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Contrast induced AKI

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https://www.readbyqxmd.com/read/29934555/hif-stabilization-inhibits-renal-epithelial-cell-migration-and-is-associated-with-cytoskeletal-alterations
#1
Simon Müller, Sonja Djudjaj, Janina Lange, Mihail Iacovescu, Margarete Goppelt-Struebe, Peter Boor
Acute kidney injury (AKI) is a common and potentially lethal complication in the hospitalized patients, with hypoxic injury being as a major cause. The loss of renal tubular epithelial cells (TEC), one of the AKI hallmarks, is potentially followed by tubular regeneration process orchestrated by the remaining uninjured TECs that undergo proliferation and migration. In this study, we used human primary TEC to investigate the initiation of tubular cell migration and associated cytoskeletal alterations in response to pharmacological HIF stabilization which resembles the pathophysiology of hypoxia...
June 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29932234/mir-26a-modulates-hgf-and-stat3-effects-on-the-kidney-repair-process-in-a-glycerol-induced-aki-model-in-rats
#2
Pedro Paulo Gattai, Edgar Maquigussa, Antonio da Silva Novaes, Rosemara da Silva Ribeiro, Vanessa Araújo Varela, Milene Subtil Ormanji, Mirian Aparecida Boim
Acute kidney injury is mostly reversible, and hepatocyte growth factor (HGF) has a relevant role in the tissue repair. MicroRNA (miR)-26a is an endogenous modulator of HGF. The role of miR-26a in the kidney repair process was evaluated in Wistar rats submitted to an acute kidney injury model of rhabdomyolysis induced by glycerol (6 mL/kg). Animals were evaluated 3, 12, 48, 96, and 120 hours after glycerol injection. Serum creatinine (SCr) and gene expression of HGF, c-met, signal transducer and activator of transcription 3 (STAT3), and miR-26a were estimated...
June 22, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29929842/left-ventricular-end-diastolic-pressure-and-contrast-induced-acute-kidney-injury-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention
#3
Fabio V Lima, Suraj Singh, Puja B Parikh, Luis Gruberg
BACKGROUND: Left ventricular end-diastolic pressure (LVEDP) reflects ventricular performance and volume status. We sought to analyze the relationship between LVEDP and the incidence of contrast-induced acute kidney injury (AKI) in patients with acute coronary syndrome undergoing percutaneous coronary intervention (PCI). METHODS: Between January 2006 and December 2008, a total of 254 patients presenting with an acute coronary syndrome had the LVEDP assessed prior to the intervention...
June 9, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29929610/bioimpedance-guided-hydration-for-the-prevention-of-contrast-induced-kidney-injury-the-hydra-study
#4
Mauro Maioli, Anna Toso, Mario Leoncini, Nicola Musilli, Gabriele Grippo, Claudio Ronco, Peter A McCullough, Francesco Bellandi
BACKGROUND: Intravascular volume expansion plays a major role in the prevention of contrast-induced acute kidney injury (CI-AKI). Recommended standard amounts of fluid infusion before procedures do not produce homogeneous responses in subjects with different initial hydration status. OBJECTIVES: The goal of this study was to compare the effect of standard and double intravenous (IV) infusion volumes in patients with low body fluid level, assessed by using bioimpedance vector analysis (BIVA), on the incidence of CI-AKI after elective coronary angiographic procedures...
June 26, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29925521/caspase-3-is-a-pivotal-regulator-of-microvascular-rarefaction-and-renal-fibrosis-after-ischemia-reperfusion-injury
#5
Bing Yang, Shanshan Lan, Mélanie Dieudé, Jean-Paul Sabo-Vatasescu, Annie Karakeussian-Rimbaud, Julie Turgeon, Shijie Qi, Lakshman Gunaratnam, Natalie Patey, Marie-Josée Hébert
Background Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different modes of programmed cell death in the tubular and microvascular compartments during the various stages of IRI-induced AKI, and their relative importance to renal fibrogenesis. Methods We performed unilateral renal artery clamping for 30 minutes and contralateral nephrectomy in wild-type mice (C57BL/6) or caspase-3-/- mice. Results Compared with their wild-type counterparts, caspase-3-/- mice in the early stage of AKI had high urine cystatin C levels, tubular injury scores, and serum creatinine levels...
June 20, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29909417/metabolic-syndrome-and-the-iodine-dose-creatinine-clearance-ratio-as-determinants-of-contrast-induced-acute-kidney-injury
#6
Ali Amiri, Reza Ghanavati, Hassan Riahi Beni, Seyyed Hashem Sezavar, Mehrdad Sheykhvatan, Mahsa Arab
BACKGROUND: Finding patients at risk of developing contrast-induced acute kidney injury (CI-AKI) is important because of its associated complications. In the present study, the contribution of different variables, such as the presence of metabolic syndrome (MetS), the volume creatinine clearance (V/CrCl) ratio, the iodine-dose (I-dose)/CrCl ratio, or hypertension, to CI-AKI was evaluated. METHODS: A total of 255 patients undergoing elective coronary angiography with or without intervention were enrolled and divided into a MetS and a control group...
June 15, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29906511/experimental-proliferative-vitreoretinopathy-in-rabbits-by-delivery-of-bioactive-proteins-with-gelatin-microspheres
#7
Fumitaka Hirose, Junichi Kiryu, Yasuhiko Tabata, Hiroshi Tamura, Kunihiro Musashi, Noriaki Takase, Hideaki Usui, Soichiro Kuwayama, Aki Kato, Nagahisa Yoshimura, Yuichiro Ogura, Tsutomu Yasukawa
Proliferative vitreoretinopathy (PVR) is a challenging pathological condition, often causing failure of retinal detachment surgery. The purpose of this study was to evaluate the feasibility of a delivery system of bioactive proteins using anionic and cationic gelatin microspheres and to establish a new PVR model in rabbits by intraocular sustained delivery of basic fibroblast growth factor (bFGF) and interferon-beta (IFNβ). Anionic and cationic gelatin microspheres were prepared and immersed in bFGF and IFNβ solution, respectively, to yield a polyion complex between gelatin matrix and a bioactive protein...
June 12, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29901713/s1p1-receptor-inhibits-kidney-epithelial-mesenchymal-transition-triggered-by-ischemia-reperfusion-injury-via-the-pi3k-akt-pathway
#8
Weina Wang, Aimei Wang, Guochang Luo, Fengqiao Ma, Xiaoming Wei, Yongyi Bi
Ischemia/reperfusion (I/R) is a major cause of acute kidney injury (AKI), along with delayed graft function, which can trigger chronic kidney injury by stimulating epithelial to mesenchymal transition (EMT) in the kidney canaliculus. Sphingosine 1-phosphate receptor 1 (S1P1) is a G protein-coupled receptor that is indispensable for vessel homeostasis. This study aimed to investigate the influence of S1P1 on the mechanisms underlying I/R-induced EMT in the kidney using in vivo and in vitro models. Wild-type (WT) and S1P1-overexpressing kidney canaliculus cells were subject to hypoxic conditions followed by reoxygenation in the presence or absence of FTY720-P, a potent S1P1 agonist...
June 13, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29898963/kidney-proximal-tubular-tlr9-exacerbates-ischemic-acute-kidney-injury
#9
Sang Jun Han, Hongmei Li, Mihwa Kim, Mark J Shlomchik, H Thomas Lee
The role for kidney TLR9 in ischemic acute kidney injury (AKI) remains unclear. In this study, we tested the hypothesis that renal proximal tubular TLR9 activation exacerbates ischemic AKI by promoting renal tubular epithelial apoptosis and inflammation. To test this hypothesis, we generated mice lacking TLR9 in renal proximal tubules (TLR9fl/fl PEPCK Cre mice). Contrasting previous studies in global TLR9 knockout mice, mice lacking renal proximal tubular TLR9 were protected against renal ischemia/reperfusion (IR) injury, with reduced renal tubular necrosis, inflammation (decreased proinflammatory cytokine synthesis and neutrophil infiltration), and apoptosis (decreased DNA fragmentation and caspase activation) when compared with wild-type (TLR9fl/fl ) mice...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29897643/cest-mri-of-sepsis-induced-acute-kidney-injury
#10
Jing Liu, Zheng Han, Guoli Chen, Yuguo Li, Jia Zhang, Jiadi Xu, Peter C M van Zijl, Shuixing Zhang, Guanshu Liu
Sepsis-induced acute kidney injury (SAKI) is a major complication of kidney disease associated with increased mortality and faster progression. Therefore, the development of imaging biomarkers to detect septic AKI is of great clinical interest. In this study, we aimed to characterize the endogenous chemical exchange saturation transfer (CEST) MRI contrast in the lipopolysaccharide (LPS)-induced SAKI mouse model and to investigate the use of CEST MRI for detecting such injury. We used a SAKI mouse model that was generated by i...
June 13, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29894593/contrast-induced-nephropathy-after-coronary-or-vascular-intervention-more-biomarkers-than-answers
#11
EDITORIAL
Shiva K Annamalai, Navin K Kapur
Rising urine NGAL and serum creatinine after 48 hr are potentially useful in predicting persistent creatinine increase in patients with contrast-induced AKI. Urinary NGAL may allow for early identification of a high-risk cohort following PCI. Future studies are needed to determine whether renal biomarkers are affected by clinical variables, such as heart failure acute mechanical circulatory support (AMCS) and whether they can be used to identify patients who would benefit from either AMCS reno-protection during PCI remains unknown...
June 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29884141/sex-differences-in-acute-kidney-injury-requiring-dialysis
#12
Joel Neugarten, Ladan Golestaneh, Nitin V Kolhe
BACKGROUND: Female sex has been included as a risk factor in models developed to predict the risk of acute kidney injury (AKI) associated with cardiac surgery, aminoglycoside nephrotoxicity and contrast-induced nephropathy. The commentary acompanying the Kidney Disease Improving Global Outcomes Clinical Practice Guideline for Acute Kidney Injury concludes that female sex is a shared susceptibility factor for acute kidney injury based on observations that female sex is associated with the development of hospital-acquired acute kidney injury...
June 8, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29868835/con-contrast-induced-nephropathy-should-we-try-to-avoid-contrast-media-in-patients-with-chronic-kidney-disease
#13
Michael J Ewing, John F Eidt
The incidence of acute kidney injury (AKI) attributed to iodinated contrast has been over-estimated and this has led clinicians to withhold potentially life-saving diagnostic and therapeutic interventions. There is mounting evidence that iodinated contrast plays only a minor role in the development of AKI in comparison with more significant risk factors such as pre-existing renal dysfunction, hemodynamic instability and exposure to nephrotoxic drugs. We will present data which challenge the dogma of avoiding iodinated contrast in patients with reduced renal function...
June 3, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29868731/pro-contrast-induced-nephropathy-should-we-try-to-avoid-contrast-media-in-patients-with-chronic-kidney-disease
#14
Martin Windpessl, Andreas Kronbichler
The administration of iodinated contrast medium (CM) has immediate negative impact on multiple levels of the nephron, including vasoconstriction, an increase in apoptotic pathways and oxidative stress. Therefore, contrast-induced acute kidney injury (CI-AKI) remains an important cause of sudden impairment of renal function. Far from being just a transient phenomenon, CI-AKI has consistently been shown to be associated with adverse outcomes. The phenomenon of chronic kidney disease (CKD) following AKI might explain why this entity portends a poor prognosis in the long run...
June 3, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29863496/kidney-surveillance-in-the-spotlight-contrast-induced-acute-kidney-injury-illuminated
#15
Simon J Atkinson
Acute kidney injury comprises a heterogeneous group of conditions characterized by a sudden decrease in renal function over hours to days. Contrast-induced acute kidney injury (CI-AKI) is caused by radiographic contrast agents used in diagnostic imaging. In the current issue of the JCI, Lau et al. use a mouse model of CI-AKI to study the role of resident and infiltrating phagocytes, recruited leukocytes, and tubular cells in the immune surveillance response to contrast agents. This study has the potential to provide innovative therapies for human CI-AKI...
June 4, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29863495/renal-immune-surveillance-and-dipeptidase-1-contribute-to-contrast-induced-acute-kidney-injury
#16
Arthur Lau, Hyunjae Chung, Takanori Komada, Jaye M Platnich, Christina F Sandall, Saurav Roy Choudhury, Justin Chun, Victor Naumenko, Bas Gj Surewaard, Michelle C Nelson, Annegret Ulke-Lemée, Paul L Beck, Hallgrimur Benediktsson, Anthony M Jevnikar, Sarah L Snelgrove, Michael J Hickey, Donna L Senger, Matthew T James, Justin A Macdonald, Paul Kubes, Craig N Jenne, Daniel A Muruve
Radiographic contrast agents cause acute kidney injury (AKI), yet the underlying pathogenesis is poorly understood. Nod-like receptor pyrin containing 3-deficient (Nlrp3-deficient) mice displayed reduced epithelial cell injury and inflammation in the kidney in a model of contrast-induced AKI (CI-AKI). Unexpectedly, contrast agents directly induced tubular epithelial cell death in vitro that was not dependent on Nlrp3. Rather, contrast agents activated the canonical Nlrp3 inflammasome in macrophages. Intravital microscopy revealed diatrizoate (DTA) uptake within minutes in perivascular CX3CR1+ resident phagocytes in the kidney...
June 4, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29860548/comparison-of-iohexol-and-iodixanol-induced-nephrotoxicity-mitochondrial-damage-and-mitophagy-in-a-new-contrast-induced-acute-kidney-injury-rat-model
#17
Wei Cheng, Fei Zhao, Cheng-Yuan Tang, Xu-Wei Li, Min Luo, Shao-Bin Duan
Recent progress in angiography and interventional therapy has revived interest in comparison of nephrotoxicity of low-or iso-osmolar contrast media, but detailed mechanisms and effective treatments of contrast-induced acute kidney injury (CI-AKI) remain elusive. We established a new model of CI-AKI and compared the nephrotoxicity of iohexol and iodixanol with a focus on renal oxidative stress, mitochondrial damage and mitophagy. Our results showed that 48-h dehydration plus furosemide injection before iohexol administration successfully induced CI-AKI in rats...
June 2, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29805771/optimal-hydration-volume-among-high-risk-patients-with-advanced-congestive-heart-failure-undergoing-coronary-angiography
#18
Shi-Qun Chen, Yong Liu, Wei Jie Bei, Ying Wang, Chong-Yang Duan, Deng-Xuan Wu, Kun Wang, Ping Yan Chen, Ji-Yan Chen, Ning Tan, Li-Wen Li
We investigated the relationship between weight-adjusted hydration volumes and the risk of developing contrast-induced acute kidney injury (CI-AKI) and worsening heart failure (WHF) and explored the relative safety of optimal hydration volumes in patients with advanced congestive heart failure (CHF) undergoing coronary angiography (CAG) or percutaneous coronary intervention. We included 551 patients with advanced CHF (New York Heart Association class > 2 or history of pulmonary edema) undergoing CAG (follow-up period 2...
May 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/29802583/contrast-medium-induced-acute-kidney-injury-a-narrative-review
#19
REVIEW
Valentina Pistolesi, Giuseppe Regolisti, Santo Morabito, Ilaria Gandolfini, Silvia Corrado, Giovanni Piotti, Enrico Fiaccadori
BACKGROUND AND AIMS: Contrast-induced acute kidney injury (CI-AKI) is the third leading cause of hospital-acquired acute kidney injury. It is more commonly observed following intra-arterial administration of iodinated contrast media (CM) for cardiac procedures in patients with pre-existing chronic kidney disease (CKD), and is associated with increased short- and long-term morbidity and mortality. This review investigates the key current evidence on CI-AKI definition, epidemiology and pathogenesis, as a basis for recommending preventive measures that can be implemented in clinical practice...
May 25, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29791495/early-prediction-of-contrast-induced-acute-kidney-injury-by-a-bedside-assessment-of-neutrophil-gelatinase-associated-lipocalin-during-elective-percutaneous-coronary-interventions
#20
Annunziata Nusca, Marco Miglionico, Claudio Proscia, Laura Ragni, Massimiliano Carassiti, Francesca Lassandro Pepe, Germano Di Sciascio
Contrast-induced acute kidney injury (CI-AKI) is a serious complication during percutaneous coronary interventions (PCI). Currently, the diagnosis of CI-AKI relies on serum creatinine (SCr) that is however affected by several limitations potentially leading to delayed or missed diagnoses. In this study we examined the diagnostic accuracy of a "bedside" measurement of plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) in the early detection of CI-AKI in 97 patients undergoing elective PCI. The overall incidence of CI-AKI was 3%...
2018: PloS One
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