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Dose reference levels

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https://www.readbyqxmd.com/read/29351655/establishing-diagnostic-reference-levels-for-cardiac-computed-tomography-angiography-in-saudi-arabia
#1
Ali B Alhailiy, Peter L Kench, Mark F McEntee, Patrick C Brennan, Elaine A Ryan
Cardiac computed tomography angiography (CCTA) is a commonly used diagnostic imaging tool for cardiovascular disease. Despite constant improvements to imaging technologies, the radiation dose to patients remains a concern when using this procedure. Diagnostic reference levels (DRLs) are used as a trigger to identify and alert individual facilities that are using high doses during CT. This study aims to assess patient radiation dose and establish new national DRLs (NDRL) associated with CCTA in Saudi clinical practices...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29351095/the-effect-of-ketorolac-on-thoracolumbar-posterolateral-fusion-a-systematic-review-and-meta-analysis
#2
Jesse Li, Remi M Ajiboye, Michael H Orden, Akshay Sharma, Austin Drysch, Sina Pourtaheri
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: The purpose of this study was to evaluate the effect of postoperative ketorolac administration (ie, dosage and duration of use) on pseudarthrosis following thoracolumbar posterolateral spinal fusions. SUMMARY OF BACKGROUND DATA: Ketorolac is a nonsteroidal anti-inflammatory drug often administered for pain control after spine surgery. The main concern with ketorolac is the risk of pseudarthrosis following fusion...
January 18, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29350490/chronic-exposure-to-high-doses-of-selenium-in-the-first-trimester-of-pregnancy-case-report-and-brief-literature-review
#3
Luisa D'Oria, Massimo Apicella, Carmen De Luca, Angelo Licameli, Caterina Neri, Marcella Pellegrino, Daniela Simeone, Marco De Santis
BACKGROUND: Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE: A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestational week (g.w.) 7 to 12, due to a prescription error. The patient experienced nausea, vomiting, hand and foot paresthesia, followed by fatigue, loss of fingernails and hair...
January 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29349404/external-jugular-vein-thrombosis-secondary-to-deep-tissue-neck%C3%A2-massage
#4
Sneha Raju, John Byrne
An 85-year-old man presented with an acute asymptomatic lateral neck mass in the context of deep tissue neck massages during the past year. He was referred to vascular surgery after an ultrasound examination of the neck revealed a thrombus in the external jugular vein. His past medical history and comorbidities were noncontributory. A multidisciplinary team of vascular surgeons and hematologists did not recommend any anticoagulation, given that the patient did not have any risk factors for thrombosis as well as normal D-dimer levels...
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29344826/phytochemical-analysis-and-evaluation-of-the-antioxidant-anti-inflammatory-and-antinociceptive-potential-of-phlorotannin-rich-fractions-from-three-mediterranean-brown-seaweeds
#5
Amal Abdelhamid, Meriem Jouini, Haifa Bel Haj Amor, Zeineb Mzoughi, Mehdi Dridi, Rafik Ben Said, Abderrahman Bouraoui
Phlorotannins, phenolic compounds produced exclusively by seaweeds, have been reported to possess various pharmacological properties. However, there have been few works on these compounds from Mediterranean seaweeds. In this study, we investigated the phytochemical analysis and pharmacological potential of phlorotannin-rich fractions from three brown seaweeds collected along the Tunisia coast: Cystoseira sedoides (PHT-SED), Cladostephus spongeosis (PHT-CLAD), and Padina pavonica (PHT-PAD). Phytochemical determinations showed considerable differences in total phenolic content (TPC) and phlorotannin content (PHT)...
January 18, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29344685/long-term-safety-and-efficacy-of-botulinum-toxin-a-treatment-in-adolescent-patients-with-axillary-bromhidrosis
#6
Tao Wang, Jiasheng Dong, Jinguang He
BACKGROUND: For adolescent bromhidrosis, the long-term safety and efficacy of botulinum toxin type A (BTX-A) treatment are not clear to date. PATIENTS AND METHODS: From June 2011 to July 2016, 62 adolescent patients with primary axillary bromhidrosis were recruited and 50 U of BTX-A was administered in each axilla. Repetitive injections were performed when the malodor returned. RESULTS: The average follow-up was 2.64 years. There were no reported local or systemic adverse effects...
January 17, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29342291/portuguese-study-of-mean-glandular-dose-in-mammography-and-comparison-with-european-references
#7
Cláudia Sá Dos Reis, Mário João Fartaria, João H Garcia Alves, Ana Pascoal
To characterise the mean glandular dose (MGD) in a sample of healthcare providers for digital mammography in Portugal. To compare the achieved values with European references. The MGD was measured on a poly-methyl-methacrylate phantom (45 mm) for each system using dosimeters. In addition, MGD was estimated using exposure settings collected from mammography exams in clinical context. Data were collected from 25 computed-radiography systems (CR) and 13 integrated digital (DR). For both measurements (phantom and clinical exposures), the average MGD for CR was higher compared to the DR...
January 12, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29342278/dosimetry-of-adult-and-pediatric-patients-for-common-digital-radiography-examinations
#8
Bhupendra Singh Rana, Sanjeev Kumar, Inderjeet Singh Sandhu, Narinder Paul Singh
The present work reports dosimetry data on adult and pediatric patients for some common radiographic examinations during the standard hospital routine. The measurements are the part of quality assurance program to determine radiation exposures to patients in these examinations. The entrance skin doses (ESDs) of the patients were measured from 2451 projection for 12 diagnostic examinations in digital radiography (DR). The ESDs in adult patient were measured using thermoluminescence dosemeters placed on the skin of the patient...
January 12, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29341984/effect-of-age-at-vaccination-on-rotavirus-vaccine-effectiveness-in-bolivian-infants
#9
Rachel M Burke, Jacqueline E Tate, Kimberly D Pringle, Manish Patel, Lucia H De Oliveira, Umesh D Parashar
BACKGROUND: Rotavirus vaccines are less effective in developing countries versus developed countries. One hypothesis for this difference in performance is that higher levels of maternal antibodies in developing countries may interfere with vaccine response, suggesting that delayed dosing could be beneficial. The present analysis aims to assess whether rotavirus vaccine effectiveness (VE) varies by age at vaccination during routine use in Bolivia. METHODS: Data were merged from two post-licensure evaluations of monovalent rotavirus vaccine (RV1) in Bolivia, where two doses of RV1 are recommended at two and four months of age...
January 16, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29339046/stereotactic-body-radiation-therapy-sbrt-for-high-risk-prostate-cancer-where-are-we-now
#10
REVIEW
Alejandro Gonzalez-Motta, Mack Roach
PURPOSE: Stereotactic body radiation therapy (SBRT) is increasingly being used for the management of localized prostate cancer. This trend combined with declining use of brachytherapy (BT) has pushed issues and questions regarding the use of SBRT to the forefront. A systematic literature review was conducted to review the current evidence of biochemical disease-free survival (bDFS) and toxicity of SBRT in high-risk (HR) prostate cancer. METHODS AND MATERIALS: A search was carried out on the PubMed and Embase databases...
December 2, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29334651/effects-of-perinatal-fluoride-exposure-on-the-expressions-of-mir-124-and-mir-132-in-hippocampus-of-mouse-pups
#11
Jixiang Wang, Yuliang Zhang, Zhenzhen Guo, Rui Li, Xingchen Xue, Zilong Sun, Ruiyan Niu
To investigate the effects of perinatal fluoride exposure on learning and memory ability of mouse offspring, ICR female mice were received different doses of sodium fluoride (0, 25, 50, 100 mg/L NaF) from pregnant day 7 to lactational day 21. Pups were exposed to fluoride through the cord blood and breast milk. Open field test showed that compared to the control group, perinatal fluoride exposure significantly decreased the number of entries into the center zone in 100 mg/L NaF group. In the eight-arm maze test, the number of working memory errors, reference memory errors, and the total arm entries were significantly increased in fluoride treatment groups, compared to the control group...
January 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29331603/metabolic-risk-factors-in-schizophrenia-and-bipolar-disorder-the-effect-of-comedication-with-selective-serotonin-reuptake-inhibitors-and-antipsychotics
#12
K K Fjukstad, A Engum, S Lydersen, I Dieset, N Eiel Steen, O A Andreassen, O Spigset
BACKGROUND: The aim of this observational study was to investigate the relationship between metabolic factors and use of selective serotonin reuptake inhibitors (SSRIs) combined with olanzapine, quetiapine or risperidone. METHODS: Data from the Norwegian Thematically Organized Psychosis study, a cross-sectional study on 1301 patients with schizophrenia (n=868) or bipolar disorder (n=433), were analyzed. As exposure variables in the linear regression model were included the dose or serum concentration of SSRIs (n=280) and of olanzapine (n=398), quetiapine (n=234) or risperidone (n=128)...
April 17, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29323552/using-the-american-college-of-radiology-dose-index-registry-to-evaluate-practice-patterns-and-radiation-dose-estimates-of-pediatric-body-ct
#13
Benjamin Wildman-Tobriner, Keith J Strauss, Mythreyi Bhargavan-Chatfield, Nadja Kadom, Peter Vock, Kimberly E Applegate, Donald P Frush
OBJECTIVE: Imaging registries afford opportunities to study large, heterogeneous populations. The purpose of this study was to examine the American College of Radiology CT Dose Index Registry (DIR) for dose-related demographics and metrics of common pediatric body CT examinations. MATERIALS AND METHODS: Single-phase CT examinations of the abdomen and pelvis and chest submitted to the DIR over a 5-year period (July 2011-June 2016) were evaluated (head CT frequency was also collected)...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29315767/benchmark-dose-analysis-framework-for-developing-wildlife-toxicity-reference-values
#14
David B Mayfield, Daniel G Skall
The effects characterization phase of ecological risk assessments often includes the selection or development of toxicity reference values (TRVs) for chemicals under investigation. In wildlife risk assessments, TRVs are thresholds represented by a dose or concentration associated with a specified adverse response. Traditionally, a TRV may be derived from an estimate of the no- or lowest adverse effect level (NOAEL or LOAEL), identified from a controlled toxicity study. Due to the limitations in this approach, risk assessors are increasingly developing TRVs using alternative methods...
January 9, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29315415/local-levels-of-patient-radiation-exposure-in-a-urology-operating-room-in-italy
#15
C Giordano, G Marcello, L Barbattini, R Gobbi
The data analysed came from 545 patients and were related to five types of procedures performed in the urology operating room: percutaneous nephrolithotomy (PCNL), retrograde intrarenal surgery (RIRS), ureteropyeloscopy (UPS), ureteral catheterisation and nephrostomy. Local reference levels (75th percentiles) were determined for the various procedures. The peak entrance skin dose for a patient 20 cm thick was highest for PCNL, being 82 mGy, followed by 43 mGy for nephrostomy, 23 mGy for RIRS, 23 mGy for UPS and 17 mGy for stenting...
January 5, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29304461/legacy-and-emerging-organophosph%C3%AE-rus-flame-retardants-in-car-dust-from-greece-implications-for-human-exposure
#16
Christina Christia, Giulia Poma, Athanasios Besis, Constantini Samara, Adrian Covaci
Organophosphorus flame retardants (PFRs) and emerging PFRs (ePFRs) are two groups of compounds used as replacements for brominated flame retardants (BFRs). They have already been detected in indoor dust (mainly in homes and offices). To date, few studies investigated the occurrence of FRs in car dust and the information of possible health risks is still limited. The present study reports on the investigation of the levels and profiles of eight target PFRs: tris(2-ethylhexyl) phosphate (TEHP), tris(2-chloroethyl) phosphate (TCEP), tris(2-butoxyethyl) phosphate (TBEP), triphenyl phosphate (TPHP), 2-ethylhexyl diphenyl phosphate (EHDPHP), tris(1-chloro-2-propyl) phosphate (TCIPP), tri cresyl phosphate (TCP), tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and four target ePFRs; 2,2-bis(chloromethyl)propane-1,3-diyltetrakis(2-chloroethyl)bisphosphate (V6), isodecyl diphenyl phosphate (iDDPHP), resorcinol bis(diphenylphosphate) (RDP) and bisphenol A-bis(diphenyl phosphate) (BDP) in car dust from Greece...
December 23, 2017: Chemosphere
https://www.readbyqxmd.com/read/29302732/the-effects-of-platelet-rich-plasma-and-adipose-derived-stem-cells-on-neovascularization-and-fat-graft-survival
#17
Bing-Jun Xiong, Qiu-Wen Tan, Yu-Juan Chen, Yi Zhang, Di Zhang, Shen-Li Tang, Shu Zhang, Qing Lv
BACKGROUND: Adipose-derived stem cell (ADSCs)-assisted and platelet-rich plasma (PRP)-assisted lipofilling aim to enhance angiogenesis and cell proliferation and are promising techniques for lipofilling. This study aimed to compare the outcomes of ADSCs-assisted and PRP-assisted lipofilling. METHODS: Adipose tissue and human venous blood were obtained from women with early breast cancer. Human ADSCs were isolated and amplified in vitro. PRP was extracted through double centrifugation...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29300862/reproductive-alterations-in-chronically-exposed-female-mice-to-environmentally-relevant-doses-of-a-mixture-of-phthalates-and-alkylphenols
#18
Daniel Patiño-García, Leonor Cruz-Fernandes, Julio Buñay, Jaime Palomino, Ricardo D Moreno
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that modify hormone biosynthesis, causing adverse effects to human health. Among them, phthalates, and alkylphenols are important due to their wide use in plastics, detergents, personal care products, cosmetics and food packaging. However, their conjoint effects over reproductive female health have not been addressed. The aim of this work was to test the effect of chronically exposed female mice to a mixture of three phthalates [bis (2-ethylhexyl), dibutyl and benzyl butyl] and two alkylphenols [4-nonylphenol and 4-tert-octylphenol], from conception to adulthood at environmentally relevant doses...
December 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/29298730/cytokine-release-syndrome-after-radiation-therapy-case-report-and-review-of-the-literature
#19
Christopher A Barker, Samuel K Kim, Sadna Budhu, Konstantina Matsoukas, Anthony F Daniyan, Sandra P D'Angelo
BACKGROUND: Cytokine release syndrome (CRS) has been reported after immunologic manipulations, most often through therapeutic monoclonal antibodies. To our knowledge, CRS after radiation therapy (RT) for cancer has not been reported before. The development of unusual clinical signs and symptoms after RT led us to investigate the possibility of CRS after RT and review the medical literature on this topic. CASE PRESENTATION: A 65 year-old man with untreated chronic lymphocytic leukemia and recurrent, metastatic Merkel cell carcinoma undergoing anti-programmed death 1 (PD1) immunotherapy was referred for palliative RT to sites of progressing metastases...
January 3, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29290084/a-systematic-review-evaluating-the-effect-of-vitamin-b6-on-semen-quality
#20
Saleem Ali Banihani
PURPOSE: This review systematically discusses and summarizes the effect of vitamin B6 on semen quality. MATERIAL AND METHOD: To achieve this contribution, we searched the PubMed, Scopus, and Web of Science databases for English language papers from 1984 through 2017 using the key words "sperm" versus "Vitamin B6", "pyridoxine", and "pyridoxal". Also, the references from selected published papers were included, only if relevant. RESULT: To date, as revealed by rodent studies, high doses of vitamin B6 impair semen quality and sperm parameters...
December 30, 2017: Urology Journal
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