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R Colomer, I Aranda-López, J Albanell, T García-Caballero, E Ciruelos, M Á López-García, J Cortés, F Rojo, M Martín, J Palacios-Calvo
On page 5 of the article, in the last paragraph of the section "Prognostic genetic platforms: molecular phenotypes and translation to the clinic" a relevant discrepancy between the text and Table 1 could be misunderstood, therefore the paragraph was corrected.
June 18, 2018: Clinical & Translational Oncology
L de la Cruz-Merino, N Palazón-Carrión, F Henao-Carrasco, E Nogales-Fernández, M Álamo-de la Gala, A Vallejo-Benítez, M Chiesa, V Sánchez-Margalet
Immunology and immunotherapy of cancer is an expanding field in oncology, with recent great achievements obtained through the new successful approaches implemented to circumvent immune evasion, which is undoubtedly considered a novel hallmark of cancer. Translational research in this topic has revealed targets that can be modulated in the clinical setting with new compounds and strategies. Like most of the tumors, breast cancer is considered a complex and heterogeneous disease in which host immune responses have been also recently demonstrated of critical relevance...
June 18, 2018: Clinical & Translational Oncology
Jose María Mostaza, Manuel Jesús Romero Jiménez, Fernando José Ruiz Laiglesia, José Antonio Díaz Peromingo, Manuel Beltrán Robles, Ernesto Guevara Sierra, Ana Santander Bilbao, Carmen Suárez
Background: Available data regarding clinical profile and management of elderly patients with atrial fibrillation (AF) according to dependency, fragility and cognitive impairment are scarce. The objective of the study was to analyze the biodemographic data, clinical profile and antithrombotic treatment according to dependency, fragility and cognitive impairment in elderly AF patients. Methods: Cross-sectional and multi-center study performed in consecutive AF patients ≥ 75 years treated with oral anticoagulants ≥ 3 months attended in Internal Medicine Departments in Spain...
April 2018: Journal of Geriatric Cardiology: JGC
Antonio Román, Andrea Flumini, Julio Santiago
The mental representation of both time and number shows lateral spatial biases, which can be affected by habitual reading and writing direction. However, this effect is in place before children begin to read. One potential early cause is the experiences of looking at picture books together with a carer, as those images also follow the directionality of the script. What is the underlying mechanism for this effect? In the present study, we test the possibility that such experiences induce spatial biases in mental model construction, a mechanism which is a good candidate to induce the biases observed with numbers and times...
August 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Manuel Gorostidi, Mercedes Sánchez-Martínez, Luis M Ruilope, Auxiliadora Graciani, Juan J de la Cruz, Rafael Santamaría, María D Del Pino, Pilar Guallar-Castillón, Fernando de Álvaro, Fernando Rodríguez-Artalejo, José R Banegas
BACKGROUND: Chronic kidney disease (CKD) is a public health problem worldwide. We aimed to estimate the CKD prevalence in Spain and to examine the impact of the accumulation of cardiovascular risk factors (CVRF). MATERIAL AND METHODS: We performed a nationwide, population-based survey evaluating 11,505 individuals representative of the Spanish adult population. Information was collected through standardised questionnaires, physical examination, and analysis of blood and urine samples in a central laboratory...
June 15, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
L G Nelissen, I J N Koppen, F R Follett, C Boggio-Marzet, M Saps, K Garzon, M A Benninga
INTRODUCTION AND AIMS: The prevalence of functional gastrointestinal disorders (FGIDs) in Argentinean children and adolescents has not yet been studied. Our aim was to determine the prevalence of FGIDs among children and adolescents in Argentina using the Rome III diagnostic criteria. MATERIALS AND METHODS: A total of 483 children, 12-18 years of age, from 3 private schools and 3 public schools, were included in the study. Each child completed the Spanish version of the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III), which is an age-appropriate and previously validated instrument for diagnosing FGIDs according to the Rome III criteria...
June 15, 2018: Revista de Gastroenterología de México
Iñigo Galilea-Zabalza, Pilar Buil-Cosiales, Jordi Salas-Salvadó, Estefanía Toledo, Carolina Ortega-Azorín, Javier Díez-Espino, Zenaida Vázquez-Ruiz, María Dolores Zomeño, Jesús Vioque, José Alfredo Martínez, Dora Romaguera, Napoleón Perez-Farinos, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Fernando Arós, Josep Antoni Tur, Francisco Tinahones, Lluis Serra-Majem, Alba Marcos-Delgado, Manuel Ortega-Calvo, Clotilde Vázquez, Xavier Pintó, Josep Vidal, Lidia Daimiel, Miguel Delgado-Rodríguez, Pilar Matía, Dolores Corella, Andrés Diaz-López, Nancy Babio, Miguel Angel Muñoz, Montse Fitó, Sandra González-Palacios, Itziar Abete, Antonio García-Rios, Emilio Ros, Miguel Ángel Martínez-González
We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring the metabolic syndrome. We analyzed baseline data from 6430 men and women (age 55-70 years) participating in the PREDIMED-Plus study. PREDIMED-Plus is a multi-centre randomized trial testing an energy-restricted MedDiet combined with promotion of physical activity and behavioral therapy for primary cardiovascular prevention compared to a MedDiet alone...
2018: PloS One
Virginia Velasco-Tirado, Montserrat Alonso-Sardón, Adriana Cosano-Quero, Ángela Romero-Alegría, Leire Sánchez-Los Arcos, Amparo López-Bernus, Javier Pardo-Lledías, Moncef Belhassen-García
BACKGROUND: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are serious mucocutaneous reactions. In Spain, the epidemiology and resulting expenses of these diseases are not well established. METHODOLOGY: Retrospective descriptive study using the Minimum Basic Data Set (CMBD in Spanish) in patients admitted to hospitals of the National Health System between 2010 and 2015 with a diagnosis of SJS and TEN (combination of ICD-9 codes 695.13, 695.14, and 695...
2018: PloS One
Becky Marquez, Greg Norman, James Fowler, Kim Gans, Bess Marcus
OBJECTIVE: Despite data linking the social environment to physical inactivity in Latinas, research on social network predictors of physical activity (PA) is limited. This study examined social network predictors of PA change in Latinas. METHODS: Egocentric network data were collected from 102 adult Latinas (egos) participating in a randomized controlled PA intervention trial for underactive women. Moderate-to-vigorous PA (MVPA) was measured in minutes per week using the 7-Day PA Recall Interview and accelerometers at baseline and 12 months...
2018: PloS One
Raquel Pérez-Carro, Fiona Blanco-Kelly, Lilián Galbis-Martínez, Gema García-García, Elena Aller, Blanca García-Sandoval, Pablo Mínguez, Marta Corton, Ignacio Mahíllo-Fernández, Inmaculada Martín-Mérida, Almudena Avila-Fernández, José M Millán, Carmen Ayuso
INTRODUCTION: Mutations in USH2A cause both isolated Retinitis Pigmentosa (RP) and Usher syndrome (that implies RP and hearing impairment). One of the most frequent variants identified in this gene and among these patients is the p.(Cys759Phe) change. However, the pathogenic role of this allele has been questioned since it was found in homozygosity in two healthy siblings of a Spanish family. To assess the causative role of USH2A p.(Cys759Phe) in autosomal recessive RP (ARRP) and Usher syndrome type II (USH2) and to establish possible genotype-phenotype correlations associated with p...
2018: PloS One
Kirk Geale, María Álvarez, Maria Polyzoi, Xavier Màlaga, Cristina Pineda, César Hernández
OBJECTIVE: Estimate the budget impact (BI) of introducing local autograft (LA) combined with demineralized bone matrix (LA+DBM) in lumbar spinal fusion (LSF) procedures to treat lumbar degenerative disc disease (LDDD) in Spain. METHODS: A decision tree model was developed to evaluate the 4-year BI associated with introducing LA+DBM putty to replace currently available grafting methods including iliac crest bone graft (ICBG), LA alone, and LA combined with beta-tricalcium phosphate (LA+ceramics), with 30%, 40%, and 30% market shares, respectively...
June 18, 2018: Journal of Medical Economics
Lene Symes, Judith McFarlane, John Maddoux, Lisa Beth Levine, Kimberly S Landrum, Cari Delgado McFarlane
There is a particular need for valid scales to screen for posttraumatic stress disorder (PTSD) among women who seek safe shelter from intimate partner violence. Screening to identify women who are at risk for PTSD can lead to early intervention that reduces the risk for PTSD-related outcomes such as poor decision making, inconsistent parenting, and behavior dysfunction among their children. The gold standard for diagnosing PTSD is the Clinician-Administered PTSD Scale for Diagnostic and Statistical Manual of Mental Disorders (5th ed...
June 1, 2018: Journal of Interpersonal Violence
Luis Eduardo Garrido, Juan Ramón Barrada, José Armando Aguasvivas, Agustín Martínez-Molina, Víctor B Arias, Hudson F Golino, Eva Legaz, Gloria Ferrís, Luis Rojo-Moreno
During the present decade a large body of research has employed confirmatory factor analysis (CFA) to evaluate the factor structure of the Strengths and Difficulties Questionnaire (SDQ) across multiple languages and cultures. However, because CFA can produce strongly biased estimations when the population cross-loadings differ meaningfully from zero, it may not be the most appropriate framework to model the SDQ responses. With this in mind, the current study sought to assess the factorial structure of the SDQ using the more flexible exploratory structural equation modeling approach...
June 1, 2018: Assessment
Alba Camacho-Cardenosa, Marta Camacho-Cardenosa, Adrián González-Custodio, Ismael Martínez-Guardado, Rafael Timón, Guillermo Olcina, Javier Brazo-Sayavera
BACKGROUND: The relative age effect is essential throughout all of the talent selection processes in sports, especially during adolescence, which leaves fewer athletes within each cohort that are born late in the selected year. The aim of the present study was to examine the role of relative age in anthropometric and physical performance characteristics of youth handball players by gender. METHODS: The sample that was selected included 47 participants (male n = 23, female n = 24)...
May 23, 2018: Sports
Mario Sánchez-García, Javier Sánchez-Sánchez, Alejandro Rodríguez-Fernández, David Solano, Daniel Castillo
The aim of this study was to analyze the association between sprint ability and endurance capacity in soccer referees. Twenty-three Spanish officials participated in this study. Each referee undertook, in this order, a 40 m linear straight sprinting test (40 m Sprint) and the Yo⁻Yo intermittent recovery level 1 test (YYIR1) interspersed with a 8 min of self-administered rest. The results in the 40 m Sprint test showed that the time spent by referees was 5.56 ± 0.27 s and achieved a maximum velocity of 31...
March 30, 2018: Sports
José Joaquín Mira, Irene Carrillo, Carmen Silvestre, Pastora Pérez-Pérez, Cristina Nebot, Guadalupe Olivera, Javier González de Dios, Jesús María Aranaz Andrés
OBJECTIVES: Identify the sources of overuse from the point of view of the Spanish primary care professionals, and analyse the frequency of overuse due to pressure from patients in addition to the responses when professionals face these demands. DESIGN: A cross-sectional study. SETTING: Primary care in Spain. PARTICIPANTS: A non-randomised sample of 2201 providers (general practitioners, paediatricians and nurses) was recruited during the survey...
June 15, 2018: BMJ Open
K Satué, M Marcilla, P Medica, C Cravana, E Fazio
Growth hormone (GH) and insulin-like growth factor (IGF-I) exert essential functions to maintain an adequate metabolic activity for correct placental and fetal development. Although fructosamine (FRUCT) is used in clinical evaluation to assess the glycaemic state, the relationships between GH, IGF-I and FRUCT remain unknown in the mare. Therefore, the objectives of this study were to evaluate the relationships among these parameters in pregnant mares. A total of 30 healthy Spanish Purebred mares, with an age range of 9...
May 30, 2018: Theriogenology
Ana R Sepúlveda, Santos Solano, Miriam Blanco, Tatiana Lacruz, Montserrat Graell
The aim was to examine the prevalence of childhood mental disorders in overweight/obese pediatric sample and also to explore the relationship between these pathologies and loss of control eating (LOC). Another aim was to assess the association between psychopathology and severity of obesity. A total of 170 children from different Health Centers were evaluated (84 girls and 86 boys; aged 8 to 12 years). Childhood psychological problems were assessed through a standardized diagnostic interview schedule (K-SADS-R) and by questionnaires (STAIC for anxiety, CDI for depression and ChEAT for disordered eating)...
June 8, 2018: Psychiatry Research
C C Torres-Contreras, A N Páez-Esteban, A Hinestrosa-Díaz Del Castillo, M K Rincón-Romero, A Amaris-Vega, J P Martínez-Patiño
OBJECTIVE: To determine the incidence and the factors associated with delirium in intensive care unit patients. METHODS: A cohort study conducted on 134 patients in the intensive care unit at a clinic in Bucaramanga, Colombia., who were recruited in the first 24hours following admission and on whom the Richmond Agitation-Sedation Scale (RASS), PRE-DELIRIC version in Spanish, and Confusion Assessment method for Intensive Care Unit (CAM-ICU) were applied; the outcome was evaluated through daily monitoring with CAM-ICU...
June 13, 2018: Enfermería Intensiva
Frank J Penedo, Michael H Antoni, Patricia I Moreno, Lara Traeger, Dolores Perdomo, Jason Dahn, Gregory E Miller, Steve Cole, Julian Orjuela, Edgar Pizarro, Betina Yanez
Almost 2.8 million men in the U.S. are living with prostate cancer (PC), accounting for 40% of all male cancer survivors. Men diagnosed with prostate cancer may experience chronic and debilitating treatment side effects, including sexual and urinary dysfunction, pain and fatigue. Side effects can be stressful and can also lead to poor psychosocial functioning. Prior trials reveal that group-based cognitive behavioral stress and self-management (CBSM) is effective in reducing stress and mitigating some of these symptoms, yet little is known about the effects of culturally-translated CBSM among Spanish-speaking men with PC...
June 14, 2018: Contemporary Clinical Trials
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