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https://www.readbyqxmd.com/read/28734766/trpv1-modulates-morphine-induced-conditioned-place-preference-via-p38-mapk-in-the-nucleus-accumbens
#1
Sa-Ik Hong, Thi-Lien Nguyen, Shi-Xun Ma, Hyoung-Chun Kim, Seok-Yong Lee, Choon-Gon Jang
Emerging evidence suggests that the transient receptor potential vanilloid type 1 channel (TRPV1) is a novel target for the treatment of drug addiction, such as cocaine and morphine. Previously we reported that TRPV1 inhibition reduced morphine reward in the dorsal striatum (DSt) of mice and morphine self-administration through a decrease in accumbal activity in rats. However, the role of TRPV1 on morphine-conditioned reward in addiction-related brain regions, such as the nucleus accumbens (NAc), has not been previously established...
July 19, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28731362/greater-cognitive-deficits-with-sleep-disordered-breathing-among-individuals-with-genetic-susceptibility-to-alzheimer-s-disease-the-multi-ethnic-study-of-atherosclerosis
#2
Dayna A Johnson, Jacqueline Lane, Rui Wang, Michelle Reid, Ina Djonlagic, Annette L Fitzpatrick, Stephen R Rapp, Luenda E Charles, Ruth O'Hara, Richa Saxena, Susan Redline
RATIONALE: There are conflicting findings regarding the link between sleep apnea and cognitive dysfunction. OBJECTIVE: Investigate associations between indicators of sleep-disordered breathing (SDB) and cognitive function in the Multi-Ethnic Study of Atherosclerosis and assess effect modification by the apolipoprotein ε-4 (APOE-ε4) allele. METHODS: A diverse population (N=1,752) underwent Type 2 in-home polysomnography, which included measurement of % sleep time <90% oxyhemoglobin saturation (%Sat<90%) and apnea-hypopnea index (AHI)...
July 21, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28715917/self-reported-discomfort-associated-with-daylight-saving-time-in-brazilian-tropical-and-subtropical-zones
#3
João Carlos Nascimento de Alencar, Mario André Leocardio-Miguel, Leandro Lourenção Duarte, Fernando Louzada, John Fontenele Araujo, Mario Pedrazzoli
BACKGROUND: Daylight Saving Time (DST) annually moves clocks one hour forward, when daytime is longer than night. Previous studies from medium and high latitude locations have pointed to a disruptive effect of DST on human circadian rhythms. Since Brazil is an equatorial country implementing DST, a different relationship between photic and social synchronizers may interfere with DST effects. AIM: To explore the prevalence and duration of self-reported discomfort related to DST among Brazilian residents (lat...
July 17, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28709481/extensively-drug-resistant-tuberculosis-xdr-tb-a-daunting-challenge-to-the-current-end-tb-strategy-and-policy-recommendations
#4
REVIEW
Md Arifur Rahman, Atanu Sarkar
Extensively Drug-resistant Tuberculosis (XDR-TB) has emerged as one of the most formidable challenges to the End TB Strategy that has targeted a 95% reduction in TB deaths and 90% reduction in cases by 2035. Globally, there were an estimated 55,100 new XDR-TB cases in 2015 in 117 countries. However, only one in 30 XDR-TB cases had been reported so far. Drug susceptibility test (DST) is the mainstay for diagnosing XDR-TB, but the lack of laboratory facilities in the resource-limited endemic countries limit its uses...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28709094/fit-for-purpose-wastewater-treatment-conceptualization-to-development-of-decision-support-tool-i
#5
Gyan Chhipi-Shrestha, Kasun Hewage, Rehan Sadiq
This article is the first in a series of two papers. Paper I focuses on model conceptualization and development, and Paper II in the series focuses on model validation and implementation. The amount of water reuse has been increasing across the globe. Wastewater can be treated based on the intended end use of reclaimed water. Fit-for-purpose wastewater treatment (WWT) simultaneously considers intended end use, economic viability, and environmental sustainability. WWT technologies differ mainly in terms of treatment efficiency, cost, energy use, and associated carbon emissions...
July 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28708053/rapid-diagnosis-of-extrapulmonary-tuberculosis-with-xpert-mycobacterium-tuberculosis-rifampicin-assay
#6
Yan Li, Yu Pang, Tianhua Zhang, Xiaoping Xian, Xidi Wang, Jian Yang, Rui Wang, Meiling Chen, Wei Chen
PURPOSE: XpertMycobacterium tuberculosis/rifampicin (Xpert MTB/RIF) assay has been endorsed by the World Health Organization (WHO) for diagnosis of extrapulmonary tuberculosis (EPTB), while the sensitivity and specificity have not been fully evaluated. We aimed to evaluate the performance of Xpert MTB/RIF assay in the detection of different extrapulmonary specimens. METHODS: A total of 420 nonrespiratory specimens were detected with acid-fast bacilli (AFB) smear microscopy, solid culture, conventional drug susceptibility testing (DST) and Xpert MTB/RIF assay...
July 15, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28705265/comparison-of-histological-microbiological-and-molecular-methods-in-diagnosis-of-patients-with-tbln-having-different-anti-tb-treatment-background
#7
Nan Ying Che, Shao Jun Huang, Yan Ma, Yi Han, Zi Chen Liu, Chen Zhang, Jing Mu, Dan Zhao, Yang Qu, Hai Qing Zhang, Zhi Dong Liu, Shao Fa Xu
OBJECTIVE: The influence of anti-tuberculosis (TB) treatment history on tuberculous lymphadenitis (TBLN) diagnosis is unclear. Therefore, this study aims to evaluate the diagnostic methods, including histology, microbiology, and molecular tests, used for TBLN. METHODS: In this study, suspected patients with TBLN and having different anti-TB treatment background were enrolled. All the samples were tested simultaneously by histology, Ziehl-Neelsen (ZN) staining, mycobacterial culture (culture), Xpert MTB/RIF (xpert), real-time PCR, and high-resolution melting curve PCR (HRM)...
June 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28700973/fit-for-purpose-wastewater-treatment-testing-to-implementation-of-decision-support-tool-ii
#8
Gyan Chhipi-Shrestha, Kasun Hewage, Rehan Sadiq
This paper is the second in a series of two papers. In Paper I, a decision support tool (DST), FitWater, was developed for evaluating the potential of wastewater treatment (WWT) trains for various water reuse applications. In the present paper, the proposed DST has been tested and implemented. FitWater has been tested with several existing WWT plants in Canada and the USA, demonstrating FitWater's effectiveness in estimating life cycle cost (LCC), health risk, and energy use. FitWater has also been implemented in a newly planned neighbourhood in the Okanagan Valley (BC, Canada) by developing 12 alternative WWT trains for water reuse in lawn and public parks irrigation...
July 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28694139/systematic-review-and-meta-analysis-of-the-nitrate-reductase-assay-for-drug-susceptibility-testing-of-mycobacterium-tuberculosis-and-the-detection-limits-in-liquid-medium
#9
Miri Kwak, Won-Kyu Lee, Young Ju Lim, Seung Heon Lee, Sungweon Ryoo
Recently, the need for rapid, reliable, and low-cost drug susceptibility testing (DST) methods has increased due to the emergence of multidrug-resistant Mycobacterium tuberculosis. Colorimetric methods of DST provide results more quickly than standard culture methods and are inexpensive than molecular methods. Thus, colorimetric methods, such as the nitrate reductase assay (NRA), are being recommended. We searched Medline PubMed for reports on the NRA for DST of M. tuberculosis written in English and published within the last five years...
July 8, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28687019/effect-of-wound-fluid-on-chemotherapy-sensitivity-of-t24-bladder-cancer-cells-with-different-enhancer-of-zeste-homolog-2-status
#10
Huan Bi, Zetian Zhang, Li Guo, Cheng Fu
The present study investigated the effect of zeste homolog 2 (EZH2) and wound fluid (WF) on chemotherapy sensitivities of T24 bladder cancer cells by using a collagen gel droplet embedded culture-drug sensitivity test (CD-DST). T24 bladder cancer cells with different EZH2 expression levels were co-cultured with postoperative WF from patients with bladder cancer. The CD-DST was performed to detect the sensitivity of tumor cells to gemcitabine and cis-diamminedichloridoplatinum (II) (cisplatin, DDP). The survival rates of the bladder cancer cells were used to determine the drug's chemotherapeutic effect...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28685068/protein-and-mrna-expression-of-folic-acid-associated-enzymes-as-biomarkers-for-the-cytotoxicity-of-the-thymidylate-synthase-targeted-drugs-pemetrexed-and-s-1-in-non-small-cell-lung-cancer
#11
Madoka Kimura, Fumio Imamura, Takako Inoue, Kazumi Nishino, Junji Uchida, Toru Kumagai, Jiro Okami, Masahiko Higasiyama, Shingo Kamoshida
The thymidylate synthase (TS)-targeted drugs, pemetrexed and S-1, exert an important role in advanced non-small cell lung cancer (NSCLC) treatment; folic acid-associated enzymes are expected to behave as biomarkers, although their role has yet to be fully elucidated. In the present study, a single-institutional prospective analysis, in which the mRNA and protein expression levels of five folic acid-associated enzymes were evaluated with surgical specimens of NSCLC, was performed. Drug sensitivity was evaluated using a collagen gel droplet-embedded culture drug sensitivity test (CD-DST) in vitro...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28684860/neuroinflammation-in-obesity-circulating-lipopolysaccharide-binding-protein-associates-with-brain-structure-and-cognitive-performance
#12
J M Moreno-Navarrete, G Blasco, J Puig, C Biarnés, M Rivero, J Gich, F Fernández-Aranda, J Garre-Olmo, L Ramió-Torrentà, Á Alberich-Bayarri, F G Castro, S Pedraza, W Ricart, J M Fernández-Real
BACKGROUND/OBJECTIVES: Growing evidence implicates neuroinflammation in the pathogenesis of diet-induced obesity and cognitive dysfunction in rodent models. Obesity is associated with reduced white matter integrity and cognitive decline. Circulating lipopolysaccharide binding protein (LBP) concentration is known to be increased in patients with obesity. Here, we aimed to evaluate whether circulating LBP is associated longitudinally with white matter structure and cognitive performance according to obesity status...
July 7, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28674131/impact-of-daylight-saving-time-on-road-traffic-collision-risk-a-systematic-review
#13
Rachel N Carey, Kiran M Sarma
BACKGROUND: Bills have been put forward in the UK and Republic of Ireland proposing a move to Central European Time (CET). Proponents argue that such a change will have benefits for road safety, with daylight being shifted from the morning, when collision risk is lower, to the evening, when risk is higher. Studies examining the impact of daylight saving time (DST) on road traffic collision risk can help inform the debate on the potential road safety benefits of a move to CET. The objective of this systematic review was to examine the impact of DST on collision risk...
July 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28670192/the-occurrence-of-subclinical-hypercortisolism-and-osteoporosis-in-patients-with-incidentally-discovered-unilateral-and-bilateral-adrenal-tumors
#14
Sanja Ognjanović, Djuro Macut, Milan Petakov, Valentina Elezović Kovačević, Tatjana Isailović, Ivana Bozić Antić, Dušan Ilić, Bojana Popović, Tamara Bogavac, Tatjana Pekmezović, Svetozar Damjanović
BACKGROUND: Adrenal incidentalomas (AI) are clinically silent adrenal masses that are detected incidentally during imaging procedures performed for unrelated diseases. The aim of this study was to investigate the prevalence of sub-clinical hypercortisolism (SH) and associated co-morbidities in patients with unilateral AI (UAI) and bilateral AI (BAI). METHODS: We evaluated 152 patients, 105 (69.1%) with UAI and 47 (30.9%) with BAI. SH was diagnosed in the presence of serum cortisol levels after 1 mg dexamethasone suppression test (DST) or after 2-day low-dose DST (LDDST) > 50 nmol/L with at least one of the following parameters: midnight serum cortisol > 208 nmol/L, 24-h urinary free cortisol > 245 nmol/24 h, or ACTH < 10 ng/L...
October 2016: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28664402/reduced-proliferation-of-oligodendrocyte-progenitor-cells-in-the-postnatal-brain-of-dystonia-musculorum-mice
#15
M Ibrahim Hossain, Masao Horie, Hirohide Takebayashi
Dystonia musculorum (dt) mice show sensory neurodegeneration and movement disorder, such as dystonia and cerebellar ataxia. The causative gene Dystonin (Dst) encodes a cytoskeleton linker protein. Although sensory neurodegeneration has been well studied, glial cell responses in the central nervous system (CNS) are poorly understood. Here, we investigated cell proliferation in the CNS of Dst (Gt) homozygous mice using newly generated in situ hybridization (ISH) probes-Ki-67 and proliferating cell nuclear antigen (PCNA) probes-both of which effectively detect proliferating cells...
June 29, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28656620/autonomous-cortisol-secretion-in-adrenal-incidentalomas-and-increased-visceral-fat-accumulation-during-follow-up
#16
Serkan Yener, Mustafa Baris, Ahmet Peker, Omer Demir, Basak Ozgen, Mustafa Secil
OBJECTIVE: Autonomous cortisol secretion of adrenal incidentalomas (AIs) is associated with poor cardiovascular outcome. Because centripetal obesity is a cardiovascular risk factor, we aimed to investigate whether autonomous cortisol secretion is associated with increased visceral fat accumulation. DESIGN: Retrospective cohort study. PATIENTS: Patients with AIs who attended for follow-up between January 2014 and December 2016 were evaluated...
June 28, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28648496/fruits-as-the-vehicle-of-drug-resistant-pathogenic-yeasts
#17
Hsiu-Jung Lo, Sheng-Hua Tsai, Wen-Li Chu, Yin-Zhi Chen, Zi-Li Zhou, Hong-Fu Chen, Ching-Fu Lee, Yun-Liang Yang
OBJECTIVE: We investigated the diversity and drug susceptibility of pathogenic yeasts on fruit surfaces. METHOD: Fruits were purchased from supermarkets and washed with buffer. The pellets were re-suspended in medium after centrifugation. The cell suspensions were plated onto CHROMagar Candida medium. Yeasts were identified by ribosomal DNA sequencing and their drug susceptibilities were determined by broth microdilution assay. RESULTS: Of 184 isolates, comprised of 55 species, from 22 different types of fruits, 29 species, including Candida famata, Candida fermentati, Candida guilliermondii, Candida intermedia, Candida krusei, Candida orthopsilosis, Candida parapsilosis, Candida pelliculosa, Candida tropicalis, and others have been reported to cause diseases in humans...
June 23, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28646901/effect-of-ezetimibe-add-on-therapy-over-52%C3%A2-weeks-extension-analysis-of-prospective-randomized-trial-research-study-in-type-2-diabetes-subjects
#18
Kentaro Sakamoto, Mitsunobu Kawamura, Takayuki Watanabe, Keiko Ashidate, Takahide Kohro, Akira Tanaka, Yasumichi Mori, Motoki Tagami, Tsutomu Hirano, Tsutomu Yamazaki, Teruo Shiba
BACKGROUND: Lowering cholesterol levels decreases the risk of atherosclerotic diseases. Effective ways to stably reduce LDL-C level are warranted in type 2 diabetic patients, a high-risk population for CVD, with various anti-diabetic therapeutic background. The RESEARCH study focuses on LDL-C reduction in this population along with modifications of the lipid profiles. We evaluated long-term ezetimibe add-on therapy in T2DM patients with hypercholesterolemia. METHODS: In a randomized, multicenter, open-label, prospective study, a total of 109 T2DM patients not attaining LDL-C target value despite first-line dose statin (10 mg of atorvastatin or 1 mg of pitavastatin) therapy in Japan were recruited...
June 24, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28639565/diagnostic-performance-of-the-genotype-mtbdrplus-and-mtbdrsl-assays-to-identify-tuberculosis-drug-resistance-in-eastern-china
#19
Qiao Liu, Guo-Li Li, Cheng Chen, Jian-Ming Wang, Leonardo Martinez, Wei Lu, Li-Mei Zhu
BACKGROUND: The WHO recently has recommended the GenoType MTBDRplus version 1.0 and MTBDRsl version 1.0 assays for widespread use in countries endemic with drug-resistant tuberculosis. Despite this, these assays have rarely been evaluated in China, where the burden of drug-resistant tuberculosis is among the highest globally. METHODS: Mycobacterium tuberculosis clinical isolates were obtained between January 2008 and December 2008. Isolates were tested for drug resistance against rifampicin (RFP) and isoniazid (INH) using the GenoType MTBDRplus assay and drug resistance against ethambutol (EMB), ofloxacin (OFX), and kanamycin (KM) using the Genotype MTBDRsl assay...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28637948/in-the-overnight-dexamethasone-suppression-test-1-0-mg-loading-is-superior-to-0-5-mg-loading-for-diagnosing-subclinical-adrenal-cushing-s-syndrome-based-on-plasma-dexamethasone-levels-determined-using-liquid-chromatography-tandem-mass-spectrometry
#20
Yosuke Sasaki, Takuyuki Katabami, Shiko Asai, Hisashi Fukuda, Yasushi Tanaka
The low-dose dexamethasone suppression test (DST) is one of the commonly used initial tests for endogenous Cushing's syndrome (CS). However, there are two loading dose regimens (0.5-mg and 1-mg), which may cause some confusion in daily practice in Japan; furthermore, there are no reports regarding whether 0.5-mg DST is a better loading dose for detecting adrenal subclinical CS (SCS) based on the plasma dexamethasone (DEX) levels. Therefore, the aims of this study were (a) to develop a novel assay to measure DEX by using liquid chromatography tandem-mass spectrometry (LC-MS/MS) and (b) to compare between the 0...
June 21, 2017: Endocrine Journal
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