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Preexposure prophylaxis

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https://www.readbyqxmd.com/read/29324178/sex-venue-based-network-analysis-to-identify-hiv-prevention-dissemination-targets-for-men-who-have-sex-with-men
#1
Rupa R Patel, Douglas A Luke, Enola K Proctor, William G Powderly, Philip A Chan, Kenneth H Mayer, Laura C Harrison, Amar Dhand
PURPOSE: The aim of this study was to identify sex venue-based networks among men who have sex with men (MSM) to inform HIV preexposure prophylaxis (PrEP) dissemination efforts. METHODS: Using a cross-sectional design, we interviewed MSM about the venues where their recent sexual partners were found. Venues were organized into network matrices grouped by condom use and race. We examined network structure, central venues, and network subgroups. RESULTS: Among 49 participants, the median age was 27 years, 49% were Black and 86% reported condomless anal sex (ncAS)...
January 2018: LGBT Health
https://www.readbyqxmd.com/read/29323558/optimizing-delivery-of-hiv-preexposure-prophylaxis-for-women-in-the-united-states
#2
Erika Aaron, Cori Blum, Dominika Seidman, Mary Jo Hoyt, Joanne Simone, Meg Sullivan, Dawn K Smith
Preexposure prophylaxis (PrEP) is a highly effective HIV prevention method; however, it is underutilized among women who are at risk for acquisition of HIV. Women comprise one in five HIV diagnoses in the United States, and significant racial disparities in new HIV diagnoses persist. The rate of new HIV diagnoses among black and African American women in 2015 was 16 times greater than that of white women. These disparities highlight the importance of HIV prevention strategies for women, including the use of PrEP...
January 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29278542/potential-kidney-toxicity-from-the-antiviral-drug-tenofovir-new-indications-new-formulations-and-a-new-prodrug
#3
Lili Chan, Benjamin Asriel, Ellen F Eaton, Christina M Wyatt
PURPOSE OF REVIEW: The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (TDF) is also a component of daily preexposure prophylaxis (PrEP) to reduce the risk of HIV infection in high-risk populations. Although TDF is well tolerated, the potential for kidney and bone toxicity has important implications for public health given the large number of individuals exposed to TDF worldwide...
December 22, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29274655/do-you-prep-a-review-of-primary-care-provider-knowledge-of-prep-and-attitudes-on-prescribing-prep
#4
Leah Turner, Abbey Roepke, Emily Wardell, Anne M Teitelman
Oral preexposure prophylaxis (PrEP) has been proven to be a safe and effective means of preventing HIV. The purpose of our literature review was to examine primary care provider knowledge and attitudes about prescribing PrEP. PubMed, CINAHL, Web of Science, and Scopus were searched and additional articles were identified through other sources, yielding 11 articles that met inclusion criteria. Overall, there was high variability among providers regarding attitudes, knowledge, and prescriptive practices related to PrEP...
January 2018: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29210777/costs-and-benefits-of-on-demand-hiv-preexposure-prophylaxis-in-msm
#5
Isabelle Durand-Zaleski, Pierre Mutuon, Isabelle Charreau, Cecile Tremblay, Daniela Rojas, Gilles Pialoux, Christian Chidiac, Catherine Capitant, Bruno Spire, Laurent Cotte, Julie Chas, Laurence Meyer, Jean Michel Molina
OBJECTIVES: We undertook the economic evaluation of the double-blind randomized ANRS-IPERGAY trial, which showed the efficacy of on-demand preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)-emtricitabine (FTC) in preventing HIV infection among high-risk MSM. DESIGN AND METHODS: The economic evaluation was prospective. Counseling, drugs (TDF-FTC at &OV0556;500.88 for 30 tablets), tests, visits, and hospital admissions were valued based on in-trial use...
January 2, 2018: AIDS
https://www.readbyqxmd.com/read/29166777/tenofovir-disoproxil-fumarate-emtricitabine-fits-for-all-as-appropriate-hiv-1-pre-exposure-prophylaxis
#6
Lucia Taramasso, Niccolò Riccardi, Filippo Del Puente, Bianca Bruzzone, Diego Ripamonti, Beatrice D'Ambrosio, Claudio Viscoli, Antonio Di Biagio
Pre-exposure prophylaxis (PrEP) with TDF/FTC significantly reduces the risk for HIV-1 transmission, but, to date, nobody knows if PrEP can still be useful in case of viruses harboring resistances to TDF/FTC or if alternative antiretroviral drugs might be rather proposed in selected cases. We promote the debate by describing a case of an acute infection with multiresistant HIV that occurred in a young girl who started a relationship with an HIV-infected partner who had a known multiresistant HIV.
January 18, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29145597/laboratory-testing-of-a-cohort-of-commercially-insured-users-of-hiv-preexposure-prophylaxis-in-the-united-states-2011-2015
#7
Ya-Lin A Huang, Guoyu Tao, Taraz Samandari, Karen W Hoover
To ensure the health and safety of persons taking antiretroviral medication for HIV preexposure prophylaxis (PrEP), CDC guidelines recommend initial and follow-up laboratory testing. We assessed the rates of recommended testing using a commercial insurance claims database. Before taking PrEP, 45% of users were tested for HIV, 31% for creatinine, 55% for syphilis, 43% for chlamydia/gonorrhea, and 38% for hepatitis B. By 6 months after PrEP initiation, 38% were tested for HIV, 37% for creatinine, 49% for syphilis, and 39% for chlamydia/gonorrhea...
November 14, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29116842/what-can-we-do-or-change-to-encourage-people-to-seek-out-preexposure-prophylaxis
#8
Lisa A Eaton
No abstract text is available yet for this article.
December 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29076941/newly-acquired-infection-with-multidrug-resistant-hiv-1-in-a-patient-adherent-to-preexposure-prophylaxis
#9
Martin Markowitz, Howard Grossman, Peter L Anderson, Robert Grant, Monica Gandhi, Howard Horng, Hiroshi Mohri
No abstract text is available yet for this article.
December 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29071519/preexposure-prophylaxis-of-hiv-infection-the-role-of-clinical-practices-in-ending-the-hiv-epidemic
#10
REVIEW
Iryna B Zablotska, Catherine C O'Connor
PURPOSE OF REVIEW: The aim of this study is to summarise the recent evidence from high-income settings about providers' ability to deliver on the UNAIDS goal of at least three million people at substantial risk of HIV infection with PrEP by 2020, including awareness and knowledge about PrEP, willingness to prescribe PrEP, current levels of prescribing and service delivery models and issues. RECENT FINDINGS: Awareness about PrEP among health providers is growing, but at different pace depending on provider type...
December 2017: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29059077/the-microbiome-and-hiv-prevention-strategies-in-women
#11
Salim S Abdool Karim, Jo-Ann S Passmore, Cheryl Baxter
PURPOSE OF REVIEW: HIV prevention approaches that women can use and control are a priority. Results from topical and oral preexposure prophylaxis (PrEP) HIV prevention trials have produced inconsistent results in women. One of the main behavioural factors impacting effectiveness of PrEP has been suboptimal adherence. In this review, we examine biological factors that modulate topical PrEP efficacy, with particular focus on the vaginal microbiome. RECENT FINDINGS: Genital inflammation is an independent risk factor for HIV acquisition in women...
October 20, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29048955/integrating-hiv-preexposure-prophylaxis-prep-into-routine-preventive-health-care-to-avoid-exacerbating-disparities
#12
Sarah K Calabrese, Douglas S Krakower, Kenneth H Mayer
More than 3 decades since its emergence in the United States, HIV continues to spread and disproportionately affect socially marginalized groups. Preexposure prophylaxis (PrEP), a highly effective prevention strategy federally approved since 2012, could fundamentally alter the course of the epidemic. However, PrEP's potential has not been fully realized, in part because health care providers have been slow to adopt PrEP in clinical practice and have been selective in their discussion of PrEP with patients. This nonstandardized approach has constrained PrEP access...
December 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29020235/redefining-human-immunodeficiency-virus-hiv-preexposure-prophylaxis-failures
#13
Julia L Marcus, Leo B Hurley, Dong Phuong Nguyen, Michael J Silverberg, Jonathan E Volk
No abstract text is available yet for this article.
October 30, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020194/comparison-of-measures-of-adherence-to-hiv-preexposure-prophylaxis-among-adolescent-and-young-men-who-have-sex-with-men-in-the-united-states
#14
Catherine A Koss, Sybil G Hosek, Peter Bacchetti, Peter L Anderson, Albert Y Liu, Howard Horng, Leslie Z Benet, Karen Kuncze, Alexander Louie, Parya Saberi, Craig M Wilson, Monica Gandhi
Background: Young men who have sex with men (MSM) are disproportionately impacted by HIV. Preexposure prophylaxis (PrEP) could reduce HIV acquisition among youth, but sub-optimal adherence threatens effectiveness. Optimal metrics of PrEP adherence among adolescents have not been defined. Methods: The ATN 110 and 113 studies provided daily oral PrEP with tenofovir (TFV) disoproxil fumarate/emtricitabine over 48 weeks to a diverse population of MSM (15-22 years). Self-reported adherence was assessed and PrEP drug concentrations measured from hair and dried blood spot (DBS) samples; 23% of participants received Wisepill electronic monitoring devices...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28991887/changes-in-kidney-function-associated-with-daily-tenofovir-disoproxil-fumarate-emtricitabine-for-hiv-preexposure-prophylaxis-use-in-the-united-states-demonstration-project
#15
Eric C Tang, Eric Vittinghoff, Peter L Anderson, Stephanie E Cohen, Susanne Doblecki-Lewis, Oliver Bacon, Megan E Coleman, Wairimu Chege, Susan P Buchbinder, Michael A Kolber, Richard Elion, Michael Shlipak, Albert Y Liu
BACKGROUND: HIV preexposure prophylaxis (PrEP) using daily oral tenofovir-disoproxil-fumarate/emtricitabine (TDF/FTC) is effective for preventing HIV acquisition, but concerns remain about its potential kidney toxicity. This study examined kidney function in individuals using PrEP in real-world clinical settings. SETTING: Demonstration project in two sexually transmitted infection clinics and a community health center. METHODS: We evaluated kidney function among men who have sex with men and transgender women taking TDF/FTC PrEP for up to 48 weeks...
October 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28910270/updated-dosing-instructions-for-immune-globulin-human-gamastan-s-d-for-hepatitis-a-virus-prophylaxis
#16
Noele P Nelson
GamaSTAN S/D (Grifols Therapeutics, Inc., Research Triangle Park, North Carolina) is a sterile, preservative-free solution of immune globulin (IG) for intramuscular administration and is used for prophylaxis against disease caused by infection with hepatitis A, measles, varicella, and rubella viruses (1). GamaSTAN S/D is the only IG product approved by the Food and Drug Administration for hepatitis A virus (HAV) prophylaxis. In July 2017, GamaSTAN S/D prescribing information was updated with changes to the dosing instructions for hepatitis A preexposure and postexposure prophylaxis indications...
September 15, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28906283/preexposure-prophylaxis-a-cautionary-tale
#17
Aimee A Desrosiers, Afsoon D Roberts, Gary L Simon
No abstract text is available yet for this article.
September 24, 2017: AIDS
https://www.readbyqxmd.com/read/28902677/disparities-in-awareness-of-hiv-postexposure-and-preexposure-prophylaxis-among-notified-partners-of-hiv-positive-individuals-new-york-city-2015-2017
#18
Kavita Misra, Chi-Chi Udeagu
BACKGROUND: Named sex- or needle-sharing partners of HIV-positive individuals are a priority prevention population due to their known HIV exposure. Understanding postexposure and preexposure prophylaxis (PEP and PrEP) awareness and use among them is important for successful interventions. METHODS: Data from notified partners of HIV-positive individuals (New York City, May 2015-April 2017) were analyzed to describe PEP/PrEP awareness, provider discussion, and use by sociodemographic and risk characteristics...
October 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902562/preexposure-prophylaxis-adapting-hiv-prevention-models-to-achieve-worldwide-access
#19
Stewart Landers, Farzana Kapadia
No abstract text is available yet for this article.
October 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28902545/the-complex-road-ahead-for-preexposure-prophylaxis-a-primary-care-physician-perspective
#20
Richard E Greene
No abstract text is available yet for this article.
October 2017: American Journal of Public Health
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