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Preexposure prophylaxis

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https://www.readbyqxmd.com/read/28426312/safe-sex-in-the-1970s-community-practitioners-on-the-eve-of-aids
#1
Thomas R Blair
In the 1970s, groups of gay and gay-allied health professionals began to formulate guidelines for safer sexual activity, several years before HIV/AIDS. Through such organizations as the National Coalition of Gay Sexually Transmitted Disease Services, Bay Area Physicians for Human Rights, and the Sisters of Perpetual Indulgence, these practitioners developed materials that would define sexual health education for the next four decades, as well as such concepts as "bodily fluids" and the "safe sex hanky." To do so, they used their dual membership in the community and the health professions...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28418524/evaluating-testing-strategies-for-identifying-youths-with-hiv-infection-and-linking-youths-to-biomedical-and-other-prevention-services
#2
Robin Lin Miller, Cherrie B Boyer, Danielle Chiaramonte, Peter Lindeman, Kate Chutuape, Bendu Cooper-Walker, Bill G Kapogiannis, Craig M Wilson, J Dennis Fortenberry
Importance: Most human immunodeficiency virus (HIV)-infected youths are unaware of their serostatus (approximately 60%) and therefore not linked to HIV medical or prevention services. The need to identify promising and scalable approaches to promote uptake of HIV testing among youths at risk is critical. Objective: To evaluate a multisite HIV testing program designed to encourage localized HIV testing programs focused on self-identified sexual minority males and to link youths to appropriate prevention services after receipt of their test results...
April 17, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28402405/sexual-networks-dyadic-characteristics-and-hiv-acquisition-and-transmission-behaviors-among-black-men-who-have-sex-with-men-in-6-us-cities
#3
DeMarc A Hickson, Leandro A Mena, Leo Wilton, Hong-Van Tieu, Beryl A Koblin, Vanessa Cummings, Carl Latkin, Kenneth H Mayer
The role of sexual networks in the epidemiology of human immunodeficiency virus (HIV) among black men who have sex with men (MSM) is poorly understood. Using data from 1,306 black MSM in the BROTHERS Study (2009-2010) in the United States, we examined the relationships between multiple sexual dyadic characteristics and serodiscordant/serostatus-unknown condomless sex (SDCS). HIV-infected participants had higher odds of SDCS when having sex at least weekly (odds ratio (OR) = 2.41, 95% confidence interval (CI): 1...
April 10, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28392673/-life-steps-for-prep-adherence-demonstration-of-a-cbt-based-intervention-to-increase-adherence-to-preexposure-prophylaxis-prep-medication-among-sexual-minority-men-at-high-risk-for-hiv-acquisition
#4
S Wade Taylor, Christina Psaros, David W Pantalone, Jake Tinsley, Steven A Elsesser, Kenneth H Mayer, Steven A Safren
One dramatic advance in human immunodeficiency virus (HIV) prevention efforts has been the prescription of medications typically used for HIV treatment as prophylaxis against acquiring HIV. As a preventative agent, this practice is referred to as "preexposure prophylaxis" (PrEP). The U.S. Federal Drug Administration approved daily PrEP for adults at risk for HIV who do not consistently use condoms during sex with HIV-infected or unknown-status partners. In this paper, we describe a cognitive-behavioral therapy (CBT) PrEP adherence intervention developed for use in high-risk sexual-minority men in the United States, adapted from "Life-Steps," an evidence-based CBT intervention to promote adherence to HIV treatment...
February 2017: Cognitive and Behavioral Practice
https://www.readbyqxmd.com/read/28347557/hiv-prevention-and-treatment-the-evolving-role-of-the-emergency-department
#5
REVIEW
Kristi Stanley, Meredith Lora, Stephen Merjavy, Jennifer Chang, Sanjay Arora, Michael Menchine, Kathleen R Jacobson
Historically, the role of the emergency physician in HIV care has been constrained to treating sick patients with opportunistic infections and postexposure prophylaxis for occupational exposures. However, advances in HIV care have led to medications that have substantially fewer issues with toxicity and resistance, opening up an exciting new opportunity for emergency physicians to participate in treating the HIV virus itself. With this new role, it is crucial that emergency physicians be familiar with the advances in testing and medications for HIV prevention and treatment...
March 25, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28279949/usability-and-acceptability-of-a-mobile-comprehensive-hiv-prevention-app-for-men-who-have-sex-with-men-a-pilot-study
#6
Patrick S Sullivan, Robert Driggers, Joanne D Stekler, Aaron Siegler, Tamar Goldenberg, Sarah J McDougal, Jason Caucutt, Jeb Jones, Rob Stephenson
BACKGROUND: Men who have sex with men (MSM) are the group most impacted by the human immunodeficiency virus (HIV) epidemic and the only subgroup in the United States among which new HIV diagnoses are not decreasing. To achieve the US National HIV/AIDS (acquired immunodeficiency syndrome) Strategy goals of reducing new diagnoses by 25%, high (eg, 30-50%) coverage of multiple HIV prevention interventions is needed in both urban and rural areas. Mobile phone "apps" are an important channel through which prevention services could be provided at scale and at low marginal cost...
March 9, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28225453/addressing-concerns-regarding-preexposure-prophylaxis-meta-analysis
#7
Noah Kojima, Dvora Joseph Davey, Jeffrey D Klausner
No abstract text is available yet for this article.
March 13, 2017: AIDS
https://www.readbyqxmd.com/read/28225452/serious-concerns-regarding-a-meta-analysis-of-preexposure-prophylaxis-use-and-sti-acquisition
#8
Nina T Harawa, Ian W Holloway, Arleen Leibowitz, Robert Weiss, Jennifer Gildner, Raphael J Landovitz, Mario J Perez, Sonali Kulkarni, Mary Jane Rotheram-Borus, Steven Shoptaw
No abstract text is available yet for this article.
March 13, 2017: AIDS
https://www.readbyqxmd.com/read/28208119/hiv-prevention-opportunities-and-challenges
#9
REVIEW
Jeanne M Marrazzo
Preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)-based regimens has been shown to be effective in preventing acquisition of HIV infection, with protective efficacy being dependent on adherence to treatment. Data from the PROUD (Preexposure Option for Reducing HIV in the UK) and IPERGAY (Action to Prevent Risk Exposure By and For Gay Men) studies, the later of which employed event-driven PrEP, showed a high rate of protective efficacy of PrEP with TDF and emtricitabine among men who have sex with men...
December 2017: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/28146652/multidrug-resistant-hiv-1-infection-despite-preexposure-prophylaxis
#10
LETTER
David C Knox, Peter L Anderson, P Richard Harrigan, Darrell H S Tan
No abstract text is available yet for this article.
February 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28100808/correction-for-lund-et-al-hiv-1-neutralizing-iga-detected-in-genital-secretions-of-highly-hiv-1-exposed-seronegative-women-on-oral-preexposure-prophylaxis
#11
Jennifer M Lund, Kristina Broliden, Maria N Pyra, Katherine K Thomas, Deborah Donnell, Elizabeth Irungu, Timothy R Muwonge, Nelly Mugo, Madhuri Manohar, Marianne Jansson, Romel Mackelprang, Mark A Marzinke, Jared M Baeten, Jairam R Lingappa
No abstract text is available yet for this article.
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28079546/we-should-monitor-the-population-level-effects-of-preexposure-prophylaxis
#12
Chris Kenyon
No abstract text is available yet for this article.
January 28, 2017: AIDS
https://www.readbyqxmd.com/read/28060881/individual-hiv-risk-versus-population-impact-of-risk-compensation-after-hiv-preexposure-prophylaxis-initiation-among-men-who-have-sex-with-men
#13
Samuel M Jenness, Akshay Sharma, Steven M Goodreau, Eli S Rosenberg, Kevin M Weiss, Karen W Hoover, Dawn K Smith, Patrick Sullivan
OBJECTIVES: Risk compensation (RC) could reduce or offset the biological prevention benefits of HIV preexposure prophylaxis (PrEP) among those at substantial risk of infection, including men who have sex with men (MSM). We investigated the potential extent and causal mechanisms through which RC could impact HIV transmission at the population and individual levels. METHODS: Using a stochastic network-based mathematical model of HIV transmission dynamics among MSM in the United States, we simulated RC as a reduction in the probability of condom use after initiating PrEP, with heterogeneity by PrEP adherence profiles and partnership type in which RC occurred...
2017: PloS One
https://www.readbyqxmd.com/read/28059958/future-technologies-for-monitoring-hiv-drug-resistance-and-cure
#14
Urvi M Parikh, Kevin McCormick, Gert van Zyl, John W Mellors
PURPOSE OF REVIEW: Sensitive, scalable and affordable assays are critically needed for monitoring the success of interventions for preventing, treating and attempting to cure HIV infection. This review evaluates current and emerging technologies that are applicable for both surveillance of HIV drug resistance (HIVDR) and characterization of HIV reservoirs that persist despite antiretroviral therapy and are obstacles to curing HIV infection. RECENT FINDINGS: Next-generation sequencing (NGS) has the potential to be adapted into high-throughput, cost-efficient approaches for HIVDR surveillance and monitoring during continued scale-up of antiretroviral therapy and rollout of preexposure prophylaxis...
March 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28013265/decline-in-bone-mass-with-tenofovir-disoproxil-fumarate-emtricitabine-is-associated-with-hormonal-changes-in-the-absence-of-renal-impairment-when-used-by-hiv-uninfected-adolescent-boys-and-young-men-for-hiv-preexposure-prophylaxis
#15
Peter L Havens, Charles B Stephensen, Marta D Van Loan, Gertrud U Schuster, Leslie R Woodhouse, Patricia M Flynn, Catherine M Gordon, Cynthia G Pan, Brandy Rutledge, Nancy Liu, Craig M Wilson, Rohan Hazra, Sybil G Hosek, Peter L Anderson, Sharon M Seifert, Bill G Kapogiannis, Kathleen Mulligan
BACKGROUND: We aimed to define the relative importance of renal and endocrine changes in tenofovir disoproxil fumarate (TDF)-related bone toxicity. METHODS: In a study of daily TDF/emtricitabine (FTC) preexposure prophylaxis (PrEP) in human immunodeficiency virus (HIV)-uninfected young men who have sex with men, we measured changes from baseline in blood and urine markers of the parathyroid hormone (PTH)-vitamin D-fibroblast growth factor 23 (FGF23) axis, creatinine, and renal tubular reabsorption of phosphate (TRP)...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28003117/facebook-network-structure-and-awareness-of-preexposure-prophylaxis-among-young-men-who-have-sex-with-men
#16
Aditya S Khanna, Phil Schumm, John A Schneider
BACKGROUND: Young Black men who have sex with men (YBMSM) are the only population in the United States who have experienced rising human immunodeficiency virus incidence over the past decade. Consistent pre-exposure prophylaxis (PrEP) use can substantially reduce the risk of human immunodeficiency virus acquisition. What differentiates those who become aware of PrEP, and those who do not, remains largely unknown. METHODS: The social networks of YBMSM can impact their awareness of PrEP; to examine this impact, we used two waves of Facebook data from "uConnect"-a longitudinal cohort study of YBMSM in Chicago (n = 266)...
March 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/27986691/uptake-of-hiv-preexposure-prophylaxis-among-commercially-insured-persons-united-states-2010-2014
#17
Hsiu Wu, Maria C B Mendoza, Ya-Lin A Huang, Tameka Hayes, Dawn K Smith, Karen W Hoover
BACKGROUND: Daily, oral use of tenofovir disoproxil fumarate and emtricitabine (TDF-FTC) for preexposure prophylaxis (PrEP) is an effective strategy to prevent acquisition of human immunodeficiency virus (HIV) infection. It is important to monitor PrEP uptake at the national level to increase our understanding of trends in its utilization, but national HIV surveillance data do not include PrEP uptake. Our objective was to develop feasible methods to estimate PrEP uptake and to estimate uptake each year among commercially insured persons during 2010-2014...
January 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27986676/preexposure-prophylaxis-in-the-united-states-an-evolving-hiv-prevention-opportunity
#18
EDITORIAL
Ronald H Goldschmidt
No abstract text is available yet for this article.
January 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27922719/markov-mixed-effects-modeling-using-electronic-adherence-monitoring-records-identifies-influential-covariates-to-hiv-preexposure-prophylaxis
#19
Kumpal Madrasi, Ayyappa Chaturvedula, Jessica E Haberer, Mark Sale, Michael J Fossler, David Bangsberg, Jared M Baeten, Connie Celum, Craig W Hendrix
Adherence is a major factor in the effectiveness of preexposure prophylaxis (PrEP) for HIV prevention. Modeling patterns of adherence helps to identify influential covariates of different types of adherence as well as to enable clinical trial simulation so that appropriate interventions can be developed. We developed a Markov mixed-effects model to understand the covariates influencing adherence patterns to daily oral PrEP. Electronic adherence records (date and time of medication bottle cap opening) from the Partners PrEP ancillary adherence study with a total of 1147 subjects were used...
December 6, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27919092/correction-tenofovir-and-emtricitabine-tenofovir-preexposure-prophylaxis-for-herpes-simplex-virus-type-2
#20
(no author information available yet)
No abstract text is available yet for this article.
December 6, 2016: Annals of Internal Medicine
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