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Functional reconstruction

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https://www.readbyqxmd.com/read/29792351/peroxiredoxin-6-inhibits-osteogenic-differentiation-and-bone-formation-through-human-dental-pulp-stem-cells-and-induces-delayed-bone-development
#1
Kyung-Ran Park, Hyung-Mun Yun, In Jun Yeo, Sehyung Cho, Jin Tae Hong, Yong Seok Jeong
AIMS: Peroxiredoxins (PRDXs) are thiol-specific antioxidant enzymes that regulate redox balance that are critical for maintaining the cellular potential for self-renewal and stemness. Stem cell-based regenerative medicine is a promising approach in tissue reconstruction. However, to obtain functional cells for use in clinical applications, stem cell technology still requires improvements. RESULTS: In the present study, we found that PRDX6 levels were decreased during osteogenic differentiation in human dental pulp stem cells (hDPSCs)...
May 24, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29792110/a-comparative-study-of-anterior-cruciate-ligament-reconstruction-with-double-single-or-selective-bundle-techniques
#2
Zi-Yang Chia, Jade N Chee, Hamid Rahmatullah Bin-Abd-Razak, Denny Tt Lie, Paul Cc Chang
PURPOSE: Reconstruction of the anterior cruciate ligament (ACL) is the most frequently performed reconstructive surgery in the knee. Biomechanical studies have shown that double bundle (DB) reconstruction is better than single bundle (SB) reconstruction with regard to rotational stability. It is postulated that resection of ACL fibres that remain in continuity may be counterproductive for the knee as these fibres have the capacity to produce collagen. In this study, we aimed to evaluate the efficacy among selective bundle, DB and SB ACL reconstructions over a 2-year post-operative follow-up period...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29791927/treatment-outcome-of-reconstruction-for-isolated-posterior-cruciate-injury-subjective-and-objective-evaluations
#3
Satoshi Ochiai, Tetsuo Hagino, Shinya Senga, Takashi Yamashita, Hirotaka Haro
There is no consensus regarding the treatment method and outcome of posterior cruciate ligament (PCL) injury. We hypothesized that although the outcome of PCL reconstruction was favorable in terms of knee stability, the outcome was unsatisfactory in terms of patient-based assessments. The purpose of this study is to evaluate the treatment outcomes of knees that underwent reconstruction for PCL injury by subjective and objective assessments, and to analyze the correlation between various assessments. Twenty-three patients who underwent PCL reconstruction were studied...
May 23, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29791703/biological-intercalary-reconstruction-with-bone-grafts-after-joint-sparing-resection-of-the-lower-limb-is-this-an-effective-and-durable-solution-for-joint-preservation
#4
Francesco Muratori, Francesca Totti, Antonio D'Arienzo, Maurizio Scorianz, Guido Scoccianti, Giovanni Beltrami, Francesco Rosario Campo, Carmine Citarelli, Rodolfo Capanna, Domenico Andrea Campanacci
Due to advances in neoadjuvant therapies and preoperative imaging modalities, joint-sparing resections have become appealing in bone tumor surgery. However, the intercalary reconstruction of metadiaphyseal bone defects of the femur and the tibia after juxta-articular tumor resection remains challenging. Both biological and prosthetic reconstructions have been used for joint-sparing resections, but little is known about the long-term outcome of these procedures. The authors reviewed a consecutive series of 64 patients treated with joint-sparing intercalary resection and reconstruction with bone grafts...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791405/local-blur-analysis-and-phase-error-correction-method-for-fringe-projection-profilometry-systems
#5
Li Rao, Feipeng Da
We introduce a flexible error correction method for fringe projection profilometry (FPP) systems in the presence of local blur phenomenon. Local blur caused by global light transport such as camera defocus, projector defocus, and subsurface scattering will cause significant systematic errors in FPP systems. Previous methods, which adopt high-frequency patterns to separate the direct and global components, fail when the global light phenomenon occurs locally. In this paper, the influence of local blur on phase quality is thoroughly analyzed, and a concise error correction method is proposed to compensate the phase errors...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29790857/attenuation-correction-for-brain-pet-imaging-using-deep-neural-network-based-on-dixon-and-zte-mr-images
#6
Kuang Gong, Jaewon Yang, Kyungsang Kim, Georges El Fakhri, Youngho Seo, Quanzheng Li
Positron Emission Tomography (PET) is a functional imaging modality widely used in neuroscience studies. To obtain meaningful quantitative results from PET images, attenuation correction is necessary during image reconstruction. For PET/MR hybrid systems, PET attenuation is challenging as Magnetic Resonance (MR) images do not reflect attenuation coefficients directly. To address this issue, we present deep neural network methods to derive the continuous attenuation coefficients for brain PET imaging from MR images...
May 23, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29788059/impact-of-right-ventricular-volume-and-function-evaluated-using-cardiovascular-magnetic-resonance-imaging-on-outcomes-after-surgical-ventricular-reconstruction
#7
Sachiko Yamazaki, Satoshi Numata, Tomoya Inoue, Keiichi Itatani, Kazuki Morimoto, Suguru Ohira, Kaichiro Manabe, Isao Yokota, Hitoshi Yaku
OBJECTIVES: This study aimed to evaluate whether cardiac magnetic resonance imaging (MRI)-derived right ventricular (RV) assessment can facilitate risk stratification among patients with ischaemic cardiomyopathy who underwent surgical ventricular reconstruction (SVR). METHODS: We retrospectively analysed 53 patients who underwent SVR. The patients were preoperatively evaluated using cardiac MRI. Cine-MRI was acquired for left ventricular (LV) and RV volume. Gadolinium-enhanced MRI was performed to evaluate LV scarring...
May 17, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29787997/depth-based-whole-body-photoplethysmography-in-remote-pulmonary-function-testing
#8
Vahid Soleimani, Majid Mirmehdi, Dima Damen, Massimo Camplani, Sion Hannuna, Charles Sharp, James Dodd
OBJECTIVE: We propose a novel depth-based photoplethysmography (dPPG) approach to reduce motion artifacts in respiratory volume-time data and improve the accuracy of remote pulmonary function testing (PFT) measures. METHOD: Following spatial and temporal calibration of two opposing RGB-D sensors, a dynamic three-dimensional model of the subject performing PFT is reconstructed and used to decouple trunk movements from respiratory motions. Depth-based volume-time data is then retrieved, calibrated, and used to compute 11 clinical PFT measures for forced vital capacity and slow vital capacity spirometry tests...
June 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29787960/late-presentation-of-ectopia-vesica-with-malignant-transformation-a-case-report-and-review
#9
Sami Eldirdiri, Rehab M Elmushly, Sami G Elazhary
INTRODUCTION: Exstrophy of the bladder is a rare congenital anomaly usually treated in neonatal or childhood period. When combined with renal agenesis and presents for the first time in the adulthood with malignant transformation, is an extreme rarity. CASE PRESENTATION: We present a case of 65 years single male who presented with a right irreducible inguinal hernia and an unreconstructed Ectopia Vesicae with fungating tumor. He was anemic with impaired renal function, left renal agenesis and right sided hydronephrosis, hydroureter and distal ureteric stricture...
May 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29787697/rehabilitation-practice-patterns-following-anterior-cruciate-ligament-reconstruction-a-survey-of-physical-therapists
#10
Elliot M Greenberg, Eric T Greenberg, Jeffrey Albaugh, Eileen Storey, Theodore J Ganley
Study Design Cross-sectional survey. Background Recovery from anterior cruciate ligament reconstruction (ACLR) requires an intensive course of post-operative rehabilitation. Although guidelines outlining evidence-based rehabilitation recommendations have been published, the actual practice patterns of physical therapists are unknown. Objectives To analyze the current landscape of clinical practice as it pertains to rehabilitation progression and the use of time and objective criteria following ACLR. Methods An online survey was distributed to members of the orthopaedics, sports and private practice sections of the American Physical Therapy Association (APTA) between January and March 2017...
May 22, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29787549/long-term-patient-centered-outcomes-of-lower-extremity-vascular-trauma
#11
Zane B Perkins, Barbaros Yet, Simon Glasgow, William Marsh, Nigel R M Tai, Todd E Rasmussen
OBJECTIVE: To describe the long-term outcomes of military lower extremity vascular injuries, and the decision-making of surgeons treating these injuries. BACKGROUND: Lower extremity vascular trauma is an important cause of preventable death and severe disability, and decisions on amputation or limb salvage can be difficult. Additionally, the complexity of the condition is not amenable to controlled study, and there is limited data to guide clinical decision-making and establish sensible treatment expectations during rehabilitation...
May 4, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29787380/an-image-reconstruction-method-with-locally-adaptive-gating-scheme-for-pet-data
#12
Jizhe Wang, Yun Dong, Hongdi Li, Tao Feng
In conventional gating approaches for PET, a single number of gates is predetermined for the whole field of view (FOV) regardless of spatially variant motion blurring effects, which compromises image quality by under-gating regions of large motion and over-gating static regions. To achieve the best resolution-noise trade-off for the whole FOV, we proposed a new approach that incorporates spatially variant number of gates into gated image reconstruction. The first step is to estimate motion amplitude of each spatial location...
May 22, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29787360/myotarsal-flap-a-versatile-entity-for-lower-eyelid-reconstructions
#13
Hemant K Mehta
The purpose is to present a new surgical technique using myotarsal (MT) flap for reconstruction of small to subtotal full thickness defects - up to 8 mm in height - of lower eyelids, without needing concomitant supplementary procedures. MT flap consists of a 3 mm tarsal strip with attached levator complex. It does not have conjunctival lining or pedicle. Versatility of the flap extends to correction of mild to severe ptosis, and retraction of upper eyelids. This is a retrospective personal series of 163 patients, who underwent surgical reconstruction with MT flap overlaid with quilted skin graft (modified myotarsal flap) after excision of malignant tumours of lower eyelid...
June 2018: Orbit
https://www.readbyqxmd.com/read/29787301/innovative-surgical-treatment-of-severe-cherubism
#14
Ji H Son, Danielle C Marshall, Manish Valiathan, Todd Otteson, Gerald Ferretti, Paula A Grigorian, Carol Rosen, Devra Becker, David Rowe, Hooman Soltanian, Gregory Lakin
BACKGROUND: Cherubism is an autosomal dominant syndrome characterized by excessive bilateral maxillomandibular bony degeneration and fibrous tissue hyperplasia. Conservative management is the preferred treatment as cherubism has a self-limiting course. Functional or emotional disturbances may, however, demand surgical intervention. We report a patient who underwent surgical intervention. Method/Description: He had significant enlargement of lower cheeks and bilateral lower lid scleral show...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29787243/benchmark-analysis-of-native-and-artificial-nad-dependent-enzymes-generated-by-a-sequence-based-design-method-with-or-without-phylogenetic-data
#15
Shogo Nakano, Tomoharu Motoyama, Yurina Miyashita, Yuki Ishizuka, Naoya Matsuo, Hiroaki Tokiwa, Suguru Shinoda, Yasuhisa Asano, Sohei Ito
The expansion of protein sequence databases has enabled us to design artificial proteins by sequence-based design methods, such as full consensus design (FCD) and ancestral sequence reconstruction (ASR). Artificial proteins with enhanced activity levels compared with native ones can potentially be generated by such methods, but successful design is rare because preparing a sequence library by curating the database and selecting a method is difficult. Utilizing a curated library prepared by reducing conservation energies, we successfully designed two artificial L-threonine 3-dehydrogenase (SDR-TDH) with higher activity levels than native SDR-TDH, FcTDH-N1 and AncTDH, using FCD and ASR, respectively...
May 22, 2018: Biochemistry
https://www.readbyqxmd.com/read/29786575/spatial-organization-of-the-excretory-ducts-and-sections-of-microcirculatory-blood-flow-of-the-labial-salivary-glands-in-older-adults
#16
Volodymyr H Hryn, Tamara F Deineha, Аndrij V Piliuhin, Anna V Lavrenko, Dmytro O Lavrenko
OBJECTIVE: Introduction: Salivary glands have a significant impact on the state of the homeostasis of the human body, oral cavity in particular, sensitively responding to pathological processes. The reactivity of the salivary glands in response to pathological processes that are organically linked to morphology and functions of the organ's structures, and particularly the excretory ducts of the glands and their microcirculatory blood flow, is one of the problems which have not been solved to date...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786557/the-gene-regulatory-network-of-mesc-differentiation-a-benchmark-for-reverse-engineering-methods
#17
Johannes Meisig, Nils Blüthgen
A large body of data have accumulated that characterize the gene regulatory network of stem cells. Yet, a comprehensive and integrative understanding of this complex network is lacking. Network reverse engineering methods that use transcriptome data to derive these networks may help to uncover the topology in an unbiased way. Many methods exist that use co-expression to reconstruct networks. However, it remains unclear how these methods perform in the context of stem cell differentiation, as most systematic assessments have been made for regulatory networks of unicellular organisms...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786426/influence-of-enzyme-quantity-and-distribution-on-the-self-propulsion-of-non-janus-urease-powered-micromotors
#18
Tania Patiño, Natalia Feiner-Gracia, Xavier Arque, Albert Miguel-López, Anita Jannasch, Tom Stumpp, Erik Schäffer, Lorenzo Albertazzi, Samuel Sanchez
The use of enzyme catalysis to power micro and nanomachines offers unique features such as biocompatibility, versatili-ty and fuel bioavailability. Yet, the key parameters underlying the motion behavior of enzyme-powered motors are not completely understood. Here, we investigate the role of enzyme distribution and quantity on the generation of active mo-tion. Two different micromotor architectures based on either polystyrene (PS) or polystyrene coated with a rough silicon dioxide shell (PS@SiO2) were explored...
May 22, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29785626/sex-attractant-pheromones-of-virgin-queens-of-sympatric-slave-making-ant-species-in-the-genus-polyergus-and-their-possible-roles-in-reproductive-isolation
#19
Les Greenberg, Christine A Johnson, James C Trager, J Steven McElfresh, Joshua Rodstein, Jocelyn G Millar
Species of the ant genus Polyergus are social parasites that steal brood from colonies of their hosts in the closely related genus Formica. Upon emergence as adults in a mixed population, host Formica workers carry out all the normal worker functions within the Polyergus colony, including foraging, feeding, grooming, and rearing brood of the parasitic Polyergus ants. Some unmated Polyergus gynes (queens) run in the raiding columns of their colonies and attract males by releasing a pheromone from their mandibular glands...
May 22, 2018: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29785409/-de-novo-genome-and-transcriptome-resources-of-the-adzuki-bean-borer-ostrinia-scapulalis-lepidoptera-crambidae
#20
B Gschloessl, F Dorkeld, P Audiot, A Bretaudeau, C Kerdelhué, R Streiff
We present a draft genome assembly with a de novo prediction and automated functional annotation of coding genes, and a reference transcriptome of the Adzuki bean borer, Ostrinia scapulalis , based on RNA sequencing of various tissues and developmental stages. The genome assembly spans 419 Mb, has a GC content of 37.4% and includes 26,120 predicted coding genes. The reference transcriptome holds 33,080 unigenes and contains a high proportion of a set of genes conserved in eukaryotes and arthropods, used as quality assessment of the reconstructed transcripts...
April 2018: Data in Brief
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