide aggregate (MTA) is a material that has recently gained popularity in the application of the vital pulp therapy. Along with the increasing use of MTA to this end, the permanent restoration material to be placed on MTA has become a significant issue. The aim of this in vitro study was to investigate the bond strength of the novel low-shrinkage silorane-based composite resin (SBC) to MTA. Methods. Twenty acrylic blocks filled with MTA were prepared for this study. SBC was the test group and methacrylate-based composite resin (MBC) was used as the control group...
2018: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/29730752/unilateral-wrist-extension-training-after-stroke-improves-strength-and-neural-plasticity-in-both-arms
#19
Yao Sun, Noah M H Ledwell, Lara A Boyd, E Paul Zehr
Stroke induces bilateral neurological impairment and muscle weakness yielding neurologically more (MA; paretic) and less affected (LA; non-paretic) sides. "Cross-education" refers to training one side of the body to increase strength in the same muscles on the untrained side. Past work showed dorsiflexion training of the LA side produced bilateral strength increases after stroke. The current study explored the presence and extent of cross-education after arm strength training in chronic stroke. Twenty-four chronic stroke participants completed 5 weeks of maximal wrist extension training using their LA arm...
May 5, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29729825/a-randomized-controlled-trial-of-an-intensive-nutrition-intervention-versus-standard-nutrition-care-to-avoid-excess-weight-gain-after-kidney-transplantation-the-intent-trial
#20
Cordula K Henggeler, Lindsay D Plank, Kristin J Ryan, Emily L Gilchrist, Jessie M Casas, Lyn E Lloyd, Laura E Mash, Sandra L McLellan, Jennifer M Robb, Michael G Collins
OBJECTIVE: Excessive weight gain is common after kidney transplantation and increases cardiovascular risk. The aim of this randomized controlled trial was to determine whether an intensive nutrition and exercise intervention delivered alongside routine post-transplant care would reduce post-transplant weight gain. DESIGN: Single-blind, randomized controlled trial. SUBJECTS AND SETTING: Adult kidney transplant recipients at a regional transplant center were recruited during routine outpatient clinic visits in the first month after transplant...
May 2, 2018: Journal of Renal Nutrition
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