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macular degeneration in young people

https://read.qxmd.com/read/37001591/association-between-sight-threatening-eye-diseases-and-death-by-suicide-in-south-korea-a-nationwide-population-based-cohort-study
#1
JOURNAL ARTICLE
Ahnul Ha, Su Hwan Kim, Goneui Kang, Hyung-Jin Yoon, Young Kook Kim
PURPOSE: Although associations between visual impairment (VI) and suicide are posited, specific risks across the sight-threatening eye disease (STED) spectrum remain to be assessed. We determined whether individuals with STED die more often by suicide than do other people and assessed the temporal associations. DESIGN: A nationwide, population-based cohort study. PARTICIPANTS: All persons aged 40 years or older in South Korea from 2010 to 2020...
August 2023: Ophthalmology
https://read.qxmd.com/read/36464210/the-role-of-statins-in-diabetic-retinopathy
#2
REVIEW
Oren Tomkins-Netzer, Rachael Niederer, Susan Lightman
Diabetes mellitus is a growing global public health issue estimated to affect around 600 million people by 2040 [1]. It occurs in populations throughout the world, is increasing in both the developing world and high-income countries and also affects young, working-age people. Ocular involvement in diabetes occurs early in the disease and is present in over a third of diabetes mellitus Type 2 patients at the time of diagnosis. Blindness due to diabetic retinopathy (DR) remains a leading cause of adult-onset blindness, [1] which results from disruption of retinal vasculature, ischemia and its consequences and exudation causing macular edema...
December 2, 2022: Trends in Cardiovascular Medicine
https://read.qxmd.com/read/36349586/indoor-air-pollution-and-human-ocular-diseases-associated-contaminants-and-underlying-pathological-mechanisms
#3
REVIEW
Dan-Lei Yang, Zhen-Ning Zhang, Hai Liu, Zi-Yue Yang, Mi-Mi Liu, Qin-Xiang Zheng, Wei Chen, Ping Xiang
People spend a long time indoors, especially young children. The risk of indoor pollution on human health is one of the current hotspots in environmental and public health. The human ocular surface is highly susceptible to indoor environment quality. Epidemiological data have linked human ophthalmological disorders with exposure to indoor pollution. In this review, we summarized the adverse impacts of indoor pollution on the human ocular surface. Several studies demonstrated that indoor contaminants including particulate matter, volatile/semi-volatile organic compounds, heavy metals, and fuel combustion and cigarette smoke exposure were associated with the incidence of human dry eye, conjunctivitis, glaucoma, cataracts, age-related macular degeneration, and keratitis...
October 28, 2022: Chemosphere
https://read.qxmd.com/read/36090287/enhancing-socio-emotional-communication-and-quality-of-life-in-young-cochlear-implant-recipients-perspectives-from-parameter-specific-morphing-and-caricaturing
#4
JOURNAL ARTICLE
Stefan R Schweinberger, Celina I von Eiff
The use of digitally modified stimuli with enhanced diagnostic information to improve verbal communication in children with sensory or central handicaps was pioneered by Tallal and colleagues in 1996, who targeted speech comprehension in language-learning impaired children. Today, researchers are aware that successful communication cannot be reduced to linguistic information-it depends strongly on the quality of communication, including non-verbal socio-emotional communication. In children with cochlear implants (CIs), quality of life (QoL) is affected, but this can be related to the ability to recognize emotions in a voice rather than speech comprehension alone...
2022: Frontiers in Neuroscience
https://read.qxmd.com/read/36081228/impact-of-neovascular-age-related-macular-degeneration-on-eye-movement-control-during-scene-viewing-viewing-biases-and-guidance-by-visual-salience
#5
JOURNAL ARTICLE
Antje Nuthmann, Miguel Thibaut, Thi Ha Chau Tran, Muriel Boucart
Human vision requires us to analyze the visual periphery to decide where to fixate next. In the present study, we investigated this process in people with age-related macular degeneration (AMD). In particular, we examined viewing biases and the extent to which visual salience guides fixation selection during free-viewing of naturalistic scenes. We used an approach combining generalized linear mixed modeling (GLMM) with a-priori scene parcellation. This method allows one to investigate group differences in terms of scene coverage and observers' well-known tendency to look at the center of scene images...
September 5, 2022: Vision Research
https://read.qxmd.com/read/35810276/severity-of-age-related-macular-degeneration-at-first-presentation-in-bhutan-a-3-year-national-study
#6
JOURNAL ARTICLE
Bhim B Rai, Michael G Morley, Paul S Bernstein, Ted Maddess
BACKGROUND: Medical services are still developing in Bhutan. There is no published national report on age-related macular degeneration (AMD). We therefore aim to determine the demographic characteristics and severity of AMD at first presentation among Bhutanese patients attending their recently inaugurated vitreoretinal (VR) clinics over a 3-year national survey, and to inform national health policy to develop suitable health program to prevent AMD-related blindness and visual impairment...
July 9, 2022: BMC Ophthalmology
https://read.qxmd.com/read/34977924/ten-year-mortality-and-long-term-visual-acuity-outcomes-in-patients-with-exudative-age-related-macular-degeneration-treated-with-intravitreal-anti-vascular-endothelial-growth-factor-injections
#7
JOURNAL ARTICLE
Su Ling Young, Martin J Anderson, Shyamanga Borooah, Ana-Maria Armbrecht, Peter D Cackett
PURPOSE: There are limited real-world data on long-term mortality and visual outcomes in patients treated with anti-vascular endothelial growth factor (VEGF) for exudative age-related macular degeneration (exudative AMD). We assessed 10-year mortality and clinical outcomes in exudative AMD patients treated with intravitreal therapy (IVT) anti-VEGF injections on a pro-re-nata (PRN) regime following a standard loading regime. METHODS: Retrospective cohort study of the first 216 exudative AMD patients receiving IVT anti-VEGF for exudative AMD at a public tertiary referral hospital in Scotland...
January 6, 2022: Age and Ageing
https://read.qxmd.com/read/34298993/features-of-retinal-neurogenesis-as-a-key-factor-of-age-related-neurodegeneration-myth-or-reality
#8
REVIEW
Darya V Telegina, Oyuna S Kozhevnikova, Anna K Antonenko, Nataliya G Kolosova
Age-related macular degeneration (AMD) is a complex multifactorial neurodegenerative disease that constitutes the most common cause of irreversible blindness in the elderly in the developed countries. Incomplete knowledge about its pathogenesis prevents the search for effective methods of prevention and treatment of AMD, primarily of its "dry" type which is by far the most common (90% of all AMD cases). In the recent years, AMD has become "younger": late stages of the disease are now detected in relatively young people...
July 9, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/32188679/prevalence-of-myopic-macular-degeneration-worldwide-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Minjie Zou, Shibin Wang, Aiming Chen, Zhenzhen Liu, Charlotte Aimee Young, Yichi Zhang, Guangming Jin, Danying Zheng
PURPOSE: To investigate the prevalence of myopic macular degeneration (MMD) in the global population. METHODS: All published literature of population-based studies on MMD prevalence worldwide were searched and only those with clear definitions to diagnose and classify MMD lesions by standardised grading methods were selected. Meta-analysis methods were used to calculate the pooled prevalence of MMD and its 95% CI in a random-effects model. The prevalence of MMD lesions would also be reported, together with the subgroup analysis of age, region and gender...
December 2020: British Journal of Ophthalmology
https://read.qxmd.com/read/31646003/in-vitro-differentiation-of-cgmp-grade-retinal-pigmented-epithelium-from-human-embryonic-stem-cells
#10
JOURNAL ARTICLE
Fernando H Lojudice, Rodrigo A Brant Fernandes, Francesco Innocenti, Carlos E Franciozi, Priscila Cristovam, Maurício Maia, Mari C Sogayar, Rubens Belfort Junior
Background: The World Health Organization (WHO) estimates that the number of individuals who lose their vision due to retinal degeneration is expected to reach 6 million annually in 2020. The retinal degenerative diseases affect the macula, which is responsible for central and detailed vision. Most macular degeneration, i.e., age-related macular degeneration (AMD) develops in the elderly; however, certain hereditary diseases, such as the Stargardt disease, also affect young people. This degeneration begins with loss of retinal pigmented epithelium (RPE) due to formation of drusen (atrophic) or abnormal vessels (exudative)...
2019: International Journal of Retina and Vitreous
https://read.qxmd.com/read/31381895/investigation-of-the-preventive-effect-of-calcium-on-inflammation-mediated-choroidal-neovascularization
#11
JOURNAL ARTICLE
In Sung Sung, Seon Young Park, Keun-Yeong Jeong, Hwan Mook Kim
AIMS: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in elderly people. The pathogenesis of neovascular AMD is known but is closely related to inflammation and choroidal neovascularization (CNV). The aim of this study was to investigate the anti-inflammatory and anti-angiogenic effects of calcium on neovascular AMD. MAIN METHODS: Human retinal pigment epithelial cells (ARPE-19) were used to identify protein markers of inflammation induced by differentiated macrophages...
August 2, 2019: Life Sciences
https://read.qxmd.com/read/31268226/prevalence-of-age-related-macular-degeneration-in-chinese-populations-worldwide-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Guangming Jin, Minjie Zou, Aiming Chen, Yichi Zhang, Charlotte A Young, Shi-Bin Wang, Danying Zheng
IMPORTANCE: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness, but the magnitude of AMD among Chinese populations worldwide is still unknown. BACKGROUND: To investigate the prevalence of AMD in Chinese populations worldwide. DESIGN: Meta-analysis. PARTICIPANTS: Nine studies with 29 344 subjects in total. METHODS: All population-based studies on AMD prevalence in Chinese populations worldwide were identified and only studies using standardized AMD grading systems (Wisconsin Age-Related Maculopathy Grading System, Age-Related Eye Disease Study System of Classifying AMD, the International Classification and Grading System for AMD or the Clinical Classification of Age-Related Macular Degeneration) were included...
November 2019: Clinical & Experimental Ophthalmology
https://read.qxmd.com/read/31224957/the-content-of-lutein-and-zeaxanthin-in-the-diet-of-young-health-people-p02-006-19
#13
JOURNAL ARTICLE
Aleksei Korolev, Ekaterina Kirpichenkova, Elena Nikitenko, Elena Denisova
Objectives: Lutein and zeaxanthin are non-vitamin carotenoids, which located in macula. These carotenoids reduce the risk of progression of age-related macular degeneration. The purpose of research to analyze the amount of lutein and zeaxanthin in diets of young health people and to asses food choices rich non-vitamin carotenoids. Methods: Adults aged 20-25 y ( n  = 424, 113 males age 22.0 ± 0.9 y, 311 females age 22.0 ± 0.8 y). Lutein and zeaxanthin levels from food sources have been estimated using the 24-hour recall method...
June 2019: Current Developments in Nutrition
https://read.qxmd.com/read/30592887/-study-of-lutein-and-zeaxanthin-content-in-the-diet-with-the-assessment-of-the-relationship-between-the-level-of-alimentary-intake-of-non-vitamin-carotenoids-and-the-density-of-the-macular-region-of-the-retina-at-a-young-age
#14
JOURNAL ARTICLE
E V Kirpichenkova, A A Korolev, G G Onishchenko, E I Nikitenko, D V Lipatov, A G Kuz'min, Yu A Dyskin, E L Denisova, R N Fetisov
Lutein and zeaxanthin are carotenoid pigments that affect the function of the visual analyzer. They selectively accumulate in the yellow spot of the retina, form macular pigment and determine the density of the retina macula. Lutein and zeaxanthin slow down the progression of age-related macular degeneration, a leading cause of senior-age blindness. The main food sources of non-vitamin carotenoids are green leafy vegetables, zucchini, pumpkin, green peas, broccoli. The aim of the study is a retrospective assessment of the levels and sources of alimentary intake of lutein and zeaxanthin in young people and research of the effect of lutein and zeaxanthin in the diet on macula density...
2018: Voprosy Pitaniia
https://read.qxmd.com/read/30315188/improving-face-identity-perception-in-age-related-macular-degeneration-via-caricaturing
#15
JOURNAL ARTICLE
Jo Lane, Emilie M F Rohan, Faran Sabeti, Rohan W Essex, Ted Maddess, Nick Barnes, Xuming He, Rachel A Robbins, Tamara Gradden, Elinor McKone
Patients with age-related macular degeneration (AMD) have difficulty recognising people's faces. We tested whether this could be improved using caricaturing: an image enhancement procedure derived from cortical coding in a perceptual 'face-space'. Caricaturing exaggerates the distinctive ways in which an individual's face shape differs from the average. We tested 19 AMD-affected eyes (from 12 patients; ages 66-93 years) monocularly, selected to cover the full range of vision loss. Patients rated how different in identity people's faces appeared when compared in pairs (e...
October 12, 2018: Scientific Reports
https://read.qxmd.com/read/27825655/mediterranean-diet-score-and-its-association-with-age-related-macular-degeneration-the-european-eye-study
#16
MULTICENTER STUDY
Ruth E Hogg, Jayne V Woodside, Alanna McGrath, Ian S Young, Jesus L Vioque, Usha Chakravarthy, Paulus T de Jong, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Astrid E Fletcher
PURPOSE: To examine associations between adherence to a Mediterranean diet and prevalence of age-related macular degeneration (AMD) in countries ranging from Southern to Northern Europe. DESIGN: Cross-sectional, population-based epidemiologic study. PARTICIPANTS: Of 5060 randomly sampled people aged 65 years or older from 7 study centers across Europe (Norway, Estonia, United Kingdom, France, Italy, Greece, and Spain), full dietary data were available in 4753...
January 2017: Ophthalmology
https://read.qxmd.com/read/26707755/visual-exploration-of-objects-and-scenes-in-patients-with-age-related-macular-degeneration
#17
JOURNAL ARTICLE
M Thibaut, C Delerue, M Boucart, T H C Tran
OBJECTIVE: Studies on people with age-related macular degeneration (AMD) have shown that they are able to detect briefly displayed objects and scenes with high accuracy (above 80%). However, in everyday life we explore our environment to search and to recognize objects. We assessed visual exploration in people with AMD during the identification of objects and scenes. METHOD: Twenty patients with AMD, fifteen age-matched and twelve young controls participated. We used colored photographs of isolated objects, natural scenes and objects in scenes, displayed centrally on a monitor...
January 2016: Journal Français D'ophtalmologie
https://read.qxmd.com/read/26326675/age-related-changes-in-gray-and-white-matter-microstucture-of-patients-with-macular-dystrophies-and-healthy-controls-as-revealed-by-dti
#18
JOURNAL ARTICLE
Anton Beer, Sang-Yee Go, Tina Plank, Mark Greenlee
Previous research has shown that loss of central vision resulting from macular degeneration not only affects functional processing but also the macroscopic structure of the visual pathway. In particular, magnetic resonance imaging (MRI) showed volumetric reductions of the gray and white matter of patients with macular degeneration in portions of the calcarine sulcus that represent the central visual field. However, the basis of these macrostructural alterations due to partial vision loss is still unclear. Diffusion tensor imaging (DTI) based on MRI is a technique that allows inferences about the microstructure of brain tissue...
2015: Journal of Vision
https://read.qxmd.com/read/25847590/misidentifying-a-tennis-racket-as-keys-object-identification-in-people-with-age-related-macular-degeneration
#19
JOURNAL ARTICLE
Miguel Thibaut, Thi Ha Chau Tran, Céline Delerue, Muriel Boucart
PURPOSE: Previous studies showed that people with age-related macular degeneration (AMD) can categorise a pre-defined target object or scene with high accuracy (above 80%). In these studies participants were asked to detect the target (e.g. an animal) in serial visual presentation. People with AMD must rely on peripheral vision which is more adapted to the low resolution required for detection than for the higher resolution required to identify a specific exemplar. We investigated the ability of people with central vision loss to identify photographs of objects and scenes...
May 2015: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://read.qxmd.com/read/24732768/approaches-to-cell-delivery-substrates-and-scaffolds-for-cell-therapy
#20
REVIEW
Joydip Kundu, Andrew Michaelson, Petr Baranov, Michael J Young, Rebecca L Carrier
Retinal degeneration, associated with loss of photoreceptors, is the primary cause of permanent vision impairment, impacting millions of people worldwide. Age-related macular degeneration and retinitis pigmentosa are two common retinal diseases resulting in photoreceptor loss and vision impairment or blindness. Presently, available treatments can only delay the progress of retinal degeneration, and there are no treatments that can restore permanent vision loss. Research is underway to develop methods of regenerating the impaired retina by delivering photoreceptor precursor cells and retinal pigment epithelium to the subretinal space...
2014: Developments in Ophthalmology
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