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https://www.readbyqxmd.com/read/29049357/associations-of-health-status-with-subsequent-blood-donor-behavior-an-alternative-perspective-on-the-healthy-donor-effect-from-donor-insight
#1
Katja van den Hurk, Saurabh Zalpuri, Femmeke J Prinsze, Eva-Maria Merz, Wim L A M de Kort
INTRODUCTION: In donor health research, the 'Healthy Donor Effect' (HDE) often biases study results and hampers their interpretation. This refers to the fact that donors are a selected 'healthier' subset of a population due to both donor selection procedures and self-selection. Donors with long versus short donor careers, or with high versus low donation intensities are often compared to avoid this HDE, but underlying health differences might also cause these differences in behaviour...
2017: PloS One
https://www.readbyqxmd.com/read/29049302/connectivity-maps-based-analysis-of-eeg-for-the-advanced-diagnosis-of-schizophrenia-attributes
#2
Zack Dvey-Aharon, Noa Fogelson, Abraham Peled, Nathan Intrator
This article presents a novel connectivity analysis method that is suitable for multi-node networks such as EEG, MEG or EcOG electrode recordings. Its diagnostic power and ability to interpret brain states in schizophrenia is demonstrated on a set of 50 subjects that constituted of 25 healthy and 25 diagnosed with schizophrenia and treated with medication. The method can also be used for the automatic detection of schizophrenia; it exhibits higher sensitivity than state-of-the-art methods with no false positives...
2017: PloS One
https://www.readbyqxmd.com/read/29049197/value-of-evaluating-procalcitonin-kinetics-in-diagnosis-of-infections-in-patients-undergoing-laparoscopic-radical-cystectomy
#3
Xiangli Ding, Delin Yang, Changxing Ke, Long Gong, Hui Zhan, Ruping Yan, Yan Chen, Haiyuan Li, Jiansong Wang
Postsurgery infection is a common complication after laparoscopic radical cystectomy (LRC) followed by urinary diversion. White blood cell (WBC) values and C-reactive protein (CRP) are routinely used as markers for infection, but lack of specificity and their elevation is often delayed in clinically significant events. In this study, we aimed to investigate the value of procalcitonin (PCT) kinetics in assisting early diagnosis of infection in patients undergoing LRC.The patients' medical records between May 2013 and May 2016 were reviewed retrospectively...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29045714/the-psychological-health-of-remote-area-medics-in-iraq
#4
S Whittaker-Howe, G Brown, V Williamson, N Greenberg
Background: Remote area medics (RAMs) may be at increased risk of mental health difficulties. Aims: To explore the occupational experiences of RAMs to identify stressors and the mental health impact. Methods: Semi-structured interviews were conducted with six RAMs working in Iraq to gather data, which was explored using interpretative phenomenological analysis. Results: Three key themes emerged from the data (i) the experience of being remote, (ii) cultural shock and (iii) social support...
October 17, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29045504/molecular-tumor-boards-current-practice-and-future-needs
#5
D L van der Velden, C M L van Herpen, H W M van Laarhoven, E F Smit, H J M Groen, S M Willems, P M Nederlof, M H G Langenberg, E Cuppen, S Sleijfer, N Steeghs, E E Voest
Background: due to rapid technical advances, steeply declining sequencing costs, and the ever-increasing number of targeted therapies, it can be expected that extensive tumor sequencing such as Whole Exome- and -Genome Sequencing will soon be applied in standard care. Clinicians will thus be confronted with increasingly complex genetic information and multiple test-platforms to choose from. General medical training, meanwhile, can hardly keep up with the pace of innovation. Consequently, there is a rapidly growing gap between clinical knowledge and genetic potential in cancer care...
September 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045273/oneflorida-clinical-research-consortium-linking-a-clinical-and-translational-science-institute-with-a-community-based-distributive-medical-education-model
#6
Elizabeth Shenkman, Myra Hurt, William Hogan, Olveen Carrasquillo, Steven Smith, Andrew Brickman, David Nelson
PROBLEM: Developing a national pragmatic clinical trial infrastructure is central to understanding the effectiveness of interventions applied under usual conditions and where people receive health care. To address this challenge, three Florida universities- the University of Florida Clinical and Translational Science Institute, Florida State University (with its community-based distributive medical education model), and the University of Miami-created (2010-2013) a statewide consortium, the OneFlorida Clinical Research Consortium, to support the conduct of pragmatic clinical trials and provide mentored research experiences for medical and graduate students in real-world practice settings...
October 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29043581/the-unique-blood-pressures-and-pulsatility-of-lvad-patients-current-challenges-and-future-opportunities
#7
REVIEW
Francesco Castagna, Eric J Stöhr, Alberto Pinsino, John R Cockcroft, Joshua Willey, A Reshad Garan, Veli K Topkara, Paolo C Colombo, Melana Yuzefpolskaya, Barry J McDonnell
An increasing number of end-stage heart failure patients are now implanted with continuous-flow left ventricular assist devices (CF-LVADs). Although this therapeutic approach is associated with improved clinical outcomes, continuous flow physiology reduces arterial pulse pressure and pulsatility to an extent that is unique to this population. Recent data suggest that high blood pressure (BP) contributes to life-threatening complications such as pump thrombosis and stroke of CF-LVAD patients. However, limited understanding of the distinct hemodynamics of these pumps makes measurement and, consequently, medical management of BP quite challenging...
October 18, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/29042095/can-emergency-physicians-accurately-distinguish-retinal-detachment-from-posterior-vitreous-detachment-with-point-of-care-ocular-ultrasound
#8
Nicola Baker, Richard Amini, Elaine H Situ-LaCasse, Josie Acuña, Tomas Nuño, Uwe Stolz, Srikar Adhikari
STUDY OBJECTIVE: There is significant overlap between the symptoms of patients presenting with retinal detachment (RD) and posterior vitreous detachment (PVD). Urgency to obtain consultation and treatment are dependent on the ability to accurately distinguish these two conditions. The objective of this study was to determine the ability of emergency physicians to differentiate RDs from PVDs using point-of-care (POC) ocular ultrasound. METHODS: Single blinded cross-sectional study at an academic medical center...
October 13, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29040553/longitudinal-depression-or-anxiety-in-mothers-and-offspring-asthma-a-swedish-population-based-study
#9
Bronwyn K Brew, Cecilia Lundholm, Alexander Viktorin, Paul Lichtenstein, Henrik Larsson, Catarina Almqvist
Background: Previous research has found that maternal stress during pregnancy increases the risk of offspring asthma. However, whether this association is consistent with a causal interpretation has never been tested. The objective is to determine whether there is a critical exposure period for maternal depression or anxiety on offspring asthma or whether cumulative exposure is most important, and to investigate evidence of confounding. Methods: The study population included all children born in Sweden from July 2006 to December 2009 (n = 360 526)...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040453/detection-of-sputum-by-interpreting-the-time-frequency-distribution-of-respiratory-sound-signal-using-image-processing-techniques
#10
Jinglong Niu, Yan Shi, Maolin Cai, Zhixin Cao, Dandan Wang, Zhaozhi Zhang, Xiaohua Douglas Zhang
Motivation: Sputum in the trachea is hard to expectorate and detect directly for the patients who are unconscious, especially those in Intensive Care Unit (ICU). Medical staff should always check the condition of sputum in the trachea. This is time-consuming and the necessary skills are difficult to acquire. Currently, there are few automatic approaches to serve as alternatives to this manual approach. Results: We develop an automatic approach to diagnose the condition of the sputum...
October 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29040395/human-genome-sequencing-at-the-population-scale-a-primer-on-high-throughput-dna-sequencing-and-analysis
#11
Rachel L Goldfeder, Dennis P Wall, Muin J Khoury, John P A Ioannidis, Euan A Ashley
Most human diseases have underlying genetic causes. To better understand the impact of genes on disease and its implications for medicine and public health, researchers have pursued methods for determining the sequences of individual genes, then all genes, and now complete human genomes. Massively parallel high-throughput sequencing technology, where DNA is sheared into smaller pieces, sequenced, and then computationally reordered and analyzed, enables fast and affordable sequencing of full human genomes. As the price of sequencing continues to decline, more and more individuals are having their genomes sequenced...
October 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29040344/dilemmas-for-guardians-of-advanced-dementia-patients-regarding-tube-feeding
#12
Efrat Gil, Maayan Agmon, Ayal Hirsch, Miriam Ziv, Anna Zisberg
Background: advanced dementia is an incurable illness, its last stage marked by inability to eat. Tube feeding was deemed a helpful solution at this stage, but in recent years its inefficiency has been proved, and it is no longer practiced in many countries around the world. In Israel, however, the procedure is still accepted. In the gastroenterology department at the Bnai Zion Medical Center, a serious interaction is ongoing with patients' legal guardians, where detailed information is given about the inefficiency of the tube procedure...
October 13, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29040242/epidemiology-and-predictors-of-orbital-fractures-in-children
#13
Andrew F Miller, Daniel M Elman, Paul L Aronson, Amir A Kimia, Mark I Neuman
OBJECTIVES: Data regarding clinical predictors of orbital fractures in children are limited. We sought to describe the epidemiology of pediatric orbital fractures and identify the signs and symptoms of orbital fractures in children. METHODS: We performed a retrospective cohort study of children younger than 22 years who underwent a facial or orbital computed tomography (CT) scan to evaluate for orbital fracture. We included patients presenting to an emergency department of a tertiary care children's hospital between January 2009 and May 2013...
October 16, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29039729/antimicrobial-activity-of-ceftolozane-tazobactam-tested-against-enterobacteriaceae-and-pseudomonas-aeruginosa-with-various-resistance-patterns-isolated-in-u-s-hospitals-2013-2016-as-part-of-the-surveillance-program-program-to-assess-ceftolozane-tazobactam-susceptibility
#14
Dee Shortridge, Michael A Pfaller, Mariana Castanheira, Robert K Flamm
This study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Enterobacteriaceae and Pseudomonas aeruginosa isolates from hospitalized patients in the United States. Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. A total of 18,960 organisms (15,223 Enterobacteriaceae and 3,737 P. aeruginosa) were consecutively collected from 32 medical centers located in all nine U.S. census divisions from 2013 to 2016...
October 17, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29039692/imaging-spectrum-of-immunomodulating-chemotherapeutic-and-radiation-therapy-related-intracranial-effects
#15
Christie Mary Lincoln, Peter Fata, Susan Sotardi, Michael Pohlen, Tomas Uribe, Jacqueline A Bello
OBJECTIVE: A wide range of treatment-related side effects result in specific neurologic symptoms and signs and neuroimaging features. Even to the most seasoned neuroradiologist, elucidating therapy-related side effects from other common mimics can be challenging. We provide a pictorial survey of some common and uncommon medication induced and therapy related neuroimaging manifestations, discuss pathophysiology and common pitfalls in imaging and diagnosis. METHODS/RESULTS: A case based review is utilized to depict scenarios on a routine basis in a general radiology or neuroradiology practice such as medication induced PRES to the more challenging cases of pseudoprogression and pseudoregression in temozolmide and bevacizumab therapy in gliobastoma treatment protocols...
October 17, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29039373/disepi-compact-visualization-as-a-tool-for-applied-epidemiological-research
#16
Arriel Benis, Moshe Hoshen
Outcomes research and evidence-based medical practice is being positively impacted by proliferation of healthcare databases. Modern epidemiologic studies require complex data comprehension. A new tool, DisEpi, facilitates visual exploration of epidemiological data supporting Public Health Knowledge Discovery. It provides domain-experts a compact visualization of information at the population level. In this study, DisEpi is applied to Attention-Deficit/Hyperactivity Disorder (ADHD) patients within Clalit Health Services, analyzing the socio-demographic and ADHD filled prescription data between 2006 and 2016 of 1,605,800 children aged 6 to 17 years...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29037998/identification-and-analysis-of-the-genetic-causes-in-nine-unrelated-probands-with-syndromic-craniosynostosis
#17
Yufei Xu, Shouqing Sun, Niu Li, Tingting Yu, Xiumin Wang, Jian Wang, Nan Bao
Syndromic craniosynostosis is a group of multiple conditions with high heterogeneity, and many rare syndromes still remain to be characterized. To identify and analyze causative genetic variants in nine unrelated probands mainly manifested as syndromic craniosynostosis, we reviewed the relevant medical information of the patients and performed the whole exome sequencing, further verified with Sanger sequencing and parental background. Bioinformatics analysis was used to evaluate the potential deleterious or benign effect of each genetic variant through evolutionary conservation alignment, multi-lines of computer predication and the allele frequency in population dataset (control and patient)...
October 13, 2017: Gene
https://www.readbyqxmd.com/read/29037573/pharmacists-scope-of-practice-supports-for-canadians-with-diabetes
#18
Kerry Mansell, Kirsten Edmunds, Lisa Guirguis
OBJECTIVES: The pharmacists' role in Canada has significantly advanced over the past decade, resulting in increasing access to primary care services. This study aimed to characterize pharmacists' expanded scope of practice as it relates to providing services to Canadians with diabetes. METHODS: This environmental scan characterized services that could be useful to Canadians with diabetes in each of the provinces (excluding the territories): immunizations, medication prescribing, ordering and interpreting laboratory tests, and medication reviews...
October 13, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29036756/acupuncture-or-acupressure-for-induction-of-labour
#19
REVIEW
Caroline A Smith, Mike Armour, Hannah G Dahlen
BACKGROUND: This is one of a series of reviews of methods of cervical ripening and labour induction. The use of complementary therapies is increasing. Women may look to complementary therapies during pregnancy and childbirth to be used alongside conventional medical practice. Acupuncture involves the insertion of very fine needles into specific points of the body. Acupressure is using the thumbs or fingers to apply pressure to specific points. The limited observational studies to date suggest acupuncture for induction of labour has no known adverse effects to the fetus, and may be effective...
October 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29036640/toxicokinetics-of-the-synthetic-cathinone-%C3%AE-pyrrolidinohexanophenone
#20
Yuji Fujita, Toshinori Mita, Kiyotaka Usui, Yoshito Kamijo, Satoshi Kikuchi, Makoto Onodera, Yasuhisa Fujino, Yoshihiro Inoue
Synthetic cathinones inhibit monoamine transporters, such as serotonin, norepinephrine, and dopamine transporters, and act on the central nervous system via increasing synaptic concentrations of monoamines. These compounds, which are highly addictive and potentially poisonous, are new psychoactive substances. In this study, we investigated the toxicokinetics of the synthetic cathinone, α-pyrrolidinohexanophenone (α-PHP), and assessed the relationship between the toxicokinetics and the long-term clinical symptoms induced by α-PHP in a male patient...
September 28, 2017: Journal of Analytical Toxicology
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